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central lymph node thyroid carcinoma

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https://www.readbyqxmd.com/read/29575838/-study-on-the-relationship-between-ultrasonographic-features-of-papillary-thyroid-carcinoma-and-central-cervical-lymph-node-metastasis
#1
X Q Wang, W Wei, X Wei, Y Xu, H L Wang, X J Xing, S Zhang
Objective: To investigate the correlation between ultrasonographic features of papillary thyroid carcinoma and central cervical lymph node metastasis. Methods: We retrospectively analyzed 486 patients with papillary thyroid carcinoma(PTC), pathologically confirmed after surgery in Tianjin Medical University Cancer Institute & Hospital. All patients were divided into central cervical lymph node metastasis group and non-metastasis group. No lateral cervical lymph node metastasis was found in preoperative ultrasonography and postoperative pathology...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29569965/analysis-of-risk-factors-for-cervical-lymph-node-metastases-in-patients-with-sporadic-medullary-thyroid-carcinoma
#2
Weina Fan, Cheng Xiao, Fusheng Wu
Objective Medullary thyroid carcinoma (MTC) is classified as either sporadic or inherited. This study was performed to analyze the risk factors for cervical lymph node metastases and predict the indication for prophylactic lateral neck dissection in patients with sporadic MTC. Methods Sixty-five patients with sporadic MTC were retrospectively reviewed. Univariate analysis with the chi-square test and multiple logistic regression analysis were applied to identify the clinicopathological features (sex, age, tumor size, number of tumor foci, capsule or vascular invasion, and others) associated with cervical lymph node metastases...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29562496/predictive-gene-signatures-of-nodal-metastasis-in-papillary-thyroid-carcinoma
#3
Kyu Young Choi, Jin Hwan Kim, Il Seok Park, Young Soo Rho, Gee Hwan Kwon, Dong Jin Lee
BACKGROUND: Cervical lymph node metastases (LNM) in papillary thyroid carcinomas (PTCs) are common and develop in approximately 30-80% of PTCs. The presence of cervical LNM significantly increases the rate of locoregional recurrence in PTCs. OBJECTIVE: To search for predictive gene signatures for nodal metastasis in PTCs. METHODS: We used unsupervised clustering with unbiased manner to compare molecular profiles between PTCs with nodal metastasis and PTCs without nodal metastasis using mRNA-seq of TCGA data...
March 1, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29550935/clinicopathologic-risk-factors-for-right-paraesophageal-lymph-node-metastasis-in-patients-with-papillary-thyroid-carcinoma
#4
Q A Yu, D K Ma, K P Liu, P Wang, C M Xie, Y H Wu, W J Dai, H C Jiang
OBJECTIVES: To investigate risk factors associated with right paraesophageal lymph node (RPELN) metastasis in patients with papillary thyroid carcinoma (PTC) and to determine the indications for right lymph node dissection. METHODS: Clinicopathologic data from 829 patients (104 men and 725 women) with PTC, operated on by the same thyroid surgery team at the First Affiliated Hospital of Harbin Medical University from January 2013 to May 2017, were analyzed. Overall, 309 patients underwent total thyroidectomy with bilateral lymph node dissection, 488 underwent right thyroid lobe and isthmic resection with right central compartment lymph node dissection, and 32 underwent near-total thyroidectomy (ipsilateral thyroid lobectomy with contralateral near-total lobectomy) with bilateral lymph node dissection...
March 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29517693/the-anteroposterior-diameter-of-nodules-in-the-risk-assessment-of-papillary-thyroid-microcarcinoma
#5
Kun Huang, Ningning Gao, Qixi Zhai, Donglin Bian, Difei Wang, Xuemei Wang
This study investigates the application of ultrasound, especially the anteroposterior diameter of nodules in the malignancy and metastasis risk assessment of papillary thyroid microcarcinoma through a retrospective analysis of 500 cases of thyroid nodule ultrasonography.We selected 500 patients with thyroid nodules (maximum nodule diameter ≤2.0 cm) that had been diagnosed clinically and graded TI-RADS 4c by ultrasonography and surgically treated. Among these, there were 258 cases of pathologically diagnosed papillary thyroid microcarcinoma, 72 cases of nodular goiter or adenoma, 137 cases of papillary thyroid carcinoma, 28 cases of acinar cell carcinoma, and 5 cases of undifferentiated carcinoma...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29516919/a-study-of-clinicopathological-characteristics-of-thyroid-carcinoma-at-a-tertiary-care-center
#6
Ankit A Shah, Preeti P Jain, Anjaney S Dubey, Ghanish N Panjwani, Hiral A Shah
Context: To share clinicopathological data of thyroid carcinoma from a high volume Tertiary Care Centre in East India. Aim: To share the epidemiology and clinicopathological presentation of thyroid cancer at a high volume Tertiary Care Center in East India. Settings and Design: Retrospective observational study. Subjects and Methods: Forty-two consecutive patients of thyroid neoplasm diagnosed by fine needle aspiration cytology (FNAC) and primarily underwent surgical treatment from July 2005 to June 2012 were included...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29509799/application-of-metabolomics-in-prediction-of-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#7
Ji Won Seo, Kyunghwa Han, Jandee Lee, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Hyeon-Man Baek, Jin Young Kwak
PURPOSE: The aim of this study was to find useful metabolites to predict lymph node (LN) metastasis in patients with papillary thyroid cancer (PTC) through a metabolomics approach and investigate the potential role of metabolites as a novel prognostic marker. MATERIALS AND METHODS: Fifty-two consecutive patients (median age: 41.5 years, range 15-74 years) were enrolled who underwent total thyroidectomy and central LN dissection with or without lateral LN dissection in Severance Hospital between October 2013 and July 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29488066/prophylactic-central-neck-dissection-for-papillary-thyroid-carcinoma-with-clinically-uninvolved-central-neck-lymph-nodes-a-systematic-review-and-meta-analysis
#8
Lawrence Chen, Yi-Hsiu Wu, Chia-Hwa Lee, Hsin-An Chen, El-Wui Loh, Ka-Wai Tam
BACKGROUND: Central neck dissection and total thyroidectomy are standard treatments for patients with papillary thyroid carcinoma (PTC) with clinically involved central nodes. However, prophylactic central neck dissection (pCND) in patients with clinically uninvolved cN0 has been beneficial in some studies but ineffective in others. We conducted a meta-analysis to evaluate the efficacy and safety of pCND in patients with central neck lymph nodes cN0 PTC. METHODS: The PubMed, EMBASE, Cochrane Library, and Scopus databases and the ClinicalTrials...
February 27, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29483425/-a-case-of-sj%C3%A3-gren-s-syndrome-associated-with-thyroid-cancer
#9
Katsuhisa Enomoto, Kenichi Sakurai
A 42-year-old woman who had a history of Sjögren's syndrome was admitted to our hospital because of a mass lesion in the left cervical region. A hard tumor in the left lobe and a smaller mass in the central area was detected by ultrasonography and computed tomography. Subtotal thyroidectomy with lymph node dissection was performed. The central mass was minimal thyroid carcinoma. The minimal thyroid carcinoma was discovered accidentally during therapy for Sjögren's syndrome. Because the symptoms decreased, surgery of the thyroid carcinoma could be performed...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29481991/the-role-of-two-tumor-foci-for-predicting-central-lymph-node-metastasis-in-papillary-thyroid-carcinoma-a-meta-analysis
#10
REVIEW
Jianhua Feng, Xiaoxiong Gan, Fei Shen, Wensong Cai, Bo Xu
BACKGROUND AND OBJECTIVE: Two tumor foci are the most common in multifocal papillary thyroid carcinoma, but whether they should be regarded as the indicator of central lymph node metastasis remains unclear. To investigate the role of two tumor foci for predicting central lymph node metastasis, we performed a meta-analysis of published studies. METHODS: We performed a systematic literature search of PubMed, Embase and Web of Science prior to September 29, 2017. The relevant articles were examined and the eligible studies were included to assess the metastatic risk of central lymph node in papillary thyroid carcinoma with one, two and more than two (>2) tumor foci...
February 23, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29462007/risk-factors-for-recurrence-after-treatment-of-n1b-papillary-thyroid-carcinoma
#11
Sang Hun Lee, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: To examine risk factors for posttreatment recurrence in papillary thyroid carcinoma (PTC) patients with initial presentation of lateral neck metastasis (N1b). SUMMARY OF BACKGROUND DATA: N1b PTC recurs after definitive treatment. METHODS: Study subjects were 437 consecutive PTC patients who underwent total thyroidectomy and therapeutic neck dissection of central and lateral compartments and postoperative radioactive iodine ablation therapy...
February 16, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29439716/risk-factors-of-lateral-lymph-node-metastasis-in-cn0-papillary-thyroid-carcinoma
#12
Daixing Hu, Jing Zhou, Wei He, Jie Peng, Yijia Cao, Haoyu Ren, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Xinliang Su
BACKGROUND: Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. METHODS: We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection...
February 13, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29438531/characteristics-of-follicular-variant-papillary-thyroid-carcinoma-in-a-pediatric-cohort
#13
S L Samuels, L F Surrey, C P Hawkes, M Amberge, S Mostoufi-Moab, J E Langer, N S Adzick, K Kazahaya, T Bhatti, Z Baloch, V A LiVolsi, A J Bauer
Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease. Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort. Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015...
February 8, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29429179/-evaluation-of-central-lymph-node-dissection-for-papillary-thyroid-carcinoma-in-cn0-t1-t2
#14
S Y Zhao, Y H Ma, Z Yin, X X Zhan, R C Cheng, J Qian
Objective: To evaluate the application of the central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) in cN0 T1/T2. Methods: Retrospective analysis of 532 cases with PTC in cN0 T1/T2 who underwent CLND between October 2014 and September 2016 in the Department of Thyroid Surgery, the First Affiliated Hospital of the Kunming Medical University. The incidence of central lymph node (CLN) metastasis and risk factors were analyzed. Results: CLN metastasis rates: 41.2% (42/102) in males vs 34.9% (150/430) in females, P =0...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29416604/cunr-scoring-system-for-the-prediction-of-lateral-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#15
Jianyong Lei, Gengpeng Li, Zhihui Li, R X Rong, Jingqiang Zhu
Objective: Our present study aimed to evaluate and compare the number and rate of central lymph node metastases (LNMs) for the prediction of lateral LNM (LLNM) in papillary thyroid carcinoma (PTC) and to develop a scoring system. Results: Capsule invasion, tumor location in the upper portion of the thyroid, an ipsilateral central compartment LNM number ≥3, and an ipsilateral central compartment LNM rate of ≥56% were identified as significant independent predictors of ipsilateral lateral LNM in PTC...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29398031/does-the-number-of-parathyroid-glands-autotransplanted-affect-the-incidence-of-hypoparathyroidism-and-recovery-of-parathyroid-function
#16
Anping Su, Yanping Gong, Wenshuang Wu, Rixiang Gong, Zhihui Li, Jingqiang Zhu
BACKGROUND: The relationship between the number of parathyroid glands autotransplanted and hypoparathyroidism as well as recovery of parathyroid function is not understood fully. The aim was to ascertain whether the number of autotransplanted glands affected the incidence of hypoparathyroidism and recovery of parathyroid function in long-term follow-up after thyroidectomy. METHODS: A retrospective cohort study included all patients with papillary thyroid carcinoma who underwent first-time total thyroidectomy with central neck dissection between June 2012 and June 2015...
February 2, 2018: Surgery
https://www.readbyqxmd.com/read/29397264/optimizing-treatment-for-children-and-adolescents-with-papillary-thyroid-carcinoma-in-post-chernobyl-exposed-region-the-roles-of-lymph-node-dissections-in-the-central-and-lateral-neck-compartments
#17
Mikhail Fridman, Olga Krasko, Alfred King-Yin Lam
There is lack of data to predict lymph node metastases in pediatric thyroid cancer. The aims are to study (1) the factors affecting the lymph node metastases in children and adolescence with papillary thyroid carcinoma in region exposed to radiation and (2) to evaluate the predictive significance of these factors for lateral compartment lymphadenectomy. Five hundred and nine patients with papillary thyroid carcinoma underwent total thyroidectomy and lymph nodes resection (central and lateral compartments of the neck) surgery during the period of 1991-2010 in Belarus were recruited...
January 9, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29383423/cervical-lymph-node-metastases-of-papillary-thyroid-carcinoma-in-the-central-and-lateral-compartments-in-children-and-adolescents-predictive-factors
#18
C Spinelli, F Tognetti, S Strambi, R Morganti, M Massimino, P Collini
PROBLEM STATEMENT: The aim of our study was to identify predictive factors for lymph node metastases (LNM) in children and adolescents with papillary thyroid carcinoma (PTC) and their impact on survival. METHODS: The authors conducted an Italian multicentric retrospective analysis on 132 pediatric patients (0-18 years old) affected by PTC between 2000 and 2014. The investigated variables were demographic characteristics of the patients, clinicopathological features of PTCs, and persistence/recurrence of disease...
January 30, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29372373/excellent-prognosis-of-central-lymph-node-recurrence-free-survival-for-cn0m0-papillary-thyroid-carcinoma-patients-who-underwent-routine-prophylactic-central-node-dissection
#19
Yasuhiro Ito, Akira Miyauchi, Hiroo Masuoka, Mitsuhiro Fukushima, Minoru Kihara, Akihiro Miya
INTRODUCTION: In Japan, prophylactic central node dissection (p-CND) for papillary thyroid carcinoma (PTC) has been routinely performed in many institutions, including ours (Kuma Hospital, Japan). We evaluated the recurrence to a central lymph node in patients with cN0M0 PTC who underwent routine p-CND. MATERIALS AND METHODS: We enrolled 4301 patients with cN0M0 PTC who underwent an initial surgery between 1987 and 2005 (median age 51 years). The postoperative follow-up periods ranged from 4 to 362 months (median 164 months)...
January 25, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29361659/associations-between-bethesda-categories-and-tumor-characteristics-of-conventional-papillary-thyroid-carcinoma
#20
Vivian Youngjean Park, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
Purpose: The aim of this study was to investigate the associations of Bethesda categories III, V, and VI with the clinical and pathological features of thyroid nodules surgically confirmed as conventional papillary thyroid carcinomas (PTCs). Methods: We analyzed 1,990 consecutive patients diagnosed with conventional PTC at surgery with preoperative Bethesda categories III, V, or VI. We determined the odds ratio (ORs) of the clinical and pathological variables associated with categories III and V, using category VI as the reference...
November 22, 2017: Ultrasonography
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