So-Yon Lim, Jina Lee, Christa E Osuna, Pratik Vikhe, Dane R Schalk, Elsa Chen, Emily Fray, Mithra Kumar, Nancy Schultz-Darken, Eva Rakasz, Saverio Capuano, Ruby A Ladd, Hwi Min Gil, David T Evans, Emily K Jeng, Michael Seaman, Malcolm Martin, Christiaan Van Dorp, Alan S Perelson, Hing C Wong, Janet D Siliciano, Robert Siliciano, Jeffrey T Safrit, Douglas F Nixon, Patrick Soon-Shiong, Michel Nussenzweig, James B Whitney
The eradication of the viral reservoir represents the major obstacle to the development of a clinical cure for established HIV-1 infection. Here, we demonstrate that the administration of Anktiva (N-803) and broadly neutralizing antibodies (bNAbs) resulted in sustained viral control after discontinuation of antiretroviral therapy (ART) in SHIV-AD8-infected, ART-suppressed rhesus macaques. N-803+bNAbs treatment induced immune activation and transient viremia, but only limited reductions in the SHIV reservoir...
February 29, 2024: Science