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https://www.readbyqxmd.com/read/29794732/elevated-methane-levels-in-small-intestinal-bacterial-overgrowth-suggests-delayed-small-bowel-and-colonic-transit
#1
Jaspreet Suri, Rahul Kataria, Zubair Malik, Henry P Parkman, Ron Schey
Limited research exists regarding the relationship between small intestinal bacterial overgrowth (SIBO), small bowel transit (SBT), and colonic transit (CT). Furthermore, symptom analysis is limited between the subtypes of SIBO: hydrogen producing (H-SIBO) and methane producing (M-SIBO). The primary aims of this study are to: compare the SBT and CT in patients with a positive lactulose breath test (LBT) to those with a normal study; compare the SBT and CT among patients with H-SIBO or M-SIBO; compare the severity of symptoms in patients with a positive LBT to those with a normal study; compare the severity of symptoms among patients with H-SIBO or M-SIBO...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29784907/a-predictive-model-for-risk-of-early-grade-%C3%A2-3-infection-in-patients-with-multiple-myeloma-not-eligible-for-transplant-analysis-of-the-first-trial
#2
Charles Dumontet, Cyrille Hulin, Meletios A Dimopoulos, Andrew Belch, Angela Dispenzieri, Heinz Ludwig, Philippe Rodon, Jan Van Droogenbroeck, Lugui Qiu, Michele Cavo, Ann Van de Velde, Juan José Lahuerta, Olivier Allangba, Jae Hoon Lee, Eileen Boyle, Aurore Perrot, Philippe Moreau, Salomon Manier, Michel Attal, Murielle Roussel, Mohamad Mohty, Jean Yves Mary, Alexandre Civet, Bruno Costa, Antoine Tinel, Yann Gaston-Mathé, Thierry Facon
Infections are a major cause of death in patients with multiple myeloma. A post hoc analysis of the phase 3 FIRST trial was conducted to characterize treatment-emergent (TE) infections and study risk factors for TE grade ≥ 3 infection. The number of TE infections/month was highest during the first 4 months of treatment (defined as early infection). Of 1613 treated patients, 340 (21.1%) experienced TE grade ≥ 3 infections in the first 18 months and 56.2% of these patients experienced their first grade ≥ 3 infection in the first 4 months...
April 26, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29768551/risk-factors-of-helicobacter-pylori-infection-in-an-urban-community-in-northeast-brazil-and-the-relationship-between-the-infection-and-gastric-diseases
#3
Irigrácin Lima Diniz Basílio, Maria de Fátima Celino Catão, Janilson Dantas de Sousa Carvalho, Francisco Paulo Freire-Neto, Leonardo Capristano Ferreira, Selma Maria Bezerra Jerônimo
INTRODUCTION: Helicobacter pylori, a water contaminant, is the primary pathogenic agent associated with gastric diseases in humans. Exposure to H. pylori is more likely higher in developing countries. This study aimed to evaluate the risk factors associated with H. pylori infection in patients undergoing endoscopy to validate the cause of dyspeptic symptoms in an urban population in northeast Brazil and to compare the urease test and polymerase chain reaction assay results with the histopathological findings...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29722629/cognitive-function-disease-burden-and-the-structural-connectome-in-systemic-lupus-erythematosus
#4
S J Wiseman, M E Bastin, E N Amft, J F F Belch, S H Ralston, J M Wardlaw
Objective To investigate brain structural connectivity in relation to cognitive abilities and systemic damage in systemic lupus erythematosus (SLE). Methods Structural and diffusion MRI data were acquired from 47 patients with SLE. Brains were segmented into 85 cortical and subcortical regions and combined with whole brain tractography to generate structural connectomes using graph theory. Global cognitive abilities were assessed using a composite variable g, derived from the first principal component of three common clinical screening tests of neurological function...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29714681/prevalence-and-distribution-of-atherosclerosis-in-a-low-to-intermediate-risk-population-assessment-with-whole-body-mr-angiography
#5
Matthew A Lambert, Jonathan R Weir-McCall, Marco Salsano, Stephen J Gandy, Daniel Levin, Ian Cavin, Roberta Littleford, Jennifer A MacFarlane, Shona Z Matthew, Richard S Nicholas, Allan D Struthers, Frank Sullivan, Shelley A Henderson, Richard D White, Jill J F Belch, J Graeme Houston
Purpose To quantify the burden and distribution of asymptomatic atherosclerosis in a population with a low to intermediate risk of cardiovascular disease. Materials and Methods Between June 2008 and February 2013, 1528 participants with 10-year risk of cardiovascular disease less than 20% were prospectively enrolled. They underwent whole-body magnetic resonance (MR) angiography at 3.0 T by using a two-injection, four-station acquisition technique. Thirty-one arterial segments were scored according to maximum stenosis...
May 1, 2018: Radiology
https://www.readbyqxmd.com/read/29603510/esophageal-provocation-tests-are-they-useful-to-improve-diagnostic-yield-of-high-resolution-manometry
#6
REVIEW
D A Carlson, S Roman
High resolution manometry (HRM) is the gold standard to diagnose esophageal motility disorders but has some limitations. The inclusion of provocative tests might enhance the diagnostic yield of HRM. These tests are easy to perform and to add to the regular manometry protocol. Multiple rapid swallows (MRS; 5 2-mL swallows) is useful to assess the contractile reserve and deglutitive inhibition. The optimal number of MRS to perform might be 3 as suggested by Mauro et al. in this issue of Neurogastroenterology & Motility...
April 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29599487/baclofen-and-gastroesophageal-reflux-disease-seeing-the-forest-through-the-trees
#7
EDITORIAL
John O Clarke, Nielsen Q Fernandez-Becker, Kirsten A Regalia, George Triadafilopoulos
Baclofen has been shown to decrease reflux events and increase lower esophageal sphincter pressure, yet has never established a clear role in the treatment of gastroesophageal reflux disease (GERD). Lei and colleagues have shown in a recent elegant study that baclofen reduces the frequency and initiation of secondary peristalsis and heightens esophageal sensitivity to capsaicin-mediated stimulation. These findings may help explain both the benefit of baclofen in conditions such as rumination and supragastric belching, as well as the apparent lack of benefit of baclofen and other GABAB agonists in long-term treatment of GERD...
March 29, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29579192/new-prospects-for-pcsk9-inhibition
#8
Ulf Landmesser, M John Chapman, Jane K Stock, Pierre Amarenco, Jill J F Belch, Jan Borén, Michel Farnier, Brian A Ference, Stephan Gielen, Ian Graham, Diederick E Grobbee, G Kees Hovingh, Thomas F Lüscher, Massimo F Piepoli, Kausik K Ray, Erik S Stroes, Olov Wiklund, Stephan Windecker, Jose Luis Zamorano, Fausto Pinto, Lale Tokgözoglu, Jeroen J Bax, Alberico L Catapano
No abstract text is available yet for this article.
March 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29574541/speech-therapy-as-treatment-for-supragastric-belching
#9
Liesbeth Ten Cate, Thomas V K Herregods, Philippe H Dejonckere, Gerrit J M Hemmink, André J P M Smout, Albert J Bredenoord
The purpose of this study was to describe a newly developed speech therapy program as an innovating therapeutic approach and to assess the results of this intervention in patients with supragastric belching. This is a retrospective analysis of prospectively gathered data from 73 patients with supragastric belching who were treated with speech therapy between 2007 and 2017. Of these, 48 were included for evaluation of therapy. Thirty patients had supragastric belching proven by 24-h impedance measurements. Eighteen patients were diagnosed by an experienced speech language pathologist as having supragastric belching according to precise criteria...
March 24, 2018: Dysphagia
https://www.readbyqxmd.com/read/29482765/safety-and-tolerability-of-prescription-omega-3-fatty-acids-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Cheng-Ho Chang, Ping-Tao Tseng, Nai-Yu Chen, Pei-Chin Lin, Pao-Yen Lin, Jane Pei-Chen Chang, Feng-Yu Kuo, Jenshinn Lin, Ming-Chang Wu, Kuan-Pin Su
BACKGROUND: Omega-3 fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] are widely recommended for health promotion. Over the last decade, prescription omega-3 fatty acid products (RxOME3FAs) have been approved for medical indications. Nonetheless, there is no comprehensive analysis of safety and tolerability of RxOME3FAs so far. METHODS: A systematic review of randomized controlled trials (RCTs) was carried out based on searches in six electronic databases...
February 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29471155/early-results-of-magnetic-sphincter-augmentation-versus-fundoplication-for-gastroesophageal-reflux-disease-systematic-review-and-meta-analysis
#11
REVIEW
Alberto Aiolfi, Emanuele Asti, Daniele Bernardi, Gianluca Bonitta, Emanuele Rausa, Stefano Siboni, Luigi Bonavina
BACKGROUND: Laparoscopic Nissen and Toupet fundoplication (LF) are currently considered gold-standard surgical treatment for Gastroesophageal Reflux Disease (GERD). Magnetic Sphincter Augmentation (MSA) is an innovative surgical procedure that has been showed to be effective to control GERD symptoms and to reduce esophageal acid exposure. The aim of this systematic review and meta-analysis was to compare early outcomes of LF and MSA. MATERIALS AND METHODS: PubMed, MEDLINE, Embase, and Cochrane databases were consulted matching the terms "Gastroesophageal reflux or heartburn", "LINX or magnetic sphincter augmentation" and "fundoplication"...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29460918/treatment-of-supragastric-belching-with-cognitive-behavioral-therapy-improves-quality-of-life-and-reduces-acid-gastroesophageal-reflux
#12
E Glasinovic, E Wynter, J Arguero, J Ooi, K Nakagawa, E Yazaki, P Hajek, C Clin Psych, P Woodland, D Sifrim
OBJECTIVES: Excessive supragastric belching (SGB) manifests as troublesome belching, and can be associated with reflux and significant impact on quality of life (QOL). In some GERD patients, SGB-associated reflux contributes to up to 1/3 of the total esophageal acid exposure. We hypothesized that a cognitive-behavioral intervention (CBT) might reduce SGB, improve QOL, and reduce acid gastroesophageal reflux (GOR). We aimed to assess the effectiveness of CBT in patients with pathological SGB...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29433433/epicardial-adipose-tissue-is-related-to-arterial-stiffness-and-inflammation-in-patients-with-cardiovascular-disease-and-type-2-diabetes
#13
Shaween Al-Talabany, Ify Mordi, J Graeme Houston, Helen M Colhoun, Jonathan R Weir-McCall, Shona Z Matthew, Helen C Looker, Daniel Levin, Jill J F Belch, Fiona Dove, Faisel Khan, Chim C Lang
BACKGROUND: Epicardial adipose tissue (EAT) is an emerging cardio-metabolic risk factor and has been shown to correlate with adverse cardiovascular (CV) outcome; however the underlying pathophysiology of this link is not well understood. The aim of this study was to evaluate the relationship between EAT and a comprehensive panel of cardiovascular risk biomarkers and pulse wave velocity (PWV) and indexed left ventricular mass (LVMI) in a cohort of patients with cardiovascular disease (CVD) and diabetes compared to controls...
February 13, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29401142/pancreatic-malignancy-or-not-role-of-18f-fdg-pet-ct-in-solving-the-diagnostic-dilemma-and-evaluating-treatment-response
#14
Ashwin Singh Parihar, Harmandeep Singh, Rajender Kumar, Vikas Gupta, Harpreet Singh, Bhagwant Rai Mittal
Immunoglobulin G4-related disease is an autoimmune entity with multisystem involvement. F-FDG PET/CT can provide important information about disease extent and severity and also aid in treatment response evaluation. We report a case of a 57-year-old woman presenting with abdominal discomfort, belching, and loss of weight in whom F-FDG PET/CT provided valuable information in diagnosis and monitoring treatment response.
April 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29388409/-should-clinicians-care-about-health-literacy-a-stimulating-framework-for-reflection-on-the-effectiveness-of-care
#15
G Henrard, M Vanmeerbeek, J L Belche, L Buret, D Giet
«Health literacy» refers to the ability to find, understand and use health information. It is a relatively new concept, which is becoming increasingly important but remains little known by clinicians. Still, insufficient levels of health literacy in our patients are common, underestimated and negatively associated with numerous health indicators. A set of practical tools are already available to the clinician. The aim of this article is to present the concept to clinicians and emphasize how it could revitalize reflection on the effectiveness of our interventions in the field...
January 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29382349/systemic-arteriosclerosis-is-associated-with-left-ventricular-remodeling-but-not-atherosclerosis-a-tascforce-study
#16
Jonathan R Weir-McCall, Matthew Lambert, Stephen J Gandy, Jill J F Belch, Ian Cavin, Shelley A Henderson, Roberta Littleford, Jennifer A Macfarlane, Shona Z Matthew, R Stephen Nicholas, Allan D Struthers, Frank Sullivan, Richard D White, J Graeme Houston
BACKGROUND: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk. METHODS: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram...
January 30, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29354987/-clinical-trial-of-gastroesophageal-reflux-disease-with-the-disharmony-between-liver-and-stomach-syndrome-treated-with-acupuncture-regulating-qi-based-on-the-compatibility-of-the-five-meridians
#17
Shimin Pan, Jinxiang Li, Xi Zhang, Ying Li, Jie Yan, Wei Zhang, Sha Hu
OBJECTIVE: To observe the clinical effects of the acupuncture regulating qi based on the compatibility of the five meridians and common western medication for gastroesophageal reflux disease with the disharmony between liver and stomach. METHODS: Sixty patients were divided into two groups according to non-erosive reflux disease (NERD) and reflux esophagitis (RE). Those in the two groups were randomly assigned into an observation group and a control group. There were 57 cases included (28 in the observation group with 2 dropping, 29 in the control group with 1 dropping)...
December 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29347978/uninvestigated-dyspepsia-and-associated-factors-of-patients-with-gastrointestinal-disorders-in-dessie-referral-hospital-northeast-ethiopia
#18
Abdurahaman Seid, Zemenu Tamir, Wondmagegn Demsiss
BACKGROUND: Dyspepsia is a common problem in the community and clinical practice with symptom(s) considered arising from the gastroduodenal region. Dyspepsia burden and associated factors vary from country to country. The aim of this study was to determine the prevalence of uninvestigated dyspepsia (UD) using Rome III criteria, associated risk factors and self-reported dyspepsia symptoms' correlation with H. pylori infection. METHODS: A cross-sectional study was conducted among randomly selected 318 out patients with gastrointestinal complaints during the period from September 1 to December 30, 2015...
January 18, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29338540/efficacy-and-safety-of-frontline-rituximab-cyclophosphamide-doxorubicin-and-prednisone-plus-bortezomib-vr-cap-or-vincristine-r-chop-in-a-subset-of-newly-diagnosed-mantle-cell-lymphoma-patients-medically-eligible-for-transplantation-in-the-randomized-phase-3
#19
Johannes Drach, Huiqiang Huang, Olga Samoilova, Andrew Belch, Charles Farber, André Bosly, Jan Novak, Jan Zaucha, Angela Dascalescu, Udomsak Bunworasate, Zvenyslava Masliak, Kateryna Vilchevskaya, Tadeusz Robak, Lixia Pei, Brendan Rooney, Helgi van de Velde, Franco Cavalli
This post-hoc subanalysis of the LYM-3002 phase 3 study assessed the efficacy and safety of substituting vincristine in rituximab, cyclophosphamide, doxorubicin and prednisone (R-CHOP; n = 42) for bortezomib (VR-CAP; n = 38) in a subgroup of 80 mantle cell lymphoma (MCL) patients aged <60 years who did not receive stem cell transplantation (SCT) despite medical eligibility. Complete response (CR)/unconfirmed CR (CRu) rates were 67 vs. 39% (odds ratio 3.69 [95% CI(confidence interval): 1.31, 10...
April 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29299438/effect-of-apium-graveolens-and-trachyspermum-copticom-on-clinical-symptoms-of-patients-with-functional-dyspepsia
#20
Maryam Azimi, Mohammad Javad Zahedi, Mitra Mehrabani, Haleh Tajadini, Farzaneh Zolala, Mohammad Reza Baneshi, Rasool Choopani, Fariba Sharififar, Ali Asadipour, Mohammad Mahdi Hayatbakhsh, Bijan Ahmadi
Objectives: This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD). Material and Methods: In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole...
November 2017: Avicenna Journal of Phytomedicine
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