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https://www.readbyqxmd.com/read/29331377/%C3%AE-cellulin-promotes-the-proliferation-of-corneal-epithelial-stem-cells-through-the-phosphorylation-of-erk1-2
#1
Won-Yong Jeong, Hye-Young Yoo, Chan-Wha Kim
The proliferation of corneal epithelial stem cells (CESCs) is a very important process in the recovery of corneal wounds. Recent studies have shown that β-cellulin (BC) is effective in the repair of other tissues. However, its mechanism of action in corneal wound healing is not yet clear. The purpose of this study was to investigate how BC accelerates wound healing of the cornea. Here, we confirmed that the proliferation of CESCs was induced at a specific concentration (0.2, 2 and 20 ng/mL) by treatment with BC...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29326852/unusual-course-of-crystalline-keratopathy-in-a-patient-with-graft-versus-host-disease
#2
Başak Bostancı, Yonca Aydın Akova
We present a case of infectious crystalline keratopathy in a patient with Graft-versus-Host disease (GVHD) who developed satellite fungal keratitis. A 51-year-old man was referred for bilateral total persistent corneal epithelial defects with severe dry eye. Although persistent epithelial defect healed with medical therapy, he developed stromal keratitis with satellite lesions confirmed to be secondary to Candida albicans. After three months of antifungal treatment and debridement, improvement of the infiltrates was obtained...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29320729/corneal-committed-cells-restore-the-stem-cell-pool-and-tissue-boundary-following-injury
#3
Waseem Nasser, Aya Amitai-Lange, Despina Soteriou, Rana Hanna, Beatrice Tiosano, Yaron Fuchs, Ruby Shalom-Feuerstein
During morphogenesis, preserving tissue boundaries is essential for cell fate regulation. While embryonic tissues possess high plasticity and repair ability, the questions of whether and how adult tissues cope with acute stem cell (SC) loss or boundary disruption have remained unanswered. Here, we report that K15-GFP transgene labels the murine corneal epithelial boundary and SC niche known as the limbus. K15-GFP+ basal cells expressed SC markers and were located at the corneal regeneration site, as evident by lineage tracing...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29315443/pathophysiology-of-corneal-scarring-in-persistent-epithelial-defects-after-prk-and-other-corneal-injuries
#4
Steven E Wilson, Carla S Medeiros, Marcony R Santhiago
PURPOSE: To analyze corneal persistent epithelial defects that occurred at 3 to 4 weeks after -4.50 diopter (D) photorefractive keratectomy (PRK) in rabbits and apply this pathophysiology to the treatment of persistent epithelial defects that occur after any corneal manipulations or diseases. METHODS: Two of 168 corneas that had -4.50 D PRK to study epithelial basement membrane regeneration developed spontaneous persistent epithelial defects that did not heal at 3 weeks after PRK...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29315437/evaluation-of-femtosecond-laser-versus-manual-clear-corneal-incisions-in-cataract-surgery-using-spectral-domain-optical-coherence-tomography
#5
Xiaogang Wang, Zhe Zhang, Xiaoyan Li, Lisha Xie, Haining Zhang, Douglas D Koch, Li Wang, Suhua Zhang
PURPOSE: To investigate the wound healing changes of clear corneal incisions performed with a femtosecond laser or a steel bevel knife in cataract surgery using spectral-domain optical coherence tomography. METHODS: Prospectively, consecutive patients undergoing either femtosecond laser-assisted cataract surgery (femtosecond laser group) using the LenSx laser (Alcon Laboratories, Inc., Fort Worth, TX) or traditional cataract surgery using steel blades (control group) were enrolled...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29301512/epithelial-changes-with-corneal-punctate-epitheliopathy-in-type-2-diabetes-mellitus-and-their-correlation-with-time-to-healing
#6
Jing-Hao Qu, Li Li, Lei Tian, Xiao-Yu Zhang, Ravi Thomas, Xu-Guang Sun
BACKGROUND: To study basal epithelial cell (BEC), sub-basal nerve plexus (SBN) and Langerhans cell (LC) density in patients with type 2 diabetes mellitus (T2DM) with corneal punctate epitheliopathy (CPE) and to assess their association with time to healing of CPE. METHODS: Retrospective study of in vivo confocal microscopy (IVCM) in 160 eyes from 160 patients with T2DM diagnosed with CPE due to a single cause. Key exclusion criteria included multiple-causes for CPE or treatment with autologous serum...
January 4, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29296555/irritant-contact-keratitis-caused-by-the-bodily-fluids-of-a-brown-marmorated-stink-bug
#7
Yi-Syun Shen, Chao-Chien Hu
PURPOSE: The brown marmorated stink bug is native to Asia (China, Taiwan, Japan, and the Korean peninsula). Its bodily fluids are toxic and irritating to the human skin and eyes. Human case reports are rare. Only one report of irritant contact dermatitis has been published. We report a case of irritant contact keratitis resulting from the chemical components of the bodily fluids of the bug. MATERIALS AND METHODS: A case report. RESULTS: A 74-year-old male presented to our emergency department with pain and redness in his right eye, which had been exposed to the bodily fluids of a brown marmorated stink bug...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29295590/proposal-of-a-novel-natural-biomaterial-the-scleral-ossicle-for-the-development-of-vascularized-bone-tissue-in-vitro
#8
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone. The current standard treatments include allografting, autografting, and other bone implant techniques. However, although they are commonly used in orthopedic surgery, these treatments have some limitations concerning their costs and their side effects such as potential infections or malunions. On this account, the need for suitable constructs to fill the gap in wide fractures is still urgent...
December 25, 2017: Biomedicines
https://www.readbyqxmd.com/read/29288733/ophthalmic-gels-past-present-and-future
#9
Ali A Al-Kinani, Ghada Zidan, Naba Elsaid, Ali Seyfoddin, Adam W G Alani, Raid G Alany
Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve sustained and therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based, intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes...
December 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29282831/bmi1-progenitor-cell-dynamics-in-murine-cornea-during-homeostasis-and-wound-healing
#10
Solja Kalha, Bideep Shrestha, Maria Sanz Navarro, Kyle B Jones, Ophir D Klein, Frederic Michon
The outermost layer of the eye, the cornea, is renewed continuously throughout life. Stem cells of the corneal epithelium reside in the limbus at the corneal periphery and ensure homeostasis of the central epithelium. However, in young mice, homeostasis relies on cells located in the basal layer of the central corneal epithelium. Here, we first studied corneal growth during the transition from newborn to adult and assessed Keratin 19 (Krt19) expression as a hallmark of corneal maturation. Next, we set out to identify a novel marker of murine corneal epithelial progenitor cells before, during and after maturation, and we found that Bmi1 is expressed in the basal epithelium of the central cornea and limbus...
December 28, 2017: Stem Cells
https://www.readbyqxmd.com/read/29260079/a-stepping-stone-in-treating-dendritic-keratitis
#11
Hosam Sheha, Sean Tighe, Anny M S Cheng, Scheffer C G Tseng
Purpose: To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. Observations: A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained amniotic membrane. Five days after treatment, the patient experienced a complete resolution of symptoms, marked reduction of inflammation, complete re-epithelialization of the cornea and improvement of visual acuity...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259285/peroxisome-proliferator-activated-receptor-alpha-agonist-suppresses-neovascularization-by-reducing-both-vascular-endothelial-growth-factor-and-angiopoietin-2-in-corneal-alkali-burn
#12
Takeshi Arima, Masaaki Uchiyama, Yuichiro Nakano, Shinya Nagasaka, Dedong Kang, Akira Shimizu, Hiroshi Takahashi
We investigated the effect of a peroxisome proliferator-activated receptor alpha (PPARα) agonist ophthalmic solution in wound healing using a rat corneal alkali burn model. After instillation of a selective agonist of PPARα, fenofibrate, onto the burned cornea, PPARα-positive cells were observed in vascular endothelial cells, and there was upregulation of mRNA of PPARα in corneal stroma. Fenofibrate suppressed expression of neutrophils and macrophages during the early phase, and development of neovascularization and myofibroblast generation during the late phase...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29251403/rebamipide-suppresses-tnf-%C3%AE-production-and-macrophage-infiltration-in-the-conjunctiva
#13
Kazuki Tajima, Takaaki Hattori, Hiroki Takahashi, Haruki Katahira, Akitomo Narimatsu, Shigeto Kumakura, Hiroshi Goto
PURPOSE: To evaluate the anti-inflammatory effect of rebamipide during corneal epithelial wound healing using a mouse wound repair model. METHODS: A 2-mm circular disc of the central cornea was demarcated in the right eye of C57BL/6 mice and the epithelium removed. Rebamipide 2% eyedrop was instilled onto the wounded eye 5 times a day (n = 26). Phosphate-buffered saline (PBS) was used in the control group (n = 26). Corneal and conjunctival IL-1β and TNF-α levels were measured at 6 h and 24 h postinjury by ELISA...
December 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29223650/dry-eye-following-cataract-surgery-the-effect-of-light-exposure-using-an-in-vitro-model
#14
Tugce Ipek, Mariana Petronela Hanga, Andreas Hartwig, James Wolffsohn, Clare O'Donnell
PURPOSE: Cataract surgery can lead to the temporary development or worsening of dry eye symptoms. Contributing factors may include corneal incisions, agents used before, during or after surgery, light from the operating microscope, disruption of ocular surface tissues and inflammatory processes. The purpose of this study was to observe the effect of light exposure on conjunctival fibroblasts in order to determine whether light has an effect on wound healing closure, assuming that operating microscopes might have an effect on the ocular surface...
December 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29217021/practice-patterns-in-the-interdisciplinary-management-of-corneal-abrasions
#15
Michael Ross, Jean Deschênes
OBJECTIVE: To characterize the treatment and follow-up patterns of corneal abrasions at an academic health centre. METHODS: This is a retrospective review of 90 cases of corneal abrasions over a 2-year period at a tertiary care academic hospital, of which 75 were seen by the ophthalmology department. All consultations primarily for corneal abrasion, as determined by the emergency department physician, were included in the study. Information on treatment regimen, corneal findings by emergency and ophthalmology physicians, time between follow-ups, and final outcomes was collected...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29209447/nrf2-a-potential-therapeutic-target-against-oxidative-stress-in-corneal-diseases
#16
REVIEW
Xiu-Fen Liu, Dan-Dan Zhou, Tian Xie, Tayyab Hamid Malik, Cheng-Bo Lu, Hai-Jun Li, Fan Wang, Chang Shu, Cong Liu, Cheng-Wei Lu, Ji-Long Hao
Corneal diseases are one of the major causes of blindness worldwide. Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired. Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology- (ECH-) associated protein 1 (Keap1)/antioxidant response element (ARE) signaling is well known as one of the main antioxidative defense systems...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29206194/adipose-derived-stem-cells-for-corneal-wound-healing-after-laser-induced-corneal-lesions-in-mice
#17
Marco Zeppieri, Maria Letizia Salvetat, Antonio Beltrami, Daniela Cesselli, Rossella Russo, Ignacio Alcalde, Jesús Merayo-Lloves, Paolo Brusini, Pier Camillo Parodi
The aim of our study was to assess the clinical effectiveness of topical adipose derived stem cell (ADSC) treatment in laser induced corneal wounds in mice by comparing epithelial repair, inflammation, and histological analysis between treatment arms. Corneal lesions were performed on both eyes of 40 mice by laser induced photorefractive keratectomy. All eyes were treated with topical azythromycin bid for three days. Mice were divided in three treatment groups (n = 20), which included: control, stem cells and basic serum; which received topical treatment three times daily for five consecutive days...
December 5, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29205032/apratyramide-a-marine-derived-peptidic-stimulator-of-vegf-a-and-other-growth-factors-with-potential-application-in-wound-healing
#18
Weijing Cai, Lilibeth A Salvador-Reyes, Wei Zhang, Qi-Yin Chen, Susan Matthew, Ranjala Ratnayake, Soo Jung Seo, Simon Dolles, Daniel J Gibson, Valerie J Paul, Hendrik Luesch
A novel linear depsipeptide enriched with tyrosine-derived moieties, termed apratyramide, was isolated from an apratoxin-producing cyanobacterium. The structure was determined using a combination of NMR spectroscopy, mass spectrometry, and chiral analysis of the acid hydrolyzate and confirmed by total synthesis. Apratyramide up-regulated multiple growth factors at the transcript level in human keratinocyte (HaCaT) cells and induced the secretion of vascular endothelial growth factor A (VEGF-A) from HaCaT cells, suggesting the compound's potential wound-healing properties through growth factor induction...
December 5, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29203068/prospective-randomized-trial-of-corneal-cross-linking-riboflavin-dosing-frequencies-for-treatment-of-keratoconus-and-corneal-ectasia
#19
Marianne O Price, Kelly Fairchild, Matthew T Feng, Francis W Price
PURPOSE: To investigate whether the riboflavin dosing frequency affects corneal cross-linking efficacy or safety, given that isotonic riboflavin solution is viscous and each installation coats the corneal surface with a film that absorbs some of the incident ultraviolet A light. DESIGN: Prospective, randomized, single-center equivalence trial. PARTICIPANTS: Patients with progressive keratoconus or ectasia after refractive surgery (n = 510)...
December 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29201190/pigment-epithelium-derived-factor-short-peptides-facilitate-full-thickness-cutaneous-wound-healing-by-promoting-epithelial-basal-cell-and-hair-follicle-stem-cell-proliferation
#20
Shawn H Tsai, Li-Pen Tsao, Shih-Hsin Chang, Tsung-Chuan Ho, Kwang-Yi Tung, Ai-Ching Wu, Yeou-Ping Tsao
A previous study by our group showed that a 44-amino-acid fragment of pigment epithelium-derived factor (PEDF) facilitated corneal epithelial wound healing. In the present study this fragment was shortened to obtain peptides of 18, 20 and 29 amino acids in length, and their promoting effects on the healing of full-thickness skin wounds were assessed. Peptides were delivered periodically by topical application to punch wounds of mice. The wound healing speed was evaluated by measuring the reduction of wound areas at 4 and 7 days after injury...
November 2017: Experimental and Therapeutic Medicine
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