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https://www.readbyqxmd.com/read/28528147/variability-and-reproducibility-of-segmental%C3%A2-longitudinal-strain-measurement-a-report-from-the-eacvi-ase-strain-standardization-task%C3%A2-force
#1
Oana Mirea, Efstathios D Pagourelias, Jurgen Duchenne, Jan Bogaert, James D Thomas, Luigi P Badano, Jens-Uwe Voigt
OBJECTIVES: In this study, we compared left ventricular (LV) segmental strain measurements obtained with different ultrasound machines and post-processing software packages. BACKGROUND: Global longitudinal strain (GLS) has proven to be a reproducible and valuable tool in clinical practice. Data about the reproducibility and intervendor differences of segmental strain measurements, however, are missing. METHODS: We included 63 volunteers with cardiac magnetic resonance-proven infarct scar with segmental LV function ranging from normal to severely impaired...
May 12, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28526364/surveillance-of-youth-physical-activity-and-sedentary-behavior-with-wrist-accelerometry
#2
Youngwon Kim, Paul Hibbing, Pedro F Saint-Maurice, Laura D Ellingson, Erin Hennessy, Dana L Wolff-Hughes, Frank M Perna, Gregory J Welk
INTRODUCTION: Accurate tracking of physical activity (PA) and sedentary behavior (SB) is important to advance public health, but little is known about how to interpret wrist-worn accelerometer data. This study compares youth estimates of SB and moderate to vigorous PA (MVPA) obtained using raw and count-based processing methods. METHODS: Data were collected between April and October 2014 for the National Cancer Institute's Family Life, Activity, Sun, Health, and Eating Study: a cross-sectional Internet-based study of youth/family cancer prevention behaviors...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526029/cell-fixation-and-preservation-for-droplet-based-single-cell-transcriptomics
#3
Jonathan Alles, Nikos Karaiskos, Samantha D Praktiknjo, Stefanie Grosswendt, Philipp Wahle, Pierre-Louis Ruffault, Salah Ayoub, Luisa Schreyer, Anastasiya Boltengagen, Carmen Birchmeier, Robert Zinzen, Christine Kocks, Nikolaus Rajewsky
BACKGROUND: Recent developments in droplet-based microfluidics allow the transcriptional profiling of thousands of individual cells in a quantitative, highly parallel and cost-effective way. A critical, often limiting step is the preparation of cells in an unperturbed state, not altered by stress or ageing. Other challenges are rare cells that need to be collected over several days or samples prepared at different times or locations. METHODS: Here, we used chemical fixation to address these problems...
May 19, 2017: BMC Biology
https://www.readbyqxmd.com/read/28525538/chimeraviz-a-tool-for-visualizing-chimeric-rna
#4
Stian Lågstad, Sen Zhao, Andreas M Hoff, Bjarne Johannessen, Ole Christian Lingjærde, Rolf I Skotheim
Summary: Advances in high-throughput RNA sequencing have enabled more efficient detection of fusion transcripts, but the technology and associated software used for fusion detection from sequencing data often yield a high false discovery rate. Good prioritization of the results is important, and this can be helped by a visualization framework that automatically integrates RNA data with known genomic features. Here we present chimeraviz , a Bioconductor package that automates the creation of chimeric RNA visualizations...
May 19, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28525380/comparison-among-fertility-sparing-therapies-for-well-differentiate-early-stage-endometrial-carcinoma-and-complex-atypical-hyperplasia
#5
REVIEW
Qing Zhang, Gonghua Qi, Margaux J Kanis, Ruifen Dong, Baoxia Cui, Xingsheng Yang, Beihua Kong
OBJECTIVE: To compare fertility-sparing therapies including oral progestogens, hysteroscopic resection (HR), and the levonorgestrel- releasing intrauterine system (LNG-IUS) in achieving disease regression, recurrence and live birth rate in well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia(CAH). STUDY DESIGN: This was a meta-analysis of previous studies focus on the fertility-sparing therapy for well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia (CAH)...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28521600/quantitative-structure-activity-relationship-study-of-amide-mosquito-repellents
#6
P Wang, X Xu, S Liao, J Song, G Fan, S Chen, Z Wang
A quantitative structure-activity relationship (QSAR) study on 43 amide repellents was carried out by the heuristic method in order to reveal the correlations between molecular parameters of these amides and their repellency against Aedes aegypti. Sketches and optimizations of molecular structures were achieved by the Gaussian software package. Generation and screening of molecular parameters were accomplished using CODESSA 2.7.10 software. The leave-one-out method was applied for the model validation. The results showed that a four-descriptor QSAR model with r(2) of 0...
April 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28520985/warning-statements-and-safety-practices-among-manufacturers-and-distributors-of-electronic-cigarette-liquids-in-the-united-states
#7
Pebbles Fagan, Pallav Pokhrel, Thaddeus A Herzog, Mignonne C Guy, Kari-Lyn K Sakuma, Dennis R Trinidad, Kevin Cassel, Dorothy Jorgensen, Tania Lynch, Jamie Q Felicitas-Perkins, Sherilyn Palafox, Faith Hamamura, Sarah Maloney, Kaylah Degree, Kymberle Sterling, Eric Moolchan, Mark S Clanton, Thomas Eissenberg
Introduction.: Prior to the Food and Drug Administration's (FDA) regulation of electronic cigarettes and warning statements related to nicotine addiction, there was no critical examination of manufacturer/distributor voluntary practices that could potentially inform FDA actions aimed to protect consumers. This study examined the content of warning statements and safety characteristics of electronic cigarette liquid bottles using a national sample. Methods.: Research staff randomly selected four electronic cigarette liquid manufacturers/distributors from four U...
May 18, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28520709/updated-recommendations-for-use-of-menb-fhbp-serogroup-b-meningococcal-vaccine-advisory-committee-on-immunization-practices-2016
#8
Monica E Patton, David Stephens, Kelly Moore, Jessica R MacNeil
Two serogroup B meningococcal (MenB) vaccines are currently licensed for use in persons aged 10-25 years in the United States. The two vaccines are MenB-FHbp (Trumenba, Pfizer, Inc.) (1) and MenB-4C (Bexsero, GlaxoSmithKline Biologicals, Inc.) (2). In February 2015, the Advisory Committee on Immunization Practices (ACIP) recommended use of MenB vaccines among certain groups of persons aged ≥10 years who are at increased risk for serogroup B meningococcal disease* (Category A) (3), and in June 2015, ACIP recommended that adolescents and young adults aged 16-23 years may be vaccinated with MenB vaccines to provide short-term protection against most strains of serogroup B meningococcal disease (Category B(†)) (4)...
May 19, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28517928/integrated-modeling-of-survival-data-from-multiple-stressor-ecotoxicology-experiments
#9
Abigael H Proctor, Catherine K King, Jessica R Holan, Simon J Wotherspoon
Ecotoxicological assessments often focus on the response of an organism to an individual contaminant under standardised laboratory conditions. Under more ecologically realistic conditions however, individuals are likely to be exposed to a range of environmental conditions that have the potential to act as additional stressors. Multiple stressor experiments improve our understanding of an organism's response to a toxicant under ecologically relevant conditions and provide realistic risk assessment data. To date, there is no standardized method for analysing multiple stressor data using dose-response regression...
May 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28517043/sperm-chromatin-quality-and-dna-integrity-in-partial-versus-total-globozoospermia
#10
A R Talebi, J Ghasemzadeh, M A Khalili, I Halvaei, F Fesahat
Globozoospermia is a severe form of teratozoospermia with low incidence in infertile patients, considered as one of the important causes of male infertility. The objective was to investigate the chromatin/DNA integrity as well as apoptosis in ejaculated spermatozoa of cases with partial or total globozoospermia. Fifty-seven semen samples were divided into three groups of partial globozoospermia (n = 17), total globozoospermia (n = 10) and normozoospermia (control; n = 30). Sperm chromatin condensation, DNA integrity and apoptosis were assessed using cytochemical assays...
May 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28515633/association-between-type-2-diabetes-mellitus-and-anthropometric-measurements-a-case-control-study-in-south-india
#11
REVIEW
A Awasthi, C R Rao, D S Hegde, K Rao N
INTRODUCTION: Obesity is a major risk factor for type 2 diabetes mellitus (T2DM). Clinical evidence indicates a stronger association of diabetes with central obesity than general obesity. The present study aimed to compare the association between type 2 diabetes mellitus and different anthropometric measurements and evaluate the usefulness of these measurements in clinical practice. METHODS: A case-control study was done among 102 individuals; of whom 51 cases included diagnosed T2DM (≥ 20 years age) patients attending the Medicine out-patient consultation of a tertiary care hospital and 51 controls who were screen negative for T2DM and recruited from the local community...
March 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28514695/new-product-trial-use-of-edibles-and-unexpected-highs-among-marijuana-and-hashish-users-in-colorado
#12
Jane A Allen, Kevin C Davis, Jennifer C Duke, James M Nonnemaker, Brian R Bradfield, Matthew C Farrelly
OBJECTIVE: This study examines the relationships between trial of new marijuana or hashish products and unexpected highs, and use of edible products and unexpected highs. METHODS: We conducted an online survey of 634 adult, past-year marijuana users in Colorado. We used logistic regression models to examine the relationship between new product trial or edible use and unexpected highs. RESULTS: In the first year that recreational marijuana was legal in Colorado, 71...
May 9, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28513854/verification-of-dose-profiles-generated-by-the-convolution-algorithm-of-the-gamma-knife-%C3%A2-radiosurgery-planning-system
#13
Hyun-Tai Chung, Jeong-Hoon Park, Kook Jin Chun
PURPOSE: A convolution algorithm that takes into account electron-density inhomogeneity was recently introduced to calculate dose distributions for the Gamma Knife (GK) Perfexion(™) treatment planning program. The accuracies of the dose distributions computed using the convolution method were assessed using an anthropomorphic phantom and film dosimetry. METHODS: Absorbed-dose distributions inside a phantom (CIRS Radiosurgery Head Phantom, Model 605) were calculated using the convolution method of the GK treatment-planning software (Leksell Gamma Plan(®) version 10...
May 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28513297/former-food-products-safety-microbiological-quality-and-computer-vision-evaluation-of-packaging-remnants-contamination
#14
M Tretola, A R Di Rosa, E Tirloni, M Ottoboni, C Giromini, F Leone, C E M Bernardi, V Dell'Orto, V Chiofalo, L Pinotti
The use of alternative feed ingredients in farm animal's diets can be an interesting choice from several standpoints, including safety. In this respect, the aim of this study was to investigate the safety features of selected Former Food Products (FFPs) intended for animal nutrition produced in the framework of IZS PLV 06/14 RC project by a FFP processing plant. Six FFP samples, both mash and pelleted, were analysed for the enumeration of Total Viable Count (TVC) (ISO 4833), Enterobacteriaceae (ISO 21528-1), Escherichia coli (ISO 16649-1), coagulase-positive Staphylococci (CPS) (ISO 6888), presumptive B...
May 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28512712/post-translational-tubulin-modifications-in-human-astrocyte-cultures
#15
V Bleu Knight, Elba E Serrano
The cytoskeletal protein tubulin plays an integral role in the functional specialization of many cell types. In the central nervous system, post-translational modifications and the expression of specific tubulin isotypes in neurons have been analyzed in greater detail than in their astrocytic counterparts. In this study, we characterized post-translational specifications of tubulin in human astrocytes using the normal human astrocyte (NHA; Lonza) commercial cell line of fetal origin. Immunocytochemical techniques were implemented in conjunction with confocal microscopy to image class III β-tubulin (βIII-tubulin), acetylated tubulin, and polyglutamylated tubulin using fluorescent antibody probes...
May 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28511108/wine-yeasts-identification-by-maldi-tof-ms-optimization-of-the-preanalytical-steps-and-development-of-an-extensible-open-source-platform-for-processing-and-analysis-of-an-in-house-ms-database
#16
Cristina Gutiérrez, M Ángeles Gómez-Flechoso, Ignacio Belda, Javier Ruiz, Nour Kayali, Luis Polo, Antonio Santos
Saccharomyces cerevisiae is the most important yeast species for the production of wine and other beverages. In addition, nowadays, researchers and winemakers are aware of the influence of non-Saccharomyces in wine aroma complexity. Due to the high microbial diversity associated to several agro-food processes, such as winemaking, developing fast and accurate methods for microbial identification is demanded. In this context, MALDI-TOF MS mass fingerprint provides reliable tool for fast biotyping and classification of microorganisms...
May 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28509517/impact-of-providing-free-preventive-dental-products-without-health-workers-counselling-on-infants-tooth-brushing-and-bottle-feeding-termination-practices-a-randomised-controlled-trial
#17
E Joury, M Alghadban, K Elias, R Bedi
OBJECTIVE: To investigate the impact of an integrated oral health promotion intervention, within the Syrian national immunisation programme, which provided free preventive dental health products, without health workers' counselling, on one-year-old infants' tooth-brushing and bottle-feeding termination practices. RESEARCH DESIGN: a randomised controlled parallel-group trial. SETTING: A maternal and child health centre in Sweida city, Syria...
September 2016: Community Dental Health
https://www.readbyqxmd.com/read/28509398/the-multi-component-antirestriction-system-of-phage-p1-is-linked-to-capsid-morphogenesis
#18
Denish Piya, Leonardo Vara, William K Russell, Ry Young, Jason J Gill
Bacterial Type I restriction-modification (R-M) systems present a major barrier to foreign DNA entering the bacterial cell. The temperate phage P1 packages several proteins into the virion that protect the phage DNA from host restriction. Isogenic P1 deletion mutants were used to reconstitute the previously described restriction phenotypes associated with darA and darB. While P1ΔdarA and P1ΔdarB produced the expected phenotypes, deletions of adjacent genes hdf and ddrA also produced darA-like phenotypes and deletion of ulx produced a darB-like phenotype, implicating several new proteins of previously unknown function in the P1 dar antirestriction system...
May 16, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28508326/the-association-of-low-penetrance-genetic-risk-modifiers-with-colorectal-cancer-in-lynch-syndrome-patients-a-systematic-review-and-meta-analysis
#19
REVIEW
Neil Donald, Salim Malik, Joshua L McGuire, Kevin J Monahan
Lynch syndrome (LS) is a highly penetrant inherited cancer predisposition syndrome accounting for approximately 1000 cases of colorectal cancer (CRC) in the UK annually. LS is characterised by autosomal dominant inheritance and germline mutations in DNA mismatch repair genes. The penetrance is highly variable and the reasons for this have not been fully elucidated. This study investigates whether low penetrance genetic risk factors may result in phenotype modification in LS patients. To conduct a systematic literature review and meta-analysis to assess the association between low penetrance genetic risk modifiers and CRC in LS patients...
May 15, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28507315/the-herpesvirus-nuclear-egress-complex-component-ul31-can-be-recruited-to-sites-of-dna-damage-through-poly-adp-ribose-binding
#20
Maxwell R Sherry, Thomas J M Hay, Michael A Gulak, Arash Nassiri, Renée L Finnen, Bruce W Banfield
The herpes simplex virus (HSV) UL31 gene encodes a conserved member of the herpesvirus nuclear egress complex that not only functions in the egress of DNA containing capsids from the nucleus, but is also required for optimal replication of viral DNA and its packaging into capsids. Here we report that the UL31 protein from HSV-2 can be recruited to sites of DNA damage by sequences found in its N-terminus. The N-terminus of UL31 contains sequences resembling a poly (ADP-ribose) (PAR) binding motif suggesting that PAR interactions might mediate UL31 recruitment to damaged DNA...
May 15, 2017: Scientific Reports
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