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https://www.readbyqxmd.com/read/28811219/trinucleotide-repeat-containing-6c-tnrc6c-is-essential-for-microvascular-maturation-during-distal-airspace-sacculation-in-the-developing-lung
#1
Hua Guo, Yana Kazadaeva, Fabian E Ortega, Manjunath N Swamy, Tushar J Desai
GW182 (also known asTNRC6) family members are critically involved in the final effector phase of miRNA-mediated mRNA repression. The three mammalian paralogs, TNRC6a, b and c, are thought to be redundant based on Argonaute (Ago) binding, tethering assays, and RNAi silencing of individual members in cell lines. To test this idea, we generated TNRC6a, b and c knockout mice. TNRC6a mutants die at mid-gestation, while b- and c- deleted mice are born at a Mendelian ratio. However, the majority of TNRC6b and all TNRC6c mutants die within 24 hours after birth, the latter with respiratory failure...
August 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28810330/-the-function-of-nlrp1-in-noninfectious-pulmonary-injury-following-allogeneic-hematopoietic-stem-cell-transplantation
#2
M F Li, W Li, L Ding, Y L Wu, L Liu, W Ju, J L Qiao, K L Xu, L Y Zeng
Objective: To explore the function of NLRP1 in noninfectious pulmonary injury (nonIPI) after allogeneic stem cell transplantation (allo-HSCT) . Methods: In this study, we established the model of allo-HSCT with C57BL/6 and NLRP(-/-) mouse as recipients. Chimera rate was measured by flow cytometry. The HE staining was used to observe the pathology changes in the lungs. NLRP1 and relevant inflammatory proteins were measured by Western Blot. Results: On the day 14 after allo-HSCT, the chimera rate was more than 96%, HSCs of donors had been successfully transplanted into recipients...
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28807337/evaluation-of-cd43-expression-in-non-hematopoietic-malignancies
#3
Bjorn H Batdorf, Steven H Kroft, Paul R Hosking, Alexandra M Harrington, Alexander C Mackinnon, Horatiu Olteanu
OBJECTIVES: CD43 is normally expressed only on the surface of leukocytes, and is considered a sensitive and specific marker for hematologic malignancies. As such, it may have diagnostic utility in confirming hematolymphoid lineage in cases that are negative for CD45. Aberrant CD43 expression has been described in non-hematopoietic tumors, although literature data on this topic is variable and sometimes contradictory. To clarify and expand on existing literature findings, we evaluated CD43 expression by immunohistochemistry (IHC) in a large cohort (307) of non-hematopoietic neoplasms, including poorly differentiated malignancies...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28801414/transformation-of-mortality-in-a-remote-australian-aboriginal-community-a-retrospective-observational-study
#4
Wendy E Hoy, Susan Anne Mott, Beverly June McLeod
OBJECTIVES: To describe trends in ages and causes of death in a remote-living Australian Aboriginal group over a recent 50-year period. DESIGN: A retrospective observational study, from 1960 to 2010, of deaths and people starting dialysis, using data from local clinic, parish, dialysis and birthweight registers. SETTING: A remote island community in the Top End of Australia's Northern Territory, where a Catholic mission was established in 1911...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800319/mir-503-3p-induces-apoptosis-of-lung-cancer-cells-by-regulating-p21-and-cdk4-expression
#5
Yi Sun, Li Li, Shigang Xing, Yinghua Pan, Yunxiang Shi, Linghua Zhang, Qiang Shen
Studies have shown that microRNAs (miRNAs) can promote or suppress tumor growth and therefore act as targets for cancer therapy. Hsa-miR-503-5p, a mature miRNA derived from 5' ends of pre-miR-503, has been proved to regulate cell proliferation, transformation, migration and invasion. However, the biological function of miR-503-3p derived from 3' ends of pre-miR-503 has never been reported. In current study, we found that miR-503-3p inhibits lung cancer cell viability and induces cell apoptosis. To better understand the molecular mechanism underlying the miR-503-3p participating in this process, PCR array and RNA-sequencing (RNA-seq) were performed and some differential expression genes were discovered between NC and miR-503-3p treated groups...
July 28, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28799656/review-of-the-effects-of-manufactured-nanoparticles-on-mammalian-target-organs
#6
REVIEW
Tianshu Wu, Meng Tang
Nanotechnology had matured significantly during the last two decades as it has transitioned from bench top science to applied technology. Even though the issue of safety of nanotechnology has been raised nearly one decade ago, the rapid progress in development and use of nanomaterials has not yet been matched by toxicological investigations. Many recent studies have simply outlined the toxic effects of nanoparticles (NPs), but few have systematically addressed their potentially adverse biological effects on target organs...
August 11, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28795263/dynamic-distribution-and-tissue-tropism-of-avian-encephalomyelitis-virus-isolate-xy-q-1410-in-experimentally-infected-korean-quail
#7
Lili Fan, Zhijun Li, Jiali Huang, Zengqi Yang, Sa Xiao, Xinglong Wang, Ruyi Dang, Shuxia Zhang
Avian encephalomyelitis (AE) is an important infectious poultry disease worldwide that is caused by avian encephalomyelitis virus (AEV). However, to date, the dynamic distribution of AEV in quails has not been well described. Quantitative real-time polymerase chain reaction (qPCR) and immunohistochemistry (IHC) assays were used to investigate the dynamic distribution and tissue tropism of AEV in experimentally infected Korean quail. AEV was detected in the cerebrum, cerebellum, proventriculus, intestine, liver, pancreas, spleen, bursa, lung and kidney as early as 3 days post-infection (dpi)...
August 9, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28794967/pleural-effusion-as-a-rare-manifestation-of-mediastinal-teratoma-a-case-report
#8
Ebrahim Razi, Aida Imani, Iman Ansari, Tehereh Khamechian, Abdolhossein Davoodabadi
Pleural effusion as one of the most common manifestations of pulmonary diseases is a rare symptom of anterior mediastinal teratoma that might mislead general physicians. In this study we report a rare case of pleural effusion and anterior mediastinal teratoma accompanying each other. The patient was a 21-year-old woman who suffered from dyspnea, cough, fever and manifestations of pleural effusion were obvious in chest X Ray (CXR). Computed tomography scan showed a cystic mass with lipid component. After thoracotomy, a mass was taken out from medial lobe of right lung and the results of pathology showed the mature mediastinal teratoma...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28793908/transcriptomic-analysis-comparing-mouse-strains-with-extreme-total-lung-capacities-identifies-novel-candidate-genes-for-pulmonary-function
#9
Leema George, Ankita Mitra, Tania A Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D Leikauf, Koustav Ganguly
BACKGROUND: Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice. We identified seven lung function quantitative trait loci (QTL: Lfnq1-Lfnq7) in backcross/intercross mice derived from these inbred strains. We further demonstrated, superoxide dismutase 3, extracellular (Sod3), Kit oncogene (Kit) and secreted phosphoprotein 1 (Spp1) located on these Lfnqs as lung function determinants...
August 9, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28780900/results-from-a-clinical-trial-evaluating-the-efficacy-of-real-time-body-surface-visual-feedback-in-reducing-patient-motion-during-lung-cancer-radiotherapy
#10
Gareth J Price, Corinne Faivre-Finn, Julia Stratford, Sheena Chauhan, Michelle Bewley, Laura Clarke, Corinne N Johnson, Christopher J Moore
INTRODUCTION: Optical surface measurement devices are a maturing technology in radiotherapy. The challenge for such devices is to demonstrate how they can improve clinical care. We present results from a phase 1 clinical trial designed to test the hypothesis that if presented with live data from a novel optical measurement device, showing their deviation from an ideal radiotherapy treatment position, patients will be able to better control their motion and increase their geometrical conformance...
August 7, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28780788/-therapeutic-effect-of-mir-489-in-a-mouse-model-of-silica-induced-matured-pulmonary-fibrosis
#11
S X Jin, Q Y Wu, W W Yan, C H Ni
Objective: To explore the potential therapeutic role of miR-489 in silica-induced pulmonary fibrosis mouse models. Methods: A total of 32 C57BL/6 male mice were randomly divided into four groups: saline, silica, silica plus miRNA control and silica plus miR-489 agomir (n=8 in each group) . The mice were instilled with silica particles suspended in saline or sterile saline intratracheally. Subsequently, miR-489 agomir or miRNA control was injected via the tail vein into each mouse at days 28, 35, 42 and 49, the miR-489 levels, histological examination, collagen deposition, fibrotic biomarkers (E-cadherin, α-SMA, Vimentin, Fibronectin) and transforming growth factor-β(1) (TGF-β(1)) protein levels in mouse lung tissues were measured...
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28773906/novel-resorbable-and-osteoconductive-calcium-silicophosphate-scaffold-induced-bone-formation
#12
Patricia Ros-Tárraga, Patricia Mazón, Miguel A Rodríguez, Luis Meseguer-Olmo, Piedad N De Aza
This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped pores (0.5-1.5 mm = were prepared). The scaffold acted as a physical support where cells with osteoblastic capability were found to migrate, develop processes, and newly immature and mature bone tissue colonized on the surface (initially) and in the material's interior...
September 20, 2016: Materials
https://www.readbyqxmd.com/read/28769054/an-alternative-microrna-mediated-post-transcriptional-regulation-of-gadd45a-by-p53-in-human-non-small-cell-lung-cancer-cells
#13
Jie Li, Jie Dong, Shaohua Li, Wei Xia, Xueting Su, Xingliang Qin, Ying Chen, Hongmei Ding, Hui Li, Aixue Huang, Chenjun Bai, Tongnan Hu, Chenglong Wang, Bingfeng Chu, Ningsheng Shao
GADD45A (growth arrest and DNA damage inducible alpha), a stress response gene induced by genotoxic and nongenotoxic stresses, is implicated in various key processes, including the control of cell cycle checkpoints and DNA repair. The expression of GADD45A is directly regulated by numerous transcription factors, with p53 being the most representative. Moreover, post-transcriptional regulation also plays a role in GADD45A expression. However, little is known about the regulatory effects of microRNAs (miRNAs) on GADD45A expression...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28767421/periostin-promotes-epithelial-mesenchymal-transition-via-the-mapk-mir-381-axis-in-lung-cancer
#14
Wei-Wei Hu, Po-Chun Chen, Jun-Ming Chen, Yue-Ming Wu, Po-Yi Liu, Chih-Hao Lu, Yu-Feng Lin, Chih-Hsin Tang, Chia-Chia Chao
Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a multifunctional cytokine that signals between the cell and the extracellular matrix. Periostin plays an important role in tumor development and is involved in carcinoma cell epithelial-mesenchymal transition (EMT), whereby mature epithelial cells undergo phenotypic morphological changes and become invasive, motile cells. Here, we discuss the molecular mechanisms involved in periostin-induced promotion of EMT in lung cancer cells. Online TCGA datasets demonstrate the prognostic relevance of periostin in lung cancer; a higher periostin level correlates with poor overall survival...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765557/the-voltage-dependent-anion-channels-vdac-of-mycobacterium-avium-phagosome-are-associated-with-bacterial-survival-and-lipid-export-in-macrophages
#15
Lia Danelishvili, Jessica J J Chinison, Tuan Pham, Rashmi Gupta, Luiz E Bermudez
Mycobacterium avium subsp. hominissuis is associated with infection of immunocompromised individuals as well as patients with chronic lung disease. M. avium infects macrophages and actively interfere with the host killing machinery such as apoptosis and autophagy. Bacteria alter the normal endosomal trafficking, prevent the maturation of phagosomes and modify many signaling pathways inside of the macrophage by secreting effector molecules into the cytoplasm. To investigate whether M. avium needs to attach to the internal surface of the vacuole membrane before releasing efferent molecules, vacuole membrane proteins were purified and binding to the surface molecules present in intracellular bacteria was evaluated...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765216/key-role-of-the-scavenger-receptor-marco-in-mediating-adenovirus-infection-and-subsequent-innate-responses-of-macrophages
#16
Mareike D Maler, Peter J Nielsen, Nicole Stichling, Idan Cohen, Zsolt Ruzsics, Connor Wood, Peggy Engelhard, Maarit Suomalainen, Ildiko Gyory, Michael Huber, Joachim Müller-Quernheim, Wolfgang W A Schamel, Siamon Gordon, Thilo Jakob, Stefan F Martin, Willi Jahnen-Dechent, Urs F Greber, Marina A Freudenberg, György Fejer
The scavenger receptor MARCO is expressed in several subsets of naive tissue-resident macrophages and has been shown to participate in the recognition of various bacterial pathogens. However, the role of MARCO in antiviral defense is largely unexplored. Here, we investigated whether MARCO might be involved in the innate sensing of infection with adenovirus and recombinant adenoviral vectors by macrophages, which elicit vigorous immune responses in vivo Using cells derived from mice, we show that adenovirus infection is significantly more efficient in MARCO-positive alveolar macrophages (AMs) and in AM-like primary macrophage lines (Max Planck Institute cells) than in MARCO-negative bone marrow-derived macrophages...
August 1, 2017: MBio
https://www.readbyqxmd.com/read/28760610/macrophage-derived-insulin-like-growth-factor-1-affects-influenza-vaccine-efficacy-through-the-regulation-of-immune-cell-homeostasis
#17
Il-Sub Yoon, Hyelim Park, Hye-Won Kwak, Yong Woo Jung, Jae-Hwan Nam
The level of antibody production induced by a vaccine involves a variety of host factors. One of these, insulin-like growth factor-1 (IGF-1), plays an important role in lymphocyte maturation and antibody expression. Here, we investigated the role of macrophage-derived IGF-1 in the induction of influenza vaccine-specific antibodies using macrophage-derived IGF-1 gene knockout (MIKO) mice. The titers of vaccine-specific total immunoglobulin G (IgG) and IgG1 after immunization were about two- to fourfold lower in MIKO mice than in WT mice...
July 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28759122/differential-effects-of-late-gestation-maternal-overnutrition-on-the-regulation-of-surfactant-maturation-in-fetal-and-postnatal-life
#18
Mitchell C Lock, Erin V McGillick, Sandra Orgeig, I Caroline McMillen, Beverly S Mühlhäusler, Song Zhang, Janna L Morrison
With the increasing incidence of obesity worldwide, the proportion of women entering pregnancy overweight or obese has increased dramatically. The fetus of an overnourished mother experiences numerous metabolic changes that may modulate lung development and hence successful transition to air-breathing at birth. We used a sheep model of maternal late gestation overnutrition (LGON; from 115 d gestation, term 147 ± 3 d) to determine the effect of exposure to an increased plane of nutrition in late gestation on lung development in the fetus (at 141 d gestation) and the lamb (30 d after birth)...
July 31, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28752463/semiquantitation-of-monomer-and-polymer-alpha-1-antitrypsin-by-centrifugal-separation-and-assay-by-western-blot-of-soluble-and-insoluble-components
#19
Keith S Blomenkamp, Jeffrey H Teckman
Alpha-1 antitrypsin (a1AT) deficiency, in its classical form, is an autosomal recessive disease associated with an increased risk of liver disease in adults and children, and with lung disease in adults. The vast majority of liver disease is associated with homozygosity for the Z mutant allele, also called PiZZ. This homozygous allele synthesizes large quantities of a1AT mutant Z protein in the liver, but the mutant protein also folds improperly during biogenesis. As a result, approximately 85% of the molecules are retained within the hepatocytes instead of being appropriately secreted...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28751157/end-of-life-decision-making-for-parents-of-extremely-preterm-infants
#20
Manya J Hendriks, Andrea Abraham
OBJECTIVE: To explore parental attitudes and values in the end-of-life decision-making process of extremely preterm infants (gestational age < 28 weeks). DESIGN: Hermeneutically oriented qualitative research design with in-depth interviews. SETTING: Level III NICU in Switzerland. PARTICIPANTS: Purposive sample of seven couples, five mothers, and one father (20 parents). METHODS: Qualitative content analysis was used to categorize and interpret themes from parents' narratives...
July 24, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
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