keyword
https://read.qxmd.com/read/38125642/identification-and-functional-prediction-of-long-non-coding-rna-and-mrna-related-to-connective-tissue-disease-associated-interstitial-lung-diseases
#1
JOURNAL ARTICLE
Fei Dai, Yixi He, Tianyi Lei, Yi Jiang, Quanbo Zhang, Yufeng Qing
OBJECTIVE: Recently, the role of long non-coding RNA (lncRNA) in rheumatic immune diseases has attracted widespread attention. However, knowledge of lncRNA in connective tissue disease-associated interstitial lung disease (CTD-ILD) is limited. This study explored the expression profile and possible mechanisms of lncRNA and mRNA in peripheral blood mononuclear cells (PBMCs) of CTD-ILD patients, especially systemic sclerosis (SSc)-ILD and rheumatoid arthritis (RA)-ILD. METHODS: LncRNA microarray analysis identified 240 diferentially expressed lncRNAs and 218 diferentially expressed mRNA in the CTD-ILD group and the connective tissue disease without associated interstitial lung disease (CTD-NILD) group...
December 2023: Rheumatol Immunol Res
https://read.qxmd.com/read/37637855/nanog-stat-3-and-sox-5-involvement-in-human-fetal-temporomandibular-joint-late-development
#2
JOURNAL ARTICLE
Tacia Catharine Pagni, Juliana Malta da Cunha, Daniel Martinez Saez, Adriana da Costa-Neves, Irina Kerkis, Marcelo Cavenaghi Pereira da Silva
BACKGROUND AND AIM: The temporomandibular joint (TMJ) is a synovial joint that allows the complex movements essential for life. It connects the jawbone to the skull, working as a sliding hinge. Moreover, pluripotent stem cells are a source of precursors and tissue-specific cells in developing organisms, however, their biodistribution in developing fetal tissues is weakly studied. The aim of our study was analyse immunohistochemical expression of Nanog, Oct-4, Sox-2 and Stat-3 and Sox-5, in TMJ tissue samples from human fetuses aged between the 12th and 20th weeks of intrauterine life...
2023: Journal of Oral Biology and Craniofacial Research
https://read.qxmd.com/read/37402068/correction-to-kap1-modulates-osteogenic-diferentiation-via-the-erk-runx2-cascade-in-vascular-smooth-muscle-cells
#3
Weiwei Bai, Meijuan Cheng, Jingjing Jin, Dongxue Zhang, Lanmei Li, Yaling Bai, Jinsheng Xu
No abstract text is available yet for this article.
July 4, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37072271/levothyroxine-suppressive-therapy-in-differentiated-thyroid-cancer-treatment
#4
JOURNAL ARTICLE
Jan Drugda, Jan Čáp, Mikuláš Kosák, Filip Gabalec
Levothyroxine therapy in management of diferentiated thyroid carcinoma (DTC) has been common practice for decades. Levothyroxine is being administered to patiens with DTC after total thyreoidectomy (with or without postopreative radioiodine treatment) not only to restore euthyroidism but to suppress the production of thyroid-stimulating hormone (TSH) as well because TSH is considered as a growth factor for thyroid follicular cells. However there has been a downside to this threatment recently. The main concerns are the known risks related to iatrogenic subclinical or even mild but clinicaly overt iatrogenic hyperthyroidism...
2023: Vnitr̆ní Lékar̆ství
https://read.qxmd.com/read/35472635/ppar%C3%AE-mediates-mangiferin-induced-neuronal-differentiation-of-neural-stem-cells-through-dna-demethylation
#5
JOURNAL ARTICLE
Xiujuan Ye, Yuanfei Wu, Jiamin Xu, Hui Liu, Huan Wang, Qingfeng Li, Qingqing Li, Aiguo Xuan
Adult hippocampal neurogenesis (AHN) is heavily implicated in the pathogenesis of various neuropsychiatric disorders. The mangiferin (MGF), a bioactive compound of the mango, reportedly produces biological effects on a variety of neuropsychiatric disorders. However, the function and underlying mechanisms of MGF in regulating hippocampal neurogenesis remain unknown. Here we discovered that the transcriptome and methylome of MGF-induced neural stem cells (NSCs) are distinct from the control. RNA-seq analysis revealed that the diferentially expressed genes (DEGs) were signifcantly enriched in the PPARs...
April 23, 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/34966628/infective-endocarditis-like-presentation-of-felty-syndrome-a-case-report
#6
Yoji Hoshina, Siale Teaupa, Derek Chang
Felty syndrome (FS) and infective endocarditis (IE) can present with similar signs and symptoms. FS is a diagnosis of exclusion, which poses a challenge for the clinician since accurate diagnosis is required to treat this condition effectively. A 52-year-old woman with a 15-year history of rheumatoid arthritis (RA) was admitted due to dyspnea and pain in the right ankle and left arm for two weeks. She was hemodynamically stable and afebrile. Physical examination revealed right ankle swelling and tenderness, left forearm tenderness, abdominal distension, and swan-neck finger deformities...
December 2021: Curēus
https://read.qxmd.com/read/34459784/metastatic-choriocarcinoma-presenting-as-renal-colic-and-skin-lesion-case-report
#7
JOURNAL ARTICLE
Michał Pietrus, Adrian Czekaj, Dominik Dziadkowiak, Krzysztof Ratajczyk, Maciej Trzciniecki, Paweł Kowal, Yulian Mytsyk
OBJECTIVE: Choriocarcinoma is a rare malignant disease that is usually associated with a gestational event. Kidney metastasis might be misdiagnosed as renal cell carcinoma or kidney abscess. To the best of our knowledge, only 13 cases of cutaneous metastasis of choriocarcinoma have been reported in the literature so far. We report a case of choriocarcinoma that manifested with multiple metastases to the lung, skin, kidney and brain. Case report: We reported a case of a 37-year-old woman with a history of hydatiform mole, with symptoms of renal colic and abnormal findings on the skin...
2021: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/34018357/-role-of-m-6-a-reader-ythdc2-in-differentiation-of-human-bone-marrow-mesenchymal-stem-cells
#8
JOURNAL ARTICLE
Jun-Ru Wen, Zhen Tan, Wei-Min Lin, Qi-Wen Li, Quan Yuan
Objective: To study the regulatory effect of YTH domain-containing protein 2 (YTHDC2), a member of N 6 -methyladenosine (m 6 A) readers, on the osteogenic or adipogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). Methods: YTHDC 2 expression was knocked down by small interfering RNA (siRNA) in vitro . Osteogenic differentiation and adipogenic differentiation of hBMSCs were induced after YTHDC 2 knockdown in order to study the changes in the differentiation phenotype of hBMSCs...
May 2021: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/33154305/neuroendocrine-carcinomas-of-the-breast-case-series-with-review-of-literature
#9
JOURNAL ARTICLE
Vishal Singh, Navpreet Kaur, Shramana Mandal, Varuna Mallya, Reena Tomar, Nita Khurana, Lovenish Bains
Background: The breast tumors with neuroendocrine differentiation show features similar to their counterparts in other organs. Neuroendorine carcinomas account for less than 0.1% of all breast carcinomas. Aims: To study the demographics and clinicopathological prameters ten cases showing neuroendocrine carcinoma breast. Material and Methods: Ten cases showing neuroendocrine carcinoma were studied. The data was analysed for demographics and clinicopathological prameters...
October 2020: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/33067980/-expression-of-adenovirus-mediated-human-clotting-factor-ix-gene-in-mouse-adipose-derived-stem-cells
#10
JOURNAL ARTICLE
Xin Wang, Lin-Hong Wang, Yan-Yan Xie, Jie Li, Zhen-Yu Yan
OBJECTIVE: To investigate the adenovirus-mediated expression of human clotting factor IX (hFIX) gene in mouse adipose-derived stem cells(ADSC). METHODS: The mouse ADSC were isolated and cultured in vitro, the morphology of cells was observed and its growth viability was detected by using CCK-8. Cell surface markers CD29,CD90,CD45 were identified by flow cytometry, and its diferentiation ability was identified by adipogenic and osteogenic induction. Morphological changes was observed and the growth curve should be drawn after transfecting ADSC with adenovirus containing hFIX gene...
October 2020: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/32696636/loss-of-thy-1-may-reduce-lung-regeneration-after-pneumonectomy-in-mice
#11
JOURNAL ARTICLE
Xiaoping Li, Simon S Wong, Chunting Tan, Celia R Espinoza, James S Hagood
BACKGROUND: Lung regeneration plays an important role in lung repair after injury. It is reliant upon proliferation of multiple cell types in the lung, including endothelium, epithelium, and fibroblasts, as well as remodeling of the extracellular matrix. METHODS: Lung regeneration following injury progresses via an initial inflammatory response during which macrophages clear the tissue of cellular debris. This process continues through cellular proliferation when existing cells and progenitors act to repopulate cells lost during injury, followed by tissue maturation in which newly formed cells achieve a differentiated phenotype...
October 2021: Minerva Medica
https://read.qxmd.com/read/32060274/immunoproteasome-expression-is-associated-with-better-prognosis-and-response-to-checkpoint-therapies-in-melanoma
#12
JOURNAL ARTICLE
Shelly Kalaora, Joo Sang Lee, Eilon Barnea, Ronen Levy, Polina Greenberg, Michal Alon, Gal Yagel, Gitit Bar Eli, Roni Oren, Aviyah Peri, Sushant Patkar, Lital Bitton, Steven A Rosenberg, Michal Lotem, Yishai Levin, Arie Admon, Eytan Ruppin, Yardena Samuels
Predicting the outcome of immunotherapy treatment in melanoma patients is challenging. Alterations in genes involved in antigen presentation and the interferon gamma (IFNγ) pathway play an important role in the immune response to tumors. We describe here that the overexpression of PSMB8 and PSMB9, two major components of the immunoproteasome, is predictive of better survival and improved response to immune-checkpoint inhibitors of melanoma patients. We study the mechanism underlying this connection by analyzing the antigenic peptide repertoire of cells that overexpress these subunits using HLA peptidomics...
February 14, 2020: Nature Communications
https://read.qxmd.com/read/30719129/aberrantly-dna-methylated-differentially-expressed-genes-and-pathways-in-hepatocellular-carcinoma
#13
JOURNAL ARTICLE
Changzhou Cai, Weilin Wang, Zhenhua Tu
Background: Methylation plays a significant role in the etiology and pathogenesis of hepatocellular carcinoma (HCC). The aim of the present study is to identify aberrantly methylated-diferentially expressed genes (DEGs) and dysregulated pathways associated with the development of HCC through integrated analysis of gene expression and methylation microarray. Method: Aberrantly methylated-DEGs were identified from gene expression microarrays (GSE62232, GSE74656) and gene methylation microarrays (GSE44909, GSE57958)...
2019: Journal of Cancer
https://read.qxmd.com/read/29778908/mammalian-target-of-rapamycin-complex-2-signaling-in-obese-women-changes-after-bariatric-surgery
#14
JOURNAL ARTICLE
Marcela Augusta de Souza Pinhel, Carolina Ferreira Nicoletti, Natalia Yumi Noronha, Bruno Affonso Parenti de Oliveira, Cristiana Cortes-Oliveira, Wilson Salgado, Wilson Araujo da Silva, Doroteia Rossi Silva Souza, Julio Sergio Marchini, Carla Barbosa Nonino
OBJECTIVES: After bariatric surgery, modifications to signaling pathway networks including those of the metabolic regulator called mammalian or mechanistic target of rapamycin (mTOR) may lead to molecular alterations related to energy source availability, systemic nutrients, and catabolic and anabolic cellular processes. This study aimed to identify gene expression changes with regard to the mTOR complex 2 subunit signaling pathway in obese patients before and after bariatric surgery...
October 2018: Nutrition
https://read.qxmd.com/read/29701396/takayasus-s-aortitis-induced-ascending-aorta-dissection
#15
JOURNAL ARTICLE
Bruno Fernandes, Joana Saraiva, Lina Carvalho
INTRODUCTION: Takayasu aortitis is a well known yet rare form of large vessel vasculitis. Also known as pulseless disease, occlusive thromboaortopathy, and Martorell syndrome, is a chronic inflammatory aortitis. Vessel inflammation leads to wall thickening, fibrosis, stenosis, and thrombus formation. METHODS: A 64-year-old woman was referred to emergency for lack of pulse in the upper and lower limbs and changes in heart rate. AngioRMN revealed dissection of the ascending aorta while in PET, intense uptake of FDG-F18 involving ascending, crossa, descending thoracic and abdominal segments of the aorta, was evident urgent surgical correction occurred...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://read.qxmd.com/read/29688587/galt-carcinoma-three-case-reports-with-glycoprotein-2-immunohistochemistry-and-electron-microscopic-observations
#16
Hiroko Hayashi, Masashi Ohtani, Yuki Sada, Keisuke Iwasaki, Isao Shimokawa
AIMS: Gut-associated lymphoid tissue (GALT) carcinoma is a rare colorectal tumour that arises in the epithelium covering GALT. GALT carcinoma is a differentiated tubular adenocarcinoma with dense lymphoid tissue with a characteristically well-demarcated margin. To date, 26 cases of GALT carcinoma, including the three cases discussed here, have been reported. Most (24 of 26) were discovered at early stages and none of the cases have documented any metastases. This suggests that GALT carcinoma may have a favourable prognosis...
September 2018: Histopathology
https://read.qxmd.com/read/27356893/proteomic-analysis-of-exosomes-and-exosome-free-conditioned-media-from-human-osteosarcoma-cell-lines-reveals-secretion-of-proteins-related-to-tumor-progression
#17
JOURNAL ARTICLE
Sofía Jerez, Héctor Araya, Roman Thaler, M Cristine Charlesworth, Remigio López-Solís, Alexis M Kalergis, Pablo F Céspedes, Amel Dudakovic, Gary S Stein, Andre J van Wijnen, Mario Galindo
Osteosarcomas are the most prevalent bone tumors in pediatric patients, but can also occur later in life. Bone tumors have the potential to metastasize to lung and occasionally other vital organs. To understand how osteosarcoma cells interact with their micro-environment to support bone tumor progression and metastasis, we analyzed secreted proteins and exosomes from three human osteosarcoma cell lines. Exosome isolation was validated by transmission electron microscopy (TEM) and immuno-blotting for characteristic biomarkers (CD63, CD9, and CD81)...
February 2017: Journal of Cellular Biochemistry
https://read.qxmd.com/read/26711214/-relationship-of-gstp1-lower-expression-and-multidrug-resistance-reversing-of-curcumin-on-human-colon-carcinoma-cells
#18
JOURNAL ARTICLE
He Li, Lei Li
OBJECTIVE: To explore the proteomic differences among with and without curcumin treatment of vincristine-resistance HCT-8/VCR cells of human colon carcinoma by using mass spectrometry and two-dimensional gel electrophore-sis (2-DE). METHODS: The total proteins of the both groups were extracted from serum were run in immobilized pH gradient isoelectic focusing (IPG-IEF) at the first dimension.The proteins pots in gels were visualized by silver staining protocol, scanned by using a molecular imager GS-800 calibrated densitometer...
August 11, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/26524029/-role-of-cyclind1-igh-detection-by-fish-in-differential-diagnostic-significance-between-mantle-cell-lymphoma-and-chronic-lymphocytic-leukemia
#19
JOURNAL ARTICLE
Guo-Ping Li, Wan-Zi Chen, Hui-Fang Huang, Jia-Di Chen, Xiao-Lan Lin, Qiang Fu
OBJECTIVE: To investigate the feasibility of CyclinD1/IgH detection by FISH in diferential diagnosis between mantle cell lymphoma (MCL) and chronic lymphocytic leukeamia (CLL). METHODS: The FISH detection was performed for CyclinD1/IgH fusion gene. A comprehensive analysis was carried out for clinical features, such as age, sex , WBC count and lymphocyte count, the bone marrow morphology and immunohistochemical staining were carried for CyclinD1/IgH. RESULTS: It is often difficult to distinguish MCL from CLL by bone marrow morphology, when the cell morphology was not typical; there was no difference in age, sex, WBC count and lymphocyte count between MCL and CLL groups; 9 out of 52 patients were diagnosed as MCL, and the direction of CyclinD1/IgH by FISH was positive in 7 of 9 MCL, while 3 of the 7 patients were negative by immunohistochemical staining for CyclinD1...
October 2015: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/26387386/the-effects-of-tnf-%C3%AE-on-osteogenic-differentiation-of-umbilical-cord-derived-mesenchymal-stem-cells
#20
JOURNAL ARTICLE
Kulisara Marupanthorn, Chairat Tantrawatpan, Duangrat Tantikanlayaporn, Pakpoom Kheolamai, Sirikul Manochantr
Mesenchymal stem cells (MSCs) are multipotent stem cells which are able to differentiate into various lineages including osteoblasts, adipocytes and chondrocytes. They can be isolated from several tissues including bone marrow, adipose tissue, placenta and umbilical cord. Although MSCs could be diferentiated into osteoblasts under appropriate culture condition, their osteogenic differentiation capacity is still not very efficient. Previous studies reported that TNF-α could promote osteogenic differentiation of bone marrow derived MSCs by triggering NF-κB signaling pathway...
April 2015: Journal of the Medical Association of Thailand
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