Hao-Wei Chang, Evan M Lee, Yi Wang, Cyrus Zhou, Kali M Pruss, Suzanne Henrissat, Robert Y Chen, Clara Kao, Matthew C Hibberd, Hannah M Lynn, Daniel M Webber, Marie Crane, Jiye Cheng, Dmitry A Rodionov, Aleksandr A Arzamasov, Juan J Castillo, Garret Couture, Ye Chen, Nikita P Balcazo, Carlito B Lebrilla, Nicolas Terrapon, Bernard Henrissat, Olga Ilkayeva, Michael J Muehlbauer, Christopher B Newgard, Ishita Mostafa, Subhasish Das, Mustafa Mahfuz, Andrei L Osterman, Michael J Barratt, Tahmeed Ahmed, Jeffrey I Gordon
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, improved weight gain in malnourished Bangladeshi children compared to a more calorically dense standard nutritional intervention. Metagenome-assembled genomes from study participants revealed a correlation between ponderal growth and expression of MDCF-2 glycan utilization pathways by Prevotella copri strains...
March 19, 2024: Nature Microbiology