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Gadolinium retention

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https://www.readbyqxmd.com/read/29155619/gadolinium-retention-and-deposition-revisited-how-the-chemical-properties-of-gadolinium-based-contrast-agents-and-the-use-of-animal-models-inform-us-about-the-behavior-of-these-agents-in-the-human-brain
#1
https://www.readbyqxmd.com/read/29117483/a-manganese-based-alternative-to-gadolinium-contrast-enhanced-mr-angiography-excretion-pharmacokinetics-and-metabolism
#2
Eric M Gale, Hsiao-Ying Wey, Ian Ramsay, Yi-Fen Yen, David E Sosnovik, Peter Caravan
Purpose To compare intravascular contrast enhancement produced by the manganese-based magnetic resonance (MR) imaging contrast agent manganese-N-picolyl-N,N',N'-trans-1,2-cyclohexenediaminetriacetate (Mn-PyC3A) to gadopentetate dimeglumine (Gd-DTPA) and to evaluate the excretion, pharmacokinetics, and metabolism of Mn-PyC3A. Materials and Methods Contrast material-enhanced MR angiography was performed in baboons (Papio anubis; n = 4) by using Mn-PyC3A and Gd-DTPA. Dynamic imaging was performed for 60 minutes following Mn-PyC3A injection to monitor distribution and elimination...
November 8, 2017: Radiology
https://www.readbyqxmd.com/read/29110904/retention-of-gadolinium-compounds-used-in-magnetic-resonance-imaging-a-critical-review-and-the-recommendations-of-regulatory-agencies
#3
L Martí-Bonmatí, E Martí-Bonmatí
The Spanish Agency for Drugs and Healthcare Products (AEMPS), based on the recommendations of the European Committee for Risk Assessment in Pharmacovigilance, established on 13 March 2017 that linear gadolinium-based MR contrast media, such as MultiHance, Omniscan, Magnevist (currently not marketed) and Optimark (no longer marketed in Spain), the clinical benefits do not outweigh the potential risks derived from their use. AEMPS recommends to suspend its marketing for general use based on the retention of these compounds in the brain...
October 27, 2017: Radiología
https://www.readbyqxmd.com/read/29071187/gadolinium-and-platinum-in-tandem-real-time-multi-modal-monitoring-of-drug-delivery-by-mri-and-fluorescence-imaging
#4
Hongguang Li, Bethany I Harriss, Alkystis Phinikaridou, Sara Lacerda, Gregory Ramniceanu, Bich-Thuy Doan, Ka-Lok Ho, Chi-Fai Chan, Wai-Sum Lo, René M Botnar, Rongfeng Lan, Cyrille Richard, Ga-Lai Law, Nicholas J Long, Ka-Leung Wong
A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM(-1)s(-1) at 3T, 25 (o)C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29063255/gadolinium-retention-after-administration-of-contrast-agents-based-on-linear-chelators-and-the-recommendations-of-the-european-medicines-agency
#5
EDITORIAL
Ilona A Dekkers, Rick Roos, Aart J van der Molen
The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) earlier this year recommended to suspend some marketing authorisations for Gadolinium Containing Contrast Agents (GCCAs) based on linear chelators due to the potential risk of gadolinium retention in the human body. These recommendations have recently been re-evaluated by EMA's Committee for Medicinal Products for Human Use (CHMP), and confirmed the final opinion of the European Medicines Agency. This editorial provides an overview of the available GCCAs and summarises the recent evidence of gadolinium retention...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29038383/biological-effects-of-mri-contrast-agents-gadolinium-retention-potential-mechanisms-and-a-role-for-phosphorus
#6
REVIEW
Joel Garcia, Stephen Z Liu, Angelique Y Louie
No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room-which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens...
November 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28990973/the-issue-of-gadolinium-retained-in-tissues-insights-on-the-role-of-metal-complex-stability-by-comparing-metal-uptake-in-murine-tissues-upon-the-concomitant-administration-of-lanthanum-and-gadolinium-diethylentriamminopentaacetate
#7
Enza Di Gregorio, Giuseppe Ferrauto, Chiara Furlan, Stefania Lanzardo, Raffaele Nuzzi, Eliana Gianolio, Silvio Aime
OBJECTIVES: The aim of the study was to explore the role of the stability of metal complexes in the processes that lead to the metal retention in the brain and other tissues of mice administered with lanthanides-based contrast agents. This issue was tackled by the simultaneous injection of gadolinium (Gd)-diethylentriamminopentaacetate (DTPA) and lanthanum-DTPA, which have the same charge and structure but differ in their thermodynamic stability by 3 orders of magnitude. MATERIALS AND METHODS: A total of 20 healthy BALB/c mice were administered by a single intravenous injection with a dose consisting of 0...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28964466/gadolinium-deposition-and-chronic-toxicity
#8
REVIEW
Joana Ramalho, Miguel Ramalho
Clinicians, radiologists, and patients should be aware of the most up-to-date data on the risks of gadolinium-based contrast agent (GBCA) administration. In this review, we discuss in vivo gadolinium retention, particularly brain tissue retention, and potential toxic effects. GBCA pharmacokinetics and biodistribution are reviewed briefly. Based on the more recent published literature and society guidelines, general safety recommendations for clinical practice are provided.
November 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28952018/effects-of-serial-macrocyclic-based-contrast-materials-gadoterate-meglumine-and-gadobutrol-administrations-on-gadolinium-related-dentate-nuclei-signal-increases-in-unenhanced-t1-weighted-brain-a-retrospective-study-in-158-multiple-sclerosis-ms-patients
#9
Alessandra Splendiani, Marco Perri, Claudia Marsecano, Valentina Vellucci, Giulia Michelini, Antonio Barile, Ernesto Di Cesare
PURPOSE: To perform T1 signal intensity (SI) measurements in the dentate nuclei of adult patients with confirmed multiple sclerosis (MS) after serial administrations of the macrocyclic gadolinium-based contrast agents (GBCAs), gadoterate meglumine and gadobutrol. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and informed consent was waived. A review of our PACS database for the period from March 1, 2007 to July 31, 2016 revealed 158 confirmed MS patients who received exclusively either gadoterate meglumine (n = 81) or gadobutrol (n = 77) for diagnosis and follow-up...
September 27, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28933214/magnetic-enhancement-of-stem-cell-targeted-delivery-into-the-brain-following-mr-guided-focused-ultrasound-for-opening-the-blood-brain-barrier
#10
Wei-Bin Shen, Pavlos Anastasiadis, Ben Nguyen, Deborah Yarnell, Paul J Yarowsky, Victor Frenkel, Paul S Fishman
Focused ultrasound (FUS)-mediated blood-brain barrier disruption (BBBD) can enable even large therapeutics such as stem cells to enter the brain from the bloodstream. However, the efficiency is relatively low. Our previous study showed that human neural progenitor cells (hNPCs) loaded with superparamagnetic iron oxide nanoparticles (SPIONs) in culture were attracted by an external magnetic field. In vivo, enhanced brain retention was observed near a magnet mounted on the skull in a rat model of traumatic brain injury, where BBBD also occurs...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28915162/the-effect-of-perinatal-gadolinium-based-contrast-agents-on-adult-mice-behavior
#11
Miski Aghnia Khairinisa, Yusuke Takatsuru, Izuki Amano, Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima, Noriyuki Koibuchi
OBJECTIVES: The aim of this study was to examine the effects of perinatal exposure to gadolinium (Gd)-based contrast agents (GBCAs) on the behavior of adulthood offspring. MATERIALS AND METHODS: Pregnant Balb/C mice (n = 5 per group) were intravenously injected with gadoterate meglumine (Magnescope, macrocyclic GBCA), gadodiamide (Omniscan, linear GBCA), or vehicle from pregnancy day 15 to 19, corresponding to embryonic day 15 to 19 of the fetus, at 2 mmol/kg body weight per day...
September 14, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28875472/evaluation-of-novel-64-cu-labeled-theranostic-gadolinium-based-nanoprobes-in-hepg2-tumor-bearing-nude-mice
#12
Pengcheng Hu, Dengfeng Cheng, Tao Huang, Anna B Banizs, Jie Xiao, Guobing Liu, Quan Chen, Yuenan Wang, Jiang He, Hongcheng Shi
Radiation therapy of liver cancer is limited by low tolerance of the liver to radiation. Radiosensitizers can effectively reduce the required radiation dose. AGuIX nanoparticles are small, multifunctional gadolinium-based nanoparticles that can carry radioisotopes or fluorescent markers for single-photon emission computed tomography (SPECT), positron emission tomography (PET), fluorescence imaging, and even multimodality imaging. In addition, due to the high atomic number of gadolinium, it can also serve as a tumor radiation sensitizer...
September 6, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28873047/gadolinium-retention-in-the-rat-brain-assessment-of-the-amounts-of-insoluble-gadolinium-containing-species-and-intact-gadolinium-complexes-after-repeated-administration-of-gadolinium-based-contrast-agents
#13
Eliana Gianolio, Paola Bardini, Francesca Arena, Rachele Stefania, Enza Di Gregorio, Rebecca Iani, Silvio Aime
Purpose To evaluate the speciation of gadolinium-containing species after multiple administrations of the gadolinium-based contrast agents (GBCAs) gadodiamide and gadoteridol and to quantify the amount of intact gadolinium complexes and insoluble gadolinium-containing species. Materials and Methods A total dose of 13.2 mmol per kilogram of body weight of each GBCA was administered in healthy Wistar rats over a period of 8 weeks. Three days after the final administration, rats were sacrificed, and the brains were excised and divided into three portions...
December 2017: Radiology
https://www.readbyqxmd.com/read/28742734/evaluation-of-gadolinium-retention-after-serial-administrations-of-a-macrocyclic-gadolinium-based-contrast-agent-gadobutrol-a-single-institution-experience-with-189-patients
#14
Roh-Eul Yoo, Chul-Ho Sohn, Koung Mi Kang, Tae Jin Yun, Seung Hong Choi, Ji-Hoon Kim, Sun-Won Park
OBJECTIVE: There has been controversy as to whether gadobutrol, one of the widely used macrocyclic gadolinium-based contrast agents, can lead to gadolinium retention after serial injections. Our aim was to validate whether serial administrations of gadobutrol can cause signal increase in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images due to gadolinium retention. MATERIALS AND METHODS: A total of 189 patients who had undergone at least 2 contrast-enhanced MR scans using only gadobutrol between August 2009 and August 2016 were retrospectively included...
July 24, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28730643/differences-in-gadolinium-retention-after-repeated-injections-of-macrocyclic-mr-contrast-agents-to-rats
#15
Simona Bussi, Alessandra Coppo, Catherine Botteron, Valérie Fraimbault, Antonello Fanizzi, Elisa De Laurentiis, Sonia Colombo Serra, Miles A Kirchin, Fabio Tedoldi, Federico Maisano
PURPOSE: To compare the levels of gadolinium in the blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposure of rats to the macrocyclic gadolinium-based contrast agents (GBCAs) gadoterate, gadobutrol, and gadoteridol. MATERIALS AND METHODS: Fifty male Wistar Han rats were randomized to three exposure groups (n = 15 per group) and one control group (n = 5). Animals in the exposure groups received a total of 20 GBCA administrations (four administrations per week for 5 consecutive weeks) at a dose of 0...
July 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28730467/organ-retention-of-gadolinium-in-mother-and-pup-mice-effect-of-pregnancy-and-type-of-gadolinium-based-contrast-agents
#16
Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Miski Aghnia Khairinisa, Oyunbold Lamid-Ochir, Amartuvshin Tumenjargal, Noriyuki Koibuchi, Hiroshi Koyama, Yoshito Tsushima
PURPOSE: To investigate the effect of pregnancy and type of gadolinium (Gd)-based contrast agents (GBCAs) on organ retention of Gd in mother and pup mice after maternal administration. MATERIALS AND METHODS: Gd-DTPA-BMA (gadodiamide) or Gd-DOTA (gadoterate dimeglumine) was administered (2.0 mmol/kg of maternal weight) four times to pregnant Balb/c mice from gestational day 16-19, respectively. At 28 days after birth, they were euthanized and their organs (blood, brain, liver, kidney, spleen, and bone) were removed for the measurement of Gd by inductively coupled plasma mass spectrometry...
October 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28718023/two-year-survey-of-specific-hospital-wastewater-treatment-and-its-impact-on-pharmaceutical-discharges
#17
Laure Wiest, Teofana Chonova, Alexandre Bergé, Robert Baudot, Frédérique Bessueille-Barbier, Linda Ayouni-Derouiche, Emmanuelle Vulliet
It is well known that pharmaceuticals are not completely removed by conventional activated sludge wastewater treatment plants. Hospital effluents are of major concern, as they present high concentrations of pharmaceutically active compounds. Despite this, these specific effluents are usually co-treated with domestic wastewaters. Separate treatment has been recommended. However, there is a lack of information concerning the efficiency of separate hospital wastewater treatment by activated sludge, especially on the removal of pharmaceuticals...
July 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28694590/spinal-angiolipomas-a-puzzling-case-and-review-of-a-rare-entity
#18
REVIEW
Faris Shweikeh, Ajleeta Sangtani, Michael P Steinmetz, Peter Zahos, Bohdan Chopko
Patients with spinal epidural abscesses (SEAs) may have a variable presentation. Such an infection has a typical appearance on magnetic resonance imaging (MRI) and enhances with gadolinium. We present a case that was a diagnostic challenge where pre- and intra-operative findings resulted in conflicting impressions. The mimicker was a spinal angiolipoma (SAL). The authors then provide a thorough review of this rare spinal neoplasm. A 55-year-old man presented with back pain, paresis, paresthesia, and urinary retention...
April 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28653180/regional-interaction-between-myocardial-sympathetic-denervation-contractile-dysfunction-and-fibrosis-in-heart-failure-with-preserved-ejection-fraction-11-c-hydroxyephedrine-pet-study
#19
Tadao Aikawa, Masanao Naya, Masahiko Obara, Noriko Oyama-Manabe, Osamu Manabe, Keiichi Magota, Yoichi M Ito, Chietsugu Katoh, Nagara Tamaki
PURPOSE: This investigation aimed to identify significant predictors of regional sympathetic denervation quantified by (11)C-hydroxyephedrine (HED) positron emission tomography (PET) in patients with heart failure with preserved left ventricular ejection fraction (HFpEF). METHODS: Included in the study were 34 patients (age 63 ± 15 years, 23 men) with HFpEF (left ventricular ejection fraction ≥40%) and 11 age-matched volunteers without heart failure. Cardiac magnetic resonance imaging was performed to measure left ventricular size and function, and the extent of myocardial late gadolinium enhancement (LGE)...
June 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28642266/t1-signal-measurements-in-pediatric-brain-findings-after-multiple-exposures-to-gadobenate-dimeglumine-for-imaging-of-nonneurologic-disease
#20
G K Schneider, J Stroeder, G Roditi, C Colosimo, P Armstrong, M Martucci, A Buecker, P Raczeck
BACKGROUND AND PURPOSE: Signal intensity increases possibly suggestive of gadolinium retention have recently been reported on unenhanced T1-weighted images of the pediatric brain following multiple exposures to gadolinium-based MR contrast agents. Our aim was to determine whether T1 signal changes suggestive of gadolinium deposition occur in the brains of pediatric nonneurologic patients after multiple exposures to gadobenate dimeglumine. MATERIALS AND METHODS: Thirty-four nonneurologic patients (group 1; 17 males/17 females; mean age, 7...
June 22, 2017: AJNR. American Journal of Neuroradiology
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