Kiramat Ali Shah, Guifeng Li, Lina Song, Binbin Gao, Linyu Huang, Dazhi Luan, Haroon Iqbal, Qingri Cao, Farid Menaa, Beom-Jin Lee, Sulaiman M Alnasser, Sultan M Alshahrani, Jinghao Cui
Rizatriptan (RZT) is an efficient anti-migraine drug which belongs to the class of selective 5 HT (1B/1D) serotonin receptor agonists. Nevertheless, RZT elicits several adverse effects and RZT nasal sprays have a limited half-life, requiring repeated doses that could cause patient noncompliance or harm to the nasopharynx and cilia. The current research aimed to develop orally disintegrating films (ODFs) of RZT employing maltodextrin (MTX) and pullulan (PUL) as film-forming polymers, as well as propylene glycol (PG) as a plasticizer...
December 1, 2022: Pharmaceutics