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https://www.readbyqxmd.com/read/28650359/outcomes-of-concurrent-operations-results-from-the-american-college-of-surgeons-national-surgical-quality-improvement-program
#1
Jason B Liu, Julia R Berian, Kristen A Ban, Yaoming Liu, Mark E Cohen, Peter Angelos, Jeffrey B Matthews, David B Hoyt, Bruce L Hall, Clifford Y Ko
OBJECTIVE: To determine whether concurrently performed operations are associated with an increased risk for adverse events. BACKGROUND: Concurrent operations occur when a surgeon is simultaneously responsible for critical portions of 2 or more operations. How this practice affects patient outcomes is unknown. METHODS: Using American College of Surgeons' National Surgical Quality Improvement Program data from 2014 to 2015, operations were considered concurrent if they overlapped by ≥60 minutes or in their entirety...
June 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28650116/polymeric-drug-delivery-systems-for-intraoral-site-specific-chemoprevention-of-oral-cancer
#2
REVIEW
Kashappa Goud H Desai
Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery...
June 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28649561/psd1-effects-on-candida-albicans-planktonic-cells-and-biofilms
#3
Sónia Gonçalves, Patrícia M Silva, Mário R Felício, Luciano N de Medeiros, Eleonora Kurtenbach, Nuno C Santos
Candida albicans is an important human pathogen, causing opportunistic infections. The adhesion of planktonic cells to a substrate is the first step for biofilm development. The antimicrobial peptide (AMP) Psd1 is a defensin isolated from Pisum sativum seeds. We tested the effects of this AMP on C. albicans biofilms and planktonic cells, comparing its activity with amphotericin B and fluconazole. Three C. albicans variants were studied, one of them a mutant deficient in glucosylceramide synthase, conferring resistance to Psd1 antifungal action...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28649089/prognostic-nutritional-index-and-the-risk-of-mortality-in-patients-with-acute-heart-failure
#4
Yu-Lun Cheng, Shih-Hsien Sung, Hao-Min Cheng, Pai-Feng Hsu, Chao-Yu Guo, Wen-Chung Yu, Chen-Huan Chen
BACKGROUND: Nutritional status has been related to clinical outcomes in patients with heart failure. We assessed the association between nutritional status, indexed by prognostic nutritional index (PNI), and survival in patients hospitalized for acute heart failure. METHODS AND RESULTS: A total of 1673 patients (age 76±13 years, 68% men) hospitalized for acute heart failure in a tertiary medical center were analyzed. PNI was calculated as 10×serum albumin (g/dL)+0...
June 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28648922/oxovanadium-iv-complexes-with-knoevenagel-schiff-base-condensate-as-impending-chemotherapeutic-agents-synthesis-characterization-biological-screening-and-anti-proliferative-assay
#5
Rajakkani Paulpandiyan, Natarajan Raman
Two novel oxovanadium(IV) complexes [VOL1]SO4(1) and [VOL2]SO4(2) containing Knoevenagel condensate Schiff base ligand (L1/L2) have been synthesized and characterized by physical, spectral and analytical methods. These complexes are reported as ionic in nature on the basis of elemental composition and molar conductance, and possess square pyramidal geometry around the central metal ions. The binding interactions of (1) and (2) with calf thymus DNA (CT DNA) were explored by absorption spectrophotometric titration, cyclic voltammetry data and viscosity measurements...
June 19, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28648866/cytokines-in-immunogenic-cell-death-applications-for-cancer-immunotherapy
#6
REVIEW
Anne Showalter, Arati Limaye, Jeremiah L Oyer, Robert Igarashi, Christina Kittipatarin, Alicja J Copik, Annette R Khaled
Despite advances in treatments like chemotherapy and radiotherapy, metastatic cancer remains a leading cause of death for cancer patients. While many chemotherapeutic agents can efficiently eliminate cancer cells, long-term protection against cancer is not achieved and many patients experience cancer recurrence. Mobilizing and stimulating the immune system against tumor cells is one of the most effective ways to protect against cancers that recur and/or metastasize. Activated tumor specific cytotoxic T lymphocytes (CTLs) can seek out and destroy metastatic tumor cells and reduce tumor lesions...
June 22, 2017: Cytokine
https://www.readbyqxmd.com/read/28648403/genetic-determinant-of-bacillus-pumilus-lipase-lethality-and-its-application-as-positive-selection-cloning-vector-in-escherichia-coli
#7
Nobalanda Betty Mabizela-Mokoena, Shonisani Wendy Limani, Ignatious Ncube, Lizelle Piater, Derek Litthauer, Mulalo Bethuel Nthangeni
Positive selection vectors carry genes that upon expression produce proteins that cause host cell deaths. Insertion of foreign DNA fragments within the ORF of the gene disrupts the lethal effect of the expressed protein. This study described the cloning of Family I.4 Bacillus pumilus lipase gene whose expressed protein is toxic and lethal to Escherichia coli JM109 (DE3) cells. The determinant of toxicity was identified through Error-prone PCR to be the nature of amino acid residue resident at position 28 of the mature lipase protein...
June 22, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28646954/development-of-respiratory-syncytial-virus-rsv-vaccines-for-infants
#8
Hannah E Gerretsen, Charles J Sande
2017 will mark the 60(th) anniversary since the first isolation of RSV in children. In spite of concerted efforts over all these years, the goal of developing an effective vaccine against paediatric RSV disease has remained elusive. One of the main hurdles standing in the way of an effective vaccine is the fact that the age incidence of severe disease peaks within the first 3 months of life, providing limited opportunity for intervention. In addition to this complexity, the spectre of failed historical vaccines, which increased the risk of illness and death upon subsequent natural infection, has substantially increased the safety criteria against which modern vaccines will be assessed...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28646756/protein-functionalization-of-zno-nanostructure-exhibits-selective-and-enhanced-toxicity-to-breast-cancer-cells-through-oxidative-stress-based-cell-death-mechanism
#9
Sailendra Mahanta, S Prathap, Deependra Kumar Ban, Subhankar Paul
Zinc oxide nanostructure (ZnONS) was chemically synthesized and functionalized (FZnONSBLA) with a small protein bovine α-lactalbumin (BLA) by chemical cross-linking methods. Both nano-structures were characterized using various techniques such as electron microscopy, dynamic light scattering (DLS), UV-Vis spectroscopy, FT-IR, photo-luminescence and X-ray diffraction. Electron microscopy and DLS analysis revealed their (ZnONS and FZnONSBLA) average size of 200nm and 450nm, respectively. When cytotoxicity of both the nanostructures were assessed in breast cancer cells MCF-7 and MDAMB231 by MTT assay and PI/Annexin V staining (FACS), FZnONSBLA demonstrated higher cell death than ZnONS primarily due to generation of intracellular reactive oxygen species (ROS)...
June 15, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28646710/psychological-distress-and-the-incident-risk-of-functional-disability-in-elderly-survivors-after-the-great-east-japan-earthquake
#10
Fumiya Tanji, Yumi Sugawara, Yasutake Tomata, Takashi Watanabe, Kemmyo Sugiyama, Yu Kaiho, Hiroaki Tomita, Ichiro Tsuji
BACKGROUND: We conducted a prospective cohort study to investigate whether psychological distress would have increased the incident risk of functional disability after the 2011 Great East Japan Earthquake. METHODS: First phase data pertaining to psychological distress and other lifestyle factors were collected from 1037 subjects aged ≥ 65 years, from June to December 2011, in four affected areas of Miyagi prefecture in Japan. Psychological distress was measured by the Kessler 6-item psychological distress scale (K6), and classified into three categories (K6 score ≤ 9, 10-12, ≥ 13)...
June 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28645945/how-can-we-ensure-that-the-coroner-s-autopsy-is-not-an-invasion-of-human-rights
#11
Stephen Leadbeatter, Ryk James
BACKGROUND: Despite public inquiries, and some changes to legislation following high-profile multiple homicides that were not detected by autopsy, coroners continue to rely largely on the autopsy. Regardless of the extent of quality failings and excess deaths at some hospitals, not detected through the coroner system, the autopsy is scarcely used by hospitals to monitor standards and educate. OBJECTIVE: To explore when a compulsory medicolegal autopsy should, and should not, be used...
June 23, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28645888/hiv-strategic-information-in-non-european-union-countries-in-the-world-health-organization-european-region-capacity-development-needs
#12
Ivana Bozicevic, Senad Handanagic, Jurja Ivana Cakalo, Annemarie Rinder Stengaard, George Rutherford
BACKGROUND: Capacity building of the national HIV strategic information system is a core component of the response to the HIV epidemic as it enables understanding of the evolving nature of the epidemic, which is critical for program planning and identification of the gaps and deficiencies in HIV programs. OBJECTIVE: The study aims to describe the results of the assessment of the needs for further development of capacities in HIV strategic information systems in the non-European Union (EU) countries in the World Health Organization European Region (EUR)...
June 23, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28645422/form-of-presentation-natural-history-and-course-of-postoperative-venous-thromboembolism-in-patients-operated-on-for-pelvic-and-abdominal-cancer-analysis-of-the-riete-registry
#13
Ana Belén Bustos Merlo, Juan Ignacio Arcelus Martínez, Jesús Damián Turiño Luque, Beatriz Valero, Aurora Villalobos, Miguel Ángel Aibar, Manuel Monreal Bosch
INTRODUCTION: Venous thromboembolism (VTE) represents a serious complication after oncologic surgery. Recent studies have shown that the risk of VTE persists several weeks after surgery. This study assesses the form of presentation and time course of VTE after abdominal and pelvic cancer surgery. METHODS: Prospective, multicenter, observational study that analyzes data from an international registry (RIETE) that includes consecutive patients with symptomatic VTE...
June 20, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28644057/the-implementation-of-medical-monitoring-programs-following-potentially-hazardous-exposures-a-medico-legal-perspective
#14
David Vearrier, Michael I Greenberg
CONTEXT: Clinical toxicologists may be called upon to determine the appropriateness of medical monitoring following documented or purported exposures to toxicants in the occupational, environmental, and medical settings. METHODS: We searched the MEDLINE database using the Ovid(®) search engine for the following terms cross-referenced to the MeSH database: ("occupational exposures" OR "environmental exposures") AND ("physiologic monitoring" OR "population surveillance")...
June 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28643197/ampk-is-activated-early-in-cerebellar-granule-cells-undergoing-apoptosis-and-influences-vadc1-phosphorylation-status-and-activity
#15
A Bobba, E Casalino, G Amadoro, V A Petragallo, A Atlante
The neurodegeneration of cerebellar granule cells, after low potassium induced apoptosis, is known to be temporally divided into an early and a late phase. Voltage-dependent anion channel-1 (VDAC1) protein, changing from the closed inactive state to the active open state, is central to the switch between the early and late phase. It is also known that: (i) VDAC1 can undergo phosphorylation events and (ii) AMP-activated protein kinase (AMPK), the sensor of cellular stress, may have a role in neuronal homeostasis...
June 22, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28641544/post-mortem-redistribution-of-drugs-current-state-of-knowledge
#16
Caroline Sastre, Christophe Bartoli, Valerie Baillif-Couniou, Georges Leonetti, Anne-Laure Pelissier-Alicot
BACKGROUND: Drug concentrations obtained from post mortem samples do not necessarily reflect the concentrations at the time of death, and variations of concentration may be observed between different sites and/or different sampling times. These phenomena, collectively termed post mortem redistribution, concern numerous molecules (medications, drugs of abuse, gases, etc.) and can complicate the interpretation of toxicological analyses. METHODS: Literature review...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28640689/deciphering-suicide-and-other-manners-of-death-associated-with-drug-intoxication-a-centers-for-disease-control-and-prevention-consultation-meeting-summary
#17
Deborah M Stone, Kristin M Holland, Brad Bartholow, Joseph Logan, Wendy LiKamWa McIntosh, Aimee Trudeau, Ian R H Rockett
Manner of death (MOD) classification (i.e., natural, accident, suicide, homicide, or undetermined cause) affects mortality surveillance and public health research, policy, and practice. Determination of MOD in deaths caused by drug intoxication is challenging, with marked variability across states. The Centers for Disease Control and Prevention hosted a multidisciplinary meeting to discuss drug intoxication deaths as they relate to suicide and other MOD. The meeting objectives were to identify individual-level, system-level, and place-based factors affecting MOD classification and identify potential solutions to classification barriers...
June 22, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28638884/anticancer-activity-of-5-7-dimethoxyflavone-against-liver-cancer-cell-line-hepg2-involves-apoptosis-ros-generation-and-cell-cycle-arrest
#18
Hengping Li, Xiaolei Zhang, Weixing Wang
BACKGROUND: Flavonoids are considered potential anticancer agents owing to their properties to interact with a diversity of cellular entities. Among flavonoids, methylated flavones are more efficient anticancer agents due to their higher stability in vivo. The purpose of the present study was, therefore, to evaluate the anticancer effect of methylated natural flavonoid 5, 7-dimethoxyflavone (5, 7-DMF). MATERIALS AND METHODS: MTT assay was used to determine the anticancer activity and IC50 of 5, -DMF)...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28638575/danon-disease-for-the-cardiologist-case-report-and-review-of-the-literature
#19
Ryan S D'souza, Luisa Mestroni, Matthew R G Taylor
Danon disease is a rare, X-linked dominant genetic disorder that is caused by defects in the lysosome-associated membrane protein 2 (LAMP2) gene. It manifests predominantly in young males with a classic triad of cardiomyopathy, skeletal myopathy, and intellectual disability. Death from cardiac disease is the ultimate cause of demise in many patients if left untreated. Given the rarity of the condition, the natural history is poorly understood. Here, we present a case report on a 14-year-old Hispanic boy with Danon disease, highlighting major clinical events and diagnostic study findings over a six-year period from age of symptom onset to age of death...
March 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28637567/the-impact-of-early-recurrence-on-quality-of-life-after-cytoreduction-with-hipec
#20
Nathan M Hinkle, Vandana Botta, John P Sharpe, Paxton Dickson, Jeremiah Deneve, Gitonga Munene
Improved oncological outcomes after cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in highly selected patients have been well documented. The extensive nature of the procedure adversely affects quality of life (QoL). The aim of this study is to longitudinally evaluate QoL following CRS/HIPEC. This is a retrospective review of a prospectively maintained database of patients with peritoneal malignancies undergoing CRS/HIPEC. Clinicopathological data, oncologic outcomes, and QoL were analyzed preoperatively and postoperatively at 2 weeks, and 1, 3, 6, and 12 months...
June 1, 2017: American Surgeon
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