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https://www.readbyqxmd.com/read/29684538/molecular-cloning-characterization-and-expression-analysis-of-c-ebp-%C3%AE-%C3%AE-and-%C3%AE-in-adipose-related-tissues-and-adipocyte-of-duck-anas-platyrhynchos
#1
Jiamin Qiu, Wanxia Wang, Shenqiang Hu, Yushi Wang, Wenqiang Sun, Jiwei Hu, Jiwen Wang
CCAAT/enhancer binding protein α, β, δ (C/EBP α, β, δ) are essential transcriptional factors in regulating adipose development. However, information about their sequence characteristics and functions during adipocyte development still remains scarce in birds. In present study, we found that duck C/EBP α, β, δ differed in their phosphorylation sites and low complexity regions (LCRs) among their orthologs and paralogs. Phylogenetic analysis showed that C/EBP α, β, δ had different evolutionary patterns, and each of duck C/EBP α, β, δ was strikingly diverged from orthologs of other Aves...
April 20, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29684433/oxygen-titration-after-resuscitation-from-out-of-hospital-cardiac-arrest-a-multi-centre-randomised-controlled-pilot-study-the-exact-pilot-trial
#2
Janet E Bray, Cindy Hein, Karen Smith, Michael Stephenson, Hugh Grantham, Judith Finn, Dion Stub, Peter Cameron
INTRODUCTION: Recent studies suggest the administration of 100% oxygen to hyperoxic levels following return-of-spontaneous-circulation (ROSC) post-cardiac arrest may be harmful. However, the feasibility and safety of oxygen titration in the prehospital setting is unknown. We conducted a multi-centre, phase-2 study testing whether prehospital titration of oxygen results in an equivalent number of patients arriving at hospital with oxygen saturations SpO2 ≥ 94%. METHODS: We enrolled unconscious adults with: sustained ROSC; initial shockable rhythm; an advanced airway; and an SpO2 ≥ 95%...
April 20, 2018: Resuscitation
https://www.readbyqxmd.com/read/29683363/cardiovascular-autonomic-response-to-orthostatic-stress-under-hypoxia-in-patients-with-spinal-cord-injury
#3
Shu-Chun Huang, Kuo-Cheng Liu, Alice M K Wong, Shih-Chieh Chang, Jong-Shyan Wang
Huang, Shu-Chun, Kuo-Cheng Liu, Alice M.K. Wong, Shih-Chieh Chang, and Jong-Shyan Wang. Cardiovascular autonomic response to orthostatic stress under hypoxia in patients with spinal cord injury. High Alt Med Biol. 00:000-000, 2018. AIMS: Determining whether systemic hypoxia aggravates the severity of autonomic cardiovascular dysfunction in orthostatic stress among patients with spinal cord injuries (SCIs). METHODS: Twenty-four male patients with chronic SCI whose neurological levels were above T6 were recruited...
April 23, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29683104/association-of-epicardial-fat-thickness-with-clinical-and-polysomnographic-parameters-in-non-obese-obstructive-sleep-apnoea-patients
#4
S Derin, I Altun, S Koseoglu, C Sahin, M Yilmaz, F Akin, M Sahan
OBJECTIVES: This study aimed to investigate the relationship of epicardial fat thickness with severity of obstructive sleep apnoea, and clinical and polysomnographic parameters, and to determine independent predictors for epicardial fat thickness. METHODS: A total of 84 patients with a body mass index of less than 30 kg/m2 and suspected sleep-disordered breathing were included in the study. The correlations of epicardial fat thickness with polysomnographic and clinical data, and severity of obstructive sleep apnoea, were investigated...
April 23, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29680431/occurrence-of-nocturia-is-not-mediated-by-nocturnal-hypoxia-length-and-severity-in-patients-with-sleep-disordered-breathing
#5
P Finamore, S Scarlata, A Laudisio, F Galdi, M E Pipita, I Chiarella, R Giua, L Cortese, C Rivera, R Antonelli Incalzi
BACKGROUND: Nocturia is highly prevalent in subjects with respiratory sleep disturbances (ie obstructive sleep apnea). The aim of our study is to evaluate whether nocturia is associated with intermittent desaturations or hypoxia length and severity in people undergoing polysomnography. METHODS: We recruited 275 consecutive subjects attending the outpatient clinic for respiratory diseases at Campus Bio-Medico Teaching Hospital. Nocturia was defined as a self-reported voiding frequency ≥ two per night...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680422/effect-of-kidney-transplantation-on-sleep-disordered-breathing-in-patients-with-end-stage-renal-disease-a-polysomnographic-study
#6
Sanjiv Mahajan, Kartik Gupta, Sanjeev Sinha, Atul Malhotra, Sandeep Mahajan
BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with end-stage renal disease (ESRD). SDB is associated with comorbidities such as hypertension, diabetes mellitus, and obesity, interplaying with metabolic derangements in the form of uremia, acidosis, and hypervolemia. Renal transplant has been observed to correct most of these metabolic derangements and to control progression of comorbidities. While SDB is highly prevalent among patients in the pretransplant stage, it remains to be seen whether the beneficial aspects of transplant are extended to improvement in SDB in patients with ESRD...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29676667/evaluating-the-clinical-value-of-the-hypoxia-burden-index-in-patients-with-obstructive-sleep-apnea
#7
Fengwei Chen, Kun Chen, Cheng Zhang, Xue Chen, Junjun Huang, Peng Jia, Jing Ma, Jue Zhang, Jing Fang, Guangfa Wang
PURPOSE: We aimed to develop a novel index, the hypoxia burden index (HBI), that reflects the degree and duration of oxygen desaturation, and to determine whether this index is better than the apnea hypopnea-index (AHI) for evaluating obstructive sleep apnea (OSA) and cardiovascular diseases morbidities. METHODS: We retrospectively analyzed 459 adult subjects who underwent overnight polysomnography (PSG) in this study. The HBI was calculated by dividing the total desaturation area of SpO2 below 90% by the TST measured in seconds...
April 20, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29676149/biosynthesis-of-polyunsaturated-fatty-acids-in-the-razor-clam-sinonovacula-constricta-characterization-of-%C3%AE-5-and-%C3%AE-6-fatty-acid-desaturases
#8
Zhaoshou Ran, Jilin Xu, Kai Liao, Shuang Li, Shubing Chen, Xiaojun Yan
To investigate the endogenous LC-PUFA biosynthetic ability in Sinonovacula constricta, fatty acid desaturases (Fads) of this bivalve were cloned and characterized in current study, namely Scfad5a, Scfad5b and Scfad6. Meanwhile, the tissue distributions of S. constricta Fads and fatty acids (FAs) were examined. Heterologous expression in yeasts confirmed that Scfad5a and Scfad5b were both Δ5 Fads, while Scfad6 was a Δ6 Fad. However, compared with Fads in other organisms, the desaturation activities of S. constricta Fads were relatively low (especially for Scfad6), indicating an adaptation to living conditions...
April 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29664049/increased-serum-cystatin-c-in-early-parkinson-s-disease-with-objective-sleep-disturbances
#9
Kang-Ping Xiong, Yong-Ping Dai, Jing Chen, Jin-Min Xu, Yi Wang, Ping Feng, Shou-Jiang You, Chun-Feng Liu
Background: Sleep disturbance is one of the major non-motor symptoms which cause the disability of Parkinson's disease (PD) patients. Cystatin C (CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate. Previous studies have reported altered CysC levels in neurodegenerative disorders and sleep disorders. This study aimed to explore the correlations of serum CysC levels and objective sleep disturbances in early PD. Methods: We recruited 106 early PD patients and 146 age- and sex-matched controls...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29664048/effect-of-rapid-eye-movement-sleep-behavior-disorder-on-obstructive-sleep-apnea-severity-and-cognition-of-parkinson-s-disease-patients
#10
Jun-Ying Huang, Jin-Ru Zhang, Yun Shen, Hui-Jun Zhang, Yu-Lan Cao, Cheng-Jie Mao, Ya-Ping Yang, Jing Chen, Chun-Feng Liu, Jie Li
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) and obstructive sleep apnea (OSA) are the most common sleep disorders in Parkinson's disease (PD). The aim of this study was to identify whether RBD could alleviate OSA severity in PD patients and its effect on cognitive impairment. Methods: From February 2014 to May 2017, we recruited 174 PD patients from the Second Affiliated Hospital of Soochow University, all of whom underwent polysomnography (PSG)...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29657077/reprint-of-marine-omega-3-fatty-acids-in-the-prevention-of-cardiovascular-disease
#11
Trevor A Mori
Omega-6 (ω6) and omega-3 (ω3) fatty acids are two classes of dietary polyunsaturated fatty acids derived from linoleic acid (18:2ω6) and α-linolenic acid (18:3ω3), respectively. Enzymatic metabolism of linoleic and α-linolenic acids generates arachidonic acid (20:4ω6) and eicosapentaenoic acid (20:5ω3; EPA), respectively, both of which are substrates for enzymes that yield eicosanoids with multiple and varying physiological functions. Further elongation and desaturation of EPA yields the 22-carbon fatty acid docosahexaenoic acid (22:6ω3; DHA)...
April 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29656945/ketamine-versus-ketamine-pluses-atropine-for-pediatric-sedation-a-meta-analysis
#12
REVIEW
Jiaxiao Shi, Ang Li, Zhijian Wei, Yang Liu, Cong Xing, Hongyu Shi, Han Ding, Dayu Pan, Guangzhi Ning, Shiqing Feng
OBJECTIVES: The application of atropine for pediatric sedation in the emergency department remains controversial. Our objective was to perform a comprehensive review of the literature and assess the clinical indexes in groups with and without atropine use. METHODS: PubMed, EMBASE, and the Cochrane Library were searched for randomized and non-randomized studies that compared ketamine and ketamine plus atropine for pediatric sedation. The risk ratio with 95% confidence interval was calculated using either a fixed- or random-effects model according to the value of I2 ...
April 5, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29655763/sleeping-oxygen-saturation-rapid-eye-movement-sleep-and-the-adaptation-of-postprandial-metabolic-function-in-insulin-sensitive-and-resistant-individuals-without-diabetes
#13
Karin A Garcia, William K Wohlgemuth, Ele Ferrannini, Andrea Mari, Alex Gonzalez, Armando J Mendez, Roberto Bizzotto, Jay S Skyler, Neil Schneiderman, Barry E Hurwitz
AIMS: Sleeping oxygen saturation (SaO2 ) and sleep stage duration have been linked with prediabetic alterations but the pathogenic pathways are not well understood. This study of insulin sensitive and resistant adults examined the effect on postprandial metabolic regulation of repeated mixed-meal challenges of different carbohydrate loading. The aim was to examine whether the relationship between lower sleeping oxygen saturation (SaO2 ) and poorer fasting and postprandial metabolic function may be linked with reduced slow wave sleep (SWS) and rapid eye movement (REM) duration, independent of age, sex and total adiposity...
April 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29651484/rieske-non-heme-iron-dependent-oxygenases-catalyse-diverse-reactions-in-natural-product-biosynthesis
#14
Christopher Perry, Emmanuel L C de Los Santos, Lona M Alkhalaf, Gregory L Challis
Covering: up to the end of 2017The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to catalyse a range of transformations, including oxidative carbocyclisation, N-oxygenation, C-hydroxylation and C-C desaturation. Examples of such enzymes that have yet to be experimentally investigated are also briefly described and their likely functions are discussed...
April 13, 2018: Natural Product Reports
https://www.readbyqxmd.com/read/29649379/decrease-of-plasma-soluble-pro-renin-receptor-by-bariatric-surgery-in-patients-with-obstructive-sleep-apnea-and-morbid-obesity
#15
Tsuguo Nishijima, Koji Ohba, Shigeaki Baba, Testuya Kizawa, Keisuke Hosokawa, Fumiyo Endo, Yoshihiro Yamashiro, Akira Suwabe, Akira Sasaki, Kazuhiro Takahashi, Shigeru Sakurai
BACKGROUND: Plasma concentrations of soluble (pro)renin receptor [s(P)RR], which are elevated in patients with obstructive sleep apnea (OSA), have not been studied in morbid obesity. The aim of this study is to clarify effects of bariatric surgery on plasma s(P)RR concentrations and identify associated factors for their changes in OSA patients with morbid obesity. METHODS: Twenty-three patients with OSA complicated by morbid obesity (10 men and 13 women; body mass index, 40...
March 20, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29649028/does-the-incidence-of-postoperative-complications-after-inguinal-hernia-repair-justify-hospital-admission-in-prematurely-and-term-born-infants
#16
Marina Massoud, A Y Rosalie Kühlmann, Monique van Dijk, Lonneke M Staals, Rene M H Wijnen, Joost van Rosmalen, Cornelius E J Sloots, Claudia M G Keyzer-Dekker
BACKGROUND: Postoperatively, young infants are admitted overnight in view of the risk for respiratory complications such as desaturation and apnea. This risk seems much lower than previously reported. Until what age this risk persists, and which infants might actually qualify for day-care treatment, is unknown. METHODS: We retrospectively reviewed medical charts from preterm infants <45 weeks postconceptional age (PCA), 45-60 weeks PCA, and term infants <3 months admitted overnight after inguinal hernia repair, from January 2011 to December 2015 in a large tertiary children's hospital...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29643554/effectiveness-of-transnasal-humidified-rapid-insufflation-ventilatory-exchange-versus-traditional-preoxygenation-followed-by-apnoeic-oxygenation-in-delaying-desaturation-during-apnoea-a-preliminary-study
#17
Sunil Rajan, Nandhini Joseph, Pulak Tosh, Dilesh Kadapamannil, Jerry Paul, Lakshmi Kumar
Background and Aims: Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) during apnoea has shown to delay desaturation. The primary objective was to compare time to desaturate to <90% during apnoea with THRIVE versus traditional preoxygenation followed by apnoeic oxygenation. Methods: This prospective, randomised, single-blinded study was conducted in 10 adult patients presenting for direct laryngoscopy under general anaesthesia without endotracheal intubation...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29629931/magnetic-resonance-imaging-in-neurocritically-ill-patients-who-fails-and-how
#18
Joong-Goo Kim, Myung-Ah Ko, Han-Bin Lee, Sang-Beom Jeon
OBJECTIVES: Performing magnetic resonance imaging (MRI) in neurocritically ill patients is challenging because it often requires sedation and withholding care in the neurological intensive care unit. This study investigated the incidence of and reasons for failed or complicated MRI (MRI-FC) in such patients. METHODS: A consecutive series of 218 neurocritically ill patients who underwent brain MRI were retrospectively evaluated. Failed or complicated MRI included failure to obtain all ordered sequences, unscheduled sedative administration, decrease in oxygen saturation to less than 90%, hypotension (≥40-mm Hg decrease and/or use of inotropic agents), and cardiac or respiratory arrest...
April 6, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29628967/augmentation-of-respiratory-muscle-activities-in-preterm-infants-with-feeding-desaturation
#19
Dong Rak Kwon, Gi Young Park, Ji Eun Jeong, Woo Taek Kim, Eun Joo Lee
Purpose: Frequent desaturation due to immature incoordination of suck-swallow-breathing in preterm infants can influence multiple organs such as the heart, lungs, and brain, which can then affect growth and development. Most notably in preterm infants, feeding desaturation may even affect pulmonary function during gavage feeding. Because respiratory muscle activities may reflect the work required during respiration, we evaluated the differences in these activities between full-term and preterm infants with feeding desaturation, and investigated the correlations with clinical variables...
March 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29628833/efficacy-and-safety-of-dexmedetomidine-infusion-for-patients-undergoing-awake-craniotomy-an-observational-study
#20
Charu Mahajan, Girija Prasad Rath, Gyaninder Pal Singh, Nitasha Mishra, Suman Sokhal, Parmod Kumar Bithal
Background: The goal of awake craniotomy is to maintain adequate sedation, analgesia, respiratory, and hemodynamic stability and also to provide a cooperative patient for neurologic testing. An observational study carried out to evaluate the efficacy of dexmedetomidine sedation for awake craniotomy. Materials and Methods: Adult patients with age >18 year who underwent awake craniotomy for intracranial tumor surgery were enrolled. Those who were uncooperative and had difficult airway were excluded from the study...
April 2018: Saudi Journal of Anaesthesia
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