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https://www.readbyqxmd.com/read/28910314/the-variability-of-the-steps-preceding-obstacle-avoidance-approach-phase-is-dependent-on-the-height-of-the-obstacle-in-people-with-parkinson-s-disease
#1
Lucas Simieli, Lilian Teresa Bucken Gobbi, Diego Orcioli-Silva, Victor Spiandor Beretta, Paulo Cezar Rocha Santos, André Macari Baptista, Fabio Augusto Barbieri
Gait variability may serve as a sensitive and clinically relevant parameter to quantify adjustments in walking and the changes with aging and neurological disease. Variability of steps preceding obstacle avoidance (approach phase) are important for efficiency in the task, especially in people with Parkinson's disease (PD). However, variability of gait during the approach phase to obstacle avoidance in people with PD has been rarely reported, particularly when ambulating obstacles of different heights. The aim of the present study was to investigate the effects of obstacle height on step-to-step variability (step-to-step variability provides information on the variation between the "equivalent steps" for all trials, and walking variability (indicates the within-step variability of each, providing information about the modulations between the steps performed...
2017: PloS One
https://www.readbyqxmd.com/read/28880414/levodopa-treatment-and-dendritic-spine-pathology
#2
REVIEW
Haruo Nishijima, Tatsuya Ueno, Yukihisa Funamizu, Shinya Ueno, Masahiko Tomiyama
Parkinson's disease (PD) is a neurodegenerative disorder associated with the progressive loss of nigrostriatal dopaminergic neurons. Levodopa is the most effective treatment for the motor symptoms of PD. However, chronic oral levodopa treatment can lead to various motor and nonmotor complications because of nonphysiological pulsatile dopaminergic stimulation in the brain. Examinations of autopsy cases with PD have revealed a decreased number of dendritic spines of striatal neurons. Animal models of PD have revealed altered density and morphology of dendritic spines of neurons in various brain regions after dopaminergic denervation or dopaminergic denervation plus levodopa treatment, indicating altered synaptic transmission...
September 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28877690/gypenosides-ameliorate-memory-deficits-in-mptp-lesioned-mouse-model-of-parkinson-s-disease-treated-with-l-dopa
#3
Ting Ting Zhao, Kyung Sook Kim, Keon Sung Shin, Hyun Jin Park, Hyun Jeong Kim, Kyung Eun Lee, Myung Koo Lee
BACKGROUND: Previous studies have revealed that gypenosides (GPS) improve the symptoms of anxiety disorders in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rat model of Parkinson's disease (PD). The present study aimed to investigate the effects of GPS on memory deficits in an MPTP-lesioned mouse model of PD treated with L-3,4-dihydroxyphenylalanine (L-DOPA). METHODS: MPTP (30 mg/kg/day, 5 days)-lesioned mice were treated with GPS (50 mg/kg) and/or L-DOPA (10 and 25 mg/kg) for 21 days...
September 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28876371/group-climate-in-the-voice-therapy-of-patients-with-parkinson-s-disease
#4
Giovana Diaféria, Glaucya Madazio, Claudia Pacheco, Patricia Barbarini Takaki, Mara Behlau
Purpose: To verify the impact that group dynamics and coaching strategies have on the PD patients voice, speech and communication, as well as the group climate. Methods: 16 individuals with mild to moderate dysarthria due to the PD were divided into two groups: the CG (8 patients), submitted to traditional therapy with 12 regular therapy sessions plus 4 additional support sessions; and the EG (8 patients), submitted to traditional therapy with 12 regular therapy sessions plus 4 sessions with group dynamics and coaching strategies...
September 4, 2017: CoDAS
https://www.readbyqxmd.com/read/28843453/receptor-heteromer-mediated-regulation-of-endocannabinoid-signaling-in-activated-microglia-role-of-cb1-and-cb2-receptors-and-relevance-for-alzheimer-s-disease-and-levodopa-induced-dyskinesia
#5
Gemma Navarro, Dasiel Borroto-Escuela, Edgar Angelats, Íñigo Etayo, Irene Reyes-Resina, Marta Pulido-Salgado, Ana I Rodriguez-Perez, Enric I Canela, Josep Saura, José Luis Lanciego, José Luis Labandeira-García, Carlos A Saura, Kjell Fuxe, Rafael Franco
Endocannabinoids are important regulators of neurotransmission and, acting on activated microglia, they are postulated as neuroprotective agents. Endocannabinoid action is mediated by CB1 and CB2 receptors, which may form heteromeric complexes (CB1-CB2Hets) with unknown function in microglia. We aimed at establishing the expression and signaling properties of cannabinoid receptors in resting and LPS/IFN-γ-activated microglia. Unlike CB1, CB2 receptors and CB1-CB2Hets were upregulated in activated microglia...
August 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28841694/differential-diagnosis-between-parkinson-s-disease-and-essential-tremor-using-the-smartphone-s-accelerometer
#6
Sergi Barrantes, Antonio J Sánchez Egea, Hernán A González Rojas, Maria J Martí, Yaroslau Compta, Francesc Valldeoriola, Ester Simo Mezquita, Eduard Tolosa, Josep Valls-Solè
BACKGROUND: The differential diagnosis between patients with essential tremor (ET) and those with Parkinson's disease (PD) whose main manifestation is tremor may be difficult unless using complex neuroimaging techniques such as 123I-FP-CIT SPECT. We considered that using smartphone's accelerometer to stablish a diagnostic test based on time-frequency differences between PD an ET could support the clinical diagnosis. METHODS: The study was carried out in 17 patients with PD, 16 patients with ET, 12 healthy volunteers and 7 patients with tremor of undecided diagnosis (TUD), who were re-evaluated one year after the first visit to reach the definite diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/28840137/uptake-index-of-123-i-metaiodobenzylguanidine-myocardial-scintigraphy-for-diagnosing-lewy-body-disease
#7
Yoshito Kamiya, Satoru Ota, Shintaro Okumiya, Kosuke Yamashita, Akihiro Takaki, Shigeki Ito
OBJECTIVES: Iodine-123 metaiodobenzylguanidine ((123)I-MIBG) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease (LBD), including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The heart-to-mediastinum ratio (H/M) in PD and DLB is significantly lower than that in Parkinson's plus syndromes and Alzheimer's disease. Although this ratio is useful for distinguishing LBD from non-LBD, it fluctuates depending on the system performance of the gamma cameras...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28835767/passiflora-cincinnata-extract-delays-the-development-of-motor-signs-and-prevents-dopaminergic-loss-in-a-mice-model-of-parkinson-s-disease
#8
Luiz Eduardo Mateus Brandão, Diana Aline Morais Ferreira Nôga, Aline Lima Dierschnabel, Clarissa Loureiro das Chagas Campêlo, Ywlliane da Silva Rodrigues Meurer, Ramón Hypolito Lima, Rovena Clara Galvão Januário Engelberth, Jeferson Souza Cavalcante, Clésio Andrade Lima, Murilo Marchioro, Charles Dos Santos Estevam, José Ronaldo Santos, Regina Helena Silva, Alessandra Mussi Ribeiro
Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28827552/baicalein-prevents-6-ohda-ascorbic-acid-induced-calcium-dependent-dopaminergic-neuronal-cell-death
#9
Sheng-Fang Wang, Liang-Feng Liu, Ming-Yue Wu, Cui-Zan Cai, Huanxing Su, Jieqiong Tan, Jia-Hong Lu, Min Li
6-OHDA plus ascorbic acid (AA) has long been used to induce Parkinson's disease in rodents, while only 6-OHDA is commonly used to induce cell damage in cellular PD models. AA was believed to act as an anti-oxidant to prevent the degradation of 6-OHDA; however, some studies suggested that AA dramatically enhanced the selectivity and toxicity of 6-OHDA. To understand the mechanisms by which 6-OHDA/AA induces cell death, we established a 6-OHDA/AA cell toxicity model in human dopaminergic neuroblastoma SH-SY5Y cells...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28803444/atypical-parkinsonian-syndromes-a-general-neurologist-s-perspective
#10
REVIEW
Angela B Deutschländer, Owen A Ross, Dennis W Dickson, Zbigniew K Wszolek
The differential diagnosis of atypical parkinsonian syndromes is challenging. These severe and often rapidly progressive neurodegenerative disorders are clinically heterogeneous and show significant phenotypic overlap. Here we review clinical, imaging, neuropathologic and genetic features of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and frontotemporal lobar degeneration (FTLD). The terms CBD and FTLD refer to pathologically confirmed cases of corticobasal syndrome (CBS) and frontotemporal dementia (FTD)...
August 12, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28800338/a-guideline-for-parkinson-s-disease-nurse-specialists-with-recommendations-for%C3%A2-clinical-practice
#11
Herma Lennaerts, Marieke Groot, Berna Rood, Koen Gilissen, Hella Tulp, Erik van Wensen, Marten Munneke, Teus van Laar, Bastiaan R Bloem
BACKGROUND: Parkinson's Disease Nurse Specialists (PDNS) play an important role in the care for patients with Parkinson's disease (PD) and their caregivers. Until now, there were no nursing guidelines in PD, and interventions were based solely on daily clinical practice because there is no evidence to support the merits of nursing interventions. Consequently, there is little uniformity in current care delivery. OBJECTIVE: Developing a guideline for PDNS. METHODS: We developed a guideline based on a questionnaire among PDNS and a literature review, supplemented with expert opinion plus the input of patients and caregivers...
August 11, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28799303/clinical-profile-of-dysphagia-in-patients-with-parkinson-s-disease-progressive-supranuclear-palsy-and-multiple-system-atrophy
#12
Sulena, Dipti Gupta, Anjani Kumar Sharma, Baltej Singh
BACKGROUND: Swallowing changes are commonly observed in Parkinson's and Parkinsonism plus syndromes. Expeditious identification is necessary to provide early intervention in this population to avoid risk of aspiration and swallowing complications. OBJECTIVE: To investigate swallowing problems using detailed case history and swallowing speed on 3 ounce water test in three groups i.e. PD, MSA and PSP groups and further, to compare it with control group. SUBJECT AND METHODS: Cross sectional study design...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28776303/premotor-diagnosis-of-parkinson-s-disease
#13
REVIEW
Heinz Reichmann
Typical Parkinsonian symptoms consist of bradykinesia plus rigidity and/or resting tremor. Some time later postural instability occurs. Pre-motor symptoms such as hyposmia, constipation, REM sleep behavior disorder and depression may antecede these motor symptoms for years. It would be ideal, if we had a biomarker which would allow to predict who with one or two of these pre-motor symptoms will develop the movement disorder Parkinson's disease (PD). Thus, it is interesting to learn that biopsies of the submandibular gland or colon biopsies may be a means to predict PD, if there is a high amout of abnormally folded alpha-synuclein and phosphorylated alpha-synuclein...
August 3, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28744873/epicardial-ablation-of-tachyarrhythmia-in-children-experience-at-two-academic-centers
#14
Shailendra Upadhyay, Edward P Walsh, Frank Cecchin, John K Triedman, Juan Villafane, J Philip Saul
BACKGROUND: Experience with percutaneous epicardial ablation of tachyarrhythmia in pediatrics is limited. This case series addresses the feasibility, safety, and complications of the procedure in children. METHODS: A total of nine patients underwent 10 epicardial ablation procedures from 2002 to 2013 at two academic centers. Activation mapping was performed in all cases, and electroanatomic map was utilized in nine of the 10 procedures. Patients had undergone one to three failed endocardial catheter ablations in addition to medical management, and all had symptoms, a high-risk accessory pathway (AP), aborted cardiac arrest with Wolff-Parkinson-White syndrome (WPW), or ventricular dysfunction...
July 26, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28742084/systematic-tissue-specific-functional-annotation-of-the-human-genome-highlights-immune-related-dna-elements-for-late-onset-alzheimer-s-disease
#15
Qiongshi Lu, Ryan L Powles, Sarah Abdallah, Derek Ou, Qian Wang, Yiming Hu, Yisi Lu, Wei Liu, Boyang Li, Shubhabrata Mukherjee, Paul K Crane, Hongyu Zhao
Continuing efforts from large international consortia have made genome-wide epigenomic and transcriptomic annotation data publicly available for a variety of cell and tissue types. However, synthesis of these datasets into effective summary metrics to characterize the functional non-coding genome remains a challenge. Here, we present GenoSkyline-Plus, an extension of our previous work through integration of an expanded set of epigenomic and transcriptomic annotations to produce high-resolution, single tissue annotations...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28729090/the-overlap-between-essential-tremor-and-parkinson-disease
#16
Musleh Algarni, Alfonso Fasano
INTRODUCTION: Essential tremor (ET) and Parkinson's disease (PD) are common disorders especially in the aging population and can have overlapping features that can make it difficult to differentiate between the two. In addition, a possible overlap from a pathophysiological standpoint has been often advocated in the past. METHODS: In this review article, we gather the recent evidence in favor or against a possible relationship between ET and PD. This exercise follows the new advances in the field of tremor from both a pathophysiological and nosological perspective...
July 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28679598/mucuna-pruriens-in-parkinson-disease-a-double-blind-randomized-controlled-crossover-study
#17
RANDOMIZED CONTROLLED TRIAL
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Nicolò G Pozzi, Ioannis U Isaias, Manuela Contin, Michela Barichella, Gianni Pezzoli
OBJECTIVE: To investigate whether Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as alternative source of levodopa for indigent individuals with Parkinson disease (PD) who cannot afford long-term therapy with marketed levodopa preparations. METHODS: We investigated efficacy and safety of single-dose intake of MP powder from roasted seeds obtained without any pharmacologic processing. Eighteen patients with advanced PD received the following treatments, whose sequence was randomized: (1) dispersible levodopa at 3...
August 1, 2017: Neurology
https://www.readbyqxmd.com/read/28676842/subthalamic-nucleus-deep-brain-stimulation-in-early-stage-parkinson-s-disease-is-not-associated-with-increased-body-mass-index
#18
Sarah H Millan, Mallory L Hacker, Maxim Turchan, Anna L Molinari, Amanda D Currie, David Charles
Previous studies suggest that deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease (PD) leads to weight gain. This study analyzes changes in body mass index (BMI) in 29 subjects from a prospective, single-blind trial of DBS in early stage PD (age 50-75, Hoehn & Yahr stage II off medication, treated with antiparkinsonian medications for ≥6 months but <4 years, and without a history of motor fluctuations, dyskinesias, or dementia). Subjects were randomized to DBS plus optimal drug therapy (DBS+ODT; n = 15) or ODT (n = 14) and followed for 24 months...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28668282/brain-infusion-of-%C3%AE-synuclein-oligomers-induces-motor-and-non-motor-parkinson-s-disease-like-symptoms-in-mice
#19
Juliana T S Fortuna, Matthias Gralle, Danielle Beckman, Fernanda S Neves, Luan P Diniz, Paula S Frost, Fernanda Barros-Aragão, Luís E Santos, Rafaella A Gonçalves, Luciana Romão, Daniele C Zamberlan, Felix A A Soares, Carolina Braga, Debora Foguel, Flávia C A Gomes, Fernanda G De Felice, Sergio T Ferreira, Julia R Clarke, Cláudia P Figueiredo
Parkinson's disease (PD) is characterized by motor dysfunction, which is preceded by a number of non-motor symptoms including olfactory deficits. Aggregation of α-synuclein (α-syn) gives rise to Lewy bodies in dopaminergic neurons and is thought to play a central role in PD pathology. However, whether amyloid fibrils or soluble oligomers of α-syn are the main neurotoxic species in PD remains controversial. Here, we performed a single intracerebroventricular (i.c.v.) infusion of α-syn oligomers (α-SYOs) in mice and evaluated motor and non-motor symptoms...
August 30, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28650857/effects-of-transcranial-direct-current-stimulation-plus-physical-therapy-on-gait-in-patients-with-parkinson-disease-a-randomized-controlled-trial
#20
Pattarapol Yotnuengnit, Roongroj Bhidayasiri, Rattana Donkhan, Juthamas Chaluaysrimuang, Krisna Piravej
OBJECTIVE: The aim of the study was to study the combined effects of transcranial direct current stimulation (tDCS) and physical therapy on the walking ability of patients with Parkinson disease (PD). STUDY DESIGN: The study used an experimental, double-blinded, randomized controlled trial. RESULTS: After intervention, group 1 (only tDCS) demonstrated a significant increase in gait speed by 0.13 to 0.14 m/sec (17.8%-19.2%) and an increase in step length by 5...
June 24, 2017: American Journal of Physical Medicine & Rehabilitation
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