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https://www.readbyqxmd.com/read/29045142/measuring-intracellular-secondary-structure-of-a-cell-penetrating-peptide-in-situ
#1
Frederik Fleissner, Sabine Pütz, Mischa Schwendy, Mischa Bonn, Sapun H Parekh
Cell penetrating peptides (CPPs) are short peptide sequences that can translocate across cellular plasma membranes and are thus potential delivery vectors for diagnostic and therapeutic applications. Many CPPs exhibit some sort structural polymorphism, where the secondary structure of the peptide is altered strongly by its local environment, which is believed to facilitate membrane translocation. However, the fate and structure of CPPs within cells is much less known due to measurement difficulty. Here we employ isotopic labelling combined with hyperspectral, quantitative coherent-Raman vibrational microscopy to localize a model CPP - deuterated Penetratin (d-Pen) - and determine its secondary structure in different cellular compartments...
October 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29043054/woody-structure-facilitates-invasion-of-woody-plants-by-providing-perches-for-birds
#2
Chelse M Prather, Andrew Huynh, Steven C Pennings
Woody encroachment threatens prairie ecosystems globally, and thus understanding the mechanisms that facilitate woody encroachment is of critical importance. Coastal tallgrass prairies along the Gulf Coast of the US are currently threatened by the spread of several species of woody plants. We studied a coastal tallgrass prairie in Texas, USA, to determine if existing woody structure increased the supply of seeds from woody plants via dispersal by birds. Specifically, we determined if (i) more seedlings of an invasive tree (Tridacia sebifera) are present surrounding a native woody plant (Myrica cerifera); (ii) wooden perches increase the quantity of seeds dispersed to a grassland; and (iii) perches alter the composition of the seed rain seasonally in prairie habitats with differing amounts of native and invasive woody vegetation, both underneath and away from artificial wooden perches...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29040721/ratio-of-endogenous-secretory-receptor-for-advanced-glycation-end-products-to-pentosidine-predicts-fractures-in-men
#3
Junko Tamaki, Katsuyasu Kouda, Yuki Fujita, Masayuki Iki, Akiko Yura, Masakazu Miura, Yuho Sato, Nozomi Okamoto, Norio Kurumatani
Context: Although the endogenous secretory receptor for advanced glycation end products (esRAGE) has been associated with reduced activity of pentosidine (PEN), the association between PEN, esRAGE, and fracture is poorly understood. Objectives: To evaluate the ability of serum PEN and esRAGE levels to predict fragility fractures. Methods: A cohort of 1,285 Japanese men aged ≥65 years old participated in a 2007-2008 FORMEN Study baseline survey, as part of the Fujiwara-kyo prospective cohort study...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29039378/dna-encoding-training-using-3d-gesture-interaction
#4
Stelian Nicola, Flavia-Laura Handrea, Mihaela Crişan-Vida, Lăcrămioara Stoicu-Tivadar
The work described in this paper summarizes the development process and presents the results of a human genetics training application, studying the 20 amino acids formed by the combination of the 3 nucleotides of DNA targeting mainly medical and bioinformatics students. Currently, the domain applications using recognized human gestures of the Leap Motion sensor are used in molecules controlling and learning from Mendeleev table or in visualizing the animated reactions of specific molecules with water. The novelty in the current application consists in using the Leap Motion sensor creating new gestures for the application control and creating a tag based algorithm corresponding to each amino acid, depending on the position in the 3D virtual space of the 4 nucleotides of DNA and their type...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29038747/light-induced-intraspecific-variability-in-response-to-thermal-stress-in-the-hard-coral-stylophora-pistillata
#5
Arjen Tilstra, Tim Wijgerde, Francisco Dini-Andreote, Britas Klemens Eriksson, Joana Falcão Salles, Ido Pen, Ronald Osinga, Christian Wild
Recent research suggests that prior exposure of several months to elevated irradiance induces enhanced thermal tolerance in scleractinian corals. While this tolerance has been reported at the species level, individual coral colonies may react differently due to individual variability in thermal tolerance. As thermal anomalies are predicted to become common in the upcoming future, intraspecific variation may be key to the survival of coral populations. In order to study light-history based thermal stress responses on individual colonies, we developed a preliminary microcosm experiment where three randomly chosen, aquacultured colonies of the model coral Stylophora pistillata were exposed to two irradiance treatments (200 and 400 μmol photons m(-2) s(-1)) for 31 days, followed by artificially induced heat stress (∼33...
2017: PeerJ
https://www.readbyqxmd.com/read/29036819/age-and-graphomotor-decision-making-assessed-with-the-digital-clock-drawing-test-the-framingham-heart-study
#6
Ryan J Piers, Kathryn N Devlin, Boting Ning, Yulin Liu, Ben Wasserman, Joseph M Massaro, Melissa Lamar, Catherine C Price, Rod Swenson, Randall Davis, Dana L Penney, Rhoda Au, David J Libon
BACKGROUND: Digital Clock Drawing Test (dCDT) technology enables the examination of detailed neurocognitive behavior as behavior unfolds in in real time; a capability that cannot be obtained using a traditional pen and paper testing format. OBJECTIVE: Parameters obtained from the dCDT were used to investigate neurocognitive constructs related to higher-order neurocognitive decision-making and information processing speed. The current research sought to determine the effect of age as related to combined motor and non-motor components of drawing, and higher-order, decision-making latencies...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29035516/potential-metabolic-activation-of-representative-alkylated-polycyclic-aromatic-hydrocarbons-1-methylphenanthrene-and-9-ethylphenanthrene-associated-with-the-deepwater-horizon-oil-spill-in-human-hepatoma-hepg2-cells
#7
Meng Huang, Clementina A Mesaros, Linda C Hackfield, Richard P Hodge, Ian A Blair, Trevor M Penning
Exposure to petrogenic polycyclic aromatic hydrocarbons (PPAHs) is the major human health hazard associated with the Deepwater Horizon oil spill. Alkylated phenanthrenes are the most abundant PPAHs present in the crude oil and could contaminate the food chain. We describe the metabolism of a C1-phenanthrene regioisomer 1-methylphenanthrene (1-MP) and a C2-phenanthrene regioisomer 9-ethylphenanthrene (9-EP) in human HepG2 cells. The structures of the metabolites were identified by HPLC-UV-fluorescence detection and LC-MS/MS...
October 16, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29034154/intraocular-pressure-monitoring-by-rebound-tonometry-in-children-with-myopia
#8
Jenchieh Weng, I-Lun Tsai, Li-Lin Kuo, Ching-Yao Tsai, Lin-Chung Woung, Ya-Chuan Hsiao
BACKGROUND/PURPOSE: Topical atropine treatment is generally accepted to retard the progression of myopia, but it is associated with side effects such as photophobia and elevation of intraocular pressure (IOP). IOP measurements in children are challenging. The traditional applanation tonometry by direct contact with the cornea will require patient's cooperation. The rebound tonometer, using a dynamic electromechanical method for measuring IOP, shows good correlation with traditional tonometry...
July 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29034057/design-and-fabrication-of-a-low-cost-three-dimensional-bioprinter
#9
Colton McElheny, Daniel Hayes, Ram Devireddy
Three-dimensional (3D) bioprinting offers innovative research vectors for tissue engineering. However, commercially available bioprinting platforms can be cost prohibitive to small research facilities, especially in an academic setting. The goal is to design and fabricate a low-cost printing platform able to deliver cell-laden fluids with spatial accuracy along the X, Y, and Z axes of 0.1 mm. The bioprinter consists of three subassemblies: a base unit, a gantry, and a shuttle component. The platform utilizes four stepper motors to position along three axes and a fifth stepper motor actuating a pump...
December 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/29033507/syntax-score-of-infarct-related-artery-other-than-the-number-of-coronary-balloon-inflations-and-deflations-as-an-independent-predictor-of-contrast-induced-acute-kidney-injury-in-patients-with-st-segment-elevation-myocardial-infarction
#10
Cheng-Wei Liu, Pen-Chih Liao, Kuo-Chin Chen, Jung-Cheng Hsu, Chung-Ming Tu, Yen-Wen Wu, Ai-Hsien Li, Shin-Rong Ke, Jiunn-Lee Lin
BACKGROUND: Although remote ischemic post-conditioning (RIPC) has been shown to prevent contrast-induced acute kidney injury (CIAKI) in patients with acute coronary syndrome, its efficacy in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We examined the relationship among balloon inflations and deflations (BID) times, SYNTAX score of infarction-related artery (SI), periprocedural complications, and CIAKI in STEMI patients undergoing primary percutaneous coronary intervention (pPCI)...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29032411/hiv-prevalence-and-risk-behaviors-in-male-to-female-mtf-transgender-persons-in-tijuana-mexico
#11
Kristian Jesús Salas-Espinoza, Rufino Menchaca-Diaz, Thomas L Patterson, Lianne A Urada, Davey Smith, Steffanie A Strathdee, Eileen V Pitpitan
Compared to HIV research on men who have sex with men, less is known about the risks and vulnerabilities for HIV among Male to Female (MTF) transgender persons, particularly in different geographic regions like Mexico. In Tijuana, Mexico, a border city experiencing a dynamic HIV epidemic, no precedent data exists on the MTF transgender population. Our aims were to estimate HIV prevalence and examine the behaviors and characteristics of the population. We conducted a cross-sectional study of 100 MTF transgender persons recruited through time location sampling in 2012...
October 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29032125/rifm-fragrance-ingredient-safety-assessment-tetrahydro-4-methyl-2-2-methylpropen-1-yl-pyran-cas-registry-number-16409-43-1
#12
A M Api, D Belsito, S Bhatia, D Botelho, D Browne, M Bruze, A Burton, J Buschmann, P Calow, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, K Joshi, L Kromidas, S La Cava, J F Lalko, A Lapczynski, D C Liebler, Y Miyachi, D O'brien, R Parakhia, A Patel, T M Penning, V T Politano, G Ritacco, J Romine, D Salvito, T W Schultz, J Shen, I G Sipes, Y Thakkar, Y Tokura, S Tsang, J Wahler, B Wall, D K Wilcox
No abstract text is available yet for this article.
October 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29032124/rifm-fragrance-ingredient-safety-assessment-2-2-5-trimethyl-5-pentylcyclopentanone-cas-registry-number-65443-14-3
#13
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29032123/rifm-fragrance-ingredient-safety-assessment-3-hexen-1-ol-isomer-unspecified-cas-registry-number-544-12-7
#14
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29032122/rifm-fragrance-ingredient-safety-assessment-cis-3-octen-1-ol-cas-registry-number-20125-84-2
#15
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29031740/eyetracking-metrics-reveal-impaired-spatial-anticipation-in-behavioural-variant-frontotemporal-dementia
#16
Silvia Primativo, Camilla Clark, Keir Xx Yong, Nicholas C Firth, Jennifer Nicholas, Daniel Alexander, Jason D Warren, Jonathan D Rohrer, Sebastian J Crutch
Eyetracking technology has had limited application in the dementia field to date, with most studies attempting to discriminate syndrome subgroups on the basis of basic oculomotor functions rather than higher-order cognitive abilities. Eyetracking-based tasks may also offer opportunities to reduce or ameliorate problems associated with standard paper-and-pencil cognitive tests such as the complexity and linguistic demands of verbal test instructions, and the problems of tiredness and attention associated with lengthy tasks that generate few data points at a slow rate...
October 11, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29030261/rifm-fragrance-ingredient-safety-assessment-%C3%AE-isobutylphenethyl-alcohol-cas-registry-number-7779-78-4
#17
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29030259/rifm-fragrance-ingredient-safety-assessment-dihydro-%C3%AE-ionol-cas-registry-number-3293-47-8
#18
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29030258/rifm-fragrance-ingredient-safety-assessment-menthyl-acetate-isomer-unspecified-cas-registry-number-16409-45-3
#19
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29030257/rifm-fragrance-ingredient-safety-assessment-2-pentylcyclopentan-1-one-cas-registry-number-4819-67-4
#20
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 10, 2017: Food and Chemical Toxicology
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