Felipe Martelli, Annelise Quig, Sarah Mele, Jiayi Lin, Tahlia L Fulton, Mia Wansbrough, Christopher K Barlow, Ralf B Schittenhelm, Travis K Johnson, Matthew D W Piper
Drosophila melanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use of this diet is limited to adult studies due to impaired larval development and survival. Here, we provide an adjusted formula that reduces the developmental period, restores fat levels, enhances body mass, and fully rescues survivorship without compromise to adult lifespan. To demonstrate an application of this formula, we explored pre-adult diet compositions of therapeutic potential in a model of an inherited metabolic disorder affecting the metabolism of branched-chain amino acids...
March 23, 2024: Scientific Reports