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https://www.readbyqxmd.com/read/29793198/assessment-of-cu-sub-lethal-toxicity-lc-50-in-the-cold-water-gorgonian-dentomuricea-meteor-under-a-deep-sea-mining-activity-scenario
#1
Inês Martins, António Godinho, Joana Goulart, Marina Carreiro-Silva
Previous aquaria-based experiments have shown dissolution and leaching of metals, especially copper (Cu), from the simulated sediment plumes generated during mining activities resulting in a pronounced increase of Cu contamination in the surrounding seawater. Metals are bioavailable to corals with food, through ingestion (particulate phase) and through tissue-facilitated transport (passive diffusion). With corals being particularly vulnerable to metal contamination, resuspension of metal-bearing sediments during mining activities represents an important ecological threat...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29792955/fisetin-alleviates-oxidative-stress-after-traumatic-brain-injury-via-the-nrf2-are-pathway
#2
Li Zhang, Handong Wang, Yali Zhou, Yihao Zhu, Maoxin Fei
Fisetin, a natural flavonoid, has neuroprotection properties in many brain injury models. However, its role in traumatic brain injury (TBI) has not been fully explained. In the present study, we aimed to explore the neuroprotective effects of fisetin in a mouse model of TBI. We found that fisetin improved neurological function, reduced cerebral edema, attenuated brain lesion and ameliorated blood-brain barrier (BBB) disruption after TBI. Moreover, the up-regulation of malondialdehyde (MDA) and the activity of glutathione peroxidase (GPx) were reversed by fisetin treatment...
May 21, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29792428/structures-and-activities-of-tiahuramides-a-c-cyclic-depsipeptides-from-a-tahitian-collection-of-the-marine-cyanobacterium-lyngbya-majuscula
#3
Annabel Levert, Rebeca Alvariño, Louis Bornancin, Eliane Abou Mansour, Adam M Burja, Anne-Marie Genevière, Isabelle Bonnard, Eva Alonso, Luis Botana, Bernard Banaigs
The structures of three new cyclic depsipeptides, tiahuramides A (1), B (2), and C (3), from a French Polynesian collection of the marine cyanobacterium Lyngbya majuscula are described. The planar structures of these compounds were established by a combination of mass spectrometry and 1D and 2D NMR experiments. Absolute configurations of natural and nonproteinogenic amino acids were determined through a combination of acid hydrolysis, derivitization with Marfey's reagent, and HPLC. The absolute configuration of hydroxy acids was confirmed by Mosher's method...
May 24, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29792358/in-vitro-activities-of-ceiba-speciosa-a-st-hil-ravenna-aqueous-stem-bark-extract
#4
Juliana Andréa Dörr, Shanna Bitencourt, Luísa Bortoluzzi, Celso Alves, Joana Silva, Stefani Stoll, Susete Pinteus, Aline Augusti Boligon, Roberto Christ Vianna Santos, Stefan Laufer, Rui Pedrosa, Márcia Inês Goettert
Several species of the genus Ceiba (Malvaceae) are ethnopharmacologically used. Thus, this study aimed to investigate the in vitro beneficial properties of the aqueous stem bark extract of Ceiba speciosa. The extract presented a great amount of phenolic compounds (117.4 ± 6.2 mg GAE/g). The antioxidant activity was assessed by DPPH (IC50  = 42.87 μg/mL), ORAC (2351.17 μmol TE/g) and FRAP (235.94 μM FeSO4 /g) methods. In addition, the extract reduced MCF-7 cell viability as assessed by MTT. However, it prevented mitochondrial membrane depolarization and reduced caspase-9 activity induced by hydrogen peroxide...
May 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29791982/-management-of-intrahepatic-duct-stone
#5
REVIEW
Sang Woo Cha
Intrahepatic duct (IHD) stone is the presence of calculi within the intrahepatic bile duct specifically located proximal to the confluence of the left and right hepatic ducts. This stone is characterized by its intractable nature and frequent recurrence, requiring multiple therapeutic interventions. Without proper treatment, biliary strictures and retained stones can lead to repeated episodes of cholangitis, liver abscesses, secondary biliary cirrhosis, portal hypertension, and death from sepsis or hepatic failure...
May 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29791306/cause-of-caregiver-death-and-surviving-caregiver-coping-style-predict-thwarted-belongingness-in-bereaved-youth
#6
Michelle E Roley-Roberts, Ryan M Hill, Christopher M Layne, Hayley Goldenthal, Julie B Kaplow
OBJECTIVES: Both bereavement and thwarted belongingness serve as risk markers for youth suicide-related behaviors. This study examined candidate predictors of thwarted belongingness among bereaved youth, including caregiver cause of death and surviving caregiver coping style. METHODS: Forty-three caregiver-bereaved families (58 children aged 7-13 years old) participated in a longitudinal study investigating associations between hypothesized bereavement-related contextual factors and youth thwarted belongingness...
May 23, 2018: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29791266/building-castles-made-of-pleasure
#7
David Zachary Hafner
To outlive the suicide of one's beloved, an ineffable trauma, entails a complicated grieving process. This paper illustrates the importance of understanding body and self as malleable, invested objects. The treatment of traumatized patients involves redrawing body frontiers, and subsequent reassurance that the body, once delineated and inhabited, won't betray its host. The concepts of objet a and transitional objects help distinguish anxieties related to external loss from anxieties related to the incorporation or reabsorption of an object whose cruel proximity threatens the internal integrity of body experience...
June 2018: Psychoanalytic Review
https://www.readbyqxmd.com/read/29791030/antiepileptic-drugs-as-prophylaxis-for-postcraniotomy-seizures
#8
REVIEW
Janette Greenhalgh, Jennifer Weston, Yenal Dundar, Sarah J Nevitt, Anthony G Marson
BACKGROUND: This is an updated version of the Cochrane Review previously published in Issue 3, 2015.The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure appears to vary from 3% to 92% over a five-year period. Postoperative seizures can precipitate the development of epilepsy; seizures are most likely to occur within the first month of cranial surgery. The use of antiepileptic drugs (AEDs) administered pre- or postoperatively to prevent seizures following cranial surgery has been investigated in a number of randomised controlled trials (RCTs)...
May 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29788870/small-molecules-as-drugs-to-upregulate-metastasis-suppressors-in-cancer-cells
#9
Ka Ming Wong, Jiaxing Song, Vasu Saini, Yung H Wong
It is well-recognized that the majority of cancer-related deaths are attributed to metastasis, which can arise from virtually any type of tumor. Metastasis is a complex multistep process wherein cancer cells must break away from the primary tumor, intravasate into the circulatory or lymphatic systems, extravasate, proliferate and eventually colonize secondary sites. Since these molecular processes involve the coordinated actions of numerous proteins, targeted disruptions of key players along these pathways represent possible therapeutic interventions to impede metastasis formation and reduce cancer mortality...
May 21, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29788005/morphological-identification-of-hair-recovered-from-feces-for-detection-of-cannibalism-in-eastern-chimpanzees
#10
Christopher S Walker, Kara K Walker, Gabo Paulo, Anne E Pusey
Chimpanzees (Pan troglodytes) are primarily frugivorous but consume a variable amount of meat from a variety of organisms, including other chimpanzees. Cannibalism is rare, usually follows lethal aggression, and does not occur following natural deaths. While chimpanzee cannibalism has been documented at multiple sites, many instances of this behavior go unrecorded. Identification of chimpanzee remains in feces, however, can provide indirect evidence of cannibalism. Hair, in particular, typically passes through the gastrointestinal tract undamaged and is commonly used for purposes of identification in wildlife forensics...
May 22, 2018: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/29787814/lipid-modified-cell-penetrating-peptide-based-self-assembly-micelles-for-co-delivery-of-narciclasine-and-siulk1-in-hepatocellular-carcinoma-therapy
#11
Xiaoyun Wang, Fengbo Wu, Guoyou Li, Nan Zhang, Xiangrong Song, Yu Zheng, Changyang Gong, Bo Han, Gu He
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer, and one therapeutic approach is to target both the AMPK and autophagy pathways in order to synergistically promote programmed cell death. Here, a series of amphiphilic, lipid-modified cell-penetrating peptides were synthesized and allowed to self-assemble into micelles loaded with the AMPK activator narciclasine (Narc) and short interfering RNA targeting the unc-51-like kinase 1 (siULK1). The size of these micelles, their efficiency of transfection into cells, and their ability to release drug or siRNA cargo in vitro were pH-sensitive, such that drug release was facilitated in the acidic microenvironment of the tumor...
May 19, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29787574/child-morbidity-and-mortality-associated-with-alternative-policy-responses-to-the-economic-crisis-in-brazil-a-nationwide-microsimulation-study
#12
Davide Rasella, Sanjay Basu, Thomas Hone, Romulo Paes-Sousa, Carlos Octávio Ocké-Reis, Christopher Millett
BACKGROUND: Since 2015, a major economic crisis in Brazil has led to increasing poverty and the implementation of long-term fiscal austerity measures that will substantially reduce expenditure on social welfare programmes as a percentage of the country's GDP over the next 20 years. The Bolsa Família Programme (BFP)-one of the largest conditional cash transfer programmes in the world-and the nationwide primary healthcare strategy (Estratégia Saúde da Família [ESF]) are affected by fiscal austerity, despite being among the policy interventions with the strongest estimated impact on child mortality in the country...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29785122/aloperine-executes-antitumor-effects-through-the-induction-of-apoptosis-and-cell-cycle-arrest-in-prostate-cancer-in-vitro-and-in-vivo
#13
Zhixin Ling, Han Guan, Zonghao You, Can Wang, Ling Hu, Lei Zhang, Yiduo Wang, Shuqiu Chen, Bin Xu, Ming Chen
Background: Prostate cancer (PCa) is one of the most common malignant diseases among male patients. Although androgen deprivation therapy remains the main treatment for PCa, most patients would inevitably progress to castration-resistant PCa, which is the main cause of cancer-related deaths. Thus, novel antitumor agents are urgently needed. Recent studies demonstrated that aloperine (ALO) as a natural alkaloid showed antitumor effects in other cancer types. However, the biological function and underlying mechanisms of ALO in PCa have not been investigated...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29784141/psychosocial-care-from-the-perspective-of-nurses-working-in-oncology-a-qualitative-study
#14
Perihan Güner, Duygu Hiçdurmaz, Nazmiye Kocaman Yıldırım, Figen İnci
PURPOSE: In cancer patients, unmet psychosocial needs are a common occurrence. The purpose of this study was to determine the views, obstacles, and needs of the nurses working with adult oncology patients with regards to psychosocial care. METHODS: A qualitative descriptive research design conducted through focus group interviews was adopted for the study. Thirty nurses providing care for cancer patients in adult oncology departments of three hospitals in Turkey with comprehensive oncology centers were involved in the interviews...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29783017/the-hydro-ethanolic-extract-of-acacia-seyal-mimosaceae-stem-barks-induced-death-in-an-er-negative-breast-cancer-cell-line-by-the-intrinsic-pathway-of-apoptosis-and-inhibited-cell-migration
#15
Stephane Zingue, Thomas Michel, Julia Cisilotto, Alain Brice Tueche, Derek Tantoh Ndinteh, Leônidas João Mello, Dieudonné Njamen, Tânia Beatriz Creczynski-Pasa
BACKGROUND: Despite the significant developments occurring in the treatment of cancer, it still remains the second deadly disease, responsible for 8.2 million deaths every year. Various natural substances have been studied for active molecules of tumor suppression in the past and the tropical flora, by its diversity, continues to provide new antitumor drugs. Acacia seyal is a plant used in Cameroonian traditional system to treat cancer. It exhibited cytotoxic effects towards human breast adenocarcinoma cells...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29782951/clinical-consequences-of-toxic-envenomations-by-hymenoptera
#16
Justin O Schmidt
Many familiar Hymenoptera are brightly colored and can sting painfully-thus, their threat and clinical importance may be exaggerated. Most stinging insects only sting to defend themselves or their colonies from predators. The clinical nature of Hymenoptera envenomations contrasts that of other venomous animals, including other arthropods, primarily because allergic reaction, not direct intoxication, is the usual main concern. This review focuses mainly on the clinical features of direct toxicity to Hymenoptera envenomations, which can induce a high incidence of acute renal failure, liver failure, multiple organ failures, and death...
May 18, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29782186/excessive-erythrocytosis-and-cardiovascular-risk-in-andean-highlanders
#17
Noemí Corante, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L Gamboa, Fabiola León-Velarde, Francisco C Villafuerte
Cardiovascular diseases are the main cause of death worldwide. Life under high-altitude (HA) hypoxic conditions is believed to provide highlanders with a natural protection against cardiovascular and metabolic diseases compared with sea-level inhabitants. However, some HA dwellers become intolerant to chronic hypoxia and develop a progressive incapacitating syndrome known as chronic mountain sickness (CMS), characterized by excessive erythrocytosis (EE; Hb ≥21 g/dL in men, Hb ≥19 g/dL in women). Evidence from HA studies suggests that, in addition to CMS typical signs and symptoms, these highlanders may also suffer from metabolic and cardiovascular disorders...
May 21, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29781250/low-level-aflatoxin-exposure-associated-with-greater-linear-growth-in-southern-mexico-a-longitudinal-study
#18
Jef L Leroy, Celeste Sununtnasuk, Armando García-Guerra, Jia-Sheng Wang
Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk-based multiple micronutrient-fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder...
May 21, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29781242/photo-controlled-reversible-microtubule-assembly-mediated-by-cyclodextrin-derivative
#19
Ying-Ming Zhang, Ni-Yuan Zhang, Kui Xiao, Yu Liu, Qilin Yu
The design and construction of multistimuli-responsive supramolecular nanoassemblies that can mimic and regulate the fundamental biological processes has become a focus of interest in supramolecular chemistry. In this work, a perfect combination has been achieved between naturally occurring microtubule and artificially macrocyclic receptor. The self-assembling morphology of microtubules can be photo-tuned by the host-guest interaction of paclitaxel-modified β-cyclodextrin (PTX-CD) and photochromic arylazopyrazole (PTX-AAP)...
May 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29780393/immunomodulatory-drugs-exert-anti-leukemia-effects-in-acute-myeloid-leukemia-by-direct-and-immunostimulatory-activities
#20
Aude Le Roy, Thomas Prébet, Rémy Castellano, Armelle Goubard, Florence Riccardi, Cyril Fauriat, Samuel Granjeaud, Audrey Benyamine, Céline Castanier, Florence Orlanducci, Amira Ben Amara, Frédéric Pont, Jean-Jacques Fournié, Yves Collette, Jean-Louis Mege, Norbert Vey, Daniel Olive
Immunomodulatory drugs (IMiDs) are anticancer drugs with immunomodulatory, anti-angiogenesis, anti-proliferative, and pro-apoptotic properties. IMiDs are currently used for the treatment of multiple myeloma, myelodysplastic syndrome, and B-cell lymphoma; however, little is known about efficacy in acute myeloid leukemia (AML). We proposed in this study to investigate the relevance of IMiDs therapy for AML treatment. We evaluated the effect of IMiDs on primary AML blasts ( n  = 24), and the impact in natural killer (NK) cell-mediated immunosurveillance of AML...
2018: Frontiers in Immunology
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