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https://www.readbyqxmd.com/read/29146561/recurrent-neural-networks-with-specialized-word-embeddings-for-health-domain-named-entity-recognition
#1
Iñigo Jauregi Unanue, Ehsan Zare Borzeshi, Massimo Piccardi
BACKGROUND: Previous state-of-the-art systems on Drug Name Recognition (DNR) and Clinical Concept Extraction (CCE) have focused on a combination of text "feature engineering" and conventional machine learning algorithms such as conditional random fields and support vector machines. However, developing good features is inherently heavily time-consuming. Conversely, more modern machine learning approaches such as recurrent neural networks (RNNs) have proved capable of automatically learning effective features from either random assignments or automated word "embeddings"...
November 13, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29136793/electrochemical-monitoring-of-the-interaction-between-anticancer-drug-and-dna-in-the-presence-of-antioxidant
#2
Merve Muti, Mihrican Muti
The aim of this work is to find out the effect of antioxidant onto the interaction of DNA-anticancer drug, daunorubicin. Daunorubicin (DNR) is an anti-cancer drug which is used for the treatment of certain cancers including the treatment of leukemia. The treatments of patients, who suffer from cancer, become generally complicated if they take some antioxidant-containing supplement during chemotherapy. In this study, the interaction performance between DNR and DNA was investigated both in the presence and absence of antioxidant, caffeic acid, as the first time in the literature...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29129249/association-between-hospital-rates-of-early-do-not-resuscitate-orders-and-favorable-neurological-survival-among-survivors-of-inhospital-cardiac-arrest
#3
Timothy J Fendler, John A Spertus, Kevin F Kennedy, Paul S Chan
BACKGROUND: Current guidelines recommend deferring prognostication for 48 to 72 hours after resuscitation from inhospital cardiac arrest. It is unknown whether hospitals vary in making patients who survive an arrest Do-Not-Resuscitate (DNR) early after resuscitation and whether a hospital's rate of early DNR is associated with its rate of favorable neurological survival. METHODS: Within Get With the Guidelines-Resuscitation, we identified 24,899 patients from 236 hospitals who achieved return of spontaneous circulation (ROSC) after inhospital cardiac arrest between 2006 and 2012...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/29101301/do-not-attempt-resuscitation-dnar-orders-understanding-and-interpretation-of-their-use-in-the-hospitalised-patient-in-ireland-a-brief-report
#4
Helen O'Brien, Siobhan Scarlett, Anne Brady, Kieran Harkin, Rose Anne Kenny, Jeanne Moriarty
Following the introduction of do-not-resuscitate (DNR) orders in the 1970s, there was widespread misinterpretation of the term among healthcare professionals. In this brief report, we present findings from a survey of healthcare professionals. Our aim was to examine current understanding of the term do-not-attempt-resuscitate (DNAR), decision-making surrounding DNAR and awareness of current guidelines. The survey was distributed to doctors and nurses in a university teaching hospital and affiliated primary care physicians in Dublin via email and by hard copy at educational meetings from July to December 2014...
November 3, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29070105/-embelin-reverses-the-multi-drug-resistance-of-k562-d-to-daunorubicin-independently-of-p-gp-and-mdr1-mrna
#5
Hui-Nan Jiang, Zhuo-Gang Liu, Rong Hu
OBJECTIVE: To investigate the mechanism of reversing drug resistance of K562/D cells to daunorubicin by Embelin and its relationship with P-gp and MDR1 mRNA. METHODS: MTT assay was used to detect and compare the cell proliferation rate of treating with DNR alone and DNR combined with Embelin. Flow cytometry with Annexin V-FITC/PI double staining was used to detect cell apoptosis rate, Western blot was used to detect the expression of XIAP,Caspase-3,BCL-2,BAX and P-gp of K562/D cells after using DNR alone and combining with Embelin...
October 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29044457/secondary-prevention-medication-use-after-myocardial-infarction-in-u-s-nursing-home-residents
#6
Andrew R Zullo, Sadia Sharmin, Yoojin Lee, Lori A Daiello, Nishant R Shah, W John Boscardin, David D Dore, Sei J Lee, Michael A Steinman
BACKGROUND/OBJECTIVES: Secondary prevention medications are recommended for older adults after acute myocardial infarction (AMI), but little is known about whether nursing home (NH) residents receive these medications. The objective was to evaluate new use of secondary prevention medications after AMI in NH residents who were previously nonusers and to evaluate what factors were associated with use. DESIGN: Retrospective cohort using linked national Minimum Data Set assessments; Online Survey, Certification and Reporting records; and Medicare claims...
November 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29042684/a-single-point-mutation-in-class-iii-ribonucleotide-reductase-promoter-renders-pseudomonas-aeruginosa-pao1-inefficient-for-anaerobic-growth-and-infection
#7
Anna Crespo, Joan Gavaldà, Esther Julián, Eduard Torrents
Pseudomonas aeruginosa strain PAO1 has become the reference strain in many laboratories. One enzyme that is essential for its cell division is the ribonucleotide reductase (RNR) enzyme that supplies the deoxynucleotides required for DNA synthesis and repair. P. aeruginosa is one of the few microorganisms that encodes three different RNR classes (Ia, II and III) in its genome, enabling it to grow and adapt to diverse environmental conditions, including during infection. In this work, we demonstrate that a lack of RNR activity induces cell elongation in P...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29039532/puerarin-attenuates-the-daunorubicin-induced-apoptosis-of-h9c2-cells-by-activating-the-pi3k-akt-signaling-pathway-via-the-inhibition-of-ca2-influx
#8
Weihua Li, Min Lu, Yanhong Zhang, Danqin Xia, Zebin Chen, Linhua Wang, Nina Yin, Zhigang Wang
Puerarin extracted from Radix Puerariae is well known for its pharmacological effects, including antioxidant, anti‑inflammatory, neuroprotective and cardioprotective properties. In this study, we aimed to investigate the effects of puerarin on the daunorubicin (DNR)-induced apoptosis of H9c2 cells and to elucidate the potential mechanisms involved. MTT assay and flow cytometry were performed to evaluate cell cytotoxicity and apoptosis, respectively. Western blot analysis was used to assess changes in the expression levels of proteins, including caspase-3, Akt and phosphorylated Akt (p-Akt)...
October 12, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29017371/cytarabine-and-daunorubicin-for-the-treatment-of-acute-myeloid-leukemia
#9
Tracy Murphy, Karen W L Yee
Acute myeloid leukemia (AML) is the most common acute forms of leukemia in adults. It has a poor long-term survival with a high relapse rate and at relapse, is commonly resistant to available therapies. The current combination of daunorubicin (DNR) for three days and cytarabine (Ara-C) as a continuous infusion for seven days, more commonly known as '3 + 7' has remained essentially unaltered over the last forty-four years and remains the standard induction regimen internationally. Areas covered: This paper will briefly review clinically important trials related to '3 + 7'...
October 20, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28985622/outcomes-and-changes-in-code-status-of-patients-with-acute-myeloid-leukemia-undergoing-induction-chemotherapy-who-were-transferred-to-the-intensive-care-unit
#10
Tamjeed Ahmed, Abby L Koch, Scott Isom, Heidi D Klepin, Jonathan M Bishop, Leslie R Ellis, Dmitriy Berenzon, Dianna Howard, Susan Lyerly, Bayard L Powell, Timothy S Pardee
Patients with Acute Myeloid Leukemia (AML) have compromised marrow function and chemotherapy causes further suppression. As a result complications are frequent, and patients may require admission to the intensive care unit (ICU). How codes status changes when these events occur and how those changes influence outcome are largely unknown. Outcomes for adult patients with AML, undergoing induction chemotherapy, and transferred to the ICU between January 2000 and December 2013 were analyzed. 94 patients were included...
November 2017: Leukemia Research
https://www.readbyqxmd.com/read/28960720/determination-of-background-signal-to-noise-and-dynamic-range-of-a-flow-cytometer-a-novel-practical-method-for-instrument-characterization-and-standardization
#11
Claudia Giesecke, Kristen Feher, Konrad von Volkmann, Jenny Kirsch, Andreas Radbruch, Toralf Kaiser
A well-defined scale calibration in flow cytometry can improve many aspects of data acquisition such as cytometer setup, instrument comparison and sample comparison. The theory for scale calibration was proposed by Steen over two decades ago, but it has never been put into regular use due to the lack of a widely available precision light source. The introduction of such a light source, the quantiFlash(TM) , gave this possibility. Here, we describe how this light source can be used to characterize a cytometer's PMT performance...
September 27, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28958349/variation-in-do-not-resuscitate-orders-and%C3%A2-implications-for-heart-failure-risk-adjusted-hospital-mortality-metrics
#12
Jeffrey Bruckel, Anuj Mehta, Steven M Bradley, Sabu Thomas, Charles J Lowenstein, Brahmajee K Nallamothu, Allan J Walkey
OBJECTIVES: This study evaluated the effect of patient do-not-resuscitate (DNR) status on hospital risk-adjusted heart failure mortality metrics. BACKGROUND: Do-not-resuscitate orders limit the use of life-sustaining therapies. Patients with DNR orders have increased in-hospital mortality, and DNR rates vary among hospitals. Variations in DNR rates could strongly confound risk-adjusted hospital mortality rates for heart failure. METHODS: We identified a cohort of adults with primary diagnosis of heart failure by using the 2011 California State Inpatient Database, a claims database that captures "early DNR," within 24 h of admission...
October 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28941750/is-30-day-mortality-after-admission-for-heart-failure-an-appropriate-metric-for-quality
#13
Robert T Faillace, Gregory W Yost, Yashasvi Chugh, Jeffrey Adams, Beni R Verma, Zaid Said, Ibrahim Ismail Sayed, Ashley Honushefsky, Sanjay Doddamani, Peter B Berger
BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) model for publicly reporting national 30-day-risk-adjusted mortality rates for patients admitted with heart failure fails to include clinical variables known to impact total mortality or take into consideration the culture of end-of-life care. We sought to determine if those variables were related to the 30-day mortality of heart failure patients at Geisinger Medical Center. METHODS: Electronic records were searched for patients with a diagnosis of heart failure who died from any cause during hospitalization or within 30-days of admission...
September 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28935249/osteopontin-plays-a-unique-role-in-resistance-of-cd34-cd123-human-leukemia-cell-lines-kg1a-to-parthenolide
#14
Saeed Mohammadi, Mahdi Zahedpanah, Seyed Hamidollah Ghaffari, Mojgan Shaiegan, Mohsen Nikbakht, Mahin Nikugoftar
OBJECTIVES: To determine if parthenolide (PTL) is cytotoxic for leukemia-like KG1a cells and if it involves in certain molecular-mediated resistance, especially osteopontin (OPN). METHODS: PTL/daunorubicin (DNR)-treated KG1a cells were examined for viability using MTT and colony-formation assay, and stained for apoptosis using AV/PI. The gene and protein expression were evaluated by qReal-time PCR and Western blotting analysis, respectively. OPN gene was inhibited by OPN siRNA...
November 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28918550/advance-care-planning-challenges-at-the-emergency-department-of-a-cancer-care-center
#15
Maria T Cruz-Carreras, Patrick Chaftari, Jayne Viets-Upchurch
INTRODUCTION: Code status discussions form an important part of advance care planning (ACP) as it enables physicians to respect the patient's wishes for end-of-life care. However, in some cases, code status discussions can be challenging causing the physician to go against the patient's wishes and the code of medical ethics. This is especially true in an emergency setting. In this paper, we will discuss three cases of advanced cancer patients, where code status discussions posed challenges to healthcare providers...
September 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28914272/a-randomized-controlled-trial-of-a-cpr-decision-support-video-for-patients-admitted-to-the-general-medicine-service
#16
Aimee M Merino, Ryan Greiner, Kristopher Hartwig
BACKGROUND: Patient preferences regarding cardiopulmonary resuscitation (CPR) are important, especially during hospitalization when a patient's health is changing. Yet many patients are not adequately informed or involved in the decision-making process. OBJECTIVE: We examined the effect of an informational video about CPR on hospitalized patients' code status choices. DESIGN: This was a prospective, randomized trial conducted at the Minneapolis Veterans Affairs Health Care System in Minnesota...
September 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28899678/behavior-of-nitrogen-removal-in-an-aerobic-sponge-based-moving-bed-biofilm-reactor
#17
Xinbo Zhang, Zi Song, Wenshan Guo, Yanmin Lu, Li Qi, Haitao Wen, Huu Hao Ngo
This study aims to investigate the behavior of nitrogen removal in an aerobic sponge based moving bed biofilm reactor by evaluating nitrification and denitrification rates of sponge biocarriers from three aerobic moving bed biofilm reactors (MBBRs) with filling ratios of 10% (R-10), 20% (R-20) and 30% (R-30). Results showed that the highest removal efficiencies of total nitrogen in three reactors were 84.5% (R-10), 93.6% (R-20) and 95.3% (R-30). Correspondingly, simultaneous nitrification and denitrification rate (SND) was 90...
December 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28881383/processes-of-code-status-transitions-in-hospitalized-patients-with-advanced-cancer
#18
Areej El-Jawahri, Kelsey Lau-Min, Ryan D Nipp, Joseph A Greer, Lara N Traeger, Samantha M Moran, Sara M D'Arpino, Ephraim P Hochberg, Vicki A Jackson, Barbara J Cashavelly, Holly S Martinson, David P Ryan, Jennifer S Temel
BACKGROUND: Although hospitalized patients with advanced cancer have a low chance of surviving cardiopulmonary resuscitation (CPR), the processes by which they change their code status from full code to do not resuscitate (DNR) are unknown. METHODS: We conducted a mixed-methods study on a prospective cohort of hospitalized patients with advanced cancer. Two physicians used a consensus-driven medical record review to characterize processes that led to code status order transitions from full code to DNR...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28875010/anti-apoptotic-effects-of-osteopontin-via-the-up-regulation-of-akt-mtor-%C3%AE-catenin-loop-in-acute-myeloid-leukemia-cells
#19
Mahdi Zahed Panah, Mohsen Nikbakht, Seyed Mehdi Sajjadi, Shahrbano Rostami, Amir Hossein Norooznezhad, Hosein Kamranzadeh Fumani, Ardeshir Ghavamzadeh, Saeed Mohammadi
Background: The conventional chemotherapeutic regimens which applied for treatment of acute myeloid leukemia (AML) mostly target tumor bulk but not leukemic stem cells (LSCs). Aberrant expression or activation of mediators such as osteopontin (OPN) or PI3K/PTEN/Akt/mTOR pathway plays a key role in making prone to develop leukemia. Preventing or treating cancer by curcumin (CUR) has been suggested recently. CUR induces apoptosis and growth inhibition through various mechanisms in leukemic cells. In present study, we tried to measure the toxic response in vitro to CUR for evaluation ofchangesin cell viability, survival and molecular-mediated resistance in primary AML cells...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28872978/electing-full-code-in-hospice-patient-characteristics-and-live-discharge-rates
#20
Claire K Ankuda, Evan Fonger, Thomas O'Neil
BACKGROUND: It is unknown how many hospice enrollees elect to be full code and if this is associated with higher hospice live discharge rates. OBJECTIVE: To measure the rates of hospice enrollees electing full code, the characteristics predicting full code status, and the association of full code status with various hospice live discharge patterns. DESIGN: Retrospective cohort study of electronic medical record data. SETTING/SUBJECTS: A total of 25,636 decedents enrolled in two Michigan hospices between 2009 and 2014...
September 5, 2017: Journal of Palliative Medicine
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