Laura Ceccarelli, Lorenzo Verriello, Giada Pauletto, Mariarosaria Valente, Leopoldo Spadea, Carlo Salati, Marco Zeppieri, Tamara Ius
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder, characterized by progressive loss of both upper and lower motor neurons, resulting in clinical features such as muscle weakness, paralysis, and ultimately, respiratory failure. Nowadays, there is not effective treatment to reverse the progression of the disease, that leads to death within 3-5 years after the onset. Nevertheless, the induced pluripotent stem cells (iPS) technology could be the answer, providing disease modelling, drug testing, and cell-based therapies for this pathology...
March 20, 2024: Frontiers in Bioscience (Landmark Edition)