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central lymph node thyroid carcinoma

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https://www.readbyqxmd.com/read/29032663/number-of-metastatic-lymph-nodes-and-ratio-of-metastatic-lymph-nodes-to-total-number-of-retrieved-lymph-nodes-are-risk-factors-for-recurrence-in-patients-with-clinically-node-negative-papillary-thyroid-carcinoma
#1
Chuan-Ming Zheng, Yong Bae Ji, Chang Myeon Song, Ming-Hua Ge, Kyung Tae
Objectives: The number of metastatic lymph nodes (LNs) and the ratio between the number of metastatic LNs and the total number of retrieved LNs (the LN ratio [LNR]) have been proposed as risk factors for recurrence of papillary thyroid carcinoma (PTC). However, the significance of the number of LNs and the LNR in patients with clinically node negative PTC has not been clearly determined. The purpose of this study is to evaluate their significance. Methods: We retrospectively analyzed 382 patients with PTC who had undergone total thyroidectomy with prophylactic central neck dissection (CND) between January 2000 and December 2010...
October 17, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29022644/assessment-of-risk-factors-in-metastatic-recurrent-tall-cell-variant-of-papillary-thyroid-carcinoma
#2
Kursat Okuyucu, Engin Alagoz, Semra Ince, Nuri Arslan
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor. A great majority of the cases live a disease-free life with quite favorable prognosis. There are lots of variants of PTC and a few of them exhibit aggressive behaviour. Typical example is the tall cell variant (TCV). Patients experience a greater incidence of recurrence, nodal and extranodal metastases, tumor associated mortality than other variants of PTC. Studies related to TCV almost always compared it with its patient population of PTC according to risk factors and clinicopathologic features...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28979135/intraoperative-measurement-of-thyroglobulin-in-lymph-node-aspirates-for-the-detection-of-metastatic-papillary-thyroid-carcinoma
#3
Yizeng Wang, Yuanchao Liu, Xiaoning Wang, Xin Li, Ruoyu Jiang, Xianghui He
BACKGROUND: Among patients with papillary thyroid carcinoma (PTC), 30%-80% have cervical lymph node (LN) metastases, which are most commonly located in the central compartment. However, preoperative ultrasonography identifies malignant central compartment LNs in only 20%-30% of cases. We aimed to evaluate the diagnostic value of intraoperative thyroglobulin (Tg) measurement in fine-needle aspirates (FNA-Tg) of suspicious metastatic LNs. METHODS: In total, 75 patients (75 LNs) with PTC or suspected PTC were enrolled in this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28975988/risk-factors-for-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-cn0-a-study-of-273-resections
#4
M Li, X-Y Zhu, J Lv, K Lu, M-P Shen, Z-L Xu, Z-S Wu
OBJECTIVE: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma. PATIENTS AND METHODS: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. The predictive risk factors for CLNM were analyzed with respect to age, sex, tumor size, tumor multifocal, lymphadenectasis of lateral neck, capsular invasion, extra capsular spread (ECS), coexistence of chronic lymphocytic thyroiditis (Hashimoto thyroiditis, HT) and nodular goiter (NG), BRAFV600E mutation and subtype of papillary thyroid carcinoma (PTC)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28973144/risk-factors-associated-with-reoperation-and-disease-specific-mortality-in-patients-with-medullary-thyroid-carcinoma
#5
Eric J Kuo, Shonan Sho, Ning Li, Kyle A Zanocco, Michael W Yeh, Masha J Livhits
Importance: The association of initial neck dissection with recurrence in medullary thyroid carcinoma (MTC) has not been evaluated on a population level to date. Objective: To elucidate risk factors associated with reoperation in MTC and disease-specific mortality. Design, Setting, and Participants: A retrospective analysis was performed of hospital data obtained from the California Cancer Registry and the Office of Statewide Health Planning and Development from January 1, 1999, through December 31, 2012...
September 27, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28953664/risk-factors-of-hypoparathyroidism-following-total-thyroidectomy-with-central-lymph-node-dissection
#6
Anping Su, Bin Wang, Yanping Gong, Rixiang Gong, Zhihui Li, Jingqiang Zhu
The risk factors of hypoparathyroidism after total thyroidectomy (TT) with central lymph node dissection (CND) have not been completely defined. The aim of the study was to evaluate the risk factors of hypoparathyroidism after the surgery.We retrospectively reviewed our patients who underwent TT and CND (including lateral lymph node dissection) for thyroid carcinoma between January 2013 and June 2016. According to the postoperative serum levels of parathyroid hormone within 6 months, the patients were divided into normal, transient hypoparathyroidism, and permanent hypoparathyroidism groups...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28953211/clinical-response-to-radioactive-iodine-therapy-for-prophylactic-central-neck-dissection-is-not-superior-to-total-thyroidectomy-alone-in-cn0-patients-with-papillary-thyroid-cancer
#7
Lin Bai, Qiang Wen, Wenqi Zhang, Tianyu Yu, Lina Zhao, Ji Bin
OBJECTIVE: Prophylactic central neck dissection (pCND) is controversial in papillary thyroid carcinoma (PTC) without clinical positive lymph nodes. The aim of this study was to investigate the effect of radioactive iodine (RAI) therapy on the clinical outcome in clinically node-negative (cN0) PTC patients treated with total thyroidectomy (TT) alone or in combination with pCND. PATIENTS AND METHODS: One-hundred and sixty-seven cN0 PTC patients who underwent TT alone (TT) or in combination with pCND (TT+pCND) in our hospital from January 2014 to August 2015 were evaluated retrospectively...
September 25, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28934992/breast-cancer-metastases-to-the-thyroid-gland-an-uncommon-sentinel-for-diffuse-metastatic-disease-a-case-report-and-review-of-the-literature
#8
Agata M Plonczak, Aimee N DiMarco, Roberto Dina, Dorothy J Gujral, Fausto F Palazzo
BACKGROUND: Metastases to the thyroid are rare. The most common primary cancer to metastasize to the thyroid is renal cell carcinoma, followed by malignancies of the gastrointestinal tract, lungs, and skin, with breast cancer metastases to the thyroid being rare. Overall, the outcomes in malignancies that have metastasized to the thyroid are poor. There are no prospective studies addressing the role of surgery in metastatic disease of the thyroid. Isolated thyroidectomy has been proposed as a local disease control option to palliate and prevent the potential morbidity of tumor extension related to the airway...
September 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28911147/kif5b-ret-rearrangement-in-a-carcinoma-of-the-thyroid-gland-a-case-report-of-a-fatal-disease
#9
David Viola, Carlotta Giani, Salvatore Mazzeo, Clara Ugolini, Raffaele Ciampi, Eleonora Molinaro, Laura Agate, Nicla Borrelli, Antonio Chella, Gabriella Fontanini, Fulvio Basolo, Rossella Elisei
Background: The diffuse sclerosing variant of papillary thyroid cancer (DSV-PTC) is a rare variant of papillary thyroid cancer (PTC) with different clinicopathological features compared with conventional PTC. Case: An advanced DSV-PTC was diagnosed in a 39-year-old man. The radioiodine posttherapeutic whole-body-scan showed only an uptake in the central neck, whereas the computerized tomography showed multiple latero-cervical and mediastinum lymph node metastases, a single and spiculated lung lesion and multiple bilateral cerebellum metastases...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28906015/influence-of-coexistent-hashimoto-s-thyroiditis-on-the-extent-of-cervical-lymph-node-dissection-and-prognosis-in-papillary-thyroid-carcinoma
#10
Eyun Song, Min Ji Jeon, Suyeon Park, Mijin Kim, Hye-Seon Oh, Dong Eun Song, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim
OBJECTIVE: Previous studies did not focus on the differences in the extent of cervical lymph node (LN) dissection according to coexistent Hashimoto's thyroiditis (HT) in patients with papillary thyroid carcinoma (PTC) and its clinical impact. We aimed to determine whether extensive cervical LN dissection is responsible for favorable clinical outcomes in PTC patients with HT and whether coexistence of HT itself has an independent protective effect regardless of LN status. DESIGN: Retrospective cohort study PATIENTS: 1,369 patients with PTC who underwent total thyroidectomy with central compartment neck dissection...
September 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28895542/selective-sentinel-lymph-node-biopsy-in-papillary-thyroid-carcinoma-in-patients-with-no-preoperative-evidence-of-lymph-node-metastasis
#11
Óscar González, Carles Zafon, Enric Caubet, Amparo García-Burillo, Xavier Serres, José Manuel Fort, Jordi Mesa, Joan Castell, Isabel Roca, Santiago Ramón Y Cajal, Carmela Iglesias
INTRODUCTION: Lymphadenectomy is recommended during surgery for papillary thyroid carcinoma when there is evidence of cervical lymph node metastasis (therapeutic) or in high-risk patients (prophylactic) such as those with T3 and T4 tumors of the TNM classification. Selective sentinel lymph node biopsy may improve preoperative diagnosis of nodal metastases. OBJECTIVE: To analyze the results of selective sentinel lymph node biopsy in a group of patients with papillary thyroid carcinoma and no evidence of nodal involvement before surgery...
October 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28884426/thyroid-autoimmune-antibodies-in-patients-with-papillary-thyroid-carcinoma-a-double-edged-sword
#12
Chen-Tian Shen, Xin-Yun Zhang, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Quan-Yong Luo
PURPOSE: The relationship between thyroid autoimmunity and thyroid cancer remains controversial. The objective of this study is to comprehensively analyze the association between thyroid autoimmune antibodies and disease statuses of papillary thyroid carcinoma (PTC). METHODS: Patients were divided into different groups according to their final diagnoses after radioiodine therapy as well as their serum anti-thyroglobulin antibody (TgAb) and anti-thyroidperoxidase antibody (TPOAb) titers...
September 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28883010/laparoscopic-adrenalectomy-as-an-effective-approach-to-massive-bilateral-pheochromocytomas
#13
Diana Martins, Dírcea Rodrigues, Miguel Melo, Francisco Carrilho
Pheochromocytomas are catecholamine-secreting neoplasms, arising from adrenomedullary chromaffin cells. In type 2 multiple endocrine neoplasia (MEN2) syndrome, pheochromocytomas are usually benign but with predisposition to be bilateral (50%-80% of cases).The authors present the case of a young patient diagnosed with uncommonly large bilateral cystic pheochromocytomas and simultaneous detection of medullary thyroid carcinoma. Molecular testing confirmed germline RET codon C634 mutation, consistent with MEN2A syndrome...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28874622/predictors-of-central-lymph-node-metastasis-in-papillary-thyroid-cancer
#14
Huseyin Celik, Ozgur Akgul, Barıs Dogu Yıldız, Barıs Saylam, Mesut Tez
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland and although PTC has excellent prognosis, central lymph node (CLN) metastases are not uncommon. Studies have shown that CLN metastases are associated with an increased recurrence rate. The necessity for prophylactic CLN dissection (pCCND) in clinical lymph node negative (cN0) patients remains controversial. The aim of this study was to determine predictors of CLN metastases in cN0 PTC patients who underwent prophylactic CLN dissection...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28868775/clinical-analysis-of-the-factors-that-influence-disease-progression-of-differentiated-thyroid-carcinoma-in-children
#15
Yuan Qu, Rui Huang, Lin Li
AIM: To investigate the factors that influence disease progression of paediatric patients with differentiated thyroid carcinoma. METHODS: A total of 34 patients under 18 years of age with differentiated thyroid carcinoma (32 papillary and 2 follicular; 9 males and 25 females; 19 cases younger than 15 years old and 15 cases 15-18 years old) treated in our department from June 2009 to August 2015 were retrospectively reviewed. All of the patients underwent a total thyroidectomy or near-total thyroidectomy, central node dissection and/or lateral neck dissection, radioactive iodine treatment and thyroid-stimulating hormone suppressive therapy...
September 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28861856/role-of-sentinel-node-in-differentiated-thyroid-cancer-a-prospective-study-comparing-patent-blue-injection-technique-lymphoscintigraphy-and-the-combined-technique
#16
R Gelmini, M Campanelli, F Cabry, A Franceschetto, G Ceresini, L Ruffini, A Zaccaroni, P Del Rio
PURPOSE: The purpose of the present study was to evaluate the feasibility and reproducibility of the sentinel lymph node (SLNs) biopsy in differentiated thyroid cancer using patent blue injection, lymphoscintigraphy and the combined techniques. METHODS: Between January 2011 and January 2013, 82 consecutive patients were enrolled in our prospective multicentre study. Inclusion criteria were 18 years of age, preoperative diagnosis of differentiated thyroid carcinoma, no evidence of lymph node enlargement and multifocal neoplasm...
August 31, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28861609/mir-375-and-yap1-expression-profiling-in-medullary-thyroid-carcinoma-and-their-correlation-with-clinical-pathological-features-and-outcome
#17
Francesca Galuppini, Loris Bertazza, Susi Barollo, Elisabetta Cavedon, Massimo Rugge, Vincenza Guzzardo, Diana Sacchi, Sara Watutantrige-Fernando, Federica Vianello, Caterina Mian, Gianmaria Pennelli
Medullary thyroid cancer (MTC) is a tumor marked by an indolent growth for which few prognostic factors and therapeutic strategies are actually available. Different studies have recently appraised well-differentiated thyroid cancers are characterized by a dysregulation in different microRNA sets; however, only few of them investigated the role of miRNA expression in MTCs. In this study, we have assessed the miR-375 expression in a series of 130 MTCs (104 are sporadic and 26 familial) with a median follow-up of 39 months (range 1-138) and then we have correlated our results with the clinical-pathological features and the patients' outcome...
August 31, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28858110/predictors-of-lymph-nodes-posterior-to-the-right-recurrent-laryngeal-nerve-metastasis-in-patients-with-papillary-thyroid-carcinoma-a-retrospective-study
#18
Jiru Yuan, Jinghua Li, Xiaoyi Chen, Zhenwei Zhong, Zhengbo Chen, Ying Yin, Jialin Du, Shuzhen Cong, Zeyu Wu
The aim of this study was to identify the risk factors associated with lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) metastasis in patients with papillary thyroid carcinoma (PTC).A total of 81 PTC patients who underwent total/near-total thyroidectomy with LN-prRLN dissection in the Department of General Surgery at Guangdong General Hospital between June 2015 and August 2016 were assessed retrospectively. The relations of LN-prRLN metastasis with clinicopathologic characteristics of PTC were analyzed by univariate and multivariate logistic regression...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28822118/risk-factors-for-lateral-neck-recurrence-of-n0-n1a-papillary-thyroid-cancer
#19
Yehree Kim, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Current guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b. METHODS: The study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b...
August 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28782797/in-situ-preservation-of-the-inferior-parathyroid-gland-during-central-neck-dissection-for-papillary-thyroid-carcinoma
#20
J B Wang, K Wu, L H Shi, Y Y Sun, F B Li, L Xie
BACKGROUND: Postoperative hypocalcaemia due to dysfunction of the parathyroid glands is the most common complication after total thyroidectomy plus central neck dissection (CND). There is a lack of surgical techniques described to help preserve the inferior parathyroid gland in situ during CND. The objective of this study was to introduce the 'TBP layer' (layer of thymus-blood vessel-inferior parathyroid gland) concept for preserving the inferior parathyroid gland in situ during CND, and to evaluate its effectiveness...
October 2017: British Journal of Surgery
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