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https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#1
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551850/microrna-211-expression-is-down-regulated-and-associated-with-poor-prognosis-in-human-glioma
#2
Jun Zhang, Jianguang Lv, Feng Zhang, Hongmin Che, Qiwei Liao, Wobin Huang, Shaopeng Li, Yuqian Li
Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well as its correlation with patient prognosis. Glioma tissues and adjacent normal brain tissues were obtained from 82 patients who underwent surgical resection, and quantitative real-time polymerase chain reaction was performed to assess the expression level of miR-211...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551848/mri-features-of-pediatric-intracranial-germ-cell-tumor-subtypes
#3
Chih-Chun Wu, Wan-Yuo Guo, Feng-Chi Chang, Chao-Bao Luo, Han-Jui Lee, Yi-Wei Chen, Yi-Yen Lee, Tai-Tong Wong
Intracranial germ cell tumors differ in histology and location, and require different clinical management strategies. We characterized the imaging features that may aid pre-operative differentiation of intracranial germinomas and non-germinomatous germ cell tumors (NGGCTs). This retrospective study analyzed 85 patients with intracranial germ cell tumors and adequate preoperative or pretreatment MRIs between 2000 and 2013 at our institution. Pretreatment MRI characteristics, apparent diffusion coefficient (ADC) values, tumor histopathology, and patient outcomes were compared...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551847/prior-malignancies-in-patients-harboring-glioblastoma-an-institutional-case-study-of-2164-patients
#4
REVIEW
Brad E Zacharia, Natalie DiStefano, Marius M Mader, Muhammad O Chohan, Shahiba Ogilvie, Cameron Brennan, Philip Gutin, Viviane Tabar
More patients are surviving long-term following a cancer diagnosis and as such are at risk for second malignancies. As the most common primary brain tumor, glioblastoma (GBM) will not infrequently occur in this population. No study has examined the incidence of prior cancer (PC) in patients harboring GBM. Here we evaluate the epidemiological features, as well as the molecular and clinical characteristics of GBM as a second cancer. Utilizing a web-based cancer data management system at our institution, we identified 2164 patients harboring GBM from 2007 to 2014...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551845/sostdc1-inhibits-follicular-thyroid-cancer-cell-proliferation-migration-and-emt-via-suppressing-pi3k-akt-and-mapk-erk-signaling-pathways
#5
Qinyi Zhou, Jun Chen, Jialin Feng, Yanan Xu, Wenjie Zheng, Jiadong Wang
The sclerostin domain containing protein 1 (SOSTDC1) is a cell signaling regulator involved in cell physiology and pathology. SOSTDC1 is known to have a suppressive effect on certain kinds of cancer. However, the role of SOSTDC1 in follicular thyroid cancer (FTC) remains unknown. We aimed to investigate if the expression of SOSTDC1 plays any roles in carcinogenesis and metastasis of FTC. We found a significantly down-regulated SOSTDC1 expression in follicular thyroid cancer samples. In addition, our data showed that ectopic expression of SOSTDC1 dramatically inhibited thyroid cancer cell proliferation in vitro and in nude mice...
May 27, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28551819/mir-1271-inhibits-cell-growth-in-prostate-cancer-by-targeting-erg
#6
Miao Wang, Wei Gao, Dehong Lu, Lianghong Teng
ETS-related gene (ERG) is an oncogene that is commonly found in prostate cancer (PCa). Several miRNAs have been reported to be associated with PCa. This study was undertaken to identify miRNAs that act as a tumor suppressor by targeting ERG. We collected 70 PCa and paired adjacent non-tumor (Adjacent-N) tissues and analyzed ERG expression by immunohistochemistry(IHC). Expression of 6 miRNAs (miR-21,-34a,-96,-125b,-150 and miR-1271) was analyzed by qRT-PCR. Luciferase reporter assay was performed to examine miRNA binding to the 3'-UTR of target genes...
May 27, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28551813/cd45ra-foxp3-high-regulatory-t-cells-have-a-negative-impact-on-the-clinical-outcome-of-head-and-neck-squamous-cell-carcinoma
#7
Fumie Ihara, Daiju Sakurai, Atsushi Horinaka, Yuji Makita, Akira Fujikawa, Toshioki Sakurai, Kazuki Yamasaki, Naoki Kunii, Shinichiro Motohashi, Toshinori Nakayama, Yoshitaka Okamoto
BACKGROUND: Although regulatory T cells (Tregs) are thought to play an important role in immune suppression, their clinical significance in head and neck squamous cell carcinoma (HNSCC) is unclear. A recent study reported Tregs could be divided into functional subsets based on the expression of CD45RA and Foxp3. METHOD: The frequency of circulating Treg subsets was analyzed in patients with HNSCC and compared with the frequency in patients with benign tumors. The association of Treg subsets with the frequency of lymphocyte subsets, status of progression, clinical course, and prognosis were also examined...
May 27, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28551767/does-rarity-mean-imparity-biological-characteristics-of-osteosarcoma-cells-originating-from-the-spine
#8
Zhenhua Zhou, Yan Li, Xu Yan, Xudong Wang, Cheng Yang, Haifeng Wei, Xinghai Yang, Jianru Xiao
PURPOSE: Osteosarcoma is one of the most common malignancies in bones and is often found in limbs. Until now, it is not clear why osteosarcoma is rare in the spine. On the other hand, previous biological characteristics study about osteosarcoma of spine was also rare because of its low incidence. To explore the biology of spinal osteosarcoma, a stable osteosarcoma cell line derived from spine is necessary. METHODS: A novel osteosarcoma cell line named NEO217 was established from spinal osteosarcoma tissues obtained from a Chinese male patient...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28551766/axl-gas6-expression-can-predict-for-adverse-prognosis-in-non-small-cell-lung-cancer-with-brain-metastases
#9
Xiaoliang Wu, Wenjuan Ma, Qianghua Zhou, Haijuan Yan, Zuan-Fu Lim, Mayan Huang, Chuangzhong Deng, Xingsu Yu, Huifang Su, Satoshi Komo, Haixia Yang, Xinke Zhang, Sijin Wen, Zhenfeng Zhang, Patrick C Ma
PURPOSE: Patients with non-small cell lung cancer (NSCLC) brain metastases (BM) have poor clinical outcomes. We sought to determine if AXL-GAS6 expression can be used as independent prognostic biomarkers for NSCLC BM. METHODS: We retrospectively studied the medical records of 98 patients diagnosed with advanced metastatic NSCLC from December 2000 to June 2014. Out of a total of 98 patients with NSCLC metastases, 66 patients were identified to have brain metastases...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28551720/effect-of-paricalcitol-on-pancreatic-oxidative-stress-inflammatory-markers-and-glycemic-status-in-diabetic-rats
#10
T M Ali, B El Esawy, A Elaskary
OBJECTIVES: This study is designed to explore the effect of paricalcitol (vitamin D receptor agonist) on pancreatic oxidative stress, inflammatory markers, and adiponectin and glycemic status in diabetic rats. MATERIALS AND METHODS: Forty Sprague-Dawley male rats aged 10-12 weeks (150-250 g) were used in this study. Type 2 diabetes was developed by providing 4 weeks of high-fat-diet feeding before one shot of streptozotocin injection (40 mg/kg i.p.). Four study groups were designed as normal control rats, diabetic control vehicle-treated, diabetic paricalcitol-treated (0...
May 27, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28551685/concordance-of-her2-immunohistochemistry-and-fluorescence-in-situ-hybridization-using-tissue-microarray-in-breast-cancer
#11
Daniela Furrer, Simon Jacob, Chantal Caron, François Sanschagrin, Louise Provencher, Caroline Diorio
AIM: Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are common methods for assessment of human epidermal growth factor receptor 2 (HER2) in breast cancer. MATERIALS AND METHODS: In a cohort of 498 consecutive patients with breast cancer, we examined concordance between IHC and FISH for HER2 on tissue microarray (TMA) sections. In a subset of 116 specimens, we examined HER2 concordance from the block used for diagnostics and a randomly-chosen additional block (a proxy of the core biopsy)...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551683/jc-virus-and-lung-adenocarcinoma-fact-or-myth
#12
Emanuele Sinagra, Dario Raimondo, Elena Gallo, Mario Stella, Mario Cottone, Francesca Rossi, Marco Messina, Massimiliano Spada, Giovanni Tomasello, Giuseppe Ferrara, Aroldo Gabriele Rizzo
BACKGROUND/AIM: An association has been reported between lung cancer and John Cunningham (JC) virus infection. The aim of this study was to evaluate the prevalence of JC virus in a small cohort of patients with lung adenocarcinoma and assess its presence in nodal metastasis. MATERIALS AND METHODS: Consecutive samples of 13 surgically-removed lung tumors and 13 surrounding normal cancer-free tissues were selected. Five cases included metastatic lymph nodes. JC virus infection was assessed through nested PCR...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551677/serum-levels-of-igf-1-and-igfbp-3-in-relation-to-clinical-and-pathobiological-aspects-of-head-and-neck-squamous-cell-carcinomas
#13
David Kalfert, Marie Ludvikova, Ondrej Topolcan, Petr Celakovsky, Radek Kucera, Jindra Windrichova, Jaroslav Ludvik, Katerina Skalova, Vlastimil Kulda, Martin Pesta, Jan Plzak
BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. PATIENTS AND METHODS: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551675/urinary-tract-resections-in-advanced-stage-cervical-cancer-a-series-of-eight-cases
#14
Dana Nuti Oprescu, Nicolae Bacalbasa, Irina Balescu, Alexandru Filipescu
BACKGROUND/AIM: Cervical cancer is one of the most frequent malignancies in women worldwide and is unfortunately diagnosed in advanced stages of the disease. Whenever local invasion is present, neoadjuvant therapy might be needed in order to limit the degree of local invasion. However, in certain cases local invasion persists even after completing the neoadjuvant radiochemotherapy; in these patients more extensive resections might be needed in order to achieve a radical resection. PATIENTS AND METHODS: We present a case series of eight patients in whom segmental ureteral or uretero-vesical resections were performed as part of the radical resections for locally advanced cervical tumors...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551673/tissue-factor-expression-does-not-predict-mortality-in-breast-cancer-patients
#15
Simon F Stämpfli, Alexander Akhmedov, Silke Hausladen, Zsuzsanna Varga, Konstantin J Dedes, Jens Hellermann, Thomas F Lüscher, Glen Kristiansen, Felix C Tanner, Alexander Breitenstein
BACKGROUND: Tissue factor (TF), the trigger of coagulation, not only initiates thrombus formation, but also elicits tumor growth and invasion in breast cancer. However, the characterization of TF expression in breast cancer tissue and its prognostic value remain unclear. MATERIALS AND METHODS: Three hundred and three primary breast cancer specimens from the local tumor tissue database were immunostained for TF expression and evaluated semiquantitatively. Tumor characteristics (size, grade, nodal status, and ER expression) as well as patient's survival were assessed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551672/ctnnb1-mutations-in-ovarian-microcystic-stromal-tumors-identification-of-a-novel-deletion-mutation-and-the-use-of-pyrosequencing-to-identify-reported-point-mutation
#16
Kiyong Na, Eun Kyung Kim, Wonjun Jang, Hyun-Soo Kim
BACKGROUND/AIM: Microcystic stromal tumor (MCST) is a rare stromal tumor of the ovary. In this study, we describe clinicopathological characteristics and results of mutational analyses of the CTNNB1gene in two cases of ovarian MCST and we provide a thorough review of previously published cases alongside our current cases and clarify the clinicopathological characteristics of ovarian MCST. PATIENTS AND METHODS: Patients' age was 33 and 31 years, respectively. One patient presented with fever and low abdominal pain, whereas a pelvic mass was incidentally detected in another patient...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551667/duration-of-preoperative-biliary-drainage-as-a-prognostic-factor-after-pancreaticoduodenectomy-for-pancreatic-head-cancer
#17
Michinori Matsumoto, Yukio Nakabayashi, Yuki Fujiwara, Naotake Funamizu, Rota Noaki, Seiichiro Eto, Hiroshi Sugano, Masahiko Otsuka, Katsuhiko Yanaga
BACKGROUND/AIM: Preoperative biliary drainage (PBD) is often performed for jaundiced patients. However, the optimal duration of PBD remains unknown. The aim of this study was to investigate whether duration of PBD influenced the prognosis of patients after pancreaticoduodenectomy (PD) for pancreatic head cancer. PATIENTS AND METHODS: Twenty-five patients who underwent PD for pancreatic head cancer with obstructive jaundice between 2007 and 2013 were included. Tumor and host factors were analyzed to evaluate their potential prognostic effects and patients' characteristics between the two groups according to the duration of PBD were analyzed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551658/preoperative-ca-125-values-as-a-predictive-factor-for-the-postoperative-outcome-in-primary-serous-ovarian-cancer
#18
Mustafa Zelal Muallem, Asya Parashkevova, Jumana Almuheimid, Rolf Richter, Yasser Diab, Elena Ioana Braicu, Jalid Sehouli
BACKGROUND/AIM: The purpose of the study was to examine the preoperative CA-125 values as a predictive factor for postoperative outcome in primary serous ovarian cancer (POC) for complete tumor resection (CTR) and evaluate the preoperative CA-125 levels with other vital clinical dynamics such as ascites, lymph node involvement, diffuse peritoneal carcinomatosis, grading and staging. PATIENTS AND METHODS: A cohort of 277 POC-patients aged 18-75 years, who had undergone primary cytoreductive surgery at the Department of Gynecology & Oncological Surgery, Charité, Campus Virchow Klinikum (CVK) between 2000 und 2009 was analyzed in correlation with the preoperative CA-125 values...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551654/overexpression-of-egfr-as-an-independent-prognostic-factor-in-adenocarcinoma-of-the-esophagogastric-junction
#19
Kenichi Aratani, Shuhei Komatsu, Daisuke Ichikawa, Takuma Ohashi, Mahito Miyamae, Wataru Okajima, Taisuke Imamura, Jun Kiuchi, Keiji Nishibeppu, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Kazuma Okamoto, Hitoshi Tsuda, Eigo Otsuji
BACKGROUND: Adenocarcinoma of the esophagogastric junction (AEG) has increased in Western and Eastern countries, and its prognosis remains poor. We tested whether epidermal growth factor receptor (EGFR), that is overexpressed in various tumors, acts as a cancer-promoting gene through overexpression in AEG. MATERIALS AND METHODS: We analyzed 104 primary AEG tumors which were curatively resected in our hospital between 2000 and 2010. RESULTS: Overexpression of EGFR protein was detected in 47% primary AEG tumor samples, and significantly associated with venous and lymphatic invasion, tumor depth and lymph node metastasis...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551653/clinical-relevance-of-serum-her2-and-circulating-tumor-cell-detection-in-metastatic-breast-cancer-patients
#20
Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter Andreas Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm, Volkmar Müller
BACKGROUND/AIM: Presence of circulating tumor cells (CTCs) is associated with impaired survival in metastatic breast cancer (MBC). This study was designed to evaluate whether assessment of serum HER2 (sHER2) levels provide additional prognostic information in MBC. MATERIALS AND METHODS: Two hundred and fifty-three MBC patients were enrolled in this multicentre trial. CTCs were detected before the start of first- or later-line treatment using the CellSearch system...
June 2017: Anticancer Research
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