Daniela Perotti, Richard D Williams, Jenny Wegert, Jack Brzezinski, Mariana Maschietto, Sara Ciceri, David Gisselsson, Samantha Gadd, Amy L Walz, Rhoikos Furtwaengler, Jarno Drost, Reem Al-Saadi, Nicholas Evageliou, Saskia L Gooskens, Andrew L Hong, Andrew J Murphy, Michael V Ortiz, Maureen J O'Sullivan, Elizabeth A Mullen, Marry M van den Heuvel-Eibrink, Conrad V Fernandez, Norbert Graf, Paul E Grundy, James I Geller, Jeffrey S Dome, Elizabeth J Perlman, Manfred Gessler, Vicki Huff, Kathy Pritchard-Jones
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the 'two-hit' model of tumour development. Since then, the efforts of researchers worldwide have substantially expanded our knowledge of Wilms tumour biology, including major advances in genetics - from cloning the first Wilms tumour gene to high-throughput studies that have revealed the genetic landscape of this tumour. These discoveries improve understanding of the embryonal origin of Wilms tumour, familial occurrences and associated syndromic conditions...
October 17, 2023: Nature Reviews. Urology