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central lymph node thyroid carcinoma

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https://www.readbyqxmd.com/read/28214213/the-relationship-between-brafv600e-nf-%C3%AE%C2%BAb-and-tgab-expression-in-papillary-thyroid-carcinoma
#1
Wei Li, Hui Ming, Danyang Sun, Wei Li, Dan Wang, Guizhi Zhang, Jian Tan
PURPOSE: The aim of this study was to investigate the potential link between thyroglobulin antibody (TgAb) titers and papillary thyroid carcinoma (PTC) aggressiveness. MATERIALS AND METHODS: This retrospective study included 122 patients who had undergone total thyroidectomy and neck central area lymph dissection followed by radioactive iodine (RAI) ablation for PTC between July 2012 and July 2014. The parameters included clinical characteristics of PTC, TgAb levels and tumor histopathological characteristics...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28166075/clinico-histopathological-survey-of-head-and-neck-cancer-at-tertiary-health-care-centre-dhulikhel-hospital
#2
S Dixit, C Upadhyaya, M Humagain, R Srii, V Marla
Background Head and neck is one of the most prevalent site for cancers along with lungs, cervix, breast and stomach. Hospital based cancer registries required for effective evaluation of diagnosis and management of cancer is inadequate in Nepal. Cancer registry system established by WHO is acquired by seven major hospitals in our country. However, data from tertiary health care centres like ours remain undocumented. Objective The objective of this study is to perform retrospective analysis of clinicohistopathological types of head and neck lesions which were eventually diagnosed as cancer in Dhulikel Hospital, a tertiary health care centre of Central East Nepal...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28160142/patterns-predictive-factors-and-prognostic-impact-of-contralateral-lateral-lymph-node-metastasis-in-n1b-papillary-thyroid-carcinoma
#3
Seo Ki Kim, Inhye Park, Nayoon Hur, Musaed Rayzah, Jun Ho Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
BACKGROUND: Although the incidence among patients with bilateral lateral lymph node metastasis (LLNM) in N1b papillary thyroid carcinoma (PTC) is reported to be as high as 40%, only a few reports have addressed the characteristics of contralateral LLNM. Therefore, this study aimed to investigate the characteristics of patients with contralateral LLNM in N1b PTC. METHODS: This study retrospectively reviewed 834 patients with N1b PTC who underwent modified radical neck dissection between January 1997 and June 2015...
February 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28149805/radioguided-sentinel-lymph-node-biopsy-in-patients-with-papillary-thyroid-carcinoma
#4
Mattia Portinari, Paolo Carcoforo
BACKGROUND: The ATA guidelines do not recommend prophylactic central compartment neck dissection in patients with T1-T2 papillary thyroid carcinoma (PTC) with no clinical evidence of lymph node metastasis, however patients' staging is recommended. Lymph node metastasis may be present also in small PTC, but preoperative ultrasound identifies suspicious cervical lymphadenopathy in 20-30% of patients. The role of sentinel lymph node biopsy (SLNB) remain open to debate. It has been shown that the identification rate of SLN in PTC patients is improved using a radiotracer compared to a dye technique...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28104029/-next-generation-sequencing-technology-for-susceptible-gene-screening-in-familial-non-medullary-thyroid-carcinoma
#5
L Dong, Y Yu, J P Yu, W J Hao, X Q Zheng, Y N Cheng, L Han, J Z Zhao, M Gao
Objective: To screen genes related to familial non-medullary thyroid carcinoma (FNMTC) using next-generation sequencing (NGS). Methods: A panel of NGS was designed and sequencing was performed for DNA samples extracted from peripheral blood leukocytes of FNMTC patients and sporadic non-medullary thyroid carcinoma (SNMTC) cases, respectively, and gene mutations were screened. In addition, the clinicopathological characteristics, including tumor size, extension of surgery, lymph node metastasis and extra-thyroidal extension, were compared between patients with or without mutations...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28094086/differentiated-and-medullary-thyroid-cancer-surgical-management-of-cervical-lymph-nodes
#6
P Asimakopoulos, I J Nixon, A R Shaha
Thyroid cancer metastasises to the central and lateral compartments of the neck frequently and early. The impact of nodal metastases on outcome is affected by the histological subtype of the primary tumour and the patient's age, as well as the size, number and location of those metastases. The impact of extranodal extension has recently been highlighted as an important prognosticating factor. Although clinically evident nodal disease in the lateral neck compartments has a significant impact on both survival and recurrence, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome...
January 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28050728/the-advantages-of-extended-subplatysmal-dissection-in-thyroid-surgery-the-mobile-window-technique
#7
Tina Runge, Roman Inglin, Philipp Riss, Andreas Selberherr, Reto M Kaderli, Daniel Candinas, Christian A Seiler
PURPOSE: Minimal access thyroidectomy, using various techniques, is widely known, but respective data on thyroidectomy for thyroid cancer with lymphadenectomy is scarce. The present study aims to evaluate the feasability of extended subplatysmal dissection in combination with a small incision ("mobile window" technique). METHODS: A retrospective study was performed analysing data from 93 patients. All patients suffered from thyroid carcinoma and underwent (total) thyroidectomy, bilateral cervico-central (levels VI and VII) and functional lateral neck dissection (levels II to V) on the side of the malignancy...
January 3, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28041636/a-comparative-study-of-the-surgical-outcomes-between-video-assisted-and-open-lateral-neck-dissection-for-papillary-thyroid-carcinoma-with-lateral-neck-lymph-node-metastases
#8
Deguang Zhang, Lei Xie, Gaofei He, Liang Fang, Yuwen Miao, Zhezhe Wang, Li Gao
PURPOSE: Video-assisted lateral neck dissection (VALND) for papillary thyroid carcinoma (PTC) with lateral neck lymph node metastases (LNM) has been described previously, however, the advantages and drawbacks of VALND have not been demonstrated in previous studies. The aim of this study was to compare the surgical outcomes of video-assisted and open lateral neck dissection for PTC with lateral neck LNM. MATERIALS AND METHODS: Between May 2013 and November 2014, 92 consecutive patients with PTC and lateral neck lymph node metastases underwent total thyroidectomy with central compartment neck dissection and unilateral lateral neck dissection...
July 27, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27989915/application-of-carbon-nanoparticles-accelerates-the-rapid-recovery-of-parathyroid-function-during-thyroid-carcinoma-surgery-with-central-lymph-node-dissection-a-retrospective-cohort-study
#9
Bin Wang, Zhi-Peng Du, Nian-Cun Qiu, Miao-E Liu, Sheng Liu, Dao-Zhen Jiang, Wei Zhang, Ming Qiu
BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the efficacy of carbon nanoparticles in identifying lymph nodes and promoting parathyroid gland function recovery after thyroid carcinoma surgery along with central lymph node dissection. METHODS: A total of 231 patients who underwent thyroid carcinoma surgery combined with central lymph node dissection were divided into two groups: the CN group (intraoperative carbon nanoparticles injections) and the control group (no injection)...
October 27, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27900764/a-novel-thyroid-cancer-nodal-map-classification-system-to-facilitate-nodal-localization-and-surgical-management-the-a-to-d-map
#10
Marybeth Cunnane, Natalia Kyriazidis, Dipti Kamani, Amy F Juliano, Hillary R Kelly, Hugh D Curtin, Samuel R Barber, Gregory W Randolph
OBJECTIVES/HYPOTHESIS: To evaluate the effectiveness, reproducibility, and usability of our proposed nodal nomenclature and classification system employed for several years in our high-volume thyroid cancer unit, for the adequate localization and mapping of lymph nodes in thyroid cancer patients with extensive nodal disease. STUDY DESIGN: Retrospective review. METHODS: Thirty-three thyroid cancer patients with extensive nodal disease treated from January 2004 to May 2013 were included in our study...
November 30, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27859312/nomogram-for-predicting-central-node-metastasis-in-papillary-thyroid-carcinoma
#11
Seo Ki Kim, Young Jun Chai, Inhye Park, Jung-Woo Woo, Jun Ho Lee, Kyu Eun Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
BACKGROUND: There was a difficulty for detecting Central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) patients. Therefore, the purpose of this study was to design a nomogram for predicting CLNM. METHODS: A total of 10,763 PTC patients who underwent total thyroidectomy with central neck dissection (CND) in Samsung Medical Center were randomly assigned to the training set (n = 7,535) and to the internal validation set (n = 3,228). And, a total of 2,514 PTC patients who underwent total thyroidectomy with CND at Seoul National University Hospital were assigned to the external validation set...
November 18, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27833882/adult-thyroglossal-duct-carcinoma-of-thyroid-epithelial-origin-a-retrospective-observational-study
#12
Rahim Akram, Joseph J Wiltshire, Jonathan Wadsley, Sabapathy P Balasubramanian
Thyroglossal duct or cyst carcinoma (TGDCCa) is uncommon. Current treatments follow those of thyroid cancer but controversy exists over the extent of thyroid and lymph node surgery. Our aim was to study the presentation, treatment strategies and clinical outcomes in patients presenting with TGDCCa. Of 637 patients diagnosed with thyroid cancer over 15-years, 4 patients (0.6 %) with TGDCCa were identified. Two patients were diagnosed outside this time period. Details of demographics, presentation, diagnosis, management and outcomes of all 6 patients were reviewed...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27806783/-clinicopathological-features-of-thyroid-papillary-microcarcinoma-of-which-the-maximum-diameter-is-less-than-5-mm-a-series-of-487-cases
#13
C Chen, H Z Chen, C H Lyu, S Xue, N K Yu, X Chen
Objective: To analyze the clinical and pathological features of papillary thyroid microcarcinoma(PTMC) of which the maximum diameter is less than 5 mm. Methods: Clinical data of 487 PTMC (≤5 mm) patients who underwent primary surgery by the same team of doctors between March 2013 to March 2016 at Department of Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University were analyzed retrospectively. Female patients accounted for 77.4%(377/487). The age ranged from 22 to 80 years, with an average of (46±11) years...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27806782/-modified-minimally-invasive-video-assisted-lateral-neck-dissection-for-papillary-thyroid-carcinoma-a-series-of-130-cases
#14
D G Zhang, L Gao, L Xie, G F He, L Fang, J Chen, Y W Miao, Z Z Wang
Objective: To discuss the feasibility, safety and oncologic completeness of modified minimally invasive video-assisted lateral neck dissection (MIVALND) for papillary thyroid carcinoma. Methods: Data of 130 patients from Department of Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical School, Zhejiang University undergoing MIVALND from January 2013 to September 2015 were reviewed retrospectively. There were 31 male and 99 female patients with the mean age of (39±11) years. The thyroidectomy and central compartment dissection were performed under a direct visual field or video-assisted (VA) approach, lateral neck dissection was performed via the VA approach...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27775804/the-impact-of-the-multifocality-and-subtypes-of-papillary-thyroid-carcinoma-on-central-compartment-lymph-node-metastasis
#15
L Soylu, O U Aydin, S Ozbas, B Bilezikci, S Ilgan, A Gursoy, S Kocak
OBJECTIVE: Papillary thyroid carcinoma (PTC) may often appear as multifocal disease. Few studies demonstrated a higher rate of central compartment lymph node metastasis (CCLNM) in multifocal PTC patients. Therefore, the effect of different histological subtypes of multifocal PTC on CCLNM is another subject for further examination. The aim of the present study is to evaluate the rate of central lymph node positivity in multifocal PTC as compared to unifocal disease, and to identify the role of different histologic subtypes of PTC on central neck lymph node positivity...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27774578/propensity-score-matched-analysis-of-robotic-versus-endoscopic-bilateral-axillo-breast-approach-baba-thyroidectomy-in-papillary-thyroid-carcinoma
#16
Seo Ki Kim, Jung-Woo Woo, Inhye Park, Jun Ho Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
PURPOSE: The da Vinci surgical robot system was developed to overcome the weaknesses of endoscopic surgery. However, whether robotic surgery is superior to endoscopic surgery remains uncertain. Therefore, the purpose of this study was to compare the surgical and oncologic outcomes between endoscopic and robotic thyroidectomy using bilateral axillo-breast approach (BABA). METHODS: Between January 2008 and June 2015, papillary thyroid carcinoma patients who underwent thyroidectomy with central neck dissection using endoscopic (n = 480) or robotic (n = 705) BABA were primarily reviewed...
October 24, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27750022/predicting-factors-for-bilaterality-in-papillary-thyroid-carcinoma-with-tumor-size-4%C3%A2-cm
#17
Seo Ki Kim, Inhye Park, Jung-Woo Woo, Jun Ho Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
BACKGROUND: In the 2015 American Thyroid Association guidelines, either lobectomy or total thyroidectomy was recommended for thyroid cancer <4 cm without extrathyroidal extension (ETE) and lymph node (LN) metastasis. Therefore, the purpose of this study was to investigate factors predictive of bilaterality in papillary thyroid carcinoma (PTC) patients with tumor size <4 cm. METHODS: This study retrospectively reviewed 3296 conventional PTC patients who underwent total thyroidectomy with central neck dissection and/or lateral neck dissection between January 2008 and June 2015...
February 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27743717/inadvertent-parathyroidectomy-during-total-thyroidectomy-and-central-neck-dissection-for-papillary-thyroid-carcinoma
#18
Antonio Sitges-Serra, Lander Gallego-Otaegui, Sergio Suárez, Leyre Lorente-Poch, Assumpta Munné, Juan J Sancho
BACKGROUND: The main drawback of central neck lymph node dissection is postoperative parathyroid failure. Little information is available concerning inadvertent resection of the parathyroid glands in this setting and its relationship to postoperative hypoparathyroidism. Our aim was to determine the prevalence of inadvertent parathyroidectomy during total thyroidectomy and central neck dissection for papillary thyroid cancer and its impact on short-and long-term parathyroid function. METHODS: This was a prospective observational study of consecutive patients undergoing first-time total thyroidectomy with a central neck dissection for papillary carcinoma >10 mm...
October 13, 2016: Surgery
https://www.readbyqxmd.com/read/27738849/thyroglobulin-measurement-in-fine-needle-aspiration-improves-the-diagnosis-of-cervical-lymph-node-metastases-in-papillary-thyroid-carcinoma
#19
Zahraa Al-Hilli, Veljko Strajina, Travis J McKenzie, Geoffrey B Thompson, David R Farley, M Regina Castro, Alicia Algeciras-Schimnich, Melanie L Richards
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently associated with cervical lymph node metastases. Guidelines recommend performing ultrasound-guided fine-needle aspiration cytology (FNAC) for suspicious nodes to guide management. No specific recommendations are available for the use of FNA thyroglobulin assay (FNA-Tg). This study investigated the diagnostic value of performing FNAC and FNA-Tg. METHODS: Patient demographics, preoperative investigations, surgery, and lymph node pathology were collected for patients with PTC who underwent lateral neck lymphadenectomy and central compartment reexploration from January 2000 to July 2015...
March 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27737333/risk-factors-analyses-for-lateral-lymph-node-metastases-in-papillary-thyroid-carcinomas-a-retrospective-study-of-356-patients
#20
Xilin Nie, Zhuo Tan, MingHua Ge, LieHao Jiang, JiaFeng Wang, ChuanMing Zheng
Objective: The aim of this study was to investigate the incidence and risk factors for lateral lymph node metastasis (LLNM) in patients with papillary thyroid carcinoma (PTC). Subjects and methods: 356 patients diagnosed with PTC who underwent total thyroidectomy and central lymph node dissection and lateral lymph node dissection between January 2005 and December 2011 were enrolled. The relation between LLNM and clinicopathological features such as gender, age, tumor size, tumor spread, psammoma bodies, tumor multifocality, extrathyroidal extension (ETE), unilateral or bilateral disease, tumor primary location and central lymph node metastases (CLNM) was analyzed...
October 2016: Archives of Endocrinology and Metabolism
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