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https://www.readbyqxmd.com/read/28719153/in-source-collision-induced-dissociation-is-cid-applications-issues-and-structure-elucidation-with-single-stage-mass-analyzers
#1
Jon F Parcher, Mei Wang, Amar G Chittiboyina, Ikhlas A Khan
A discussion of the definition, advantages and issues with the formation of ions in the transition region between an ESI source and the ion optics of a mass analyzer is presented. The various types of ions formed in the so-called in-source collision induced dissociation (IS-CID) process are illustrated. Applications of IS-CID with single-stage mass analyzers, such as structure elucidation and quantitation, are demonstrated. The discussion is illustrated by examples of the in-source fragmentation of ginkgolides, which are marker compounds found only in Ginkgo biloba...
July 18, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28718511/genome-wide-identification-of-genes-involved-in-the-potato-response-to-drought-indicates-functional-evolutionary-conservation-with-arabidopsis-plants
#2
M Pieczynski, A Wyrzykowska, K Milanowska, D Boguszewska-Mankowska, B Zagdanska, W Karlowski, A Jarmolowski, Z Szweykowska-Kulinska
Potato is one of the four most important food crop plants worldwide and is strongly affected by drought. The following two pairs of potato cultivars, which are related in ancestry but show different drought tolerances, were chosen for comparative gene expression studies: Gwiazda/Oberon and Tajfun/Owacja. Comparative RNA-seq analyses of gene expression differences in the transcriptomes obtained from drought-tolerant versus drought-sensitive plants during water shortage conditions were performed. The twenty-three top-ranking genes were selected, 22 of which are described here as novel potato drought-responsive genes...
July 17, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28715208/highly-stereoselective-synthesis-of-tetrasubstituted-acyclic-all-carbon-olefins-via-enol-tosylation-and-suzuki%C3%A2-miyaura-coupling
#3
Beryl X Li, Diane N Le, Kyle A Mack, Andrew McClory, Ngiap-Kie Lim, Theresa Cravillion, Scott Savage, Chong Han, David B Collum, Haiming Zhang, Francis Gosselin
A highly stereocontrolled synthesis of tetrasubstituted acyclic all-carbon olefins has been developed via a stereoselective enolization and tosylate formation, followed by a palladium-catalyzed Suzuki‒Miyaura cross-coupling of the tosylates and pinacol boronic esters in the presence of Pd(OAc)2/RuPhos catalytic system. Both the enol tosylation and Suzuki‒Miyaura coupling reactions tolerate an array of electronically and sterically diverse substituents and generate high yield and stereoselectivity of the olefin products...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28714949/aspartate-%C3%AE-hydroxylase-disrupts-mitochondrial-dna-stability-and-function-in-hepatocellular-carcinoma
#4
C Tang, Y Hou, H Wang, K Wang, H Xiang, X Wan, Y Xia, J Li, W Wei, S Xu, Z Lei, T M Pawlik, H Wang, M Wu, F Shen
The mechanism of aberrant mitochondrial genome and function in hepatocellular carcinoma (HCC) remains largely unknown. Our previous study demonstrated an increased expression of aspartate β-hydroxylase (ASPH) in HCC tissues, which was associated with tumor invasiveness and a worse prognosis. Currently, we unexpectedly observed the presence of ASPH in purified mitochondrial protein fraction. In addition, immunostaining of both exogenously and endogenously expressed ASPH showed a colocalization with mitochondrial biomarkers...
July 17, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28714569/seasonal-dynamics-of-the-tick-haemaphysalis-tibetensis-in-the-tibetan-plateau-china
#5
M Liu, T Li, Z J Yu, Z X Qiu, P Yan, Y Li, J Liu
The tick Haemaphysalis tibetensis (Acari: Ixodidae) Hoogstraal is an important arthropod vector widespread in the Qinghai-Tibet Plateau, and knowledge of its seasonal dynamics is still poor. The current study investigated the seasonal dynamics of the parasitic and non-parasitic H. tibetensis over a 2-year period from March 2014 to February 2016 in the Tibetan Plateau, China. During this timeframe, non-parasitic ticks were collected weekly by flag-dragging in grassland and shrubland areas, and parasitic ticks were removed weekly from selected sheep...
July 17, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28714091/habitual-diet-and-diet-quality-in-irritable-bowel-syndrome-a%C3%A2-case-control-study
#6
E F Tigchelaar, Z Mujagic, A Zhernakova, M A M Hesselink, S Meijboom, C W M Perenboom, A A M Masclee, C Wijmenga, E J M Feskens, D M A E Jonkers
BACKGROUND: Diet is considered to be a key factor in symptom generation in Irritable Bowel Syndrome (IBS) and patients tend to exclude food products from their diet in pursue of symptom relief, which may impair diet quality. METHODS: We evaluated habitual dietary intake in IBS patients with regard to nutrients and food products using an extensive food frequency questionnaire. One hundred ninety-four IBS patients were compared to 186 healthy controls using multiple logistic regression analysis...
July 17, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28711955/the-effect-of-early-feeding-practices-on-growth-indices-and-obesity-at-preschool-children-from-four-european-countries-and-uk-schoolchildren-and-adolescents
#7
George Moschonis, Blandine de Lauzon-Guillain, Louise Jones, Andreia Oliveira, Christina-Paulina Lambrinou, Louiza Damianidi, Sandrine Lioret, Pedro Moreira, Carla Lopes, Pauline Emmett, Marie Aline Charles, Yannis Manios
Not only healthy growth but also childhood obesity partly originate from early life. The current work aimed to examine the association of feeding practices during infancy with growth and adiposity indices in preschool children from four European countries and in UK schoolchildren and adolescents. Existing data from four European birth cohorts (ALSPAC-UK, EDEN-France, EuroPrevall-Greece and Generation XXI-Portugal) were used. Anthropometrics and body composition indices were collected. Parallel multivariate regression analyses were performed to examine the research hypothesis...
July 15, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28711211/advanced-tissue-characterization-and-texture-analysis-using-dual-energy-computed-tomography-horizons-and-emerging-applications
#8
REVIEW
Reza Forghani, Ashok Srinivasan, Behzad Forghani
In the last article of this issue, advanced analysis capabilities of DECT is reviewed, including spectral Hounsfield unit attenuation curves, virtual monochromatic images, material decomposition maps, tissue effective Z determination, and other advanced post-processing DECT tools, followed by different methods of analysis of the attenuation curves generated using DECT. The article concludes with exciting future horizons and potential applications, such as the use of the rich quantitative data in dual energy CT scans for texture or radiomic analysis and the use of machine learning methods for generation of prediction models using spectral data...
August 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28709366/correspondence-between-spanning-trees-and-the-ising-model-on-a-square-lattice
#9
G M Viswanathan
An important problem in statistical physics concerns the fascinating connections between partition functions of lattice models studied in equilibrium statistical mechanics on the one hand and graph theoretical enumeration problems on the other hand. We investigate the nature of the relationship between the number of spanning trees and the partition function of the Ising model on the square lattice. The spanning tree generating function T(z) gives the spanning tree constant when evaluated at z=1, while giving the lattice green function when differentiated...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708615/treatment-of-poultry-slaughterhouse-wastewater-using-a-static-granular-bed-reactor-sgbr-coupled-with-ultrafiltration-uf-membrane-system
#10
M Basitere, Z Rinquest, M Njoya, M S Sheldon, S K O Ntwampe
The South African poultry industry has grown exponentially in recent years due to an increased demand for their products. As a result, poultry plants consume large volumes of high quality water to ensure that hygienically safe poultry products are produced. Furthermore, poultry industries generate high strength wastewater, which can be treated successfully at low cost using anaerobic digesters. In this study, the performance of a bench-scale mesophilic static granular bed reactor (SGBR) containing fully anaerobic granules coupled with an ultrafiltration (UF) membrane system, as a post-treatment system, was investigated...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28708391/enantioselective-synthesis-of-anti-1-2-oxaborinan-3-enes-from-aldehydes-and-1-1-di-boryl-alk-3-enes-using-ruthenium-and-chiral-phosphoric-acid-catalysts
#11
Tomoya Miura, Junki Nakahashi, Wang Zhou, Yota Shiratori, Scott G Stewart, Masahiro Murakami
A cationic ruthenium(II) complex catalyzes double-bond transposition of 1,1-di(boryl)alk-3-enes to generate in situ 1,1-di(boryl)alk-2-enes, which then undergo chiral phosphoric acid-catalyzed allylation of aldehydes producing homoallylic alcohols with a (Z)-vinylboronate moiety. 1,2-Anti stereochemistry is installed in an enantioselective manner. The (Z)-geometry forged in the products allows their isolation in a form of 1,2-oxaborinan-3-enes, upon which further synthetic transformations are operated.
July 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28702255/diabetes-and-its-drivers-the-largest-epidemic-in-human-history
#12
EDITORIAL
Paul Z Zimmet
The "Diabesity" epidemic (obesity and type 2 diabetes) is likely to be the biggest epidemic in human history. Diabetes has been seriously underrated as a global public health issue and the world can no longer ignore "the rise and rise" of type 2 diabetes. Currently, most of the national and global diabetes estimates come from the IDF Atlas. These estimates have significant limitations from a public health perspective. It is apparent that the IDF have consistently underestimated the global burden. More reliable estimates of the future burden of diabetes are urgently needed...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/28700943/a-role-for-mitochondrial-translation-in-promotion-of-viability-in-k-ras-mutant-cells
#13
Timothy D Martin, Danielle R Cook, Mei Yuk Choi, Mamie Z Li, Kevin M Haigis, Stephen J Elledge
Activating mutations in the KRAS oncogene are highly prevalent in tumors, especially those of the colon, lung, and pancreas. To better understand the genetic dependencies that K-Ras mutant cells rely upon for their growth, we employed whole-genome CRISPR loss-of-function screens in two isogenic pairs of cell lines. Since loss of essential genes is uniformly toxic in CRISPR-based screens, we also developed a small hairpin RNA (shRNA) library targeting essential genes. These approaches uncovered a large set of proteins whose loss results in the selective reduction of K-Ras mutant cell growth...
July 11, 2017: Cell Reports
https://www.readbyqxmd.com/read/28700034/application-of-endoscopy-to-treat-mandibular-keratocystic-odontogenic-tumors
#14
Z Gao, Q W Ni, W Gao, Y P Liu, Q Zhang
The aim of this study was to evaluate the feasibility of endoscopy to remove keratocystic odontogenic tumors (KCOTs) with virtual 3D mandibular images. Fifteen patients (mean age, 40.27±14.58 years) who underwent endoscopic mandibular KCOT enucleation between May 2009 and October 2009 were included. Virtual 3D mandibular reconstructions derived from computed tomography (CT) imaging were generated for all patients. Recurrence and pathological fracture were evaluated as the primary outcome variables at 1 and 12 months after operation...
July 10, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28697990/avian-antibodies-igy-against-trypanosoma-cruzi-purification-and-characterization-studies
#15
Thirssa H Grando, Matheus D Baldissera, Mariângela F de Sá, Guilherme do Carmo, Bianca Carolina Z Porto, Gisele S V Aguirre, Maria Isabel de Azevedo, Francielli P K de Jesus, Janio M Santurio, Michele R Sagrillo, Lenita Moura Stefani, Silvia Gonzalez Monteiro
Trypanosoma cruzi is a flagellated protozoan belonging to the Trypanosomatidae family, the etiologic agent of Chagas disease. Currently, there is neither a licensed vaccine nor effective treatment, characterizing an unmet clinical need. The IgY refers to the egg yolk immunoglobulin (Y=yolk) and its production and use are subjects of many studies due to the diversity of its diagnostic and therapeutic applications. Several researchers have shown that the use of specific IgY may prevent and/or control infectious and parasitic diseases...
July 8, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28697406/efficacy-of-pharmacologic-closure-of-patent-ductus-arteriosus-in-small-for-gestational-age-extremely-preterm-infants
#16
Nansi S Boghossian, Barbara T Do, Edward F Bell, John M Dagle, Jane E Brumbaugh, Barbara J Stoll, Betty R Vohr, Abhik Das, Seetha Shankaran, Pablo J Sanchez, Myra H Wyckoff, M Bethany Ball
BACKGROUND: Optimal management of the patent ductus arteriosus (PDA) in preterm infants remains controversial. Therefore, studies identifying infants who are most likely to benefit from PDA treatment are needed. AIM: We sought to examine if significant intrauterine growth restriction, defined by birth weight z-score, reduces the efficacy of PDA closure with indomethacin or ibuprofen and thereby increases the need for surgical closure of PDA after pharmacologic treatment...
July 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/28696674/lasso-peptide-benenodin-1-is-a-thermally-actuated-1-rotaxane-switch
#17
Chuhan Zong, Michelle Jennifer Wu, Jason Z Qin, A James Link
Mechanically interlocked molecules that change their conformation in response to stimuli have been developed by synthetic chemists as building blocks for molecular machines. Here we describe a natural product, the lasso peptide benenodin-1, which exhibits conformational switching between two distinct threaded conformers upon actuation by heat. We have determined the structures of both conformers and have characterized the kinetics and energetics of the conformational switch. Single amino acid substitutions to benenodin-1 generate peptides that are biased to a single conformer, showing that the switching behavior is potentially an evolvable trait in these peptides...
July 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28696670/highly-efficient-photocatalyst-based-on-cds-quantum-dots-zno-nanosheets-0d-2d-heterojunction-for-h2-evolution-from-water-splitting
#18
Dandan Ma, Jian-Wen Shi, Yajun Zou, Zhaoyang Fan, Xin Ji, Chunming Niu
A novel CdS/ZnO heterojunction constructed by zero-dimensional (0D) CdS quantum dots (QDs) and two-dimensional (2D) ZnO nanosheets (NSs) was rationally designed for the first time. The 2D ZnO NSs were assembled into ZnO microflowers (MFs) via an ultrasonic-assisted hydrothermal procedure (100 ℃, 12 h) in the presence of NaOH solution (0.06 M), and CdS QDs were deposited on both sides of every ZnO nanosheet in-situ by using the successive ionic layer absorption and reaction method. It was found that the ultrasonic treatment played an important role in the generation of ZnO NSs, while NaOH was responsible to the assembly of flower-like structure...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28696146/heat-resistance-of-histidine-decarboxylase-from-gram-negative-histamine-producing-bacteria-in-seafood
#19
K Bjornsdottir-Butler, F A Bencsath, S McCarthy, R A Benner
Precooking of tuna is a potential critical control point (CCP) in the commercial manufacturing of canned tuna. To assess the efficacy of precooking as a CCP, an understanding of the thermal properties of histamine-producing bacteria (HPB) and their histidine decarboxylase (HDC) enzymes is required. The thermal properties of many HPB have been determined, but the thermal resistances of the HDC enzymes are unknown. The purpose of this study was to determine the D- and z-values of selected HDC enzymes to evaluate the CCP of precooking during the canning process and provide scientific data to support U...
July 11, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28692391/harnessing-syndromic-surveillance-emergency-department-data-to-monitor-health-impacts-during-the-2015-special-olympics-world-games
#20
Emily Kajita, Monica Z Luarca, Han Wu, Bessie Hwang, Laurene Mascola
INTRODUCTION: Mass gatherings that attract a large international presence may cause or amplify point-source outbreaks of emerging infectious disease. The Los Angeles County Department of Public Health customized its syndromic surveillance system to detect increased syndrome-specific utilization of emergency departments (EDs) and other medical encounters coincident to the 2015 Special Olympics World Games. MATERIALS AND METHODS: We queried live databases containing data on ED visits, California Poison Control System calls, and Los Angeles County coroner-investigated deaths for increases in daily counts from July 19 to August 6, 2015...
July 2017: Public Health Reports
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