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https://www.readbyqxmd.com/read/29202204/cost-effectiveness-of-yoga-for-managing-musculoskeletal-conditions-in-the-workplace
#1
N Hartfiel, G Clarke, J Havenhand, C Phillips, R T Edwards
Background: Back pain and musculoskeletal conditions negatively affect the health-related quality of life (HRQL) of employees and generate substantial costs to employers. Aims: To assess the cost-effectiveness of yoga for managing musculoskeletal conditions. Methods: A randomized controlled trial evaluated an 8-week yoga programme, with a 6-month follow-up, for National Health Service (NHS) employees. Effectiveness in managing musculoskeletal conditions was assessed using repeated-measures generalized linear modelling for the Roland-Morris Disability Questionnaire (RDQ) and the Keele STarT Back Screening Tool...
November 30, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29194127/core-outcome-measurement-instruments-for-clinical-trials-in-non-specific-low-back-pain
#2
Alessandro Chiarotto, Maarten Boers, Richard A Deyo, Rachelle Buchbinder, Terry P Corbin, Leonardo O P Costa, Nadine E Foster, Margreth Grotle, Bart W Koes, Francisco M Kovacs, Chung-Wei Christine Lin, Chris G Maher, Adam M Pearson, Wilco C Peul, Mark L Schoene, Dennis C Turk, Maurits W van Tulder, Caroline B Terwee, Raymond W Ostelo
To standardize outcome reporting in clinical trials of patients with non-specific low back pain (LBP), an international multidisciplinary panel recommended physical functioning, pain intensity, and health-related quality of life (HRQoL) as core outcome domains. Given the lack of consensus on measurement instruments for these three domains in patients with LBP, this study aimed to generate such consensus. The measurement properties of 17 patient-reported outcome measures for physical functioning, three for pain intensity, and five for HRQoL were appraised in three systematic reviews following COSMIN methodology...
November 24, 2017: Pain
https://www.readbyqxmd.com/read/29184289/proprioceptive-change-impairs-balance-control-in-older-patients-with-low-back-pain
#3
Tadashi Ito, Yoshihito Sakai, Kazunori Yamazaki, Kazuma Igarashi, Noritaka Sato, Kiyoko Yokoyama, Yoshifumi Morita
[Purpose] This study aims to determine the specific proprioceptive control strategy used during postural balance in older patients with low back pain (LBP) and non-LBP (NLBP) and to assess whether this strategy is related to proprioceptive decline and LBP. [Subjects and Methods] Pressure displacement center was determined in 47 older persons with LBP and 64 older persons with NLBP during upright stance on a balance board without vision. Gastrocnemius (GS) and lumbar multifidus muscle (LM) vibratory stimulations of 60 and 240-Hz, respectively, were applied to evaluate the relative contributions of different proprioceptive signals (relative proprioceptive weighting ratio, RPW) used in postural control...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29183384/core-health-outcomes-in-childhood-epilepsy-choice-protocol-for-the-selection-of-a-core-outcome-set
#4
Christopher Morris, Colin Dunkley, Frances M Gibbon, Janet Currier, Deborah Roberts, Morwenna Rogers, Holly Crudgington, Lucy Bray, Bernie Carter, Dyfrig Hughes, Catrin Tudur Smith, Paula R Williamson, Paul Gringras, Deb K Pal
BACKGROUND: There is increasing recognition that establishing a core set of outcomes to be evaluated and reported in trials of interventions for particular conditions will improve the usefulness of health research. There is no established core outcome set for childhood epilepsy. The aim of this work is to select a core outcome set to be used in evaluative research of interventions for children with rolandic epilepsy, as an exemplar of common childhood epilepsy syndromes. METHODS: First we will identify what outcomes should be measured; then we will decide how to measure those outcomes...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29174459/prognosis-of-sciatica-and-back-related-leg-pain-in-primary-care-the-atlas-cohort
#5
Kika Konstantinou, Kate M Dunn, Reuben Ogollah, Martyn Lewis, Danielle van der Windt, Elaine M Hay
BACKGROUND CONTEXT: Evidence is lacking on the prognosis and prognostic factors for back-related leg pain and sciatica in patients seeing their primary care physicians. This could guide timely appropriate treatment and referral decisions. PURPOSE: To describe prognosis and prognostic factors in primary care patients with low back-related leg pain, and sciatica. STUDY DESIGN: Prospective cohort study PATIENT SAMPLE: Adults visiting their family doctor with back-related leg pain in the United Kingdom...
November 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154811/a-systematic-review-highlights-the-need-to-investigate-the-content-validity-of-patient-reported-outcome-measures-for-physical-functioning-in-low-back-pain
#6
REVIEW
Alessandro Chiarotto, Raymond W Ostelo, Maarten Boers, Caroline B Terwee
OBJECTIVE: To summarize the evidence on content and structural validity of 17 patient-reported outcome measures (PROMs) to measure physical functioning in LBP. STUDY DESIGN AND SETTING: MEDLINE, EMBASE, CINAHL, PsycINFO, SportDiscus, and Google Scholar were searched (February 2017). Records on development, and studies assessing content validity or unidimensionality in patients with LBP were included. Two reviewers defined eligible studies and assessed their methodological quality with updated COSMIN standards...
November 14, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29138049/pain-neurophysiology-education-and-therapeutic-exercise-for-patients-with-chronic-low-back-pain-a-single-blind-randomized-controlled-trial
#7
Bodes Pardo Gema, Lluch Girbés Enrique, Roussel Nathalie A, Gallego Izquierdo Tomás, Jiménez Penick Virginia, Pecos Martín Daniel
AIM: To assess the effect of a pain neurophysiology education program plus therapeutic exercise for patients with chronic low back pain (CLBP). DESIGN: Single-blind randomized controlled trial. SETTING: Private clinic (Clínica Bonn) and Alcalá de Henares University, Madrid, Spain. PARTICIPANTS: 56 patients with CLBP for 6 months or more. INTERVENTION: Participants were randomized to receive either a therapeutic exercise (TE) program consisting of motor control, stretching, and aerobic exercises (TE group, n=28) or the same therapeutic exercise program in addition to a pain neurophysiology education program (PNE+TE group, n=28), conducted in two 30 to 50 minute sessions in groups of 4 to 6 participants...
November 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29122255/the-medium-term-effects-of-diadynamic-currents-in-chronic-low-back-pain-tens-versus-diadynamic-currents-a-randomised-follow-up-study
#8
Selcuk Sayilir, Mustafa Turgut Yildizgoren
OBJECTIVE: The aims of the study were to evaluate the medium-term effects of diadynamic (DD) currents on relieving symptoms/improving physical functionality in patients with chronic low back pain (LBP) and to compare the efficacy of DD versus TENS. METHODS: The patients were divided into two groups as the TENS group (n = 26) and the DD group (n = 29). Additional treatment of hot pack + therapeutic ultrasound was applied to all patients. The therapy programs were administered as a total of 10 sessions over a period of 2 weeks...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29116395/correlations-between-sedimentation-sign-dural-sac-cross-sectional-area-and-clinical-symptoms-of-degenerative-lumbar-spinal-stenosis
#9
Sangbong Ko
PURPOSE: In this study, we addressed the correlation between the cross-sectional area (CSA) of the dural sac and the nerve root sedimentation sign (SedSign) and the correlation between the distance of claudication and the CSA of the dural sac or SedSign in patients with lumbar spinal stenosis. We also evaluated the reliability of clinical symptom prediction. METHODS: We checked claudication distance using a questionnaire, and we gauged low back pain when standing, referred pain, and radiating pain using visual analog scale scores...
November 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29092070/radiopaque-gelified-ethanol-application-in-lumbar-intervertebral-soft-disc-herniations-croatian-multicentric-study
#10
Karlo Houra, Darko Perovic, Ivan Rados, Drazen Kvesic
Objective: Minimally invasive percutaneous spinal procedures are popular in trying to reduce spinal pain. The aim of this paper is to evaluate the safety of intervertebral disc chemonucleolysis and to report the effectiveness of a percutaneous, minimally invasive treatment for contained herniated intervertebral discs in the lumbar spine using the recently marketed radiopaque gelified ethanol. Methods: Pain relief before and after the procedure was self-evaluated by each patient using a verbal numeric scale (VNS) ranging from 0 to 10...
October 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29089169/a-randomized-double-blind-placebo-controlled-trial-of-naproxen-with-or-without-orphenadrine-or-methocarbamol-for-acute-low-back-pain
#11
Benjamin W Friedman, David Cisewski, Eddie Irizarry, Michelle Davitt, Clemencia Solorzano, Adam Nassery, Scott Pearlman, Deborah White, E John Gallagher
STUDY OBJECTIVE: In US emergency departments (EDs), patients with low back pain are often treated with nonsteroidal anti-inflammatory drugs and muscle relaxants. We compare functional outcomes among patients randomized to a 1-week course of naproxen+placebo versus naproxen+orphenadrine or naproxen+methocarbamol. METHODS: This was a randomized, double-blind, comparative effectiveness trial conducted in 2 urban EDs. Patients presenting with acute, nontraumatic, nonradicular low back pain were enrolled...
October 28, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29063827/subcutaneous-injection-of-adalimumab-trial-compared-with-control-sciatic-a-randomised-controlled-trial-of-adalimumab-injection-compared-with-placebo-for-patients-receiving-physiotherapy-treatment-for-sciatica
#12
Nefyn H Williams, Alison Jenkins, Nia Goulden, Zoe Hoare, Dyfrig A Hughes, Eifiona Wood, Nadine E Foster, David A Walsh, Dawn Carnes, Valerie Sparkes, Elaine M Hay, John Isaacs, Kika Konstantinou, Dylan Morrissey, Jaro Karppinen, Stephane Genevay, Clare Wilkinson
BACKGROUND: Biological treatments such as adalimumab (Humira®; AbbVie Ltd, Maidenhead, UK) are antibodies targeting tumour necrosis factor alpha, released from ruptured intervertebral discs, which might be useful in sciatica. Recent systematic reviews concluded that they might be effective, but that a definitive randomised controlled trial was needed. Usual care in the NHS typically includes a physiotherapy intervention. OBJECTIVES: To test whether or not injections of adalimumab plus physiotherapy are more clinically effective and cost-effective than injections of saline plus physiotherapy for patients with sciatica...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29055083/ecosystem-state-shifts-during-long-term-development-of-an-amazonian-peatland
#13
Graeme T Swindles, Paul J Morris, Bronwen Whitney, Jennifer M Galloway, Mariusz Gałka, Angela Gallego-Sala, Andrew L Macumber, Donal Mullan, Mark W Smith, Matthew J Amesbury, Thomas P Roland, Hamed Sanei, R Timothy Patterson, Nicole Sanderson, Lauren Parry, Dan J Charman, Omar Lopez, Elvis Valderamma, Elizabeth J Watson, Ruza F Ivanovic, Paul J Valdes, T Edward Turner, Outi Lähteenoja
The most carbon (C) dense ecosystems of Amazonia are areas characterised by the presence of peatlands. However, Amazonian peatland ecosystems are poorly understood and are threatened by human activities. Here we present an investigation into long-term ecohydrological controls on C accumulation in an Amazonian peat dome. This site is the oldest peatland yet discovered in Amazonia (peat initiation c. 8.9 ka BP), and developed in three stages; (i) peat initiated in an abandoned river channel with open water and aquatic plants; (ii) inundated forest swamp; and (iii) raised peat dome (since c...
October 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29041947/the-fear-reduction-exercised-early-free-approach-to-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#14
Ben Darlow, James Stanley, Sarah Dean, J Haxby Abbott, Sue Garrett, Fiona Mathieson, Anthony Dowell
BACKGROUND: Low back pain (LBP) is a major health issue associated with considerable health loss and societal costs. General practitioners (GPs) play an important role in the management of LBP; however, GP care has not been shown to be the most cost-effective approach unless exercise and behavioural counselling are added to usual care. The Fear Reduction Exercised Early (FREE) approach to LBP has been developed to assist GPs to manage LBP by empowering exploration and management of psychosocial barriers to recovery and provision of evidence-based care and information...
October 17, 2017: Trials
https://www.readbyqxmd.com/read/29037186/comparison-of-serum-markers-for-muscle-damage-surgical-blood-loss-postoperative-recovery-and-surgical-site-pain-after-extreme-lateral-interbody-fusion-with-percutaneous-pedicle-screws-or-traditional-open-posterior-lumbar-interbody-fusion
#15
Tetsuro Ohba, Shigeto Ebata, Hirotaka Haro
BACKGROUND: The benefits of extreme lateral interbody fusion (XLIF) as a minimally invasive lumbar spinal fusion treatment for lumbar degenerative spondylolisthesis have been unclear. We sought to evaluate the invasiveness and tolerability of XLIF with percutaneous pedicle screws (PPS) compared with traditional open posterior lumbar interbody fusion (PLIF). METHODS: Fifty-six consecutive patients underwent open PLIF and 46 consecutive patients underwent single-staged treatment with XLIF with posterior PPS fixation for degenerative lumbar spondylolisthesis, and were followed up for a minimum of 1 year...
October 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29029606/patient-centered-professional-practice-models-for-managing-low-back-pain-in-older-adults-a-pilot-randomized-controlled-trial
#16
Christine M Goertz, Stacie A Salsbury, Cynthia R Long, Robert D Vining, Andrew A Andresen, Maria A Hondras, Kevin J Lyons, Lisa Z Killinger, Fredric D Wolinsky, Robert B Wallace
BACKGROUND: Low back pain is a debilitating condition for older adults, who may seek healthcare from multiple providers. Few studies have evaluated impacts of different healthcare delivery models on back pain outcomes in this population. The purpose of this study was to compare clinical outcomes of older adults receiving back pain treatment under 3 professional practice models that included primary medical care with or without chiropractic care. METHODS: We conducted a pilot randomized controlled trial with 131 community-dwelling, ambulatory older adults with subacute or chronic low back pain...
October 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28994710/large-scale-oral-treatment-study-with-the-four-most-promising-d3-derivatives-for-the-treatment-of-alzheimer-s-disease
#17
Janine Kutzsche, Sarah Schemmert, Markus Tusche, Jörg Neddens, Roland Rabl, Dagmar Jürgens, Oleksandr Brener, Antje Willuweit, Birgit Hutter-Paier, Dieter Willbold
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is associated with the aggregation of the amyloid β protein (Aβ). Aβ oligomers are currently thought to be the major neurotoxic agent responsible for disease development and progression. Thus, their elimination is highly desirable for therapy development. Our therapeutic approach aims at specific and direct elimination of toxic Aβ oligomers by stabilizing Aβ monomers in an aggregation-incompetent conformation. We have proven that our lead compound "D3", an all d-enantiomeric-peptide, specifically eliminates Aβ oligomers in vitro...
October 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28988358/reliability-and-validity-of-the-cross-culturally-adapted-turkish-version-of-the-core-outcome-measures-index-for-low-back-pain
#18
Engin Çetin, Evrim Coşkun Çelik, Emre Acaroğlu, Haluk Berk
PURPOSE: To produce a cross-culturally adapted and validated Turkish version of The Core Outcome Measure Index (COMI) Back questionnaire. METHODS: Ninety-six Turkish-speaking patients with non-specific low back pain (LBP) were recruited from orthopedic and physical therapy outpatient clinics in a public hospital. They completed a booklet of questionnaires containing Turkish version of COMI, adjectival pain scale, Roland Morris disability questionnaire, European 5 Dimension Questionnaire and brief version of World Health Organization Quality of Life Questionnaire...
October 7, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28986339/the-promise-and-pitfalls-of-using-crowdsourcing-in-research-prioritization-for-back-pain-cross-sectional-surveys
#19
Matthew A Bartek, Anjali R Truitt, Sierra Widmer-Rodriguez, Jordan Tuia, Zoya A Bauer, Bryan A Comstock, Todd C Edwards, Sarah O Lawrence, Sarah E Monsell, Donald L Patrick, Jeffrey G Jarvik, Danielle C Lavallee
BACKGROUND: The involvement of patients in research better aligns evidence generation to the gaps that patients themselves face when making decisions about health care. However, obtaining patients' perspectives is challenging. Amazon's Mechanical Turk (MTurk) has gained popularity over the past decade as a crowdsourcing platform to reach large numbers of individuals to perform tasks for a small reward for the respondent, at small cost to the investigator. The appropriateness of such crowdsourcing methods in medical research has yet to be clarified...
October 6, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28984734/a-comparison-of-back-pain-functional-scale-with-roland-morris-disability-questionnaire-oswestry-disability-index-and-short-form-36-health-survey
#20
Meltem Koç, Banu Bayar, Kılıçhan Bayar
STUDY DESIGN: A comparison study of Back Pain Functional Scale (BPFS) with Roland Morris Questionnaire (RMQ), Oswestry Disability Index (ODI) and Short Form 36-Health Survey (SF-36). OBJECTIVE: The aim of this study is to investigate the correlation of BPFS with RMQ, ODI and SF-36. SUMMARY OF BACKGROUND DATA: The primary goal in the treatment of patients with low back pain is to improve the patients' levels of activities and participation...
October 3, 2017: Spine
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