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Gd retention

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https://www.readbyqxmd.com/read/29626524/intratumoral-evaluation-of-3d-microvasculature-and-nanoparticle-distribution-using-a-gadolinium-dendron-modified-nano-liposomal-contrast-agent-with-magnetic-resonance-micro-imaging
#1
Nobuhiro Nitta, Yoichi Takakusagi, Daisuke Kokuryo, Sayaka Shibata, Akihiro Tomita, Tatsuya Higashi, Ichio Aoki, Masafumi Harada
The enhanced permeability and retention (EPR) effect is variable depending on nanoparticle properties and tumor/vessel conditions. Thus, intratumoral evaluations of the vasculature and nanoparticle distribution are important for predicting the therapeutic efficacy and the intractability of tumors. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle delivery imaging using magnetic resonance (MR) micro-imaging technology with a gadolinium (Gd)-dendron assembled liposomal contrast agent...
April 4, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29582508/cell-assembled-nanoclusters-of-msc-targeting-gd-dota-peptide-as-a-t-2-contrast-agent-for-mri-cell-tracking
#2
Pengli Zhang, Yanhui Zhang, Binbin Li, Hailu Zhang, Haixia Lin, Zongwu Deng, Bo Tan
A cyclic peptide CC9 that targets cell membrane of mesenchymal stem cells (MSCs) is coupled with Gd-DOTA to yield a Gd-DOTA-CC9 complex as MRI contrast agent. It is used to label human MSCs (hMSCs) via electroporation. Electroporation-labeling of hMSCs with Gd-DOTA-CC9 induces cell-assembly of Gd-DOTA-CC9 nanoclusters in the cytoplasm, significantly promotes cell-labeling efficacy and intracellular retention time of the agent. In vitro MRI of labeled hMSCs exhibits significant signal reduction under T2 -weighted MRI, which can allow long-term tracking of labeled cell transplants in in vivo migration...
March 27, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29535330/evaluating-the-potential-of-chelation-therapy-to-prevent-and-treat-gadolinium-deposition-from-mri-contrast-agents
#3
Julian A Rees, Gauthier J-P Deblonde, Dahlia D An, Camille Ansoborlo, Stacey S Gauny, Rebecca J Abergel
Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents (GBCAs) for MRI, prompting the European Medicines Agency to recommend discontinuing the use of over half of the GBCAs currently approved for clinical applications. To address this problem, we find that the orally-available metal decorporation agent 3,4,3-LI(1,2-HOPO) demonstrates superior efficacy at chelating and removing Gd from the body compared to diethylenetriaminepentaacetic acid, a ligand commonly used in the United States in the GBCA Gadopentetate (Magnevist)...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329151/gadolinium-retention-brain-t1-hyperintensity-and-endogenous-metals-a-comparative-study-of-macrocyclic-versus-linear-gadolinium-chelates-in-renally-sensitized-rats
#4
Marlène Rasschaert, Andréa Emerit, Nathalie Fretellier, Cécile Factor, Philippe Robert, Jean-Marc Idée, Claire Corot
OBJECTIVES: This preclinical study was designed to compare gadolinium (Gd) brain uptake after repeated injections of a macrocyclic Gd-based contrast agent (GBCA) (gadoterate meglumine) or 2 linear GBCAs (L-GBCAs) (gadobenate dimeglumine or gadodiamide) on a translational model of moderate renal impairment in rats. METHODS: The study was carried out in subtotally nephrectomized rats. Animals received 4 intravenous injections per week of GBCA (gadoterate meglumine, gadobenate dimeglumine, or gadodiamide) for 5 weeks, resulting in a cumulative dose of 12 mmol/kg, followed by a 1-month injection-free period...
January 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29273908/evaluating-the-solvation-properties-of-metal-containing-ionic-liquids-using-the-solvation-parameter-model
#5
He Nan, Liese Peterson, Jared L Anderson
Ionic liquids (IL) have been utilized as gas chromatography stationary phases due to their high thermal stability, negligible vapor pressure, wide liquid range, and the ability to solvate a range of analytes. In this study, the solvation properties of eight room temperature ILs containing various transition and rare earth metal centers [e.g., Mn(II), Co(II), Ni(II), Nd(III), Gd(III), and Dy(III)] are characterized using the Abraham solvation parameter model. These metal-containing ILs (MCILs) consist of the trihexyl(tetradecyl)phosphonium cation and functionalized acetylacetonate ligands chelated to various metals...
December 23, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29237148/observed-deposition-of-gadolinium-in-bone-using-a-new-noninvasive-in-vivo-biomedical-device-results-of-a-small-pilot-feasibility-study
#6
Michelle L Lord, David R Chettle, James L Gräfe, Michael D Noseworthy, Fiona E McNeill
Purpose To perform a preliminary evaluation of a noninvasive measurement system to assess gadolinium deposition in bone and to investigate the relationship between the administration of gadolinium-based contrast agents (GBCAs) and gadolinium retention in bone. Materials and Methods In vivo measurement of gadolinium retention in tibia bones was performed in 11 exposed subjects who previously received GBCAs (six exposed subjects were from a study performed 5 years previously involving injection of GBCAs in healthy volunteers; five exposed subjects had self-reported GBCA exposure), and 11 sex- and age-matched control subjects without a history of GBCA exposure...
April 2018: Radiology
https://www.readbyqxmd.com/read/29180607/small-cell-carcinomas-of-the-bladder-and-lung-are-characterized-by-a-convergent-but-distinct-pathogenesis
#7
Matthew T Chang, Alexander V Penson, Neil B Desai, Nicholas D Socci, Ronglai Shen, Venkatraman Seshan, Ritika Kundra, Adam A Abeshouse, Agnes Viale, Eugene K Cha, Xueli Hao, Victor Reuter, Charles M Rudin, Bernard H Bochner, Jonathan E Rosenberg, Dean F Bajorin, Nikolaus Schultz, Michael F Berger, Gopa Iyer, David B Solit, Hikmat A Al-Ahmadie, Barry S Taylor
Background Small cell carcinoma of the bladder (SCCB) is a rare and aggressive neuroendocrine tumor with a dismal prognosis and limited treatment options. As SCCB is histologically indistinguishable from small cell lung cancer, a shared pathogenesis and cell of origin has been proposed. The aim of this study is to determine whether SCCBs arise from a pre-existent urothelial carcinoma or share a molecular pathogenesis in common with small cell lung cancer. Results We performed an integrative analysis of 61 SCCB tumors to identify histology- and organ-specific similarities and differences...
November 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29138354/efficient-er-fusion-requires-a-dimerization-and-a-c-terminal-tail-mediated-membrane-anchoring-of-rhd3
#8
Jiaqi Sun, Huanquan Zheng
The endoplasmic reticulum (ER) is a network of tubules and sheets stretching throughout the eukaryotic cells. The formation of the ER requires homotypic membrane fusion, which is mediated by a family of Dynamin-like Atlastin GTPase proteins. The Arabidopsis ( Arabidopsis thaliana ) member ROOT HAIR DEFECTIVE3 (RHD3) has been demonstrated to mediate ER membrane fusion, but how exactly RHD3 is involved in the process is still unknown. Here we conducted systemic structure-function analyses of roles of different RHD3 domains in mediating ER fusion...
January 2018: Plant Physiology
https://www.readbyqxmd.com/read/29117483/a-manganese-based-alternative-to-gadolinium-contrast-enhanced-mr-angiography-excretion-pharmacokinetics-and-metabolism
#9
Eric M Gale, Hsiao-Ying Wey, Ian Ramsay, Yi-Fen Yen, David E Sosnovik, Peter Caravan
Purpose To compare intravascular contrast enhancement produced by the manganese-based magnetic resonance (MR) imaging contrast agent manganese-N-picolyl-N,N',N'-trans-1,2-cyclohexenediaminetriacetate (Mn-PyC3A) to gadopentetate dimeglumine (Gd-DTPA) and to evaluate the excretion, pharmacokinetics, and metabolism of Mn-PyC3A. Materials and Methods Contrast material-enhanced MR angiography was performed in baboons (Papio anubis; n = 4) by using Mn-PyC3A and Gd-DTPA. Dynamic imaging was performed for 60 minutes following Mn-PyC3A injection to monitor distribution and elimination...
November 8, 2017: Radiology
https://www.readbyqxmd.com/read/29110904/retention-of-gadolinium-compounds-used-in-magnetic-resonance-imaging-a-critical-review-and-the-recommendations-of-regulatory-agencies
#10
L Martí-Bonmatí, E Martí-Bonmatí
The Spanish Agency for Drugs and Healthcare Products (AEMPS), based on the recommendations of the European Committee for Risk Assessment in Pharmacovigilance, established on 13 March 2017 that linear gadolinium-based MR contrast media, such as MultiHance, Omniscan, Magnevist (currently not marketed) and Optimark (no longer marketed in Spain), the clinical benefits do not outweigh the potential risks derived from their use. AEMPS recommends to suspend its marketing for general use based on the retention of these compounds in the brain...
November 2017: Radiología
https://www.readbyqxmd.com/read/29101783/one-pot-preparation-of-hydrophilic-manganese-oxide-nanoparticles-as-t-1-nano-contrast-agent-for-molecular-magnetic-resonance-imaging-of-renal-carcinoma-in-vitro-and-in-vivo
#11
Jingjing Li, Chen Wu, Pingfu Hou, Min Zhang, Kai Xu
Magnetic resonance imaging (MRI) contrast agents have become a necessary part for clinical practice to improve the sensitivity for the diagnosis of small lesions and injuries. Among them, manganese oxide nanoparticle (MnO NPs)-based MRI contrast agent attracts more and more attention because of their better performance in the detection of brain disease and positive enhancement in T1 -weighted image. However, the relatively low r1 relaxivity and complex synthetic route hampered their wider applications. In this work, we proposed a one-pot approach to prepare hydrophilic MnO NPs via a polyol-like method with poly (ethylene glycol) (PEG) as both a solvent and surfactant...
April 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28990973/the-issue-of-gadolinium-retained-in-tissues-insights-on-the-role-of-metal-complex-stability-by-comparing-metal-uptake-in-murine-tissues-upon-the-concomitant-administration-of-lanthanum-and-gadolinium-diethylentriamminopentaacetate
#12
Enza Di Gregorio, Giuseppe Ferrauto, Chiara Furlan, Stefania Lanzardo, Raffaele Nuzzi, Eliana Gianolio, Silvio Aime
OBJECTIVES: The aim of the study was to explore the role of the stability of metal complexes in the processes that lead to the metal retention in the brain and other tissues of mice administered with lanthanides-based contrast agents. This issue was tackled by the simultaneous injection of gadolinium (Gd)-diethylentriamminopentaacetate (DTPA) and lanthanum-DTPA, which have the same charge and structure but differ in their thermodynamic stability by 3 orders of magnitude. MATERIALS AND METHODS: A total of 20 healthy BALB/c mice were administered by a single intravenous injection with a dose consisting of 0...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28983471/gene-duplication-analysis-reveals-no-ancient-whole-genome-duplication-but-extensive-small-scale-duplications-during-genome-evolution-and-adaptation-of-schistosoma-mansoni
#13
Shuai Wang, Xing-Quan Zhu, Xuepeng Cai
Gene duplication (GD), thought to facilitate evolutionary innovation and adaptation, has been studied in many phylogenetic lineages. However, it remains poorly investigated in trematodes, a medically important parasite group that has been evolutionarily specialized during long-term host-parasite interaction. In this study, we conducted a genome-wide study of GD modes and contributions in Schistosoma mansoni, a pathogen causing human schistosomiasis. We combined several lines of evidence provided by duplicate age distributions, genomic sequence similarity, depth-of-coverage and gene synteny to identify the dominant drivers that contribute to the origins of new genes in this parasite...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28915162/the-effect-of-perinatal-gadolinium-based-contrast-agents-on-adult-mice-behavior
#14
Miski Aghnia Khairinisa, Yusuke Takatsuru, Izuki Amano, Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima, Noriyuki Koibuchi
OBJECTIVES: The aim of this study was to examine the effects of perinatal exposure to gadolinium (Gd)-based contrast agents (GBCAs) on the behavior of adulthood offspring. MATERIALS AND METHODS: Pregnant Balb/C mice (n = 5 per group) were intravenously injected with gadoterate meglumine (Magnescope, macrocyclic GBCA), gadodiamide (Omniscan, linear GBCA), or vehicle from pregnancy day 15 to 19, corresponding to embryonic day 15 to 19 of the fetus, at 2 mmol/kg body weight per day...
February 2018: Investigative Radiology
https://www.readbyqxmd.com/read/28730643/differences-in-gadolinium-retention-after-repeated-injections-of-macrocyclic-mr-contrast-agents-to-rats
#15
Simona Bussi, Alessandra Coppo, Catherine Botteron, Valérie Fraimbault, Antonello Fanizzi, Elisa De Laurentiis, Sonia Colombo Serra, Miles A Kirchin, Fabio Tedoldi, Federico Maisano
PURPOSE: To compare the levels of gadolinium in the blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposure of rats to the macrocyclic gadolinium-based contrast agents (GBCAs) gadoterate, gadobutrol, and gadoteridol. MATERIALS AND METHODS: Fifty male Wistar Han rats were randomized to three exposure groups (n = 15 per group) and one control group (n = 5). Animals in the exposure groups received a total of 20 GBCA administrations (four administrations per week for 5 consecutive weeks) at a dose of 0...
July 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28730467/organ-retention-of-gadolinium-in-mother-and-pup-mice-effect-of-pregnancy-and-type-of-gadolinium-based-contrast-agents
#16
Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Miski Aghnia Khairinisa, Oyunbold Lamid-Ochir, Amartuvshin Tumenjargal, Noriyuki Koibuchi, Hiroshi Koyama, Yoshito Tsushima
PURPOSE: To investigate the effect of pregnancy and type of gadolinium (Gd)-based contrast agents (GBCAs) on organ retention of Gd in mother and pup mice after maternal administration. MATERIALS AND METHODS: Gd-DTPA-BMA (gadodiamide) or Gd-DOTA (gadoterate dimeglumine) was administered (2.0 mmol/kg of maternal weight) four times to pregnant Balb/c mice from gestational day 16-19, respectively. At 28 days after birth, they were euthanized and their organs (blood, brain, liver, kidney, spleen, and bone) were removed for the measurement of Gd by inductively coupled plasma mass spectrometry...
October 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28728376/effect-of-condensed-tannins-from-ficus-infectoria-and-psidium-guajava-leaf-meal-mixture-on-nutrient-metabolism-methane-emission-and-performance-of-lambs
#17
A K Pathak, Narayan Dutta, A K Pattanaik, V B Chaturvedi, K Sharma
OBJECTIVE: The study examined the effect of condensed tannins (CT) containing Ficus infectoria and Psidium guajava leaf meal mixture (LMM) supplementation on nutrient metabolism, methane emission and performance of lambs. METHODS: Twenty four lambs of ~6 months age (average body weight 10.1±0.60 kg) were randomly divided into 4 dietary treatments (CT-0, CT-1, CT-1.5, and CT-2 containing 0, 1.0, 1.5, and 2.0 percent CT through LMM, respectively) consisting of 6 lambs each in a completely randomized design...
December 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28627037/quantitative-gd-dota-uptake-from-cerebrospinal-fluid-into-rat-brain-using-3d-vfa-spgr-at-9-4t
#18
Hedok Lee, Kristian Mortensen, Simon Sanggaard, Palle Koch, Hans Brunner, Bjørn Quistorff, Maiken Nedergaard, Helene Benveniste
PURPOSE: We propose a quantitative technique to assess solute uptake into the brain parenchyma based on dynamic contrast-enhanced MRI (DCE-MRI). With this approach, a small molecular weight paramagnetic contrast agent (Gd-DOTA) is infused in the cerebral spinal fluid (CSF) and whole brain gadolinium concentration maps are derived. METHODS: We implemented a 3D variable flip angle spoiled gradient echo (VFA-SPGR) longitudinal relaxation time (T1) technique, the accuracy of which was cross-validated by way of inversion recovery rapid acquisition with relaxation enhancement (IR-RARE) using phantoms...
March 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28620142/magnetic-resonance-imaging-of-rrx-001-pharmacodynamics-in-preclinical-tumors
#19
Natarajan Raghunand, Jan Scicinski, Gerald P Guntle, Bhumasamudram Jagadish, Eugene A Mash, Elizabeth Bruckheimer, Bryan Oronsky, Ronald L Korn
RRx-001 is an anticancer agent that subjects cancer cells to reactive oxygen/nitrogen species (ROS/RNS) and acts as an epigenetic modifier. We have used a thiol-bearing MRI contrast agent, Gd-LC7-SH, to investigate the pharmacodynamics of RRx-001 in CHP-100 Ewing's Sarcoma, HT-29 colorectal carcinoma, and PANC-1 pancreatic carcinoma xenografts in SCID mice. Binding of Gd-LC7-SH to the Cys34 residue on plasma albumin prolongs retention in the tumor microenvironment and increases tumor enhancement on MRI. Mice were imaged by MRI and in vivo T1 maps acquired 50 min (T150 min) after injection of 0...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28501081/the-impact-of-excess-ligand-on-the-retention-of-nonionic-linear-gadolinium-based-contrast-agents-in-patients-with-various-levels-of-renal-dysfunction-a-review-and-simulation-analysis
#20
REVIEW
John P Prybylski, Michael Jay
The role of gadolinium (Gd)-based contrast agents (GBCAs) in the pathophysiology of nephrogenic systemic fibrosis (NSF) is now uncontested. Although the definitive mechanism has not been established, the association with weaker GBCA ligands and with reduced renal clearance supports a hypothesis that Gd release from the GBCAs is a key process in precipitating the disease. Prevention strategies often include the use of more stable GBCA ligands in patients with reduced kidney function, but animal models and some clinical data suggest that better patient outcomes can be achieved when excess ligand is administered with weaker GBCAs; this is particularly significant for OptiMARK, which contains a nonionic, linear ligand similar to gadodiamide, the active ingredient in Omniscan, but contains twice the amount of excess ligand...
May 2017: Advances in Chronic Kidney Disease
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