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Nuclear and Molecular Medicine

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https://www.readbyqxmd.com/read/28088445/synthesis-and-exploration-of-novel-radiolabeled-bombesin-peptides-for-targeting-receptor-positive-tumor
#1
Kakali De, Indranil Banerjee, Samarendu Sinha, Shantanu Ganguly
Increasing evidence of peptide receptor overexpression in various cancer cells, warrant the development of receptor specific radiolabeled peptides for molecular imaging and therapy in nuclear medicine. Gastrin-releasing-peptide (GRP) receptor, are overexpressed in a variety of human cancer cells. The present study report the synthesis and biological evaluation of new bombesin (BBN) analogs, HYNIC-Asp-[Phe(13)]BBN(7-13)-NH-CH2-CH2-CH3:BA1, HYNIC-Pro-[Tyr(13)Met(14)]BBN(7-14)NH2:BA2 as prospective tumor imaging agent with compare to BBN(7-14)NH2:BS as standard...
January 11, 2017: Peptides
https://www.readbyqxmd.com/read/28081198/molecular-analysis-of-chinese-celastrus-and-tripterygium-and-implications-in-medicinal-and-pharmacological-studies
#2
Xian-Yun Mu, Liang-Cheng Zhao, Zhi-Xiang Zhang
Celastrus and Tripterygium species, which are used in traditional Chinese medicine, have attracted much attention due to their anti-tumor promoting and neuroprotective activities, in addition to their applications in autoimmune disorders. However, systematic relationships between them and among species are unclear, and it may disturb their further medicinal utilization. In the present study, the molecular analysis of combined chloroplast and nuclear markers of all Chinese Celastrus and Tripterygium was performed, and clear inter- and intra-genus relationships were presented...
2017: PloS One
https://www.readbyqxmd.com/read/28081156/generation-of-a-stable-transgenic-swine-model-expressing-a-porcine-histone-2b-egfp-fusion-protein-for-cell-tracking-and-chromosome-dynamics-studies
#3
Renan B Sper, Sehwon Koh, Xia Zhang, Sean Simpson, Bruce Collins, Jeff Sommer, Robert M Petters, Ignacio Caballero, Jeff L Platt, Jorge A Piedrahita
Transgenic pigs have become an attractive research model in the field of translational research, regenerative medicine, and stem cell therapy due to their anatomic, genetic and physiological similarities with humans. The development of fluorescent proteins as molecular tags has allowed investigators to track cell migration and engraftment levels after transplantation. Here we describe the development of two transgenic pig models via SCNT expressing a fusion protein composed of eGFP and porcine Histone 2B (pH2B)...
2017: PloS One
https://www.readbyqxmd.com/read/28071986/evaluation-of-a-two-year-routine-application-of-molecular-testing-of-thyroid-fine-needle-aspirations-fna-using-a-7-gene-panel-in-a-primary-referral-setting-in-germany
#4
Markus Eszlinger, Katharina Böhme, Maha Ullmann, Fabian Görke, Udo Siebolts, Anna Neumann, Christiane Franzius, Sabine Adam, Thomas Molwitz, Christian Landvogt, Bassam Amro, Anja Hach, Berit Feldmann, Dieter Graf, Antje Wefer, Rainer Niemann, Catharina Bullmann, Günther Klaushenke, Reinhard Santen, Gregor Tönshoff, Velimir Ivancevic, Andreas Kögler, Eberhard Bell, Bernd Lorenz, Gerald Kluge, Christoph Hartenstein, Ilka Ruschenburg, Ralf Paschke
BACKGROUND: Major differences with respect to the diagnostic performance of a "ruling in" approach in the pre-surgical diagnosis of indeterminate thyroid fine needle aspirations (FNAs) have been reported. Therefore, the aim of this prospective multicenter study was to investigate the specific diagnostic impact of mutation testing using a 7-gene-panel in a routine primary referral setting analyzing FNAs from endocrinology and nuclear medicine practices in Germany. METHODS: RNA and DNA was extracted from 564 routine air-dried FNA smears obtained from 64 physicians and cytologically graded by one experienced cytopathologist...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28069375/the-thyroid-hormone-nuclear-receptors-and-the-wnt-%C3%AE-catenin-pathway-an-intriguing-liaison
#5
REVIEW
Seham Skah, Joel Uchuya-Castillo, Maria Sirakov, Michelina Plateroti
The thyroid hormones, T3 and T4, control several developmental and homeostatic processes. From a molecular point of view, most of their actions depend on the activity of the thyroid hormone nuclear receptors (TRs), which are T3-modulated transcription factors. Recent studies have not only highlighted that the physiological response induced by T3 within a cell depends on the expression of specific TRs, but also that the functions of TRs are coordinated by and integrated in other signalling pathways. This is particularly the case for the multilevel interactions between TRs and the Wnt signalling pathway...
January 6, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28062715/molecular-imaging-and-therapy-with-a-purpose-a-renaissance-of-nuclear-medicine
#6
EDITORIAL
Johannes Czernin
No abstract text is available yet for this article.
January 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28056922/herbal-formula-xian-fang-huo-ming-yin-regulates-differentiation-of-lymphocytes-and-production-of-pro-inflammatory-cytokines-in-collagen-induced-arthritis-mice
#7
Jinyu Li, Yi Wei, Xue Li, Dashuai Zhu, Bo Nie, Jingwei Zhou, Lixia Lou, Bin Dong, Aiming Wu, Yongzhe Che, Meng Chen, Lingqun Zhu, Mingwei Mu, Limin Chai
BACKGROUND: Xian-Fang-Huo-Ming-Yin (XFHM), a traditional herbal formula, has been used to treat sores and carbuncles for hundreds of years in Asia. Nowadays, its clinical effects in treatment of rheumatoid arthritis (RA) have been validated. In this study, we want to study its possible molecular mechanisms of regulating the differentiation of lymphocytes and production of pro-inflammatory cytokines in collagen-induced arthritis (CIA) mice for RA treatment. METHODS: A high performance liquid chromatography-electrospray ionization/mass spectrometer (HPLC-ESI/MS(n)) system was used to analyze the constituents of XFHM granules...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056920/huatuo-zaizao-pill-promotes-functional-recovery-and-neurogenesis-after-cerebral-ischemia-reperfusion-in-rats
#8
Sijin Duan, Tian Wang, Jianqiao Zhang, Minmin Li, Chengwen Lu, Lijie Wang, Yan Zou, Fenghua Fu
BACKGROUND: Ischemic stroke is the third leading cause of death in adults worldwide and is the first leading cause of long-term disability. Neurogenesis plays an important role in promoting behavioral recovery after stroke. Huatuo Zaizao pill (HT), a traditional Chinese medicine, has been used clinically in China to promote the rehabilitation after stroke, but the underlying mechanism of action was still unclear. This study is to investigate the effects of HT on the functional recovery in a rat model of cerebral ischemia-reperfusion (I/R) injury, and the potential molecular mechanisms...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27999266/discovery-of-a-new-class-of-cathepsin-k-inhibitors-in-rhizoma-drynariae-as-potential-candidates-for-the-treatment-of-osteoporosis
#9
Zuo-Cheng Qiu, Xiao-Li Dong, Yi Dai, Gao-Keng Xiao, Xin-Luan Wang, Ka-Chun Wong, Man-Sau Wong, Xin-Sheng Yao
Rhizoma Drynariae (RD), as one of the most common clinically used folk medicines, has been reported to exert potent anti-osteoporotic activity. The bioactive ingredients and mechanisms that account for its bone protective effects are under active investigation. Here we adopt a novel in silico target fishing method to reveal the target profile of RD. Cathepsin K (Ctsk) is one of the cysteine proteases that is over-expressed in osteoclasts and accounts for the increase in bone resorption in metabolic bone disorders such as postmenopausal osteoporosis...
December 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27999264/systematic-understanding-of-mechanisms-of-a-chinese-herbal-formula-in-treatment-of-metabolic-syndrome-by-an-integrated-pharmacology-approach
#10
Meimei Chen, Fafu Yang, Xuemei Yang, Xinmei Lai, Yuxing Gao
Metabolic syndrome (MS) is becoming a worldwide health problem. Wendan decoction (WDD)-a famous traditional Chinese medicine formula-has been extensively employed to relieve syndromes related to MS in clinical practice in China. However, its pharmacological mechanisms still remain vague. In this study, a comprehensive approach that integrated chemomics, principal component analysis, molecular docking simulation, and network analysis was established to elucidate the multi-component and multi-target mechanism of action of WDD in treatment of MS...
December 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27997436/dihydromyricetin-reverses-mrp2-mediated-mdr-and-enhances-anticancer-activity-induced-by-oxaliplatin-in-colorectal-cancer-cells
#11
Ziyuan Wang, Xiaoting Sun, Yuanyuan Feng, Xuan Liu, Lihong Zhou, Hua Sui, Qing Ji, Qiukai E, Jia Chen, Lili Wu, Qi Li
Dihydromyricetin (DMY), extracted from the Chinese herbal medicine Ampelopsis grossedentata, possesses antitumor potential in different types of human cancer cells. Hence, its effects on drug resistance and molecular mechanisms in colorectal cancer (CRC) are still unknown. In our present study, we observed that DMY enhanced the chemosensitivity to oxaliplatin (OXA). DMY increased OXA-induced apoptosis and reduced 5(6)-carboxy-2',7'-dichlorofluorescein accumulation in OXA-resistant CRC HCT116/L-OHP cells. Our mechanistic study suggested that DMY treatment inhibited multidrug resistance protein 2 (MRP2) expression levels and promoter activity, indicating that DMY reduced not only MRP2 transcriptional and translational levels but also its function...
December 16, 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27994681/molecular-pain-imaging-by-nuclear-medicine-where-does-it-stand-and-where-is-it-going
#12
EDITORIAL
Jung-Joon Min
No abstract text is available yet for this article.
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27987555/clinical-amyloid-imaging
#13
REVIEW
Atul Mallik, Alex Drzezga, Satoshi Minoshima
Amyloid plaques, along with neurofibrillary tangles, are a neuropathologic hallmark of Alzheimer disease (AD). Recently, amyloid PET radiotracers have been developed and approved for clinical use in the evaluation of suspected neurodegenerative disorders. In both research and clinical settings, amyloid PET imaging has provided important diagnostic and prognostic information for the management of patients with possible AD, mild cognitive impairment (MCI), and other challenging diagnostic presentations. Although the overall impact of amyloid imaging is still being evaluated, the Society of Nuclear Medicine and Molecular Imaging and Alzheimer's Association Amyloid Imaging Task Force have created appropriate use criteria for the standard clinical use of amyloid PET imaging...
January 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27987029/erratum-to-the-need-of-standardization-and-of-large-clinical-studies-in-an-emerging-indication-of-18-f-fdg-pet-the-autoimmune-encephalitis
#14
Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, Gael Chetelat, Donna J Cross, Mehdi Djekidel, Alexander Drzezga, Ozgul Ekmekcioglu, Valentina Garibotto, Swen Hesse, Kazunari Ishii, Lida Jafari, Adriaan A Lammertsma, Ian Law, Dana Mathews, Satoshi Minoshima, Karina Mosci, Marco Pagani, Sabina Pappata, Daniel Hillel Silverman, Alberto Signore, Elsmarieke Van De Giessen, Victor Villemagne, Henryk Barthel
No abstract text is available yet for this article.
December 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27982094/huangqin-tang-ameliorates-dextran-sodium-sulphate-induced-colitis-by-regulating-intestinal-epithelial-cell-homeostasis-inflammation-and-immune-response
#15
Ying Zou, Jiantao Lin, Wenyang Li, Zhuguo Wu, Zhiwei He, Guoliang Huang, Jian Wang, Caiguo Ye, Xiaoyan Cheng, Congcong Ding, Xuebao Zheng, Honggang Chi
Huangqin-tang (HQT) is a traditional Chinese medicine (TCM) formula widely used for the treatment of inflammatory bowel disease in China. However, the molecular mechanisms by which HQT protects the colon are unclear. We studied the protective effects of HQT and the underlying mechanisms in an experimental mouse model and in vitro. In vivo, dextran sodium sulphate (DSS)-induced acute and chronic colitis were significantly ameliorated by HQT as gauged by phenotypic, histopathologic and inflammatory manifestations of the disease...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27981732/clinical-impact-of-68-ga-psma-pet-ct-in-prostate-cancer-patients-with-rising-psa-after-treatment-with-curative-intent-preliminary-analysis-of-a-multidisciplinary-approach
#16
S Albisinni, C Artigas, F Aoun, I Biaou, J Grosman, T Gil, E Hawaux, K Limani, F Otte, A Peltier, S Sideris, N Sirtaine, P Flamen, R van Velthoven
BACKGROUND: To assess the impact of (68) Ga-(HBED-CC)-PSMA (Prostate Specific Membrane Antigen) PET/CT in the clinical management of PCa patients with rising PSA after treatment with curative intent. (68) Ga-PSMA PET/CT scan is a novel molecular imaging technique in the field of prostate cancer (PCa). METHODS: 131 consecutive patients were referred to our center for a (68) Ga-PSMA PET/CT in the setting of recurring prostate cancer. 11/131(8%) presented persistent PSA after radical prostatectomy, while 120/131 (92%) were referred for biochemical recurrence after surgery, radiotherapy or both...
December 15, 2016: BJU International
https://www.readbyqxmd.com/read/27980055/cell-scientist-to-watch-megan-king
#17
(no author information available yet)
Megan king received her BA in biochemistry from Brandeis University and then pursued a PhD degree in Biochemistry and Molecular Biophysics at the University of Pennsylvania working in the group of Mark Lemmon. For her postdoctoral training, Megan chose the laboratory of Günter Blobel at the Rockefeller University in New York. Since starting her own group at the Cell Biology Department at Yale School of Medicine in 2009, Megan was named a Searle Scholar and her work has been recognised with the NIH Director's New Innovator Award in 2011...
December 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27924510/global-protein-expression-analysis-of-molecular-markers-of-ds-1-47-a-component-of-implantation-promoting-traditional-chinese-medicine
#18
Yan-Ling Li, Xiao-Yan Zhang, Yu Leng, Yan-Li Wu, Jing Li, Yun-Xia Wu
This study investigated the molecular markers of DS-1-47, a component of an implantation- promoting traditional Chinese medicine consisting of Astragalus mongholicus, Atractylodes macrocephala, Scutellaria baicalensis and Dipsacales, in an attempt to clarify the molecular mechanism and action targets of DS-1-47. Controlled ovarian stimulation (COS) method was used to establish the implantation dysfunction models of mice. Animals were divided into normal pregnant group, COS model group and DS-1-47 group. Laser capture microdissection-double dimensional electrophoresis-mass spectrum (LCM-DE-MS) was used to analyze the uterine protein molecules that were possibly involved in the promotion of implantation...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27924371/the-need-of-standardization-and-of-large-clinical-studies-in-an-emerging-indication-of-18-f-fdg-pet-the-autoimmune-encephalitis
#19
EDITORIAL
Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, Gael Chetelat, Donna J Cross, Mehdi Djekidel, Alexander Drzezga, Ozgul Ekmekcioglu, Valentina Garibotto, Swen Hesse, Kazunari Ishii, Lida Jafari Saraf, Adriaan A Lammertsma, Ian Law, Dana Mathews, Satoshi Minoshima, Karina Mosci, Marco Pagani, Sabina Pappata, Daniel Hillel Silverman, Alberto Signore, Elsmarieke Van De Giessen, Victor Villemagne, Henryk Barthel
No abstract text is available yet for this article.
December 6, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27919258/preparation-and-structural-determination-of-four-metabolites-of-senkyunolide-i-in-rats-using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-and-nuclear-magnetic-resonance-spectra
#20
Qiang Ma, Cong Ma, Fei Wu, Yao-Kun Xiong, Yi Feng, Shuang Liang
BACKGROUND: Senkyunolide I (SEI) is one of the most important bioactive phthalides of Ligusticum chuanxiong Hort. (Umbelliferae), a Traditional Chinese Medicine. Our previous studies suggested that it might be developed as a potential treatment for migraine. METHODS: In this paper, we aimed to isolate and characterize the main metabolites of SEI after gavage feeding in rats. Their structures were identified precisely on the basis of nuclear magnetic resonance (NMR) spectroscopy and UPLC/Q-TOF-MS spectrometry...
December 5, 2016: BMC Complementary and Alternative Medicine
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