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https://www.readbyqxmd.com/read/29663651/engineered-natural-and-synthetic-polymer-surfaces-induce-nuclear-deformation-in-osteosarcoma-cells
#1
Ezgi Antmen, Menekse Ermis, Utkan Demirci, Vasif Hasirci
Cell-substrate interactions involve constant probing of microenvironment by cells. One of the responses of cells to environmental cues is to change the conformation of their cytoplasm and nucleus. We hypothesized that surface chemistry and topography could be engineered to make these differences significant enough. When designing the substrates that would accentuate these differences, we prepared surfaces carrying cell adhesive biological cues arranged in specific patterns. Collagen type I and poly(lactic acid-co-glycolic acid) (PLGA) were used to represent substrates with biological cues and those without, and these materials were decorated with four square prism micropillars with different dimensions...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29655516/plga-%C3%AE-tcp-composite-scaffold-incorporating-salvianolic-acid-b-promotes-bone-fusion-by-angiogenesis-and-osteogenesis-in-a-rat-spinal-fusion-model
#2
Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tricalcium phosphate (PLGA/β-TCP) were fabricated with low-temperature rapid prototyping technique, which incorporated SB at low (SB-L), middle (SB-M), high (SB-H) doses, and pure PLGA/β-TCP as blank control (Con)...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29652606/development-of-pei-rank-sirna-complex-loaded-plga-nanocapsules-for-the-treatment-of-osteoporosis
#3
Deniz Sezlev Bilecen, Hasan Uludag, Vasif Hasirci
Osteoporosis, which is characterized by low bone mineral density and susceptibility to fracture, is caused by increased osteoclastic activity. Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL)/RANK signaling plays an important role in osteoclast differentiation and activation. The current treatment strategies for osteoporosis do not directly address this underlying cause and generates undesired side effects. This led to emergence of controlled delivery systems to increase drug bioavailability and efficacy specifically at the bone tissue...
March 14, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29601729/poly-ethylene-oxide-monomethyl-ether-block-poly-propylene-succinate-nanoparticles-synthesis-and-characterization-enzymatic-and-cellular-degradation-micellar-solubilization-of-paclitaxel-and-in-vitro-and-in-vivo-evaluation
#4
Alessandro Jager, Eliézer Jäger, Zdenka Syrová, Tomaš Mazel, Lubomír Kováčik, Ivan Raška, Anita Höcherl, Jan Kučka, Rafal Konefal, Jana Humajova, Pavla Pouckova, Petr Stepanek, Martin Hruby
Polyester-based nanostructures are widely studied as drug delivery systems due to their biocompatibility and biodegradability. They have already reached the clinical use. In this work we describe a new and simple biodegradable and biocompatible system as alternative to the FDA-approved polyesters (PLGA, PCL and PLA) for the delivery of the anticancer drug paclitaxel (PTX) as a model drug. A hydrophobic polyester, poly(propylene succinate) (PPS) was prepared from a non-toxic alcohol (propylene glycol) and monomer from the Krebs's cycle (succinic acid) in two steps via esterification and melt polycondensation...
March 30, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29587747/memantine-loaded-plga-pegylated-nanoparticles-for-alzheimer-s-disease-in-vitro-and-in-vivo-characterization
#5
Elena Sánchez-López, Miren Ettcheto, Maria Antonia Egea, Marta Espina, Amanda Cano, Ana Cristina Calpena, Antoni Camins, Nuria Carmona, Amélia M Silva, Eliana B Souto, Maria Luisa García
BACKGROUND: Memantine, drug approved for moderate to severe Alzheimer's disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to increase drug's action on the target site as well as decrease adverse effects. For these reason, Memantine was loaded in biodegradable PLGA nanoparticles, produced by double emulsion method and surface-coated with polyethylene glycol. MEM-PEG-PLGA nanoparticles (NPs) were aimed to target the blood-brain barrier (BBB) upon oral administration for the treatment of Alzheimer's disease...
March 27, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29559330/the-synergistic-fungicidal-effect-of-low-frequency-and-low-intensity-ultrasound-with-amphotericin-b-loaded-nanoparticles-on-c-albicans-in-vitro
#6
Min Yang, Shuang Xie, Vishnu Prasad Adhikari, Yu Dong, Yonghong Du, Dairong Li
It is difficult to effectively eradicate C. albicans using traditional antifungal agents, mainly because the low permeability of the C. albicans cell wall creates strong drug resistance. The aim of this study was to investigate the synergistic fungicidal effect and the underlying mechanisms of low-frequency and low-intensity ultrasound combined with a treatment of amphotericin B-loaded nanoparticles (AmB-NPs) against C. albicans. AmB-NPs were prepared by a poly(lactic-co-glycolic acid) (PLGA) double emulsion method...
March 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29512660/adaptive-immune-cells-are-necessary-for-the-enhanced-therapeutic-effect-of-sorafenib-loaded-nanoparticles
#7
Zhi-Bin Zhao, Jie Long, Yang-Yang Zhao, Jing-Bo Yang, Wei Jiang, Qing-Zhi Liu, Kai Yan, Liang Li, Yu-Cai Wang, Zhe-Xiong Lian
Sorafenib is a kinase inhibitor approved for the treatment of primary kidney cancer, advanced primary liver cancer, and radioactive iodine resistant advanced thyroid carcinoma. However, sorafenib usually causes serious side effects, which limit its antitumor effect. Nanoparticle based drug delivery systems have been widely used to enhance the therapeutic effects and reduce the side effects of this drug by the enhanced permeability and retention (EPR) effect. Herein, to improve the therapeutic effect of sorafenib, we developed poly(ethylene glycol)-b-poly(lactic acid-co-glycolic acid) (PEG-PLGA) based nanoparticles by a dialysis method for sorafenib encapsulation...
March 7, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29504365/layering-poly-lactic-co-glycolic-acid-based-electrospun-membranes-and-co-culture-cell-sheets-for-engineering-temporomandibular-joint-disc
#8
C-H Wang, S Wang, B Zhang, X-Y Zhang, X-J Tong, H-M Peng, X-Z Han, C Liu
The temporomandibular joint disk (TMJD) lacks blood vessels and is characterized by slow self-repair. Qualitative lesions in TMJD are difficult to repair. In this study, electrospun poly (lactic-co-glycolic acid) (PLGA) scaffolds were used to reconstruct temporomandibular joint discs by tissue engineering. Rabbit temporomandibular joint disc cells (TMJDCs) and rabbit synovium-derived mesenchymal stem cells (SMSCs) were co-cultured in 1:1 ratios. Cell sheets were induced by ascorbic acid incubated with electrospun PLGA scaffolds for 14 days in the presence (10 ng/ml in culture medium) or absence of TGF-β3...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29497292/poly-lactic-co-glycolic-acid-loaded-nanoparticles-of-betulinic-acid-for-improved-treatment-of-hepatic-cancer-characterization-in-vitro-and-in-vivo-evaluations
#9
Pranesh Kumar, Ashok K Singh, Vinit Raj, Amit Rai, Amit K Keshari, Dinesh Kumar, Biswanath Maity, Anand Prakash, Sabyasachi Maiti, Sudipta Saha
Purpose: The application of betulinic acid (B), a potent antineoplastic agent, is limited due to poor bioavailability, short plasma half-life and inappropriate tissue distribution. Thus, we aimed to prepare novel 50:50 poly(lactic- co -glycolic acid) (PLGA)-loaded B nanoparticles (BNP) and to compare its anti-hepatocellular carcinoma (HCC) activity with parent B. Methods: BNP were synthesized and characterized using different methods such as scanning electron microscopy (SEM), fourier-transform infrared (FTIR) spectrometry and particle size analyses...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29473887/characterization-stability-and-biological-activity-in-vitro-of-cathelicidin-bf-30-loaded-4-arm-star-shaped-peg-plga-microspheres
#10
Yueli Bao, Shanrong Wang, Hongli Li, Yunjiao Wang, Haiyun Chen, Minglong Yuan
BF-30 is a single chain polypeptide of an N-segment with an α-helix from cathelicidin gene encoding, and it contains 30 amino acid residues, with a relative molecular mass and isoelectric point of 3637.54 and 11.79, respectively. Cathelicidin-BF-30 was entrapped in four-arm star-shaped poly(ethylene glycol-b-dl-lactic acid-co-glycolic acid) block copolymers (4-arm-PEG-PLGA) by a double-emulsion solvent-evaporation method. Three release phases of cathelicidin-BF-30loaded 4-arm-PEG-PLGA microspheres were observed, including an initial burst-release phase, followed by a lag phase with minimal drug release and finally a secondary zero-order release phase...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29470042/fabrication-of-charge-conversion-nanoparticles-for-cancer-imaging-by-flash-nanoprecipitation
#11
Meng Li, Yisheng Xu, Jinli Sun, Mingwei Wang, Dahai Yang, Xuhong Guo, Haiyun Song, Song Cao, Yunfeng Yan
Traditional charge-conversion nanoparticles (NPs) need the breakage of acid-labile groups on the surface which impedes the rapid response to the acidic microenvironment. Here, we developed novel rod-like charge-conversion NPs with amphiphilic Dex-b-PLGA, PDMAEMA-b-PCL, and an AIE-active probe through Flash Nanoprecipitation (FNP). These NPs exhibit reversible negative-to-positive charge transition at slightly acidic pH relying on the rapid protonation/deprotonation of polymers. The size and the critical charge-conversion pH can be further tuned by varying the flow rate and polymer ratio...
February 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29453102/preparation-of-plga-rose-bengal-colloidal-particles-by-double-emulsion-and-layer-by-layer-for-breast-cancer-treatment
#12
María F Loya-Castro, Mariana Sánchez-Mejía, Dante R Sánchez-Ramírez, Rossina Domínguez-Ríos, Noé Escareño, Paola E Oceguera-Basurto, Édgar B Figueroa-Ochoa, Antonio Quintero, Alicia Del Toro-Arreola, Antonio Topete, Adrián Daneri-Navarro
The use of colloidal particles (CPs) in the transport of drugs is developing rapidly thanks to its effectiveness and biosafety, especially in the treatment of various types of cancer. In this study Rose Bengal/PLGA CPs synthesized by double emulsion (W/O/W) and by electrostatic adsorption (layer-by-layer), were characterized and evaluated as potential breast cancer treatment. CPs were evaluated in terms of size, zeta potential, drug release kinetics and cell viability inhibition efficacy with the triple negative breast cancer cell line HCC70...
February 7, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29441979/using-pva-and-tpgs-as-combined-emulsifier-in-nanoprecipitation-method-improves-characteristics-and-anticancer-activity-of-ibuprofen-loaded-plga-nanoparticles
#13
A Sahin, F Spiroux, I Guedon, F B Arslan, E T Sarcan, T Ozkan, N Colak, S Yuksel, S Ozdemir, B Ozdemir, S Akbas, G Ultav, Y Aktas, Y Capan
In the preparation of nanoparticles (NPs) by the nanoprecipitation method, emulsifiers play a key role for NPs' characteristics. The present study aimed to investigate the combined emulsifier effect on ibuprofen loaded poly(lactic-co-glycolic acid) (PLGA) NPs' characteristics and anticancer activity. Ibuprofen loaded PLGA NPs were prepared by nanoprecipitation using different concentrations of PVA (poly(vinyl alcohol)) or PVA-TPGS (d-α-tocopherol polyethylene glycol 1000 succinate) combination as emulsifier...
September 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441466/hyaluronic-acid-grafted-plga-nanoparticles-for-the-sustained-delivery-of-berberine-chloride-for-an-efficient-suppression-of-ehrlich-ascites-tumors
#14
Priyanka Bhatnagar, Manisha Kumari, Richa Pahuja, A B Pant, Y Shukla, Pradeep Kumar, K C Gupta
To promote the specific targeting and elimination of CD44-positive cancer cells, berberine chloride (BRB)-encapsulated hyaluronic acid-grafted poly(lactic-co-glycolic acid) copolymer (BRB-d(HA)-g-PLGA) nanoparticles (NPs) were prepared. The targeted action of these NPs was compared to non-targeted BRB-loaded PLGA NPs and bulk BRB. The in vitro studies demonstrated faster release of BRB and increased cytotoxicity of BRB-d(HA)-g-PLGA NPs in Hela and MCF-7 cells in comparison to BRB-PLGA NPs and bulk BRB. The uptake of BRB-d(HA)-g-PLGA NPs was increased in case of MCF-7 cells as compared to HeLa cells owing to the higher expression of CD44 receptors on MCF-7 cells...
February 13, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29424479/biomimetic-peptide-display-from-a-polymeric-nanoparticle-surface-for-targeting-and-antitumor-activity-to-human-triple-negative-breast-cancer-cells
#15
Eric M Bressler, Jayoung Kim, Ron B Shmueli, Adam C Mirando, Hojjat Bazzazi, Esak Lee, Aleksander S Popel, Niranjan B Pandey, Jordan J Green
While poly(lactic-co-glycolic acid)-block-polyethylene glycol (PLGA-PEG) nanoparticles (NPs) can encapsulate drug cargos and prolong circulation times, they show non-specific accumulation in off-target tissues. Targeted delivery of drugs to tumor tissue and tumor vasculature is a promising approach for treating solid tumors while enhancing specificity and reducing systemic toxicity. AXT050, a collagen-IV derived peptide with both antitumor and antiangiogenic properties, is shown to bind to tumor-associated integrins with high affinity, which leads to targeted accumulation in tumor tissue...
February 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29393693/combined-use-of-adipose-derived-stem-cells-and-tgf-%C3%AE-3-microspheres-promotes-articular-cartilage-regeneration-in-vivo
#16
Q Sun, L Zhang, T Xu, J Ying, B Xia, H Jing, P Tong
We investigated enhancement of articular cartilage regeneration using a combination of human adipose derived stem cells (hADSCs) and TGF-β3 microspheres (MS) in vivo. Poly-lactic-co-glycolic acid (PLGA)MS were prepared using a solid/oil/water emulsion solvent evaporation-extraction method. The morphology of the MS was evaluated by scanning electron microscopy (SEM). The release characteristic of the TGF-β3 MS was evaluated. A New Zealand rabbit model for experimental osteoarthritis (OA) was established using the anterior medial meniscus excision method...
February 2, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29391794/micelle-templated-poly-lactic-co-glycolic-acid-nanoparticles-for-hydrophobic-drug-delivery
#17
Gauri M Nabar, Kalpesh D Mahajan, Mark A Calhoun, Anthony D Duong, Matthew S Souva, Jihong Xu, Catherine Czeisler, Vinay K Puduvalli, José Javier Otero, Barbara E Wyslouzil, Jessica O Winter
Purpose: Poly(lactic-co-glycolic acid) (PLGA) is widely used for drug delivery because of its biocompatibility, ability to solubilize a wide variety of drugs, and tunable degradation. However, achieving sub-100 nm nanoparticles (NPs), as might be desired for delivery via the enhanced permeability and retention effect, is extremely difficult via typical top-down emulsion approaches. Methods: Here, we present a bottom-up synthesis method yielding PLGA/block copolymer hybrids (ie, "PolyDots"), consisting of hydrophobic PLGA chains entrapped within self-assembling poly(styrene-b-ethylene oxide) (PS-b-PEO) micelles...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29379910/nanocomposite-injectable-gels-capable-of-self-replenishing-regenerative-extracellular-microenvironments-for-in-vivo-tissue-engineering
#18
Koji Nagahama, Naho Oyama, Kimika Ono, Atsushi Hotta, Keiko Kawauchi, Takahito Nishikata
Injectable hydrogels are biomaterials that have the potential to provide scaffolds to cells for in situ tissue regeneration with a minimally invasive implantation procedure. The success of in vivo tissue engineering utilizing injectable gels depends on providing cells with appropriate scaffolds that present an instructive extracellular microenvironment, which strongly influences the survival, proliferation, organization, and function of cells encapsulated within gels. One of the most important abilities of injectable gels to achieve this function is to adsorb and retain a wide variety of requisite bioactive molecules including nutrients, extracellular matrices, and growth/differentiation factors within gels...
January 30, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29314827/macrophage-specific-in-vivo-gene-editing-using-cationic-lipid-assisted-polymeric-nanoparticles
#19
Ying-Li Luo, Cong-Fei Xu, Hong-Jun Li, Zhi-Ting Cao, Jing Liu, Ji-Long Wang, Xiao-Jiao Du, Xian-Zhu Yang, Zhen Gu, Jun Wang
The CRISPR/Cas9 gene editing technology holds promise for the treatment of multiple diseases. However, the inability to perform specific gene editing in targeted tissues and cells, which may cause off-target effects, is one of the critical bottlenecks for therapeutic application of CRISPR/Cas9. Herein, macrophage-specific promoter-driven Cas9 expression plasmids (pM458 and pM330) were constructed and encapsulated in cationic lipid-assisted PEG-b-PLGA nanoparticles (CLAN). The obtained nanoparticles encapsulating the CRISPR/Cas9 plasmids were able to specifically express Cas9 in macrophages as well as their precursor monocytes both in vitro and in vivo...
February 27, 2018: ACS Nano
https://www.readbyqxmd.com/read/29301415/ph-sensitive-polymeric-nanoparticles-of-mpeg-plga-pglu-with-hybrid-core-for-simultaneous-encapsulation-of-curcumin-and-doxorubicin-to-kill-the-heterogeneous-tumour-cells-in-breast-cancer
#20
Jian-Dong Yuan, De-Li ZhuGe, Meng-Qi Tong, Meng-Ting Lin, Xia-Fang Xu, Xing Tang, Ying-Zheng Zhao, He-Lin Xu
Most breast tumours are heterogeneous and not only contain the bulk of differentiated tumour cells but also a small population of highly tumorigenic and intrinsically drug-resistant cancer stem cells (CSCs). Herein, a pH-sensitive nanoparticle with simultaneous encapsulation of curcumin and doxorubicin (CURDOX-NPs) was prepared by using monomethoxy (polyethylene glycol)-b-P (D,L-lactic-co-glycolic acid)-b-P (L-glutamic acid) polymer to simultaneously target the differentiated tumor cells and CSCs. CURDOX-NPs had a mean diameter of 107...
January 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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