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https://www.readbyqxmd.com/read/29453102/preparation-of-plga-rose-bengal-colloidal-particles-by-double-emulsion-and-layer-by-layer-for-breast-cancer-treatment
#1
María F Loya-Castro, Mariana Sánchez-Mejía, Dante R Sánchez-Ramírez, Rossina Domínguez-Ríos, Noé Escareño, Paola E Oceguera-Basurto, Édgar B Figueroa-Ochoa, Antonio Quintero, Alicia Del Toro-Arreola, Antonio Topete, Adrián Daneri-Navarro
The use of colloidal particles (CPs) in the transport of drugs is developing rapidly thanks to its effectiveness and biosafety, especially in the treatment of various types of cancer. In this study Rose Bengal/PLGA CPs synthesized by double emulsion (W/O/W) and by electrostatic adsorption (layer-by-layer), were characterized and evaluated as potential breast cancer treatment. CPs were evaluated in terms of size, zeta potential, drug release kinetics and cell viability inhibition efficacy with the triple negative breast cancer cell line HCC70...
February 7, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29441979/using-pva-and-tpgs-as-combined-emulsifier-in-nanoprecipitation-method-improves-characteristics-and-anticancer-activity-of-ibuprofen-loaded-plga-nanoparticles
#2
A Sahin, F Spiroux, I Guedon, F B Arslan, E T Sarcan, T Ozkan, N Colak, S Yuksel, S Ozdemir, B Ozdemir, S Akbas, G Ultav, Y Aktas, Y Capan
In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly(lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA-TPGS (d-α-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441466/hyaluronic-acid-grafted-plga-nanoparticles-for-the-sustained-delivery-of-berberine-chloride-for-an-efficient-suppression-of-ehrlich-ascites-tumors
#3
Priyanka Bhatnagar, Manisha Kumari, Richa Pahuja, A B Pant, Y Shukla, Pradeep Kumar, K C Gupta
To promote the specific targeting and elimination of CD44-positive cancer cells, berberine chloride (BRB)-encapsulated hyaluronic acid-grafted poly(lactic-co-glycolic acid) copolymer (BRB-d(HA)-g-PLGA) nanoparticles (NPs) were prepared. The targeted action of these NPs was compared to non-targeted BRB-loaded PLGA NPs and bulk BRB. The in vitro studies demonstrated faster release of BRB and increased cytotoxicity of BRB-d(HA)-g-PLGA NPs in Hela and MCF-7 cells in comparison to BRB-PLGA NPs and bulk BRB. The uptake of BRB-d(HA)-g-PLGA NPs was increased in case of MCF-7 cells as compared to HeLa cells owing to the higher expression of CD44 receptors on MCF-7 cells...
February 13, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29424479/biomimetic-peptide-display-from-a-polymeric-nanoparticle-surface-for-targeting-and-antitumor-activity-to-human-triple-negative-breast-cancer-cells
#4
Eric M Bressler, Jayoung Kim, Ron B Shmueli, Adam C Mirando, Hojjat Bazzazi, Esak Lee, Aleksander S Popel, Niranjan B Pandey, Jordan J Green
While poly(lactic-co-glycolic acid)-block-polyethylene glycol (PLGA-PEG) nanoparticles (NPs) can encapsulate drug cargos and prolong circulation times, they show non-specific accumulation in off-target tissues. Targeted delivery of drugs to tumor tissue and tumor vasculature is a promising approach for treating solid tumors while enhancing specificity and reducing systemic toxicity. AXT050, a collagen-IV derived peptide with both antitumor and antiangiogenic properties, is shown to bind to tumor-associated integrins with high affinity, which leads to targeted accumulation in tumor tissue...
February 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29393693/combined-use-of-adipose-derived-stem-cells-and-tgf-%C3%AE-3-microspheres-promotes-articular-cartilage-regeneration-in-vivo
#5
Q Sun, L Zhang, T Xu, J Ying, B Xia, H Jing, P Tong
We investigated enhancement of articular cartilage regeneration using a combination of human adipose derived stem cells (hADSCs) and TGF-β3 microspheres (MS) in vivo. Poly-lactic-co-glycolic acid (PLGA)MS were prepared using a solid/oil/water emulsion solvent evaporation-extraction method. The morphology of the MS was evaluated by scanning electron microscopy (SEM). The release characteristic of the TGF-β3 MS was evaluated. A New Zealand rabbit model for experimental osteoarthritis (OA) was established using the anterior medial meniscus excision method...
February 2, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29391794/micelle-templated-poly-lactic-co-glycolic-acid-nanoparticles-for-hydrophobic-drug-delivery
#6
Gauri M Nabar, Kalpesh D Mahajan, Mark A Calhoun, Anthony D Duong, Matthew S Souva, Jihong Xu, Catherine Czeisler, Vinay K Puduvalli, José Javier Otero, Barbara E Wyslouzil, Jessica O Winter
Purpose: Poly(lactic-co-glycolic acid) (PLGA) is widely used for drug delivery because of its biocompatibility, ability to solubilize a wide variety of drugs, and tunable degradation. However, achieving sub-100 nm nanoparticles (NPs), as might be desired for delivery via the enhanced permeability and retention effect, is extremely difficult via typical top-down emulsion approaches. Methods: Here, we present a bottom-up synthesis method yielding PLGA/block copolymer hybrids (ie, "PolyDots"), consisting of hydrophobic PLGA chains entrapped within self-assembling poly(styrene-b-ethylene oxide) (PS-b-PEO) micelles...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29379910/nanocomposite-injectable-gels-capable-of-self-replenishing-regenerative-extracellular-microenvironments-for-in-vivo-tissue-engineering
#7
Koji Nagahama, Naho Oyama, Kimika Ono, Atsushi Hotta, Keiko Kawauchi, Takahito Nishikata
Injectable hydrogels are biomaterials that have the potential to provide scaffolds to cells for in situ tissue regeneration with a minimally invasive implantation procedure. The success of in vivo tissue engineering utilizing injectable gels depends on providing cells with appropriate scaffolds that present an instructive extracellular microenvironment, which strongly influences the survival, proliferation, organization, and function of cells encapsulated within gels. One of the most important abilities of injectable gels to achieve this function is to adsorb and retain a wide variety of requisite bioactive molecules including nutrients, extracellular matrices, and growth/differentiation factors within gels...
January 30, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29314827/macrophage-specific-in-vivo-gene-editing-using-cationic-lipid-assisted-polymeric-nanoparticles
#8
Ying-Li Luo, Cong-Fei Xu, Hong-Jun Li, Zhi-Ting Cao, Jing Liu, Ji-Long Wang, Xiao-Jiao Du, Xian-Zhu Yang, Zhen Gu, Jun Wang
The CRISPR/Cas9 gene editing technology holds promise for the treatment of multiple diseases. However, the inability to perform specific gene editing in targeted tissues and cells, which may cause off-target effects, is one of the critical bottlenecks for therapeutic application of CRISPR/Cas9. Herein, macrophage-specific promoter-driven Cas9 expression plasmids (pM458 and pM330) were constructed and encapsulated in cationic lipid-assisted PEG-b-PLGA nanoparticles (CLAN). The obtained nanoparticles encapsulating the CRISPR/Cas9 plasmids were able to specifically express Cas9 in macrophages as well as their precursor monocytes both in vitro and in vivo...
January 9, 2018: ACS Nano
https://www.readbyqxmd.com/read/29301415/ph-sensitive-polymeric-nanoparticles-of-mpeg-plga-pglu-with-hybrid-core-for-simultaneous-encapsulation-of-curcumin-and-doxorubicin-to-kill-the-heterogeneous-tumour-cells-in-breast-cancer
#9
Jian-Dong Yuan, De-Li ZhuGe, Meng-Qi Tong, Meng-Ting Lin, Xia-Fang Xu, Xing Tang, Ying-Zheng Zhao, He-Lin Xu
Most breast tumours are heterogeneous and not only contain the bulk of differentiated tumour cells but also a small population of highly tumorigenic and intrinsically drug-resistant cancer stem cells (CSCs). Herein, a pH-sensitive nanoparticle with simultaneous encapsulation of curcumin and doxorubicin (CURDOX-NPs) was prepared by using monomethoxy (polyethylene glycol)-b-P (D,L-lactic-co-glycolic acid)-b-P (L-glutamic acid) polymer to simultaneously target the differentiated tumor cells and CSCs. CURDOX-NPs had a mean diameter of 107...
January 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29258613/dual-drug-loaded-nanoneedles-with-targeting-property-for-efficient-cancer-therapy
#10
Xiangrui Yang, Shichao Wu, Wanyi Xie, Anran Cheng, Lichao Yang, Zhenqing Hou, Xin Jin
BACKGROUND: Since the anticancer drugs have diverse inhibited mechanisms to the cancer cells, the use of two or more kinds of anticancer agents may achieve excellent therapeutic effects, especially to the drug-resistant tumors. RESULTS: In this study, we developed a kind of dual drug [methotrexate (MTX) and 10-hydroxycamptothecine (HCPT)] loaded nanoneedles (DDNDs) with pronounced targeting property, high drug loading and prolonged drug release. The anti-solvent precipitation of the HCPT and MTX modified PEG-b-PLGA (PEG-b-PLGA-MTX, PPMTX) leads to nucleation of nanoneedles with nanocrystalline HCPT as the core wrapped with PPMTX as steric stabilizers...
December 19, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29216514/modulation-of-in-vitro-phagocytic-uptake-and-immunogenicity-potential-of-modified-herceptin%C3%A2-conjugated-plga-peg-nanoparticles-for-drug-delivery
#11
Apurva Badkas, Evan Frank, Zilan Zhou, Mina Jafari, Harish Chandra, Vishnu Sriram, Joo-Youp Lee, Jagjit S Yadav
There is an increasing interest in engineered nanoparticle (NP) conjugates for targeted and controlled drug delivery. However, the practical applications of these NP delivery vehicles remain constrained because of their reactivity with the body's immune system defenses resulting in undesirable off-target effects. In this study, poly(D,L lactide-co-glycolide) (PLGA)-b-polyethylene glycol (PEG) NPs conjugated to different quantities of the commercial antibody Herceptin® meant to target HER2-positive breast cancer cells were studied for their immune cell uptake and immunogenic properties (using murine macrophages and human dendritic cells)...
December 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29171970/bone-regeneration-from-human-mesenchymal-stem-cells-on-porous-hydroxyapatite-plga-collagen-bioactive%C3%A2-polymer%C3%A2-scaffolds
#12
Didarul B Bhuiyan, John C Middleton, Rina Tannenbaum, Timothy M Wick
We have developed a novel multicomponent nano-hydroxyapatite-poly(D,L-lactide-co-glycolide)-collagen biomaterial (nHAP-PLGA-collagen) with mechanical properties similar to human cancellous bone. To demonstrate the bone forming capacity of nHAP-PLGA-collagen prior to in vivo experiments, nHAP-PLGA-collagen films and 3D porous scaffolds were seeded with human mesenchymal stem cells (hMSCs) to characterize cell proliferation and osteogenic differentiation. Over 21 days hMSCs seeded on 2D nHAP-PLGA-collagen films proliferate, form nodules, deposit mineral and express high alkaline phosphatase activity (ALP) indicating commitment of hMSCs towards osteogenic lineage...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29170141/rna-nanoparticle-distribution-and-clearance-in-the-eye-after-subconjunctival-injection-with-and-without-thermosensitive-hydrogels
#13
Zhanquan Shi, S Kevin Li, Ponwanit Charoenputtakun, Chia-Yang Liu, Daniel Jasinski, Peixuan Guo
Thermodynamically and chemically stable RNA nanoparticles derived from the three-way junction (3WJ) of the pRNA from bacteriophage phi29 DNA packaging motor were examined previously for ocular delivery. It was reported that, after subconjunctival injection, RNA nanoparticles with tri-way shape entered the corneal cells but not the retinal cells, whereas particle with four-way shape entered both corneal and retinal cells. The present study evaluated ocular delivery of RNA nanoparticles with various shapes and sizes, and assessed the effect of thermosensitive hydrogels (poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid); PLGA-PEG-PLGA) for increasing the retention of RNA nanoparticles in the eye...
November 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29158830/sustained-release-talazoparib-implants-for-localized-treatment-of-brca1-deficient-breast-cancer
#14
Jodi E Belz, Rajiv Kumar, Paige Baldwin, Noelle Castilla Ojo, Ana S Leal, Darlene B Royce, Di Zhang, Anne L van de Ven, Karen T Liby, Srinivas Sridhar
Talazoparib, a potent PARP inhibitor, has shown promising clinical and pre-clinical activity by inducing synthetic lethality in cancers with germline Brca1/2 mutations. Conventional oral delivery of Talazoparib is associated with significant off-target effects, therefore we sought to develop new delivery systems in the form of an implant loaded with Talazoparib for localized, slow and sustained release of the drug at the tumor site in Brca1-deficient breast cancer. Poly(lactic-co-glycolic acid) (PLGA) implants (0...
2017: Theranostics
https://www.readbyqxmd.com/read/29157965/polymer-based-nanoparticles-loaded-with-a-tlr7-ligand-to-target-the-lymph-node-for-immunostimulation
#15
Jérôme Widmer, Cédric Thauvin, Inès Mottas, Van N'guyen, Florence Delie, Eric Allémann, Carole Bourquin
Small-molecule agonists for the Toll-like receptors (TLR) 7 and 8 are effective for the immunotherapy of skin cancer when used as topical agents. Their systemic use has however been largely unsuccessful due to dose-limiting toxicity. We propose a polymer-based nanodelivery system to target resiquimod, a TLR7 ligand, to the lymph node in order to focus the immunostimulatory activity and to prevent a generalized inflammatory response. We demonstrate successful encapsulation of resiquimod in methoxypoly(ethylene glycol)-b-poly(DL-lactic acid) (mPEG-PLA) and mixed poly(DL-lactic-co-glycolic acid) (PLGA)/mPEG-PLA nanoparticles...
November 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29130392/a-novel-hybrid-multichannel-biphasic-calcium-phosphate-granule-based-composite-scaffold-for-cartilage-tissue-regeneration
#16
Albert Jung, Preeti Makkar, Jhaleh Amirian, Byong-Taek Lee
The objective of the present study was to develop a novel hybrid multichannel biphasic calcium phosphate granule (MCG)-based composite system for cartilage regeneration. First, hyaluronic acid-gelatin (HG) hydrogel was coated onto MCG matrix (MCG-HG). Poly(lactic-co-glycolic acid) (PLGA) microspheres was separately prepared and modified with polydopamine subsequent to BMP-7 loading (B). The surface-modified microspheres were finally embedded into MCG-HG scaffold to develop the novel hybrid (MCG-HG-PLGA-PD-B) composite system...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29100464/core-shell-gene-carriers-with-different-lengths-of-plga-chains-to-transfect-endothelial-cells
#17
Xinghong Duo, Qian Li, Jun Wang, Juan Lv, Xuefang Hao, Yakai Feng, Xiangkui Ren, Changcan Shi, Wencheng Zhang
In order to improve the transfection efficiency and reduce the cytotoxicity of gene carriers, many strategies have been used to develop novel gene carriers. In this study, five complex micelles (MSP(2 k), MSP(4 k), MSP(6 k), MSP(8 k), and MSP(10 k)) were prepared from methoxy-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (mPEG-b-PLGA) and sorbitol-poly(d,l-lactide-co-glycolide)-graft-PEI (sorbitol-PLGA-g-PEI, where the designed molecular weights of PLGA chains were 2 kDa, 4 kDa, 6 kDa, 8 kDa, and 10 kDa, respectively) copolymers by a self-assembly method, and the mass ratio of mPEG-b-PLGA to sorbitol-PLGA-g-PEI was 1/3...
November 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29075111/continuous-delivery-of-propranolol-from-liposomes-in-microspheres-significantly-inhibits-infantile-hemangioma-growth
#18
Xiaonan Guo, Xiaoshuang Zhu, Dakan Liu, Yubin Gong, Jing Sun, Changxian Dong
PURPOSE: To reduce the adverse effects and high frequency of administration of propranolol to treat infantile hemangioma, we first utilized propranolol-loaded liposomes-in-microsphere (PLIM) as a novel topical release system to realize sustained release of propranolol. METHODS: PLIM was developed from encapsulating propranolol-loaded liposomes (PLs) in microspheres made of poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) copolymers (PLGA-PEG-PLGA)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29056443/pre-clinical-evaluation-of-a-themosensitive-gel-containing-epothilone-b-and-mtor-hsp90-targeted-agents-in-an-ovarian-tumor-model
#19
Dae Hwan Shin, Glen S Kwon
Despite clinical remission of epithelial ovarian cancer (EOC) after surgical resection and first-line chemotherapy, about 60% of patients will re-develop peritoneal metastasis and about 50% will relapse with chemoresistant disease. Clinical studies suggest that intra-peritoneal (i.p.) chemotherapy effectively treats residual EOC after cyto-reduction by gaining direct access into the peritoneal cavity, enabling elevated drug levels versus intravenous (i.v.) injection. However, chemoresistant disease is still problematic...
October 19, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29055734/development-of-copolymeric-nanoparticles-of-hypocrellin-b-enhanced-phototoxic-effect-and-ocular-distribution
#20
Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Senthilkumar Sankareswaran, Muthuselvam Paulsamy, Madi Madiyalakan, Rajaguru Palanisamy, Ruckmani Kandasamy, Subramanian Natesan
In the present work, we have developed a photosensitizer hypocrellin B (HB) and nano silver loaded PLGA-TPGS nanoparticles with improved singlet oxygen production for enhanced photodynamic effect for the efficient treatment of age related macular degeneration. Random copolymer (PLGA-TPGS) synthesized by ring opening and bulk polymerization was characterized by IR, (1)H NMR and TGA analysis. HBS-CP-NPs prepared by nanoprecipitation techniques were spherical shaped 89.6-753.6nm size particles with negative zeta potential...
October 18, 2017: European Journal of Pharmaceutical Sciences
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