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Nuclear and Molecular Medicine

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https://www.readbyqxmd.com/read/28804492/population-genetic-differentiation-and-taxonomy-of-three-closely-related-species-of-saxifraga-saxifragaceae-from-southern-tibet-and-the-hengduan-mountains
#1
Qing-Bo Gao, Yan Li, Zhuo-Ma Gengji, Richard J Gornall, Jiu-Li Wang, Hai-Rui Liu, Liu-Kun Jia, Shi-Long Chen
The effects of rapid, recent uplift of the Hengduan Mountains on evolution and diversification of young floristic lineages still remain unclear. Here, we investigate diversification of three closely related Saxifraga species with a distribution restricted to the Hengduan Mountains (HM) and southern Tibet, and comment on their taxonomy based on molecular evidence. Three chloroplast DNA fragments (rbcL, trnL-F, trnS-G) and the nuclear ribosomal DNA internal transcribed spacer (ITS) were employed to study genetic structure across 104 individuals from 12 populations of Saxifraga umbellulata, S...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28754101/herbal-formula-sc-e1-suppresses-lipopolysaccharide-stimulated-inflammatory-responses-through-activation-of-nrf2-ho-1-signaling-pathway-in-raw-264-7-macrophages
#2
Ju-Yeon Park, Young-Won Kwon, Soo Chil Lee, Sun-Dong Park, Ju-Hee Lee
BACKGROUND: SC-E1 is a novel herbal formula consisting of five oriental medicinal herbs used frequently in traditional herbal medicine for the treatment of inflammatory diseases in Korea. This study examined the effects of SC-E1 on lipopolysaccharide (LPS)-stimulated macrophages and the molecular mechanism involved. METHODS: The cytotoxic effect of the SC-E1 extract was evaluated in RAW 264.7 cells by MTT assay. The effects of SC-E1 on the free radical scavenging and generation of intracellular reactive oxygen species were measured using DPPH and DCFH-DA, respectively...
July 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28752226/highlights-of-articles-published-in-annals-of-nuclear-medicine-2016
#3
REVIEW
Hossein Jadvar
This article is the first installment of highlights of selected articles published during 2016 in the Annals of Nuclear Medicine, an official peer-reviewed journal of the Japanese Society of Nuclear Medicine. A companion article highlighting selected articles published during 2016 in the European Journal of Nuclear Medicine and Molecular Imaging, which is the official peer-reviewed journal of the European Association of Nuclear Medicine, will also appear in the Annals Nuclear Medicine. This new initiative by the respective journals will continue as an annual endeavor and is anticipated to not only enhance the scientific collaboration between Europe and Japan but also facilitate global partnership in the field of nuclear medicine and molecular imaging...
July 28, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28745237/anethole-inhibits-the-proliferation-of-human-prostate-cancer-cells-via-induction-of-cell-cycle-arrest-and-apoptosis
#4
Ayman Ibrahim Elkady
BACKGROUND: Prostate cancer-associated mortality is increasing at an alarming rate, which highlights the inevitability for unearthing novel agent for the management of this disease. Anethole, a major constituent of Foeniculum vulgare (fennel) essential oil, is widely used in folk medicine; it possesses anti-oxidant, anti-inflammatory, anti-proliferative and tumoricidal potentialities. OBJECTIVE: The current research was conducted to assess the impact of anethole on prostate cancer cell line, PC-3, and to delineate the molecular mechanism of action...
July 25, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28744708/topics-of-nuclear-medicine-research-in-europe
#5
REVIEW
Masayuki Inubushi, Tomohiro Kaneta, Takayoshi Ishimori, Etsuko Imabayashi, Atsutaka Okizaki, Naohiko Oku
Last year in the European Journal of Nuclear Medicine and Molecular Imaging, we introduced some recent nuclear medicine research conducted in Japan. This was favorably received by European readers in the main. This year we wish to focus on the Annals of Nuclear Medicine on some of the fine nuclear medicine research work executed in Europe recently. In the current review article, we take up five topics: prostate-specific membrane antigen imaging, recent advances in radionuclide therapy, [(18)F]fluorodeoxyglucose positron-emission tomography (PET) for dementia, quantitative PET assessment of myocardial perfusion, and iodine-124 ((124)I)...
July 25, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28736875/assessment-of-unilateral-ureter-obstruction-with-multi-parametric-mri
#6
Feng Wang, Keiko Takahashi, Hua Li, Zhongliang Zu, Ke Li, Junzhong Xu, Raymond C Harris, Takamune Takahashi, John C Gore
PURPOSE: Quantitative multi-parametric MRI (mpMRI) methods may allow the assessment of renal injury and function in a sensitive and objective manner. This study aimed to evaluate an array of MRI methods that exploit endogenous contrasts including relaxation rates, pool size ratio (PSR) derived from quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST), nuclear Overhauser enhancement (NOE), and apparent diffusion coefficient (ADC) for their sensitivity and specificity in detecting abnormal features associated with kidney disease in a murine model of unilateral ureter obstruction (UUO)...
July 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28736318/psma-targeted-18-f-dcfpyl-pet-ct-in-the-preoperative-staging-of-men-with-high-risk-prostate-cancer-results-of-a-prospective-phase-ii-single-center-study
#7
Michael A Gorin, Steven P Rowe, Hiten D Patel, Igor Vidal, Margarita Mana-Ay, Mehrbod S Javadi, Lilja B Solnes, Ashley E Ross, Edward M Schaeffer, Trinity J Bivalacqua, Alan W Partin, Kenneth J Pienta, Zsolt Szabo, Angelo M De Marzo, Martin G Pomper, Mohamad E Allaf
PURPOSE: To prospectively evaluate the diagnostic performance of PSMA-targeted (18)F-DCFPyL PET/CT in the preoperative staging of men at high risk of harboring metastatic prostate cancer despite a negative conventional staging evaluation. MATERIALS AND METHODS: Men with clinically localized high or very-high risk prostate cancer were imaged with (18)F-DCFPyL PET/CT prior to undergoing radical prostatectomy with a standardized pelvic lymph node dissection. PET/CT scans were interpreted by two blinded nuclear medicine readers and were assessed for inter-reader variability as well as diagnostic accuracy for pelvic lymph node staging...
July 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28736228/dbz-is-a-putative-ppar%C3%AE-agonist-that-prevents-high-fat-diet-induced-obesity-insulin-resistance-and-gut-dysbiosis
#8
Pengfei Xu, Fan Hong, Jialin Wang, Jing Wang, Xia Zhao, Sheng Wang, Tingting Xue, Jingwei Xu, Xiaohui Zheng, Yonggong Zhai
BACKGROUND: The nuclear receptor PPARγ is an effective pharmacological target for some types of metabolic syndrome, including obesity, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. However, the current PPARγ-targeting thiazolidinedione drugs have undesirable side effects. Danshensu Bingpian Zhi (DBZ), also known as tanshinol borneol ester derived from Salvia miltiorrhiza, is a synthetic derivative of natural compounds used in traditional Chinese medicine for its anti-inflammatory activity...
July 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28734900/molecular-imaging-in-stem-cell-based-therapies-of-cardiac-diseases
#9
REVIEW
Xiang Li, Marcus Hacker
In the past 15years, despite regenerative medicine has shown great potential for cardiovascular diseases, the outcome and safety of stem cell transplantation has shown controversial results in the published literature. Medical imaging might be useful for monitoring and quantification transplanted cells within the heart and to serially characterize the effects of stem cell therapy of the myocardium. From the multiple available noninvasive imaging techniques, magnetic resonance imaging and nuclear imaging by positron (PET) or single photon emission computer tomography (SPECT) are the most used clinical approaches to follow the fate of transplanted stem cells in vivo...
July 19, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28733231/tussilagonone-induced-nrf2-pathway-activation-protects-hepg2-cells-from-oxidative-injury
#10
Kyung-Mi Lee, Tae Yeon Kwon, Unwoo Kang, Eun Kyoung Seo, Ji Ho Yun, Chu Won Nho, Yeong Shik Kim
Tussilagonone is a compound derived from the medicinal plant Tussilago farfara L., which is used as a traditional medicine for respiratory diseases, including asthma and pneumonia. Recent reports suggest that tussilagonone exhibits anti-inflammatory effects; however, the scope of protective functions has not been elucidated yet. In this study, we demonstrate that tussilagonone enhances cellular detoxification by increasing quinone reductase activity in Hepa1c1c7 cells. In addition, tussilagonone decreased tert-butyl hydroperoxide(t-BHP)-induced ROS production and cell death, suggesting that it also acts as a potent antioxidant...
July 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28731804/nuclear-medicine-and-molecular-imaging-an-impactful-decade-of-contributions-to-patient-care-and-driving-precision-medicine
#11
Rathan M Subramaniam
No abstract text is available yet for this article.
August 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28723715/novel-weight-based-dose-threshold-for-18f-naf-pet-ct-imaging-using-advanced-pet-ct-systems-a-potential-tool-for-reducing-radiation-burden
#12
Fahad Marafi, Abdulreda Esmail, Rashid Rasheed, Fareeda Alkandari, Sharjeel Usmani
BACKGROUND: Fluorine-18-sodium fluoride (F-NaF) PET/CT is an important tool for detecting and evaluating metastatic bone cancer. Besides traditional dose metrics, recent methods such as real-time dose mapping, dose calculation from DICOM information, and their relevance to entrance skin exposure are currently in use to reduce the radiation burden. In this study, we have analyzed the data of 1062 patients retrospectively to evaluate patterns of absorbed dose for institutional weight-based dose protocol as compared with fixed dose method guidelines of Society of Nuclear Medicine and Molecular Imaging (SNMMI)...
July 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28721818/eurycoma-longifolia-a-potential-phytomedicine-for-the-treatment-of-cancer-evidence-of-p53-mediated-apoptosis-in-cancerous-cells
#13
Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid
BACKGROUND: Eurycoma longifolia is a well-documented herbal medicine that has gained widespread recognition due to its versatile pharmacological activities including anticancer, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer. Plethora of in vitro and in vivo studies evidenced their excellent anti-proliferative and anticancer efficacy against various types of human cancers. OBJECTIVE: This review was aimed to critically analyze the therapeutic viability and anticancer efficacy of Eurycoma longifolia in the treatment of cancer and also to propose its molecular and translational mechanism of cytotoxicity against cancerous cells...
July 18, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28720093/solanum-nigrum-unripe-fruit-fraction-attenuates-adriamycin-resistance-by-down-regulating-multi-drug-resistance-protein-mdr-1-through-jak-stat-pathway
#14
Sankar Jagadeeshan, Diana David, S Jisha, S Manjula, S Asha Nair
BACKGROUND: Solanum nigrum, herbal plant that commonly grows in temperate climate zone, has been used as a traditional folk medicine whose ripen fruits were proven to exhibit anti-tumor properties. In traditional Chinese medicine, it has been used for centuries to cure inflammation, edema, mastitis and hepatic cancer and in the Ayurvedic system of traditional medicine in India, S. nigrum is applied against enteric diseases, ulcer, diarrhea and skin diseases. A methanolic glycosidic extract fraction of unripe fruit of S...
July 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28715874/detection-of-bacterial-infection-by-a-technetium-99m-labeled-peptidoglycan-aptamer
#15
Iêda Mendes Ferreira, Camila Maria de Sousa Lacerda, Sara Roberta Dos Santos, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Nuclear medicine clinicians are still waiting for the optimal scintigraphic imaging agents capable of distinguishing between infection and inflammation, and between fungal and bacterial infections. Aptamers have several properties that make them suitable for molecular imaging. In the present study, a peptidoglycan aptamer (Antibac1) was labeled with (99m)Tc and evaluated by biodistribution studies and scintigraphic imaging in infection-bearing mice. Labeling with (99m)Tc was performed by the direct method and the complex stability was evaluated in saline, plasma and in the molar excess of cysteine...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28713409/phylogenetic-resolution-in-juglans-based-on-complete-chloroplast-genomes-and-nuclear-dna-sequences
#16
Wenpan Dong, Chao Xu, Wenqing Li, Xiaoman Xie, Yizeng Lu, Yanlei Liu, Xiaobai Jin, Zhili Suo
Walnuts (Juglans of the Juglandaceae) are well-known economically important resource plants for the edible nuts, high-quality wood, and medicinal use, with a distribution from tropical to temperate zones and from Asia to Europe and Americas. There are about 21 species in Juglans. Classification of Juglans at section level is problematic, because the phylogenetic position of Juglans cinerea is disputable. Lacking morphological and DNA markers severely inhibited the development of related researches. In this study, the complete chloroplast genomes and two nuclear DNA regions (the internal transcribed spacer and ubiquitin ligase gene) of 10 representative taxa of Juglans were used for comparative genomic analyses in order to deepen the understanding on the application value of genetic information for inferring the phylogenetic relationship of the genus...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28706254/mir-30a-targets-il-1%C3%AE-and-regulates-islet-functions-as-an-inflammation-buffer-and-response-factor
#17
Xin Jiang, Chenke Xu, Fan Lei, Meijian Liao, Wei Wang, Naihan Xu, Yaou Zhang, Weidong Xie
Diabetes is an inflammatory disease. Inflammation plays an important role in islet functions. However, the exact mechanisms by which inflammation affects islet functions remain unclear. In this study, we investigated the regulatory effects of miR-30a on inflammation and islet functions. The results indicate that miR-30a serves as an inflammation-resolving buffer factor by targeting interleukin 1a (IL-1α) in immune cells and in islet cells, which might play an important role in inflammation homeostasis. miR-30a ameliorates islet functions in an inflammatory micro-environment by targeting the IL-1α/nuclear factor kappa B (NFKB) p65 subunit (p65)/p62 (SQSTM1)/insulin axis, which can be developed into a novel antidiabetic approach...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28673474/new-developments-and-future-challenges-of-nuclear-medicine-and-molecular-imaging-for-pulmonary-embolism
#18
Pierre-Yves Le Roux, Philippe Robin, Pierre-Yves Salaun
Although widely validated, current tests for pulmonary embolism (PE) diagnosis, i.e. computed tomography pulmonary angiography (CTPA) and V/Q planar scintigraphy, have some limitations. Drawbacks of CTPA include the radiation dose, some contra indications and a rising concern about a possible overdiagnosis/overtreatment of PE. On the other hand, V/Q planar scintigraphy has a high rate of non-diagnostic tests responsible for complex diagnostic algorithms. Since the PIOPED study, imaging equipment and radiopharmaceuticals have greatly evolved allowing the introduction of techniques that improve imaging of lung ventilation and perfusion...
June 27, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28664142/molecular-mechanisms-of-anticancer-activity-of-deoxyelephantopin-in-cancer-cells
#19
Farha Arakkaveettil Kabeer, Dhanya Sethumadhavan Rajalekshmi, Mangalam Sivasankaran Nair, Remani Prathapan
BACKGROUND: Deoxyelephantopin (DOE) is a natural bioactive sesquiterpene lactone from Elephantopus scaber, a traditionally relevant herb in Chinese and Indian medicine. It has shown promising anticancer effects against a broad spectrum of cancers. METHODS: We examined the effect of DOE on growth, autophagy, apoptosis, cell cycle progression, metastasis, and various molecular signaling pathways in cancer cells, and endeavored to decipher the molecular mechanisms underlying its effect...
June 2017: Integrative medicine research
https://www.readbyqxmd.com/read/28655324/the-topical-application-of-low-temperature-argon-plasma-enhances-the-anti-inflammatory-effect-of-jaun-ointment-on-dncb-induced-nc-nga-mice
#20
Jeong-Hae Choi, Yeon-Suk Song, Hae-June Lee, Gyoo-Cheon Kim, Jin-Woo Hong
BACKGROUND: Jaun-ointment (JO), also known as Shiunko in Japan, is one of the most popular medicinal formulae used in Korean traditional medicine for the external treatment of skin wound and inflammatory skin conditions. Since JO is composed of crude mixture of two herbal extracts (radix of Lithospermum erythrorhizon Siebold & Zucc and Angelica gigas Nakai), those been proved its anti-inflammatory activities in-vitro and in-vivo, JO has been expected as a good alternative treatment option for atopic dermatitis (AD)...
June 27, 2017: BMC Complementary and Alternative Medicine
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