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Gadolinium retention

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https://www.readbyqxmd.com/read/28642266/t1-signal-measurements-in-pediatric-brain-findings-after-multiple-exposures-to-gadobenate-dimeglumine-for-imaging-of-nonneurologic-disease
#1
G K Schneider, J Stroeder, G Roditi, C Colosimo, P Armstrong, M Martucci, A Buecker, P Raczeck
BACKGROUND AND PURPOSE: Signal intensity increases possibly suggestive of gadolinium retention have recently been reported on unenhanced T1-weighted images of the pediatric brain following multiple exposures to gadolinium-based MR contrast agents. Our aim was to determine whether T1 signal changes suggestive of gadolinium deposition occur in the brains of pediatric nonneurologic patients after multiple exposures to gadobenate dimeglumine. MATERIALS AND METHODS: Thirty-four nonneurologic patients (group 1; 17 males/17 females; mean age, 7...
June 22, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28627037/quantitative-gd-dota-uptake-from-cerebrospinal-fluid-into-rat-brain-using-3d-vfa-spgr-at-9-4t
#2
Hedok Lee, Kristian Mortensen, Simon Sanggaard, Palle Koch, Hans Brunner, Bjørn Quistorff, Maiken Nedergaard, Helene Benveniste
PURPOSE: We propose a quantitative technique to assess solute uptake into the brain parenchyma based on dynamic contrast-enhanced MRI (DCE-MRI). With this approach, a small molecular weight paramagnetic contrast agent (Gd-DOTA) is infused in the cerebral spinal fluid (CSF) and whole brain gadolinium concentration maps are derived. METHODS: We implemented a 3D variable flip angle spoiled gradient echo (VFA-SPGR) longitudinal relaxation time (T1) technique, the accuracy of which was cross-validated by way of inversion recovery rapid acquisition with relaxation enhancement (IR-RARE) using phantoms...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28501081/the-impact-of-excess-ligand-on-the-retention-of-nonionic-linear-gadolinium-based-contrast-agents-in-patients-with-various-levels-of-renal-dysfunction-a-review-and-simulation-analysis
#3
REVIEW
John P Prybylski, Michael Jay
The role of gadolinium (Gd)-based contrast agents (GBCAs) in the pathophysiology of nephrogenic systemic fibrosis (NSF) is now uncontested. Although the definitive mechanism has not been established, the association with weaker GBCA ligands and with reduced renal clearance supports a hypothesis that Gd release from the GBCAs is a key process in precipitating the disease. Prevention strategies often include the use of more stable GBCA ligands in patients with reduced kidney function, but animal models and some clinical data suggest that better patient outcomes can be achieved when excess ligand is administered with weaker GBCAs; this is particularly significant for OptiMARK, which contains a nonionic, linear ligand similar to gadodiamide, the active ingredient in Omniscan, but contains twice the amount of excess ligand...
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28501075/gadolinium-retention-and-toxicity-an-update
#4
REVIEW
Miguel Ramalho, Joana Ramalho, Lauren M Burke, Richard C Semelka
Until 2006, the main considerations regarding safety for all gadolinium-based contrast agents (GBCAs) were related to short-term adverse reactions. However, the administration of certain "high-risk" GBCAs to patients with renal failure resulted in multiple reported cases of nephrogenic systemic fibrosis. Findings have been reported regarding gadolinium deposition within the body and various reports of patients who report suffering from acute and chronic symptoms secondary to GBCA's exposure. At the present state of knowledge, it has been proved that gadolinium deposits also occur in the brain, irrespective of renal function and GBCAs stability class...
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28495943/retention-of-gadolinium-based-contrast-agents-in-multiple-sclerosis-retrospective-analysis-of-an-18-year-longitudinal-study
#5
Y Forslin, S Shams, F Hashim, P Aspelin, G Bergendal, J Martola, S Fredrikson, M Kristoffersen-Wiberg, T Granberg
BACKGROUND AND PURPOSE: Gadolinium-based contrast agents have been associated with lasting high T1-weighted signal intensity in the dentate nucleus and globus pallidus, with histopathologically confirmed gadolinium retention. We aimed to longitudinally investigate the relationship of multiple gadolinium-based contrast agent administrations to the Signal Intensity Index in the dentate nucleus and globus pallidus and any associations with cognitive function in multiple sclerosis. MATERIALS AND METHODS: The Signal Intensity Index in the dentate nucleus and globus pallidus was retrospectively evaluated on T1-weighted MR imaging in an 18-year longitudinal cohort study of 23 patients with MS receiving multiple gadolinium-based contrast agent administrations and 23 healthy age- and sex-matched controls...
May 11, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28481080/quantitative-molecular-imaging-with-a-single-gd-based-contrast-agent-reveals-specific-tumor-binding-and-retention-in-vivo
#6
Mette L Johansen, Ying Gao, Melanie A Hutnick, Sonya E L Craig, Jonathan K Pokorski, Chris A Flask, Susann M Brady-Kalnay
Magnetic resonance imaging (MRI) has become an indispensable tool in the diagnosis and treatment of many diseases, especially cancer. However, the poor sensitivity of MRI relative to other imaging modalities, such as PET, has hindered the development and clinical use of molecular MRI contrast agents that could provide vital diagnostic information by specifically locating a molecular target altered in the disease process. This work describes the specific and sustained in vivo binding and retention of a protein tyrosine phosphatase mu (PTPμ)-targeted, molecular magnetic resonance (MR) contrast agent with a single gadolinium (Gd) chelate using a quantitative MRI T1 mapping technique in glioma xenografts...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28371515/spherical-polyelectrolyte-brushes-as-a-novel-platform-for-paramagnetic-relaxation-enhancement-and-passive-tumor-targeting
#7
Qin Zhu, Zhenyu Yuan, Weiqiao Qian, Yuanyuan Li, Zhiqiang Qiu, Weijun Tang, Jie Wang, Yun Ding, Aiguo Hu
A novel platform for the development of highly efficient magnetic resonance imaging (MRI) contrast agents has been demonstrated. New contrast agents are designed and produced through electrostatic self-assembly of cationic gadolinium(III) complexes onto anionic spherical polyelectrolyte brushes (SPB). The structurally well-defined SPB are composed of polystyrene core and polyacrylic acid brush layer, where numerous binding sites and confined microenvironments are available for the embedment of the gadolinium(III) contrast agents...
June 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28361260/gadolinium-retention-in-the-body-what-we-know-and-what-we-can-do
#8
REVIEW
Enrico Tedeschi, Ferdinando Caranci, Flavio Giordano, Valentina Angelini, Sirio Cocozza, Arturo Brunetti
Gadolinium-based contrast agents (GBCA), widely used in Magnetic Resonance Imaging (MRI) for almost 30 years, were recently shown to be deposited in the brain and to induce persistent T1 shortening in deep gray matter structures in subjects with normal renal function. The aim of the present study is to summarize the evidence derived from the rapidly growing scientific literature on Gadolinium retention in the brain and in the rest of the body. To this end, the original articles that described imaging and pathology findings in humans and animals exposed to GBCA were reviewed...
March 30, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28283728/survey-of-gadolinium-based-contrast-agent-utilization-among-the-members-of-the-society-for-pediatric-radiology-a-quality-and-safety-committee-report
#9
Einat Blumfield, Michael M Moore, Mary K Drake, Thomas R Goodman, Kristopher N Lewis, Laura T Meyer, Thang D Ngo, Christina Sammet, Arta Luana Stanescu, David W Swenson, Thomas L Slovis, Ramesh S Iyer
BACKGROUND: Gadolinium-based contrast agents (GBCAs) have been used for magnetic resonance (MR) imaging over the last three decades. Recent reports demonstrated gadolinium retention in patients' brains following intravenous administration. Since gadolinium is a highly toxic heavy metal, there is a potential for adverse effects from prolonged retention or deposition, particularly in children. For this reason, the Society (SPR) for Pediatric Radiology Quality and Safety committee conducted a survey to evaluate the current status of GBCAs usage among pediatric radiologists...
May 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28266269/liposomal-nanotechnology-for-cancer-theranostics
#10
Zhifei Dai, Xiuli Yue
Liposomes are a type of biomimetic nanoparticles generated from self-assembling concentric lipid bilayer enclosing an aqueous core domain. They have been attractive nanocarriers for the delivery of many drugs (e.g. radiopharmaceuticals, chemotherapeutic agents, porphyrin) and diagnostic agents (e.g. fluorescent dyes, quantum dots, Gadolinium complex and Fe3O4) by encapsulating (or adsorbing) hydrophilic one inside the liposomal aqueous core domain (or on the bilayer membrane surface), and by entrapping hydrophobic one within the liposomal bilayer...
March 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28221807/mechanostereoselective-one-pot-synthesis-of-functionalized-head-to-head-cyclodextrin-3-rotaxanes-and-their-application-as-magnetic-resonance-imaging-contrast-agents
#11
Jean Wilfried Fredy, Jérémy Scelle, Gregory Ramniceanu, Bich-Thuy Doan, Célia S Bonnet, Éva Tóth, Mickaël Ménand, Matthieu Sollogoub, Guillaume Vives, Bernold Hasenknopf
A versatile, five-component, one-pot synthesis of cyclodextrin (CD) [3]rotaxanes using copper-catalyzed azide-alkyne cycloaddition has been developed. Head-to-head [3]rotaxanes of α-CD selectively functionalized by one or two gadolinium 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid monoamide complexes were obtained mechanostereoselectively. The magnetic resonance imaging efficiency, expressed by the longitudinal proton relaxivity of the rotaxanes, was significantly improved as compared to the functionalized CD...
February 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28125438/quantification-and-assessment-of-the-chemical-form-of-residual-gadolinium-in-the-brain-after-repeated-administration-of-gadolinium-based-contrast-agents-comparative-study-in-rats
#12
Thomas Frenzel, Chirag Apte, Gregor Jost, Laura Schöckel, Jessica Lohrke, Hubertus Pietsch
OBJECTIVE: Multiple clinical and preclinical studies have reported a signal intensity increase and the presence of gadolinium (Gd) in the brain after repeated administration of Gd-based contrast agents (GBCAs). This bioanalytical study in rat brain tissue was initiated to investigate whether the residual Gd is present as intact GBCA or in other chemical forms by using tissue fractionation and chromatography. MATERIALS AND METHODS: Rats were divided randomly in 6 groups of 10 animals each...
July 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28076722/is-there-long-term-signal-intensity-increase-in-the-central-nervous-system-on-t1-weighted-images-after-mr-imaging-with-the-hepatospecific-contrast-agent-gadoxetic-acid-a-cross-sectional-study-in-91-patients
#13
Johannes Kahn, Helena Posch, Ingo G Steffen, Dominik Geisel, Christian Bauknecht, Thomas Liebig, Timm Denecke
Purpose To evaluate whether there is T1-weighted signal intensity (SI) increase in the dentate nucleus (DN) and globus pallidus (GP) in relation to the middle cerebellar peduncle (MCP), pons, and thalamus after repeated administration of the liver-specific contrast agent gadoxetic acid. Materials and Methods This was an institutional review board-approved, prospectively conducted (written informed consent acquired), cross-sectional study performed in a consecutively selected patient group (n = 91; patients received one to 37 doses of gadoxetic acid) and a control group (n = 52; subjects had never received injections of gadolinium-based contrast agent) examined with a standard T1-weighted two-dimensional spin-echo pulse sequence of the brain at 1...
March 2017: Radiology
https://www.readbyqxmd.com/read/28060285/preparation-and-in-vitro-characterization-of-dendrimer-based-contrast-agents-for-magnetic-resonance-imaging
#14
Serhat Gündüz, Tanja Savić, Đorđe Toljić, Goran Angelovski
Paramagnetic complexes of gadolinium(III) with acyclic or macrocyclic chelates are the most commonly used contrast agents (CAs) for magnetic resonance imaging (MRI). Their purpose is to enhance the relaxation rate of water protons in tissue, thus increasing the MR image contrast and the specificity of the MRI measurements. Current clinically approved contrast agents are low molecular weight molecules that are rapidly cleared from the body. The use of dendrimers as carriers of paramagnetic chelators can play an important role in the future development of more efficient MRI contrast agents...
December 4, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28005498/gadolinium-retention-in-the-body-and-brain-is-it-time-for-an-international-joint-research-effort
#15
Carlo Cosimo Quattrocchi, Aart J van der Molen
No abstract text is available yet for this article.
January 2017: Radiology
https://www.readbyqxmd.com/read/27987464/confirming-improved-detection-of-gadolinium-in-bone-using-in-vivo-xrf
#16
M L Lord, F E McNeill, J L Gräfe, A L Galusha, P J Parsons, M D Noseworthy, L Howard, D R Chettle
The safety of using Gd in MRI contrast agents has recently been questioned, due to recent evidence of the retention of Gd in individuals with healthy renal function. Bone has proven to be a storage site for Gd, as unusually high concentrations have been measured in femoral heads of patients undergoing hip replacement surgery, as well as in autopsy samples. All previous measurements of Gd in bone have been invasive and required the bone to be removed from the body. X-ray fluorescence (XRF) offers a non-invasive and non-destructive method for carrying out in vivo measurements of Gd in humans...
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27885402/-retention-of-contrast-media-in-the-history-of-radiology-sequelae%C3%A2-of%C3%A2-the-former-use-of-thorotrast-and-new-challenges
#17
G van Kaick, S Delorme
Detection of gadolinium deposits in patients who have repeatedly been administered intravenous gadolinium chelates have given rise to concern regarding the long-term safety of magnetic resonance imaging (MRI) contrast media. Nevertheless, negative long-term clinical effects have not yet been observed. In some publications parallels have been drawn to the sequelae of thorotrast that was formerly used for arterial angiography. In this article the history of thorotrast use is briefly described and in particular why, despite warnings, this substance was used frequently and worldwide...
December 2016: Der Radiologe
https://www.readbyqxmd.com/read/27837539/gadolinium-loaded-polychelating-polymer-containing-tumor-targeted-liposomes
#18
Suna Erdogan, Vladimir P Torchilin
Magnetic resonance (MR) is one of the most widely used imaging modalities in contemporary medicine to obtain images of pathological areas. Still, there is a big effort to facilitate the accumulation of contrast in the required zone and further increase a local spatial concentration of a contrast agent for better imaging. Certain particulate carriers able to carry multiple contrast moieties can be used for an efficient delivery of contrast agents to areas of interest and enhancing a signal from these areas. Among those carriers, liposomes draw special attention because of their easily controlled properties and good pharmacological characteristics...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27834725/do-gadolinium-based-contrast-agents-affect-18-f-fdg-pet-ct-uptake-in-the-dentate-nucleus-and-the-globus-pallidus-a-pilot-study
#19
Kyle Bauer, Alaina Lathrum, Osama Raslan, Patrick V Kelly, Yihua Zhou, Debra Hewing, Crystal Botkin, James A Turner, Medhat Osman
Gadolinium is toxic and to avoid its deposition in tissues, it must be chemically bonded with nonmetal ions to facilitate its excretion by the kidneys. High signal intensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted MR images has been both morphologically and pathologically linked to gadolinium-based contrast agent (GBCA) retention in the brain. The purpose of this study was to determine whether repeated administrations of GBCA would affect the uptake of (18)F-FDG in the DN and GP on PET/CT...
March 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27693607/gadolinium-toxicity-and-treatment
#20
REVIEW
Joana Ramalho, Miguel Ramalho, Michael Jay, Lauren M Burke, Richard C Semelka
Gadolinium based contrast agents (GBCAs) play an important role in the diagnostic evaluation of many patients. The safety of these agents has been once again questioned after gadolinium deposits were observed and measured in brain and bone of patients with normal renal function. This retention of gadolinium in the human body has been termed "gadolinium storage condition". The long-term and cumulative effects of retained gadolinium in the brain and elsewhere are not as yet understood. Recently, patients who report that they suffer from chronic symptoms secondary to gadolinium exposure and retention created gadolinium-toxicity on-line support groups...
December 2016: Magnetic Resonance Imaging
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