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PLGA B Cell

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https://www.readbyqxmd.com/read/27910198/degradation-and-biocompatibility-of-photoembossed-plga-acrylate-blend-for-improved-cell-adhesion
#1
Nanayaa F Hughes-Brittain, Lin Qiu, Wen Wang, Ton Peijs, Cees W M Bastiaansen
We have shown previously that PMMA-acrylate photopolymers are biocomopatible and can exhibit improved cell adhesion compared to PMMA, due to an increase in negative surface charge caused by UV radiation PLGA has been used widely in soft tissue regeneration due to its high biocompatibility and cell adhesion. This polymer is also biodegradable and can be utilised in the field of vascular regeneration. In this study, PLGA is blended with a triacrylate monomer (TPETA) to create a degradable photopolymer blend. Surface relief structures are formed on this PLGA-TPETA by photoembossing...
December 2, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27861905/attenuation-of-experimental-autoimmune-neuritis-with-locally-administered-lovastatin-encapsulating-plga-nanoparticles
#2
Kelly A Langert, Bruktawit Goshu, Evan B Stubbs
Acute inflammatory demyelinating polyneuropathy (AIDP) is an aggressive antibody- and T cell-mediated variant of Guillain-Barré Syndrome (GBS), a prominent and debilitating autoimmune disorder of the peripheral nervous system. Despite advancements in clinical management, treatment of patients with AIDP/GBS and its chronic variant CIDP remains palliative and relies on the use of non-specific immune-modulating therapies. Our laboratory has previously reported that therapeutic administration of statins safely attenuates the clinical severity of experimental autoimmune neuritis (EAN), a well-characterized animal model of AIDP/GBS, by restricting the migration of autoreactive leukocytes across peripheral nerve microvascular endoneurial endothelial cells (PNMECs) that form the blood-nerve barrier...
November 8, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27774561/the-breast-cancer-stem-cell-potency-of-copper-ii-complexes-bearing-nonsteroidal-anti-inflammatory-drugs-and-their-encapsulation-using-polymeric-nanoparticles
#3
Arvin Eskandari, Janine N Boodram, Paul B Cressey, Chunxin Lu, Peter M Bruno, Michael T Hemann, Kogularamanan Suntharalingam
We report the cancer stem cell (CSC) potency of a novel series of copper(ii)-phenanthroline complexes bearing nonsteriodial anti-inflammatory drugs: naproxen, tolfenamic acid, and indomethacin (2a-3c). Two of the complexes, 2a and 3c, kill breast CSC-enriched HMLER-shEcad cells (grown in both monolayer and three-dimensional cell cultures) to a significantly better extent than salinomycin, a well-established CSC toxin. The most potent complex in the series, 3c induces its cytotoxic effect by generating intracellular reactive oxygen species (ROS) and inhibiting cyclooxgenase-2 (COX-2) activity...
October 24, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27716630/evaluation-of-3d-printed-pcl-plga-%C3%AE-tcp-versus-collagen-membranes-for-guided-bone-regeneration-in-a-beagle-implant-model
#4
J-Y Won, C-Y Park, J-H Bae, G Ahn, C Kim, D-H Lim, D-W Cho, W-S Yun, J-H Shim, J-B Huh
Here, we compared 3D-printed polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PCL/PLGA/β-TCP) membranes with the widely used collagen membranes for guided bone regeneration (GBR) in beagle implant models. For mechanical property comparison in dry and wet conditions and cytocompatibility determination, we analyzed the rate and pattern of cell proliferation of seeded fibroblasts and preosteoblasts using the cell counting kit-8 assay and scanning electron microscopy. Osteogenic differentiation was verified using alizarin red S staining...
October 7, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27712036/in-vitro-evaluation-of-poly-lactic-co-glycolic-acid-polyisoprene-fibers-for-soft-tissue-engineering
#5
Douglas R Marques, Luís A L Dos Santos, Marie A O'Brien, Sarah H Cartmell, Julie E Gough
The polymeric blend of poly (lactic-co-glycolic acid) (PLGA) and polyisoprene (PI) has recently been explored for application as stents for tracheal stenosis and spring for the treatment of craniosynostosis. From the positive results presented in other biomedical applications comes the possibility of investigating the application of this material as scaffold for tissue engineering (TE), acquiring a deeper knowledge about the polymeric blend by exploring a new processing technique while attending to the most fundamental demands of TE scaffolds...
October 6, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27684050/effect-of-feeder-free-poly-lactide-co-glycolide-scaffolds-on-morphology-proliferation-and-pluripotency-of-mouse-embryonic-stem-cells
#6
Andrea G Galuppo, Pedro C Chagastelles, Douglas Gamba, Daikelly B Iglesias, Laura E Sperling, Janine Machado, Jéssica F T C Petry, Joachim Wendorff, Cesar L Petzhold, Patricia Pranke
The aim of the study has been to evaluate the morphology, proliferation, and pluripotency maintenance of mouse embryonic stem cells (mESCs) cultivated on poly(lactic-co-glycolic acid) scaffolds. The scaffolds were hydrolyzed with NaOH (treated) and nonhydrolyzed (untreated). Morphological and mechanical characterization of the scaffolds was performed. mESC were evaluated for cell viability, cytotoxicity, expression of pluripotency markers, colony morphology, and overall distribution. The treatment generated a reduction in the hydrophobic characteristics of the scaffolds, leading to a higher wettability compared to the untreated group...
September 29, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27659862/lipid-core-peptide-poly-lactic-co-glycolic-acid-as-a-highly-potent-intranasal-vaccine-delivery-system-against-group-a-streptococcus
#7
Nirmal Marasini, Zeinab G Khalil, Ashwini Kumar Giddam, Khairunnisa Abdul Ghaffar, Waleed M Hussein, Robert J Capon, Michael R Batzloff, Michael F Good, Mariusz Skwarczynski, Istvan Toth
Rheumatic heart disease represents a leading cause of mortality caused by Group A Streptococcus (GAS) infections transmitted through the respiratory route. Although GAS infections can be treated with antibiotics these are often inadequate. An efficacious GAS vaccine holds more promise, with intranasal vaccination especially attractive, as it mimics the natural route of infections and should be able to induce mucosal IgA and systemic IgG immunity. Nanoparticles were prepared by either encapsulating or coating lipopeptide-based vaccine candidate (LCP-1) on the surface of poly(lactic-co-glycolic acid) (PLGA)...
September 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27569030/surface-functionalized-ph-responsive-poly-lactic-co-glycolic-acid-based-microparticles-for-intranasal-vaccine-delivery-effect-of-surface-modification-with-chitosan-and-mannan
#8
Ze Li, Fangfang Xiong, Jintian He, Xiaojing Dai, Gaizhen Wang
In the present study, surface-functionalized, pH-responsive poly(lactic-co-glycolic acid) (PLGA) microparticles were investigated for nasal delivery of hepatitis B surface Antigen (HBsAg). pH-responsive PLGA, chitosan modified PLGA (CS-PLGA), mannan modified PLGA (MN-PLGA), mannan and chitosan co-modified PLGA (MN-CS-PLGA) microparticles were prepared utilizing a double-emulsion method. Antigen was released rapidly from four types of microparticles at pH5.0 and pH 6.0, but slowly released at pH 7.4. Mannan and chitosan surface modification enhanced intracellular microparticle uptake by macrophages...
December 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27545397/matrix-metalloproteinase-9-mmp-9-as-an-activator-of-nanosystems-for-targeted-drug-delivery-in-pancreatic-cancer
#9
Barbara Grünwald, Jennifer Vandooren, Erica Locatelli, Pierre Fiten, Ghislain Opdenakker, Paul Proost, Achim Krüger, Jean Paul Lellouche, Liron Limor Israel, Louis Shenkman, Mauro Comes Franchini
Specific cancer cell targeting is a pre-requisite for efficient drug delivery as well as for high-resolution imaging and still represents a major technical challenge. Tumor-associated enzyme-assisted targeting is a new concept that takes advantage of the presence of a specific activity in the tumor entity. MMP-9 is a protease found to be upregulated in virtually all malignant tumors. Consequently, we hypothesized that its presence can provide a de-shielding activity for targeted delivery of drugs by nanoparticles (NPs) in pancreatic cancer...
October 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27479756/improving-the-efficacy-and-safety-of-biologic-drugs-with-tolerogenic-nanoparticles
#10
Takashi K Kishimoto, Joseph D Ferrari, Robert A LaMothe, Pallavi N Kolte, Aaron P Griset, Conlin O'Neil, Victor Chan, Erica Browning, Aditi Chalishazar, William Kuhlman, Fen-Ni Fu, Nelly Viseux, David H Altreuter, Lloyd Johnston, Roberto A Maldonado
The development of antidrug antibodies (ADAs) is a common cause for the failure of biotherapeutic treatments and adverse hypersensitivity reactions. Here we demonstrate that poly(lactic-co-glycolic acid) (PLGA) nanoparticles carrying rapamycin, but not free rapamycin, are capable of inducing durable immunological tolerance to co-administered proteins that is characterized by the induction of tolerogenic dendritic cells, an increase in regulatory T cells, a reduction in B cell activation and germinal centre formation, and the inhibition of antigen-specific hypersensitivity reactions...
October 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27460069/influence-of-structural-features-on-the-cellular-uptake-behavior-of-non-targeted-polyester-based-nanocarriers
#11
Carlos E de Castro, Jean-Jacques Bonvent, Maria C C da Silva, Fabiane L F Castro, Fernando C Giacomelli
The development of delivery systems efficiently uptaken by cells is of due importance since sites of drug action are generally localized in subcellular compartments. Herein, naked and core-shell polymeric nanoparticles (NPs) have been produced from poly(lactic-co-glycolic acid)-PLGA, poly(ethylene oxide)-b-poly(ε-caprolactone)-PEO-b-PCL, and poly(ethylene oxide)-b-poly(lactic acid)-PEO-b-PLA. The nanostructures are characterized and the cellular uptake behavior is evaluated. The data evidence that cellular uptake is enhanced as the length of the hydrophilic PEO-stabilizing shell reduces and that high negative surface charge restricts cellular uptake...
November 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27398152/reconstructing-jaw-defects-with-mscs-and-plga-encapsulated-growth-factors
#12
Boon Ching Tee, Kashappa Goud H Desai, Kelly S Kennedy, Brittany Sonnichsen, Do-Gyoon Kim, Henry W Fields, Susan R Mallery, Steven P Schwendeman, Zongyang Sun
Cell and growth factor-based tissue engineering has shown great potentials for skeletal regeneration. This study tested its feasibility in reconstructing large mandibular defects and compared the efficacy of varied construction materials and sealing methods. Bilateral mandibular critical-size (5-cm(3)) defects were created on six 4-month-old domestic pigs, and grafted with β-tricalcium phosphate (βTCP) only (Group-A), βTCP with autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) (Group-B), and βTCP with BM-MSCs and biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres containing bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) (Group-C)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27393562/aptamer-mediated-delivery-of-docetaxel-to-prostate-cancer-through-polymeric-nanoparticles-for-enhancement-of-antitumor-efficacy
#13
Zhongjian Chen, Zongguang Tai, Fenfen Gu, Chuling Hu, Quangang Zhu, Shen Gao
Treatment of aggressive prostate cancer remains a great challenge due to inadequate drug distribution into the cancerous lesions after administration. This study aimed to develop aptamer-anchored nanoparticles (apt-NPs) for systemic delivery of docetaxel (DTX) and to evaluate the tumoricidal activity against the prostate cancer in vitro and in vivo. DTX-loaded apt-NPs (DTX-apt-NPs) were prepared by a solvent diffusion technique using functional PLGA-b-PEG and sodium oleate. DTX-apt-NPs were characterized by in vitro release, antitumor activity, cellular uptake and cytotoxic mechanisms...
October 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27391551/intravitreal-injection-of-proinsulin-loaded-microspheres-delays-photoreceptor-cell-death-and-vision-loss-in-the-rd10-mouse-model-of-retinitis-pigmentosa
#14
Carolina Isiegas, Jorge A Marinich-Madzarevich, Miguel Marchena, José M Ruiz, María J Cano, Pedro de la Villa, Catalina Hernández-Sánchez, Enrique J de la Rosa, Flora de Pablo
PURPOSE: The induction of proinsulin expression by transgenesis or intramuscular gene therapy has been shown previously to retard retinal degeneration in mouse and rat models of retinitis pigmentosa (RP), a group of inherited conditions that result in visual impairment. We investigated whether intraocular treatment with biodegradable poly (lactic-co-glycolic) acid microspheres (PLGA-MS) loaded with proinsulin has cellular and functional neuroprotective effects in the retina. METHODS: Experiments were performed using the Pde6brd10 mouse model of RP...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27372155/plga-microencapsulation-protects-salmonella-typhi-outer-membrane-proteins-from-acidic-degradation-and-increases-their-mucosal-immunogenicity
#15
Juan Manuel Carreño, Christian Perez-Shibayama, Cristina Gil-Cruz, Andrea Printz, Rodolfo Pastelin, Armando Isibasi, Dominic Chariatte, Yutaka Tanoue, Constantino Lopez-Macias, Bruno Gander, Burkhard Ludewig
Salmonella (S.) enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200,000 lethal cases per year. Although enteric fever can be treated appropriately with antibiotics, an increasing number of antibiotic resistant Salmonella strains is detected. While two vaccines against typhoid fever are currently on the market, their availability in subtropical endemic areas is limited because these products need to be kept in uninterrupted cold chains...
July 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27187188/pegylated-plga-nanospheres-optimized-by-design-of-experiments-for-ocular-administration-of-dexibuprofen-in-vitro-ex-vivo-and-in-vivo-characterization
#16
E Sánchez-López, M A Egea, A Cano, M Espina, A C Calpena, M Ettcheto, A Camins, E B Souto, A M Silva, M L García
Dexibuprofen-loaded PEGylated PLGA nanospheres have been developed to improve the biopharmaceutical profile of the anti-inflammatory drug for ocular administration. Dexibuprofen is the active enantiomer of ibuprofen and therefore lower doses may be applied to achieve the same therapeutic level. According to this, two batches of nanospheres of different drug concentrations, 0.5 and 1.0mg/ml respectively, have been developed (the latter corresponding to the therapeutic ibuprofen concentration for inflammatory eye diseases)...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27120980/mechanical-properties-and-osteogenic-potential-of-hydroxyapatite-plga-collagen-biomaterial-for-bone-regeneration
#17
Didarul B Bhuiyan, John C Middleton, Rina Tannenbaum, Timothy M Wick
A bone graft is a complicated structure that provides mechanical support and biological signals that regulate bone growth, reconstruction, and repair. A single-component material is inadequate to provide a suitable combination of structural support and biological stimuli to promote bone regeneration. Multicomponent composite biomaterials lack adequate bonding among the components to prevent phase separation after implantation. We have previously developed a novel multistep polymerization and fabrication process to construct a nano-hydroxyapatite-poly(D,L-lactide-co-glycolide)-collagen biomaterial (abbreviated nHAP-PLGA-collagen) with the components covalently bonded to each other...
August 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27102372/enhanced-uptake-and-transport-of-plga-modified-nanoparticles-in-cervical-cancer
#18
Lee B Sims, Louis T Curtis, Hermann B Frieboes, Jill M Steinbach-Rankins
BACKGROUND: Uncoordinated cellular proliferation and dysregulated angiogenesis in solid tumors are coupled with inadequate tissue, blood, and lymphatic vascularization. Consequently, tumors are often characterized by hypoxic regions with limited access to vascular-borne substances. In particular, systemically administered nanoparticles (NPs) targeting tumor cells and relying on vascular access to reach tumor tissue can suffer from limited therapeutic efficacy due to inhomogeneous intra-tumor distribution and insufficient cellular internalization of NPs...
2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27093541/entrapment-of-h1n1-influenza-virus-derived-conserved-peptides-in-plga-nanoparticles-enhances-t-cell-response-and-vaccine-efficacy-in-pigs
#19
Jagadish Hiremath, Kyung-il Kang, Ming Xia, Mohamed Elaish, Basavaraj Binjawadagi, Kang Ouyang, Santosh Dhakal, Jesus Arcos, Jordi B Torrelles, X Jiang, Chang Won Lee, Gourapura J Renukaradhya
Pigs are believed to be one of the important sources of emerging human and swine influenza viruses (SwIV). Influenza virus conserved peptides have the potential to elicit cross-protective immune response, but without the help of potent adjuvant and delivery system they are poorly immunogenic. Biodegradable polylactic-co-glycolic acid (PLGA) nanoparticle (PLGA-NP) based vaccine delivery system enhances cross-presentation of antigens by the professional antigen presenting cells. In this study, Norovirus P particle containing SwIV M2e (extracellular domain of the matrix protein 2) chimera and highly conserved two each of H1N1 peptides of pandemic 2009 and classical human influenza viruses were entrapped in PLGA-NPs...
2016: PloS One
https://www.readbyqxmd.com/read/27086715/a-microscopy-method-for-scanning-transmission-electron-microscopy-imaging-of-the-antibacterial-activity-of-polymeric-nanoparticles-on-a-biofilm-with-an-ionic-liquid
#20
Chisato Takahashi, Shunsuke Muto, Hiromitsu Yamamoto
In this study, we developed a scanning transmission electron microscopy (STEM) method for imaging the antibacterial activity of organic polymeric nanoparticles (NPs) toward biofilms formed by Staphylococcus epidermidis bacterial cells, for optimizing NPs to treat biofilm infections. The combination of sample preparation method using a hydrophilic ionic liquid (IL) and STEM observation using the cooling holder eliminates the need for specialized equipment and techniques for biological sample preparation. The annular dark-field STEM results indicated that the two types of biodegradable poly-(DL-lactide-co-glycolide) (PLGA) NPs: PLGA modified with chitosan (CS), and clarithromycin (CAM)-loaded + CS-modified PLGA, prepared by emulsion solvent diffusion exhibited different antibacterial activities in nanoscale...
April 18, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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