Leena von Hertzen, Bruce Beutler, John Bienenstock, Martin Blaser, Patrice D Cani, Johan Eriksson, Martti Färkkilä, Tari Haahtela, Ilkka Hanski, Maria C Jenmalm, Juha Kere, Mikael Knip, Kimmo Kontula, Markku Koskenvuo, Charlotte Ling, Thomas Mandrup-Poulsen, Erika von Mutius, Mika J Mäkelä, Tiina Paunio, Göran Pershagen, Harald Renz, Graham Rook, Maria Saarela, Outi Vaarala, Marc Veldhoen, Willem M de Vos
Urban living in built environments, combined with the use of processed water and food, may not provide the microbial stimulation necessary for a balanced development of immune function. Many chronic inflammatory disorders, including allergic, autoimmune, metabolic, and even some behavioural disorders, are linked to alteration in the human commensal microbiota. Sedentary lifestyle is associated with reduced exposure to a broad spectrum of environmental micro-organisms and surplus energy balance, both risk factors of chronic inflammatory disorders...
May 2015: Annals of Medicine