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https://www.readbyqxmd.com/read/28820889/altered-fetal-growth-placental-abnormalities-and-stillbirth
#1
Radek Bukowski, Nellie I Hansen, Halit Pinar, Marian Willinger, Uma M Reddy, Corette B Parker, Robert M Silver, Donald J Dudley, Barbara J Stoll, George R Saade, Matthew A Koch, Carol Hogue, Michael W Varner, Deborah L Conway, Donald Coustan, Robert L Goldenberg
BACKGROUND: Worldwide, stillbirth is one of the leading causes of death. Altered fetal growth and placental abnormalities are the strongest and most prevalent known risk factors for stillbirth. The aim of this study was to identify patterns of association between placental abnormalities, fetal growth, and stillbirth. METHODS AND FINDINGS: Population-based case-control study of all stillbirths and a representative sample of live births in 59 hospitals in 5 geographic areas in the U...
2017: PloS One
https://www.readbyqxmd.com/read/28820322/platelet-rich-fibrin-prf-in-regeneration-of-intrabony-defects-a-randomized-controlled-trial
#2
Gauresh Kumar Patel, Sheela Kumar Gujjari, Veerendra Kumar S C
BACKGROUND AND OBJECTIVE: Platelet-rich fibrin (PRF) is a autologous non transfusional hemo-component with a high concentration of platelets. It incorporates leukocytes, platelets and growth factors within the dense fibrin matrix and can be used as healing biomaterial. This study assessed the adjunctive use of PRF in regenerative management of intrabony defects in comparison with open flap debridement. METHODOLOGY: 26 bilateral defects (13 per group) in 13 patients were randomized as either PRF (Test group) or Open flap debridement alone (control group) sites...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28820320/autologous-platelet-rich-fibrin-in-the-treatment-of-3-wall-intrabony-defects-in-aggressive-periodontitis-a-randomized-controlled-clinical-trial
#3
Pavan Bajaj, Esha Agarwal, Nishanth S Rao, Savitha B Naik, A R Pradeep, Nitish Kalra, N Priyanka, Minal Kumari
BACKGROUND: Platelet rich fibrin (PRF), has recently found its application in osseous regeneration. The aim of present study is to explore the efficacy of PRF in treatment of intrabony defects in aggressive periodontitis. MATERIAL AND METHODS: 54 intrabony defects in 17 patients were treated either with autologous PRF with open flap debridement (OFD) or OFD alone. Clinical and radiological parameters such as probing depth (PD), clinical attachment level (CAL), intrabony defect depth and % defect change were recorded at baseline and 9 months postoperatively...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28817406/idiopathic-myointimal-hyperplasia-of-mesenteric-veins-an-uncommon-cause-of-ischemic-colitis-with-distinct-mucosal-features
#4
Rhonda K Yantiss, Isabelle Cui, Nicole C Panarelli, Jose Jessurun
Idiopathic myointimal hyperplasia of mesenteric veins causes chronic ischemic mucosal injury with segmental strictures that mimic inflammatory bowel disease and nonocclusive ischemic colitis. It is characterized by myointimal proliferative changes that narrow the lumina of veins combined with ischemic injury and ulcers. Most cases reported to date have been diagnosed following surgical resection. The aim of this study was to determine whether mucosal changes of idiopathic myointimal hyperplasia of mesenteric veins are sufficiently sensitive and specific to allow its recognition in biopsy material...
August 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28817141/effects-of-platelet-rich-fibrin-on-palatal-wound-healing-after-free-gingival-graft-harvesting-a-comparative-randomized-controlled-clinical-trial
#5
Mustafa Ozcan, Onur Ucak, Bahar Alkaya, Seray Keceli, Gulsah Seydaoglu, M Cenk Haytac
This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing after free gingival graft (FGG) harvesting. A total of 125 patients were randomized after FGG: PRF with butyl-cyanoacrylate (BC) adhesive (PRF group; n = 42), BC adhesive alone (BC group; n = 42), and sterile wet gauze compression (WG group; n = 41). Bleeding, pain, epithelialization, feeding habits, and sensation scores were recorded for different time points. Statistically significant differences were found for all parameters in favor of the PRF group (P = ...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28817134/dimensional-change-and-microstructure-of-intraoral-bone-block-grafts-covered-with-platelet-rich-fibrin-and-a-barrier-membrane-in-ridge-augmentation-a-pilot-investigation
#6
Prisana Pripatnanont, Phetsamone Thanakone, Narit Leepong
This study investigated the dimensional change and microstructure of intraoral bone block grafts covered with platelet-rich fibrin (PRF) and a barrier membrane in ridge augmentation. Seven patients were included, with 18 implant sites (10 ramus and 8 symphysis). The average final ridge width gains in the ramus from cast-based measurement (3.86 ± 0.87 mm) and cone beam computed tomography measurements (3.63 ± 1.38 mm) were not different from the symphysis (3.36 ± 2.26 mm and 3.44 ± 1.52 mm, respectively)...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28814953/in-vitro-characterization-of-jellyfish-venom-fibrin-ogen-olytic-enzymes-from-nemopilema-nomurai
#7
Seong Kyeong Bae, Hyunkyoung Lee, Yunwi Heo, Min Jung Pyo, Indu Choudhary, Chang Hoon Han, Won Duk Yoon, Changkeun Kang, Euikyung Kim
BACKGROUND: Because jellyfish are capable of provoking envenomation in humans, they are considered hazardous organisms. Although the effects of their toxins are a matter of concern, information on the venom components, biological activity and pathological mechanisms are still scarce. Therefore, the aim of the present study was to investigate a serine protease component of Nemopilema nomurai jellyfish venom (NnV) and unveil its characteristics. METHODS: To determine the relationship between fibrinolytic activity of NnV and the serine protease, fibrin zymography was performed using metalloprotease and serine protease inhibitors...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28812469/placental-pathologic-associations-with-morbidly-adherent-placenta-potential-insights-into-pathogenesis
#8
Linda M Ernst, Rebecca L Linn, Lucy Minturn, Emily S Miller
Background The pathology that underlies morbidly adherent placenta (MAP) is poorly understood. The objective of this study was to describe the placental pathology, especially implantation site pathology, associated with MAP. Methods This was a single institution, retrospective case-control study design examining placentas of patients who delivered between January 2008 and September 2013. MAP cases were defined by the need for clinical intervention at delivery beyond spontaneous placental delivery or simple manual extraction of the placenta...
September 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28811680/the-antimicrobial-peptide-human-beta-defensin-3-is-induced-by-platelet-released-growth-factors-in-primary-keratinocytes
#9
Andreas Bayer, Justus Lammel, Mersedeh Tohidnezhad, Sebastian Lippross, Peter Behrendt, Tim Klüter, Thomas Pufe, Jochen Cremer, Holger Jahr, Franziska Rademacher, Regine Gläser, Jürgen Harder
Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an antimicrobial peptide inducibly expressed in human keratinocytes especially upon wounding. The potent antimicrobial activity of hBD-3 together with its wound closure-promoting activities suggests that hBD-3 may play a crucial role in wound healing...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28810997/cutaneous-leishmaniasis-in-a-saudi-arabian-soldier-stationed-in-the-united-states
#10
Kelly Laurent, Jason Susong, Eric Fillman, Simon Ritchie
BACKGROUND: Leishmaniasis is a common parasitic disease seen in many parts of the world, especially in areas where current U.S. and international forces are deployed. Approximately 350 million people are thought to be at risk of cutaneous leishmaniasis (CL) with an annual incidence of 1.5 million cases. Over 90% of cutaneous infections with Leishmania occur in the Middle East, Brazil, and Peru. Outbreaks of CL may occur in military personnel deployed to endemic areas. Since the incubation period for symptomatic CL ranges from weeks to months, symptoms may not appear until well after returning to the United States...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28805478/production-of-platelet-rich-plasma-gel-from-elderly-patients-under-antithrombotic-drugs-perspectives-in-chronic-wounds-care
#11
M Velier, J Magalon, A Daumas, M Cassar, P Francois, A Ghazouane, C Philandrianos, B Bertrand, C Frere, D Bernot, P Villani, F Dignat George, F Sabatier
Platelet-Rich Plasma (PRP) is an autologous biological therapy obtained by centrifuging the patient's own blood to concentrate platelets. The addition of autologous thrombin and calcium chloride to PRP allows the production of a semi-solid form called PRP gel. PRP gel is increasingly used in a variety of tissue defects and predominantly in the management of non-healing chronic wounds. The topical application of PRP gel seems promising due to the capability of platelets to store and secrete growth factors (GF), fibrin and cytokines, which are essentials for wound healing...
August 14, 2017: Platelets
https://www.readbyqxmd.com/read/28804852/the-overall-hemostatic-potential-ohp-assay
#12
Jennifer Curnow
The principle of the overall hemostatic potential (OHP) assay is the generation of a fibrin time curve by optical density readings, which represent the balance between fibrin generation, triggered by thrombin or tissue factor, and fibrinolysis, triggered by tissue plasminogen activator (tPA). OHP measures the integrated effect of procoagulant, anticoagulant, and fibrinolytic factors, and OHP assay parameters provide a means of quantifying both the coagulation and fibrinolytic potential of platelet poor plasma...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28804836/assessment-of-factor-xiii
#13
László Muszbek, Éva Katona, Adrienne Kerényi
Blood coagulation factor XIII (FXIII) is essential for maintaining hemostasis. The absence of FXIII results in severe bleeding diathesis, which without prophylaxis frequently leads to fatal bleeding. As the usual hemostasis screening tests remain normal, the diagnosis of FXIII deficiency needs specific tests. Here, we describe FXIII activity determination by the ammonia release assay, which is the first-line test in the diagnostic algorithm for FXIII deficiency. The method for another activity test, the undeservedly rarely used fibrin cross-linking assay, is also presented...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28804822/determination-of-fibrinogen-and-thrombin-time-tt
#14
Anetta Undas
Fibrinogen is measured in plasma most commonly using the Clauss method, based on the comparison of thrombin clotting times of dilutions of plasma against a plasma standard. Thrombin time (TT) is a coagulation assay, which reflects the conversion of fibrinogen to fibrin after addition of thrombin reagent. Measurement of clottable fibrinogen and TT allows detecting inborn (congenital) and acquired qualitative and quantitative disorders of fibrinogen that can lead to thrombotic or bleeding events.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28802535/the-effects-of-autologous-platelet-rich-fibrin-on-flexor-tendon-healing-in-a-rabbit-model
#15
Janice C Y Liao, Min He, Aaron W T Gan, Alphonsus K S Chong
PURPOSE: Platelet-rich plasma containing large amounts of growth factors is purported to increase repaired flexor tendon strength. However, the use of bovine thrombin has the risk of antibody formation. We evaluated the effects of the newer generation autologous platelet-rich fibrin (PRF) on flexor tendon healing. METHODS: We performed surgical repair of 32 flexor tendons from the index and ring digits of the hind paws of 8 New Zealand white rabbits. In the PRF group, the PRF membrane was either wrapped around or interposed between the repair sites...
August 9, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28801266/lipogels-responsive-to-near-infrared-light-for-the-triggered-release-of-therapeutic-agents
#16
Francisco Martín-Saavedra, Eduardo Ruiz-Hernández, Clara Escudero-Duch, Martin Prieto, Manuel Arruebo, Negar Sadeghi, Roel Deckers, Gert Storm, Wim E Hennink, Jesús Santamaría, Nuria Vilaboa
Here we report a composite system based on fibrin hydrogels that incorporate in their structure near-infrared (NIR) responsive nanomaterials and thermosensitive liposomes (TSL). Polymerized fibrin networks entrap simultaneously gold-based nanoparticles (NPs) capable of transducing NIR photon energy into heat, and lysolipid-incorporated TSL (LTSL) loaded with doxorubicin hydrochloride (DOX). NIR irradiation of the resulting hydrogels (referred to as "lipogels") with 808 nm laser light increased the temperature of the illuminated areas, leading to the release of the liposomal cargo...
August 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28799873/-birdlime-technique-using-tachosil-tissue-sealing-sheet-soaked-with-fibrin-glue-for-sutureless-vessel-transposition-in-microvascular-decompression-operative-technique-and-nuances
#17
Naoki Otani, Terushige Toyooka, Kazuya Fujii, Kosuke Kumagai, Satoru Takeuchi, Arata Tomiyama, Yasuaki Nakao, Takuji Yamamoto, Kojiro Wada, Kentaro Mori
OBJECTIVE Microvascular decompression (MVD) is effective for the treatment of trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia. The transposition technique is the standard procedure to avoid adhesions and granuloma around the decompression site but is more complex and difficult to perform than the interposition technique. The authors describe a simple and safe MVD transposition procedure they call the "birdlime" technique, which uses a tissue glue-coated collagen sponge soaked with fibrin glue, and the results of this technique...
August 11, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28799246/a-first-in-human-study-of-ds-1040-an-inhibitor-of-the-activated-form-of-thrombin-activatable-fibrinolysis-inhibitor-in-healthy-subjects-comment
#18
V Gurewich, R Pannell
In the interesting study by Zhou et al [1] of a TAFI inhibitor, DS1040, the authors state (p 962, col 1, para 3) that "When plasmin cleaves fibrin … [it] exposes C-terminal lysine residues [that] can bind both plasminogen and tPA." While this is technically correct, it is functionally misleading, as is also Figure 1 showing tPA binding to lysines. The reason is that the lysine affinity of tPA is the same as that of plasminogen [2]. This article is protected by copyright. All rights reserved.
August 11, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28796849/neutrophil-extracellular-traps-and-fibrin-in-otitis-media-analysis-of-human-and-chinchilla-temporal-bones
#19
Patricia A Schachern, Geeyoun Kwon, David E Briles, Patricia Ferrieri, Steven Juhn, Sebahattin Cureoglu, Michael M Paparella, Vladimir Tsuprun
Background: Bacterial resistance in acute otitis can result in bacterial persistence and biofilm formation, triggering chronic and recurrent infections. Objective: To investigate the middle ear inflammatory response to bacterial infection in human and chinchilla temporal bones. Design, Setting, and Participants: Six chinchillas underwent intrabullar inoculations with 0.5 mL of 106 colony-forming units (CFUs) of Streptococcus pneumoniae, serotype 2...
August 10, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28795840/a-complete-histologic-approach-to-gastrointestinal-biopsy-from-hematopoietic-stem-cell-transplant-patients-with-evidence-of-transplant-associated-gastrointestinal-thrombotic-microangiopathy
#20
Mikako Warren, Sonata Jodele, Christopher Dandoy, Kasiani C Myers, Gregory Wallace, Adam Nelson, Javier El-Bietar
CONTEXT: - Transplant-associated thrombotic microangiopathy is a serious complication of hematopoietic stem cell transplant that may progress to multi-organ dysfunction. Transplant-associated thrombotic microangiopathy may involve the intestinal vasculature (intestinal transplant-associated thrombotic microangiopathy [iTMA]), causing patients to experience debilitating symptoms of ischemic colitis, including disproportionately severe abdominal pain and gastrointestinal bleeding, requiring heavy narcotic use and frequent transfusion support...
August 10, 2017: Archives of Pathology & Laboratory Medicine
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