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https://www.readbyqxmd.com/read/29456086/low-dose-propofol-for-pediatric-migraine-a-prospective-randomized-controlled-trial
#1
David C Sheridan, Matthew L Hansen, Amber L Lin, Rongwei Fu, Garth D Meckler
BACKGROUND: Migraine headaches are a common reason for pediatric emergency department (ED) visits. Small studies suggest the potential efficacy of sub-anesthetic doses of propofol for migraine with a favorable side effect profile and potentially decreased length of stay (LOS). OBJECTIVE: The objective of this study was to compare the efficacy of low-dose propofol (LDP) to standard therapy (ST) in pediatric migraine treatment. METHODS: We conducted a prospective, pragmatic randomized controlled trial from April 2014 through June 2016 in the ED at two pediatric hospitals...
February 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29454009/24-vs-72-hours-of-hypothermia-for-pediatric-cardiac-arrest-a-pilot-randomized-controlled-trial
#2
Ericka L Fink, Robert S B Clark, Rachel P Berger, Anthony Fabio, Derek C Angus, R Scott Watson, John J Gianakas, Ashok Panigrahy, Clifton W Callaway, Michael J Bell, Patrick M Kochaneka
AIM: Children surviving cardiac arrest (CA) lack proven neuroprotective therapies. The role of biomarkers in assessing response to interventions is unknown. We hypothesized that 72 versus 24 h of hypothermia (HT) would produce more favorable biomarker profiles after pediatric CA. METHODS: This single center pilot randomized trial tested HT (33 ± 1 °C) for 24 vs. 72 h in 34 children with CA. Children comatose after return of circulation aged 1 week to 17 years and treated with HT by their physician were eligible...
February 14, 2018: Resuscitation
https://www.readbyqxmd.com/read/29449963/the-nsight1-randomized-controlled-trial-rapid-whole-genome-sequencing-for-accelerated-etiologic-diagnosis-in-critically-ill-infants
#3
Josh E Petrikin, Julie A Cakici, Michelle M Clark, Laurel K Willig, Nathaly M Sweeney, Emily G Farrow, Carol J Saunders, Isabelle Thiffault, Neil A Miller, Lee Zellmer, Suzanne M Herd, Anne M Holmes, Serge Batalov, Narayanan Veeraraghavan, Laurie D Smith, David P Dimmock, J Steven Leeder, Stephen F Kingsmore
Genetic disorders are a leading cause of morbidity and mortality in infants in neonatal and pediatric intensive care units (NICU/PICU). While genomic sequencing is useful for genetic disease diagnosis, results are usually reported too late to guide inpatient management. We performed an investigator-initiated, partially blinded, pragmatic, randomized, controlled trial to test the hypothesis that rapid whole-genome sequencing (rWGS) increased the proportion of NICU/PICU infants receiving a genetic diagnosis within 28 days...
2018: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/29442203/cyclic-vomiting-syndrome-epidemiology-diagnosis-and-treatment
#4
REVIEW
Sanjay Bhandari, Pinky Jha, Abhishek Thakur, Abhipsa Kar, Harrison Gerdes, Thangam Venkatesan
Cyclic-vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder characterized by recurrent episodes of nausea and vomiting. Although once thought to be a pediatric disorder, there has been a considerable increase in recognition of CVS in adults. The exact pathogenesis is unknown and several theories have been proposed. Migraine and CVS share a similar pathophysiology as suggested by several studies. Since there are no specific biomarkers available for this disorder, physicians should rely on Rome criteria for the diagnosis...
February 13, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29439840/randomized-trial-evaluating-the-effectiveness-of-coloring-on-decreasing-anxiety-among-parents-in-a-pediatric-surgical-waiting-area
#5
Elizabeth M Robinson, Rachel Baker, Md Monir Hossain
Anxiety is common among pediatric surgical patients and their parents. Numerous studies have examined interventions to reduce pediatric patients' anxiety; however, less is known about reducing parental anxiety. In other populations, producing art has been shown to significantly reduce anxiety. PURPOSE: This study aimed to determine whether parents' anxiety decreased after coloring while their child is in surgery. DESIGN AND METHODS: A block randomized controlled trial was conducted with a convenience sample of 106 parents of children who were having a scheduled surgery...
February 10, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29437799/high-versus-standard-dose-caffeine-for-apnoea-a-systematic-review
#6
Roos Vliegenthart, Martijn Miedema, Gerard J Hutten, Anton H van Kaam, Wes Onland
BACKGROUND: Placebo-controlled trials have shown that caffeine is highly effective in treating apnoea of prematurity and reduces the risk of bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). OBJECTIVE: To identify, appraise and summarise studies investigating the modulating effect of different caffeine dosages. METHODS: A systematic review identified all randomised controlled trials (RCTs) comparing a high versus a standard caffeine treatment regimen in infants with a gestational age <32 weeks, by searching the main electronic databases and abstracts of the Pediatric Academic Societies...
February 7, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29437489/controller-adherence-following-hospital-discharge-in-high-risk-children-a-pilot-randomized-trial-of-text-message-reminders
#7
Chén C Kenyon, Siobhan M Gruschow, William O Quarshie, Heather Griffis, Michelle C Leach, Joseph J Zorc, Tyra C Bryant-Stephens, Victoria A Miller, Chris Feudtner
OBJECTIVE: To assess the feasibility of a mobile health, inhaled corticosteroid (ICS) adherence reminder intervention and to characterize adherence trajectories immediately following severe asthma exacerbation in high-risk urban children with persistent asthma. METHODS: Children aged 2-13 with persistent asthma were enrolled in this pilot randomized controlled trial during an asthma emergency department (ED) visit or hospitalization. Intervention arm participants received daily text message reminders for 30 days, and both arms received electronic sensors to measure ICS use...
February 13, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29436137/caudal-and-intravenous-dexamethasone-as-an-adjuvant-to-pediatric-caudal-block-a-systematic-review-and-meta-analysis
#8
REVIEW
Change Zhu, Saiji Zhang, Zhiqing Gu, Yiru Tong, Rong Wei
BACKGROUND: Dexamethasone has become a popular additive for regional anesthesia. The aim of this meta-analysis was to assess the effectiveness of this additive on the duration of postoperative analgesia, postoperative vomiting, and possible adverse events in pediatrics. METHODS: We searched databases, conference records, and registered trials for randomized controlled trials. The databases included the Cochrane Library, JBI Database of Systematic Reviews, PubMed, ISI Web of Knowledge, Science-Direct, and Embase...
March 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29432402/performance-under-stress-conditions-during-multidisciplinary-team-immersive-pediatric-simulations
#9
Daniel Aiham Ghazali, Ivan Darmian-Rafei, Stéphanie Ragot, Denis Oriot
OBJECTIVES: The primary objective was to determine whether technical and nontechnical performances were in some way correlated during immersive simulation. Performance was measured among French Emergency Medical Service workers at an individual and a team level. Secondary objectives were to assess stress response through collection of physiologic markers (salivary cortisol, heart rate, the proportion derived by dividing the number of interval differences of successive normal-to-normal intervals > 50 ms by the total number of normal-to-normal intervals [pNN50], low- and high-frequency ratio) and affective data (self-reported stress, confidence, and dissatisfaction), and to correlate them to performance scores...
February 9, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29432315/dexrazoxane-significantly-reduces-anthracycline-induced-cardiotoxicity-in-pediatric-solid-tumor-patients-a-systematic-review
#10
Kelly Liesse, Jamie Harris, Megan Chan, Mary L Schmidt, Bill Chiu
Cardiotoxicity is a dose-limiting and potentially lethal complication of anthracycline administration. Previous studies failed to determine definitive toxic doses or cardioprotective factors. Current dosing strategies may utilize unnecessarily high anthracycline doses, such that survival benefit may not outweigh increased toxicity rates. A systematic review of randomized controlled trials and prospective/retrospective studies investigating anthracycline treatment in pediatric solid tumors was performed from PubMed/MEDLINE and Cochrane databases...
February 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29429908/efficacy-of-artisanal-preparations-of-cannabidiol-for-the-treatment-of-epilepsy-practical-experiences-in-a-tertiary-medical-center
#11
Giulia S Porcari, Cary Fu, Emily D Doll, Emma G Carter, Robert P Carson
Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures. Cannabidiol (CBD), one of many constituents of the Cannabis sativa or marijuana plant, has received renewed interest in the treatment of epilepsy. While highly purified CBD awaits Food and Drug Administration (FDA) approval, artisanal formulations of CBD are readily available and are seeing increased use in our patient population...
February 8, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29427533/utilization-of-a-biomedical-device-veinviewer-%C3%A2-to-assist-with-peripheral-intravenous-catheter-piv-insertion-for-pediatric-nurses
#12
Heidi L McNeely, Theresa L Ream, Jodi M Thrasher, Oliwier Dziadkowiec, Tiffany J Callahan
PURPOSE: Vascular access in pediatric patients can be challenging even with the currently available technological resources. This nurse-driven research study explored time, cost, and resources for intravenous access to determine if a biomedical device, VeinViewer ® Vision, would facilitate improvements in pediatric access. In addition, this study looked at nurse perceptions of skills and confidence around intravenous insertion and if the use of the VeinViewer ® impacted these perceptions...
February 10, 2018: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29409711/phosphocreatine-in-cardiac-surgery-patients-a-meta-analysis-of-randomized-controlled-trials
#13
Fang Mingxing, Giovanni Landoni, Alberto Zangrillo, Fabrizio Monaco, Vladimir V Lomivorotov, Cao Hui, Maxim Novikov, Valery Nepomniashchikh, Evgeny Fominskiy
OBJECTIVE: There is experimental evidence that phosphocreatine (PCr) can decrease ischemia/reperfusion injury of the heart. The authors investigated if PCr would improve heart performance as compared with standard treatment in cardiac surgery. DESIGN: Meta-analysis of randomized controlled trials. SETTING: Hospitals. PARTICIPANTS: Adult and pediatric patients undergoing cardiac surgery. INTERVENTIONS: The ability of PCr to improve cardiac outcomes as compared with standard treatment was investigated...
July 24, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29402570/improving-youth-question-asking-and-provider-education-during-pediatric-asthma-visits
#14
Betsy Sleath, Delesha M Carpenter, Scott A Davis, Claire Hayes Watson, Charles Lee, Ceila E Loughlin, Nacire Garcia, Daniel S Reuland, Gail Tudor
OBJECTIVE: We conducted a pragmatic randomized controlled trial to test the effectiveness of an asthma question prompt list with video intervention to increase youth question-asking and provider education during visits. METHODS: English or Spanish-speaking youth ages 11-17 with persistent asthma and their parents were enrolled from four rural and suburban pediatric clinics. Youth were randomized to the intervention or usual care groups. Intervention group adolescents watched the video on an iPad and then completed an asthma question prompt list before their visits...
January 31, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29395407/can-live-music-therapy-reduce-distress-and-pain-in-children-with-burns-after-wound-care-procedures-a-randomized-controlled-trial
#15
Marianne J E van der Heijden, Johannes Jeekel, Heinz Rode, Sharon Cox, Joost van Rosmalen, Myriam G M Hunink, Monique van Dijk
OBJECTIVE: Burn wound care procedures are very painful and lead to distress. Live music therapy has shown beneficial effects on distress and pain in specific pediatric patient populations. In this study we measured whether live music therapy has beneficial effects in terms of less distress and pain in children with burns after wound care procedures. METHODS: This randomized assessor-blinded controlled trial (RCT) took place at the burns unit of the Red Cross War Memorial Children's Hospital, Cape Town, South Africa...
January 30, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29394482/factors-associated-with-parental-compliance-with-supine-infant-sleep-an-integrative-review
#16
Kristyn Zundo, Elizabeth A Richards, Azza H Ahmed, Jennifer A Codington
Despite educational programs, sudden infant death syndrome (SIDS) rates remain unacceptably high, especially among low-income and African-American populations. The purpose of this review is to examine reasons for parental noncompliance with supine sleep recommendations. A database search in Cochrane Database of Systematic Reviews, PubMed, EBSCOhost, and CINAHL was conducted using keywords SIDS, prevention and control, parental compliance, nursing, supine position, Back to Sleep campaign, and Safe to Sleep campaign...
March 2017: Pediatric Nursing
https://www.readbyqxmd.com/read/29392100/use-of-n-acetylcysteine-in-psychiatric-conditions-among-children-and-adolescents-a-scoping-review
#17
REVIEW
Sadiq Naveed, Afshan Amray, Ahmed Waqas, Amna M Chaudhary, Muhammad W Azeem
N-acetylcysteine (NAC) is a well-known antidote for acetaminophen toxicity and is easily available over the counter. It has antioxidant and anti-inflammatory properties and an established tolerance and safety profile. Owing to its neuroprotective effects, its clinical use has recently expanded to include the treatment of different psychiatric and non-psychiatric disorders. Although a number of randomized controlled trials have documented the clinical evidence for NAC, there are no reviews that summarize the evidence...
November 29, 2017: Curēus
https://www.readbyqxmd.com/read/29390113/long-term-outcomes-after-switching-to-ct-p13-in-pediatric-onset-inflammatory-bowel-disease-a-single-center-prospective-observational-study
#18
Ben Kang, Yoon Lee, Kiwuk Lee, Young Ok Choi, Yon Ho Choe
Background: The relatively high cost and patent expiry of infliximab, an anti-tumor necrosis factor monoclonal antibody used in inflammatory bowel disease (IBD), has led to the development of biosimilar versions of the reference product (RP). This study investigated the long-term efficacy, safety, pharmacokinetics, and immunogenicity of CT-P13 after switching from infliximab RP in pediatric-onset IBD patients. Methods: In this prospective observational study, patients with pediatric-onset IBD receiving maintenance infliximab RP were followed for 1 year after continuing infliximab RP (RP maintenance group) or switching to CT-P13 (CT-P13 switch group)...
January 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29387254/admission-predictability-of-children-with-acute-asthma
#19
Maan Alherbish, Khalid F Mobaireek, Abdullah A Alangari
OBJECTIVES: We aimed to evaluate the seasonal variations of acute asthma presentation in children and the utility of the pediatric asthma score (PAS) and its components in early admission prediction. METHODS: As part of a randomized controlled trial addressing the clinical efficacy of budesonide nebulization in the treatment of acute asthma in children, the PAS was measured at baseline, 1st, 2nd, 3rd, and 4th h from the start of medications. Decision of admission was taken at or beyond the 2nd h...
January 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29382686/reducing-unnecessary-imaging-and-pathology-tests-a-systematic-review
#20
REVIEW
Harriet Hiscock, Rachel Jane Neely, Hayley Warren, Jason Soon, Andrew Georgiou
CONTEXT: Unnecessary imaging and pathology procedures represent low-value care and can harm children and the health care system. OBJECTIVE: To perform a systematic review of interventions designed to reduce unnecessary pediatric imaging and pathology testing. DATA SOURCES: We searched Medline, Embase, Cinahl, PubMed, Cochrane Library, and gray literature. STUDY SELECTION: Studies we included were: reports of interventions to reduce unnecessary imaging and pathology testing in pediatric populations; from developed countries; written in the English language; and published between January 1, 1996, and April 29, 2017...
January 30, 2018: Pediatrics
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