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central lymph node thyroid carcinoma

Aires Martins, Alvaro Gonçalves, Teresa Almeida, Alberto Midões
Carcinoembryonic antigen (CEA) is still the most widely used tumour marker for gastrointestinal cancer. CEA was originally thought to be a specific marker for colorectal cancer, but it turned out to be a non-specific marker for further studies. CEA levels can be elevated in breast, lung and liver cancers, among others, including medullary thyroid cancer. The authors report a case of a 73-year-old woman who had a right hemicolectomy for an ascending colon adenocarcinoma and showed a persistent elevation in the CEA marker during follow-up...
June 11, 2018: BMJ Case Reports
Chih-Yi Liu, Shih-Hung Huang
BACKGROUND: Lymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors. Based on the limited number of case reports that exist, the association of Epstein-Barr virus (EBV) with primary thyroid LELCs seems inconsistent. CASE PRESENTATION: We present a confusing cytological case of lymphoepithelioma-like thyroid carcinoma with expression of EBV. The patient presented with a central neck mass and bilateral lymphadenopathy. Fine-needle aspiration cytology revealed three-dimensional and syncytial fragments of epithelioid cells accompanied by small lymphocytes...
June 9, 2018: Diagnostic Pathology
Sabin Filimon, Richard J Payne, Martin J Black, Michael P Hier, Alex M Mlynarek, Veronique-Isabelle Forest, Michael Tamilia
OBJECTIVE: Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C-cells with the potential for aggressive behavior. The extent of lymph node (LN) dissection at the time of surgery is controversial, with different schools of thought prevailing. Some systematically perform LN dissections, whereas others base their decision on radiologic evidence of disease and some with the assistance of pre-operative calcitonin (CT) levels. METHODS: We retrospectively assessed the correlation between pre-operative CT levels and clinico-pathologic factors among 42 patients with MTC between 1994 and 2015...
May 2018: Endocrine Practice
Yunjun Wang, Qing Guan, Jun Xiang
INTRODUCTION: The status of central lymph node metastasis (CLNM) is crucial to determining the surgical strategies for papillary thyroid micro carcinoma (PTMC). The objective of the study was to establish a nomogram to predict the possibility of CLNM in PTMC patients. METHODS: A total of 8668 PTMC patients who underwent total thyroidectomy or lobectomy with central lymph node dissection (CLND) from 2006 to 2016 were retrospectively retrieved. Univariate and multivariate analysis were performed to examine risk factors associated with CLNM...
May 24, 2018: International Journal of Surgery
A B Zhang, L F Liu, C Lu, Y Y Ma, Y B Dong, X Y Ge
Objective: To investigate the risk factors of central neck lymph node metastasis (CNLNM) in cN0 papillary thyroid carcinoma. Method: Retrospective analysis of 114 patients with papillary thyroid carcinoma in stage of cN0 who underwent primary treatment. Collected the clinical and pathological data, used the univariate and multivariate analysis to investigate the risk factors of central neck lymph node metastasis and high volume central neck lymph node metastasis. Result: In the univariate analysis, age (48...
August 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
S Zhang, X H Jiang
Objective: To investigate the clinical characteristics of the risk factors of papillary thyroid carcinoma in different ages of young patients (<45y)associated with carbon nanoparticles. Method: A retrospective statistics and analysis of 183 patients who were diagnosed and treated; carbon nanoparticles were injected into the thyroid during operation and at last the conventional pathological diagnosis were papillary thyroid carcinoma of all patients; to analysis the gender, tumor size, capsular invasion, lymph node metastasis, multifocality and other risk factors between the <25y and 25-<5y patients...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
J Zhang, K Yao, K L Li
Objective: To compare the effectiveness and safety between minimally invasive video-assisted thyroidectomy (MIVAT) and conventional thyroidectomy (CT) in the treatment of papillary thyroid carcinoma without lymph node metastasis, providing clinicians using video-assisted way to treat thyroid papillary carcinoma with a more reasonable basis. Method: According to the including and excluding criterion,we searched the published articles which compare the effectiveness of MIVAT and CT curing PTC in randomized controlled clinical trials...
September 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Yi-Jun Lyu, Fang Shen, Hai Zhang, Gao-Xiang Chen
Objective To summarize our experiences in using an elastic traction, space-making technique for endoscopic thyroidectomy via breast approach in the treatment of early-stage differentiated papillary thyroid carcinoma. Methods A retrospective analysis was performed on patients who underwent endoscopic thyroidectomy via breast approach for thyroid carcinoma in our department. We used our self-developed "mini elastic traction space-maker" in a group of 34 patients; another 45 patients who underwent the procedure with the conventional CO2 insufflation method were enlisted as the control group...
January 1, 2018: Journal of International Medical Research
Marco Raffaelli, Carmela De Crea, Luca Sessa, Guido Fadda, Celestino Pio Lombardi, Rocco Bellantone
PURPOSE: Histological variants of papillary thyroid carcinoma (PTC) have been advocated as possible risk factors for central neck nodal metastases (CNM). A lower incidence of CNM in follicular variant of papillary thyroid carcinoma (fvPTC) when compared with classic PTC (cPTC) has been observed. We aimed to compare risk factors for CNM in patients with fvPTC and cPTC. METHODS: The medical records of 1737 patients with a diagnosis of cPTC or fvPTC were reviewed. Demographic, clinical and pathological findings were prospectively registered...
May 16, 2018: Endocrine
Sazan Rasul, Sabrina Hartenbach, Katharina Rebhan, Adelina Göllner, Georgios Karanikas, Marius Mayerhoefer, Peter Mazal, Marcus Hacker, Markus Hartenbach
PURPOSE: Medullary thyroid carcinoma (MTC) is characterized by a high rate of metastasis. In this study we evaluated the ability of [18 F]DOPA PET/ceCT to stage MTC in patients with suspicious thyroid nodules and pathologically elevated serum calcitonin (Ctn) levels prior to total thyroidectomy and lymph node (LN) dissection. METHODS: A group of 32 patients with sonographically suspicious thyroid nodules and pathologically elevated basal Ctn (bCtn) and stimulated Ctn (sCtn) levels underwent DOPA PET/ceCT prior to surgery...
May 15, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Haoyu Ren, Yifan Shen, Daixing Hu, Wei He, Jing Zhou, Yijia Cao, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Yuhong Zhang, Xinliang Su
Background: Mutations of BRAF V600E and TERT promoters are associated with thyroid cancer development. This study further investigated association of these mutations with clinicopathological characteristics from patients with papillary thyroid carcinoma (PTC). Methods: Tumor tissues from 342 PTC patients were obtained for DNA extraction and polymerase chain reaction amplification to detect the BRAF V600E mutation using amplification-refractory mutation system-polymerase chain reaction...
2018: Cancer Management and Research
J Wang, S Y Wang
The cervical lymph node metastasis is a risk factor for the high recurrence rate and low survival rate in patients with thyroid carcinoma (especially for age ≥45 years old), which is the most common head and neck carcinoma. The neck lymphatic metastasis, mostly occurring in the central neck compare, is diagnosed among 20%-90% of patients with differentiated thyroid carcinoma. To definite the anatomic boundaries of the central lymph nodes and their subgroups is significantly important for thyroid carcinoma, such as the determination of surgical extent, the evaluation of prognosis and the choice of different treatment strategies...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Dilip K Das, Smiley A George, Tareq Mohammad, Bency John, Sara S George, Abdulla I Behbehani
Carcinoma associated with thyroglossal duct cyst (TDC) is extremely rare and when it occurs it is invariably papillary carcinoma. A 36-year-old man presented with a midline swelling in the upper part of neck, which was a cystic lesion with multiple septae in ultrasonogram, indicating a thyroglossal duct cyst. The CT scan findings also corroborated the ultrasound report. Fine needle aspiration (FNA) smears showed hemosiderin laden cyst macrophages and occasional papillary cluster of neoplastic cells with central psammoma body and rare intranuclear cytoplasmic inclusions...
May 8, 2018: Diagnostic Cytopathology
Sinisa Maksimovic, Branislava Jakovljevic, Zdenka Gojkovic
Background: The purpose of this study is to establish whether the lymph node metastases of the papillary thyroid carcinoma are a significant factor in recurrence of the disease by analyzing the time until recurrence of the disease and frequency of recurrence of the disease. Methods: From 1 January 1995 until 30 June 2017, 102 patients were treated at the Public Health Institute Hospital "Sveti Vracevi" in Bijeljina for PTC. In all patients, surgery of the thyroid gland and/or lymph nodes of the neck was performed...
April 2018: Medical Archives
Young Woo Chang, Hye Yoon Lee, Hwan Soo Kim, Hoon Yub Kim, Jae Bok Lee, Gil Soo Son
Purpose: The incidence of papillary thyroid carcinoma (PTC) arising from the isthmus is low; however, these tumors have aggressive clinical and pathological features. Moreover, the existing guidelines regarding the extent of surgery for this type of tumor are unclear. Methods: This study enrolled 282 patients who underwent total thyroidectomy with bilateral central lymph node dissection. The patients were divided into 2 groups based on the location of the median line of the PTC...
May 2018: Annals of Surgical Treatment and Research
Wen Liu, Ruochuan Cheng, Yunhai Ma, Dan Wang, Yanjun Su, Chang Diao, Jianming Zhang, Jun Qian, Jin Liu
Early preoperative diagnosis of central lymph node metastasis (CNM) is crucial to improve survival rates among patients with papillary thyroid carcinoma (PTC). Here, we analyzed clinical data from 2862 PTC patients and developed a scoring system using multivariable logistic regression and testified by the validation group. The predictive diagnostic effectiveness of the scoring system was evaluated based on consistency, discrimination ability, and accuracy. The scoring system considered seven variables: gender, age, tumor size, microcalcification, resistance index >0...
May 3, 2018: Scientific Reports
Tong Tang, Jia Li, Lu Zheng, Lei Zhang, Jianing Shi
OBJECTIVE: The aim of this study was to explore the risk factors that were associated with central lymph node metastases (CLNM) in papillary thyroid carcinoma (PTC) patients. METHODS: A total of 180 patients with PTC who underwent surgery in our hospital between January 2014 and December 2016 were identified retrospectively. The relationship between clinicopathological factors and CLNM were analyzed by univariate and multivariate logistic regression. RESULTS: The incidence of CLNM was 67...
April 30, 2018: International Journal of Surgery
Yushi Sun, Hongjun Lv, Shaoqiang Zhang, Yanxia Bai, Bingyin Shi
Our aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; P = 0.001), age (≥45 y; P < 0.001), tumor size (>1 cm; P < 0.001), and multifocality ( P = 0.004) were independent predictive factors of CLNM in PTC patients. Patients were divided into male group ( n = 152) and female group ( n = 438)...
2018: International Journal of Endocrinology
Erik Folch, Colleen Keyes
Stents and tubes to maintain the patency of the airways are commonly used for malignant obstruction and are occasionally employed in benign disease. Malignant airway obstruction usually results from direct involvement of bronchogenic carcinoma, or by extension of carcinomas occurring in the esophagus or the thyroid. External compression from lymph nodes or metastatic disease from other organs can also cause central airway obstruction. Most malignant airway lesions are surgically inoperable due to advanced disease stage and require multimodality palliation, including stent placement...
March 2018: Annals of Cardiothoracic Surgery
Junko Akaishi, Tetsuo Kondo, Kiminori Sugino, Yuna Ogimi, Chie Masaki, Kiyomi Y Hames, Tomonori Yabuta, Chisato Tomoda, Akifumi Suzuki, Kenichi Matsuzu, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Ryohei Katoh, Koichi Ito
BACKGROUND: Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is rare; it may occur in cases of familial adenomatous polyposis (FAP) or be sporadic. To clarify the clinicopathological features of CMV-PTC, the medical records of these patients were investigated retrospectively. MATERIALS AND METHODS: Between 1979 and 2016, a total of 17,062 cases with PTC underwent initial surgery at Ito Hospital. Of these, 30 (0.2%) cases histologically diagnosed with CMV-PTC were reviewed...
April 25, 2018: World Journal of Surgery
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