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Xianliang Wang, Jie Li, Pei Wang, Ke Yuan, Gang Yin, Bin Wan
PURPOSE: The purpose of this study was to demonstrate the dosimetric and clinical feasibility of image guided radiation therapy (IGRT) combined with high-dose-rate (HDR) intracavitary brachytherapy (ICBT) to improve dose distribution in cervical cancer treatment. MATERIAL AND METHODS: For 42 cervical cancer patients, magnetic resonance imaging (MRI) scans were acquired after completion of whole pelvic irradiation 45-46 Gy and 5 fractions of B + I (ICBT + IGRT) treatment were subsequently received...
April 2016: Journal of Contemporary Brachytherapy
Satoshi Nakamura, Naoya Murakami, Koji Inaba, Akihisa Wakita, Kazuma Kobayashi, Kana Takahashi, Hiroyuki Okamoto, Rei Umezawa, Madoka Morota, Minako Sumi, Hiroshi Igaki, Yoshinori Ito, Jun Itami
BACKGROUND: The study aimed to compare urinary symptoms in patients with clinically localized prostate cancer after a combination of either low-dose-rate or high-dose-rate interstitial brachytherapy along with intensity-modulated radiation therapy (LDR-ISBT + IMRT or HDR-ISBT + IMRT). METHODS: From June 2009 to April 2014, 16 and 22 patients were treated with LDR-ISBT + IMRT and HDR-ISBT + IMRT, respectively. No patient from these groups was excluded from this study...
2016: BMC Cancer
Ketevan Keshelashvili, Alix O'meara, Martin Stern, Zuzana Jirout, Vildana Pehlic, Andreas Holbro, Andreas Buser, Jörg Sigle, Laura Infanti
BACKGROUND: Safety of double-erythrocyte (2RBC) collection and reasons for ceasing 2RBC donation were retrospectively analysed in the blood donor population of Basel, Switzerland. METHODS: Donors with at least 1 2RBC apheresis were included in the study. Minimal requirements were Hb ≥140 g/L and body weight ≥70 kg; serum ferritin (SF) values were measured routinely, but were not part of the selection criteria. 2RBC collections were performed with ALYX devices at 6-month intervals...
September 2016: Blood Transfusion, Trasfusione del Sangue
Shumei Murakami, Rinus G Verdonschot, Naoya Kakimoto, Iori Sumida, Masateru Fujiwara, Kazuhiko Ogawa, Souhei Furukawa
PURPOSE: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. METHODS: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. RESULTS: With increasing distance to the source absorbed doses dropped considerably...
2016: PloS One
Naoya Murakami, Tomoyasu Kato, Yuichiro Miyamoto, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Keisuke Tsuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Kana Takahashi, Rei Umezawa, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Jun Itami
BACKGROUND: The aim of this study was to report the clinical results of salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) for patients with cervical cancer with pelvic recurrence after hysterectomy. PATIENTS AND METHODS: When there was no indication for total pelvic extenteration (TPE) and the tumor depth was more than 5 mm of invasion in the paracolpium, salvage HDR-ISBT was applied. RESULTS: A total of 26 patients were included in this study...
May 2016: Anticancer Research
G E Gondolesi, G Mazariegos, T E Starzl
At the 14th International Small Bowel Transplant Symposium, (ISBTS2015) held in Buenos Aires, a session to recognize the pioneers that have dedicated their lives to make our current field possible was organized. Dr Thomas Starzl received the first Living Legend Award. A video interview was obtained at his office, edited, and later presented during the scientific meeting. More than 600 people saw Dr Starzl's interview, which captivated the audience for 40 minutes, before smiles, tears and the final applause erupted at the conclusion...
March 2016: Transplantation Proceedings
Sylwia Kellas-Ślęczka, Brygida Białas, Marek Fijałkowski, Piotr Wojcieszek, Marta Szlag, Agnieszka Cholewka, Maciej Ślęczka, Zofia Kołosza
PURPOSE: The aim of the study was to report our experience with high-dose-rate interstitial brachytherapy (HDR-ISBT) in locally advanced and recurrent vulvar cancer. MATERIAL AND METHODS: Between 2004 and 2014, fourteen women with locally advanced or recurrent vulvar cancer were treated using HDR-ISBT in our Centre. High-dose-rate interstitial brachytherapy was performed as a separate treatment or in combination with external beam radiotherapy (EBRT) (given prior to brachytherapy)...
February 2016: Journal of Contemporary Brachytherapy
S Nance, E A Scharberg, N Thornton, V Yahalom, I Sareneva, C Lomas-Francis
International rare blood donor panels or registries are important in the consistent availability of rare blood for patients who need this scarce resource. In countries where it has been possible to commit resources to this effort and often where the need is great, donors have been entered into a registry. The ISBT leadership recognized the importance of this very challenging inventory management activity and created a Working Party to support it. Individual countries support the WHO International Rare Donor Panel by submitting their donors' phenotype or genotype information to be catalogued into the database...
April 2016: Vox Sanguinis
Mark J Amsbaugh, Neal Bhatt, Thomas Hunter, Jeremy Gaskins, Lynn Parker, Daniel Metzinger, Ashley Amsbaugh, Keith Sowards, Moataz N El-Ghamry
PURPOSE: To identify dosimetric predictors of outcome and toxicity in patients receiving CT-planned interstitial brachytherapy (ISBT) for gynecologic cancers. METHODS AND MATERIALS: Patients who received ISBT between 2009 and 2014 were reviewed. Demographic, disease specific, treatment, and toxicity data were collected. Logistic regression was used to model toxicity. A least absolute shrinkage and selection operator penalty was used to identify relevant predictors...
January 2016: Brachytherapy
Ken Yoshida, Hideya Yamazaki, Tadayuki Kotsuma, Tadashi Takenaka, Mari Mikami Ueda, Shunsuke Miyake, Yutaka Tsujimoto, Koji Masui, Yasuo Yoshioka, Iori Sumida, Yasuo Uesugi, Taiju Shimbo, Nobuhiko Yoshikawa, Hiroto Yoshioka, Eiichi Tanaka, Yoshifumi Narumi
PURPOSE: To choose the optimal brachytherapeutic modality for uterine cervical cancer, we performed simulation analysis. METHODS AND MATERIALS: For each high-risk clinical target volume (HR CTV), we compared four modalities [classical conventional intracavitary brachytherapy (ConvICBT), Image-guided ICBT (IGICBT), intracavitary/interstitial brachytherapy (ICISBT), and interstitial brachytherapy (ISBT) with perineal approach] using dose-volume histograms using eight sizes of HR CTV (2 × 2 × 2 cm to 7 × 4 × 4 cm) and organs at risk model...
January 2016: Brachytherapy
M Goldman, K Land, P Robillard, J Wiersum-Osselton
Standard definitions of donor reactions allow each blood establishment to monitor donor adverse events and compare with other organizations to develop best practices. The ISBT Haemovigilance Working Party leads a multi-organizational effort to update the 2008 ISBT standard for surveillance of complications related to blood donation. Revised definitions have been developed and endorsed by the ISBT, AABB, International Haemovigilance Network (IHN) and other international organizations.
February 2016: Vox Sanguinis
G Chen, X Q Wang, X Rong, P Wang, F J Xu, N Tang, Z X Qin, Y H Chen, B Shen
Utilizing the growth temperature controlled epitaxy, high quality GaN/In0.15Ga0.85N multiple quantum wells designed for intersubband transition (ISBT) as novel candidates in III-nitride infrared device applications have been experimentally realized for the first time. Photo-absorption originated from the ISBT has been successfully observed at infrared regime covering the 3-5 μm atmosphere window, where the central absorption wavelength is modulated by adjusting the quantum well width. With increasing the quantum well thickness, the ISBT center wave length blue shifts at thickness less than 2...
2015: Scientific Reports
Mark J Amsbaugh, Neal Bhatt, Thomas Hunter, Jeremy Gaskins, Lynn Parker, Daniel Metzinger, Ashley Amsbaugh, Keith Sowards, Moataz El-Ghamry
PURPOSE: To report outcomes and identify predictors of toxicity in patients undergoing reirradiation with interstitial brachytherapy (ISBT) for recurrent cancers of the female reproductive tract. METHODS AND MATERIALS: Twenty-one patients received ISBT performed using (192)Ir sources (10 low dose rate and 11 high dose rate) at our institution between 2009 and 2013. Demographic, disease specific, treatment, toxicity, and outcome data were collected. Kaplan-Meier and proportional hazard models were used to estimate survival and logistic regression to model toxicity...
September 2015: Brachytherapy
Julia S Westman, John Benktander, Jill R Storry, Thierry Peyrard, Annika K Hult, Åsa Hellberg, Susann Teneberg, Martin L Olsson
The x2 glycosphingolipid is expressed on erythrocytes from individuals of all common blood group phenotypes and elevated on cells of the rare P/P1/P(k)-negative p blood group phenotype. Globoside or P antigen is synthesized by UDP-N-acetylgalactosamine:globotriaosyl-ceramide 3-β-N-acetylgalactosaminyltransferase encoded by B3GALNT1. It is the most abundant non-acid glycosphingolipid on erythrocytes and displays the same terminal disaccharide, GalNAcβ3Gal, as x2. We encountered a patient with mutations in B3GALNT1 causing the rare P-deficient P1 (k) phenotype and whose pretransfusion plasma was unexpectedly incompatible with p erythrocytes...
July 24, 2015: Journal of Biological Chemistry
Yuki Otani, Takayuki Nose, Takushi Dokiya, Toshiaki Saeki, Yu Kumazaki, Shuuji Asahi, Iwao Tsukiyama, Ichirou Fukuda, Hiroshi Sekine, Naoto Shikama, Takao Takahashi, Ken Yoshida, Tadayuki Kotsuma, Norikazu Masuda, Eisaku Yoden, Kazutaka Nakashima, Taisei Matsumura, Shino Nakagawa, Seiji Tachiiri, Yoshio Moriguchi, Jun Itami, Masahiko Oguchi
BACKGROUND: In Japan, breast-conserving surgery with closed cavity has generally been performed for breast cancer patients, and accelerated partial breast irradiation (APBI) is considered difficult because Asian females generally have smaller breast sizes than Western females. Therefore, common identification of target and treatment plan method in APBI is required. A prospective multicenter study was conducted in Japan to determine institutional compliance with APBI using high-dose-rate interstitial brachytherapy (ISBT) designed for Japanese female patients...
2015: Radiation Oncology
Deepinder P Singh, Kevin C Bylund, Ahmad Matloubieh, Ali Mazloom, Alexander Gray, Ravinder Sidhu, Lucille Barrette, Yuhchyau Chen
PURPOSE: To evaluate recurrent vaginal cancer treated with vaginal brachytherapy (VBT) using graphic optimization in patients not amenable to surgery and interstitial brachytherapy (ISBT). MATERIAL AND METHODS: We retrospectively reviewed the records of 5 patients with recurrent cancer in the vagina that were deemed not to be good candidates for ISBT implant because of medical reasons. All patients received computed tomography/magnetic resonance imaging (CT/MRI) based evaluation in addition to a detailed clinical examination, and were noted to have recurrent nodules in the vagina with size ranging from 10-25 mm...
April 2015: Journal of Contemporary Brachytherapy
Carola Wieckhusen, Peter Bugert
The KEL (ISBT 006), JR (ISBT 032), and LAN (ISBT 033) blood group systems are defined by a complex genetics with a large number of exons, and numerous gene variants. In order to sequence the 53 coding exons and flanking intron regions of all three blood group genes we developed a next-generation-sequencing method using 454-sequencing™ on a Genome Sequencer (GS) Junior™ system. Multiplex analysis of eight individual DNA samples was achieved using molecular identifiers.
2015: Methods in Molecular Biology
Stephanie A Boccoz, Gaëlle Le Goff, Loïc J Blum, Christophe A Marquette
Thirty-five blood group systems, containing more than 300 antigens, are listed by the International Society of Blood Transfusion (ISBT). Most of these antigens result from a single-nucleotide polymorphism (SNP). Blood group typing is conventionally carried out by serology. However, this technique has certain limitations and cannot respond to the growing demand for blood products typed for a large number of antigens. Here we describe a blood group genotyping assay, from genomic DNA extraction from whole-blood samples to results...
2015: Methods in Molecular Biology
Thomas Braschler, Cora Alexandra Vökt, Hein Hustinx, Thierry Peyrard, Laura Infanti, Andreas Buser, Andreas Holbro
BACKGROUND: Holley (Hy) is a high-incidence antigen of the Dombrock blood group system (ISBT 014), present in almost 100% of most populations and more than 99% of Blacks. Since anti-Hy is an extremely rare antibody, data on its clinical relevance and in particular on a possible hemolytic disease of the fetus and newborn (HDFN) are scarce. CASE REPORT: The pregnant patient underwent two autologous whole blood collections at weeks 17 and 19 of gestation with cryopreservation...
March 2015: Transfusion Medicine and Hemotherapy
Ken Yoshida, Hideya Yamazaki, Tadayuki Kotsuma, Tadashi Takenaka, Koji Masui, Yasuo Yoshioka, Yasuo Uesugi, Taiju Shimbo, Nobuhiko Yoshikawa, Hiroto Yoshioka, Yoshifumi Narumi, Keiji Tatsumi, Eiichi Tanaka
PURPOSE: We analyzed clinical data to evaluate the effectiveness of image-guided high-dose-rate interstitial brachytherapy (HDR-ISBT) for pelvic recurrence of uterine cancer. METHODS AND MATERIALS: Between 2003 and 2011, 56 patients were treated with HDR-ISBT with or without external beam radiotherapy (EBRT). The median followup time was 33 months (range, 1-109 months). Pre-ISBT treatments included radical hysterectomy for 35 patients (Group A), radical hysterectomy with postoperative radiotherapy for 8 patients (Group B), and radical radiotherapy for 13 patients (Group C)...
July 2015: Brachytherapy
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