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male pattern baldness

Sandeep Mahapatra, Dhruva Kumar, Vignesh Subramanian, Swarup K Chakrabarti, Kaushik D Deb
Objective: Hair loss is a significant problem worldwide. The most common cause of hair loss in men is male androgenetic alopecia, male pattern baldness, which is primarily due to the presence of nonfunctional or dead hair follicles in the scalp. Hair follicular unit transplantation has been a widely used technique to transplant hair follicles into bald areas. Although follicular unit transplantation generally gives satisfactory hair transplantation, efforts have been made to further increase the efficacy of follicular unit transplantation in hair regeneration...
September 2016: Journal of Clinical and Aesthetic Dermatology
Muhammad Ahmad
Various classifications for male pattern baldness are mentioned in the literature. The 'Norwood's classification is the most commonly used but it has certain limitations. The new system has included 'three' extra features which were not mentioned in any other classification. It provides an opportunity to document the full and correct picture while documenting male pattern baldness. It also aids in assessing the treatment for various degrees of baldness.
July 2016: Journal of Cutaneous and Aesthetic Surgery
Visalini Nair-Shalliker, Sarsha Yap, Carlos Nunez, Sam Egger, Jennifer Rodger, Manish I Patel, Dianne L O'Connell, Freddy Sitas, Bruce K Armstrong, David P Smith
Prostate cancer (PC) is the most common non-cutaneous cancer in men worldwide. The relationships between PC and possible risk factors for PC cases (n = 1,181) and male controls (n = 875) from the New South Wales (NSW) Cancer, Lifestyle and Evaluation of Risk Study (CLEAR) were examined in this study. The associations between PC risk and paternal history of PC, body mass index (BMI), medical conditions, sexual behaviour, balding pattern and puberty, after adjusting for age, income, region of birth, place of residence, and PSA testing, were examined...
February 1, 2017: International Journal of Cancer. Journal International du Cancer
Didone Frigerio, Lara Cibulski, Sonja C Ludwig, Irene Campderrich, Kurt Kotrschal, Claudia A F Wascher
Individual reproductive success largely depends on the ability to optimize behaviour, immune function and the physiological stress response. We have investigated correlations between behaviour, faecal steroid metabolites, immune parameters, parasite excretion patterns and reproductive output in a critically endangered avian species, the Northern Bald Ibis (Geronticus eremita). In particular, we related haematocrit, heterophil/lymphocyte ratio, excreted immune-reactive corticosterone metabolites and social behaviour with parasite excretion and two individual fitness parameters, namely, number of eggs laid and number of fledglings...
2016: Journal of Ornithology
Wen-Qing Li, Eunyoung Cho, Jiali Han, Martin A Weinstock, Abrar A Qureshi
We examined the association between male-pattern baldness and risk of incident skin cancer, including invasive melanoma, invasive squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) in a prospective analysis, based on 36,032 participants from the Health Professionals' Follow-up Study. In 1992, participants reported their status of male-pattern baldness at age 45 years by choosing from five crown-view pictograms based on Norwood's classification. Diagnosis of skin cancers was reported biennially and information on melanoma and SCC was pathologically confirmed...
December 15, 2016: International Journal of Cancer. Journal International du Cancer
Glynis Ablon
BACKGROUND: Male pattern baldness, or androgenetic alopecia, affects approximately 50% of the adult population and can cause poor self-image, low self-esteem and have a significant negative impact on the quality of life. An oral nutraceutical supplement based on a marine complex formulation has previously been reported to significantly increase the number of terminal hairs in women with thinning hair. AIMS: The objective of this double-blind, placebo-controlled study was to confirm the beneficial effects of a similar marine complex supplement in adult male subjects with thinning hair (Viviscal(®) Man; Lifes2good, Inc...
August 9, 2016: Journal of Cosmetic Dermatology
Ralph M Trüeb
Based on observations of Julianne Imperato-McGinley of Cornell Medical College, New York presented at a conference on birth defects in 1974 on a peculiar genetic disorder due to type 2 5α-reductase deficiency (5-ARD), oral finasteride was approved in 1992 by the U.S. Food and Drug Administration for treatment of benign prostatic hyperplasia (BPH), and in 1997 for treatment of male pattern baldness (MPB). This article is protected by copyright. All rights reserved.
August 4, 2016: Experimental Dermatology
A Freire-Aradas, C Phillips, A Mosquera-Miguel, L Girón-Santamaría, A Gómez-Tato, M Casares de Cal, J Álvarez-Dios, J Ansede-Bermejo, M Torres-Español, P M Schneider, E Pośpiech, W Branicki, Á Carracedo, M V Lareu
Individual age estimation has the potential to provide key information that could enhance and extend DNA intelligence tools. Following predictive tests for externally visible characteristics developed in recent years, prediction of age could guide police investigations and improve the assessment of age-related phenotype expression patterns such as hair colour changes and early onset of male pattern baldness. DNA methylation at CpG positions has emerged as the most promising DNA tests to ascertain the individual age of the donor of a biological contact trace...
September 2016: Forensic Science International. Genetics
Sajid Ali, Muhammad Nisar, Zarbad Shah
CONTEXT: Among the 4-azasteroids, finasteride is biologically the most important compound having preventive effect against male pattern baldness (MPH) and benign prostatic hyperplasia commonly called enlargement of prostate gland. OBJECTIVE: The microbial transformation of finasteride by fungus Aspergillus niger (ATCC 10549) has been investigated to obtain biologically more potent derivatives. MATERIALS AND METHODS: Fermentation of finasteride was performed with filamentous fungus Aspergillus niger (ATCC 10549)...
November 2016: Pharmaceutical Biology
Emre Can Polat, Levent Ozcan, Alper Otunctemur, Emin Ozbek
We aimed to investigate the relationship among urinary stone disease, androgenetic alopecia (AGA), and serum testosterone (T) levels. Between January 2008 and November 2015, we retrospectively investigated the biochemical parameters and anthropometric characteristics (height and weight) of 200 patients who had urinary tract stones. For the control group, we selected at random 168 participants who had no history of urolithiasis. Demographic data, such as participants' age, body mass index (BMI), hypertension (HT), diabetes mellitus (DM), baldness pattern, and serum T level were recorded...
October 2016: Urolithiasis
Emine Colgecen, Huseyin Ede, Mustafa Fatih Erkoc, Yurdanur Akyuz, Ali Riza Erbay
BACKGROUND: Androgenetic alopecia (AGA) is the most commonly encountered baldness pattern in men. Epicardial fat tissue is found on the cardiac surface between the myocardium and visceral pericardium. Both AGA and epicardial fat thickness (EFT) are related to coronary artery disease, which is also reflected by an increase in carotid intima media thickness (CIMT). OBJECTIVE: The purpose of this study was to investigate the relation of AGA severity with EFT. METHODS: One hundred twenty-six male patients with AGA aged 18 to 55 years without histories of chronic disease were enrolled...
April 2016: Annals of Dermatology
Mrinal Gupta, Venkataram Mysore
Patterned hair loss is the most common cause of hair loss seen in both the sexes after puberty. Numerous classification systems have been proposed by various researchers for grading purposes. These systems vary from the simpler systems based on recession of the hairline to the more advanced multifactorial systems based on the morphological and dynamic parameters that affect the scalp and the hair itself. Most of these preexisting systems have certain limitations. Currently, the Hamilton-Norwood classification system for males and the Ludwig system for females are most commonly used to describe patterns of hair loss...
January 2016: Journal of Cutaneous and Aesthetic Surgery
Sami Sarre, Liisa Määttänen, Teuvo L J Tammela, Anssi Auvinen, Teemu J Murtola
Objective The etiology of prostate cancer (PCa) is still unclear. This study aimed to investigate the association between PCa risk and the indicators of endogenous androgen production at puberty, male pattern baldness, over-the-counter use of non-steroidal anti-inflammatory drugs and vitamin supplement use. Materials and methods Participants in the third round of the Finnish Prostate Cancer Screening Trial were sent a survey on possible PCa risk factors and 11,795 out of 12,740 (93%) men returned the questionnaire...
August 2016: Scandinavian Journal of Urology
Venkataram Mysore, B M Shashikumar
BACKGROUND: Finasteride is a widely used drug in dermatology for the treatment of androgenetic alopecia. There are many reports of associated sexual side effects. This article reviews the use of once-daily 1 mg finasteride in androgenetic alopecia and its associated sexual adverse effects. METHODS: A literature search was performed to collect data on the use of finasteride in male pattern baldness. Relevant literature published till March 2014 was obtained from MEDLINE, EMBASE, CINAHL, Cochrane registers and LILACS...
March 2016: Indian Journal of Dermatology, Venereology and Leprology
Azumi Nagasawa, Etsuji Wakisaka, Hideshi Kidena, Tomoko Nomura, Mitsuyuki Hotta, Hiroyuki Taguchi, Shigeru Moriwaki
INTRODUCTION: trans-3,4'-Dimethyl-3-hydroxyflavanone (t-flavanone) is a derivative of astilbin that actively stimulates hair growth. The aim of the present study was to identify the mechanisms of action of t-flavanone on hair growth. METHODS: A double-blind usage test was performed with healthy volunteers who had androgenic alopecia (AGA). The subjects were divided into three groups with equal average baldness. The members in each group applied a vasodilator-containing hair lotion supplemented with either 0, 0...
March 2016: Dermatology and Therapy
Cindy Ke Zhou, Paul H Levine, Sean D Cleary, Heather J Hoffman, Barry I Graubard, Michael B Cook
We used male pattern baldness as a proxy for long-term androgen exposure and investigated the association of dermatologist-assessed hair loss with prostate cancer-specific mortality in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. From the baseline survey (1971-1974), we included 4,316 men who were 25-74 years of age and had no prior cancer diagnosis. We estimated hazard ratios and used Cox proportional hazards regressions with age as the time metric and baseline hazard stratified by baseline age...
February 1, 2016: American Journal of Epidemiology
Rafael Tellez-Segura
CONTEXT: Androgenetic alopecia (AGA) is a frequent disorder characterized by progressive hair miniaturization in a very similar pattern among all affected men. The pathogenesis is related to androgen-inducible overexpression of transforming growth factor β-1 from balding dermal papilla cells, which is involved in epithelial inhibition and perifollicular fibrosis. Recent research shows that hair follicle androgen sensitivity is regulated by Hic-5, an androgen receptor co-activator which may be activated by the mechanical stimulation...
July 2015: International Journal of Trichology
Ragip Ertas, Ozcan Orscelik, Demet Kartal, Ali Dogan, Sule Ketenci Ertas, Ebru Guler Aydogdu, Ozcan Ascioglu, Murat Borlu
Numerous studies have investigated a probable association between androgenetic alopecia (AGA) and cardiovascular disease (CVD) by researching limited and dispersed parameters. We aimed to evaluate both traditional and non-traditional cardiovascular risk factors in male patients with early-onset AGA. This case-control study included 68 participants: 51 male patients with early-onset AGA and 17 healthy male controls. Patients with AGA were classified into three groups according to the Hamilton-Norwood scale and the presence of vertex hair loss...
June 2016: Blood Pressure
Fan Liu, Merel A Hamer, Stefanie Heilmann, Christine Herold, Susanne Moebus, Albert Hofman, André G Uitterlinden, Markus M Nöthen, Cornelia M van Duijn, Tamar Ec Nijsten, Manfred Kayser
The global demand for products that effectively prevent the development of male-pattern baldness (MPB) has drastically increased. However, there is currently no established genetic model for the estimation of MPB risk. We conducted a prediction analysis using single-nucleotide polymorphisms (SNPs) identified from previous GWASs of MPB in a total of 2725 German and Dutch males. A logistic regression model considering the genotypes of 25 SNPs from 12 genomic loci demonstrates that early-onset MPB risk is predictable at an accuracy level of 0...
June 2016: European Journal of Human Genetics: EJHG
Mustafa Resorlu, Eyup Burak Sancak, Fatma Uysal, Muhammet Arslan, Akif Diri, Gurhan Adam, Alpaslan Akbas, Abdullah Sariyildirim, Murat Tolga Gulpinar, Berkan Resorlu
OBJECTIVES: The objective of this study is to investigate whether patients with androgenetic alopecia were at risk in terms of urinary system stone disease. PATIENTS AND METHODS: Patients with no baldness (Hamilton-Norwood Scala [HNS] stage I) were categorized as Group I, those with hair loss in the frontal region (HNS stages II, III, IIIa, and IVa) as Group II, those with hair loss in the vertex region (HNS stage III-vertex, V) as Group III and those with hair loss in both vertex and frontal regions (HNS stages IV, Va, VI, and VII) as Group IV...
2016: Renal Failure
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