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https://www.readbyqxmd.com/read/29767448/development-and-validation-of-a-fast-and-sensitive-uhplc-esi-ms-method-for-the-simultaneous-quantification-of-spironolactone-and-its-metabolites-in-ocular-tissues
#1
Naoual Dahmana, Doris Gabriel, Robert Gurny, Yogeshvar N Kalia
Glucocorticoids are a mainstay for the treatment of immune-mediated conditions and inflammatory diseases. However, their chronic use causes numerous side-effects including delays in corneal and cutaneous wound healing. This is attributed to off-target agonism of the mineralocorticoid receptor, which can be reduced by co-administration of a mineralocorticoid receptor antagonist such as spironolactone. The aim of this study was to develop a fast, selective and sensitive UHPLC-ESI-MS method for the simultaneous quantification of spironolactone, its active metabolites - 7α-thiomethylspironolactone and canrenone, the latter's water-soluble prodrug potassium canrenoate, and the synthetic glucocorticoid, dexamethasone, in corneal samples (17α-methyltestosterone served as an internal standard)...
May 16, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29755905/a-case-of-neurotrophic-keratopathy-concomitant-to-brain-metastasis
#2
Chiara Bonzano, Elisabetta Bonzano, Carlo Alberto Cutolo, Riccardo Scotto, Carlo Enrico Traverso
We report a case of a 63-year-old Caucasian female referred to the cornea service of Clinica Oculistica with a neurotrophic corneal ulcer, decreased corneal sensitivity, absent corneal reflex, and decreased lacrimation. The medical record review was relevant for mastectomy and adjuvant therapy for breast cancer complicated by pontocerebellar angle metastasis. Eye patching and application of antibiotic and vitamin ointments were prescribed at first, without a significant improvement. Thus, treatment with autologous serum was started...
March 12, 2018: Curēus
https://www.readbyqxmd.com/read/29753555/evaluation-of-early-postoperative-ocular-pain-after-photorefractive-keratectomy-and-corneal-crosslinking
#3
Siamak Zarei-Ghanavati, Soheyla Jafarpour, Alireza Radyn-Majd, Hamed Hosseinikhah-Manshadi
PURPOSE: To evaluate and compare early postoperative pain after photorefractive keratectomy (PRK) and corneal crosslinking (CXL). SETTING: Khatam-al-Anbia Eye Hospital, Mashhad, Iran. DESIGN: Prospective case series. METHODS: The PRK group included patients with simple refractive errors whereas the CXL group included patients with clinical keratoconus. The groups were compared regarding the level of pain based on the visual analogue scale (VAS), verbal rating scale (VRS), and Wong-Baker FACES pain rating scale immediately after surgery, 6 hours postoperatively, and 1, 3, and 7 days postoperatively...
May 9, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29750729/posterior-lamellar-reconstruction-of-the-lower-eyelid-with-a-gingivoalveolar-mucosal-graft
#4
Yahya Baltu
The anterior and posterior lamellae should be simultaneously reconstructed to repair the upper and lower eyelid's full thickness defects after resection of a malignant tumor. The author described a gingivoalveolar mucosal graft for posterior lamellar reconstruction of the lower eyelid. Between November 2014 and September 2017, 11 patients (6 women, 5 men; mean age 62.7 years) with 13 posterior lamellar defect of lower eyelid underwent reconstruction with gingivoalveolar mucosal graft. The defects ranged from 10 x 8 mm to 20 x 10 mm...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29747422/role-of-bone-morphogenetic-protein-7-bmp7-in-the-modulation-of-corneal-stromal-and-epithelial-cell-functions
#5
Bhavani S Kowtharapu, Ruby Kala Prakasam, Radovan Murín, Dirk Koczan, Thomas Stahnke, Andreas Wree, Anselm G M Jünemann, Oliver Stachs
In the cornea, healing of the wounded avascular surface is an intricate process comprising the involvement of epithelial, stromal and neuronal cell interactions. These interactions result to the release of various growth factors that play prominent roles during corneal wound healing response. Bone morphogenetic proteins (BMPs) are unique multi-functional potent growth factors of the transforming growth factor-beta (TGF-β) superfamily. Treatment of corneal epithelial cells with substance P and nerve growth factor resulted to an increase in the expression of BMP7 mRNA...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29736691/comparison-of-pain-after-subepithelial-versus-conventional-accelerated-corneal-collagen-cross-linking-for-keratoconus
#6
Shaowei Li, Huatao Xie, Man Xu, Meiyan Li, Chang Liu, Jingliang He, Tian Han, Xingtao Zhou
PURPOSE: To compare the postoperative pain and epithelial healing time in conventional and subepithelial accelerated corneal collagen cross-linking (CXL) for progressive keratoconus. METHODS: The medical records of 27 consecutive patients who underwent accelerated CXL for progressive keratoconus were retrospectively reviewed. Patients were divided into two groups: the conventional (n = 16) and the subepithelial accelerated CXL group (n = 11). Corneal epithelial layers with a diameter of 8...
May 7, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29708929/surgical-management-of-herpetic-keratitis
#7
Sonal Tuli, Matthew Gray, Ankit Shah
PURPOSE OF REVIEW: The purpose of this review is to discuss the options for, and recent developments in, the surgical treatment of herpes keratitis. Although the mainstay of treatment of herpetic keratitis is topical or oral antiviral agents, surgical intervention may be necessary for corneal melting or long-term complications such as scarring, lipid keratopathy, necrotizing keratitis, and neurotrophic keratitis. RECENT FINDINGS: There are a number of surgical therapies available for herpes keratitis...
April 27, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29704130/recurrent-corneal-erosion-caused-by-retained-sutures-in-blepharoplasty
#8
I-Hsin Ma, Bo-I Kuo, Yu-Chih Hou
PURPOSE: To present recurrent corneal erosion (RCE) caused by late suture exposure after blepharoplasty. METHODS: Four patients who have unilateral RCE were found to have previous blepharoplasty. The RCE was associated with late suture exposure. The clinical courses, characteristics, methods to identify the suture exposure and treatment were presented. RESULTS: The clinical presentations including local erosion of upper bulbar conjunctiva, corneal abrasion lines, local corneal epithelial defects with rough border, and subepithelial opacity were noticed in all four patients...
April 27, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29702971/plasma-rich-in-growth-factors-membrane-as-coadjuvant-treatment-in-the-surgery-of-ocular-surface-disorders
#9
Ronald M Sanchez-Avila, Jesús Merayo-Lloves, Ana C Riestra, Silvia Berisa, Carlos Lisa, José Alfonso Sánchez, Francisco Muruzabal, Gorka Orive, Eduardo Anitua
To evaluate the safety and efficacy of the surgical use of plasma rich in growth factors fibrin membrane (mPRGF) in different ocular surface pathologies.Fifteen patients with different corneal and conjunctival diseases were included in the study. Patients were grouped according to the use of mPRGF as graft (corneal and/or conjunctival) or dressing; they were also grouped according to the surgical subgroup of intervention (persistent corneal ulcer [PCU], keratoplasty, superficial keratectomy, corneal perforation, and pterygium)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698813/neuropathic-keratopathy
#10
REVIEW
Harminder S Dua, Dalia G Said, Elisabeth M Messmer, Maurizio Rolando, Jose M Benitez-Del-Castillo, Parwez N Hossain, Alex J Shortt, Gerd Gerling, Mario Nubile, Francisco C Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe Baudouin
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor and trophic functions, which can be affected independently or simultaneously. Loss of trophic function and consequent epithelial breakdown exposes the stroma making it susceptible to enzymatic degradation. Nerve pathology can range from attrition to aberrant re-generation with corresponding symptoms from anaesthesia to hyperaesthesia/allodynia...
April 23, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29691018/carboxymethyl-chitosan-gelatin-hyaluronic-acid-blended-membranes-as-epithelia-transplanting-scaffold-for-corneal-wound-healing
#11
Wenhua Xu, Zheying Wang, Ying Liu, Liping Wang, Zhiwen Jiang, Tong Li, Wenhua Zhang, Ye Liang
There is an unmet need for an optimal scaffold as cell transplantation carrier to induce corneal reconstruction. In this study, a blend membrane was prepared with carboxymethyl chitosan (CMCTS), gelatin, and hyaluronic acid. To investigate its cytocompatibility, primary rabbit corneal epithelial cells (CEpCs) were seeded on it and growth and proliferation were evaluated. The blend membrane was found to be transparent, biodegradable, and suitable for CEpCs attachment and proliferation, which could maintain the epithelial cell-like protein expression of CEpCs...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29686390/tissue-remodeling-after-ocular-surface-reconstruction-with-denuded-amniotic-membrane
#12
Jing Jie, Jie Yang, Hui He, Jianlan Zheng, Wenyan Wang, Liying Zhang, Zhiyuan Li, Jingyao Chen, M Vimalin Jeyalatha, Nuo Dong, Huping Wu, Zuguo Liu, Wei Li
Amniotic membrane (AM) has been widely used as a temporary or permanent graft in the treatment of various ocular surface diseases. In this study, we compared the epithelial wound healing and tissue remodeling after ocular surface reconstruction with intact amniotic membrane (iAM) or denuded amniotic membrane (dAM). Partial limbal and bulbar conjunctival removal was performed on New Zealand rabbits followed by transplantation of cryo-preserved human iAM or dAM. In vivo observation showed that the epithelial ingrowth was faster on dAM compared to iAM after AM transplantation...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29681179/-femtosecond-laser-assisted-keratoplasty
#13
László Módis, Eszter Szalai, Zsuzsanna Flaskó, Bence Kolozsvári, András Berta
INTRODUCTION AND AIM: To present our results on femtosecond laser-assisted penetrating keratoplasty. PATIENTS AND METHOD: Twenty-five eyes of 25 patients underwent surgery with the following indications: pseudophakic bullous keratopathy (n = 10), keratoconus (n = 4), corneal dystrophy (n = 5), corneal scar (n = 4), band keratopathy (n = 2). Trephination of both the donor and recipient corneas were performed with VisuMax femtosecond laser device (Carl Zeiss Meditec AG, Jena, Germany)...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29670766/corneal-debridement-combined-with-intrastromal-voriconazole-for-recalcitrant-fungal-keratitis
#14
Yajie Sun, Zhuo Sun, Yukai Chen, Guohua Deng
Background: To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis. Methods: This is a retrospective study. Fourteen patients with recalcitrant fungal keratitis were treated by corneal debridement combined with intrastromal voriconazole (50  μ g/0.1 ml). This paper reviews and analyzes the patients' basic state, surgical intervention, medicinal treatment, and outcomes. Results: The mean sizes of infiltration and ulcer were (5...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29670328/treatment-outcomes-in-the-dry-eye-amniotic-membrane-dream-study
#15
Marguerite B McDonald, Hosam Sheha, Sean Tighe, Susan B Janik, Frank W Bowden, Amit R Chokshi, Michael A Singer, Seema Nanda, Mujtaba A Qazi, Damon Dierker, Adam T Shupe, Brittany J McMurren
Purpose: To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population. Methods: A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29666915/corneal-crosslinking-cxl-with-18-mw-cm-2-irradiance-and-5-4-j-cm-2-radiant-exposure-early-postoperative-safety
#16
Isaak Fischinger, Theo G Seiler, Karthiga Santhirasegaram, Moritz Pettenkofer, Chris P Lohmann, Daniel Zapp
PURPOSE: To investigate safety of accelerated corneal crosslinking during the first postoperative month. METHODS: In this retrospective study, 76 eyes of 60 patients with verified progressive keratectasia were enrolled in this study and followed for 1 month after accelerated CXL (18 mW/cm2 for 5 min, radiant exposure 5.4 J/cm2 ) (A-CXL(5*18)). Preoperatively, objective refraction, slit lamp inspection, and corneal tomography were performed. Early postoperative slit lamp examinations were performed on days 1 and 4...
April 17, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29662125/netrin-1-promotes-diabetic-corneal-wound-healing-through-molecular-mechanisms-mediated-via-the-adenosine-2b-receptor
#17
Yangyang Zhang, Peng Chen, Guohu Di, Xia Qi, Qingjun Zhou, Hua Gao
Netrins are secreted chemoattractants with the roles in axon guidance, cell migration and epithelial plasticity. In the present study, we investigated the roles of netrin-1 in the regulation of corneal epithelial wound healing, inflammation response and nerve fiber regeneration in diabetic mice and cultured corneal epithelial cells. In diabetic mice, the expression of netrin-1 was decreased when compared with that of normal mice. Furthermore, high glucose blocked the wounding-induced up-regulation of netrin-1 expression in corneal epithelial cells...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660329/aquaporin-5-promotes-corneal-wound-healing
#18
S Sindhu Kumari, Murali Varadaraj, Anil G Menon, Kulandaiappan Varadaraj
Aquaporins (AQPs), ordinarily regarded as water channels, have recently been shown to participate in other cellular functions such as cell-to-cell adhesion, cell migration, cell proliferation etc. The current investigation was undertaken to find out whether AQP5 water channel plays a role in corneal epithelial wound healing. Expression of AQP5 in mouse cornea and transfected Madin Darby canine kidney (MDCK) cells was detected using immunofluorescence or EGFP tag. Cell migration and proliferation, the two major events in wound healing, were studied in vitro using cell culture scratch-wound healing model and cell proliferation assay, in vivo by conducting wound healing experiments on corneas of wild-type and AQP5 knockout mouse model and ex vivo on corneal epithelial cells isolated from wild type and AQP5 knockout mice...
April 13, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29656541/a-novel-herpesvirus-associated-with-chronic-superficial-keratitis-and-proliferative-conjunctivitis-in-a-great-horned-owl-bubo-virginianus
#19
Molly D Gleeson, Bret A Moore, Sydney G Edwards, Sarah Stevens, April L Childress, James F X Wellehan, Jessica Robertson, Christopher J Murphy, Michelle G Hawkins, Joanne Paul-Murphy
An adult great-horned owl (Bubo virginianus; GHOW) presented with a history of recurrent corneal ulceration of the right eye (OD). Findings included ulcerative superficial keratitis, proliferative conjunctivitis, and iris pigmentary changes. The ulcer was initially nonresponsive to medical therapy, but showed rapid and appropriate healing following diamond burr debridement. Proliferative conjunctivitis markedly improved following topical antiviral therapy with cidofovir 1%, interferon alpha 2B ophthalmic solutions, and oral l-lysine...
April 14, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29656072/enhanced-wound-healing-of-tissue-engineered-human-corneas-through-altered-phosphorylation-of-the-creb-and-akt-signal-transduction-pathways
#20
Camille Couture, Pascale Desjardins, Karine Zaniolo, Lucie Germain, Sylvain L Guérin
The cornea is a transparent organ, highly specialized and unique that is continually subjected to abrasive forces and occasional mechanical or chemical trauma because of its anatomical localization. Upon injury, the extracellular matrix (ECM) rapidly changes to promote wound healing through integrin-dependent activation of specific signal transduction mediators whose contribution is to favor faster closure of the wound by altering the adhesive and migratory properties of the cells surrounding the damaged area...
April 12, 2018: Acta Biomaterialia
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