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Katrine Wegener Tams, Martin Jensen Søe, Inga Merkyte, Frederik Valeur Seersholm, Peter Steen Henriksen, Susanne Klingenberg, Eske Willerslev, Kurt H Kjær, Anders Johannes Hansen, Christian Moliin Outzen Kapel
In this study, we screen archaeological soil samples by microscopy and analyse the samples by next generation sequencing to obtain results with parasites at species level and untargeted findings of plant and animal DNA. Three separate sediment layers of an ancient man-made pond in Hoby, Denmark, ranging from 100 BC to 200 AD, were analysed by microscopy for presence of intestinal worm eggs and DNA analysis were performed to identify intestinal worms and dietary components. Ancient DNA of parasites, domestic animals and edible plants revealed a change in use of the pond over time reflecting the household practice in the adjacent Iron Age settlement...
2018: PloS One
Kate L Wegener, Amy E McGrath, Nicholas E Dixon, Aaron J Oakley, Denis B Scanlon, Andrew D Abell, John Bruning
The human sliding clamp (PCNA) controls access to DNA for many proteins involved in DNA replication and repair. Proteins are recruited to the PCNA surface by means of a short, conserved peptide motif known as the PCNA-interacting protein box (PIP-box). Inhibitors of these essential protein-protein interactions may be useful as cancer therapeutics by disrupting DNA replication and repair in these highly proliferative cells. PIP-box peptide mimetics have been identified as a potentially rapid route to potent PCNA inhibitors...
June 19, 2018: Chemistry: a European Journal
Kateřina Jirků Pomajbíková, Milan Jirků, Jana Levá, Kateřina Sobotková, Evan Morien, Laura Wegener Parfrey
The tapeworm Hymenolepis diminuta is a model for the impact of helminth colonization on the mammalian immune system and a candidate therapeutic agent for immune mediated inflammatory diseases (IMIDs). In mice, H. diminuta protects against models of inflammatory colitis by inducing a strong type 2 immune response that is activated to expel the immature worm. Rats are the definitive host of H. diminuta, and are colonized stably and over long time periods without harming the host. Rats mount a mild type 2 immune response to H...
June 18, 2018: Parasitology
Abdulgafoor M Bachani, Nino Paichadze, Jacob A Bentley, Nazarius Mbona Tumwesigye, David Bishai, Lynn Atuyambe, Stephen Wegener, David Guwatudde, Olive C Kobusingye, Adnan A Hyder
Problem: The burden of trauma and injuries in Uganda is substantial and growing. Two important gaps that need addressing are the shortage of trained people and a lack of national data on noncommunicable diseases and their risk factors in Uganda. Approach: We developed and implemented a new track within an existing master of public health programme, aimed at developing graduate-level capacity and promoting research on key national priorities for trauma and injuries...
June 1, 2018: Bulletin of the World Health Organization
Lasse Malmqvist, Lulu Bursztyn, Fiona Costello, Kathleen Digre, J Alexander Fraser, Clare Fraser, Bradley Katz, Mitchell Lawlor, Axel Petzold, Patrick Sibony, Judith Warner, Marianne Wegener, Sui Wong, Steffen Hamann
No abstract text is available yet for this article.
June 12, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Jiakai Li, Chuangui Li, Jiaojiao Li
The aim of the present study was to investigate the computed tomography (CT) manifestations of Wegener granulomatosis (WG) in the chest and potential reasons for misdiagnosis. Conventional CT scans and clinical data of 45 patients with WG were retrospectively analyzed. Patients typically presented with multiple system involvement, primarily in the upper and lower respiratory tract. The incidence of thoracic involvement was 75.56% (34/45). Radiographic features were varied between cases in the present study, with the most common features being numerous cavitary nodules and masses in the lungs...
July 2018: Experimental and Therapeutic Medicine
Jessica Wegener, Marilyne Petitclerc
Dietetic educators and practicum coordinators (PC) play critical roles in preparing students for practice. Dietitians have made significant progress in the development of educational curricula, competencies, and other resources to support knowledge and skill attainment in public health. There are identified gaps in the literature concerning practical training in sustainable food systems and public health, creating barriers in knowledge exchange and improvements in practicum programs in Canada. This paper discusses the potential opportunities and challenges associated with the number of placements for practical training in public health based on interviews with PCs in Ontario...
June 12, 2018: Canadian Journal of Dietetic Practice and Research
Lasse Malmqvist, Patrick A Sibony, Clare L Fraser, Marianne Wegener, Steffen Heegaard, Marie Skougaard, Steffen Hamann
No abstract text is available yet for this article.
June 8, 2018: Ophthalmology
Diana Crisan, Lars Alexander Schneider, Sabine Kastler, Karin Scharffetter-Kochanek, Maria Crisan, Johannes Alexander Veit
Die Hauptursachen erworbener Ohrmuscheldefekte sind chirurgische Behandlung von Hauttumoren und Traumata. Wegen der komplexen Anatomie des Außenohrs ist die chirurgische Rekonstruktion von Defekten in dieser Region für Operateure herausfordernd, insbesondere wenn die mittlere Helix und Anthelix von größeren Weichteil- und Knorpelverlusten betroffen sind. Wir stellen hier die wichtigsten Techniken zur Rekonstruktion großer Defekte der mittleren Helix und Anthelix sowie die Vor- und Nachteile jedes chirurgischen Verfahrens vor...
June 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Amanda J Sales, Manoela V Fogaça, Ariandra G Sartim, Vitor S Pereira, Gregers Wegener, Francisco S Guimarães, Sâmia R L Joca
Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, is a promising compound since it shows large-spectrum therapeutic potential in preclinical models and humans. However, its antidepressant properties have not been completely investigated. Therefore, the aims of this study were to investigate in male rodents (i) whether CBD could induce rapid and sustained antidepressant-like effects after a single administration and (ii) whether such effects could be related to changes in synaptic proteins/function...
June 4, 2018: Molecular Neurobiology
Matthias Pursch, Antje Wegener, Stephan Buckenmaier
A new methodology is presented for two-dimensional liquid chromatography (2D-LC) separations of polymers. Active solvent modulation (ASM) was evaluated in its effectiveness to enhance solvent compatibility for both separation dimensions. As an example the determination of target compounds in epoxy resins was used. Ultra-high pressure size-exclusion chromatography was applied in the first dimension using THF as the solvent. The second dimension separation was operated in reversed-phase mode using an acetonitrile/water gradient...
May 28, 2018: Journal of Chromatography. A
Daniel Bauer, Jakob Wegener, Kaspar Bienefeld
Hygienic behavior, i.e. the removal of diseased or damaged brood by worker honey bees (Apis mellifera), is seen as one of the principal behavioral elements of this species' social immunity. Identification of the stimuli that trigger it would be helpful in searching for biochemical and molecular markers of this important breeding trait. While many studies at the genomic, transcriptomic, and behavioral level have pointed to the implication of chemical cues, we here hypothesized that thermal cues are alternatively/additionally involved...
May 2018: Journal of Thermal Biology
Line Kessel, Steffen Hamann, Marianne Wegener, Jessica Tong, Clare L Fraser
Cavitations in the inner nuclear layer associated with severe optic atrophy and loss of retinal ganglion cells have clinically been termed microcystic macular oedema (MME). We describe a case series of MME in patients of all ages but predominantly younger patients with a wide range of optic atrophies ranging from acute onset optic disc drusen associated ischemic optic neuropathy to slowly progressive disease as glaucoma. There were no physical distinctions between MME in different causes of optic atrophy suggesting a common causative mechanism...
May 25, 2018: Clinical & Experimental Ophthalmology
Judith Vloothuis, Julya de Bruin, Marijn Mulder, Rinske Nijland, Gert Kwakkel, Erwin E H van Wegen
No abstract text is available yet for this article.
May 24, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
Sarah B Zandvliet, Carel G M Meskers, Gert Kwakkel, Erwin E H van Wegen
Transcranial direct current stimulation (tDCS) may serve as an adjunct approach in stroke rehabilitation. The cerebellum could be a target during standing balance training due to its role in motor adaptation. We tested whether cerebellar tDCS can lead to short-term effects on standing balance performance in patients with chronic stroke. Fifteen patients with a chronic stroke were stimulated with anodal stimulation on the contra-lesional cerebellar hemisphere, ipsi-lesional cerebellar hemisphere, or sham stimulation, for 20 min with 1...
May 24, 2018: Cerebellum
Yasser Emad, Yasser Ragab, Johannes J Rasker
Antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides include granulomatosis with polyangiitis (GPA, previously called Wegener's), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss). In this report we used mycophenolate mofetil (MMF) and steroids to induce and maintain remission in two newly diagnosed cases with c-ANCA associated GPA. The two patients' maintained remission with no disease relapses during one year follow-up...
May 16, 2018: Reumatología Clinica
Alexa Caldwell, Jan Niklas Morick, Anne-Marie Jentsch, Annette Wegener, Dragan Pavlovic, Nadia Al-Banna, Christian Lehmann
BACKGROUND: Sepsis involves dysfunctional glucose metabolism. Among patients with sepsis, hyperglycemia is frequent and insulin administration has been evaluated for glycemic control to improve patient outcomes. Only few studies have examined the hyperglycemic microcirculation and the impact of insulin on the microvasculature in sepsis. OBJECTIVE: To study the functional capillary density (FCD) and leukocyte activation within the intestinal microcirculation in endotoxin-induced experimental sepsis...
May 17, 2018: Microvascular Research
Rafael Laso-Pérez, Viola Krukenberg, Florin Musat, Gunter Wegener
Traditionally, the description of microorganisms starts with their isolation from an environmental sample. Many environmentally relevant anaerobic microorganisms grow very slowly, and often they rely on syntrophic interactions with other microorganisms. This impedes their isolation and characterization by classic microbiological techniques. We developed and applied an approach for the successive enrichment of syntrophic hydrocarbon-degrading microorganisms from environmental samples. We collected samples from microbial mat-covered hydrothermally heated hydrocarbon-rich sediments of the Guaymas Basin and mixed them with synthetic mineral medium to obtain sediment slurries...
June 2018: Nature Protocols
Luca Liberale, Federico Carbone, Fabrizio Montecucco, Cathérine Gebhard, Thomas F Lüscher, Susanne Wegener, Giovanni G Camici
Stroke prevalence is expected to increase in the next decades due to the aging of the Western population. Ischemic stroke (IS) shows an age- and sex-dependent distribution in which men represent the most affected population within 65 years of age, being passed by post-menopausal women in older age groups. Furthermore, a sexual dimorphism concerning risk factors, presentation and treatment of IS has been widely recognized. In order to address these phenomena, a number of issue have been raised involving both socio-economical and biological factors...
May 12, 2018: Frontiers in Neuroendocrinology
Carolin Melcher, Bernd Wegener, Volkmar Jansson, Wolf Mutschler, Karl-Georg Kanz, Christof Birkenmaier
BACKGROUND: Low back pain is a common problem for primary care providers, outpatient clinics and A&E departments. The predominant symptoms are those of so-called "unspecific back pain", but serious pathologies can be concealed by the clinical signs. Especially less experienced colleagues have problems in treating these patients, as - despite the multitude of recommendations and guidelines - there is no generally accepted algorithm. METHODS: After a literature search (Medline/Cochrane), 158 articles were selected from 15,000 papers and classified according to their level of evidence...
May 14, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
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