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https://www.readbyqxmd.com/read/29608322/a-review-of-in-vitro-methods-to-predict-the-clinical-significance-of-red-blood-cell-alloantibodies
#1
Sandra J Nance
This review was derived from a presentation made on September 2, 2016, for the first Academy Day presented by the Working Party on Immunohematology at the International Society of Blood Transfusion (ISBT) Congress in Dubai. The focus of this review is on the clinical significance of alloimmunization in transfusion-specifically, the parameters that contribute to a clinically significant alloantibody. The areas of focus were as follows: Introduction, Technical Aspects, and Indications and Limitations. Each section contains a brief review of selected literature and experiential knowledge...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29608320/a-brief-overview-of-clinical-significance-of-blood-group-antibodies
#2
Manish J Gandhi, D M Strong, Barbee I Whitaker, Evangelia Petrisli
This review was derived from a presentation made on September 2, 2016 for the first Academy Day presented by the Working Party on Immunohematology at the International Society of Blood Transfusion (ISBT) Congress in Dubai. The focus of this review is to provide a brief overview of the clinical significance of blood group antibodies. Blood group antibodies can be naturally occurring (e.g., anti-A and anti-B through exposure to naturally occurring red blood cell [RBC] antigen-like substances) or can occur via exposure to foreign (donor) RBC antigens through previous transfusions, transplants, or exposure to fetal RBCs during or after pregnancy...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29582438/a-pilot-serosurvey-of-babesia-microti-in-chinese-blood-donors
#3
E M Bloch, Y Yang, M He, L Tonnetti, Y Liu, J Wang, Y Guo, H Li, D A Leiby, H Shan
BACKGROUND AND OBJECTIVES: Babesia spp. are tick-borne, intraerythrocytic protozoan parasites, several of which are transfusion-transmissible. Transfusion-transmitted babesiosis poses serious risk to a diverse patient population, including neonates, patients aged >50 years, the asplenic and the immunocompromised that are over-represented among transfusion recipients. Despite reports of B. microti and B. venatorum in People's Republic of China (PRC), no surveillance of blood donors for Babesia has previously been undertaken...
March 26, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29444582/short-communication-dolutegravir-based-regimens-are-active-in-integrase-strand-transfer-inhibitor-naive-patients-with-nucleoside-reverse-transcriptase-inhibitor-resistance
#4
James Demarest, Mark Underwood, Marty St Clair, David Dorey, Dannae Brown, Andrew Zolopa
In the SAILING study, dolutegravir demonstrated superior virologic efficacy compared with raltegravir in treatment-experienced, integrase strand transfer inhibitor (INSTI)-naive patients with HIV-1 who harbored resistance to ≥2 antiretroviral drug classes. Significantly fewer dolutegravir-treated patients demonstrated virologic failure with treatment-emergent resistance than raltegravir-treated patients through 48 weeks. Investigator-selected background therapy (ISBT) included at least one fully active agent, selected on the basis of resistance analysis...
April 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29344017/global-registration-identifier-for-donors-grid-of-hematopoietic-stem-cells-road-to-automation-and-safety
#5
REVIEW
Joachim Klaus Neller, Paul Ashford, Caroline van Veen, Andreas Humpe
Once a cohort exceeds a certain size, it becomes mandatory to assign an identifier (ID) for each individual to ensure a secure, reliable, and unambiguous assignment. In the field of hematopoietic stem cell transplantation, with a still growing number of voluntary unrelated donors, it was recognized that a system needs to be developed to uniquely identify potential donors on a global scale to facilitate communication and to prevent errors in identification of donors. Efforts in this respect resulted in establishment of the GRID, with a defined structure and allocated rules...
November 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29344013/isbt-128-standard-for-coding-medical-products-of-human-origin
#6
REVIEW
Paul Ashford, Matthew Delgado
Background: ISBT 128 is an international standard for the terminology, coding, labeling, and identification of medical products of human origin (MPHO). Full implementation of ISBT 128 improves traceability, transparency, vigilance and surveillance, and interoperability. Methods: ICCBBA maintains the ISBT 128 standard through the activities of a network of expert volunteers, including representatives from professional scientific societies, governments and users, to standardize and maintain MPHO identification...
November 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29275869/image-guided-interstitial-high-dose-rate-brachytherapy-for-locally-recurrent-uterine-cervical-cancer-a-single-institution-study
#7
Rei Umezawa, Naoya Murakami, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Keisuke Tsuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Koji Masui, Ken Yoshida, Keiichi Jingu, Nikolaos Tselis, Jun Itami
PURPOSE: The aim of this study was to investigate the efficacy and safety of image-guided high-dose-rate (HDR) interstitial brachytherapy (ISBT) for reirradiation of locally recurrent uterine cervical cancer. METHODS AND MATERIALS: Between 2008 and 2015, patients receiving reirradiation using HDR-ISBT for local gross recurrence of uterine cervical cancer after definitive or postoperative radiotherapy were analyzed retrospectively. The prescription doses per fraction ranged 2...
March 2018: Brachytherapy
https://www.readbyqxmd.com/read/29193200/rapid-identification-of-microorganisms-from-platelet-concentrates-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-after-short-term-incubation-on-liquid-medium
#8
Yasmine Chetouane, Gregory Dubourg, Pierre Gallian, Christophe Flaudrops, Jacques Chiaroni, Eric Chabrière, Didier Raoult, Laurence Camoin-Jau
BACKGROUND: Platelets (PLTs) are especially affected by the risk of bacterial contamination. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) is an accurate method for the routine identification of bacterial isolates in microbiology laboratories. We directly applied the MALDI-TOF method to bacterial detection in PLTs. In this study, we evaluated the sensitivity, specificity, and speed of a direct MALDI-TOF approach compared to the conventional method BACTEC. STUDY DESIGN AND METHODS: Eight bacteria associated with PLT contamination, cited by the ISBT on transfusion-transmitted infectious diseases, were spiked into PLTs for a final concentration of approximately 100 CFU/bag (n = 5 for each strain)...
March 2018: Transfusion
https://www.readbyqxmd.com/read/29187469/brachytherapy-for-buccal-cancer-from-conventional-low-dose-rate-ldr-or-mold-technique-to-high-dose-rate-interstitial-brachytherapy-hdr-isbt
#9
Tadayuki Kotsuma, Hideya Yamazaki, Koji Masui, Ken Yoshida, Kimishige Shimizutani, Hironori Akiyama, Shumei Murakami, Fumiaki Isohashi, Yasuo Yoshioka, Kazuhiko Ogawa, Eiichi Tanaka
BACKGROUND/AIM: To examine the effectiveness of newly-installed high-dose-rate interstitial brachytherapy (HDR-ISBT) for buccal cancer. PATIENTS AND METHODS: We retrospectively reviewed 36 patients (25 men and 11 women) with buccal cancer treated with curative brachytherapy with or without external radiotherapy with a median follow-up of 99 months. A total of 15 HDR-ISBT (median 48 Gy/ 8 fractions, range=24-60 Gy) patients were compared to conventional 15 cases LDR-ISBT (70 Gy, range=42...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29136288/28th-regional-congress-of-the-isbt-guangzhou-china-november-25-28-2017
#10
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29107387/dynamics-of-the-vaginal-wall-dose-in-hdr-interstitial-brachytherapy-for-gynecological-cancer-systematic-analysis-of-phantom-vs-patient-case
#11
Robert Y Kim, Andrew M McDonald, Omer Lee Burnett, Sui Shen
This study aimed to investigate the dynamics of the vaginal wall dose for interstitial brachytherapy (ISBT). A patient undergoing ISBT was selected as the patient case. The phantom case was generated to simulate the patient case in all regards with the exception of parallel needle positions. The vaginal wall was contoured as a 0.5-cm expansion around the vaginal surface of the obturator. The prescribed ISBT dose was 20 Gy in 4 fractions. Six treatment plans were generated by modifying relative dwell times and needle positions (DTNP)...
October 26, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28970678/inra-a-new-high-frequency-antigen-in-the-indian-in023-blood-group-system
#12
Sanmukh R Joshi, Ankita Sheladiya, Kinjal V Mendapara-Dobariya
BACKGROUND: The INDIAN blood group system comprises 4 antigens sensitive to enzymes and 2-aminoethyl isothiouronium bromide (AET). AIM: The patient's antibody was investigated for its specificity to the high-frequency antigens (HFA) of this system. MATERIAL AND METHODS: Low ionic strength solution (LISS)-tube/LISS-indirect antiglobulin test (IAT) methods were used. The patient's red blood cells (RBCs) were tested with antisera to HFA. Her antibody was tested with RBCs lacking the HFA...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28960367/enlargement-of-the-who-international-repository-for-platelet-transfusion-relevant-bacteria-reference-strains
#13
E Spindler-Raffel, R J Benjamin, C P McDonald, S Ramirez-Arcos, K Aplin, I Bekeredjian-Ding, D de Korte, C Gabriel, B Gathof, K-M Hanschmann, K Hourfar, C Ingram, M R Jacobs, S D Keil, Y Kou, B Lambrecht, J Marcelis, Z Mukhtar, H Nagumo, T Niekerk, J Rojo, S Marschner, M Satake, A Seltsam, E Seifried, S Sharafat, M Störmer, S Süßner, S J Wagner, R Yomtovian
BACKGROUND AND OBJECTIVES: Interventions to prevent and detect bacterial contamination of platelet concentrates (PCs) have reduced, but not eliminated the sepsis risk. Standardized bacterial strains are needed to validate detection and pathogen reduction technologies in PCs. Following the establishment of the First International Reference Repository of Platelet Transfusion-Relevant Bacterial Reference Strains (the 'repository'), the World Health Organization (WHO) Expert Committee on Biological Standardisation (ECBS) endorsed further repository expansion...
November 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28725243/outcomes-of-salvage-high-dose-rate-brachytherapy-with-or-without-external-beam-radiotherapy-for-isolated-vaginal-recurrence-of-endometrial-cancer
#14
Shuhei Sekii, Naoya Murakami, Tomoyasu Kato, Ken Harada, Mayuka Kitaguchi, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Yoshinori Ito, Ryohei Sasaki, Jun Itami
PURPOSE: This study was designed to retrospectively analyze outcomes of high-dose-rate (HDR) brachytherapy, with or without external beam radiotherapy (EBRT), in patients with vaginal recurrence of endometrial carcinoma, and to identify factors prognostic of patient outcomes. MATERIAL AND METHODS: The medical records of all patients who underwent HDR brachytherapy for initial recurrence in the vagina of endometrial cancer after definitive surgery between 1992 and 2014 were retrospectively reviewed...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28705549/-voluntary-and-non-remunerated-blood-donation-current-situation-and-perspectives
#15
M Monsellier
The voluntary and unpaid blood donation is recommended by all international authorities (WHO, Council of Europe, ISBT, EBA), because it represents the best way of aiming towards self-sufficiency in blood products of all kinds, while preserving an optimal level of quality and safety for recipients as for donors. Still infrequent in many developing countries it tends to develop. However, the objective assigned by the WHO to reach 100% of unpaid and voluntary blood donations in 2020 appears ambitious, in particular for the collection of plasma intended to the splitting industry...
July 10, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28669524/from-genetic-variability-to-phenotypic-expression-of-blood-group-systems
#16
L Raud, C Férec, Y Fichou
More than 300 red blood cell (RBC) antigens belonging to 36 blood group systems have been officially reported in humans by the International Society of Blood Transfusion (ISBT). Phenotypic variability is directly linked to the expression of the 41 blood group genes. The Rh blood group system, which is composed of 54 antigens, is the most complex and polymorphic system. Many rare genetic variants within the RH (RHD and RHCE) genes, involving various mutational mechanisms (single-nucleotide substitutions, short insertions/deletions, rearrangements, large deletions), have been reported in the literature and reference databases...
November 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28657765/the-fors-awakens-review-of-a-blood-group-system-reborn
#17
Annika K Hult, Martin L Olsson
The presence of the FORS1 antigen on red blood cells was discovered relatively recently, and in 2012, the International Society of Blood Transfusion (ISBT) acknowledged FORS as blood group system number 031. This rare antigen is carried by a glycosphingolipid and formed by elongation of the P antigen. Most people have naturally occurring anti-FORS1 in their plasma. The clinical significance of these antibodies is unknown in the transfusion setting, but they can hemolyze FORS1+ erythrocytes in the presence of complement in vitro...
June 2017: Immunohematology
https://www.readbyqxmd.com/read/28639703/an-assessment-of-differences-in-costs-and-health-benefits-of-serology-and-nat-screening-of-donations-for-blood-transfusion-in-different-western-countries
#18
M P Janssen, M van Hulst, B Custer
BACKGROUND AND OBJECTIVES: The cost-utility of safety interventions is becoming increasingly important as a driver of implementation decisions. The aim of this study was to compare the cost-utility of different blood screening strategies in various settings, and to analyse the extent and cause of differences in health economic results. MATERIALS AND METHODS: For eight Western countries (Australia, Canada, Denmark, Finland, France, The Netherlands, UK and the United States of America), data were collected on donor and recipient populations, blood products, screening tests, and on patient treatment practices and costs...
August 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28608429/27th-regional-congress-of-the-isbt-copenhagen-denmark-june-17-21-2017
#19
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28578919/opioid-consumption-and-pain-in-gynecological-cancer-patients-treated-with-interstitial-brachytherapy
#20
Lucas C Mendez, Stephen Choi, Laura D'Alimonte, Elizabeth Barnes, Lisa Barbera, Eric Leung
PURPOSE: Interstitial brachytherapy (ISBT) has advantages over the intracavitary techniques in the treatment of gynecological malignancies. The insertion of catheters into tumor enables higher dose conformality and normal tissue sparing. However ISBT can be associated with pain due its invasiveness. The goal of this study is to assess pain and opioid consumption of patients implanted with a perineal ISBT applicator. METHODS AND MATERIALS: Forty-eight patients were treated with ISBT from September 2014 to April 2016...
July 2017: Brachytherapy
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