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Antioxidant cancer cervical

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https://www.readbyqxmd.com/read/28208804/hazelnut-corylus-avellana-l-shells-extract-phenolic-composition-antioxidant-effect-and-cytotoxic-activity-on-human-cancer-cell-lines
#1
Tiziana Esposito, Francesca Sansone, Silvia Franceschelli, Pasquale Del Gaudio, Patrizia Picerno, Rita Patrizia Aquino, Teresa Mencherini
Hazelnut shells, a by-product of the kernel industry processing, are reported to contain high amount of polyphenols. However, studies on the chemical composition and potential effects on human health are lacking. A methanol hazelnut shells extract was prepared and dried. Our investigation allowed the isolation and characterization of different classes of phenolic compounds, including neolignans, and a diarylheptanoid, which contribute to a high total polyphenol content (193.8 ± 3.6 mg of gallic acid equivalents (GAE)/g of extract)...
February 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28184999/rosiglitazone-enhances-radiosensitivity-by-inhibiting-repair-of-dna-damage-in-cervical-cancer-cells
#2
Zhengzhe An, Jae-Ran Yu, Woo-Yoon Park
Radiation therapy (RT) is one of the main treatment modalities for cervical cancer. Rosiglitazone (ROSI) has been reported to have antiproliferative effects against various types of cancer cells and also to induce antioxidant enzymes that can scavenge reactive oxygen species (ROS) and thereby modify radiosensitivity. Here, we explored the effect of ROSI on radiosensitivity and the underlying mechanisms in cervical cancer cells. Three cervical cancer cell lines (ME-180, HeLa, and SiHa) were used. The cells were pretreated with ROSI and then irradiated...
February 9, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28160857/eulophia-macrobulbon-an-orchid-with-significant-anti-inflammatory-and-antioxidant-effect-and-anticancerogenic-potential-exerted-by-its-root-extract
#3
Roswitha Schuster, Laura Zeindl, Wolfgang Holzer, Nattakanwadee Khumpirapang, Siriporn Okonogi, Helmut Viernstein, Monika Mueller
BACKGROUND: The Orchidaceae family is one of the largest families of flowering plants. Orchids are widely used for the traditional herbal medicine, acting as aphrodisiac, antisepic, antimicrobial, anti-cancer agent, etc. PURPOSE: This study was designed to elucidate the anti-inflammatory, antioxidant and cytotoxic potential of a 50% ethanolic extract of Eulophia macrobulbon roots (EME) in vitro, an orchid growing in Southern Asia. Furthermore, the main active compounds were isolated, and the bioactivity of the single constituents was determined...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28105861/a-novel-benzimidazole-and-other-constituents-with-antiproliferative-and-antioxidant-properties-from-thymelaea-microphylla-coss-et-dur
#4
Labib Noman, Feyza Oke-Altuntas, Amar Zellagui, Ayse Sahin Yaglioglu, Ibrahim Demirtas, Susana M Cardoso, Salah Akkal, Noureddine Gherraf, Salah Rhouati
A new compound (microphybenzimidazole, 7) along with the six known compounds matairesinol (1), prestegane B (2), umbelliferone (3), daphnoretin (4), microphynolide A (5) and microphynolide B (6) were isolated from Thymelaea microphylla. The structures of the pure compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR, and HPLC-TOF/MS. Compounds 2 and 4, as well as three fractions (F6, F6-C5, and F6-W42) obtained from a 50% (v:v) CH2Cl2:MeOH extract exhibited a selective activity against rat brain glioma cells (C6)...
January 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28093329/antioxidant-antitumor-and-immunostimulatory-activities-of-the-polypeptide-from-pleurotus-eryngii-mycelium
#5
Yanan Sun, Xinlei Hu, Wenxiang Li
The objective of this study was to investigate the antioxidant, antitumor and immunological activities of the polypeptide from Pleurotus eryngii mycelium (PEMP). The ability of the polypeptide to stimulate Ana-1 macrophages to englobe neutral red, secrete NO, H2O2, TNF-α, and IL-6, increase TLR2 and TLR4 expression levels and Ana-1 cell survival rate were investigated to study its immunocompetence. Its antitumor activities were studied by examining the survival of cervical, breast, and stomach cancer cells...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28053569/synthesis-of-n-mannich-bases-of-berberine-linking-piperazine-moieties-revealing-anticancer-and-antioxidant-effects
#6
Bhupendra Mistry, Rahul V Patel, Young-Soo Keum, Doo Hwan Kim
A new Mannich base series of piperazine linked berberine analogues was furnished in this study to screen the antioxidant and anticancer potential of the resultant analogues. Alkoxy group at a C-9 position of berberine was converted to hydroxyl functionality to enhance the ability of final scaffolds binding to the target of drug action mainly through hydrophobic effect, conjugation effect, whereas Mannich base functionality was introduced on the C-12 position of berberine. Scaffolds were investigated for their free radical scavenging antioxidant potential in FRAP and DPPH assay, whereas tested to check their Fe(+3) reducing power in ABTS assay...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28039786/dna-interaction-antimicrobial-antioxidant-and-anticancer-studies-on-cu-ii-complexes-of-luotonin-a
#7
M P Kesavan, G G Vinoth Kumar, J Dhaveethu Raja, K Anitha, S Karthikeyan, J Rajesh
Luotonin A (L), a novel natural cytotoxic and anti-inflammatory alkaloid, chelated with copper(II) to improve its cytotoxic effect against the cancer cells. The complexes [Cu(L)H2OCl]Cl (1) and [Cu(L)2]Cl2 (2) are prepared by using copper(II) chloride and L with ligand/metal molar ratio of 1:1 and 2:1 respectively. A solution of complexes 1 &2 are characterized by physical spectroscopic methods using Ultraviolet-visible (UV-Vis) spectrophotometer, Fourier Transform-Infra red (FT-IR) spectroscopy, Electron Para magnetic Resonance Spectroscopy (EPR) and by electrochemical methods...
December 22, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28004224/antioxidant-and-antiproliferative-effects-of-different-solvent-fractions-from-terminalia-belerica-roxb-fruit-on-various-cancer-cells
#8
Tapasree Basu, Sourav Panja, Nikhil Baban Ghate, Dipankar Chaudhuri, Nripendranath Mandal
Terminalia belerica Roxb. fruits have been previously reported against diabetes, ulcer, microbial problems and hepatotoxicity. The present study was aimed to investigate antioxidant and anticancer potential of sequentially fractionated hexane (TBHE), chloroform (TBCE), ethyl acetate (TBEE), butanol (TBBE) and water (TBWE) extracts from the 70% methanolic extract of T. belerica fruits. TBCE, TBEE, TBBE and TBWE showed excellent ROS (reactive oxygen species) and RNS (reactive nitrogen species) scavenging activities which was investigated using 11 different assays for various free radicals...
December 21, 2016: Cytotechnology
https://www.readbyqxmd.com/read/28001084/resveratrol-as-an-anticancer-agent-a-review
#9
Abdur Rauf, Muhammad Imran, Masood Sadiq Butt, Muhammad Nadeem, Dennis G Peters, Mohammad S Mubarak
Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera L.) are the archetypal paradigms of fruits used not only for nutritional purposes but also for exclusive therapeutics. Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemopreventive and therapeutic effects against various ailments. Resveratrol's role in reducing different human cancers, including breast, cervical, uterine, blood, kidney, liver, eye, bladder, thyroid, esophageal, prostate, brain, lung, skin, gastric, colon, head and neck, bone, ovarian, and cervical, has been reviewed...
December 21, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27973724/investigations-on-antioxidant-antiproliferative-and-cox-2-inhibitory-potential-of-alkaloids-from-anthocephalus-cadamba-roxb-miq-leaves
#10
Madhu Chandel, Manish Kumar, Upendra Sharma, Bikram Singh, Satwinderjeet Kaur
In the present study, an ayurvedic medicinal plant, Anthocephalus cadamba (Roxb.) Miq. commonly known as "Kadamb" was explored for its potential against oxidative stress and cancer. The fractions namely AC-4 and ACALK (alkaloid rich fraction) were isolated from Anthocephalus cadamba leaves by employing two different isolation methods and evaluated for their in vitro antioxidant and antiproliferative activity. The isolated molecule, AC-4 was characterized tentatively as dihydrocadambine by using various spectroscopic techniques such as ESI-QTOF-MS, (1) H-NMR, (13) C-NMR, DEPT, COSY, HMQC and HMBC...
December 14, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27928516/antioxidant-and-antiproliferative-activities-of-purslane-seed-oil
#11
Gai Guo, Li Yue, Shaoli Fan, Siqun Jing, Liang-Jun Yan
The aim of this study was to evaluate the antioxidant and antiproliferative activities of PSO in vitro and its application in horse oil storage. We determined the reducing power of PSO and its scavenging effects on hydroxyl (•OH) and 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH•) and tested its stabilizing effects on horse oil storage. The results showed that PSO had remarkable, dose-dependent antioxidant activities, and it effectively prevented horse oil lipid oxidation. We treated cervical cancer HeLa cells, esophageal cancer Eca-109 cells and breast cancer MCF-7 cells with PSO using non-neoplastic monkey kidney Vero cells as controls...
June 2016: Journal of Hypertension: Open Access
https://www.readbyqxmd.com/read/27904404/phenolic-composition-antioxidant-capacity-and-in-vitro-cytotoxicity-assessment-of-fruit-wines
#12
Ana Ljevar, Natka Ćurko, Marina Tomašević, Kristina Radošević, Višnja Gaurina Srček, Karin Kovačević Ganić
Fruit wines contain a wide range of phenolic compounds with biological effects, but their composition and potential benefits to human health have been studied to the much lesser extent compared to grape wines. The aim of this research is to study the phenolic profile of different types of fruit wines and to evaluate their antioxidant and biological potential. Commercially available fruit wines from blackberry, cherry, raspberry, blackcurrant, strawberry and apple produced in Croatia were analyzed. To the best of our knowledge, this study represents the first comprehensive screening of Croatian fruit wines...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27902484/depletion-of-mitochondrial-reactive-oxygen-species-downregulates-epithelial-to-mesenchymal-transition-in-cervical-cancer-cells
#13
Galina Shagieva, Lidiya Domnina, Olga Makarevich, Boris Chernyak, Vladimir Skulachev, Vera Dugina
In the course of cancer progression, epithelial cells often acquire morphological and functional characteristics of mesenchymal cells, a process known as epithelial-to-mesenchymal transition (EMT). EMT provides epithelial cells with migratory, invasive, and stem cell capabilities. Reactive oxygen species produced by mitochondria (mtROS) could be of special importance for pro-tumorigenic signaling and EMT.In our study, we used mitochondria-targeted antioxidant SkQ1 to lower the mtROS level and analyze their role in the regulation of the actin cytoskeleton, adhesion junctions, and signaling pathways critical for tumorigenesis of cervical carcinomas...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27889456/synthesis-of-new-morpholine-connected-pyrazolidine-derivatives-and-their-antimicrobial-antioxidant-and-cytotoxic-activities
#14
Radhakrishnan Surendra Kumar, Meera Moydeen, Salem S Al-Deyab, Aseer Manilal, Akbar Idhayadhulla
A simple and convenient one-pot four-component synthesis of morpholine-connected pyrazolidine derivatives 2a-f and 4a-f was developed using direct metal-free catalysis, with the identities of the synthesized compounds confirmed by IR, NMR ((1)H and (13)C), mass spectrometry, and elemental analysis. The prepared compounds were inspected for antimicrobial, antioxidant, and cytotoxic activities. Antimicrobial and antifungal activities against five bacterial and four fungal pathogens, respectively, were investigated using the disc diffusion technique...
January 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27881109/anti-tumor-effects-of-abnormal-savda-munziq-on-the-transplanted-cervical-cancer-u27-mouse-model
#15
Zuhragul Omarniyaz, Yang Yu, Tao Yang, Lianlian Shan, Weiwei Miao, Renaguli Reyimu, Halmurat Upur, Ainiwaer Aikemu
BACKGROUND: Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. it was showed that total flavonoids of ASMq could inhibit the proliferation and enhance the antioxidant ability of human cervix cancer HeLa cell. This study attempts to confirm these effects on the transplanted cervical cancer (U27) mouse model in vivo. METHODS: Forty eight Kunming mice were randomly divided in to six groups: normal control group (Control group), U27 tumor model group (Model group), cyclophosphamide administration group (CTX group),low-dose ASMq group (ASMq...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27784939/fusarium-tricinctum-an-endophytic-fungus-exhibits-cell-growth-inhibition-and-antioxidant-activity
#16
M Vasundhara, Manoj Baranwal, Anil Kumar
An endophytic fungus (strain T6) isolated from Taxus baccata was studied for its effect on the growth of human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and peripheral blood mononuclear cells (PBMCs) as well as for its antioxidant activity. Based on morphological characters and internal transcribed spacer (ITS) sequence analysis, this fungus (strain T6) was identified as Fusarium tricinctum. This fungus has shown inhibition in the growth of the MCF-7 and HeLa cancer cell lines...
December 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27731648/phytochemical-constituents-and-biological-activities-of-cleome-iberica-dc
#17
Mahdi Moridi Farimani, Emad Nazarianpoor, Arezoo Rustaie, Maryam Akhbari
Phytochemical investigation of Cleome iberica DC. aerial parts led to the isolation and characterisation of six triterpenoid including glutinol (1), lupeol (2), β-sitosterol (3), cabraleadiol monoacetate (4), cabraleadiol (6) and daucosterol (8), one flavonoid, calycopterin (5) along with a fatty acid, tricosanoic acid (7). While studied samples showed weak potency in antimicrobial assessment, the acetone extract and some isolated compounds exhibited considerable cytotoxicity against cervical cancer cell line (HeLa) in MTT assay, among them calycopterin with IC50 equals to 5...
October 12, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27651811/chemical-constituents-and-biological-activities-of-two-iranian-cystoseira-species
#18
Afsaneh Yegdaneh, Alireza Ghannadi, Ladan Dayani
The marine environment represents approximately half of the global biodiversity and could provide unlimited biological resources for the production of therapeutic drugs. Marine seaweeds comprise few thousands of species representing a considerable part of the littoral biomass. Extracts of the Cystoseira indica and Cystoseira merica were subjected to phytochemical and cytotoxicity evaluation. The amount of total phenol was determined with Folin-Ciocalteu reagent. Cytotoxicity was characterized by IC50 of human cancer cell lines including MCF-7 (human breast adenocarcinoma), HeLa (cervical carcinoma), and HT-29 (human colon adenocarcinoma) using Sulforhodamin assay...
July 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27644619/purification-of-lovastatin-from-aspergillus-terreus-km017963-and-evaluation-of-its-anticancer-and-antioxidant-properties
#19
Sd Bhargavi, Vk Praveen, Salah Marium, M Sreepriya, J Savitha
Cervical cancer is the second most common malignancy in women worldwide and thus one of the leading causes of mortality in women. Lovastatin, a non polar, anticholesterol drug has previously been reported to exert antitumour activity in vitro. In the present study, lovastatin from Aspergillus terreus (KM017963) was purified by adsorption chromatography and evaluated for its anticancer and anti-oxidant properties with a human cervical cancer cell line (HeLa). Growth inhibitory and proapoptotic effects of purified lovastatin on HeLa cells were investigated by determining its influence on cell numbers, mitochondrial membrane potential (MMP), DNA fragmentation and antioxidant properties in terms of hydroxy radical scavenging effects as well as levels of total reduced glutathione...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27638711/carotenoids-biochemistry-pharmacology-and-treatment
#20
Alireza Milani, Marzieh Basirnejad, Sepideh Shahbazi, Azam Bolhassani
Carotenoids and retinoids have several similarities in biological activities such as antioxidant properties, the inhibition of malignant tumor growth, and the induction of apoptosis. Supplementation with carotenoids can influence cell growth regulation, and modulate gene expression and immune response. Epidemiologic studies have shown the correlation of high carotenoid intake from food sources with reduced risk of breast, cervical, ovarian, colorectal cancers, and cardiovascular or eye diseases. Cancer chemoprevention by dietary carotenoids involves some approaches including gap junctional intercellular communication (GJIC), growth factor signaling, cell cycle progression, differentiation-related proteins, retinoid-like receptors, antioxidant response element, nuclear receptors, AP-1 transcriptional complex, Wnt/β-Catenin pathway, and inflammatory cytokines...
September 16, 2016: British Journal of Pharmacology
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