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https://www.readbyqxmd.com/read/28068448/photorefractive-keratectomy-with-mitomycin-c-in-meesmann-s-epithelial-corneal-dystrophy
#1
Ramon Coral Ghanem, André Luís Piccinini, Vinícius Coral Ghanem
PURPOSE: To describe a case of Meesmann's epithelial corneal dystrophy that underwent photorefractive keratectomy (PRK) with mitomycin C. METHODS: Case report. RESULTS: A 36-year-old woman was evaluated for refractive surgery. She had a history of recurrent epithelial erosions and moderate visual loss over the past 10 years. Biomicroscopy revealed bilateral micro-cystic epithelial lesions and a diagnosis of Meesmann's epithelial corneal dystrophy was proposed...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28060074/eventual-endothelial-failure-after-initial-corneal-clearing-after-a-detached-endothelial-graft-in-fuchs-dystrophy
#2
Hyunjoo J Lee, Wuqaas M Munir
PURPOSE: To report a case of eventual corneal endothelial cell failure after spontaneous resolution of corneal edema after failed Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective case report. RESULTS: A 56-year-old man with Fuchs endothelial corneal dystrophy underwent cataract and DMEK surgery in the left eye. The transplanted DMEK graft detached in the early postoperative period and formed a peripheral scroll. Despite graft detachment, corneal edema resolved with endothelial cell repopulation of the central cornea...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060071/corneal-lenticule-allotransplantation-after-femtosecond-laser-small-incision-lenticule-extraction-in-rabbits
#3
Jing Zhao, Yang Shen, Mi Tian, Ling Sun, Yu Zhao, Xiaoyu Zhang, Xingtao Zhou
PURPOSE: To investigate the feasibility of allotransplanting extracted lenticules after femtosecond laser-assisted small incision lenticule extraction (SMILE) in rabbits and the subsequent healing process. METHODS: Fourteen New Zealand white rabbits were divided evenly into 2 groups. The rabbits in group A received SMILE procedures with a -6.00 D correction. The lenticules from group A were immediately inserted into a femtosecond laser-created corneal stromal pocket in group B...
February 2017: Cornea
https://www.readbyqxmd.com/read/28050730/factors-associated-with-corneal-epithelial-defects-after-pars-plana-vitrectomy
#4
Wei-Yu Chiang, Jong-Jer Lee, Hsi-Kung Kuo, Yi-Hao Chen, Chih-Hsin Chen, Yung-Jen Chen, Pei-Chang Wu, Yun-Wen Chen
PURPOSE: To investigate the risk factors associated with corneal epithelial defects (CED) and delayed healing (exceeding 1 week) following pars plana vitrectomy (PPV). METHODS: This retrospective study enrolled patients who underwent PPV at a single center in Taiwan between 2011 and 2012. Medical records were reviewed, including demographic, underlying disease, surgical indication, operation parameters, and existence of CED. These data were statistically analyzed...
January 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28044425/immediate-effects-of-diamond-burr-debridement-in-patients-with-spontaneous-chronic-corneal-epithelial-defects-light-and-electron-microscopic-evaluation
#5
Charlotte Dawson, Carolina Naranjo, Belen Sanchez-Maldonado, Georgina V Fricker, Rose N Linn-Pearl, Natalia Escanilla, Christiane Kafarnik, David J Gould, Rick F Sanchez, Marian Matas-Riera
PURPOSE: To evaluate immediate effects of diamond burr debridement (DBD) on the cornea of canine patients diagnosed with spontaneous chronic corneal epithelial defects (SCCEDs). ANIMALS STUDIED: Eight client owned dogs with SCCEDs. METHODS: Nine eyes from eight dogs with SCCEDs underwent superficial keratectomy (SK). The ulcerated area was divided into quadrants with a 300-micron restricted depth knife. Two of four quadrants underwent DBD for 40-60 s...
January 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28030558/loss-of-trpv4-function-suppresses-inflammatory-fibrosis-induced-by-alkali-burning-mouse-corneas
#6
Yuka Okada, Kumi Shirai, Masayasu Miyajima, Peter S Reinach, Osamu Yamanaka, Takayoshi Sumioka, Masahide Kokado, Katsuo Tomoyose, Shizuya Saika
In humans suffering from pulmonary disease and a mouse model, transient receptor potential vanilloid 4 (TRPV4) channel activation contributes to fibrosis. As a corneal alkali burn induces the same response, we determined if such an effect is also attributable to TRPV4 activation in mice. Accordingly, we determined if the alkali burn wound healing responses in wild-type (WT) mice are different than those in their TRPV4-null (KO) counterpart. Stromal opacification due to fibrosis in KO (n = 128) mice was markedly reduced after 20 days relative to that in WT (n = 157) mice...
2016: PloS One
https://www.readbyqxmd.com/read/28009531/effect-of-retinol-palmitate-on-corneal-and-conjunctival-mucin-gene-expression-in-a-rat-dry-eye-model-after-injury
#7
Nobuhito Tabuchi, Hiroshi Toshida, Daisuke Koike, Akito Odaka, Chikako Suto, Toshihiko Ohta, Akira Murakami
PURPOSE: We examined the wound-healing effect of retinol palmitate (VApal) on mucin gene and protein expressions in a rat dry eye model based on lacrimal gland (LG) resection after injury. METHODS: The rat dry eye model was prepared by surgical resection of the main LG in male Long-Evans rats. After alkaline injury of the central part of the lower palpebral conjunctiva bilaterally, VApal eye drops at 1,500 IU/mL in one eye and a vehicle in the fellow eye were both administered 6 times a day for 7 days...
January 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28007113/effect-of-postoperative-administration-of-nonsteroidal-antiinflammatory-drugs-and-steroids-on-the-conformational-changes-in-wound-healing-after-cataract-surgery
#8
Eun Young Choi, Hyun Goo Kang, Tae-Im Kim, Eung Kwoen Kim, Hyung Keun Lee
PURPOSE: To assess the changes in clear corneal incision (CCI) healing resulting from the postoperative administration of nonsteroidal antiinflammatory drugs (NSAIDs) or steroids using anterior segment optical coherence tomography (AS-OCT). SETTING: Institute of Vision Research, Department of Ophthalmology, Yonsei University, Seoul, South Korea. DESIGN: Prospective randomized comparative study. METHODS: Eyes having cataract surgery were randomly given an NSAID (bromfenac 0...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28002112/wet-peeling-technique-of-deep-anterior-lamellar-keratoplasty-with-hypotonic-water-and-blunt-dissection-for-healed-hydrops
#9
Zelin Zhao, Jinyang Li, Qinxiang Zheng, Wei Lin, Vishal Jhanji, Wei Chen
PURPOSE: To describe the surgical technique and outcomes of "wet-peeling" deep anterior lamellar keratoplasty (DALK) using sterile water and blunt dissection in cases with corneal scarring after healed corneal hydrops. METHODS: Manual DALK using a "wet-peeling" technique was performed in 20 eyes of 20 consecutive patients with healed corneal hydrops between June 2011 and October 2013. RESULTS: Intraoperative microperforations were encountered in 2 (10%) cases...
December 20, 2016: Cornea
https://www.readbyqxmd.com/read/27998771/deficiency-in-ubiquitin-like-protein-ubl4a-impairs-migration-of-fibroblasts-and-macrophages
#10
Yu Zhao, Huaiyuan Zhang, Carlos Affonso, Raiza Bonomo, Adriana Mañas, Jialing Xiang
Ubiquitin-like protein Ubl4A is a small, multi-functional protein with no ubiquitination activity. We have previously demonstrated that Ubl4A directly interacts with actin-related protein 2/3 complex (Arp2/3) and promotes Arp2/3-dependent actin branching, thereby accelerating plasma membrane translocation of protein kinase Akt upon insulin stimulation. Here, we show that Ubl4A is critical for plasma membrane protrusion and cell migration. Ubl4A, F-actin and Arp2/3 are co-localized at the cell leading edges during wound closure...
December 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27990355/corneal-collagen-cross-linking-and-liposomal-amphotericin-b-combination-therapy-for-fungal-keratitis-in-rabbits
#11
Zhao-Qin Hao, Jin-Xin Song, Shi-Yin Pan, Lin Zhang, Yan Cheng, Xian-Ning Liu, Jie Wu, Xiang-Hua Xiao, Wei Gao, Hai-Feng Zhu
AIM: To observe the therapeutic effect of corneal collagen cross-linking (CXL) in combination with liposomal amphotericin B in fungal corneal ulcers. METHODS: New Zealand rabbits were induced fungal corneal ulcers by scratching and randomly divided into 3 groups, i.e. control, treated with CXL, and combined therapy of CXL with 0.25% liposomal amphotericin B (n=5 each). The corneal lesions were documented with slit-lamp and confocal microscopy on 3, 7, 14, 21 and 28d after treatment...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27989569/comparison-of-the-effects-of-various-lubricant-eye-drops-on-the-in-vitro-rabbit-corneal-healing-and-toxicity
#12
R Michael Dutescu, Claudia Panfil, Norbert Schrage
Ingredients of lubricant eye drops are potentially harmful to the ocular surface. The products Optive, Optive Fusion, Neopt were tested regarding corneal irritability versus Vismed Multi and 0.01% benzalkonium chloride as negative and positive control, respectively. Formulas (30-40μl per hour) were applied hourly in-vitro for six days on rabbit corneas (n=5, per product) cultured in artificial anterior chambers (EVEIT system). Initially, four corneal abrasions (2.4-4.6mm(2)) were induced. All defects were monitored during drop application by fluorescein stains and photographs...
December 15, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27951595/corneal-endothelial-cell-migration-and-proliferation-enhanced-by-rho-kinase-rock-inhibitors-in-in-vitro-and-in-vivo-models
#13
Landon C Meekins, Noel Rosado-Adames, Rupalatha Maddala, Jiagang J Zhao, Ponugoti V Rao, Natalie A Afshari
Purpose: To explore the role of Rho-associated kinases (ROCK) in corneal physiology and regeneration, and the effects of suppressing its activity in stimulating corneal endothelial cell proliferation and migration in vitro and in vivo. Methods: Immunohistochemistry was performed to detect RhoA and ROCK-1 and ROCK-2 in human corneal tissue. Adult porcine corneal endothelial cells (CECs) were isolated, grown to confluence, and further characterized. Under the treatment of ROCK inhibitors, changes in the cellular distribution profile of ZO-1 and F-actin were examined by immunofluorescence staining...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27930794/using-donor-lenticules-obtained-through-smile-for-an-epikeratophakia-technique-combined-with-phototherapeutic-keratectomy
#14
Jing Zhao, Ling Sun, Yang Shen, Mi Tian, Peijun Yao, Xingtao Zhou
PURPOSE: To investigate the feasibility, safety, and efficacy of using a donor lenticule created during small incision lenticule extraction (SMILE) in an epikeratophakia technique combined with phototherapeutic keratectomy (PTK). METHODS: Six patients with decreased visual acuity due to a recurrence of corneal dystrophy were included in this prospective pilot study. PTK was performed using the MEL 80 excimer laser (Carl Zeiss Meditec, Jena, Germany) followed by the transplantation of donor lenticules onto the recipient eyes...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27930505/increased-membrane-localization-of-pannexin1-in-human-corneal-synaptosomes-causes-enhanced-stimulated-atp-release-in-chronic-diabetes-mellitus
#15
Hao Cui, Ying Liu, Limin Qin, Liqiang Wang, Yifei Huang
In the present study, we investigated the potential changes in the corneal nerve terminals in non-insulin-dependent diabetes mellitus of moderate duration. The dissected corneas were subjected to a protocol of ultracentrifugation to obtain synaptosomes of sensory nerve terminals. Within these nerve varicosities, 2 major mechanisms were examined, viz., alterations of the mechanosensitive channel pannexin1 and ATP release on stimulation of these terminals. We hypothesized that altered cellular location and function of the pannexin channel may contribute to altered mechanosensitivity of the cornea, which in turn may affect wound healing and primary visual function of the cornea...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27917718/the-role-of-rho-kinase-inhibitors-in-corneal-endothelial-dysfunction
#16
Naoki Okumura, Shigeru Kinoshita, Noriko Koizumi
BACKGROUND: The cornea is transparent tissue that serves as the window of the eye, allowing light to enter from the outer environment. The corneal endothelium maintains corneal transparency; thus, its dysfunction results in corneal haziness and causes severe vision loss. The only available therapeutic choice for treating corneal endothelial dysfunction has been transplantation using donor corneas; consequently, researchers have been pressed to develop new therapeutic options. METHODS: The goal of the review is to provide an overview of the research into Rho kinase (ROCK) inhibitors in the field of corneal endothelium therapy and the potential for clinical use of ROCK inhibitors...
December 5, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27909310/undiluted-serum-eye-drops-for-the-treatment-of-persistent-corneal-epitheilal-defects
#17
Kaevalin Lekhanont, Passara Jongkhajornpong, Thunyarat Anothaisintawee, Varintorn Chuckpaiwong
Several studies found that 50-100% serum eye drops provided greater benefits without inducing detrimental effects on the corneal epithelial healing. This study assessed the efficacy of undiluted serum eye drops for the treatment of persistent corneal epithelial defects (PED). A total of 109 eyes received 100% serum eye drops for PED were recruited into this study. The data were compared with an historical control group of 79 eyes with PED who received conventional treatments from 2006-2011 at the same institution...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905668/subconjunctival-antimicrobial-poloxamer-gel-for-treatment-of-corneal-ulceration-in-stranded-california-sea-lions-zalophus-californianus
#18
Claire A Simeone, Carmen M H Colitz, Kathleen M Colegrove, Cara L Field, Carlos Rios, Heather L Chandler, Shawn P Johnson
OBJECTIVE: Corneal ulcers are commonly encountered in pinnipeds. Prolonged oral antibiotics and topical ophthalmic solutions may not be practical to administer, and novel treatment techniques are desired. Thermodynamic gels are a potential solution because they hold antimicrobials at the site of injection, slowly releasing drug. This study investigated the clinical efficacy of antibiotic-impregnated poloxamer gel in management of corneal ulceration. ANIMAL STUDIED: Twenty-six California sea lions undergoing rehabilitation at The Marine Mammal Center...
December 1, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27898984/transforming-growth-factor-%C3%AE-signaling-cascade-induced-by-mechanical-stimulation-of-fluid-shear-stress-in-cultured-corneal-epithelial-cells
#19
Tsugiaki Utsunomiya, Akihiro Ishibazawa, Taiji Nagaoka, Kazuomi Hanada, Harumasa Yokota, Nobuhito Ishii, Akitoshi Yoshida
Purpose: Because blinking is regarded as mechanical stimulation of fluid shear stress on the corneal epithelial cells, we investigated the effects of fluid shear stress on cultured human corneal epithelial cells (HCECs). Methods: The HCECs were exposed to shear stress (0, 1.2, 12 dyne/cm2) with the parallel-plate type of flow chamber. Wound healing, cellular proliferation, growth factor expression, TGF-β1 concentration in the culture supernatant, and phosphorylation of SMAD2 were investigated...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27897118/smoking-and-eye-pathologies-a-systemic-review-part-i-anterior-eye-segment-pathologies
#20
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health and is one of the leading causes of preventable mortality worldwide, associated with lung cancer, chronic obstructive lung disease and cardiovascular disease. AIM: The analysis of the influence of tobacco smoking on pathology of the anterior segment of the eye in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, was published during the period 2000-2016...
November 29, 2016: Current Pharmaceutical Design
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