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Michael karin

Melanie Streicher, Michael Themessl-Huber, Karin Schindler, Cornel Christian Sieber, Michael Hiesmayr, Dorothee Volkert
OBJECTIVES: Malnutrition in older persons is associated with an increased risk of mortality. Useful strategies to counteract malnutrition are nutritional interventions, such as fortified diets, oral nutritional supplements (ONS), tube feeding, and parenteral nutrition. Presently, it is not known if these strategies can reduce mortality risk of nursing home (NH) residents who are malnourished or at risk of malnutrition. Thus, the aim of this study was to investigate if nutritional intake and interventions are associated with mortality in this specific population...
October 11, 2016: Journal of the American Medical Directors Association
Hendrik Hähl, Jose Nabor Vargas, Alessandra Griffo, Päivi Laaksonen, Géza Szilvay, Michael Lienemann, Karin Jacobs, Ralf Seemann, Jean-Baptiste Fleury
Pure protein bilayers and vesicles are formed using the native, fungal hydrophobin HFBI. Bilayers with hydrophobic (red) and hydrophilic (blue) core are produced and, depending on the type of core, vesicles in water, oily media, and even in air can be created using microfluidic jetting. Vesicles in water are even able to incorporate functional gramicidin A pores.
October 14, 2016: Advanced Materials
Lars Agréus, Per M Hellström, Nicholas J Talley, Bengt Wallner, Anna Forsberg, Michael Vieth, Lothar Veits, Karin Björkegren, Lars Engstrand, Anna Andreasson
BACKGROUND: In Western countries the prevalence of Helicobacter pylori (H. pylori) infection may be declining but there is a lack of recent longitudinal population studies. We evaluated the changing epidemiology over a 23-year period in Sweden. MATERIALS AND METHODS: In 1989, the validated Abdominal Symptom Questionnaire (ASQ) was mailed to a random sample of inhabitants (ages 22-80 years) in a Swedish community, and 1097 (87%) responded. H. pylori serology was analysed in a representative subsample (n = 145)...
October 2016: United European Gastroenterology Journal
Karin Schindler, Michael Themessl-Huber, Michael Hiesmayr, Sigrid Kosak, Mitja Lainscak, Alessandro Laviano, Olle Ljungqvist, Mohamed Mouhieddine, Stéphane Schneider, Marian de van der Schueren, Tatjana Schütz, Christian Schuh, Pierre Singer, Peter Bauer, Claude Pichard
BACKGROUND: Inadequate nutrition during hospitalization is strongly associated with poor patient outcome, but ensuring adequate food intake is not a priority in clinical routine worldwide. This lack of priority results in inadequate and unbalanced food intake in patients and huge amounts of wasted food. OBJECTIVES: We evaluate the main factors that are associated with reduced meal intake in hospitalized patients and the differences between geographical regions. DESIGN: We conducted a descriptive analysis of data from 9 consecutive, annual, and cross-sectional nutritionDay samples (2006-2014) in a total of 91,245 adult patients in 6668 wards in 2584 hospitals in 56 countries...
October 12, 2016: American Journal of Clinical Nutrition
Kari Bø, Raul Artal, Ruben Barakat, Wendy Brown, Michael Dooley, Kelly R Evenson, Lene A H Haakstad, Karin Larsen, Bengt Kayser, Tarja I Kinnunen, Michelle F Mottola, Ingrid Nygaard, Mireille van Poppel, Britt Stuge, Gregory A L Davies
This is Part 2 of 5 in the series of evidence statements from the IOC expert committee on exercise and pregnancy in recreational and elite athletes. Part 1 focused on the effects of training during pregnancy and on the management of common pregnancy-related symptoms experienced by athletes. In Part 2, we focus on maternal and fetal perinatal outcomes.
October 12, 2016: British Journal of Sports Medicine
Oliver Mauthner, Veerle Claes, Jeremy Walston, Sandra Engberg, Isabelle Binet, Michael Dickenmann, Déla Golshayan, Karine Hadaya, Uyen Huynh-Do, Stefano Calciolari, Sabina De Geest
AIM: To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation. BACKGROUND: For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision-making and medical management...
October 12, 2016: Journal of Advanced Nursing
Angeles Duran, Eloy D Hernandez, Miguel Reina-Campos, Elias A Castilla, Shankar Subramaniam, Sindhu Raghunandan, Lewis R Roberts, Tatiana Kisseleva, Michael Karin, Maria T Diaz-Meco, Jorge Moscat
Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSCs inhibits liver inflammation and fibrosis. We found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC-associated HSCs, negatively controls HSC activation. Total body or HSC-specific p62 ablation potentiates HSCs and enhances inflammation, fibrosis, and HCC progression. p62 directly interacts with VDR and RXR promoting their heterodimerization, which is critical for VDR:RXR target gene recruitment...
October 10, 2016: Cancer Cell
Monica Vaccari, Shari N Gordon, Slim Fourati, Luca Schifanella, Namal P M Liyanage, Mark Cameron, Brandon F Keele, Xiaoying Shen, Georgia D Tomaras, Erik Billings, Mangala Rao, Amy W Chung, Karen G Dowell, Chris Bailey-Kellogg, Eric P Brown, Margaret E Ackerman, Diego A Vargas-Inchaustegui, Stephen Whitney, Melvin N Doster, Nicolo Binello, Poonam Pegu, David C Montefiori, Kathryn Foulds, David S Quinn, Mitzi Donaldson, Frank Liang, Karin Loré, Mario Roederer, Richard A Koup, Adrian McDermott, Zhong-Min Ma, Christopher J Miller, Tran B Phan, Donald N Forthal, Matthew Blackburn, Francesca Caccuri, Massimiliano Bissa, Guido Ferrari, Vaniambadi Kalyanaraman, Maria G Ferrari, DeVon Thompson, Marjorie Robert-Guroff, Silvia Ratto-Kim, Jerome H Kim, Nelson L Michael, Sanjay Phogat, Susan W Barnett, Jim Tartaglia, David Venzon, Donald M Stablein, Galit Alter, Rafick-Pierre Sekaly, Genoveffa Franchini
No abstract text is available yet for this article.
October 6, 2016: Nature Medicine
Michael Boice, Darin Salloum, Frederic Mourcin, Viraj Sanghvi, Rada Amin, Elisa Oricchio, Man Jiang, Anja Mottok, Nicolas Denis-Lagache, Giovanni Ciriello, Wayne Tam, Julie Teruya-Feldstein, Elisa de Stanchina, Wing C Chan, Sami N Malek, Daisuke Ennishi, Renier J Brentjens, Randy D Gascoyne, Michel Cogné, Karin Tarte, Hans-Guido Wendel
The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvironment marked by exacerbated lymphoid stroma activation and increased recruitment of T follicular helper (TFH) cells. These changes result from the disruption of inhibitory cell-cell interactions between the HVEM and BTLA (B and T lymphocyte attenuator) receptors...
October 6, 2016: Cell
Vandana Shashi, Loren D M Pena, Katherine Kim, Barbara Burton, Maja Hempel, Kelly Schoch, Magdalena Walkiewicz, Heather M McLaughlin, Megan Cho, Nicholas Stong, Scott E Hickey, Christine M Shuss, Michael S Freemark, Jane S Bellet, Martha Ann Keels, Melanie J Bonner, Maysantoine El-Dairi, Megan Butler, Peter G Kranz, Constance T R M Stumpel, Sylvia Klinkenberg, Karin Oberndorff, Malik Alawi, Rene Santer, Slavé Petrovski, Outi Kuismin, Satu Korpi-Heikkilä, Olli Pietilainen, Palotie Aarno, Mitja I Kurki, Alexander Hoischen, Anna C Need, David B Goldstein, Fanny Kortüm
The ASXL genes (ASXL1, ASXL2, and ASXL3) participate in body patterning during embryogenesis and encode proteins involved in epigenetic regulation and assembly of transcription factors to specific genomic loci. Germline de novo truncating variants in ASXL1 and ASXL3 have been respectively implicated in causing Bohring-Opitz and Bainbridge-Ropers syndromes, which result in overlapping features of severe intellectual disability and dysmorphic features. ASXL2 has not yet been associated with a human Mendelian disorder...
October 6, 2016: American Journal of Human Genetics
Melanie Streicher, Michael Themessl-Huber, Karin Schindler, Cornel Christian Sieber, Michael Hiesmayr, Dorothee Volkert
BACKGROUND & AIMS: Oral nutritional supplements (ONS) can be helpful for nursing home (NH) residents to prevent or treat malnutrition. Presently little is known about the use of ONS in NHs and the factors associated with its use. Thus, the aim of this analysis was to describe the use of ONS in NHs participating in the nutritionDay project and to determine characteristics of NH residents receiving ONS. METHODS: Data from nutritionDay (nD), a cross-sectional multicenter study with standardized questionnaires on resident and NH level were analyzed...
September 17, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Linnéa Schmidt, Sathishkumar Baskaran, Patrik Johansson, Narendra Padhan, Damian Matuszewski, Lydia C Green, Ludmila Elfineh, Shimei Wee, Maria Häggblad, Ulf Martens, Bengt Westermark, Karin Forsberg-Nilsson, Lene Uhrbom, Lena Claesson-Welsh, Michael Andäng, Ida-Maria Sintorn, Bo Lundgren, Ingrid Lönnstedt, Cecilia Krona, Sven Nelander
Glioblastoma multiforme (GBM, astrocytoma grade IV) is the most common malignant primary brain tumor in adults. Addressing the shortage of effective treatment options for this cancer, we explored repurposing of existing drugs into combinations with potent activity against GBM cells. We report that the phytoalexin pterostilbene is a potentiator of two drugs with previously reported anti-GBM activity, the EGFR inhibitor gefitinib and the antidepressant sertraline. Combinations of either of these two compounds with pterostilbene suppress cell growth, viability, sphere formation and inhibit migration in tumor GBM cell (GC) cultures...
September 28, 2016: Oncotarget
Corrado Cancedda, Sheila M Davis, Kerry L Dierberg, Jonathan Lascher, J Daniel Kelly, Mohammed Bailor Barrie, Alimamy Philip Koroma, Peter George, Adikali Alpha Kamara, Ronald Marsh, Manso S Sumbuya, Cameron T Nutt, Kirstin W Scott, Edgar Thomas, Katherine Bollbach, Andrew Sesay, Ahmidu Barrie, Elizabeth Barrera, Kathryn Barron, John Welch, Nahid Bhadelia, Raphael G Frankfurter, Ophelia M Dahl, Sarthak Das, Rebecca E Rollins, Bryan Eustis, Amanda Schwartz, Piero Pertile, Ilias Pavlopoulos, Allan Mayfield, Regan H Marsh, Yusupha Dibba, Danielle Kloepper, Andrew Hall, Karin Huster, Michael Grady, Kimberly Spray, David A Walton, Fodei Daboh, Cora Nally, Sahr James, Gabriel S Warren, Joyce Chang, Michael Drasher, Gina Lamin, Sherry Bangura, Ann C Miller, Annie P Michaelis, Ryan McBain, M Jana Broadhurst, Megan Murray, Eugene T Richardson, Ted Philip, Gary L Gottlieb, Joia S Mukherjee, Paul E Farmer
An epidemic of Ebola virus disease (EVD) beginning in 2013 has claimed an estimated 11 310 lives in West Africa. As the EVD epidemic subsides, it is important for all who participated in the emergency Ebola response to reflect on strengths and weaknesses of the response. Such reflections should take into account perspectives not usually included in peer-reviewed publications and after-action reports, including those from the public sector, nongovernmental organizations (NGOs), survivors of Ebola, and Ebola-affected households and communities...
October 15, 2016: Journal of Infectious Diseases
Marie von Lilienfeld-Toal, Annemarie Berger, Maximilian Christopeit, Marcus Hentrich, Claus Peter Heussel, Jana Kalkreuth, Michael Klein, Matthias Kochanek, Olaf Penack, Elke Hauf, Christina Rieger, Gerda Silling, Maria Vehreschild, Thomas Weber, Hans-Heinrich Wolf, Nicola Lehners, Enrico Schalk, Karin Mayer
BACKGROUND: Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly. METHODS: A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus...
November 2016: European Journal of Cancer
Ling Tong, Wensheng Yu, Craig A Coburn, Lei Chen, Oleg Selyutin, Qingbei Zeng, Michael P Dwyer, Anilkumar G Nair, Bandarpalle B Shankar, Seong Heon Kim, De-Yi Yang, Stuart B Rosenblum, Rebecca T Ruck, Ian W Davies, Bin Hu, Bin Zhong, Jinglai Hao, Tao Ji, Shuai Zan, Rong Liu, Sony Agrawal, Donna Carr, Stephanie Curry, Patricia McMonagle, Karin Bystol, Frederick Lahser, Paul Ingravallo, Shiying Chen, Ernest Asante-Appiah, Joseph A Kozlowski
We describe the impact of proline modifications, in our tetracyclic-indole based series of nonstructural protein 5A (NS5A) inhibitors, to their replicon profiles. This work identified NS5A inhibitors with an improved and flattened resistance profiles.
September 2, 2016: Bioorganic & Medicinal Chemistry Letters
Nathan Mellor, Leah R Band, Aleš Pěnčík, Ondřej Novák, Afaf Rashed, Tara Holman, Michael H Wilson, Ute Voß, Anthony Bishopp, John R King, Karin Ljung, Malcolm J Bennett, Markus R Owen
The hormone auxin is a key regulator of plant growth and development, and great progress has been made understanding auxin transport and signaling. Here, we show that auxin metabolism and homeostasis are also regulated in a complex manner. The principal auxin degradation pathways in Arabidopsis include oxidation by Arabidopsis thaliana gene DIOXYGENASE FOR AUXIN OXIDATION 1/2 (AtDAO1/2) and conjugation by Gretchen Hagen3s (GH3s). Metabolic profiling of dao1-1 root tissues revealed a 50% decrease in the oxidation product 2-oxoindole-3-acetic acid (oxIAA) and increases in the conjugated forms indole-3-acetic acid aspartic acid (IAA-Asp) and indole-3-acetic acid glutamic acid (IAA-Glu) of 438- and 240-fold, respectively, whereas auxin remains close to the WT...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
Daniele Viarisio, Karin Müller-Decker, Jessica C Hassel, Jean-Claude Alvarez, Christa Flechtenmacher, Michael Pawlita, Lutz Gissmann, Massimo Tommasino
No abstract text is available yet for this article.
September 17, 2016: Journal of Investigative Dermatology
Rainer Ehling, Gabriel Bsteh, Franziska Di Pauli, Harald Hegen, Michael Auer, Karin Obermair, Michaela Wagner, Florian Deisenhammer, Markus Reindl, Thomas Berger
BACKGROUND: Paroxysmal (PS) and unusual symptoms (US) as initial manifestation of multiple sclerosis (MS) are rare and often thought to indicate "benign" MS. OBJECTIVE: To investigate prevalence and clinical disease course of patients experiencing PS or US as first clinical manifestation. METHODS: Clinical, MRI and cerebrospinal fluid data of patients presenting with PS and US were obtained retrospectively and compared to patients with classical bout onset (CS)...
September 2016: Multiple Sclerosis and related Disorders
Megan M Kaneda, Karen S Messer, Natacha Ralainirina, Hongying Li, Chris Leem, Sara Gorjestani, Gyunghwi Woo, Abraham V Nguyen, Camila C Figueiredo, Philippe Foubert, Michael C Schmid, Melissa Pink, David G Winkler, Matthew Rausch, Vito J Palombella, Jeffery Kutok, Karen McGovern, Kelly A Frazer, Xuefeng Wu, Michael Karin, Roman Sasik, Ezra E W Cohen, Judith A Varner
Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer(1,2,3,4,5). In response to pathogens or injury, inflammatory macrophages express cytokines that stimulate cytotoxic T cells, while highly abundant macrophages in neoplastic and parasitic diseases express anti-inflammatory cytokines that induce immune suppression and may promote resistance to T cell checkpoint inhibitors(1,2,3,4,5,6,7). Here we show that macrophage PI(3)Kinase γ controls a critical switch between immune stimulation and suppression during inflammation and cancer...
September 19, 2016: Nature
Holly K Tabor, Seema M Jamal, Joon-Ho Yu, Julia M Crouch, Aditi G Shankar, Karin M Dent, Nick Anderson, Damon A Miller, Brett T Futral, Michael J Bamshad
A major challenge to implementing precision medicine is the need for an efficient and cost-effective strategy for returning individual genomic test results that is easily scalable and can be incorporated into multiple models of clinical practice. My46 is a Web-based tool for managing the return of genetic results that was designed and developed to support a wide range of approaches to disclosing results, ranging from traditional face-to-face disclosure to self-guided models. My46 has five key functions: set and modify results-return preferences, return results, educate, manage the return of results, and assess the return of results...
September 15, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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