Paul J Baker, Andrea C Bohrer, Ehydel Castro, Eduardo P Amaral, Maryonne Snow-Smith, Flor Torres-Juárez, Sydnee T Gould, Artur T L Queiroz, Eduardo R Fukutani, Cassandra M Jordan, Jaspal S Khillan, Kyoungin Cho, Daniel L Barber, Bruno B Andrade, Reed F Johnson, Kerry L Hilligan, Katrin D Mayer-Barber
SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from asymptomatic infection to fatal disease. Co-morbidities, sex, age, host genetics and vaccine status are known to affect disease severity. Yet, how the inflammatory milieu of the lung at the time of SARS-CoV-2 exposure impacts the control of viral replication remains poorly understood. We demonstrate here that immune events in the mouse lung closely preceding SARS-CoV-2 infection significantly impact viral control and we identify key innate immune pathways required to limit viral replication...
March 27, 2024: bioRxiv