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effect of locomotor training

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https://www.readbyqxmd.com/read/28644923/examining-transfer-effects-of-dual-task-training-protocols-for-a-complex-locomotor-task
#1
Timothy A Worden, Lori Ann Vallis
Training protocols designed to improve dual-task performance of an obstacle crossing and auditory Stroop task (OBS+Stroop) were tested. In Experiment  1 , following baseline collection of OBS+Stroop trials, proximally related walking training was performed, and participants were then retested on the OBS+Stroop test. After training, participants adopted a more cautious obstacle crossing strategy, indicating a potentially safer navigation strategy. Transfer effects from distally related training were then examined (Experiment  2 ); a computer game training paradigm was examined using the same testing protocol as Experiment  1 ...
June 23, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28636434/selective-breeding-and-short-term-access-to-a-running-wheel-alter-stride-characteristics-in-house-mice
#2
Gerald C Claghorn, Zoe Thompson, Jarren C Kay, Genesis Ordonez, Thomas G Hampton, Theodore Garland
Postural and kinematic aspects of running may have evolved to support high runner (HR) mice to run approximately threefold farther than control mice. Mice from four replicate HR lines selectively bred for high levels of voluntary wheel running show many differences in locomotor behavior and morphology as compared with four nonselected control (C) lines. We hypothesized that HR mice would show stride alterations that have coadapted with locomotor behavior, morphology, and physiology. More specifically, we predicted that HR mice would have stride characteristics that differed from those of C mice in ways that parallel some of the adaptations seen in highly cursorial animals...
September 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28628595/activity-based-therapy-from-basic-science-to-clinical-application-for-recovery-after-spinal-cord-injury
#3
Andrea L Behrman, Elizabeth M Ardolino, Susan J Harkema
BACKGROUND AND PURPOSE: Collaboration between scientists and clinicians effectively accelerated translation of scientific evidence for activity-based therapies (ABTs) into rehabilitation. This article addresses the basic scientific findings of activity-dependent plasticity that led to locomotor training, an ABT, and its principles to advance recovery in adult and pediatric populations with spinal cord injury (SCI). Expansion to new therapies based on these common principles is highlighted, for example, epidural stimulation...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28602748/effects-of-physical-exercise-and-social-isolation-on-anxiety-related-behaviors-in-two-inbred-rat-strains
#4
F G Mazur, L F G Oliveira, M P Cunha, A L S Rodrigues, R A N Pértile, L F Vendruscolo, G S Izídio
We investigated the effects of physical exercise (PE) on locomotor activity and anxiety-like behavior in Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) male rats. Rats received either four weeks of forced training, 5days/week, on a treadmill (experiment 1) or were given 21days of free access to running wheels (experiment 2). We also tested the effects of social isolation (SI) (seven days of isolation - experiment 3) on behavior. In experiment 1, 20% of LEW rats and 63% of SHR rats completed the training protocol...
June 8, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28602491/effect-of-visuospatial-neglect-on-spatial-navigation-and-heading-after-stroke
#5
Gayatri Aravind, Anouk Lamontagne
BACKGROUND: Visuospatial neglect (VSN) impairs the control of locomotor heading in post-stroke individuals, which may affect their ability to safely avoid moving objects while walking. OBJECTIVE: We aimed to compare VSN+ and VSN- stroke individuals in terms of changes in heading and head orientation in space while avoiding obstacles approaching from different directions and reorienting toward the final target. METHODS: Stroke participants with VSN (VSN+) and without VSN (VSN-) walked in a virtual environment avoiding obstacles that approached contralesionally, head-on or ipsilesionally...
June 8, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28580370/robotic-assist-as-needed-as-an-alternative-to-therapist-assisted-gait-rehabilitation
#6
Shraddha Srivastava, Pei Chun Kao, Darcy S Reisman, John P Scholz, Sunil K Agrawal, Jill S Higginson
OBJECTIVE: Body Weight Supported Treadmill Training (BWSTT) with therapists' assistance is often used for gait rehabilitation post-stroke. However, this training method is labor-intensive, requiring at least one or as many as three therapists at once for manual assistance. Previously, we demonstrated that providing movement guidance using a performance-based robot-aided gait training (RAGT) that applies a compliant, assist-as-needed force-field improves gait pattern and functional walking ability in people post-stroke...
October 2016: International Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28579351/preclinical-abuse-liability-assessment-of-abt-126-an-agonist-at-the-%C3%AE-7-nicotinic-acetylcholine-receptor-nachr
#7
Thomas J Hudzik, Ana M Basso, James J Lynch, William M Bracken, Eric G Mohler, Kathy L Kohlhaas, Hongyu Xu, George Haig, Laura Gault
ABT-126 is a nicotinic acetylcholine receptor (nAChR) agonist that is selective for the α7 subtype of the receptor. nAChRs are thought to play a role in a variety of neurocognitive processes and have been a pharmacologic target for disorders with cognitive impairment, including schizophrenia and Alzheimer's disease. As part of the preclinical safety package for ABT-126, its potential for abuse was assessed. While the involvement of the α4β2 subtype of the nicotinic receptor in the addictive properties of nicotine has been demonstrated, the role of the α7 receptor has been studied much less extensively...
July 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28576629/robotic-resistance-treadmill-training-improves-locomotor-function-in-children-with-cerebral-palsy-a-randomized-controlled-pilot-study
#8
Ming Wu, Janis Kim, Deborah J Gaebler-Spira, Brian D Schmit, Pooja Arora
OBJECTIVE: To determine whether applying controlled resistance forces to the legs during the swing phase of gait may improve the efficacy of treadmill training compared to applying controlled assistance forces in children with cerebral palsy (CP). DESIGN: Randomized controlled study. SETTING: Research unit of rehabilitation hospital. PARTICIPANTS: Children with spastic CP (n = 23, average age 10.6 years old, ranged from 6-14, GMFCS levels: I to IV)...
May 30, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28575558/-model-ontogenetic-variability-functional-state-of-the-organism-in-different-modes-of-motor-activity
#9
V V Myakotnyh, L S Khodasevich
The analysis of the study results of remote training effect of physical training and sports in the age range including the later periods of human ontogenesis, from the point of oxidative stress theory. To study the characteristics of developmental variability of the functional state of the organism, a comparative study of the functional state of the body at different modes of physical activity in different age stages of development was carried out: from sports veterans, remain actively locomotor activity after the termination of sports career; former athletes, leading a sedentary lifestyle; persons engaged in improving the forms of physical exercise; as well as persons who had not engaged in regular physical activity...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28575054/hemorrhagic-versus-ischemic-stroke-who-can-best-benefit-from-blended-conventional-physiotherapy-with-robotic-assisted-gait-therapy
#10
Frédéric Dierick, Mélanie Dehas, Jean-Luc Isambert, Soizic Injeyan, Anne-France Bouché, Yannick Bleyenheuft, Sigal Portnoy
BACKGROUND: Contrary to common belief of clinicians that hemorrhagic stroke survivors have better functional prognoses than ischemic, recent studies show that ischemic survivors could experience similar or even better functional improvements. However, the influence of stroke subtype on gait and posture outcomes following an intervention blending conventional physiotherapy with robotic-assisted gait therapy is missing. OBJECTIVE: This study compared gait and posture outcome measures between ambulatory hemorrhagic patients and ischemic patients, who received a similar 4 weeks' intervention blending a conventional bottom-up physiotherapy approach and an exoskeleton top-down robotic-assisted gait training (RAGT) approach with Lokomat...
2017: PloS One
https://www.readbyqxmd.com/read/28537942/locomotor-and-discriminative-stimulus-effects-of-four-novel-hallucinogens-in-rodents
#11
Michael B Gatch, Sean B Dolan, Michael J Forster
There has been increasing use of novel synthetic hallucinogenic compounds, 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25B-NBOMe), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25C-NBOMe), 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25I-NBOMe), and N,N-diallyl-5-methoxy tryptamine (5-MeO-DALT), which have been associated with severe toxicities. These four compounds were tested for discriminative stimulus effects similar to a prototypical hallucinogen (-)-2,5-dimethoxy-4-methylamphetamine (DOM) and the entactogen (±)-3,4-methylenedioxymethamphetamine (MDMA)...
May 30, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28494321/objective-assessment-of-movement-competence-in-children-using-wearable-sensors-an-instrumented-version-of-the-tgmd-2-locomotor-subtest
#12
Maria Cristina Bisi, G Pacini Panebianco, R Polman, R Stagni
Movement competence (MC) is defined as the development of sufficient skill to assure successful performance in different physical activities. Monitoring children MC during maturation is fundamental to detect early minor delays and define effective intervention. To this purpose, several MC assessment batteries are available. When evaluating movement strategies, with the aim of identifying specific skill components that may need improving, widespread MC assessment is limited by high time consumption for scoring and the need for trained operators to ensure reliability...
July 2017: Gait & Posture
https://www.readbyqxmd.com/read/28487067/selective-and-interactive-effects-of-d2-receptor-antagonism-and-positive-allosteric-mglur4-modulation-on-waiting-impulsivity
#13
Sarah N Isherwood, Trevor W Robbins, Janet R Nicholson, Jeffrey W Dalley, Anton Pekcec
BACKGROUND: Metabotropic glutamate receptor 4 (mGluR4) and dopamine D2 receptors are specifically expressed within the indirect pathway neurons of the striato-pallidal-subthalamic pathway. This unique expression profile suggests that mGluR4 and D2 receptors may play a cooperative role in the regulation and inhibitory control of behaviour. We investigated this possibility by testing the effects of a functionally-characterised positive allosteric mGluR4 modulator, 4-((E)-styryl)-pyrimidin-2-ylamine (Cpd11), both alone and in combination with the D2 receptor antagonist eticlopride, on two distinct forms of impulsivity...
May 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28482762/power-training-in-chronic-stroke-individuals-differences-between-responders-and-nonresponders
#14
Stacey E Aaron, Jennifer L Hunnicutt, Aaron E Embry, Mark G Bowden, Chris M Gregory
BACKGROUND: Lower extremity muscle weakness is a primary contributor to post-stroke dysfunction. Resistance training is an effective treatment for hemiparetic weakness and improves walking performance. Post-stroke subject characteristics that do or do not improve walking speed following resistance training are unknown. OBJECTIVE: The purpose of this paper was to describe baseline characteristics, as well as responses to training, associated with achieving a minimal clinically important difference (MCID) in walking speed (≥0...
May 8, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28462472/role-of-the-agranular-insular-cortex-in-contextual-control-over-cocaine-seeking-behavior-in-rats
#15
Amy A Arguello, Rong Wang, Carey M Lyons, Jessica A Higginbotham, Matthew A Hodges, Rita A Fuchs
RATIONALE: Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. OBJECTIVES: The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine memory reconsolidation...
May 2, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28435743/effects-of-overground-locomotor-training-on-the-ventilatory-response-to-volitional-treadmill-walking-in-individuals-with-incomplete-spinal-cord-injury-a-pilot-study
#16
Gino S Panza, Andrew A Guccione, Lisa M Chin, Jared M Gollie, Jeffery E Herrick, John P Collins
INTRODUCTION: Although there has been substantial emphasis on the neuromuscular and cardiovascular adaptations following rehabilitation, pulmonary adaptations in individuals with incomplete SCI (iSCI) in response to locomotor training have been less frequently studied. In healthy individuals, effective transition from rest to work is accomplished by a hyperpneic response, which exhibits an exponential curve with three phases. However, the degree to which our current understanding of exercise hyperpnea can be applied to individuals with iSCI is unknown...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28412304/synergistic-effect-between-d-ap5-and-muscimol-in-the-nucleus-accumbens-shell-on-memory-consolidation-deficit-in-adult-male-wistar-rats-an-isobologram-analysis
#17
Mohammad Nasehi, Elaheh Ostadi, Fatemeh Khakpai, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast
The nucleus accumbens (NAc) glutamatergic and GABAergic systems are involved in memory processes. This study was investigated the involvement of NAc shell GABAergic system on D-AP5 induced memory consolidation deficit. The elevated plus-maze (EPM) test-retest paradigm was employed to assess memory in adult male Wistar rats. The results indicated that post-training intra-NAc shell injection of bicuculline (GABAA receptor antagonist) did not alter emotional memory consolidation. However, post-training intra-NAc shell microinjection of muscimol (GABAA receptor agonist, 0...
April 12, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28399873/influence-of-functional-task-oriented-mental-practice-on-the-gait-of-transtibial-amputees-a-randomized-clinical-trial
#18
Rodrigo Gontijo Cunha, Paulo José Guimarães Da-Silva, Clarissa Cardoso Dos Santos Couto Paz, Ana Carolina da Silva Ferreira, Carlos Julio Tierra-Criollo
BACKGROUND: Mental practice (MP) through motor imagery is a cognitive training strategy used to improve locomotor skills during rehabilitation programs. Recent works have used MP tasks to investigate the neurophysiology of human gait; however, its effect on functional performance has not been evaluated. In the present study, the influence of gait-oriented MP tasks on the rehabilitation process of gait in transtibial amputees was investigated by assessing the vertical (V), anterior-posterior (AP), and medio-lateral (ML) ground reaction forces (GRFs) and the time duration of the support phase of the prosthetic limb...
April 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28389208/role-of-the-amygdala-gaba-a-receptors-in-acpa-induced-deficits-during-conditioned-fear-learning
#19
Mohammad Nasehi, Farnaz Roghani, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast
The basolateral amygdala (BLA) is a key structure for the emotional processing and storage of memories associated with emotional events, especially fear. On the other hand, endocannabinoids and CB1 receptors play a key role in learning and memory partly through long-term synaptic depression of GABAergic synapses in the BLA. The aim of this study was to explore the effects of GABA-A receptor agonist and antagonist in the fear-related memory acquisition deficits induced by ACPA (a selective CB1 cannabinoid receptor agonist)...
April 4, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28387692/the-role-of-sensory-augmentation-for-people-with-vestibular-deficits-real-time-balance-aid-and-or-rehabilitation-device
#20
K H Sienko, S L Whitney, W J Carender, C Wall
This narrative review highlights findings from the sensory augmentation field for people with vestibular deficits and addresses the outstanding questions that are critical to the translation of this technology into clinical and/or personal use. Prior research has demonstrated that the real-time use of visual, vibrotactile, auditory, and multimodal sensory augmentation technologies can improve balance during static and dynamic stance tasks within a laboratory setting. However, its application in improving gait requires additional investigation, as does its efficacy as a rehabilitation device for people with vestibular deficits...
2017: Journal of Vestibular Research: Equilibrium & Orientation
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