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https://www.readbyqxmd.com/read/29235943/-trapped-in-an-empty-waiting-room-the-existential-human-core-of-loneliness-in-old-age-a-meta-synthesis
#1
Gabriele Kitzmüller, Anne Clancy, Mojtaba Vaismoradi, Charlotte Wegener, Terese Bondas
Loneliness in old age has a negative influence on quality of life, health, and survival. To understand the phenomenon of loneliness in old age, the voices of lonely older adults should be heard. Therefore, the purpose of this meta-synthesis was to synthesize scientific studies of older adults' experiences of loneliness. Eleven qualitative articles that met the inclusion criteria were analyzed and synthesized according to Noblit and Hare's meta-ethnographic approach. The analysis revealed the overriding meaning of the existential human core of loneliness in old age expressed through the metaphor "trapped in an empty waiting room...
January 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29232823/improving-cerebral-blood-flow-after-arterial-recanalization-a-novel-therapeutic-strategy-in-stroke
#2
REVIEW
Mohamad El Amki, Susanne Wegener
Ischemic stroke is caused by a disruption in blood supply to a region of the brain. It induces dysfunction of brain cells and networks, resulting in sudden neurological deficits. The cause of stroke is vascular, but the consequences are neurological. Decades of research have focused on finding new strategies to reduce the neural damage after cerebral ischemia. However, despite the incredibly huge investment, all strategies targeting neuroprotection have failed to demonstrate clinical efficacy. Today, treatment for stroke consists of dealing with the cause, attempting to remove the occluding blood clot and recanalize the vessel...
December 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29228529/efficacy-of-bronchial-washing-and-brushing-cytology-in-the-diagnosis-of-non-neoplastic-lung-diseases
#3
Rahil Giti, Massood Hosseinzadeh
Flexible fiberoptic bronchoscopy is often the initial technique for diagnosis of lung and bronchial tumors. Many studies have shown the high accuracy rate of bronchial washing and brushing cytology in the evaluation of neoplastic and non-neoplastic bronchopulmonary lesions. The aim of this study is to emphasize the value of the bronchial cytologic findings for diagnosis of non-neoplastic bronchopulmonary lesions. In a cross-sectional study, we retrieved all cases with bronchial washing and brushing cytology from 21 Mach 2014 to 21 December 2015...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29228215/mitochondria-are-critical-for-bdnf-mediated-synaptic-and-vascular-plasticity-of-hippocampus-following-repeated-electroconvulsive-seizures
#4
Fenghua Chen, Maryam Ardalan, Betina Elfving, Gregers Wegener, Torsten M Madsen, Jens R Nyengaard
Background: Electroconvulsive therapy (ECT) is a fast acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections and synaptic remodeling is thought to play a critical role for the clinical efficacy obtained from a rapid antidepressant response. Here, we investigated the relationship between, synaptic changes and concomitant non-neuronal changes in microvasculature and mitochondria, and it relationship to Brain-derived neurotrophic factor (BDNF) level changes after repeated electroconvulsive seizures (ECS), an animal model of ECT...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29212742/getting-the-first-grant
#5
REVIEW
Susanne Wegener, Mira Katan
No abstract text is available yet for this article.
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29211437/a-high-performance-transition-metal-phosphide-alloy-catalyst-for-oxygen-evolution-reaction
#6
Kewei Liu, Changlin Zhang, Yuandong Sun, Guanghui Zhang, Xiaochen Shen, Feng Zou, Haichang Zhang, Zhenwei Wu, Evan C Wegener, Clinton J Taubert, Jeffrey T Miller, Zhenmeng Peng, Yu Zhu
Oxygen evolution reaction (OER) is a pivotal process in many energy conversion and storage techniques, such as water splitting, regenerative fuel cells, and rechargeable metal-air batteries. The synthesis of stable, efficient, non-noble metal-based electrocatalysts for OER has been a long-standing challenge. In this work, a facile and scalable method to synthesize hollow and conductive iron-cobalt phosphide (Fe-Co-P) alloy nanostructures using a Fe-Co metal organic complex as a precursor is described. The Fe-Co-P alloy exhibits excellent OER activity with a specific current density of 10 mA/cm2 being achieved at an overpotential as low as 252 mV...
December 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/29193168/energy-response-corrections-for-profile-measurements-using-a-combination-of-different-detector-types
#7
Sonja Wegener, Otto A Sauer
PURPOSE: Different detector properties will heavily affect the results of off-axis measurements outside of radiation fields, where a different energy spectrum is encountered. While a diode detector would show a high spatial resolution, it contains high atomic number elements, which lead to perturbations and energy dependent response. An ionization chamber, on the other hand, has a much smaller energy-dependence, but shows dose averaging over its larger active volume. We suggest a way to obtain spatial energy-response corrections of a detector independent of its volume effect for profiles of arbitrary fields by using a combination of two detectors...
November 29, 2017: Medical Physics
https://www.readbyqxmd.com/read/29173695/scientific-people-named-in-the-classification-of-vasculitis
#8
Gokhan Sargin, Taskin Senturk
The first International Chapel Hill Consensus Conference was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second Chapel Hill Consensus Conference 2012, which were not included in the Chapel Hill Consensus Conference 1994. The new nomenclature was introduced instead of being referred to by many names such as Churg-Strauss and Wegener"s. New categories such as Behçet"s and Cogan etc...
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29171723/a-sterically-constrained-tricyclic-pc3-phosphine-coordination-behaviour-and-insertion-of-chalcogen-atoms-into-p-c-bonds
#9
Werner Uhl, Anne Hentschel, Alexander Brand, Philipp Wegener
The tricyclic phosphine 4 has a rigid molecular backbone, the P atoms exclusively bound to sp2-C atoms, a very large Tolman angle and buried volume. It is an interesting new ligand in coordination chemistry (Au, Pd complexes) and shows unusu-al insertion reactions into endocyclic P-C bonds facilitated by its inherent molecular strain.
November 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29170236/three-dimensional-mechanical-metamaterials-with-a-twist
#10
Tobias Frenzel, Muamer Kadic, Martin Wegener
Rationally designed artificial materials enable mechanical properties that are inaccessible with ordinary materials. Pushing on an ordinary linearly elastic bar can cause it to be deformed in many ways. However, a twist, the counterpart of optical activity in the static case, is strictly zero. The unavailability of this degree of freedom hinders applications in terms of mode conversion and the realization of advanced mechanical designs using coordinate transformations. Here, we aim at realizing microstructured three-dimensional elastic chiral mechanical metamaterials that overcome this limitation...
November 24, 2017: Science
https://www.readbyqxmd.com/read/29167992/slow-correction-of-severe-spastic-hyperlordosis-in-an-adult-by-means-of-magnetically-expandable-rods
#11
Christof Birkenmaier, Melvin D'Anastasi, Bernd Wegener, Carolin Melcher
BACKGROUND: We describe a case of severe and progressive lumbar hyperlordosis (160°) in a 28-year-old female university student with cerebral palsy. Her main complaints were abdominal wall pain and increasing inability to sit in her custom wheelchair. METHOD: When deciding on our opinion about the most promising treatment strategy, we contemplated slow continued correction by means of percutaneously expandable magnetic rods (MAGEC) after the index surgery as a key component of a satisfactory correction in this severe and rigid curve...
November 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29167034/body-awareness-training-in-the-treatment-of-wearing-off-related-anxiety-in-patients-with-parkinson-s-disease-results-from-a-pilot-randomized-controlled-trial
#12
Ires Ghielen, Erwin E H van Wegen, Sonja Rutten, Cees J T de Goede, Marieke Houniet-de Gier, Emma H Collette, Ingrid A L Burgers-Bots, Jos W R Twisk, Gert Kwakkel, Kees Vermunt, Bep van Vliet, Henk W Berendse, Odile A van den Heuvel
BACKGROUND: In Parkinson's disease (PD) patients, fluctuations in symptoms commonly occur after many years of dopamine replacement therapy. The so-called wearing-off phenomenon exists of both motor and non-motor symptoms, such as rigidity and anxiety. Current treatment options are limited and an integrated approach is needed to address the complex interactions between motor and non-motor symptoms. Since wearing-off is eventually inevitable, treatment needs to focus on coping, acceptance and self-efficacy...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29154300/fracture-generation-in-human-vertebrae-under-compression-loading-the-influence-of-pedicle-preservation-and-bone-mineral-density-on-in-vitro-fracture-behavior
#13
Michael Kraxenberger, Christian Schröder, Tobias Geith, Andreas Büttner, Christoph von SchulzePeelengahr, Christof Birkenmaier, Peter Muller, Volkmar Jansson, Bernd Wegener
BACKGROUND: Fractured vertebral bodies are a common and wide spread health issue. OBJECTIVE: The purpose of this study was to develop a standardized method to experimentally generate compression fractures in vertebral bodies. The influence of the pedicles has been investigated with regards to the fracture behavior. The correlation between bone mineral density (BMD), the cause of fractures and the fracture behavior was investigated. METHODS: Twenty-one fresh frozen human lumbar spines were examined for bone mineral density (BMD) by means of quantitative computed tomography (qCT)...
November 10, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29151405/acta-neuropsychiatrica-and-social-media
#14
Gregers Wegener
No abstract text is available yet for this article.
December 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29149199/epidemiology-and-clinical-profile-of-pathogens-responsible-for-the-hospitalization-of-children-in-sousse-area-tunisia
#15
Ines Brini, Aida Guerrero, Naila Hannachi, Jihene Bouguila, Dorothea Orth-Höller, Amira Bouhlel, Lamia Boughamoura, Benjamin Hetzer, Wegene Borena, Britta Schiela, Dorothee Von Laer, Jalel Boukadida, Heribert Stoiber
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29148801/neuropeptidomics-of-the-bed-bug-cimex-lectularius
#16
Reinhard Predel, Susanne Neupert, Christian Derst, Klaus Reinhardt, Christian Wegener
The bed bug Cimex lectularius is a globally distributed human ectoparasite with fascinating biology. It has recently acquired resistance against a broad range of insecticides, causing a worldwide increase in bed bug infestations. The recent annotation of the bed bug genome revealed a full complement of neuropeptide and neuropeptide receptor genes in this species. With regard to the biology of C. lectularius, neuropeptide signalling is especially interesting since it regulates feeding, diuresis, digestion as well as reproduction, and also provides potential new targets for chemical control...
November 17, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29139157/seronegative-granulomatosis-with-polyangiitis-presenting-with-multiple-cranial-nerve-palsies
#17
Eunhye Lee, Jynkyun Park, Seung Hong Choi, Sung-Hye Park
Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), is a rare systemic disease characterized by necrotizing granulomas and vasculitis that usually presents in the respiratory tract and renal system. Here, we report a case of anti-neutrophil cytoplasmic antibody (ANCA)-negative GPA with diagnostic difficulties. Neurologic involvement in GPA is not uncommon, with up to 50% of patients manifesting with neurologic defects; however, it is usually a late event. This patient was a 50-year-old man whose first manifestation was multiple neurologic defects without respiratory or renal symptoms...
November 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29136373/photocontrol-of-antibacterial-activity-shifting-from-uv-to-red-light-activation
#18
Michael Wegener, Mickel J Hansen, Arnold J M Driessen, Wiktor Szymanski, Ben L Feringa
The field of photopharmacology aims to introduce smart drugs that, through the incorporation of molecular photoswitches, allow for the remote spatial and temporal control of bioactivity by light. This concept could be particularly beneficial in the treatment of bacterial infections, by reducing the systemic and environmental side-effects of antibiotics. A major concern in the realization of such light-responsive drugs is the wavelength of the light that is applied. Studies on the photocontrol of biologically active agents mostly rely on UV light, which is cytotoxic and poorly suited for tissue penetration...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29131598/speciation-of-cucl-and-cucl2-thiol-amine-solutions-and-characterization-of-resulting-films-implications-for-semiconductor-device-fabrication
#19
Priya Murria, Caleb K Miskin, Robert Boyne, Laurance T Cain, Ravikiran Yerabolu, Ruihong Zhang, Evan C Wegener, Jeffrey T Miller, Hilkka I Kenttämaa, Rakesh Agrawal
Thiol-amine mixtures are an attractive medium for the solution processing of semiconducting thin films because of their remarkable ability to dissolve a variety of metals, metal chalcogenides, metal salts, and chalcogens. However, very little is known about their dissolution chemistry. Electrospray ionization high-resolution tandem mass spectrometry and X-ray absorption spectroscopy were employed to identify the species formed upon dissolution of CuCl and CuCl2 in 1-propanethiol and n-butylamine. Copper was found to be present exclusively in the 1+ oxidation state for both solutions...
November 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29124859/sympatric-kelp-species-share-a-large-portion-of-their-surface-bacterial-communities
#20
Matthew A Lemay, Patrick T Martone, Patrick Keeling, Jenn M Burt, Kira A Krumhansl, Rhea D Sanders, Laura Wegener Parfrey
Kelp forest ecosystems are biodiversity hotspots, providing habitat for dense assemblages of marine organisms and nutrients for marine and terrestrial food webs. The surfaces of kelps support diverse microbial communities that facilitate the transfer of carbon from algal primary production to higher trophic levels. We quantified the diversity of bacteria on the surfaces of eight sympatric kelp species from four sites in British Columbia. Kelp-associated bacterial communities are significantly different from their environment, even though 86% of their bacterial taxa are shared with seawater and 97% are shared with rocky substrate...
November 10, 2017: Environmental Microbiology
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