keyword
MENU ▼
Read by QxMD icon Read
search

corneal healing

keyword
https://www.readbyqxmd.com/read/28936050/comparative-evaluation-of-corneal-endothelium-in-patients-with-diabetes-undergoing-phacoemulsification
#1
Pramod K Sahu, Gopal K Das, Sumeet Agrawal, Sabitabh Kumar
PURPOSE: The purpose of this study is to determine if phacoemulsification with posterior chamber foldable intraocular lens implantation has a greater impact on the corneal endothelium of type 2 diabetic patients as compared to nondiabetic controls. MATERIALS AND METHODS: This study compared the corneal endothelial status in sixty patients with diabetes with good glycemic control and sixty nondiabetic controls before and after (1 week, 1 month, 2 month, and 3 month) uneventful phacoemulsification...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28935121/treatment-of-acute-ocular-chemical-burns
#2
REVIEW
Namrata Sharma, Manpreet Kaur, Tushar Agarwal, Virender S Sangwan, Rasik B Vajpayee
Ocular chemical burns are an ophthalmic emergency and are responsible for 11.5% to 22.1% of ocular injuries. Immediate copious irrigation is universally recommended in acute ocular burns to remove the offending agent and minimize damage. Conventional medical therapy consists of the use of agents that promote epithelialization, minimize inflammation, and prevent cicatricial complications. Biological fluids such as autologous serum, umbilical cord blood serum, platelet-rich plasma, and amniotic membrane suspension are a rich source of growth factors and promote healing when used as adjuncts to conventional therapy...
September 18, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28931300/-benefits-and-negatives-of-corticosteroid-therapy-in-corneal-pathologies
#3
M Zemanová, V Matušková
INTRODUCTION: Corticosteroid therapy is very beneficial in many types of eye diseases. Corticosteroids are used in the treatment of inflammatory and immunological diseases of the eye. PURPOSE: The aim is to present basic informations about effects of steroids in tissues, their side effects and treatment strategy. METHODS AND RESULTS: Authors process overview of local and systemic steroids and their dosage forms. They refer to the most common problems associated with corticosteroid therapy...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28926886/-keratectomy-combined-with-intrastromal-injection-of-voriconazole-in-treating-fungal-keratitis
#4
S X Li, J Biang, X Li, L T Zhang, W Y Shi
Objective: To investigate the treatment effect of keratectomy combined with intrastromal injection of voriconazole on fungal keratitis. Methods: Retrospective study. Ninety-eight fungal keratitis patients (98 eyes) were treated by keratectomy combined with intrastromal injection of voriconazole in Shandong Eye Hospital from January 2013 to May 2015. The corneal ulcers were mostly located in the paracentral or peripheral cornea, which incompletely blocked the pupil area. Slit lamp and anterior segment optical coherence tomography (AS-OCT) were used for lesion detection...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28917411/accelerated-15%C3%A2-mw-pulsed-light-crosslinking-to-treat-progressive-keratoconus-two-year-clinical-results
#5
Cosimo Mazzotta, Stefano Baiocchi, Simone Alex Bagaglia, Mario Fruschelli, Alessandro Meduri, Miguel Rechichi
PURPOSE: To assess the clinical and microstructural results of accelerated 15 mW pulsed-light corneal crosslinking (CXL) to treat progressive keratoconus. SETTING: Siena Crosslinking Center, Siena, Italy. DESIGN: Prospective case series. METHODS: After epithelium removal (with Epi-Clear) and 10 minutes stromal soaking with riboflavin 0.1% hydroxypropyl methylcellulose solution, all eyes had 15 mW/cm(2) pulsed-light epithelium-off accelerated CXL for 6 minutes of ultraviolet-A (UVA) irradiation (1 second on/1 second off), maintaining a total UVA exposure of 12 minutes at a fluence of 5...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28910175/neurotrophic-keratopathy-therapeutic-approach-using-a-novel-matrix-regenerating-agent
#6
Marta Guerra, Sara Marques, João Quadrado Gil, Joana Campos, Paula Ramos, Andreia Martins Rosa, Maria João Quadrado, Joaquim Neto Murta
PURPOSE: To evaluate the efficacy and tolerance of a new matrix-regenerating agent (RGTA), Cacicol(®), a polymer that mimics heparan sulfates bound to extracellular matrix proteins, avoiding its proteolysis, to treat neurotrophic keratopathy (NK). METHODS: Uncontrolled prospective clinical study performed between January 2014 and May 2016. Twenty-five patients (25 eyes) with corneal neurotrophic ulcers, nonresponsive to at least 2 weeks of conservative therapy, were treated with Cacicol, instilled once/twice a week...
September 14, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28902018/mechanism-of-proliferation-of-cultured-human-corneal-endothelial-cells
#7
Takeshi Joko, Atsushi Shiraishi, Takeshi Kobayashi, Yuichi Ohashi, Shigeki Higashiyama
Because human corneal endothelial cells (HCECs) do not proliferate once the endothelial monolayer has formed, corneal wound healing is believed to be mediated by cell enlargement or migration, rather than by proliferation. However, the cellular mechanisms involved in wound healing by HCECs have not been fully determined. In this review, we focus on the effects of promyelocytic leukemia zinc finger (PLZF), a DNA-binding transcription factor, and transforming growth factor (TGF)-β2 on the proliferation and migration of cultured HCECs...
September 7, 2017: Cornea
https://www.readbyqxmd.com/read/28898355/topical-cross-linked-ha-based-hydrogel-accelerates-closure-of-corneal-epithelial-defects-and-repair-of-stromal-ulceration-in-companion-animals
#8
David L Williams, Barbara M Wirostko, Glenwood Gum, Brenda K Mann
Purpose: The purpose of this study was to determine the safety of topical ocular administration of a cross-linked, modified hyaluronic acid (xCMHA-S) hydrogel, and its effectiveness in accelerating repair and closure of acute and nonhealing corneal ulcers in companion animals as a veterinary treatment and its utility as a model for therapy in human corneal ulceration. Methods: Two concentrations of xCMHA-S (0.33% and 0.75%) were topically administered to the eyes of rabbits six times daily for 28 days to assess safety...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28879155/cylindrocarpon-lichenicola-keratomycosis-in-nigeria-the-challenge-of-limited-access-to-effective-antimicrobials
#9
Emmanuel O Irek, Temitope O Obadare, Patrick A Udonwa, Olajumoke Laoye, Oyekola V Abiri, Adenike O Adeoye, Aaron O Aboderin
INTRODUCTION: We report a rare cause of keratitis, due to Cylindrocarpon lichenicola, in a farmer with keratomycosis. Despite the acknowledged virulence of this fungus, a suitable antifungal for its management was not accessible. CASE PRESENTATION: A 67-year-old farmer presented with a two-week history of pain, mucopurulent discharge, redness and a corneal ulcer with a visual acuity of hand movement in the right eye. With a working diagnosis of infective keratitis, corneal scrapings were taken under a slit lamp biomicroscope for microbiological testing...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28875742/medicated-ocular-bandages-and-corneal-health-potential-excipients-and-active-pharmaceutical-ingredients
#10
Ghada Zidan, Ilva D Rupenthal, Carol Greene, Ali Seyfoddin
Corneal blindness can occur due to improper healing of the corneal tissues after induced injury or abrasion which can be accidental, pathogenic or after corneal surgery. Abnormal regulation of the healing mechanisms can lead to corneal opacity. Reducing inflammation and promoting epithelial wound healing is crucial for scar-free corneal recovery without eyesight complications. Current approaches for corneal wound healing involve amniotic membrane (AM) bandages, bandage contact lenses (BCL) and collagen shields in conjunction with frequent administration of therapeutic eye drops...
September 6, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28875003/inhibition-of-angiogenesis-a-novel-effect-of-zataria-multiflora
#11
Amir Hossein Norooznezhad, Maryam Keshavarz, Fatemeh Norooznezhad, Kamran Mansouri
Background: Angiogenesis, the formation of new blood vessels from preexisting ones, is among the most important physiological and pathological processes that occur in the body. Under pathological conditions such as tumor growth, psoriasis, corneal neovascularization and rheumatoid arthritis, angiogenesis is substantial for the development of the disease. Zataria multiflora is a member of the Labiatae family with a vast range of traditional uses which has been long known and applied in Iran old medicine. The aim of this study was the evaluation of anti-angiogenic potential of Zataria multiflora...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28873283/in-vivo-like-culture-conditions-in-a-bioreactor-facilitate-improved-tissue-quality-in-corneal-storage
#12
Richard Schmid, Ioana-Sandra Tarau, Angela Rossi, Stefan Leonhardt, Thomas Schwarz, Sebastian Schuerlein, Christian Lotz, Jan Hansmann
The cornea is the most-transplanted tissue worldwide. However, the availability and quality of grafts are limited due to the current methods of corneal storage. In this study, a dynamic bioreactor system is employed to enable the control of intraocular pressure and the culture at the air-liquid interface. Thereby, in vivo-like storage conditions are achieved. Different media combinations for endothelium and epithelium are tested in standard and dynamic conditions to enhance the viability of the tissue. In contrast to culture conditions used in eye banks, the combination of the bioreactor and biochrom medium 1 allows to preserve the corneal endothelium and the epithelium...
September 5, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28863216/hyaluronan-rich-microenvironment-in-the-limbal-stem-cell-niche-regulates-limbal-stem-cell-differentiation
#13
Tarsis F Gesteira, Mingxia Sun, Yvette M Coulson-Thomas, Yu Yamaguchi, Lung-Kun Yeh, Vincent Hascall, Vivien J Coulson-Thomas
Purpose: Limbal epithelial stem cells (LSCs), located in the basal layer of the corneal epithelium in the corneal limbus, are vital for maintaining the corneal epithelium. LSCs have a high capacity of self-renewal with increased potential for error-free proliferation and poor differentiation. To date, limited research has focused on unveiling the composition of the limbal stem cell niche, and, more important, on the role the specific stem cell niche may have in LSC differentiation and function...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28861341/blockade-of-angiopoietin-2-tie2-signaling-pathway-specifically-promotes-inflammation-induced-angiogenesis-in-mouse-cornea
#14
Zhi-Xin Yan, Yi Luo, Ning-Fei Liu
AIM: To investigate angiopoietin-2 (Ang-2)/Tie2 signaling pathway involving in inflammatory angiogenesis. METHODS: Three interrupted 11-0 nylon sutures were placed into the corneal stroma of BALB/c mice (6wk old) to induce inflammatory neovascularization. Expression of Ang-2 and Tie2 protein on neovascularization were examined by immunofluorescence. The dynamic expression of Ang-2 mRNA on neovascularization was examined by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28851806/the-deubiquitinase-usp10-regulates-integrin-beta1-and-beta5-and-fibrotic-wound-healing
#15
Stephanie R Gillespie, Liana J Tedesco, Lingyan Wang, Audrey M Bernstein
Scarring and fibrotic disease result from the persistence of myofibroblasts characterized by high surface expression of αv integrins and subsequent activation of TGFβ, however the mechanism controlling their surface abundance is unknown. Genetic screening revealed that human primary stromal corneal myofibroblasts overexpress a subset of deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, preventing degradation. Silencing of the DUB USP10 induces a buildup of ubiquitin on integrins β1 and β5 in cell lysates whereas recombinant USP10 removes ubiquitin from these integrin subunits...
August 29, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28844046/paracrine-effects-of-mesenchymal-stem-cells-on-the-activation-of-keratocytes
#16
Zhixin Jiang, Guangjie Liu, Fanlan Meng, Weiyi Wang, Peng Hao, Yang Xiang, Yuchuan Wang, RuiFang Han, Fang Li, Liming Wang, Xuan Li
AIMS: The purpose of this study is to investigate the impact of mesenchymal stem cell (MSC)-derived soluble factors on the function of keratocytes, with a particular focus on the processes involved in wound healing, including keratocyte activation, migration and proliferation as well as extracellular matrix (ECM) synthesis. METHODS: Primary cultured rabbit keratocytes were treated with MSC-conditioned medium (MSC-CM). The paracrine factors released by bone marrow MSCs were examined by ELISA...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28834817/promotion-of-corneal-epithelial-wound-healing-in-diabetic-rats-by-the-fibronectin-derived-peptide-phsrn
#17
Naoyuki Morishige, Aiko Uemura, Yukiko Morita, Teruo Nishida
PURPOSE: Topical application of the fibronectin-derived peptide PHSRN facilitates corneal epithelial wound healing in healthy animals and in patients with nonhealing epithelial defects. We have now examined the effect of PHSRN eye drops on the healing of corneal epithelial wounds in diabetic rats. METHODS: Wistar rats were injected intraperitoneally with streptozotocin to induce diabetes or with a vehicle as a control. Four weeks after confirmation of the corresponding presence or absence of glycosuria, a 3-mm-diameter portion of the corneal epithelium of the right eye was excised and eye drops containing PHSRN (200 μM) or phosphate-buffered saline (PBS) vehicle were administered to the injured eye every 6 hours...
August 22, 2017: Cornea
https://www.readbyqxmd.com/read/28828764/randomized-controlled-trial-of-topical-insulin-for-healing-corneal-epithelial-defects-induced-during-vitreoretinal-surgery-in-diabetics
#18
Seng Fai, Amin Ahem, Mushawiathi Mustapha, Umi Kalthum Mohd Noh, Mae-Lynn Catherine Bastion
PURPOSE: To determine the effect of topical insulin of 3 concentrations [0.5, 1, and 2 units per drop 4 times per day (QID)] on postoperative corneal epithelial wound healing in diabetic patients. DESIGN: A double blind randomized controlled hospital-based study involving diabetic patients with postoperative corneal epithelial defect after vitreoretinal surgery. METHODS: Diabetic patients were randomized to 3 different concentrations of topical insulin (DTI 0...
August 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28827386/role-of-substance-p-neuropeptide-in-inflammation-wound-healing-and-tissue-homeostasis
#19
REVIEW
Susmit Suvas
Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous system. SP released from the peripheral nerves exerts its biological and immunological activity via high-affinity neurokinin 1 receptor (NK1R). SP is also produced by immune cells and acts as an autocrine or paracrine fashion to regulate the function of immune cells. In addition to its proinflammatory role, SP and its metabolites in combination with insulin-like growth factor-1 are shown to promote the corneal epithelial wound healing...
September 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28827194/midterm-outcomes-of-penetrating-keratoplasty-after-cultivated-oral-mucosal-epithelial-transplantation-in-chemical-burn
#20
Alireza Baradaran-Rafii, Siamak Delfazayebaher, Nasser Aghdami, Ehsan Taghiabadi, Shahram Bamdad, Danial Roshandel
PURPOSE: To evaluate the mid-term outcome of penetrating keratoplasty (PKP) after cultivated oral mucosal epithelial transplantation (COMET) in patients with bilateral total limbal stem cell deficiency (LSCD) due to chemical burn. METHODS: In this prospective interventional nonrandomized case series, optical PKP was performed in patients with severe stromal opacity after successful COMET. Main outcome measures were stability of the ocular surface, visual acuity improvement and corneal graft survival...
August 18, 2017: Ocular Surface
keyword
keyword
66508
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"