keyword
https://read.qxmd.com/read/38317371/nurses-priority-setting-for-older-nursing-home-residents-during-covid-19
#21
JOURNAL ARTICLE
My Eklund Saksberg, Therése Bielsten, Suzanne Cahill, Tiny Jaarsma, Ann-Charlotte Nedlund, Lars Sandman, Pier Jaarsma
BACKGROUND: Ethical principles behind prioritization in healthcare are continuously relevant. However, applying ethical principles during times of increased need, such as during the COVID-19 pandemic, is challenging. Also, little is known about nursing home nurses' prioritizations in their work to achieve well-being and health for nursing home residents. AIM: The aim of this study was to explore nursing home nurses' priority-setting for older nursing home residents in Sweden during the COVID-19 pandemic...
February 5, 2024: Nursing Ethics
https://read.qxmd.com/read/38314058/gonadotropin-releasing-hormone-agonist-gnrha-during-chemotherapy-and-post-cancer-childbirths-a-nationwide-population-based-cohort-study-of-24-922-women-diagnosed-with-cancer-in-sweden
#22
JOURNAL ARTICLE
Kenny A Rodriguez-Wallberg, Helle Kieler, Theodoros Foukakis, Jiong Li, Mika Gissler, Anna Sara Oberg, Jonas Bergh, Frida E Lundberg
BACKGROUND: Worldwide, an increasing number of women with cancer are receiving Gonadotropin Releasing Hormone agonist (GnRHa) co-treatment during chemotherapy aiming at ovarian protection. There is divergence among guidelines, and some have recommended GnRHa co-treatment for women with breast cancer, however, the effect of GnRHa on future fertility is uncertain. METHODS: In this population-based cohort study we included all women diagnosed with cancer at ages 15-45 between July 2005 and March 2017 in Sweden, identified in the Swedish Cancer Register...
January 2024: EClinicalMedicine
https://read.qxmd.com/read/38309755/biomel-a-translational-research-biobank-of-melanocytic-lesions-and-melanoma
#23
JOURNAL ARTICLE
Teo Helkkula, Gustav Christensen, Christian Ingvar, Karolin Isaksson, Katja Harbst, Bertil Persson, Åsa Ingvar, Anna Hafström, Ana Carneiro, Viktoria Gaspar, Göran Jönsson, Kari Nielsen
INTRODUCTION: Diagnosing invasive cutaneous melanoma (CM) can be challenging due to subjectivity in distinguishing equivocal nevi, melanoma in situ and thin CMs. The underlying molecular mechanisms of progression from nevus to melanoma must be better understood. Identifying biomarkers for treatment response, diagnostics and prognostics is crucial. Using biomedical data from biobanks and population-based healthcare data, translational research can improve patient care by implementing evidence-based findings...
February 2, 2024: BMJ Open
https://read.qxmd.com/read/38277096/comprehensive-geriatric-assessment-as-an-essential-tool-to-register-or-update-dnr-codes-in-a-tertiary-care-hospital
#24
JOURNAL ARTICLE
Veerle Mertens, Charlotte Cottignie, Mick van de Wiel, Maurits Vandewoude, Stany Perkisas, Ella Roelant, Greta Moorkens, Guy Hans
PURPOSE: To investigate the prevalence of Do not Resuscitate (DNR) code registration in patients with a geriatric profile admitted to Antwerp University Hospital, a tertiary care hospital in Flanders, Belgium, and the impact of comprehensive geriatric assessment (CGA) on DNR code registration. PATIENTS AND METHODS: Retrospective analysis of a population of 543 geriatric patients (mean age 82.4 ± 5.19 years, 46.4% males) admitted to Antwerp University Hospital from 2018 to 2020 who underwent a CGA during admission...
January 26, 2024: European Geriatric Medicine
https://read.qxmd.com/read/38254265/the-effects-of-signal-to-noise-ratio-t60-wide-dynamic-range-compression-speed-and-digital-noise-reduction-in-a-virtual-restaurant-setting
#25
JOURNAL ARTICLE
Gregory M Ellis, Jeff Crukley, Pamela E Souza
OBJECTIVES: Hearing aid processing in realistic listening environments is difficult to study effectively. Often the environment is unpredictable or unknown, such as in wearable aid trials with subjective report by the wearer. Some laboratory experiments create listening environments to exert tight experimental control, but those environments are often limited by physical space, a small number of sound sources, or room absorptive properties. Simulation techniques bridge this gap by providing greater experimental control over listening environments, effectively bringing aspects of the real-world into the laboratory...
January 23, 2024: Ear and Hearing
https://read.qxmd.com/read/38249654/knowledge-and-attitudes-regarding-do-not-resuscitate-decisions-among-clinical-year-medical-students-and-interns-in-the-western-region-of-saudi-arabia
#26
JOURNAL ARTICLE
Hasan Z Binjabi, Mohammed H Alturki, Abdulaziz A Almtrfi, Abdullah A Qashar, Abdullah M Alobedi, Hazem M Aljabri, Abdulaziz O Babukur, Muhanna M Almatrafi, Rayan O Almalki, Mohammad S Dairi
Background The directive to withhold emergent interventions in the case of cardiac and/or respiratory arrest with the continuation of standard care and therapy is known as do-not-resuscitate (DNR). The diversity of DNR guidelines depends on moral and religious factors. In Saudi Arabia, a DNR policy was published in 2017 which corresponds to the religious and ethical aspects of Islamic law. To augment future awareness regarding DNR decisions, as they are an essential element in critical care medicine, the foundational principles of DNR must be provided during the clinical years of medical school...
January 2024: Curēus
https://read.qxmd.com/read/38241857/self-assembly-of-copper-nanoclusters-using-dna-nanoribbon-templates-for-sensitive-electrochemical-detection-of-h-2-o-2-in-live-cells
#27
JOURNAL ARTICLE
Lan Luo, Yukun Xing, Yue Fu, Le Li, Xinya Yang, Yumiao Xue, Jing Luo, Huaiyu Bu, Fangfang Chen, Xiangyuan Ouyang
The excessive secretion of H2 O2 within cells is closely associated with cellular dysfunction. Therefore, high sensitivity in situ detection of H2 O2 released from living cells was valuable in clinical diagnosis. In the present work, a novel electrochemical cells sensing platform by synthesizing copper nanoclusters (CuNCs) at room temperature based on DNA nanoribbon (DNR) as a template (DNR-CuNCs). The tight and ordered arrangement of nanostructured assemblies of DNR-CuNCs conferred the sensor with superior stability (45 days) and electrochemical performance...
January 5, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38237264/small-animal-veterinary-clients-prefer-veterinarians-to-decide-when-to-terminate-resuscitation-and-to-be-informed-after-cardiopulmonary-resuscitation-efforts
#28
JOURNAL ARTICLE
Leonie Bertram, Kendon Kuo, Erik Hofmeister, Katherine Gerken
OBJECTIVE: To identify the preferences of small animal veterinary clients for the timing of communication during CPR and whether these clients prefer the veterinarian or pet owner to decide on the termination of resuscitation. SAMPLE: Surveys (n = 1,648) were completed between January 20 and February 3, 2023, by clients of the Wilford and Kate Bailey Small Animal Teaching Hospital. METHODS: This cross-sectional observational study used an anonymous internet-based survey distributed to 28,000 clients of an academic small animal veterinary hospital...
January 19, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38232707/interventions-performed-in-children-with-immunocompromised-conditions-in-the-pediatric-intensive-care-unit-within-48-hours-of-death
#29
JOURNAL ARTICLE
Anna Kegel, Jason Espinoza, April Rahrig, Tina Schade-Wills, Courtney M Rowan
Background: Understanding interventions preceding death in children with immunocompromised conditions is important to ensure a peaceful and dignified perideath experience. The aim of this study was to describe the number of interventions performed in the pediatric intensive care unit (PICU) within the 48 hours before death in this population. Methods: This was a single-center, retrospective cohort study of all children with an underlying oncologic, hematologic, or immunologic diagnosis admitted to the PICU for at least 72 hours between 2014 and 2021...
January 17, 2024: Journal of Palliative Medicine
https://read.qxmd.com/read/38185059/the-rac1-inhibitor-ehop-016-attenuates-aml-cell-migration-and-enhances-the-efficacy-of-daunorubicin-in-molm-13-transplanted-zebrafish-larvae
#30
JOURNAL ARTICLE
Anette Lodvir Hemsing, Jan-Lukas Førde, Håkon Reikvam, Lars Herfindal
Ras-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase implicated in cell migration and homing of hematopoietic cells to the hematopoietic niche, and is commonly overexpressed in acute myeloid leukemia (AML). This can lead to quiescence of leukemic blasts in the niche and reduced response to therapy. We investigated the Rac1 inhibitor EHop-016 on AML by assessing its effects on MOLM-13 cells in vitro and in zebrafish larvae, regarding cell motility and therapeutic potential in combination with daunorubicin (DNR)...
January 5, 2024: Translational Oncology
https://read.qxmd.com/read/38173485/sensitive-determination-of-daunorubicin-in-plasma-of-children-with-leukemia-using-ph-switchable-deep-eutectic-solvents-and-hplc-uv-analysis
#31
JOURNAL ARTICLE
Reza Akramipour, Homa Babaei, Fiedel Castru-Cayllaha, Mohammad Reza Golpayegani, Nazir Fattahi, Farshad Fattahi
An environmental friendly, fast, easy and inexpensive liquid-liquid microextraction (LLME) in combination with pH-switchable deep eutectic solvent (DES) method followed by HPLC was investigated for the separation and determination of daunorubicin (DNR) in human plasma samples. For this purpose, first, 9 DESs were prepared based on previous studies and their switchability in aqueous solution was evaluated by changing the pH. Non-switchable DESs were discarded and switchable DESs were used to extract DNR. The parameters affecting the extraction efficiency were optimized (DES type, volume of DES, concentration of KOH, volume of HCl, salt addition and extraction time)...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38152565/do-not-resuscitatedecision-making-during-the-covid-19-pandemic-in-a-teaching-hospital-lessons-learned-for-the-future
#32
JOURNAL ARTICLE
Mick van de Wiel, Sabrina van Ierssel, Walter Verbrugghe, Veerle Mertens, Annelies Janssens
METHOD: A cross-sectional survey study was conducted between February 2021 and April 2021 for all doctors and doctors in training, working in the Antwerp University Hospital during the COVID-19 pandemic. RESULTS: 127 doctors participated in this study. The familiarity with the different scores used in the triage during the COVID-10 pandemic was 51% for the Clinical Frailty Scale (CFS) and 20% for the Charlson Comorbidity Index (CCI). Participants indicated that their DNR decision is based on various aspects such as clinical assessment, comorbidities, patient's wishes, age, prognosis, and functional state...
2023: Journal of Aging Research
https://read.qxmd.com/read/38150077/the-impact-of-a-multidisciplinary-goals-of-care-program-on-unplanned-readmission-rates-at-a-comprehensive-cancer-center
#33
JOURNAL ARTICLE
Cerena Leung, Clark R Andersen, Kaycee Wilson, Nico Nortje, Marina George, Christopher Flowers, Eduardo Bruera, David Hui
PURPOSE: This study examined the 30-day unplanned readmission rate in the medical oncology population before and after the implementation of an institution-wide multicomponent interdisciplinary goals of care (myGOC) program. METHODS: This retrospective study compared the 30-day unplanned readmission rates in consecutive medical patients during the pre-implementation period (May 1, 2019, to December 31, 2019) and the post-implementation period (May 1, 2020, to December 31, 2020)...
December 27, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/38126404/discussion-of-the-do-not-resuscitate-dnr-orders-with-the-family-caregivers-of-cancer-patients-an-example-from-a-major-cancer-center-in-saudi-arabia
#34
JOURNAL ARTICLE
Mohammad Z Al-Shahri, Mahmoud Sroor, Wael Ali Said Ghareeb, Suzan Alhassanin, Heba Aly Ateya
OBJECTIVES: To explore the views of the family caregivers (FCGs) about the "do-not-resuscitate" (DNR) discussions and decision-making processes that occurred during hospitalization in a Saudi cancer center. METHODS: In this cross-sectional survey, the FCGs of inpatients with advanced cancer completed a self-administered questionnaire soon after giving the patients a DNR status designation by their oncologists. RESULTS: Eighty-two FCGs participated in the study, with a median age of 36...
December 21, 2023: Palliative & Supportive Care
https://read.qxmd.com/read/38111223/in-hospital-code-status-updates-trends-over-time-and-the-impact-of-covid-19
#35
JOURNAL ARTICLE
Amirreza Sahebi-Fakhrabad, Eda Kemahlioglu-Ziya, Robert Handfield, Stacy Wood, Mehul D Patel, Cristen P Page, Lydia Chang
OBJECTIVE: The primary objective was to evaluate if the percentage of patients with missing or inaccurate code status documentation at a Trauma Level 1 hospital could be reduced through daily updates. The secondary objective was to examine if patient preferences for DNR changed during the COVID-19 pandemic. METHODS: This retrospective study, spanning March 2019 to December 2022, compared the code status in ICU and ED patients drawn from two data sets. The first was based on historical electronic medical records (EHR), and the second involved daily updates of code status following patient admission...
December 18, 2023: American Journal of Hospice & Palliative Care
https://read.qxmd.com/read/38087874/retrospective-review-of-the-code-status-of-individuals-with-down-syndrome-during-the-covid-19-era
#36
JOURNAL ARTICLE
Jennifer Jett, Alexander Fossi, Heather Blonsky, Wendy Ross, Sabra Townsend, Mary M Stephens, Brian Chicoine, Stephanie L Santoro
Code status is a label in the medical record indicating a patient's wishes for end-of-life (EOL) care in the event of a cardiopulmonary arrest. People with intellectual disabilities had a higher risk of both diagnosis and mortality from coronavirus infections (COVID-19) than the general population. Clinicians and disability advocates raised concerns that bias, diagnostic overshadowing, and ableism could impact the allocation of code status and treatment options, for patients with intellectual disabilities, including Down syndrome (DS)...
December 12, 2023: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://read.qxmd.com/read/38087000/unlabelled-lret-biosensor-based-on-double-stranded-dna-for-the-detection-of-anthraquinone-anticancer-drugs
#37
JOURNAL ARTICLE
Wenhui He, Zhiwei Chen, Chunxiao Yu, Yiping Shen, Dongzhi Wu, Nannan Liu, Xi Zhang, Fang Wu, Jinghua Chen, Tao Zhang, Jianming Lan
Based on upconversion nanoparticles (UCNPs) as energy donor and herring sperm DNA (hsDNA) as molecular recognition element, an unlabelled upconversion luminescence (UCL) affinity biosensor was constructed for the detection of anthraquinone (AQ) anticancer drugs in biological fluids. AQ anticancer drugs can insert into the double helix structure of hsDNA on the surface of UCNPs, thereby shortening the distance from UCNPs. Therefore, the luminescence resonance energy transfer (LRET) phenomenon is effectively triggered between UCNPs and AQ anticancer drugs...
December 13, 2023: Mikrochimica Acta
https://read.qxmd.com/read/38081665/socially-sustainable-housing-and-built-environments-to-support-the-health-and-social-inclusion-of-older-adults-protocol-for-a-scoping-review-and-stakeholder-consultation
#38
JOURNAL ARTICLE
Jodi Sturge, Elke Miedema, Marie Elf, Susanna Nordin
INTRODUCTION: Housing and the ageing population are issues that pose challenges for social, health and economic policies. Therefore, there is a need for more knowledge on how to design housing and public infrastructure to improve the social engagement and well-being of older adults who age in place. This project aims to provide an overview of the existing literature on design features that support socially sustainable living environments for older adults. METHODS AND ANALYSIS: A systematic scoping methodology was used to identify and summarise the findings...
December 11, 2023: BMJ Open
https://read.qxmd.com/read/38070906/profertil-study-protocol-for-the-investigation-of-gonadotropin-releasing-hormone-agonists-gnrha-during-chemotherapy-aiming-at-fertility-protection-of-young-women-and-teenagers-with-cancer-in-sweden-a-phase-iii-randomised-double-blinded-placebo-controlled-study
#39
JOURNAL ARTICLE
Kenny A Rodriguez-Wallberg, Hanna Pauline Nilsson, Jonas Bergh, Johan Malmros, Per Ljungman, Theodoros Foukakis, Christina Linder Stragliotto, Erika Isaksson Friman, Barbro Linderholm, Antonis Valachis, Anne Andersson, Sara Harrysson, Lovisa Vennström, Per Frisk, Helena Mörse, Sandra Eloranta
BACKGROUND: Gonadotropin-releasing hormone agonists (GnRHa) cotreatment used to transiently suppress ovarian function during chemotherapy to prevent ovarian damage and preserve female fertility is used globally but efficacy is debated. Most clinical studies investigating a beneficial effect of GnRHa cotreatment on ovarian function have been small, retrospective and uncontrolled. Unblinded randomised studies on women with breast cancer have suggested a beneficial effect, but results are mixed with lack of evidence of improvement in markers of ovarian reserve...
December 9, 2023: BMJ Open
https://read.qxmd.com/read/38020856/initiating-advance-care-planning-at-admission-a-brief-intervention-to-increase-goals-of-care-discussions-in-geriatric-trauma-patients-in-an-urban-level-i-trauma-center
#40
JOURNAL ARTICLE
Franchesca Hwang, Joohee Son, Kelsey Ensor, Nicole Goulet, Allison Brown, Jesse Victory, Leslie Tyrie
OBJECTIVES: The burden of geriatric trauma continues to rise. Older trauma patients experience higher morbidity and mortality and thus benefit from early goals of care (GOC) discussions and advance care planning (ACP). The American College of Surgeons (ACS) Trauma Quality Improvement Program (TQIP) recommends holding a family meeting within 72 hours of admission when treating geriatric trauma patients. At our level I trauma center, we sought to increase early GOC discussions by implementing a new history and physical (H&P) note template for geriatric trauma patients...
2023: Trauma Surgery & Acute Care Open
keyword
keyword
6648
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.