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https://www.readbyqxmd.com/read/29040598/effect-of-metformin-on-vascular-function-in-children-with-type-1-diabetes-a-12-month-randomized-controlled-trial
#1
Jemma J A Anderson, Jennifer J Couper, Lynne C Giles, Catherine E Leggett, Roger Gent, Brian Coppin, Alexia S Peña
Context: Children with type 1 diabetes have vascular dysfunction preceding atherosclerosis. Early interventions are needed to reduce cardiovascular disease. Objective: To evaluate the effect of metformin on vascular function in type 1 diabetes children. Design: 12 month double blind, randomized, placebo-controlled trial. Setting: Tertiary pediatric diabetes clinic. Participants: 90 type 1 diabetes children(8-18 years), above 50th percentile body mass index (BMI)...
October 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29034507/screening-for-sturge-weber-syndrome-a-state-of-the-art-review
#2
REVIEW
Michaela Zallmann, Richard J Leventer, Mark T Mackay, Michael Ditchfield, Philip S Bekhor, John C Su
Infants with a high-risk distribution of port-wine stains are commonly screened for Sturge-Weber syndrome using brain magnetic resonance imaging. There is no consensus about which port-wine stain phenotypes to screen, optimal timing, screening sensitivity, or whether presymptomatic diagnosis improves neurodevelopmental outcomes. This state-of-the-art review examines the evidence in favor of screening for Sturge-Weber syndrome, based on its effect on neurodevelopmental outcomes, against the risks and limitations of screening magnetic resonance imaging and electroencephalography...
October 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29031582/validation-of-a-shortened-version-of-the-children-s-eating-behavior-questionnaire-and-associations-with-bmi-in-a-clinical-sample-of-latino-children
#3
Alma I Behar, Noe C Crespo, Melawhy L Garcia, Guadalupe X Ayala, Nadia Campbell, Lisa M Shadron, John P Elder
OBJECTIVE: To examine the validity of the Children's Eating Behavior Questionnaire (CEBQ) through the associations of its 3 subscale scores (food responsiveness, slowness in eating, and satiety responsiveness) with body mass index (BMI). DESIGN: Cross-sectional study of baseline data from a clinic-based obesity prevention and control randomized controlled trial. PARTICIPANTS: Latino pediatric patients (n = 295) aged 5-11 years from a federally qualified health center in San Diego County, CA, with BMI percentiles ranging from 75...
October 11, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29029149/no-clinical-benefit-of-empirical-antimicrobial-therapy-for-pediatric-diarrhea-in-a-high-usage-high-resistance-setting
#4
Vu Thuy Duong, Ha Thanh Tuyen, Pham Van Minh, James I Campbell, Hoang Le Phuc, Tran Do Hoang Nhu, Le Thi Phuong Tu, Tran Thi Hong Chau, Le Thi Quynh Nhi, Nguyen Thanh Hung, Nguyen Minh Ngoc, Nguyen Thi Thanh Huong, Lu Lan Vi, Corinne N Thompson, Guy E Thwaites, Ruklanthi de Alwis, Stephen Baker
Background: Pediatric diarrheal disease presents a major public health burden in low-middle income countries. The clinical benefits of empirical antimicrobial treatment for diarrhea are unclear in settings that lack reliable diagnostics and have high antimicrobial resistance (AMR). Methods: We conducted a prospective multi-center cross-sectional study of pediatric patients hospitalized with diarrhea containing blood and/or mucus in Ho Chi Minh City, Vietnam. Clinical parameters, including disease outcome and treatment, were measured...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028762/intermittent-versus-continuous-and-intermittent-medications-for-pain-and-sedation-after-pediatric-cardiothoracic-surgery-a-randomized-controlled-trial
#5
Jamie S Penk, Cheryl A Lefaiver, Colleen M Brady, Christine M Steffensen, Kimberly Wittmayer
OBJECTIVES: Compare continuous infusions of morphine and midazolam in addition to intermittent doses with an intermittent only strategy for pain and sedation after pediatric cardiac surgery. DESIGN: Randomized controlled trial. SETTING: Advocate Children's Hospital, Oak Lawn, IL. PATIENTS: Sixty patients 3 months to 4 years old with early extubation after pediatric cardiac surgery. INTERVENTIONS: Patients received a continuous infusion of morphine and midazolam or placebo for 24 hours...
October 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29024184/the-use-of-dipyrone-metamizol-as-an-analgesic-in-children-what-is-the-evidence-a-review
#6
REVIEW
Thomas G de Leeuw, Maaike Dirckx, Antonia Gonzalez Candel, Gail P Scoones, Frank J P M Huygen, Saskia N de Wildt
Dipyrone has analgesic, spasmolytic, and antipyretic effects and is used to treat pain. Due to a possible risk of agranulocytosis with the use of dipyrone, it has been banned in a number of countries. The most commonly used data for the use of dipyrone are related to adults. Information relating to the use of dipyrone in children is scarce. Given the potential added value of dipyrone in the treatment of pain, a review of the literature was conducted to obtain more insight into the analgesic efficacy of dipyrone in children as well as the safety of dipyrone in terms of adverse events...
October 12, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29021235/oral-analgesics-utilization-for-children-with-musculoskeletal-injury-ouch-trial-an-rct
#7
Sylvie Le May, Samina Ali, Amy C Plint, Benoit Mâsse, Gina Neto, Marie-Christine Auclair, Amy L Drendel, Ariane Ballard, Christelle Khadra, Edith Villeneuve, Stefan Parent, Patrick J McGrath, Grégoire Leclair, Serge Gouin
BACKGROUND: Musculoskeletal injuries (MSK-Is) are a common and painful condition among children that remains poorly treated in the emergency department (ED). We aimed to test the efficacy of a combination of an anti-inflammatory drug with an opioid for pain management of MSK-I in children presenting to the ED. METHODS: In this randomized, double-blinded, placebo-controlled trial, we enrolled children between 6 and 17 years presenting to the ED with an MSK-I and a pain score >29 mm on the visual analog scale (VAS)...
October 11, 2017: Pediatrics
https://www.readbyqxmd.com/read/29018940/laparoscopy-or-laparotomy-for-adhesive-bowel-obstruction-in-children-a-systematic-review-and-meta-analysis
#8
Hiromu Miyake, Shogo Seo, Agostino Pierro
PURPOSE: Adhesive small bowel obstruction (ASBO) is one of the most important cause of postoperative morbidity in children who underwent abdominal surgery. Laparoscopic management for ASBO in pediatric patients has been reported. However, its safety and efficacy has not been evaluated in details. The aim of this study is to compare the outcomes of laparoscopy and laparotomy for the treatment of ASBO in children. METHODS: A systematic review and meta-analysis were performed following the Cochrane Handbook for systematic reviews of intervention and the preferred reporting item for systematic reviews and meta-analysis (PRISMA) and a protocol registered in PROSPERO (CRD42017067914)...
October 10, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29018084/oral-morphine-versus-ibuprofen-administered-at-home-for-postoperative-orthopedic-pain-in-children-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Naveen Poonai, Natasha Datoo, Samina Ali, Megan Cashin, Amy L Drendel, Rongbo Zhu, Natasha Lepore, Michael Greff, Michael Rieder, Debra Bartley
BACKGROUND: Oral morphine for postoperative pain after minor pediatric surgery, while increasingly popular, is not supported by evidence. We evaluated whether oral morphine was superior to ibuprofen for at-home management of children's postoperative pain. METHODS: We conducted a randomized superiority trial comparing oral morphine (0.5 mg/kg) with ibuprofen (10 mg/kg) in children 5 to 17 years of age who had undergone minor outpatient orthopedic surgery (June 2013 to September 2016)...
October 10, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28992388/impact-of-nutrition-interventions-on-pediatric-mortality-and-nutrition-outcomes-in-humanitarian-emergencies
#10
REVIEW
Kamna S Balhara, David M Silvestri, W Tyler Winders, Anand Selvam, Sean M Kivlehan, Torben K Becker, Adam C Levine
OBJECTIVES: Malnutrition contributes to pediatric morbidity and mortality in disasters and complex emergencies, but summary data describing specific nutritional interventions in these settings are lacking. This systematic review aims to characterize such interventions and their effects on pediatric mortality, anthropometric measures, and serum markers of nutrition. METHODS: A systematic search of OVID Medline, Cochrane Library, and relevant grey literature was conducted...
October 9, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28992320/effect-of-human-leukocyte-antigen-mismatching-on-the-outcomes-of-pediatric-kidney-transplantation-a-systematic-review-and-meta-analysis
#11
Xinmiao Shi, Rui Liu, Xinfang Xie, Jicheng Lv, Wenke Han, Xuhui Zhong, Jie Ding
Background: Kidney transplantation is regarded as the optimal treatment for pediatric patients with end-stage renal disease. Here, we address a controversial topic in pediatric kidney transplantation by performing a quantitative evaluation of the effect of human leukocyte antigen (HLA) mismatching on the outcomes of pediatric kidney transplantation. Methods: We systematically searched PubMed, EMBASE and the Cochrane Library from their inception to 31 December 2016 for cohort studies assessing the risk ratio (RR) of HLA mismatching on pediatric kidney transplantation...
August 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28989074/safety-of-active-rehabilitation-for-persistent-symptoms-after-pediatric-sport-related-concussion-a-randomized-controlled-trial
#12
Catherine Chan, Grant L Iverson, Jacqueline Purtzki, Kathy Wong, Vivian Kwan, Isabelle Gagnon, Noah D Silverberg
OBJECTIVE: To examine the safety and tolerability of an active rehabilitation program for adolescents who are slow to recover from a sport-related concussion. A secondary objective was to estimate the treatment effect for this intervention. DESIGN: Single-site parallel open-label randomized controlled trial (RCT) comparing treatment as usual (TAU) to TAU plus active rehabilitation. SETTING: Outpatient concussion clinic. PARTICIPANTS: Adolescents aged 12-18 with postconcussion symptoms lasting >1 month after a sports-related concussion...
October 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28986245/applying-interactive-mobile-health-to-asthma-care-in-teens-aim2act-development-and-design-of-a-randomized-controlled-trial
#13
David A Fedele, Andrew McConville, J Graham Thomas, Elizabeth L McQuaid, David M Janicke, Elise M Turner, Jon Moon, Mutasim Abu-Hasan
Early adolescents have difficulties performing asthma self-management behaviors, placing them at-risk for poor asthma control and reduced quality of life. This paper describes the development and plans for testing an interactive mobile health (mHealth) tool for early adolescents, ages 12-15years, and their caregivers to help improve asthma management. Applying Interactive Mobile health to Asthma Care in Teens (AIM2ACT) is informed by the Pediatric Self-management model, which posits that helpful caregiver support is facilitated by elucidating disease management behaviors and allocating treatment responsibility in the family system, and subsequently engaging in collaborative caregiver-adolescent asthma management...
October 3, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28970147/fructans-exacerbate-symptoms-in-a-subset-of-children-with-irritable-bowel-syndrome
#14
B P Chumpitazi, A R McMeans, A Vaughan, A Ali, S Orlando, A Elsaadi, R J Shulman
BACKGROUND & AIMS: Dietary fructans exacerbate symptoms in some, but not all, adults with irritable bowel syndrome (IBS). We sought to determine whether fructans worsen symptoms in children with IBS and whether clinical and psychosocial factors, and/or gas production, can identify those who are fructan sensitive. METHODS: We performed a double-blind placebo-controlled (maltodextrin) cross-over trial of 23 children with IBS, based on pediatric Rome III criteria, from September 2014 through December 2016...
September 29, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28969655/four-level-evaluation-of-health-promotion-intervention-for-preventing-early-childhood-caries-a-randomized-controlled-trial
#15
Leila Basir, Bita Rasteh, Ali Montazeri, Marzieh Araban
BACKGROUND: Early childhood caries (ECC) is the most common dental disease among children, which can affect children's primary teeth during their teething. This study evaluates an intervention for preventing early childhood caries in a pediatric population in Ahvaz, Iran. METHOD: The population of this study (IRCT2017070210804N10) consists of 104 women with 12 to 36 months of age without dental caries referred to a health care center in Ahvaz, Iran. The children were randomly assigned to either an experimental or control group in equal numbers...
October 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28969467/postpartum-depression-when-should-health-care-providers-identify-those-at-risk
#16
Michelle McKean, Aaron B Caughey, Melanie A Yuracko McKean, Michael D Cabana, Valerie J Flaherman
Maternal postpartum depression (PPD) has an impact on mothers and infants. The American Academy of Pediatrics recommends screening for PPD at well-child visits during the first 6 months. We conducted a secondary data analysis of depression screening data collected each month during months 1 to 12 postpartum for 152 mothers with an infant participating in a randomized controlled trial. We used descriptive statistics to describe the incidence and the cumulative incidence of a positive PPD screen during months 1 to 12 postpartum...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28957358/drivers-of-antibiotic-prescribing-in-children-and-adolescents-with-febrile-lower-respiratory-tract-infections
#17
Verena Gotta, Philipp Baumann, Nicole Ritz, Aline Fuchs, Gurli Baer, Jessica M Bonhoeffer, Ulrich Heininger, Gabor Szinnai, Jan Bonhoeffer
BACKGROUND: Knowledge of key drivers for antibiotic prescribing in pediatric lower respiratory tract infection (LRTI) could support rational antibiotic use. Thus, we aimed to determine the impact of clinical and laboratory factors on antibiotic prescribing in children and adolescents with febrile LRTI. METHODS: Pediatric patients from the standard care control group of a randomized controlled trial (ProPAED) investigating procalcitonin guided antibiotic treatment in febrile LRTI were included in a multivariate logistic regression analysis to evaluate the impact of laboratory and clinical factors on antibiotic prescribing...
2017: PloS One
https://www.readbyqxmd.com/read/28954544/two-year-outcomes-of-the-enabling-mothers-to-prevent-pediatric-obesity-through-web-based-education-and-reciprocal-determinism-empower-randomized-control-trial
#18
Adam P Knowlden, Eric Conrad
BACKGROUND: Childhood overweight and obesity is a public health epidemic with far-reaching medical, economic, and quality of life consequences. Brief, web-based interventions have received increased attention for their potential to combat childhood obesity. The purpose of our study was to evaluate a web-based, maternal-facilitated childhood obesity prevention intervention dubbed Enabling Mothers to Prevent Pediatric Obesity Through Web-Based Education and Reciprocal Determinism (EMPOWER), for its capacity to elicit sustained effects at the 2-year postintervention follow-up mark...
September 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28954042/antisecretory-treatment-for-pediatric-gastroesophageal-reflux-disease-a-systematic-review
#19
Ângelo Zambam de Mattos, Gabriela Meirelles Marchese, Bárbara Brum Fonseca, Carlos Kupski, Marta Brenner Machado
BACKGROUND: Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial. Many patients are treated with these drugs for atypical manifestations attributed to gastroesophageal reflux, even that causal relation is not proven. OBJECTIVE: To evaluate the use of proton pump inhibitors and histamine H2 receptor antagonists in pediatric gastroesophageal reflux disease through a systematic review...
September 21, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28953856/effects-of-iron-supplementation-of-low-birth-weight-infants-on-cognition-and-behavior-at-7-years-a-randomized-controlled-trial
#20
Staffan K Berglund, Anna Chmielewska, Josefine Lindberg, Björn Westrup, Bruno Hägglöf, Mikael Norman, Magnus Domellöf
BACKGROUND: Low birth weight infants (LBW) are at increased risk of iron deficiency which has been associated with impaired neurodevelopment. We hypothesized that iron supplementation of LBW infants improve cognitive scores and reduce behavioral problems until school age. METHODS: We randomized 285 marginally LBW (2000-2500 g) infants to receive 0, 1, or 2 mg/kg/day of iron supplements from six weeks to six months of age. At 7 years of age, 205 participants were assessed regarding cognition using Wechsler Intelligence Scale for Children (WISC-IV) and behavior using the parental questionnaires Child Behavior Checklist (CBCL) and Five to Fifteen (FTF)...
September 27, 2017: Pediatric Research
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