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Gadolinium retention

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https://www.readbyqxmd.com/read/28076722/is-there-long-term-signal-intensity-increase-in-the-central-nervous-system-on-t1-weighted-images-after-mr-imaging-with-the-hepatospecific-contrast-agent-gadoxetic-acid-a-cross-sectional-study-in-91-patients
#1
Johannes Kahn, Helena Posch, Ingo G Steffen, Dominik Geisel, Christian Bauknecht, Thomas Liebig, Timm Denecke
Purpose To evaluate whether there is T1-weighted signal intensity (SI) increase in the dentate nucleus (DN) and globus pallidus (GP) in relation to the middle cerebellar peduncle (MCP), pons, and thalamus after repeated administration of the liver-specific contrast agent gadoxetic acid. Materials and Methods This was an institutional review board-approved, prospectively conducted (written informed consent acquired), cross-sectional study performed in a consecutively selected patient group (n = 91; patients received one to 37 doses of gadoxetic acid) and a control group (n = 52; subjects had never received injections of gadolinium-based contrast agent) examined with a standard T1-weighted two-dimensional spin-echo pulse sequence of the brain at 1...
January 11, 2017: Radiology
https://www.readbyqxmd.com/read/28060285/preparation-and-in-vitro-characterization-of-dendrimer-based-contrast-agents-for-magnetic-resonance-imaging
#2
Serhat Gündüz, Tanja Savić, Đorđe Toljić, Goran Angelovski
Paramagnetic complexes of gadolinium(III) with acyclic or macrocyclic chelates are the most commonly used contrast agents (CAs) for magnetic resonance imaging (MRI). Their purpose is to enhance the relaxation rate of water protons in tissue, thus increasing the MR image contrast and the specificity of the MRI measurements. Current clinically approved contrast agents are low molecular weight molecules that are rapidly cleared from the body. The use of dendrimers as carriers of paramagnetic chelators can play an important role in the future development of more efficient MRI contrast agents...
December 4, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28005498/gadolinium-retention-in-the-body-and-brain-is-it-time-for-an-international-joint-research-effort
#3
Carlo Cosimo Quattrocchi, Aart J van der Molen
No abstract text is available yet for this article.
January 2017: Radiology
https://www.readbyqxmd.com/read/27987464/confirming-improved-detection-of-gadolinium-in-bone-using-in-vivo-xrf
#4
M L Lord, F E McNeill, J L Gräfe, A L Galusha, P J Parsons, M D Noseworthy, L Howard, D R Chettle
The safety of using Gd in MRI contrast agents has recently been questioned, due to recent evidence of the retention of Gd in individuals with healthy renal function. Bone has proven to be a storage site for Gd, as unusually high concentrations have been measured in femoral heads of patients undergoing hip replacement surgery, as well as in autopsy samples. All previous measurements of Gd in bone have been invasive and required the bone to be removed from the body. X-ray fluorescence (XRF) offers a non-invasive and non-destructive method for carrying out in vivo measurements of Gd in humans...
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27885402/-retention-of-contrast-media-in-the-history-of-radiology-sequelae%C3%A2-of%C3%A2-the-former-use-of-thorotrast-and-new-challenges
#5
G van Kaick, S Delorme
Detection of gadolinium deposits in patients who have repeatedly been administered intravenous gadolinium chelates have given rise to concern regarding the long-term safety of magnetic resonance imaging (MRI) contrast media. Nevertheless, negative long-term clinical effects have not yet been observed. In some publications parallels have been drawn to the sequelae of thorotrast that was formerly used for arterial angiography. In this article the history of thorotrast use is briefly described and in particular why, despite warnings, this substance was used frequently and worldwide...
December 2016: Der Radiologe
https://www.readbyqxmd.com/read/27837539/gadolinium-loaded-polychelating-polymer-containing-tumor-targeted-liposomes
#6
Suna Erdogan, Vladimir P Torchilin
Magnetic resonance (MR) is one of the most widely used imaging modalities in contemporary medicine to obtain images of pathological areas. Still, there is a big effort to facilitate the accumulation of contrast in the required zone and further increase a local spatial concentration of a contrast agent for better imaging. Certain particulate carriers able to carry multiple contrast moieties can be used for an efficient delivery of contrast agents to areas of interest and enhancing a signal from these areas. Among those carriers, liposomes draw special attention because of their easily controlled properties and good pharmacological characteristics...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27834725/do-gadolinium-based-contrast-agents-affect-the-18f-fdg-pet-ct-uptake-in-the-dentate-nucleus-and-the-globus-pallidus-a-pilot-study
#7
Kyle Bauer, Alaina Lathrum, Osama Raslan, Patrick Kelly, Yihua Zhou, Debra Hewing, Crystal Botkin, James Turner, Medhat M Osman
OBJECTIVES: Gadolinium (Gd) is toxic and to avoid its deposition in the tissues, it must be chemically bonded with nonmetal ions to facilitate its excretion by the kidneys. High signal intensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted MR images has been both morphologically and pathologically linked to gadolinium-based contrast agent (GBCA) retention in the brain. The purpose of this study is to determine if repeated administrations of GBCA would affect the uptake of (18)F-FDG in the DN and GP on PET/CT...
November 10, 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27693607/gadolinium-toxicity-and-treatment
#8
Joana Ramalho, Miguel Ramalho, Michael Jay, Lauren Burke, Richard C Semelka
GBCAs play an important role in the diagnostic evaluation of many patients. The safety of these agents has been once again questioned after gadolinium deposits were observed and measured in brain and bone of patients with normal renal function. This retention of gadolinium in the human body has been termed "gadolinium storage condition". The long- term and cumulative effects of retained gadolinium in the brain and elsewhere are not as yet understood. Recently, patients who report that they suffer from chronic symptoms secondary to gadolinium exposure and retention created gadolinium-toxicity on-line support groups...
September 27, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27620882/ang1005-for-breast-cancer-brain-metastases-correlation-between-18-f-flt-pet-after-first-cycle-and-mri-in-response-assessment
#9
C C O'Sullivan, M Lindenberg, C Bryla, N Patronas, C J Peer, L Amiri-Kordestani, N Davarpanah, E M Gonzalez, M Burotto, P Choyke, S M Steinberg, D J Liewehr, W D Figg, T Fojo, S Balasubramaniam, S E Bates
PURPOSE: Improved therapies and imaging modalities are needed for the treatment of breast cancer brain metastases (BCBM). ANG1005 is a drug conjugate consisting of paclitaxel covalently linked to Angiopep-2, designed to cross the blood-brain barrier. We conducted a biomarker substudy to evaluate (18)F-FLT-PET for response assessment. METHODS: Ten patients with measurable BCBM received ANG1005 at a dose of 550 mg/m(2) IV every 21 days. Before and after cycle 1, patients underwent PET imaging with (18)F-FLT, a thymidine analog, retention of which reflects cellular proliferation, for comparison with gadolinium-contrast magnetic resonance imaging (Gd-MRI) in brain metastases detection and response assessment...
November 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27607169/18f-fdg-pet-ct-imaging-of-cauda-equina-syndrome-secondary-to-leptomeningeal-metastatic-breast-cancer
#10
Lilja B Solnes, Mehrbod S Javadi, Steven P Rowe
Cauda equina syndrome (CES) is an uncommon entity that may be caused by a variety of conditions. It refers to dysfunction of the ventral, dorsal, sacral, and coccygeal nerve roots in the region of the filum terminale. We present a case of a 32-year-old woman with a history of BRCA1-positive metastatic breast cancer who complained of lower extremity muscle weakness increasing over a 2-week period and decreased sensation of the lower extremities accompanied by severe constipation and suspected urinary retention with overflow incontinence...
November 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27509542/spinal-cord-inflammation-molecular-imaging-after-thoracic-aortic-ischemia-reperfusion-injury
#11
Hassan Albadawi, John W Chen, Rahmi Oklu, Yue Wu, Gregory Wojtkiewicz, Benjamin Pulli, John D Milner, Richard P Cambria, Michael T Watkins
Purpose To evaluate whether noninvasive molecular imaging technologies targeting myeloperoxidase (MPO) can reveal early inflammation associated with spinal cord injury after thoracic aortic ischemia-reperfusion (TAR) in mice. Materials and Methods The study was approved by the institutional animal care and use committee. C57BL6 mice that were 8-10 weeks old underwent TAR (n = 55) or sham (n = 26) surgery. Magnetic resonance (MR) imaging (n = 6) or single photon emission computed tomography (SPECT)/computed tomography (CT) (n = 15) studies targeting MPO activity were performed after intravenous injection of MPO sensors (bis-5-hydroxytryptamide-tetraazacyclododecane [HT]-diethyneletriaminepentaacetic acid [DTPA]-gadolinium or indium 111-bis-5-HT-DTPA, respectively)...
January 2017: Radiology
https://www.readbyqxmd.com/read/27469211/pediatric-patients-demonstrate-progressive-t1-weighted-hyperintensity-in-the-dentate-nucleus-following-multiple-doses-of-gadolinium-based-contrast-agent
#12
D R Roberts, A R Chatterjee, M Yazdani, B Marebwa, T Brown, H Collins, G Bolles, J M Jenrette, P J Nietert, X Zhu
BACKGROUND AND PURPOSE: While there have been recent reports of brain retention of gadolinium following gadolinium-based contrast agent administration in adults, a retrospective series of pediatric patients has not previously been reported, to our knowledge. We investigated the relationship between the number of prior gadolinium-based contrast agent doses and increasing T1 signal in the dentate nucleus on unenhanced T1-weighted MR imaging. We hypothesized that despite differences in pediatric physiology and the smaller gadolinium-based contrast agent doses that pediatric patients are typically administered based on weighted-adjusted dosing, the pediatric brain would also demonstrate dose-dependent increasing T1 signal in the dentate nucleus...
December 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27459250/distribution-and-clearance-of-retained-gadolinium-in-the-brain-differences-between-linear-and-macrocyclic-gadolinium-based-contrast-agents-in-a-mouse-model
#13
A Adhipatria P Kartamihardja, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima
OBJECTIVE: To investigate the distribution and clearance of retained gadolinium (Gd) in various parts of the brain after intravenously administering a Gd-based contrast agent (GBCA) in normal and renal failure mouse models. METHODS: Two different mouse models: normal (n = 12) and renal failure (n = 12) were used. Clinical GBCAs (Gd-DTPA-BMA, 5 mmol kg(-1), or Gd-DOTA, 5 mmol kg(-1)) were intravenously administered five times per week for 4 weeks...
October 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27309776/iron-iii-based-magnetic-resonance-imageable-liposomal-t1-contrast-agent-for-monitoring-temperature-induced-image-guided-drug-delivery
#14
Esther Kneepkens, Adriana Fernandes, Klaas Nicolay, Holger Grüll
OBJECTIVES: Drug-loaded temperature-sensitive liposomes (TSLs) allow heat-triggered local drug delivery to tumors. When magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is applied to heat up the tumor, corelease of a drug together with an MR contrast agent (CA) from TSLs allows for indirect imaging of the drug release with MR imaging. However, liposomal encapsulation of commonly used gadolinium (Gd)-based MR CAs leads to prolonged retention times in the liver and spleen, which could lead to a transmetallation and redistribution of Gd to other organs...
June 15, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27299580/impact-of-impaired-renal-function-on-gadolinium-retention-after-administration-of-gadolinium-based-contrast-agents-in-a-mouse-model
#15
A Adhipatria P Kartamihardja, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima
OBJECTIVES: The aim of this study was to investigate the impact of impaired renal function on gadolinium (Gd) retention in various organs after Gd-based contrast agent injection. MATERIALS AND METHODS: After local animal care and review committee approval, 23 normal mice and 26 with renal failure were divided into 4 treatment groups (Gd-DTPA-BMA, 5 mmol/kg; Gd-DOTA, 5 mmol/kg; GdCl3, 0.02 mmol/kg; and saline, 250 μL). Each agent was intravenously administered on weekdays for 4 weeks...
October 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27282825/increased-signal-intensities-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-images-evidence-in-children-undergoing-multiple-gadolinium-mri-exams
#16
Houchun H Hu, Amber Pokorney, Richard B Towbin, Jeffrey H Miller
BACKGROUND: Recent reports have suggested residual gadolinium deposition in the brain in subjects undergoing multiple contrast-enhanced MRI exams. These findings have raised some concerns regarding gadolinium-based contrast agent (GBCA) usage and retention in brain tissues. OBJECTIVE: To summarize findings of hyperintense brain structures on precontrast T1-weighted images in 21 children undergoing multiple GBCA MRI exams. MATERIALS AND METHODS: This retrospective study involved 21 patients, each of whom received multiple MRI examinations (range: 5-37 exams) with GBCA over the course of their medical treatment (duration from first to most recent exam: 1...
October 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27175546/revisiting-the-pharmacokinetic-profiles-of-gadolinium-based-contrast-agents-differences-in-long-term-biodistribution-and-excretion
#17
Eric Lancelot
OBJECTIVES: Gadolinium-based contrast agents (GBCAs) have been used for years for magnetic resonance imaging examinations. Because of their rapid blood clearance, they were considered as very safe products until some of them were shown to induce nephrogenic systemic fibrosis in patients with renal failure and hypersignals on T1-weighted unenhanced brain scans of patients with normal renal function. To date, these adverse effects have been related almost exclusively to the use of low-stability linear agents, which are more prone to release free gadolinium...
November 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27113247/t1-weighted-mr-imaging-of-liver-tumor-by-gadolinium-encapsulated-glycol-chitosan-nanoparticles-without-non-specific-toxicity-in-normal-tissues
#18
Jin Hee Na, Sangmin Lee, Heebeom Koo, Hyounkoo Han, Kyung Eun Lee, Seung Jin Han, Seung Hong Choi, Hyuncheol Kim, Seulki Lee, Ick Chan Kwon, Kuiwon Choi, Kwangmeyung Kim
Herein, we have synthesized Gd(iii)-encapsulated glycol chitosan nanoparticles (Gd(iii)-CNPs) for tumor-targeted T1-weighted magnetic resonance (MR) imaging. The T1 contrast agent, Gd(iii), was successfully encapsulated into 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-modified CNPs to form stable Gd(iii)-encapsulated CNPs (Gd(iii)-CNPs) with an average particle size of approximately 280 nm. The stable nanoparticle structure of Gd(iii)-CNPs is beneficial for liver tumor accumulation by the enhanced permeation and retention (EPR) effect...
May 5, 2016: Nanoscale
https://www.readbyqxmd.com/read/27097822/synergistic-effect-of-human-serum-albumin-and-fullerene-on-gd-do3a-for-tumor-targeting-imaging
#19
Ying Zhang, Toujun Zou, Mirong Guan, Mingming Zhen, Daiqin Chen, Xiangping Guan, Hongbin Han, Chunru Wang, Chunying Shu
A macromolecular magnetic resonance imaging (MRI) contrast agent was successfully synthesized by conjugating the gadolinium/1,4,7,10-tetraazacyclododecane-1,4,7-tetracetic acid complex (Gd-DO3A) with 6,6-phenyl-C61 butyric acid (PC61BA) and upon further modification with human serum albumin (HSA). The final product, PC61BA-(Gd-DO3A)/HSA, has a high stability and exhibits a much higher relaxivity (r1 = 89.1 mM(-1) s(-1) at 0.5 T, 300 K) than Gd-DO3A (r1 = 4.7 mM(-1) s(-1)) does under the same condition, producing the synergistic positive effect of HSA and C60 on the relaxivity of Gd-DO3A...
May 11, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27054693/increased-signal-intensity-in-the-dentate-nucleus-of-patients-with-multiple-sclerosis-in-comparison-with-neuromyelitis-optica-spectrum-disorder-after-multiple-doses-of-gadolinium-contrast
#20
COMPARATIVE STUDY
Masami Tanaka, Kazuki Nakahara, Masako Kinoshita
AIMS: This study was conducted to compare the effect of linear gadolinium-based contrast agents in the retention in the cerebellar dentate nucleus of patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOsd). METHODS: The signal intensity ratio of the pons to the cerebellar dentate nucleus was measured on T1-weighted MRI scans of the brain in 21 MS patients and 6 NMOsd patients given at least 10 doses of gadolinium. Linear regression analysis of the number of doses was then conducted for each patient...
2016: European Neurology
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