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https://www.readbyqxmd.com/read/29767296/evaluating-the-antimicrobial-apoptotic-and-cancer-cell-gene-delivery-properties-of-protein-capped-gold-nanoparticles-synthesized-from-the-edible-mycorrhizal-fungus-tricholoma-crassum
#1
Arpita Basu, Sarmishtha Ray, Supriyo Chowdhury, Arnab Sarkar, Deba Prasad Mandal, Shamee Bhattacharjee, Surekha Kundu
Biosynthesis of gold nanoparticles of distinct geometric shapes with highly functional protein coats without additional capping steps is rarely reported. This study describes green synthesis of protein-coated gold nanoparticles for the first time from the edible, mycorrhizal fungus Tricholoma crassum (Berk.) Sacc. The nanoparticles were of the size range 5-25 nm and of different shapes. Spectroscopic analysis showed red shift of the absorption maxima with longer reaction period during production and blue shift with increase in pH...
May 16, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29765528/metabolic-changes-associated-with-metformin-potentiates-bcl-2-inhibitor-venetoclax-and-cdk9-inhibitor-bay1143572-and-reduces-viability-of-lymphoma-cells
#2
Vineela Chukkapalli, Leo I Gordon, Parameswaran Venugopal, Jeffrey A Borgia, Reem Karmali
Metformin exerts direct anti-tumor effects by activating AMP-activated protein kinase (AMPK), a major sensor of cellular metabolism in cancer cells. This, in turn, inhibits pro-survival mTOR signaling. Metformin has also been shown to disrupt complex 1 of the mitochondrial electron transport chain. Here, we explored the lymphoma specific anti-tumor effects of metformin using Daudi (Burkitt), SUDHL-4 (germinal center diffuse large B-cell lymphoma; GC DLBCL), Jeko-1 (Mantle-cell lymphoma; MCL) and KPUM-UH1 (double hit DLBCL) cell lines...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29730334/fractional-sunburn-threshold-uvr-doses-generate-equivalent-vitamin-d-and-dna-damage-in-skin-types-i-vi-but-with-epidermal-dna-damage-gradient-correlated-to-skin-darkness
#3
Barbara B Shih, Mark D Farrar, Marcus S Cooke, Joanne Osman, Abigail K Langton, Richard Kift, Ann R Webb, Jacqueline L Berry, Rachel E B Watson, Andy Vail, Frank R de Gruijl, Lesley E Rhodes
Public health guidance recommends limiting sun-exposure to sub-sunburn levels, but it's unknown whether these can gain vitamin D (for musculoskeletal health) whilst avoiding epidermal DNA damage (initiates skin cancer). Well-characterised healthy humans of all skin types (I-VI; lightest to darkest skin) were exposed to a low dose-series of solar simulated UVR of 20-80% their individual sunburn threshold dose (minimal erythemal dose, MED). Significant UVR dose-responses were seen for serum 25(OH)D and whole epidermal CPD, with as little as 0...
May 3, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29721382/expression-of-llt1-and-its-receptor-cd161-in-lung-cancer-is-associated-with-better-clinical-outcome
#4
Véronique M Braud, Jérôme Biton, Etienne Becht, Samantha Knockaert, Audrey Mansuet-Lupo, Estelle Cosson, Diane Damotte, Marco Alifano, Pierre Validire, Fabienne Anjuère, Isabelle Cremer, Nicolas Girard, Dominique Gossot, Agathe Seguin-Givelet, Marie-Caroline Dieu-Nosjean, Claire Germain
Co-stimulatory and inhibitory receptors expressed by immune cells in the tumor microenvironment modulate the immune response and cancer progression. Their expression and regulation are still not fully characterized and a better understanding of these mechanisms is needed to improve current immunotherapies. Our previous work has identified a novel ligand/receptor pair, LLT1/CD161, that modulates immune responses. Here, we extensively characterize its expression in non-small cell lung cancer (NSCLC). We show that LLT1 expression is restricted to germinal center (GC) B cells within tertiary lymphoid structures (TLS), representing a new hallmark of the presence of active TLS in the tumor microenvironment...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29721185/an-epigenetic-regulator-related-score-episcore-predicts-survival-in-patients-with-diffuse-large-b-cell-lymphoma-and-identifies-patients-who-may-benefit-from-epigenetic-therapy
#5
Vanessa Szablewski, Caroline Bret, Alboukadel Kassambara, Julie Devin, Guillaume Cartron, Valérie Costes-Martineau, Jérôme Moreaux
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma and shows considerable clinical and biological heterogeneity. Much research is currently focused on the identification of prognostic markers for more specific patients' risk stratification and on the development of therapeutic approaches to improve the long-term outcome. Epigenetic alterations are involved in various cancers, including lymphoma. Interestingly, epigenetic alterations are reversible and drugs to target some of them have been developed...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718932/cancer-growth-and-metastasis-as-a-metaphor-of-go-gaming-an-ising-model-approach
#6
Didier Barradas-Bautista, Matias Alvarado-Mentado, Mark Agostino, Germinal Cocho
This work aims for modeling and simulating the metastasis of cancer, via the analogy between the cancer process and the board game Go. In the game of Go, black stones that play first could correspond to a metaphor of the birth, growth, and metastasis of cancer. Moreover, playing white stones on the second turn could correspond the inhibition of cancer invasion. Mathematical modeling and algorithmic simulation of Go may therefore benefit the efforts to deploy therapies to surpass cancer illness by providing insight into the cellular growth and expansion over a tissue area...
2018: PloS One
https://www.readbyqxmd.com/read/29699594/beneficial-effects-of-curcumin-and-capsaicin-on-cyclophosphamide-induced-premature-ovarian-failure-in-a-rat-model
#7
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin, Nese Basak
BACKGROUND: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model...
April 26, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29696703/mcl1-gene-co-expression-module-stratifies-multiple-myeloma-and-predicts-response-to-proteasome-inhibitor-based-therapy
#8
Ayaz Ali Samo, Jiuyi Li, Min Zhou, Yingyu Sun, Yang Yuan, Yunqiu Zhang, Li Jing, Mark van Duin, Xuzhang Lu, Xiaolong Fan
Multiple myeloma (MM) is the second most common hematologic cancer, characterized by abnormal accumulation of plasma cells in the bone marrow. The extensive biological and clinical heterogeneity of MM hinders effective treatment and etiology research. Several molecular classification systems of prognostic impact have been proposed, but they do not predict the response to treatment nor do they correlate to plasma cell development pathways. Here we describe the classification of MM into two distinct subtypes based on the expression levels of a gene module co-expressed with MCL1 (MCL1-M), a regulator of plasma cell survival...
April 26, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29675597/upregulated-epithelial-junction-expression-represents-a-novel-parameter-of-the-epithelial-radiation-response-to-fractionated-irradiation-in-oral-mucosa
#9
Sylvia Gruber, Nilsu Cini, Lisa-Marie Kowald, Julia Mayer, Andreas Rohorzka, Peter Kuess, Wolfgang Dörr
PURPOSE: During head and neck cancer treatment, the radiation response of the oral mucosa represents a frequent early side effect. Besides radiation-induced inhibition of proliferation, various other cellular responses occur. The radiation response of adherens and tight junction proteins was so far mostly investigated with large single-dose irradiation protocols, in vivo and in vitro. Therefore, the current study was initiated to investigate the impact of daily fractionated irradiation on the expression of adherens and tight junction proteins in vivo...
April 19, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29618356/in-vitro-maturation-of-oocytes-from-excised-ovarian-tissue-in-a-patient-with-autoimmune-ovarian-insufficiency-possibly-associated-with-epstein-barr-virus-infection
#10
Irma Virant-Klun, Andrej Vogler
BACKGROUND: Some reports show that it is possible to isolate immature oocytes from human ovarian tissue retrieved by a cortex biopsy or ovariectomy of non-stimulated ovaries and mature them in vitro. The mature oocytes can be vitrified and stored for in vitro fertilization, which, along with ovarian tissue cryopreservation, is mostly practiced in young cancer patients to preserve their fertility. There is much less data on this new approach in women with a natural ovarian insufficiency, which can be caused by different factors, including viral infection...
April 5, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29602379/-recommendations-for-biomarker-testing-in-epithelial-ovarian-cancer-a-national-consensus-statement-by-the-spanish-society-of-pathology-and-the-spanish-society-of-medical-oncology
#11
Ana Oaknin, Rosa Guarch, Pilar Barretina, David Hardisson, Antonio González-Martín, Xavier Matías-Guiu, Alejandro Pérez-Fidalgo, Begoña Vieites, Ignacio Romero, José Palacios
Advances in the understanding of the histological and molecular characteristics of ovarian cancer now allow 5subtypes to be identified, leading to a more refined therapeutic approach and improved clinical trials. Each of the subtypes has specific histological features and a particular biomarker expression, as well as mutations in different genes, some of which have prognostic and predictive value. CA125 and HE4 are examples of ovarian cancer biomarkers used in diagnosis and follow-up. Currently, somatic or germinal mutations on BRCA1 and BRCA2 genes are the most important biomarkers in epithelial ovarian cancer, having prognostic and predictive value...
April 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29593307/morphology-of-immunomodulation-in-breast-cancer-tumor-draining-lymph-nodes-depends-on-stage-and-intrinsic-subtype
#12
Maximilian Seidl, Moritz Bader, Astrid Vaihinger, Ulrich F Wellner, Rumyana Todorova, Bettina Herde, Klaudia Schrenk, Jochen Maurer, Oliver Schilling, Thalia Erbes, Paul Fisch, Jens Pfeiffer, Linda Hoffmann, Kai Franke, Martin Werner, Peter Bronsert
Cancer research of immune-modulating mechanisms mainly addresses the role of tumor-infiltrating immune cells. Mechanisms modulating the adaptive immune system at the primary activation site - the draining lymph node (LN) - are less investigated. Here we present tumor-caused histomorphological changes in tumor draining LNs of breast cancer patients, dependent on the localization (sentinel LN vs. non-sentinel LN), the tumor size, the intrinsic subtype and nodal metastatic status. The quantitative morphological study was conducted in breast cancer patients with at least one sentinel LN and no neoadjuvant therapy...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29577189/effect-of-various-treatment-modes-of-experimental-mammary-gland-tumor-on-structure-of-anterior-mediastinal-lymph-nodes
#13
O V Kazakov, A V Kabakov, A F Poveshchenko, T V Raiter, D N Strunkin, S S Bogachev, I Yu Ishchenko, A P Lykov, S V Michurina, V I Konenkov
The effects of various treatment modes on the morphology of anterior mediastinal lymph nodes were examined in female Wistar rats with chemically provoked breast cancer. Adjuvant chemotherapy impaired filtration barrier potential of the anterior mediastinal lymph nodes, which manifested in increased volume of sinuses, reduced volumes of lymphoid nodules with germinal centers and thymus-dependent regions, down-regulated proliferative activity of lymphoid cells in B-cell zone and paracortex, and diminished macrophage score in all zones...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29545862/protective-effects-of-amifostine-curcumin-and-caffeic-acid-phenethyl-ester-against-cisplatin-induced-testis-tissue-damage-in-rats
#14
Tolga Mercantepe, Deniz Unal, Levent Tümkaya, Zihni Acar Yazici
Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. The present study was designed to determine the non-oxidative testicular effects caused by the use of cisplatin in rats. The rats were randomly allocated to the experimental groups. The untreated rats represented the control group (group I) and the treatment groups were as follows: cisplatin alone (group II), cisplatin+amifostine (group III), cisplatin+curcumin (group IV), and cisplatin+caffeic acid phenethyl ester (CAPE; group V)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29530952/microrna-17-92-is-required-for-t-cell-and-b-cell-pathogenicity-in-chronic-graft-versus-host-disease-in-mice
#15
Yongxia Wu, Steven Schutt, Katelyn Paz, Mengmeng Zhang, Ryan P Flynn, David Bastian, M Hanief Sofi, Hung Nguyen, Min Dai, Chen Liu, Ying-Jun Chang, Bruce R Blazar, Xue-Zhong Yu
Chronic graft-versus-host disease (cGVHD) is characterized as autoimmune-like fibrosis and antibody production mediated by pathogenic T cells and B cells. MicroRNA-17-92 (miR-17-92) influences the survival, differentiation, and function of lymphocytes in cancer, infections, and autoimmunity. To determine whether miR-17-92 regulates T- and B-cell responses in cGVHD, we generated mice conditionally deficient for miR-17-92 in T cells, B cells, or both. Using murine models of allogeneic bone marrow transplantation, we demonstrate that expression of miR-17-92 in donor T and B cells is essential for the induction of both scleroderma and bronchiolitis obliterans in cGVHD...
April 26, 2018: Blood
https://www.readbyqxmd.com/read/29519565/genomic-analysis-reveals-distinct-subtypes-in-two-rare-cases-of-primary-ovarian-lymphoma
#16
Pallavi Khattar, Puneet Bedi, Marion Gonzalez, Minghao Zhong, Changhong Yin, Weihua Huang, Humayun K Islam, John T Fallon
Primary (localized) non-Hodgkin lymphoma (NHL) of the ovary is extremely rare; only a few cases have been reported in the literature. We report two cases of primary ovarian lymphoma (POL), one involving bilateral ovaries in a 15-year-old girl and other involving one ovary in a 5-year-old girl. This report describes detailed clinical, histopathological, and imaging findings, along with the review of literature of primary diffuse large B-cell lymphoma (DLBCL) arising from an ovary. In addition, we describe findings of targeted capture panel sequencing on both tumors and identify the major genetic mutations that are recurrently mutated in pan-cancers...
April 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29497802/tracer-uptake-in-mediastinal-and-paraaortal-thoracic-lymph-nodes-as-a-potential-pitfall-in-image-interpretation-of-psma-ligand-pet-ct
#17
Ali Afshar-Oromieh, Lars Peter Sattler, Katja Steiger, Tim Holland-Letz, Marcelo Livorsi da Cunha, Walter Mier, Oliver Neels, Klaus Kopka, Wilko Weichert, Uwe Haberkorn
PURPOSE: Since the introduction of 68 Ga-PSMA-11 PET/CT for imaging prostate cancer (PC) we have frequently observed mediastinal lymph nodes (LN) showing tracer uptake despite being classified as benign. The aim of this evaluation was to further analyze such LN. METHODS: Two patient groups with biphasic 68 Ga-PSMA-11 PET/CT at 1 h and 3 h p.i. were included in this retrospective evaluation. Group A (n = 38) included patients without LN metastases, and group B (n = 43) patients with LN metastases of PC...
March 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29485448/fdg-pet-ct-findings-in-a-localized-reactive-lymphoid-hyperplasia-of-the-spleen
#18
Yoshiaki Ito, Tadaki Nakahara, Yuichi Nishihara, Junichi Shiraishi, Masahiro Jinzaki
A 38-year-old man with sigmoid colon cancer underwent a preoperative contrast-enhanced CT which incidentally revealed a modestly enhancing splenic mass. FDG PET/CT showed mildly increased uptake in the splenic lesion in contrast to prominently increased uptake in the colonic tumor. In addition, the splenic mass demonstrated only slightly increased signal intensity in diffusion-weighted MRI, suggesting low probability of metastasis. Splenectomy nonetheless was performed at surgery of the colon cancer. The histopathologic examination showed aggregated lymphoid follicles with germinal centers in the splenic lesion and made the diagnosis of localized reactive lymphoid hyperplasia a rare benign lymphoid tumor...
May 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29459759/genomics-of-a-pediatric-ovarian-fibrosarcoma-association-with-the-dicer1-syndrome
#19
Jorge Melendez-Zajgla, Gabriela E Mercado-Celis, Javier Gaytan-Cervantes, Amada Torres, Nayeli Belem Gabiño, Martha Zapata-Tarres, Luis Enrique Juarez-Villegas, Pablo Lezama, Vilma Maldonado, Karen Ruiz-Monroy, Elvia Mendoza-Caamal
Ovarian fibrosarcomas are extremely rare tumors with little genomic information available to date. In the present report we present the tumoral exome and transcriptome and the germinal exome of an ovarian fibrosarcoma from a 9-years old child. We found a paucity of mutations (0.77/Mb) and CNV alterations. Of these, the most relevant were a point mutation in the metal-binding site of the microRNA-processing DICER1 enzyme and a frame-shift alteration in the tumor suppressor gene NF1. We validated a germinal truncating mutation in DICER1, which was consistent with a DICER1 Syndrome diagnosis, providing the first example of an ovarian fibrosarcoma as the presenting neoplasia in this syndrome...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448960/double-negative-cd27-igd-b-cells-are-expanded-in-nsclc-and-inversely-correlate-with-affinity-matured-b-cell-populations
#20
Sara M Centuori, Cecil J Gomes, Samuel S Kim, Charles W Putnam, Brandon T Larsen, Linda L Garland, David W Mount, Jesse D Martinez
BACKGROUND: The presence of B cells in early stage non-small cell lung cancer (NSCLC) is associated with longer survival, however, the role these cells play in the generation and maintenance of anti-tumor immunity is unclear. B cells differentiate into a variety of subsets with differing characteristics and functions. To date, there is limited information on the specific B cell subsets found within NSCLC. To better understand the composition of the B cell populations found in NSCLC we have begun characterizing B cells in lung tumors and have detected a population of B cells that are CD79A+ CD27- IgD- ...
February 15, 2018: Journal of Translational Medicine
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