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https://www.readbyqxmd.com/read/29925419/follow-up-study-regarding-the-medium-term-effectiveness-of-the-home-visiting-program-pro-kind-at-age-7-years-study-protocol-for-a-randomized-controlled-trial
#1
Sören Kliem, Malte Sandner, Anna Lohmann, Susan Sierau, Verena Dähne, Annette M Klein, Tanja Jungmann
BACKGROUND: Pro Kind is a German adaptation of the US Nurse Family Partnership program. It is an intervention based on home visits targeting first-time mothers from disadvantaged populations. Pro Kind was implemented as a randomized control trial from 2006 to 2012 with N = 755 first-time mothers (TG n = 394, CG n = 391). The 7-8-year follow-up aims to assess the mid-term effects of the program. METHODS/DESIGN: Mid-term outcomes are being assessed by trained assessors...
June 20, 2018: Trials
https://www.readbyqxmd.com/read/29923186/environmental-risk-factors-and-non-pharmacological-non-surgical-interventions-for-obesity-an-umbrella-review-of-meta-analyses-of-cohort-studies-and-randomized-controlled-trials
#2
REVIEW
Marco Solmi, Cristiano A Köhler, Brendon Stubbs, Ai Koyanagi, Beatrice Bortolato, Francesco Monaco, Davy Vancampfort, Myrela O Machado, Michael Maes, Ioanna Tzoulaki, Joseph Firth, John P A Ioannidis, André F Carvalho
BACKGROUND: Multiple environmental factors have been implicated in obesity and multiple interventions, besides drugs and surgery, have been assessed in obese patients. Results are scattered across many studies and meta-analyses and they often mix obese and overweight individuals. MATERIALS AND METHODS: PubMed and Cochrane Database of Systematic Reviews were searched through January 21st , 2017 for meta-analyses of cohort studies assessing environmental risk factors for obesity, and randomized controlled trials investigating non-pharmacological, non-surgical therapeutic interventions for obesity...
June 20, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29921891/management-of-low-and-intermediate-risk-adult-rhabdomyosarcoma-a-pooled-survival-analysis-of-553-patients
#3
Maha A T Elsebaie, Mohamed Amgad, Ahmed Elkashash, Ahmed Saber Elgebaly, Gehad Gamal E L Ashal, Emad Shash, Zeinab Elsayed
This is the second-largest retrospective analysis addressing the controversy of whether adult rhabdomyosarcoma (RMS) should be treated with chemotherapy regimens adopted from pediatric RMS protocols or adult soft-tissue sarcoma protocols. A comprehensive database search identified 553 adults with primary non-metastatic RMS. Increasing age, intermediate-risk disease, no chemotherapy use, anthacycline-based and poor chemotherapy response were significant predictors of poor overall and progression-free survival...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29917225/psychological-treatments-for-adults-and-children-with-epilepsy-evidence-based-recommendations-by-the-international-league-against-epilepsy-psychology-task-force
#4
Rosa Michaelis, Venus Tang, Laura H Goldstein, Markus Reuber, William Curt LaFrance, Tobias Lundgren, Avani C Modi, Janelle L Wagner
Given the significant impact that psychosocial factors and epilepsy treatments can have on the health-related quality of life (HRQOL) of individuals with epilepsy and their families, there is great clinical interest in the role of psychological evaluation and treatments to improve HRQOL and comorbidities. Therefore, the International League Against Epilepsy (ILAE) charged the Psychology Task Force with the development of recommendations for clinical care based on evaluation of the evidence from their recent Cochrane review of psychological treatments in individuals with epilepsy...
June 19, 2018: Epilepsia
https://www.readbyqxmd.com/read/29912070/the-impact-of-massage-and-reading-on-children-s-pain-and-anxiety-after-cardiovascular-surgery-a-pilot-study
#5
Sandra L Staveski, Karen Boulanger, Lee Erman, Li Lin, Christina Almgren, Chloe Journel, Stephen J Roth, Brenda Golianu
OBJECTIVES: The purpose of this pilot study was three-fold: 1) to evaluate the safety and feasibility of instituting massage therapy in the immediate postoperative period after congenital heart surgery, 2) to examine the preliminary results on effects of massage therapy versus standard of care plus three reading visits on postoperative pain and anxiety, and 3) to evaluate preliminary effects of opioid and benzodiazepine exposure in patients receiving massage therapy compared with reading controls...
June 14, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29911511/adherence-in-youth-with-multiple-sclerosis-a-qualitative-assessment-of-habit-formation-barriers-and-facilitators
#6
E Ann Yeh, Nicole Chiang, Bindia Darshan, Nadine Nejati, Stephanie A Grover, Carolyn E Schwartz, Ruth Slater, Marcia Finlayson
Rates of medication nonadherence in youth with multiple sclerosis (MS) range from 10% to 60%. Qualitative studies of adherence can provide insight into children's own perspectives about barriers and facilitators to their adherence and inform future interventions. This qualitative longitudinal descriptive study included children with MS ( n = 28) participating in a randomized controlled trial focused on medication adherence ( clinicaltrials.gov : NCT02234713). Following established methods, three independent reviewers coded transcripts of motivational interviewing (MI) sessions (three interviews per subject, performed monthly over a 3-month period) for relevant themes...
June 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29910631/clonidine-versus-other-adjuncts-added-to-local-anesthetics-for-pediatric-neuraxial-blocks-a-systematic-review-and-meta-analysis
#7
REVIEW
Yang Yang, Ling-Yu Yu, Wen-Sheng Zhang
Background: Clonidine is a common adjunct to local anesthetics for pediatric neuraxial block; however, the pros and cons between clonidine and other adjuncts remain unclear. Thus, we performed this meta-analysis of randomized controlled trials to assess the efficacy and adverse effects between clonidine and other adjuncts added to local anesthetics. Materials and methods: The systematic search, data extraction, critical appraisal, and pooled analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29897851/clinical-trial-of-fluid-infusion-rates-for-pediatric-diabetic-ketoacidosis
#8
Nathan Kuppermann, Simona Ghetti, Jeff E Schunk, Michael J Stoner, Arleta Rewers, Julie K McManemy, Sage R Myers, Lise E Nigrovic, Aris Garro, Kathleen M Brown, Kimberly S Quayle, Jennifer L Trainor, Leah Tzimenatos, Jonathan E Bennett, Andrew D DePiero, Maria Y Kwok, Clinton S Perry, Cody S Olsen, T Charles Casper, J Michael Dean, Nicole S Glaser
BACKGROUND: Diabetic ketoacidosis in children may cause brain injuries ranging from mild to severe. Whether intravenous fluids contribute to these injuries has been debated for decades. METHODS: We conducted a 13-center, randomized, controlled trial that examined the effects of the rate of administration and the sodium chloride content of intravenous fluids on neurologic outcomes in children with diabetic ketoacidosis. Children were randomly assigned to one of four treatment groups in a 2-by-2 factorial design (0...
June 14, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29897540/laser-therapy-for-pediatric-burn-scars-focusing-on-a-combined-treatment-approach
#9
Jennifer Zuccaro, Inga Muser, Manni Singh, Janelle Yu, Charis Kelly, Joel Fish
Treatment with laser therapy has the potential to greatly improve hypertrophic scarring in individuals who have sustained burn injuries. More specifically, recent research has demonstrated the success of using pulsed dye laser therapy to help reduce redness and postburn pruritus and using ablative fractional CO2 laser therapy to improve scar texture and thickness. This study describes our early experience using laser therapy in our pediatric burn program and details our specific treatment approach when using each laser individually and in combination during the same procedure...
April 20, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29895740/kids-safe-and-smokefree-kiss-multilevel-intervention-to-reduce-child-tobacco-smoke-exposure-long-term-results-of-a-randomized-controlled-trial
#10
Stephen J Lepore, Bradley N Collins, Donna L Coffman, Jonathan P Winickoff, Uma S Nair, Beth Moughan, Tyra Bryant-Stephens, Daniel Taylor, David Fleece, Melissa Godfrey
BACKGROUND: Pediatricians following clinical practice guidelines for tobacco intervention (“Ask, Advise, and Refer” [AAR]) can motivate parents to reduce child tobacco smoke exposure (TSE). However, brief clinic interventions are unable to provide the more intensive, evidence-based behavioral treatments that facilitate the knowledge, skills, and confidence that parents need to both reduce child TSE and quit smoking. We hypothesized that a multilevel treatment model integrating pediatric clinic-level AAR with individual-level, telephone counseling would promote greater long-term (12-month) child TSE reduction and parent smoking cessation than clinic-level AAR alone...
June 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29895289/intravenous-morphine-versus-intravenous-paracetamol-after-cardiac-surgery-in-neonates-and-infants-a-study-protocol-for-a-randomized-controlled-trial
#11
Gerdien A Zeilmaker-Roest, Joost van Rosmalen, Monique van Dijk, Erik Koomen, Nicolaas J G Jansen, Martin C J Kneyber, Sofie Maebe, Greet van den Berghe, Dirk Vlasselaers, Ad J J C Bogers, Dick Tibboel, Enno D Wildschut
BACKGROUND: Morphine is worldwide the analgesic of first choice after cardiac surgery in children. Morphine has unwanted hemodynamic and respiratory side effects. Therefore, post-cardiac surgery patients may potentially benefit from a non-opioid drug for pain relief. A previous study has shown that intravenous (IV) paracetamol is effective and opioid-sparing in children after major non-cardiac surgery. The aim of the study is to test the hypothesis that intermittent IV paracetamol administration in children after cardiac surgery will result in a reduction of at least 30% of the cumulative morphine requirement...
June 13, 2018: Trials
https://www.readbyqxmd.com/read/29893947/depression-and-quality-of-life-in-siblings-of-children-with-cancer-after-group-intervention-participation-a-randomized-control-trial
#12
Maru Barrera, Eshetu Atenafu, Paul C Nathan, Fiona Schulte, Kelly Hancock
Objective: The objective of this study was to (1) assess the effects of a group intervention called Siblings Coping Together on siblings' psychosocial adjustment compared with controls; (2) explore the potential moderating effect of siblings' gender; and (3) investigate whether the intervention was more effective for siblings with more depressive symptoms at baseline. Methods: This was a repeated measure, parallel randomized controlled trial (RCT) with two groups...
June 8, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29893932/challenges-in-transitional-care-in-inflammatory-bowel-disease-a-review-of-the-current-literature-in-transition-readiness-and-outcomes
#13
Jessica R Philpott, Jacob A Kurowski
Transitional care for patients with IBD focuses on efforts to successfully transfer care from pediatric to adult providers while encouraging the assumption of health care responsibility. As 25% of patients will be diagnosed with IBD before the age of 18 years, many will undergo this process. Efforts to enhance this process have included transition clinics and other means to improve patient comfort with transition and develop the skill of health care self-management. Currently, most pediatric practitioners provide transition care with informal education and emphasize independence without formal programs...
June 11, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29884144/computer-assisted-rehabilitation-of-attention-in-pediatric-multiple-sclerosis-and-adhd-patients-a-pilot-trial
#14
Marta Simone, Rosa Gemma Viterbo, Lucia Margari, Pietro Iaffaldano
BACKGROUND: The treatment of cognitive deficits is challenging in pediatric onset multiple sclerosis (POMS) and in patients with attention deficit hyperactivity disorder (ADHD). We performed a pilot double-blind RCT to evaluate the efficacy of a home-based computerized-program for retraining attention in two cohorts of POMS and ADHD patients. METHODS: POMS and ADHD patients failing in at least 2/4 attention tests on a neuropsychological battery were randomized to specific or nonspecific computerized training (ST, nST), performed in one-hour sessions, twice/week for 3 months...
June 8, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29875086/dental-home-visits-for-caries-prevention-among-preschool-children-protocol-for-a-cost-effectiveness-analysis-on-a-randomized-control-trial
#15
Niekla Survia Andiesta, Maimunah A Hamid, Kkc Lee, Allan Pau
BACKGROUND: In 2012, nearly 4000 children in Malaysia were referred to hospital pediatric dental services due to dental caries. Recent research has reported the effectiveness of dental home visits in preventing caries development in young children. Dental home visits (DHVs) are described as an ongoing relationship between the dentist and their patients, providing all aspects of a preventive oral health care program in the presence of the parents at home. OBJECTIVE: The objective of this study is to evaluate the cost-effectiveness of dental home visits and oral health information, in the form of educational leaflets, in preventing new caries development in young children, compared to those receiving only educational leaflets over a period of two years...
June 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29872326/mecillinam-for-the-treatment-of-acute-pyelonephritis-and-bacteremia-caused-by-enterobacteriaceae-a-literature-review
#16
REVIEW
Filip Jansåker, Niels Frimodt-Møller, Thomas L Benfield, Jenny Dahl Knudsen
Purpose: The pharmacokinetic properties of mecillinam (MEC) for urinary tract infections are excellent, and the resistance rate in Enterobacteriaceae is low compared to other recommended antibiotics. The oral prodrug pivmecillinam (P-MEC) has been used successfully as first choice for cystitis in the Nordic countries for many years. Norwegian and Danish guidelines also recommend P-MEC for acute uncomplicated pyelonephritis (AUP) and intravenous (IV) MEC for suspected urosepsis (only in Denmark)...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29868390/sustained-impact-of-the-healthy-habits-healthy-girls-brazil-school-based-randomized-controlled-trial-for-adolescents-living-in-low-income-communities
#17
Ana Carolina Barco Leme, Tom Baranowski, Debbe Thompson, Theresa Nicklas, Sonia Tucunduva Philippi
Pediatric obesity is a major public health concern in low- and middle-income countries, such as Brazil. There is an urgent need for preventive programs for adolescents and, the assessment of their sustained impact. This paper reports the longer-term (6-month post intervention) effects of the "H3G-Brazil" obesity prevention program on weight status and weight-related behaviors. A cluster randomized controlled trial starting with 10 public schools in the city of São Paulo, Brazil involved 253 adolescent girls [mean (se) age = 15...
June 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29862490/videolaryngoscopy-versus-direct-laryngoscopy-for-tracheal-intubation-in-neonates
#18
REVIEW
Krithika Lingappan, Jennifer L Arnold, Caraciolo J Fernandes, Mohan Pammi
BACKGROUND: Establishment of a secure airway is a critical part of neonatal resuscitation in the delivery room and the neonatal unit. Videolaryngoscopy has the potential to facilitate successful endotracheal intubation and decrease adverse consequences of delay in airway stabilization. Videolaryngoscopy may enhance visualization of the glottis and intubation success in neonates. OBJECTIVES: To determine the efficacy and safety of videolaryngoscopy compared to direct laryngoscopy in decreasing the time and attempts required for endotracheal intubation and increasing the success rate at first intubation in neonates...
June 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29860223/intravenous-versus-inhalational-anesthesia-for-pediatric-inpatient-surgery-a-systematic-review-and-meta-analysis
#19
REVIEW
Patrick Scheiermann, Friederike Herzog, Andrea Siebenhofer, Reinhard Strametz, Tobias Weberschock
STUDY OBJECTIVE: General anesthesia is commonly used in pediatric inpatient surgery. It can be induced and maintained by either intravenous or volatile anesthetic agents. We aimed to elucidate whether intravenous or volatile anesthetic agents are superior with regards to preventing anesthesia-related complications. DESIGN: Using a predefined standardized study protocol we conducted a systematic review of randomized controlled trials (RCTs) with meta-analysis where appropriate searching the following data bases: CENTRAL, MEDLINE, EMBASE, metaRegister of Controlled Trials (until June 2016)...
May 31, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29857783/efficacy-and-safety-of-fluticasone-propionate-formoterol-fumarate-in-pediatric-asthma-patients-a-randomized-controlled-trial
#20
Anna Płoszczuk, Miroslava Bosheva, Kay Spooner, Tammy McIver, Sanjeeva Dissanayake
BACKGROUND: The efficacy and safety of fluticasone propionate/formoterol fumarate pressurized metered-dose inhaler (pMDI) (fluticasone/formoterol; Flutiform® ; 100/10 µg b.i.d.) was compared with fluticasone propionate (Flixotide® Evohaler® pMDI; 100 µg b.i.d.) and fluticasone/salmeterol (Seretide® Evohaler® pMDI; 100/50 µg b.i.d.) in a pediatric asthma population (EudraCT number: 2010-024635-16). METHODS: A double-blind, double-dummy, parallel group, multicenter study...
January 2018: Therapeutic Advances in Respiratory Disease
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