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https://www.readbyqxmd.com/read/28803395/isolated-severe-microblepharon-in-a-neonate-a-rare-case
#1
Rachna Meel, Saranya Devi, Anita Ganger, Manasa S, Neelam Pushker
PURPOSE: To report a rare case of isolated severe microblepharon in a neonate. METHODS: A 27 days old male child was brought by parents with redness, photophobia and discharge for two weeks. Thorough ophthalmological and systemic examination was performed. RESULTS: The diagnosis of isolated severe microblepharon with infectious keratitis was made. After the appropriate management of infectious keratitis and achieving complete resolution, the child was subjected to bilateral lid reconstruction was done in the form of upper lid skin grafting and tarsorrhaphy and the patient is being followed up...
August 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28800463/combination-of-dexamethasone-and-avastin-%C3%A2-by-supramolecular-hydrogel-attenuates-the-inflammatory-corneal-neovascularization-in-rat-alkali-burn-model
#2
Jinhai Huang, Wenwen Wang, Jing Yu, Xinxin Yu, Qianqian Zheng, Fangli Peng, Zhifen He, Wenguang Zhao, Zhaoliang Zhang, Xingyi Li, Qinmei Wang
Corneal neovascularization (CNV) is one of the leading causes of vision loss and a high-risk factor for transplant rejection. The present study proposed a supramolecular hydrogel comprised of MPEG-PCL micelles and α-cyclodextrin (α-CD) for co-delivery of dexamethasone sodium phosphate (Dexp) and Avastin(®) (Ava), and further evaluated its therapeutic efficacy in rat alkali burn model. A physical mixing of Dexp/Ava, MPEG-PCL micelles, and α-CD aqueous solution leads to a spontaneous formation of the supramolecular hydrogel via a "host-guest" recognition between MPEG and α-CD...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28799757/immobilization-of-growth-factors-to-collagen-surfaces-using-visible-light
#3
Gabriella Maria Fernandes Cunha, Hyun Jong Lee, Alisha Kumar, Alexander Kreymerman, Sarah Christine Heilshorn, David Myung
In the treatment of traumatic injuries, burns, and ulcers of the eye, inadequate epithelial tissue healing remains a major challenge. Wound healing is a complex process involving the temporal and spatial interplay between cells and their extracellular milieu. It can be impaired by a variety of causes including infection, poor circulation, loss of critical cells and/or proteins, and a deficiency in normal neural signaling (e.g. neurotrophic ulcers). Ocular anatomy is particularly vulnerable to lasting morbidity from delayed healing, whether it be scarring or perforation of the cornea, destruction of the conjunctival mucous membrane, or cicatricial changes to the eyelids and surrounding skin...
August 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28782549/a-review-of-the-evidence-for-in-vivo-corneal-endothelial-regeneration
#4
REVIEW
Bert Van den Bogerd, Sorcha Ní Dhubhghaill, Carina Koppen, Marie-José Tassignon, Nadia Zakaria
Human corneal endothelium has long been thought to be a non-mitotic cell layer with no endogenous reparative potential. Pathologies that damage endothelial function result in corneal decompensation and, if untreated, blindness. The mainstay of treatment involves partial or complete corneal replacement, amounting to 40% of all corneal transplants performed worldwide. We summarize the case reports describing complications post-operatively in the form of (sub)total graft detachment and those resulting in post-operative bare stroma...
August 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28775086/tailored-lamellar-keratoplasty-a-new-technique
#5
Mohammad Solaimani, Seyed Ali Tabatabaei, Zahra Fallah Tafti
We present a new method for treating complicated corneal gaps among patients who have previously undergone radial keratotomy (RK).After complete healing of a fungal keratitis in a patient who has undergone RK, we removed the oedematous corneal sector and put anterior tailored segment of a corneal button previously used for Descemet stripping endothelial keratoplasty. The patient's best-corrected visual acuity reached to 20/20 6 months later. This technique will compensate for oedematous parts without putting a significant effect on other parts such as purse string sutures...
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28772877/protein-based-drug-delivery-materials
#6
REVIEW
Dave Jao, Ye Xue, Jethro Medina, Xiao Hu
There is a pressing need for long-term, controlled drug release for sustained treatment of chronic or persistent medical conditions and diseases. Guided drug delivery is difficult because therapeutic compounds need to survive numerous transport barriers and binding targets throughout the body. Nanoscale protein-based polymers are increasingly used for drug and vaccine delivery to cross these biological barriers and through blood circulation to their molecular site of action. Protein-based polymers compared to synthetic polymers have the advantages of good biocompatibility, biodegradability, environmental sustainability, cost effectiveness and availability...
May 9, 2017: Materials
https://www.readbyqxmd.com/read/28765880/microrna%C3%A2-494-inhibits-nerve-growth-factor%C3%A2-induced-cell-proliferation-by-targeting-cyclin-d1-in-human-corneal-epithelial-cells
#7
Dan Wu, Tingting Qian, Jiaxu Hong, Gang Li, Weiyun Shi, Jianjiang Xu
Nerve growth factor (NGF) is expressed in the human corneal epithelium and stroma. It is an efficient therapy for human corneal ulcers caused by neurotropic disease. However, little is known about the molecular mechanism of NGF in healing human corneal epithelial diseases. Numerous microRNAs (miRNAs) are expressed in the cornea and miRNAs have important roles in regulating corneal development. In the present study, novel miRNA regulators were demonstrated to be involved in NGF‑induced human corneal epithelial cell (hCEC) proliferation...
July 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28765543/descemet-s-membrane-supports-corneal-endothelial-cell-regeneration-in-rabbits
#8
Jingyao Chen, Zhiyuan Li, Liying Zhang, Shangkun Ou, Yanzi Wang, Xin He, Dulei Zou, Changkai Jia, Qianqian Hu, Shu Yang, Xian Li, Juan Li, Junqi Wang, Huimin Sun, Yongxiong Chen, Ying-Ting Zhu, Scheffer C G Tseng, Zuguo Liu, Wei Li
Descemet's membrane (DM) helps maintain phenotype and function of corneal endothelial cells under physiological conditions, while little is known about the function of DM in corneal endothelial wound healing process. In the current study, we performed in vivo rabbit corneal endothelial cell (CEC) injury via CEC scraping, in which DM remained intact after CECs removal, or via DM stripping, in which DM was removed together with CECs. We found rabbit corneas in the CEC scraping group healed with transparency restoration, while there was posterior fibrosis tissue formation in the corneas after DM stripping on day 14...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751979/application-of-rho-kinase-inhibitors-for-the-treatment-of-corneal-endothelial-diseases
#9
REVIEW
Naoki Okumura, Shigeru Kinoshita, Noriko Koizumi
ROCK (Rho kinase) signaling regulates a wide spectrum of fundamental cellular events and is involved in a variety of pathological conditions. It has therefore attracted research interest as a potential therapeutic target for combating various diseases. We showed that inhibition of ROCK enhances cell proliferation, promotes cell adhesion onto a substrate, and suppresses apoptosis of corneal endothelial cells (CECs). In addition, we reported that a ROCK inhibitor enhances wound healing in the corneal endothelium in animal models and in pilot clinical research...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28748596/concise-review-stem-cells-for-corneal-wound-healing
#10
REVIEW
Mehrnoosh Saghizadeh, Andrei A Kramerov, Clive N Svendsen, Alexander V Ljubimov
Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clearly play a role in this process, whereas the contribution of stromal and endothelial progenitors is less well studied. The available evidence on stem cell participation in corneal wound healing is reviewed, together with the data on the use of corneal and non-corneal stem cells to facilitate this process in diseased or postsurgical conditions...
July 26, 2017: Stem Cells
https://www.readbyqxmd.com/read/28745656/-effect-of-medicinal-treatment-on-epithelial-wound-healing-after-phacoemulsification
#11
E V Tomilova, M N Nemsitsveridze, I E Panova
AIM: to compare the dynamics of epithelial wound healing under two different post-op treatments in patients after uncomplicated phacoemulsification. MATERIAL AND METHODS: This prospective randomized clinical trial included 40 eyes of 40 patients aged 66.4±8.2 years who underwent uncomplicated phacoemulsification with flexible intraocular lens implantation through a 2.2-mm corneal incision. Patients were randomized to receive either dexamethasone 0.1% and diclofenac 0...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28739646/koh-mount-as-an-aid-in-the-management-of-infectious-keratitis-at-secondary-eye-care-centre
#12
Varsha M Rathi, Monica Thakur, Savitri Sharma, Rohit Khanna, Prashant Garg
AIMS: To report the clinical outcome of infectious keratitis managed after doing 10% KOH mount of corneal smears and reporting done by an ophthalmologist in the secondary eye care centre in South India. METHODS: 103 consecutive cases of microbial keratitis were studied. Inclusion criteria were presence of corneal infiltrate on slit lamp biomicroscopy. An ophthalmologist carried out microbiological evaluation of 10% KOH mount of corneal scrapings. No cultures were done at secondary centres...
July 24, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730081/effect-of-human-autologous-serum-and-fetal-bovine-serum-on-human-corneal-epithelial-cell-viability-migration-and-proliferation-in-vitro
#13
Ming-Feng Wu, Tanja Stachon, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry
AIM: To analyze the concentration-dependent effects of autologous serum (AS) and fetal bovine serum (FBS) on human corneal epithelial cell (HCEC) viability, migration and proliferation. METHODS: AS was prepared from 13 patients with non-healing epithelial defects Dulbecco's modified eagle medium/Ham's F12 (DMEM/F12) with 5% FBS, 0.5% dimethyl sulphoxide (DMSO), 10 ng/mL human epidermal growth factor, 1% insulin-transferrin-selenium, then were incubated in serum media: DMEM/F12 supplemented by 5%, 10%, 15% or 30% AS or FBS...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28715585/retinoic-acid-engineered-amniotic-membrane-used-as-graft-or-homogenate-positive-effects-on-corneal-alkali-burns
#14
Romain Joubert, Estelle Daniel, Nicolas Bonnin, Aurélie Comptour, Christelle Gross, Corinne Belville, Frédéric Chiambaretta, Loïc Blanchon, Vincent Sapin
Purpose: Alkali burns are the most common, severe chemical ocular injuries, their functional prognosis depending on corneal wound healing efficiency. The purpose of our study was to compare the benefits of amniotic membrane (AM) grafts and homogenates for wound healing in the presence or absence of previous all-trans retinoic acid (atRA) treatment. Methods: Fifty male CD1 mice with reproducible corneal chemical burn were divided into five groups, as follows: group 1 was treated with saline solution; groups 2 and 3 received untreated AM grafts or grafts treated with atRA, respectively; and groups 4 and 5 received untreated AM homogenates or homogenates treated with atRA, respectively...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28708898/retreatment-strategies-following-small-incision-lenticule-extraction-smile-in-vivo-tissue-responses
#15
Andri K Riau, Yu-Chi Liu, Chris H L Lim, Nyein C Lwin, Ericia P Teo, Gary H Yam, Donald T Tan, Jodhbir S Mehta
With any refractive correction, including Small Incision Lenticule Extraction (SMILE), there may be a residual refractive error that requires a retreatment. Here, we investigated the tissue responses following various retreatment procedures in a rabbit model of SMILE. All rabbits underwent a -6.00D correction with SMILE. Two weeks later, they underwent -1.00D enhancement by: (i) VisuMax Circle, followed by excimer ablation (S+C); (ii) secondary SMILE anterior to the primary procedure (S+SE); or (iii) surface ablation (S+P), and were examined for 28 days...
2017: PloS One
https://www.readbyqxmd.com/read/28704790/pharmacological-activities-of-an-eye-drop-containing-matricaria-chamomilla-and-euphrasia-officinalis-extracts-in-uvb-induced-oxidative-stress-and-inflammation-of-human-corneal-cells
#16
Elisabetta Bigagli, Lorenzo Cinci, Mario D'Ambrosio, Cristina Luceri
Ultraviolet B (UVB) exposure is a risk factor for corneal damage resulting in oxidative stress, inflammation and cell death. The aim of this study was to investigate the potential protective effects of a commercial eye drop (Dacriovis™) containing Matricaria chamomilla and Euphrasia officinalis extracts on human corneal epithelial cells (HCEC-12) against UVB radiation-induced oxidative stress and inflammation as well as the underlying mechanisms. The antioxidant potential of the eye drops was evaluated by measuring the ferric reducing antioxidant power and the total phenolic content by Folin-Ciocalteu reagent...
June 24, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28700779/corneal-wound-repair-after-rose-bengal-and-green-light-crosslinking-clinical-and-histologic-study
#17
Patricia Gallego-Muñoz, Lucía Ibares-Frías, Elvira Lorenzo, Susana Marcos, Pablo Peréz-Merino, Nandor Bekesi, Irene E Kochevar, M Carmen Martínez-García
Purpose: To evaluate corneal wound healing after treatment with a new collagen crosslinking protocol using rose bengal dye and green light (RGX). Methods: One cornea of 20 New Zealand rabbits was de-epithelialized (DE) in an 8-mm diameter circle and, in another group (n = 25), the DE corneas were then stained with 0.1% rose bengal for 2 minutes and exposed to green light (532 nm) for 7 minutes (RGX). The contralateral eyes without treatment acted as controls. The animals were clinically followed including fluorescein staining and pachymetry...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28691943/effect-of-a-new-matrix-therapy-agent-in-persistent-epithelial-defects-after-bacterial-keratitis-treated-with-topical-fortified-antibiotics
#18
Marc-Antoine Chappelet, Diane Bernheim, Christophe Chiquet, Florent Aptel
PURPOSE: To evaluate the effect of topical application of a matrix regenerating agent (RGTA) in subjects with a persistent epithelial defect after bacterial keratitis treated with topical fortified antibiotics. METHODS: In this prospective case series of 14 subjects (14 eyes) with a persisting corneal ulcer after the cessation of fortified antibiotics, subjects were treated with an RGTA at a dose of 1 drop every other day. The main outcome measure was the proportion of subjects with complete corneal healing 1 month after initiation of treatment...
July 6, 2017: Cornea
https://www.readbyqxmd.com/read/28688026/indications-and-graft-survival-analysis-in-optical-penetrating-keratoplasty-in-a-tertiary-care-center-in-north-india-a-5-year-study
#19
Sudesh Kumar Arya, Amit Raj, Ravi Kant Bamotra, Anubha Bhatti, Jyoti Deswal, Meenakshi Sindhu
PURPOSE: To study the indications and variables correlating with graft survival in optical penetrating keratoplasty in a tertiary care hospital in north India. PARTICIPANTS: All patients who underwent optical keratoplasty, except those undergoing lamellar grafts, tectonic grafts transplants and penetrating keratoplasty done for therapeutic purposes were included in the study. Patients with follow-up less than 2 years were excluded from the study. MATERIALS AND METHODS: Data were obtained by reviewing the records of 101 patients who underwent optical penetrating keratoplasty from 2008 to 2013 for various indications...
July 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28676989/in-vivo-and-ex-vivo-evaluation-of-cell-cell-interactions-adhesion-and-migration-in-ocular-surface-of-patients-undergone-excimer-laser-refractive-surgery-after-topical-therapy-with-different-lubricant-eyedrops
#20
Roberta Calienno, Claudia Curcio, Manuela Lanzini, Mario Nubile, Leonardo Mastropasqua
PURPOSE: To investigate, in vivo by means of in vivo confocal microscopy (IVCM) and ex vivo by impression cytology, epithelial cellular damage after excimer laser refractive surgery in patients under different topical lubricant therapies. METHODS: Two hundred eyes of 100 patients, undergone bilateral excimer laser refractive surgery for medium myopic error correction [spherical equivalent refraction from -1.75 to -3.50 dioptres (D) with refractive astigmatism under -0...
July 4, 2017: International Ophthalmology
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