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https://www.readbyqxmd.com/read/29244611/learning-new-letter-like-writing-patterns-explicitly-and-implicitly-in-children-and-adults
#1
M Jongbloed-Pereboom, A Overvelde, M W G Nijhuis-van der Sanden, B Steenbergen
A handwriting task was used to test the assumption that explicit learning is dependent on age and working memory, while implicit learning is not. The effect of age was examined by testing both, typically developing children (5-12 years old, n = 81) and adults (n = 27) in a counterbalanced within-subjects design. Participants were asked to repeatedly write letter-like patterns on a digitizer with a non-inking pen. Reproduction of the pattern was better after explicit learning compared to implicit learning. Age had positive effects on both explicit and implicit learning; working memory did not affect learning in either conditions...
December 15, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29240857/the-latest-drugs-and-small-molecule-inhibitors-for-skin-and-hair
#2
Varun Kalhun, Neil Sadick
<p>Biologic drugs, a novel class of agents engineered to target specifc mediators of infammation, and small-molecule inhibitors that pen-etrate the cell membrane to interact with targets inside a cell represent the cutting-edge of pharmacological biomedical therapeutics. Clinical studies have already demonstrated the effectiveness of this new generation of drugs in treating a variety of medical illnesses and conditions that were refractory to traditional treatments. This review aims to describe the latest available or currently in-develop-ment drugs, biologic agents, and small molecule inhibitors for treatment of psoriasis, rosacea, alopecia areata, and atopic dermatitis...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240589/infrared-skin-thermometry-validating-and-comparing-techniques-to-detect-periwound-skin-infection
#3
Asfandyar Mufti, Ranjani Somayaji, Patricia Coutts, R Gary Sibbald
OBJECTIVE: Diagnosis of wound infection can be challenging because it relies on a combination of clinical signs and symptoms that are often nonspecific. Increased periwound cutaneous temperature is a classic sign of deep and surrounding wound infection, and its quantitative measurement is one of the most reliable and valid clinical signs of deep and surrounding skin infection at the bedside. Skin surface temperature differences may be detected using commercially available noncontact infrared thermometers...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29238936/perceived-social-support-mediates-the-longitudinal-relations-between-ambivalence-over-emotional-expression-and-quality-of-life-among-chinese-american-breast-cancer-survivors
#4
William Tsai, Qian Lu
PURPOSE: The present study examined perceived social support as a mediator of the longitudinal link between ambivalence over emotional expression (AEE) and quality of life among a sample of Chinese breast cancer survivors. METHODS: Ninety-six Chinese breast cancer survivors recruited from Southern California completed four surveys in total: (1) a baseline survey (T1), 1-month follow-up (T2), 3-month follow-up (T3), and 6-month follow-up (T4). Participants filled out a paper-pen questionnaire containing the Ambivalence over Emotional Expression Questionnaire (AEQ), the Functional Assessment of Cancer Therapy-General (FACT-G), and the Medical Outcomes Study Social Support Scale (MOS-SSS)...
December 13, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29235697/remote-sampling-mass-spectrometry-for-dry-samples-sheath-flow-probe-electrospray-ionization-pesi-using-a-gel-loading-tip-inserted-with-an-acupuncture-needle
#5
Dilshadbek T Usmanov, Khatam B Ashurov, Satoshi Ninomiya, Kenzo Hiraoka, Hiroshi Wada, Hiroshi Nakano, Masaya Matsumura, Sachiyo Sanada-Morimura, Hiroshi Nonami
RATIONALE: Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath-flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed. METHODS: An acupuncture needle (0.12 mm outer diameter, 700 nm tip diameter) was inserted into a gel-loading tip with a 0.1 mm protrusion out of the tip. Analytes were extracted by filling the latter tip with solvent and softly touching the sample surface for a short time (<1 s)...
December 13, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29235214/the-effect-of-administration-of-copper-nanoparticles-to-chickens-in-their-drinking-water-on-the-immune-and-antioxidant-status-of-the-blood
#6
Katarzyna Ognik, Iwona Sembratowicz, Ewelina Cholewińska, Jan Jankowski, Krzysztof Kozłowski, Jerzy Juśkiewicz, Zenon Zduńczyk
The aim of this experiment was to determine what dosage of copper (Cu) nanoparticles, added to a standard dietary supplementation with copper sulfate, would improve antioxidant and immune defense in chickens. The experiment was conducted with 126 broiler chickens assigned to seven treatments with three pens per treatment and six broiler chickens per pen. The basal-diet treatment did not receive Cu nanoparticles (nano-Cu) and as shown by analyses it was Cu-deficient (-29% vs. National Research Council (NRC) recommendations; 5...
December 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29226723/pen-devices-for-self-injection-contrasting-measured-injection-force-with-users-perceived-ease-of-injection
#7
Andreas E Schneider, Jakob Lange
OBJECTIVES: Past research has emphasized injection force as a clinically highly relevant technical attribute of pen devices. However, little work has been conducted to relate these results to in-use studies. This article explores whether and how differences in pen injection force profiles influence users' self-reported perceived ease of injection and preferences. METHODS: Three different pen systems were subjected to measurements of injection force using an automated mechanical set-up followed by a simulated use study where users assessed perceived ease of injection...
December 9, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29225081/enteral-nutrition-and-quality-of-life-in-patients-undergoing-chemoradiotherapy-for-esophageal-carcinoma-a-comparison-of-nasogastric-tube-esophageal-stent-and-ostomy-tube-feeding
#8
Fang-Jung Yu, Hsiang-Yao Shih, Chien-Yi Wu, Yun-Shiuan Chuan, Jui-Ying Lee, Hsien-Pin Li, Pen-Tzu Fang, Dong-Lin Tsai, Shah-Hwa Chou, I-Chen Wu
BACKGROUND AND AIMS: This study prospectively recruited esophageal squamous-cell carcinoma patients who received esophageal stent, nasogastric tube (NG) or jejunostomy/gastrostomy feeding to compare the changes in nutritional status and quality of life during chemoradiation therapy (CRT). METHODS: In total, 81 patients were analyzed (stent 7, surgical ostomy 26, NG 19, oral intake 29). NG was inserted when despite medication dysphagia or pain worsened with oral feeding during CRT...
December 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29224869/effects-of-straw-processing-and-pen-overstocking-on-the-growth-performance-and-sorting-characteristics-of-diets-offered-to-replacement-holstein-dairy-heifers
#9
W K Coblentz, M S Akins, N M Esser, R K Ogden, S L Gelsinger
Our objectives were to evaluate the effects of pen-stocking density and straw processing on the growth performance, feed-bunk sorting behaviors, and hygiene of Holstein dairy heifers. Two corn silage-alfalfa haylage diets diluted with wheat straw were offered; diet composition was identical, except that one diet contained short (well-processed) straw (SS; 46.0% neutral detergent fiber, 12.9% crude protein, 60.7% total digestible nutrients, TDN), and the other long (poorly processed) straw (LS; 46.5% neutral detergent fiber, 12...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224863/quantifying-fecal-shedding-of-mycobacterium-avium-ssp-paratuberculosis-from-calves-after-experimental-infection-and-exposure
#10
Caroline S Corbett, Herman W Barkema, Jeroen De Buck
Johne's disease, a chronic enteritis caused by Mycobacterium avium ssp. paratuberculosis (MAP), causes large economic losses to the dairy industry worldwide. Fecal shedding of MAP contaminates the environment, feed, and water and contributes to new infections on farm, yet there is limited knowledge regarding mechanisms of shedding, extent of intermittent shedding, and numbers of MAP bacteria shed. The objectives were to (1) compare (in an experimental setting) the frequency at which intermittent shedding occurred and the quantity of MAP shed among pen mates that were inoculated or contact-exposed (CE); and (2) determine whether an association existed between inoculation dose and quantity of MAP shed...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29224139/antibody-based-detection-of-global-nuclear-dna-methylation-in-cells-tissue-sections-and-mammalian-embryos
#11
Nathalie Beaujean, Juliette Salvaing, Nur Annies Abd Hadi, Sari Pennings
Immunostaining is widely used in cell biology for the in situ detection of proteins in fixed cells. The method is based on the specificity of antibodies for recognizing and binding to a selected target, combined with immunolabeling techniques for microscopic imaging. Antibodies with high specificities for modified nucleotides have also been widely developed, and among those, antibodies that recognize modified cytosine: 5-methylcytosine (5mC), and more recently, its derivates 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222503/co2-mineralization-and-utilization-using-steel-slag-for-establishing-a-waste-to-resource-supply-chain
#12
Shu-Yuan Pan, Tai-Chun Chung, Chang-Ching Ho, Chin-Jen Hou, Yi-Hung Chen, Pen-Chi Chiang
Both steelmaking via an electric arc furnace and manufacturing of portland cement are energy-intensive and resource-exploiting processes, with great amounts of carbon dioxide (CO2) emission and alkaline solid waste generation. In fact, most CO2 capture and storage technologies are currently too expensive to be widely applied in industries. Moreover, proper stabilization prior to utilization of electric arc furnace slag are still challenging due to its high alkalinity, heavy metal leaching potentials and volume instability...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222410/tuning-the-interactions-between-chiral-plasmonic-films-and-living%C3%A2-cells
#13
Xueli Zhao, Liguang Xu, Maozhong Sun, Wei Ma, Xiaoling Wu, Chuanlai Xu, Hua Kuang
Designing chiral materials to manipulate the biological activities of cells has been an important area not only in chemistry and material science, but also in cell biology and biomedicine. Here, we introduce monolayer plasmonic chiral Au nanoparticle (NP) films modified with L- or D-penicillamine (Pen) to be developed for cell growth, differentiation, and retrieval. The monolayer films display high chiroptical activity, with circular dichroism values of 3.5 mdeg at 550 nm and 26.8 mdeg at 775 nm. The L-Pen-NP films accelerate cell proliferation, whereas the D -Pen-NP films have the opposite effect...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222362/randomized-controlled-evaluation-of-an-insulin-pen-storage-policy
#14
Haley G Gibbs, Tara McLernon, Rosemary Call, Katie Outten, Leigh Efird, Peter A Doyle, Elizabeth A Stuart, Nestoras Mathioudakis, Nicole Glasgow, Avadhut Joshi, Pravin George, Bob Feroli, Elizabeth K Zink
PURPOSE: Results of a quality-improvement project to enhance safeguards against "wrong-pen-to-patient" insulin pen errors by permitting secure bedside storage of insulin pens are reported. METHODS: A cluster-randomized controlled evaluation was conducted at an academic medical center to assess adherence with institutional policy on insulin pen storage before and after implementation of a revised policy allowing pen storage in locking boxes in patient rooms. In phase 1 of the study, baseline data on policy adherence were captured for 8 patient care units (4 designated as intervention units and 4 designated as control units)...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29222210/double-duodenal-perforation-following-foreign-body-ingestion
#15
Andrew W Gardner, Rami W Radwan, Miles C Allison, Rhodri J Codd
Intentional ingestion of a foreign body in adults is a rare clinical presentation. This case is one of a 27-year-old Sudanese man who presented having swallowed a ballpoint pen intentionally. Clinical examination and plain chest radiograph exhibited no signs indicative of perforation with only a raised C reactive protein identified on blood tests. Subsequent gastroscopy revealed that the pen had simultaneously perforated the duodenum at both D1 and D3 requiring removal via a laparotomy. The patient fully recovered and was discharged 2 weeks postoperatively following psychiatric input...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29218568/peer-education-group-intervention-to-reduce-psychological-insulin-resistance-a-pilot-mixed-method-study-in-a-chinese-population
#16
Ka Yan Or, Benjamin Hoi-Kei Yip, Chi Hang Lau, Hing Han Chen, Yuk Wah Chan, Kam Pui Lee
INTRODUCTION: Psychological insulin resistance (PIR) is common among type II diabetes (DM) patients. Although interventions to reduce PIR have been suggested, there is no standardized intervention to reduce PIR. This trial aimed to assess the preliminary effectiveness of a well-structured interventional patient group (for sample size calculation for larger trials), as well as the acceptability and feasibility of this intervention group. METHODS: This study used a quasi-experimental, mixed-method approach...
December 7, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29217934/the-prevalence-of-antibiotic-resistant-diarrhogenic-bacterial-species-in-surface-waters-south-eastern-nigeria
#17
Stanley C Onuoha
Background: This study assessed the bacteriological qualities of surface waters in Afikpo, between April and September 2016. Methods: Surface water samples were collected from three streams for bacteriological analysis. Bacteria species were isolated using standard microbiological and biochemical techniques. Antibiotic susceptibility study was carried out using Kirby Bauer disc diffusion method. Results: The result of the mean heterotrophic bacteria count from the streams showed that Okpu stream had 209...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29215790/inhibition-of-fucosylation-in-human-invasive-ductal-carcinoma-reduces-e-selectin-ligand-expression-cell-proliferation-and-erk1-2-and-p38-mapk-activation
#18
M A Carrascal, M Silva, J S Ramalho, C Pen, M Martins, C Pascoal, C Amaral, I Serrano, M J Oliveira, R Sackstein, P A Videira
Breast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A ), and α-1,3/4-fucosyltransferases in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their role(s) in breast carcinogenesis is still unknown. Here, we aimed to define the contribution of the fucosylated structures, including sLeX/A , to cell adhesion, cell signaling and proliferation in invasive ductal carcinomas (IDC), the most frequent type of breast cancer...
December 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29212271/inhibition-of-astrocytic-activity-alleviates-sequela-in-acute-stages-of-intracerebral-hemorrhage
#19
Cheng-Di Chiu, Nai-Wei Yao, Jeng-Hung Guo, Chiung-Chyi Shen, Hsu-Tung Lee, You-Pen Chiu, Hui-Ru Ji, Xianxiu Chen, Chun-Chung Chen, Chen Chang
Neurological deterioration of intracerebral hemorrhage (ICH) mostly occurs within the first 24 hours. Together with the microglia/macrophages (MMΦ), astrocytes are important cell population responsible for many brain injuries but rarely being highlighted in acute stage of ICH. In present study, we induced rats ICH either by collagenase or autologous blood injection. Experimental groups were classified as vehicle or Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3) treatment group (n = 9, each group)...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211892/evaluation-of-the-effect-of-live-lasota-newcastle-disease-virus-vaccine-as-primary-immunization-on-immune-development-in-broilers
#20
J C S Martinez, W K Chou, L R Berghman, J B Carey
Newcastle disease remains a major concern to the poultry industry; however, it can be managed with effective vaccination programs. The main objective of this study was to evaluate the effect of 2 1× doses of live LaSota strain Newcastle disease virus (NDV) vaccine administered oculo-nasally on d one and 21 on development of humoral and cell-mediated immune response in broilers, and to compare different immunization schedules. Two experiments were conducted. In Experiment I (n = 320), Ross 308 birds were randomly assigned to an unvaccinated control group or vaccinated treatment...
December 2, 2017: Poultry Science
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