keyword
https://read.qxmd.com/read/38527183/topical-insulin-for-ocular-surface-disease
#1
JOURNAL ARTICLE
Pau Cid-Bertomeu, Magí Vilaltella, Mireia Martínez, Marta Mir, Valentín Huerva
Background: Insulin and insulin-like growth factor (IGF)-1 receptors are present in ocular tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a crucial role in the growth, differentiation, and proliferation of corneal epithelial cells, as well as in wound healing processes in various tissues. Purpose: This review explores the potential role of topical insulin in the treatment of ocular surface diseases. Specifically, it examines its impact on corneal nerve regeneration, sub-basal plexus corneal nerves, and its application in conditions like corneal epithelial defects, dry eye disease, and diabetic keratopathy...
March 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38521443/new-disposable-esthesiometer-kerasense%C3%A2-to-improve-diagnosis-and-management-of-neurotrophic-keratitis
#2
JOURNAL ARTICLE
Francesca Giovannetti, Marta Sacchetti, Marco Marenco, Ludovico Alisi, Giacomo Visioli, Alice Bruscolini, Alessandro Lambiase
PURPOSE: To validate the use, repeatability, and reproducibility of a new, cost-effective, disposable, sterile device (KeraSenseⓇ, Dompè farmaceutici SpA, Milan Italy) compared to Cochet-Bonnet (CB) esthesiometer. Secondly, to identify a simple, safe, rapid, and low-cost test to diagnose neurotrophic keratitis (NK). METHODS: 16 patients with diagnosis of NK stage I, 25 patients with diabetes mellitus (DM), and 26 healthy subjects were included in the study...
March 21, 2024: Ocular Surface
https://read.qxmd.com/read/38474343/chemical-alkali-burn-induced-neurotrophic-keratitis-model-in-new-zealand-rabbit-investigated-using-medical-clinical-readouts-and-in-vivo-confocal-microscopy-ivcm
#3
JOURNAL ARTICLE
Mehak Vohra, Abha Gour, Jyoti Rajput, Bharti Sangwan, Monika Chauhan, Kartik Goel, Ajith Kamath, Umang Mathur, Arun Chandru, Virender Singh Sangwan, Tuhin Bhowmick, Anil Tiwari
PURPOSE: Chemical eye injury is an acute emergency that can result in vision loss. Neurotrophic keratitis (NK) is the most common long-term manifestation of chemical injury. NK due to alkali burn affects ocular surface health and is one of its most common causes. Here, we established a rabbit model of corneal alkali burns to evaluate the severity of NK-associated changes. MATERIAL METHODS: Alkali burns were induced in NZ rabbits by treating the cornea with (i) a 5 mm circular filter paper soaked in 0...
February 22, 2024: Cells
https://read.qxmd.com/read/38456834/persistent-and-severe-mpox-keratitis-despite-systemic-and-topical-treatment
#4
JOURNAL ARTICLE
Laura Domínguez García, Almudena Gutierrez-Arroyo, Rosa Miguel-Buckley, Ana Martin Ucero, Juan Cantizani, Ana Boto-de-Los-Bueis
PURPOSE: The purpose of this study was to report a case of peripheral ulcerative keratitis in a patient diagnosed with corneal polymerase chain reaction (PCR) and a positive mpox culture. METHODS: This is a case report. RESULTS: An immunocompetent 54-year-old man was diagnosed with conjunctivitis in his left eye 15 days after being diagnosed with mucocutaneous monkeypox. He received treatment with dexamethasone 0.1% and tobramycin 0.3% eye drops for 2 weeks...
March 7, 2024: Cornea
https://read.qxmd.com/read/38427335/effect-of-topical-recombinant-human-nerve-growth-factor-on-corneal-epithelial-regeneration-in-refractory-epithelial-keratopathy
#5
JOURNAL ARTICLE
Xi Dai, Ugur Tunc, Xi Zhu, Sezen Karakus
PURPOSE: To report the effect of topical application of recombinant human nerve growth factor (rhNGF) eye drops on corneal epithelial regeneration in patients with refractory epitheliopathy. METHODS: A retrospective chart review was conducted on patients treated with topical rhNGF for refractory epithelial keratopathy due to stage I neurotrophic keratitis (NK). Data regarding demographics and ocular/systemic past medical history was extracted from patient charts...
March 1, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38275838/herpes-simplex-virus-type-1-modifies-the-protein-composition-of-extracellular-vesicles-to-promote-neurite-outgrowth-and-neuroinfection
#6
JOURNAL ARTICLE
Guorong Sun, Kai Alexander Kropp, Marieluise Kirchner, Nina Plückebaum, Anton Selich, Manutea Serrero, Akshay Dhingra, Jorge Rubén Cabrera, Birgit Ritter, Rudolf Bauerfeind, Emanuel Wyler, Markus Landthaler, Axel Schambach, Beate Sodeik, Philipp Mertins, Abel Viejo-Borbolla
The highly prevalent herpes simplex virus type 1 (HSV-1) causes a range of diseases, including cold sores, blinding keratitis, and life-threatening encephalitis. HSV-1 initially replicates in epithelial cells, enters the peripheral nervous system via neurites, and establishes lifelong infection in the neuronal cell bodies. Neurites are highly dynamic structures that grow or retract in response to attractive or repulsive cues, respectively. Here, we show that infection with HSV-1, but not with a mutant virus lacking glycoprotein G (gG), reduced the repulsive effect of epithelial cells on neurite outgrowth and facilitated HSV-1 invasion of neurons...
January 26, 2024: MBio
https://read.qxmd.com/read/38271428/selective-bowman-s-layer-transplantation-in-the-treatment-of-neurotrophic-corneal-ulcers
#7
JOURNAL ARTICLE
Diana Wyroślak-Bednarek, Milena Skrzypska, Anna Górnik, Piotr Jurowski
The aim of this paper is to present the surgical technique of selective Bowman's layer transplantation as well as the results of the surgery in patients with trophic corneal ulcers. The methodology of the study included three eyes from three patients with neurotrophic corneal ulcers grafting with corneal Bowman's layer. Pre- and postoperative analyses of the anterior segment of the eye were based on optical coherence tomography and slit-lamp assessment. Postoperatively a gradual corneal stroma restoration and fast corneal epithelialization were noticed...
February 1, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38254249/neurotrophic-keratopathy-after-wide-retinal-endolaser-and-postoperative-ketorolac-eye-drops-a-case-series
#8
JOURNAL ARTICLE
Giovanni Fossati, Elena Bartoli, Alessio Montericcio, Matilde Buzzi, Gianmaria Barone, Francesco Santoru, Davide Allegrini, Mario R Romano, Claudio Panico
PURPOSE: We report a series of 5 cases, happened in a period of 5 months, who developed neurotrophic keratopathy (NK) following pars plana vitrectomy (PPV) and retinal endolaser for rhegmatogenous retinal detachment (RRD). In our several decennary experience of surgical center predominantly based on vitreoretinal surgery, we had rare cases of postoperative NK. These recent cases of post-surgical NK happened contextually to our change of postoperative non-steroidal anti-inflammatory drugs (NSAIDs) drops, based on Ketorolac Tromethamine 0...
January 22, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38175466/phase-iv-multicenter-prospective-open-label-clinical-trial-of-cenegermin-rhngf-for-stage-1-neurotrophic-keratopathy-defendo
#9
JOURNAL ARTICLE
Pedram Hamrah, Mina Massaro-Giordano, David Schanzlin, Edward Holland, Gregg Berdy, Giovanni Goisis, Georgea Pasedis, Flavio Mantelli
INTRODUCTION: Cenegermin is approved for treatment of neurotrophic keratopathy (NK) and has been studied in patients with stage 2 or 3 NK. This study evaluated the efficacy and safety of cenegermin in adults with stage 1 NK. METHODS: This was a phase IV, multicenter, prospective, open-label, uncontrolled trial. Adults with stage 1 NK (Mackie criteria) and decreased corneal sensitivity (≤ 4 cm) received 1 drop of cenegermin 20 mcg/ml in the affected eye(s) 6 times/day for 8 weeks with a 24-week follow-up...
January 4, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38163580/krupple-like-factor-4-klf4-methylation-signature-in-host-cell-in-active-viral-keratitis-with-epithelial-manifestation
#10
JOURNAL ARTICLE
Vatsala Nidhi, Jyoti Sangwan, Swati Sood, Moumita Mondal, Bharti Sangwan, Mehak Vohra, Abha Gour, Umang Mathur, Virender Singh Sangwan, Manisha Acharya, Anil Tiwari
HSV1 presents as epithelial or stromal keratitis or keratouveitis and can lead to sight-threatening complications. KLF4, a critical transcription factor, and regulator of cell growth and differentiation, is essential in corneal epithelium stratification and homeostasis. Here, we want to understand the epigenetic modification specifically the methylation status of KLF4 in epithelium samples of HSV1 keratitis patients. After obtaining consent, epithelial scrapes were collected from 7 patients with clinically diagnosed HSV1 keratitis and 7 control samples (patients undergoing photorefractive keratectomy)...
December 30, 2023: Experimental Eye Research
https://read.qxmd.com/read/38160214/efficacy-of-plasma-rich-in-growth-factors-prgf-in-stage-1-neurotrophic-keratitis
#11
JOURNAL ARTICLE
Seyyedehfatemeh Ghalibafan, Kwaku A Osei, Guillermo Amescua, Alfonso L Sabater
No abstract text is available yet for this article.
December 30, 2023: Eye
https://read.qxmd.com/read/38145371/three-strategies-to-induce-neurotrophic-keratitis-and-nerve-regeneration-in-murine-cornea
#12
JOURNAL ARTICLE
Léna Meneux, Alicia Caballero, Hassan Boukhaddaoui, Frederic Michon
The cornea is a transparent tissue that covers the eye and is crucial for clear vision. It is the most innervated tissue in the body. This innervation provides sensation and trophic function to the eye and contributes to preserving corneal integrity. The pathological disruption of this innervation is termed neurotrophic keratitis. This can be triggered by injury to the eye, surgery, or disease. In this study, we propose three different protocols for inflicting damage on the innervation in ways that recapitulate the three types of cases generally encountered in the clinic...
December 8, 2023: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38130153/neurotrophic-keratopathy-clinical-presentation-and-outcomes-in-354-eyes-in-a-community-based-population
#13
JOURNAL ARTICLE
Catherine J Choi, Liyan Liu, Ying Qian, Lisa J Herrinton
PURPOSE: To describe the frequency, clinical presentation, and outcomes of neurotrophic keratopathy (NK). METHODS: Retrospective cohort study of Kaiser Permanente Northern California patients diagnosed with NK using ICD-10 code H16.23X from October 1, 2016 through May 31, 2021 was conducted. The electronic medical record was used to obtain demographic information, systemic and ocular comorbidities, corrected distance visual acuity (CDVA), Mackie stage, laterality, etiology, complications, interventions, and medications...
December 21, 2023: European Journal of Ophthalmology
https://read.qxmd.com/read/38038483/diagnostic-performance-of-real-time-quantitative-pcr-in-tear-samples-in-various-subtypes-of-herpes-simplex-keratitis
#14
JOURNAL ARTICLE
Gautier Hoarau, Oscar Haigh, Christelle Vauloup-Fellous, Rafaël Boucher, Alexandra Rouquette, Pascale Faure, Lamia Limam, Marc Labetoulle, Antoine Rousseau
Diagnosis of herpes simplex keratitis (HSK) is mostly based on clinical findings, yet biological confirmation supports management of challenging cases. This study evaluated the place of real-time quantitative PCR (RT-qPCR) on tear samplings in the management of HSK. Clinical records of patients who underwent tear sampling tested by RT-qPCR for herpes simplex virus type 1 for an acute episode of corneal inflammation or defect between January 2013 and December 2021 were retrospectively reviewed, and results were compared to clinical diagnosis (i...
December 1, 2023: Journal of Clinical Microbiology
https://read.qxmd.com/read/37965220/effect-of-recombinant-human-nerve-growth-factor-treatment-on-corneal-nerve-regeneration-in-patients-with-neurotrophic-keratopathy
#15
JOURNAL ARTICLE
Ana Balbuena-Pareja, Chloe S Bogen, Stephanie M Cox, Pedram Hamrah
INTRODUCTION: Neurotrophic Keratopathy (NK) is a neurodegenerative corneal disease that results in diminished corneal sensation. Previous studies have found that Cenegermin 0.002%, a recombinant human nerve growth factor (rhNGF), improves corneal epithelial healing in stage 2 and 3 NK patients. However, rhNGF effect on corneal sensation and nerve regeneration has not been well established. Thus, this study aims to analyze the effect of rhNGF on corneal nerve regeneration using in vivo confocal microscopy (IVCM) and on corneal sensitivity in NK patients...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/37908963/neurotrophic-keratopathy-and-topical-insulin-therapy-a-case-report
#16
Maryum Khilji, Shafiq Tanveer, Fahd Zafar Khan, Dilawar Ali Yazdan, Ayesha Khilji
Neurotrophic keratopathy is a rare disorder caused by the loss of corneal sensation. It is characterized by persistent epithelial defects, corneal ulceration, and, ultimately, corneal perforation if not managed in a timely manner. The management includes aggressive lubrication, prophylactic topical antibiotics, therapeutic contact lenses, tarsorrhaphy, and amniotic membrane transplantation. Some novel therapeutic options are also available, one of which is topical insulin therapy. We report the clinical course of a patient with neurotrophic keratopathy that was successfully treated with topical insulin...
September 2023: Curēus
https://read.qxmd.com/read/37901631/severe-corneal-melt-post-trans-scleral-cyclodiode-in-a-case-of-neovascular-glaucoma-secondary-to-coats-disease-a-case-report
#17
Jackson Chee Chea Lee, Geoffrey Zhi Peng Chan, Humma Shahid
A novel case of neurotrophic keratitis and severe corneal melt requiring surgical management is presented 1 month following trans-scleral cyclodiode for Coats disease and neovascular glaucoma. Risk factors contributing to the complication include previous extracapsular cataract surgery, perioperative use of topical non-steroidal anti-inflammatories and dexamethasone/neomycin, as well as other topical drops containing preservatives such as benzalkonium chloride. Meticulous consideration of preoptimization of the ocular surface and rationalization of perioperative eye drop regimes is discussed...
2023: Case Reports in Ophthalmology
https://read.qxmd.com/read/37879107/outcomes-and-success-of-amniotic-membrane-transplantation-for-the-treatment-of-corneal-diseases
#18
JOURNAL ARTICLE
Ozlem Dikmetas, Yasemin Kapucu, Ali Bülent Cankaya, Sibel Kocabeyoglu
PURPOSE: The amniotic membrane (AM), the inner layer of the placenta, is a semitransparent, avascular and thin tissue that is useful due to its structure. Amniotic membrane transplantation (AMT) avoids the need for keratoplasty to prevent corneal perforating. The purpose of the study was to evaluate the visual (gain of or no change in visual acuity) and corneal outcomes (closure of the ulcer or corneal healing) of AMT in patients with ocular surface diseases. MATERIALS AND METHODS: This was a retrospective case control study (success or failure of the surgery)...
October 25, 2023: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/37705757/use-of-prose-for-long-term-ocular-surface-support-in-patients-with-a-permanent-keratoprosthesis
#19
Bita Asghari, Karen G Carrasquillo, Alan Kwok, Kimberly C Sippel
PURPOSE: To describe the long-term outcome of the use of a specialized scleral lens known as a prosthetic replacement of the ocular surface ecosystem (PROSE) device to support the ocular surface in patients with a Boston Keratoprosthesis (KPro) Type I. All patients in this series were unable to pursue continuous wear of a bandage soft contact lens (BSCL) - a critical aspect of post KPro implantation management intended to protect the corneal carrier tissue from desiccation and stromal melting...
December 2023: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/37694830/neurotrophic-keratitis-inflammatory-pathogenesis-and-novel-therapies
#20
JOURNAL ARTICLE
Denise Wajnsztajn, Lana A Faraj, Sara Sanchez-Tabernero, Abraham Solomon
PURPOSE OF REVIEW: Neurotrophic keratitis is a rare degenerative disease characterized by decrease or absence of corneal sensation. Neurotrophic keratitis varies from mild forms with mild epitheliopathy to severe manifestations such as corneal ulceration, melting and perforation that can lead to irreversible visual loss. The cause of neurotrophic keratitis comprises a long list of diseases, medications, congenital or genetic conditions as well as trauma. The mechanism of neurotrophic keratitis is complex and multifactorial and its understanding is crucial to better address the treatment strategies...
September 8, 2023: Current Opinion in Allergy and Clinical Immunology
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