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https://www.readbyqxmd.com/read/28196072/genetic-prediction-of-male-pattern-baldness
#1
Saskia P Hagenaars, W David Hill, Sarah E Harris, Stuart J Ritchie, Gail Davies, David C Liewald, Catharine R Gale, David J Porteous, Ian J Deary, Riccardo E Marioni
Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x10-8). By splitting the cohort into a discovery sample of 40,000 and target sample of 12,000, we developed a prediction algorithm based entirely on common genetic variants that discriminated (AUC = 0...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28096933/the-association-of-male-pattern-baldness-and-risk-of-cancer-and-high-grade-disease-among-men-presenting-for-prostate-biopsy
#2
Ghazi Al Edwan, Bimal Bhindi, David Margel, Karen Chadwick, Antonio Finelli, Alexandre Zlotta, John Trachtenberg, Neil Fleshner
INTRODUCTION: Androgens have been implicated in both male pattern baldness (MPB) and prostate cancer (PCa). We set out to prospectively determine if men with independently assessed MPB are at higher risk for PCa at biopsy and determine if any grade associations exist. METHODS: We prospectively enrolled 394 eligible patients presenting for prostate biopsy and independently determined their MPB pattern using the validated modified Norwood classification system (0: no balding; 1: frontal balding; 2: mild vertex balding; 3: moderate vertex balding; 4: sever vertex balding)...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27853485/study-on-the-efficacy-of-platelet-rich-fibrin-matrix-in-hair-follicular-unit-transplantation-in-androgenetic-alopecia-patients
#3
Sandeep Mahapatra, Dhruva Kumar, Vignesh Subramanian, Swarup K Chakrabarti, Kaushik D Deb
Objective: Hair loss is a significant problem worldwide. The most common cause of hair loss in men is male androgenetic alopecia, male pattern baldness, which is primarily due to the presence of nonfunctional or dead hair follicles in the scalp. Hair follicular unit transplantation has been a widely used technique to transplant hair follicles into bald areas. Although follicular unit transplantation generally gives satisfactory hair transplantation, efforts have been made to further increase the efficacy of follicular unit transplantation in hair regeneration...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27761091/ahmad-s-nprt-system-a-practical-innovation-for-documenting-male-pattern-baldness
#4
Muhammad Ahmad
Various classifications for male pattern baldness are mentioned in the literature. The 'Norwood's classification is the most commonly used but it has certain limitations. The new system has included 'three' extra features which were not mentioned in any other classification. It provides an opportunity to document the full and correct picture while documenting male pattern baldness. It also aids in assessing the treatment for various degrees of baldness.
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27741552/adult-body-size-sexual-history-and-adolescent-sexual-development-may-predict-risk-of-developing-prostate-cancer-results-from-the-new-south-wales-lifestyle-and-evaluation-of-risk-study-clear
#5
Visalini Nair-Shalliker, Sarsha Yap, Carlos Nunez, Sam Egger, Jennifer Rodger, Manish I Patel, Dianne L O'Connell, Freddy Sitas, Bruce K Armstrong, David P Smith
Prostate cancer (PC) is the most common non-cutaneous cancer in men worldwide. The relationships between PC and possible risk factors for PC cases (n = 1,181) and male controls (n = 875) from the New South Wales (NSW) Cancer, Lifestyle and Evaluation of Risk Study (CLEAR) were examined in this study. The associations between PC risk and paternal history of PC, body mass index (BMI), medical conditions, sexual behaviour, balding pattern and puberty, after adjusting for age, income, region of birth, place of residence, and PSA testing, were examined...
February 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27570727/excretion-patterns-of-coccidian-oocysts-and-nematode-eggs-during-the-reproductive-season-in-northern-bald-ibis-geronticus-eremita
#6
Didone Frigerio, Lara Cibulski, Sonja C Ludwig, Irene Campderrich, Kurt Kotrschal, Claudia A F Wascher
Individual reproductive success largely depends on the ability to optimize behaviour, immune function and the physiological stress response. We have investigated correlations between behaviour, faecal steroid metabolites, immune parameters, parasite excretion patterns and reproductive output in a critically endangered avian species, the Northern Bald Ibis (Geronticus eremita). In particular, we related haematocrit, heterophil/lymphocyte ratio, excreted immune-reactive corticosterone metabolites and social behaviour with parasite excretion and two individual fitness parameters, namely, number of eggs laid and number of fledglings...
2016: Journal of Ornithology
https://www.readbyqxmd.com/read/27542665/male-pattern-baldness-and-risk-of-incident-skin-cancer-in-a-cohort-of-men
#7
Wen-Qing Li, Eunyoung Cho, Jiali Han, Martin A Weinstock, Abrar A Qureshi
We examined the association between male-pattern baldness and risk of incident skin cancer, including invasive melanoma, invasive squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) in a prospective analysis, based on 36,032 participants from the Health Professionals' Follow-up Study. In 1992, participants reported their status of male-pattern baldness at age 45 years by choosing from five crown-view pictograms based on Norwood's classification. Diagnosis of skin cancers was reported biennially and information on melanoma and SCC was pathologically confirmed...
December 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27506633/a-6-month-randomized-double-blind-placebo-controlled-study-evaluating-the-ability-of-a-marine-complex-supplement-to-promote-hair-growth-in-men-with-thinning-hair
#8
Glynis Ablon
BACKGROUND: Male pattern baldness, or androgenetic alopecia, affects approximately 50% of the adult population and can cause poor self-image, low self-esteem and have a significant negative impact on the quality of life. An oral nutraceutical supplement based on a marine complex formulation has previously been reported to significantly increase the number of terminal hairs in women with thinning hair. AIMS: The objective of this double-blind, placebo-controlled study was to confirm the beneficial effects of a similar marine complex supplement in adult male subjects with thinning hair (Viviscal(®) Man; Lifes2good, Inc...
December 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27489125/discriminating-in-favour-of-or-against-men-with-increased-risk-of-finasteride-related-side-effects
#9
Ralph M Trüeb
No abstract text is available yet for this article.
August 4, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27337627/development-of-a-methylation-marker-set-for-forensic-age-estimation-using-analysis-of-public-methylation-data-and-the-agena-bioscience-epityper-system
#10
A Freire-Aradas, C Phillips, A Mosquera-Miguel, L Girón-Santamaría, A Gómez-Tato, M Casares de Cal, J Álvarez-Dios, J Ansede-Bermejo, M Torres-Español, P M Schneider, E Pośpiech, W Branicki, Á Carracedo, M V Lareu
Individual age estimation has the potential to provide key information that could enhance and extend DNA intelligence tools. Following predictive tests for externally visible characteristics developed in recent years, prediction of age could guide police investigations and improve the assessment of age-related phenotype expression patterns such as hair colour changes and early onset of male pattern baldness. DNA methylation at CpG positions has emerged as the most promising DNA tests to ascertain the individual age of the donor of a biological contact trace...
September 2016: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/27181333/production-of-biologically-active-oxidized-derivatives-of-finasteride-through-metabolism-by-aspergillus-niger-culture
#11
Sajid Ali, Muhammad Nisar, Zarbad Shah
CONTEXT: Among the 4-azasteroids, finasteride is biologically the most important compound having preventive effect against male pattern baldness (MPH) and benign prostatic hyperplasia commonly called enlargement of prostate gland. OBJECTIVE: The microbial transformation of finasteride by fungus Aspergillus niger (ATCC 10549) has been investigated to obtain biologically more potent derivatives. MATERIALS AND METHODS: Fermentation of finasteride was performed with filamentous fungus Aspergillus niger (ATCC 10549)...
November 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27155830/relation-of-urinary-stone-disease-with-androgenetic-alopecia-and-serum-testosterone-levels
#12
Emre Can Polat, Levent Ozcan, Alper Otunctemur, Emin Ozbek
We aimed to investigate the relationship among urinary stone disease, androgenetic alopecia (AGA), and serum testosterone (T) levels. Between January 2008 and November 2015, we retrospectively investigated the biochemical parameters and anthropometric characteristics (height and weight) of 200 patients who had urinary tract stones. For the control group, we selected at random 168 participants who had no history of urolithiasis. Demographic data, such as participants' age, body mass index (BMI), hypertension (HT), diabetes mellitus (DM), baldness pattern, and serum T level were recorded...
October 2016: Urolithiasis
https://www.readbyqxmd.com/read/27081268/the-relation-of-androgenetic-alopecia-severity-with-epicardial-fat-thickness
#13
Emine Colgecen, Huseyin Ede, Mustafa Fatih Erkoc, Yurdanur Akyuz, Ali Riza Erbay
BACKGROUND: Androgenetic alopecia (AGA) is the most commonly encountered baldness pattern in men. Epicardial fat tissue is found on the cardiac surface between the myocardium and visceral pericardium. Both AGA and epicardial fat thickness (EFT) are related to coronary artery disease, which is also reflected by an increase in carotid intima media thickness (CIMT). OBJECTIVE: The purpose of this study was to investigate the relation of AGA severity with EFT. METHODS: One hundred twenty-six male patients with AGA aged 18 to 55 years without histories of chronic disease were enrolled...
April 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27081243/classifications-of-patterned-hair-loss-a-review
#14
REVIEW
Mrinal Gupta, Venkataram Mysore
Patterned hair loss is the most common cause of hair loss seen in both the sexes after puberty. Numerous classification systems have been proposed by various researchers for grading purposes. These systems vary from the simpler systems based on recession of the hairline to the more advanced multifactorial systems based on the morphological and dynamic parameters that affect the scalp and the hair itself. Most of these preexisting systems have certain limitations. Currently, the Hamilton-Norwood classification system for males and the Ludwig system for females are most commonly used to describe patterns of hair loss...
January 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/26927237/postscreening-follow-up-of-the-finnish-prostate-cancer-screening-trial-on-putative-prostate-cancer-risk-factors-vitamin-and-mineral-use-male-pattern-baldness-pubertal-development-and-non-steroidal-anti-inflammatory-drug-use
#15
Sami Sarre, Liisa Määttänen, Teuvo L J Tammela, Anssi Auvinen, Teemu J Murtola
Objective The etiology of prostate cancer (PCa) is still unclear. This study aimed to investigate the association between PCa risk and the indicators of endogenous androgen production at puberty, male pattern baldness, over-the-counter use of non-steroidal anti-inflammatory drugs and vitamin supplement use. Materials and methods Participants in the third round of the Finnish Prostate Cancer Screening Trial were sent a survey on possible PCa risk factors and 11,795 out of 12,740 (93%) men returned the questionnaire...
August 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/26924401/guidelines-on-the-use-of-finasteride-in-androgenetic-alopecia
#16
REVIEW
Venkataram Mysore, B M Shashikumar
BACKGROUND: Finasteride is a widely used drug in dermatology for the treatment of androgenetic alopecia. There are many reports of associated sexual side effects. This article reviews the use of once-daily 1 mg finasteride in androgenetic alopecia and its associated sexual adverse effects. METHODS: A literature search was performed to collect data on the use of finasteride in male pattern baldness. Relevant literature published till March 2014 was obtained from MEDLINE, EMBASE, CINAHL, Cochrane registers and LILACS...
March 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/26897375/t-flavanone-improves-the-male-pattern-of-hair-loss-by-enhancing-hair-anchoring-strength-a-randomized-double-blind-placebo-controlled-study
#17
Azumi Nagasawa, Etsuji Wakisaka, Hideshi Kidena, Tomoko Nomura, Mitsuyuki Hotta, Hiroyuki Taguchi, Shigeru Moriwaki
INTRODUCTION: trans-3,4'-Dimethyl-3-hydroxyflavanone (t-flavanone) is a derivative of astilbin that actively stimulates hair growth. The aim of the present study was to identify the mechanisms of action of t-flavanone on hair growth. METHODS: A double-blind usage test was performed with healthy volunteers who had androgenic alopecia (AGA). The subjects were divided into three groups with equal average baldness. The members in each group applied a vasodilator-containing hair lotion supplemented with either 0, 0...
March 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/26764224/male-pattern-baldness-in-relation-to-prostate-cancer-specific-mortality-a-prospective-analysis-in-the-nhanes-i-epidemiologic-follow-up-study
#18
Cindy Ke Zhou, Paul H Levine, Sean D Cleary, Heather J Hoffman, Barry I Graubard, Michael B Cook
We used male pattern baldness as a proxy for long-term androgen exposure and investigated the association of dermatologist-assessed hair loss with prostate cancer-specific mortality in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. From the baseline survey (1971-1974), we included 4,316 men who were 25-74 years of age and had no prior cancer diagnosis. We estimated hazard ratios and used Cox proportional hazards regressions with age as the time metric and baseline hazard stratified by baseline age...
February 1, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/26622151/involvement-of-mechanical-stress-in-androgenetic-alopecia
#19
Rafael Tellez-Segura
CONTEXT: Androgenetic alopecia (AGA) is a frequent disorder characterized by progressive hair miniaturization in a very similar pattern among all affected men. The pathogenesis is related to androgen-inducible overexpression of transforming growth factor β-1 from balding dermal papilla cells, which is involved in epithelial inhibition and perifollicular fibrosis. Recent research shows that hair follicle androgen sensitivity is regulated by Hic-5, an androgen receptor co-activator which may be activated by the mechanical stimulation...
July 2015: International Journal of Trichology
https://www.readbyqxmd.com/read/26585114/androgenetic-alopecia-as-an-indicator-of-metabolic-syndrome-and-cardiovascular-risk
#20
Ragip Ertas, Ozcan Orscelik, Demet Kartal, Ali Dogan, Sule Ketenci Ertas, Ebru Guler Aydogdu, Ozcan Ascioglu, Murat Borlu
Numerous studies have investigated a probable association between androgenetic alopecia (AGA) and cardiovascular disease (CVD) by researching limited and dispersed parameters. We aimed to evaluate both traditional and non-traditional cardiovascular risk factors in male patients with early-onset AGA. This case-control study included 68 participants: 51 male patients with early-onset AGA and 17 healthy male controls. Patients with AGA were classified into three groups according to the Hamilton-Norwood scale and the presence of vertex hair loss...
June 2016: Blood Pressure
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