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https://www.readbyqxmd.com/read/28647964/-association-between-single-nucleotide-polymorphism-of-bard1-gene-and-brca1-gene-mutation-in-epithelial-ovarian-cancer
#1
W L Liu, J Z Zhao, Z Z Wang, B Dong, Y Y Hou, X X Wu, Y J Guo
Objective: To investigate the relationship between single nucleotide polymorphism (SNP) of BARD1 gene and BRCA1 gene in epithelial ovarian cancer (EOC). Methods: Nineteen EOC patients with BRCA1 gene mutation and 50 EOC cases without BRCA1 gene mutation between January 2016 and October 2016 were collected, and all EOC were diagnosed by pathological method. BARD1 gene variants were detected by next generation sequencing (NGS). The SNP of BARD1 gene was analyzed by Pearson linear correlation. Logistic regression analysis was used to research the clinicopathologic features and BRCA1 gene mutation associated with BARD1 gene SNP...
June 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28644909/a-highly-efficient-synthesis-of-z-macrocycles-using-stereoretentive-ruthenium-based-metathesis-catalysts
#2
Tonia Sarah Ahmed, Robert H Grubbs
A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at -20 °C within 10 min. Macrocyclization reactions generated Z-products from easily accessible diene starting materials bearing a Z-olefin moiety. This stereoretentive approach provides a more efficient and selective route to Z-macrocyles than in previously reported systems...
June 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28644656/entanglement-enhanced-phase-estimation-without-prior-phase-information
#3
G Colangelo, F Martin Ciurana, G Puentes, M W Mitchell, R J Sewell
We study the generation of planar quantum squeezed (PQS) states by quantum nondemolition (QND) measurement of an ensemble of ^{87}Rb atoms with a Poisson distributed atom number. Precise calibration of the QND measurement allows us to infer the conditional covariance matrix describing the F_{y} and F_{z} components of the PQS states, revealing the dual squeezing characteristic of PQS states. PQS states have been proposed for single-shot phase estimation without prior knowledge of the likely values of the phase...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28643367/facile-one-pot-synthesis-of-functional-giant-polymeric-vesicles-controlled-by-oscillatory-chemistry
#4
Bishnu Bastakoti, Juan Perez-Mercader
We introduce a novel application of an oscillatory chemical reaction to the synthesis of block copolymers. The Belousov-Zhabotinsky (B-Z) reaction is coupled with the polymerization of an amphiphilic block copolymer. Radicals generated in the B-Z reaction initiate the polymerization between a polyethylene glycol (PEG) macro reversible addition-fragmentation chain transfer agent and butyl acrylate monomers. The growth of the hydrophobic block on PEG undergoes self-assembly to form spherical micelles. The nanoscale micelles transform into submicron vesicles and grow to giant vesicles as a consequence of the oscillatory behavior of the B-Z reaction...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28641860/noninvasive-blood-potassium-measurement-using-signal-processed-single-lead-ecg-acquired-from-a-handheld-smartphone
#5
Omar Z Yasin, Zachi Attia, John J Dillon, Christopher V DeSimone, Yehu Sapir, Jennifer Dugan, Virend K Somers, Michael J Ackerman, Samuel J Asirvatham, Christopher G Scott, Kevin E Bennet, Dorothy J Ladewig, Dan Sadot, Amir B Geva, Paul A Friedman
OBJECTIVE: We have previously used a 12-lead, signal-processed ECG to calculate blood potassium levels. We now assess the feasibility of doing so with a smartphone-enabled single lead, to permit remote monitoring. PATIENTS AND METHODS: Twenty-one hemodialysis patients held a smartphone equipped with inexpensive FDA-approved electrodes for three 2min intervals during hemodialysis. Individualized potassium estimation models were generated for each patient. ECG-calculated potassium values were compared to blood potassium results at subsequent visits to evaluate the accuracy of the potassium estimation models...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28641475/care-and-not-wealth-is-a-predictor-of-wasting-and-stunting-of-the-coffee-kids-of-jimma-zone-southwest-ethiopia
#6
Kalkidan Hassen Abate, Tefera Belachew
BACKGROUND: The generation of cash from agricultural products is the mainstay of the livelihood of many households in developing countries. However, critics of cash cropping have highlighted its influence on dietary diversity and availability of food at the household level, eroding the potential for optimal child caring practices. METHODS: A community-based cross-sectional survey was carried out in three randomly selected coffee-producing districts of Jimma Zone in southwest Ethiopia...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28640892/novel-resistance-to-cydia-pomonella-granulovirus-cpgv-in-codling-moth-shows-autosomal-and-dominant-inheritance-and-confers-cross-resistance-to-different-cpgv-genome-groups
#7
Annette J Sauer, Eva Fritsch, Karin Undorf-Spahn, Petr Nguyen, Frantisek Marec, David G Heckel, Johannes A Jehle
Commercial Cydia pomonella granulovirus (CpGV) products have been successfully applied to control codling moth (CM) in organic and integrated fruit production for more than 30 years. Since 2005, resistance against the widely used isolate CpGV-M has been reported from different countries in Europe. The inheritance of this so-called type I resistance is dominant and linked to the Z chromosome. Recently, a second form (type II) of CpGV resistance in CM was reported from a field population (NRW-WE) in Germany. Type II resistance confers reduced susceptibility not only to CpGV-M but to most known CpGV isolates and it does not follow the previously described Z-linked inheritance of type I resistance...
2017: PloS One
https://www.readbyqxmd.com/read/28637662/daratumumab-plus-pomalidomide-and-dexamethasone-in-relapsed-and-or-refractory-multiple-myeloma
#8
Ajai Chari, Attaya Suvannasankha, Joseph W Fay, Bertrand Arnulf, Jonathan L Kaufman, Jainulabdeen J Ifthikharuddin, Brendan M Weiss, Amrita Krishnan, Suzanne Lentzsch, Raymond Comenzo, Jianping Wang, Kerri Nottage, Christopher Chiu, Nushmia Z Khokhar, Tahamtan Ahmadi, Sagar Lonial
Daratumumab plus pomalidomide/dexamethasone (pom-dex) was evaluated in patients with relapsed/refractory multiple myeloma with ≥2 prior lines of therapy, and who were refractory to their last treatment. Patients received daratumumab 16 mg/kg at the recommended dosing schedule, pomalidomide 4 mg daily for 21 days of each 28-day cycle, and dexamethasone 40 mg weekly. Safety was the primary endpoint. Overall response rate (ORR) and minimal residual disease (MRD) by next-generation sequencing were secondary endpoints...
June 21, 2017: Blood
https://www.readbyqxmd.com/read/28636338/contributions-of-local-farming-to-urban-sustainability-in-the-northeast-united-states
#9
Benjamin P Goldstein, Michael Z Hauschild, John E Fernández, Morten Birkved
Food consumption is an important contributor to a city's environmental impacts (carbon emissions, land occupation, water use, etc.) Urban farming (UF) has been advocated as a means to increase urban sustainability by reducing food-related transport and tapping into local resources. Taking Boston as an illustrative Northeast U.S. city, we developed a novel method to estimate sub-urban, food-borne carbon and land footprints using multiregion-input-output modeling and nutritional surveys. Computer simulations utilizing primary data explored UF's ability to reduce these footprints using select farming technologies, building on previous city-scale UF assessments which have hitherto been dependent on proxy data for UF...
June 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28636010/engineering-multi-functional-bacterial-outer-membrane-vesicles-as-modular-nanodevices-for-biosensing-and-bioimaging
#10
Qi Chen, Sharon Rozovsky, Wilfred Chen
Outer membrane vesicles (OMVs) are proteoliposomes derived from the outer membrane and periplasmic space of many Gram-negative bacteria including E. coli as part of their natural growth cycle. Inspired by the natural ability of E. coli to sort proteins to both the exterior and interior of OMVs, we reported here a one-pot synthesis approach to engineer multi-functionalized OMV-based sensors for both antigen binding and signal generation. SlyB, a native lipoprotein, was used a fusion partner to package nanoluciferase (Nluc) within OMVs, while a previously developed INP-Scaf3 surface scaffold was fused to the Z-domain for antibody recruiting...
June 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28630339/ucp1-deficiency-causes-brown-fat-respiratory-chain-depletion-and-sensitizes-mitochondria-to-calcium-overload-induced-dysfunction
#11
Lawrence Kazak, Edward T Chouchani, Irina G Stavrovskaya, Gina Z Lu, Mark P Jedrychowski, Daniel F Egan, Manju Kumari, Xingxing Kong, Brian K Erickson, John Szpyt, Evan D Rosen, Michael P Murphy, Bruce S Kristal, Steven P Gygi, Bruce M Spiegelman
Brown adipose tissue (BAT) mitochondria exhibit high oxidative capacity and abundant expression of both electron transport chain components and uncoupling protein 1 (UCP1). UCP1 dissipates the mitochondrial proton motive force (Δp) generated by the respiratory chain and increases thermogenesis. Here we find that in mice genetically lacking UCP1, cold-induced activation of metabolism triggers innate immune signaling and markers of cell death in BAT. Moreover, global proteomic analysis reveals that this cascade induced by UCP1 deletion is associated with a dramatic reduction in electron transport chain abundance...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629996/production-of-medically-useful-nitric-monoxide-using-ac-arc-discharge
#12
S R Li, Y F Huang, Z Liu, M H Sui, J M Liu, K P Yan
Inhaled nitric monoxide (iNO) is increasingly used as a medical treatment for acute respiratory distress syndrome. A course of the existing nitric monoxide (NO) therapy with gas cylinders could cost up to approximately $15,000 for an average of 30.2 h. Moreover, a gas cylinder containing a mixture of N2 and NO may potentially leak NO. The objective of this study is to develop an efficient and cost-effective on-site iNO generation system. In the present setup, NO was generated by using dry air or mixed oxygen/nitrogen (O2/N2) and an AC power source with an output power level of 5-30 W at atmospheric pressure...
June 16, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28628887/determining-concentrations-of-elements-with-different-reaction-channels-in-photon-activation
#13
Z J Sun, K Okafor, S Isa
In photon activation, same element may be activated by the bremsstrahlung beam through different nuclear reaction channels and produce different radioisotopes. These radioisotopes follow their own decay schemes and generate characteristic gamma rays. This phenomenon usually is an interference in spectra analysis, but it also offers a theoretical feasibility to determine the concentration of one element through different reaction channels. To realize this theoretical feasibility, we conducted series of photon activation experiments with sample and reference of known concentrations...
June 13, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28628034/clonal-expansion-of-genome-intact-hiv-1-in-functionally-polarized-th1-cd4-t-cells
#14
Guinevere Q Lee, Nina Orlova-Fink, Kevin Einkauf, Fatema Z Chowdhury, Xiaoming Sun, Sean Harrington, Hsiao-Hsuan Kuo, Stephane Hua, Hsiao-Rong Chen, Zhengyu Ouyang, Kavidha Reddy, Krista Dong, Thumbi Ndung'u, Bruce D Walker, Eric S Rosenberg, Xu G Yu, Mathias Lichterfeld
HIV-1 causes a chronic, incurable disease due to its persistence in CD4+ T cells that contain replication-competent provirus, but exhibit little or no active viral gene expression and effectively resist combination antiretroviral therapy (cART). These latently infected T cells represent an extremely small proportion of all circulating CD4+ T cells but possess a remarkable long-term stability and typically persist throughout life, for reasons that are not fully understood. Here we performed massive single-genome, near-full-length next-generation sequencing of HIV-1 DNA derived from unfractionated peripheral blood mononuclear cells, ex vivo-isolated CD4+ T cells, and subsets of functionally polarized memory CD4+ T cells...
June 19, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28627406/multi-omics-facilitated-variable-selection-in-cox-regression-model-for-cancer-prognosis-prediction
#15
Cong Liu, Xujun Wang, Georgi Z Genchev, Hui Lu
Motivation New developments in high-throughput genomic technologies have enabled the measurement of diverse types of omics biomarkers in a cost-efficient and clinically-feasible manner. Developing computational methods and tools for analysis and translation of such genomic data into clinically-relevant information is an ongoing and active area of investigation. For example, several studies have utilized an unsupervised learning framework to cluster patients by integrating omics data. Despite such recent advances, predicting cancer prognosis using integrated omics biomarkers remains a challenge...
June 13, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28626027/selective-activation-of-epidermal-growth-factor-receptor-in-renal-proximal-tubule-induces-tubulointerstitial-fibrosis
#16
Jessica M Overstreet, Yinqiu Wang, Xin Wang, Aolei Niu, Leslie S Gewin, Bing Yao, Raymond C Harris, Ming-Zhi Zhang
Epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis of diabetic nephropathy and renal fibrosis; however, the causative role of sustained EGFR activation is unclear. Here, we generated a novel kidney fibrotic mouse model of persistent EGFR activation by selectively expressing the EGFR ligand, human heparin-binding EGF-like growth factor (HB-EGF), in renal proximal tubule epithelium. Human HB-EGF expression increased tyrosine kinase phosphorylation of EGFR and the subsequent activation of downstream signaling pathways, including ERK and AKT, as well as the profibrotic TGF-β1/SMAD pathway...
June 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28624971/excelautomat-a-tool-for-systematic-processing-of-files-as-applied-to-quantum-chemical-calculations
#17
Jalal Z A Laloo, Nassirah Laloo, Lydia Rhyman, Ponnadurai Ramasami
The processing of the input and output files of quantum chemical calculations often necessitates a spreadsheet as a key component of the workflow. Spreadsheet packages with a built-in programming language editor can automate the steps involved and thus provide a direct link between processing files and the spreadsheet. This helps to reduce user-interventions as well as the need to switch between different programs to carry out each step. The ExcelAutomat tool is the implementation of this method in Microsoft Excel (MS Excel) using the default Visual Basic for Application (VBA) programming language...
June 17, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28624679/neuraminidase-based-recombinant-virus-like-particles-protect-against-lethal-avian-influenza-a-h5n1-virus-infection-in-ferrets
#18
Gale E Smith, Xiangjie Sun, Yaohui Bai, Ye V Liu, Michael J Massare, Melissa B Pearce, Jessica A Belser, Taronna R Maines, Hannah M Creager, Gregory M Glenn, David Flyer, Peter Pushko, Min Z Levine, Terrence M Tumpey
Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian influenza subtypes. Influenza neuraminidase (NA) vaccines represent a potential strategy for improving vaccines against avian influenza H5N1 viruses. To evaluate a strategy for NA vaccination, we generated a recombinant influenza virus-like particle (VLP) vaccine comprised of the NA protein of A/Indonesia/05/2005 (H5N1) virus...
June 15, 2017: Virology
https://www.readbyqxmd.com/read/28621347/nonlinear-optical-properties-upconversion-and-lasing-in-metal-organic-frameworks
#19
REVIEW
Raghavender Medishetty, Jan K Zaręba, David Mayer, Marek Samoć, Roland A Fischer
The building block modular approach that lies behind coordination polymers (CPs) and metal-organic frameworks (MOFs) results not only in a plethora of materials that can be obtained but also in a vast array of material properties that could be aimed at. Optical properties appear to be particularly predetermined by the character of individual structural units and by the intricate interplay between them. Indeed, the "design principles" shaping the optical properties of these materials seem to be well explored for luminescence and second-harmonic generation (SHG) phenomena; these have been covered in numerous previous reviews...
June 16, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28620780/a-novel-large-fragment-deletion-in-pls3-causes-rare-x-linked-early-onset-osteoporosis-and-response-to-zoledronic-acid
#20
F Lv, M Ma, W Liu, X Xu, Y Song, L Li, Y Jiang, O Wang, W Xia, X Xing, Z Qiu, M Li
We identified a novel large fragment deletion from intron 9 to 3'UTR in PLS3 (E10-E16del) in one Chinese boy with X-linked early-onset osteoporosis and vertebral fractures, which expanded the pathogenic spectrum of X-linked early-onset osteoporosis. Treatment with zoledronic acid was beneficial for increasing BMD and reshaping the vertebral bodies of this patient. INTRODUCTION: X-linked early-onset osteoporosis is a rare disease, which is characterized by low bone mineral density (BMD), vertebral compression fractures (VCFs), and/or long bone fractures...
June 16, 2017: Osteoporosis International
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