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https://www.readbyqxmd.com/read/29346604/unique-genetic-profiles-from-cerebrospinal-fluid-cell-free-dna-in-leptomeningeal-metastases-of-egfr-mutant-non-small-cell-lung-cancer-a-new-medium-of-liquid-biopsy
#1
Y S Li, B Y Jiang, J J Yang, X C Zhang, Z Zhang, J Y Ye, W Z Zhong, H Y Tu, H J Chen, Z Wang, C R Xu, B C Wang, H J Du, S Chuai, H Han-Zhang, J Su, Q Zhou, X N Yang, W B Guo, H H Yan, Y H Liu, L X Yan, B Huang, M M Zheng, Y L Wu
Background: Leptomeningeal metastases (LM) are more frequent in non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Due to limited access to leptomeningeal lesions, the purpose of this study was to explore the potential role of cerebrospinal fluid (CSF) as a source of liquid biopsy in patients with LM. Patients and methods: Primary tumor, CSF, and plasma in NSCLC with LM were tested by next-generation sequencing. In total, 45 patients with suspected LM underwent lumbar puncture, and those with EGFR mutations diagnosed with LM were enrolled...
January 15, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29346327/enhanced-isotopic-ratio-outlier-analysis-iroa-peak-detection-and-identification-with-ultra-high-resolution-gc-orbitrap-ms-potential-application-for-investigation-of-model-organism-metabolomes
#2
Yunping Qiu, Robyn D Moir, Ian M Willis, Suresh Seethapathy, Robert C Biniakewitz, Irwin J Kurland
Identifying non-annotated peaks may have a significant impact on the understanding of biological systems. In silico methodologies have focused on ESI LC/MS/MS for identifying non-annotated MS peaks. In this study, we employed in silico methodology to develop an Isotopic Ratio Outlier Analysis (IROA) workflow using enhanced mass spectrometric data acquired with the ultra-high resolution GC-Orbitrap/MS to determine the identity of non-annotated metabolites. The higher resolution of the GC-Orbitrap/MS, together with its wide dynamic range, resulted in more IROA peak pairs detected, and increased reliability of chemical formulae generation (CFG)...
January 18, 2018: Metabolites
https://www.readbyqxmd.com/read/29345468/photochemistry-of-solid-films-of-the-neonicotinoid-nitenpyram
#3
Kifle Z Aregahegn, Michael J Ezell, Barbara J Finlayson-Pitts
The environmental fates of nitenpyram (NPM), a widely used neonicotinoid insecticide, are not well known. A thin solid film of NPM deposited on a germanium attenuated total reflectance (ATR) crystal was exposed to radiation from a low-pressure mercury lamp at 254 nm, or from broadband low pressure mercury photolysis lamps centered at 350 or 313 nm. The loss during photolysis was followed in time using FTIR. The photolysis quantum yields (), defined as the number of NPM molecules lost per photon absorbed, were determined to be (9...
January 18, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29344754/green-and-sustainable-separation-of-natural-products-from-agro-industrial-waste-challenges-potentialities-and-perspectives-on-emerging-approaches
#4
REVIEW
Vânia G Zuin, Luize Z Ramin
New generations of biorefinery combine innovative biomass waste resources from different origins, chemical extraction and/or synthesis of biomaterials, biofuels, and bioenergy via green and sustainable processes. From the very beginning, identifying and evaluating all potentially high value-added chemicals that could be removed from available renewable feedstocks requires robust, efficient, selective, reproducible, and benign analytical approaches. With this in mind, green and sustainable separation of natural products from agro-industrial waste is clearly attractive considering both socio-environmental and economic aspects...
January 17, 2018: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/29340384/kinetics-of-the-a-c3h5-o2-reaction-investigated-by-photoionization-using-synchrotron-radiation
#5
D Schleier, P Constantinidis, N Faßheber, I Fischer, G Friedrichs, P Hemberger, E Reusch, B Sztáray, K Voronova
The kinetics of the combustion-relevant reaction of the allyl radical, a-C3H5, with molecular oxygen has been studied in a flow tube reactor at the vacuum ultraviolet (VUV) beamline of the Swiss Light Source storage ring, using the CRF-PEPICO (Combustion Reactions Followed by Photoelectron Photoion Coincidence Spectroscopy) setup. The ability to measure threshold photoelectron spectra enables a background-free detection of reactive species as well as an isomer-specific analysis of reaction products. Allyl was generated by direct photodissociation of allyl iodide at 266 nm and 213 nm and indirectly by the reaction of propene with Cl atoms, which were generated by photolysis from oxalyl chloride at 266 nm...
January 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29339014/development-of-gpc3-specific-chimeric-antigen-receptor-engineered-natural-killer-cells-for-the-treatment-of-hepatocellular-carcinoma
#6
Min Yu, Hong Luo, Mingliang Fan, Xiuqi Wu, Bizhi Shi, Shengmeng Di, Ying Liu, Zeyan Pan, Hua Jiang, Zonghai Li
Chimeric antigen receptor (CAR)-modified natural killer (NK) cells represent a promising immunotherapeutic modality for cancer treatment. However, their potential utilities have not been explored in hepatocellular carcinoma (HCC). Glypian-3 (GPC3) is a rational immunotherapeutic target for HCC. In this study, we developed GPC3-specific NK cells and explored their potential in the treatment of HCC. The NK-92/9.28.z cell line was established by engineering NK-92, a highly cytotoxic NK cell line with second-generation GPC3-specific CAR...
December 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29338725/herbal-formula-ygjdsj-inhibits-anchorage-independent-growth-and-induces-anoikis-in-hepatocellular-carcinoma-bel-7402-cells
#7
Bing Hu, Tong Zhang, Hong-Mei An, Jia-Lu Zheng, Xia Yan, Xiao-Wei Huang
BACKGROUND: Based on clinical medications and related studies, we established a Yang-Gan Jie-Du Sang-Jie (YGJDSJ) herbal formula for hepatocarcinoma treatment. In present study, we evaluated the anti-cancer potential of YGJDSJ on suspension-grown human hepatocellular carcinoma Bel-7402 cells. METHODS: Bel-7402 cells were cultured in poly(2-hydroxyethyl methacrylate) (poly-HEMA) coated plates and treated with YGJDSJ. Anchorage-independent cell growth was detected by cell Counting Kit-8 (CCK-8) assay and soft agar colony formation assay...
January 16, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29338304/investigation-of-the-use-of-external-aluminum-targets-for-portal-imaging-in-a-medical-accelerator-using-geant4-monte-carlo-simulation
#8
Hyungdong Kim, Byungyong Kim, Jonggeun Baek, Youngkee Oh, Hyunsoo Jang
OBJECTIVE: To install a low-Z target on the wedge tray mount of a medical linear accelerator to create a new image beam and to confirm image contrast enhancement. METHODS: Experimental low-energy photon beams were produced with the linac running in the 6 MeV electron mode and with a low-Z target installed on the wedge tray mount (denoted 6 MeV (low-Z target)). Geant4 Monte Carlo simulation (MCS) was performed to analyze the energy spectrum and image contrast of a 6 MeV (low-Z target) beam...
January 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29335572/variation-and-constraints-in-hybrid-genome-formation
#9
Anna Runemark, Cassandra N Trier, Fabrice Eroukhmanoff, Jo S Hermansen, Michael Matschiner, Mark Ravinet, Tore O Elgvin, Glenn-Peter Sætre
Hybridization is an important source of variation; it transfers adaptive genetic variation across species boundaries and generates new species. Yet, the limits to viable hybrid genome formation are poorly understood. Here we investigated to what extent hybrid genomes are free to evolve by sequencing the genomes of four island populations of the homoploid hybrid Italian sparrow Passer italiae. We report that a variety of novel and fully functional hybrid genomic combinations are likely to have arisen independently on Crete, Corsica, Sicily and Malta, with differentiation in candidate genes for beak shape and plumage colour...
January 15, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29335515/ultrafast-consolidation-of-bulk-nanocrystalline-titanium-alloy-through-ultrasonic-vibration
#10
P Chen, W B Liao, L H Liu, F Luo, X Y Wu, P J Li, C Yang, M Yan, Y Liu, L C Zhang, Z Y Liu
Nanocrystalline (NC) materials have fascinating physical and chemical properties, thereby they exhibit great prospects in academic and industrial fields. Highly efficient approaches for fabricating bulk NC materials have been pursued extensively over past decades. However, the instability of nanograin, which is sensitive to processing parameters (such as temperature and time), is always a challenging issue to be solved and remains to date. Herein, we report an ultrafast nanostructuring strategy, namely ultrasonic vibration consolidation (UVC)...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29333884/use-of-tidal-breathing-curves-for-evaluating-expiratory-airway-obstruction-in-infants
#11
Avigdor Hevroni, Aliza Goldman, Miriam Blank-Brachfeld, Wiessam Abu Ahmad, Lior Ben-Dov, Chaim Springer
OBJECTIVE: To evaluate tidal breathing (TB) flow-volume and flow-time curves for identification of expiratory airway obstruction in infants. METHODS: Pulmonary function tests were analyzed retrospectively in 156 infants aged 3-24 months with persistent or recurrent respiratory complaints. Parameters derived from TB curves were compared to maximal expiratory flow at functional residual capacity ([Formula: see text]maxFRC) measured by rapid thoracoabdominal compression technique...
January 15, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29333632/binding-of-cu-and-cu2-with-peptides-peptides-oxytocin-arg8-vasopressin-bradykinin-angiotensin-i-substance-p-somatostatin-and-neurotensin
#12
Thankan Jayasekharan, Shyam L Gupta, Vikas Dhiman
The intrinsic binding ability of seven natural peptides (oxytocin, arg8 -vasopressin, bradykinin, angiotensin-I, substance-P, somatostatin, and neurotensin) with copper in two different oxidation states (CuI/II ) derived from different Cu+/2+ precursor sources have been investigated for their charge dependent binding characteristics. The peptide-CuI/II complexes, [M - (n-1)H + nCuI ] and [M - (2n-1)H + nCuII ] are prepared/generated by the reaction of peptides with CuI solution/Cu-target and CuSO4 solution, and are analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS)...
January 15, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29331915/theory-of-water-treatment-by-capacitive-deionization-with-redox-active-porous-electrodes
#13
Fan He, P M Biesheuvel, Martin Z Bazant, T Alan Hatton
Capacitive deionization (CDI) for water treatment, which relies on the capture of charged species to sustain the electrical double layers (EDLs) established within porous electrodes under an applied electrical potential, can be enhanced by the chemical attachment of fixed charged groups to the porous electrode electrodes (ECDI). It has recently been demonstrated that further improvements in capacity and energy storage can be gained by functionalization of the electrode surfaces with redox polymers in which the charge on the electrodes can be modulated through Faradaic reactions under different cell voltages in a capacitive process that can be called "Faradaic CDI" (FaCDI)...
January 3, 2018: Water Research
https://www.readbyqxmd.com/read/29331484/novel-biomolecular-information-in-rotenone-induced-cellular-model-of-parkinson-s-disease
#14
D Lin, Y Liang, D Zheng, Y Chen, X Jing, M Lei, Z Zeng, T Zhou, X Wu, S Peng, K Huang, L Yang, S Xiao, J Liu, E Tao
In order to uncover the remarkable pathogenic genes or molecular pathological process in Parkinson's disease (PD), we employed a microarray analysis upon the cellular PD model induced by rotenone. Compared to the control group, 2174 genes were screened out to be expressed differently in the rotenone-induced group by certain criterion. GO analysis and the pathways analysis showed the significant enrichment of genes that were associated with the biological process of cell cycle, apoptotic process, organelle fusion, mitochondrial lesion, endoplasmic reticulum stress and so on...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29330055/tissue-geometry-may-govern-lung-branching-mode-selection
#15
Uduak Z George, Sharon R Lubkin
Lung branching morphogenesis proceeds in three stereotyped modes (domain, planar, and orthogonal branching). Much is known about the molecular players, including growth factors such as fibroblast growth factor 10 but it is unknown how these signals could actuate the different branching patterns. With the aim of identifying mechanisms that may determine the different branching modes, we developed a computational model of the epithelial lung bud and its surrounding mesenchyme. We studied transport of morphogens and localization of morphogen flux at lobe surfaces and lobe edges...
January 9, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29330041/acute-epileptiform-activity-induced-by-gabazine-involves-proteasomal-rather-than-lysosomal-degradation-of-kca2-2-channels
#16
Steffen Müller, Xiati Guli, Judith Hey, Anne Einsle, Daniela Pfanz, Victor Sudmann, Timo Kirschstein, Rüdiger Köhling
Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In the acute in vitro epilepsy model induced in hippocampal brain slice preparations by exposure to the GABAA receptor blocker gabazine (GZ), the AHP was previously shown to be significantly decreased. Here, we asked the question whether KCa2...
January 9, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29328662/spin-orbit-torques-in-nbse2-permalloy-bilayers
#17
Marcos H D Guimarães, Gregory Stiehl, David MacNeill, Neal Reynolds, Daniel C Ralph
We present measurements of current-induced spin-orbit torques generated by NbSe2, a fully-metallic transition-metal dichalcogenide material, made using the spin-torque ferromagnetic resonance (ST-FMR) technique with NbSe2/Permalloy bilayers. In addition to the out-of-plane Oersted torque expected from current flow in the metallic NbSe2 layer, we also observe an in-plane antidamping torque with torque conductivity σ ∼ 103 (ħ / 2e) (Ωm)-1 and indications of a weak field-like contribution to the out-of-plane torque oriented opposite to the Oersted torque...
January 12, 2018: Nano Letters
https://www.readbyqxmd.com/read/29322591/inter-rater-agreement-of-novel-high-resolution-impedance-manometry-metrics-bolus-flow-time-and-esophageal-impedance-integral-ratio
#18
D A Carlson, Z Lin, W Kou, J E Pandolfino
BACKGROUND: Novel high-resolution impedance manometry (HRIM) metrics of bolus flow time (BFT) and esophageal impedance integral (EII) ratio have demonstrated clinical utility, though the reliability of their analysis has not been assessed. We aimed to evaluate the inter-rater agreement of the BFT and EII ratio. METHODS: HRIM studies including five upright, liquid swallows from 40 adult patients were analyzed by two raters using a customized MATLAB program to generate the BFT and EII ratio...
January 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29322460/real-time-digital-bright-field-technology-for-rapid-antibiotic-susceptibility-testing
#19
Chiara Canali, Erik Spillum, Martin Valvik, Niels Agersnap, Tom Olesen
Optical scanning through bacterial samples and image-based analysis may provide a robust method for bacterial identification, fast estimation of growth rates and their modulation due to the presence of antimicrobial agents. Here, we describe an automated digital, time-lapse, bright field imaging system (oCelloScope, BioSense Solutions ApS, Farum, Denmark) for rapid and higher throughput antibiotic susceptibility testing (AST) of up to 96 bacteria-antibiotic combinations at a time. The imaging system consists of a digital camera, an illumination unit and a lens where the optical axis is tilted 6...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29320190/electronic-and-nonlinear-optical-properties-of-l-histidine-on-silver-a-theoretical-and-experimental-approach
#20
U Reeta Felscia, Beulah J M Rajkumar, Monickaraj Nidya, Pranitha Sankar
Investigation on the electrostatic interactions between histidine and silver have been analysed using Density Functional Theory (DFT). Variations in the structural parameters were identified to be significant at those atoms of histidine near the silver cluster. Shifting of frontier molecular orbitals, reduction in bandgap, molecular electrostatic potential(MEP) and the overlap of Natural Bond Orbitals(NBO) between silver and histidine have been theoretically calculated. The results confirm the redistribution of charges consequent to the process of adsorption...
January 10, 2018: Journal of Physical Chemistry. A
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