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effect of locomotor training

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https://www.readbyqxmd.com/read/28727643/improving-early-adolescent-girls-motor-skill-a-cluster-randomized-controlled-trial
#1
Natalie Lander, Philip J Morgan, Jo Salmon, Lisa M Barnett
BACKGROUND: Physical activity (PA) levels decline substantially during adolescence, and are consistently lower in girls. Competency in a range of fundamental movement skills (FMS) may serve as a protective factor for the decline in PA typically observed in adolescent girls; yet, girls' mastery in FMS is low. Whilst interventions can improve FMS, there is a lack of interventions targeting girls, and very few are conducted in high schools. Additionally, interventions are usually conducted by researchers, not teachers, and thus have little chance of being embedded into curricula...
July 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28724382/activation-of-cannabinoid-receptor-type-2-attenuates-surgery-induced-cognitive-impairment-in-mice-through-anti-inflammatory-activity
#2
Lingling Sun, Rui Dong, Xin Xu, Xi Yang, Mian Peng
BACKGROUND: Neuroinflammation plays a major role in postoperative cognitive dysfunction (POCD). Accumulated evidence indicates that cannabinoid receptor type 2 (CB2R) can mediate anti-inflammatory and immunomodulatory effects in part by controlling microglial activity. However, the impact of CB2R on postoperative cognition has not been investigated. We hypothesized that CB2R is involved in surgery-induced cognitive impairment in adult mice. METHODS: Adult C57BL/6 mice were subjected to intramedullary fixation surgery for tibial fracture under isoflurane anesthesia and CB2R agonist (JWH133) or CB2R antagonist (AM630) treatment...
July 19, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28716590/lumbar-muscle-inflammation-alters-spinally-mediated-locomotor-recovery-induced-by-training-in-a-mouse-model-of-complete-spinal-cord-injury
#3
Renaud Jeffrey-Gauthier, Mathieu Piché, Hugues Leblond
Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion recovery in a mouse model of complete SCI. Lower limb kinematics during treadmill training was assessed before and after complete SCI at T8 (2, 7, 14, 21 and 28 days post-injury). Locomotor recovery was compared in 4 groups of CD1 mice: control spinal mice; spinal mice with daily locomotor training; spinal mice with lumbar muscle inflammation (Complete Freund's Adjuvant (CFA) injection); and spinal mice with locomotor training and CFA...
July 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28691601/task-specific-and-functional-effects-of-speed-focused-elliptical-or-motor-assisted-cycle-training-in-children-with-bilateral-cerebral-palsy-randomized-clinical-trial
#4
Diane L Damiano, Christopher J Stanley, Laurie Ohlrich, Katharine E Alter
BACKGROUND: Locomotor training using treadmills or robotic devices is commonly utilized to improve gait in cerebral palsy (CP); however, effects are inconsistent and fail to exceed those of equally intense alternatives. Possible limitations of existing devices include fixed nonvariable rhythm and too much limb or body weight assistance. OBJECTIVE: To quantify and compare effectiveness of a motor-assisted cycle and a novel alternative, an elliptical, in CP to improve interlimb reciprocal coordination through intensive speed-focused leg training...
July 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28676750/multi-trial-gait-adaptation-of-healthy-individuals-during-visual-kinematic-perturbations
#5
Trieu Phat Luu, Yongtian He, Sho Nakagome, Kevin Nathan, Samuel Brown, Jeffrey Gorges, Jose L Contreras-Vidal
Optimizing rehabilitation strategies requires understanding the effects of contextual cues on adaptation learning. Prior studies have examined these effects on the specificity of split-belt walking adaptation, showing that contextual visual cues can be manipulated to modulate the magnitude, transfer, and washout of split-belt-induced learning in humans. Specifically, manipulating the availability of vision during training or testing phases of learning resulted in differences in adaptive mechanisms for temporal and spatial features of walking...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28644923/examining-transfer-effects-of-dual-task-training-protocols-for-a-complex-locomotor-task
#6
Timothy A Worden, Lori Ann Vallis
Training protocols designed to improve dual-task performance of an obstacle crossing and auditory Stroop task (OBS+Stroop) were tested. In Experiment  1 , following baseline collection of OBS+Stroop trials, proximally related walking training was performed, and participants were then retested on the OBS+Stroop test. After training, participants adopted a more cautious obstacle crossing strategy, indicating a potentially safer navigation strategy. Transfer effects from distally related training were then examined (Experiment  2 ); a computer game training paradigm was examined using the same testing protocol as Experiment  1 ...
June 23, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28636434/selective-breeding-and-short-term-access-to-a-running-wheel-alter-stride-characteristics-in-house-mice
#7
Gerald C Claghorn, Zoe Thompson, Jarren C Kay, Genesis Ordonez, Thomas G Hampton, Theodore Garland
Postural and kinematic aspects of running may have evolved to support high runner (HR) mice to run approximately threefold farther than control mice. Mice from four replicate HR lines selectively bred for high levels of voluntary wheel running show many differences in locomotor behavior and morphology as compared with four nonselected control (C) lines. We hypothesized that HR mice would show stride alterations that have coadapted with locomotor behavior, morphology, and physiology. More specifically, we predicted that HR mice would have stride characteristics that differed from those of C mice in ways that parallel some of the adaptations seen in highly cursorial animals...
September 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28628595/activity-based-therapy-from-basic-science-to-clinical-application-for-recovery-after-spinal-cord-injury
#8
Andrea L Behrman, Elizabeth M Ardolino, Susan J Harkema
BACKGROUND AND PURPOSE: Collaboration between scientists and clinicians effectively accelerated translation of scientific evidence for activity-based therapies (ABTs) into rehabilitation. This article addresses the basic scientific findings of activity-dependent plasticity that led to locomotor training, an ABT, and its principles to advance recovery in adult and pediatric populations with spinal cord injury (SCI). Expansion to new therapies based on these common principles is highlighted, for example, epidural stimulation...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28602748/effects-of-physical-exercise-and-social-isolation-on-anxiety-related-behaviors-in-two-inbred-rat-strains
#9
F G Mazur, L F G Oliveira, M P Cunha, A L S Rodrigues, R A N Pértile, L F Vendruscolo, G S Izídio
We investigated the effects of physical exercise (PE) on locomotor activity and anxiety-like behavior in Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) male rats. Rats received either four weeks of forced training, 5days/week, on a treadmill (experiment 1) or were given 21days of free access to running wheels (experiment 2). We also tested the effects of social isolation (SI) (seven days of isolation - experiment 3) on behavior. In experiment 1, 20% of LEW rats and 63% of SHR rats completed the training protocol...
June 8, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28602491/effect-of-visuospatial-neglect-on-spatial-navigation-and-heading-after-stroke
#10
Gayatri Aravind, Anouk Lamontagne
BACKGROUND: Visuospatial neglect (VSN) impairs the control of locomotor heading in post-stroke individuals, which may affect their ability to safely avoid moving objects while walking. OBJECTIVE: We aimed to compare VSN+ and VSN- stroke individuals in terms of changes in heading and head orientation in space while avoiding obstacles approaching from different directions and reorienting toward the final target. METHODS: Stroke participants with VSN (VSN+) and without VSN (VSN-) walked in a virtual environment avoiding obstacles that approached contralesionally, head-on or ipsilesionally...
June 8, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28580370/robotic-assist-as-needed-as-an-alternative-to-therapist-assisted-gait-rehabilitation
#11
Shraddha Srivastava, Pei Chun Kao, Darcy S Reisman, John P Scholz, Sunil K Agrawal, Jill S Higginson
OBJECTIVE: Body Weight Supported Treadmill Training (BWSTT) with therapists' assistance is often used for gait rehabilitation post-stroke. However, this training method is labor-intensive, requiring at least one or as many as three therapists at once for manual assistance. Previously, we demonstrated that providing movement guidance using a performance-based robot-aided gait training (RAGT) that applies a compliant, assist-as-needed force-field improves gait pattern and functional walking ability in people post-stroke...
October 2016: International Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28579351/preclinical-abuse-liability-assessment-of-abt-126-an-agonist-at-the-%C3%AE-7-nicotinic-acetylcholine-receptor-nachr
#12
Thomas J Hudzik, Ana M Basso, James J Lynch, William M Bracken, Eric G Mohler, Kathy L Kohlhaas, Hongyu Xu, George Haig, Laura Gault
ABT-126 is a nicotinic acetylcholine receptor (nAChR) agonist that is selective for the α7 subtype of the receptor. nAChRs are thought to play a role in a variety of neurocognitive processes and have been a pharmacologic target for disorders with cognitive impairment, including schizophrenia and Alzheimer's disease. As part of the preclinical safety package for ABT-126, its potential for abuse was assessed. While the involvement of the α4β2 subtype of the nicotinic receptor in the addictive properties of nicotine has been demonstrated, the role of the α7 receptor has been studied much less extensively...
July 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28576629/robotic-resistance-treadmill-training-improves-locomotor-function-in-children-with-cerebral-palsy-a-randomized-controlled-pilot-study
#13
Ming Wu, Janis Kim, Deborah J Gaebler-Spira, Brian D Schmit, Pooja Arora
OBJECTIVE: To determine whether applying controlled resistance forces to the legs during the swing phase of gait may improve the efficacy of treadmill training as compared with applying controlled assistance forces in children with cerebral palsy (CP). DESIGN: Randomized controlled study. SETTING: Research unit of a rehabilitation hospital. PARTICIPANTS: Children with spastic CP (N=23; mean age, 10.6y; range, 6-14y; Gross Motor Function Classification System levels, I-IV)...
May 30, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28575558/-model-ontogenetic-variability-functional-state-of-the-organism-in-different-modes-of-motor-activity
#14
V V Myakotnyh, L S Khodasevich
The analysis of the study results of remote training effect of physical training and sports in the age range including the later periods of human ontogenesis, from the point of oxidative stress theory. To study the characteristics of developmental variability of the functional state of the organism, a comparative study of the functional state of the body at different modes of physical activity in different age stages of development was carried out: from sports veterans, remain actively locomotor activity after the termination of sports career; former athletes, leading a sedentary lifestyle; persons engaged in improving the forms of physical exercise; as well as persons who had not engaged in regular physical activity...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28575054/hemorrhagic-versus-ischemic-stroke-who-can-best-benefit-from-blended-conventional-physiotherapy-with-robotic-assisted-gait-therapy
#15
Frédéric Dierick, Mélanie Dehas, Jean-Luc Isambert, Soizic Injeyan, Anne-France Bouché, Yannick Bleyenheuft, Sigal Portnoy
BACKGROUND: Contrary to common belief of clinicians that hemorrhagic stroke survivors have better functional prognoses than ischemic, recent studies show that ischemic survivors could experience similar or even better functional improvements. However, the influence of stroke subtype on gait and posture outcomes following an intervention blending conventional physiotherapy with robotic-assisted gait therapy is missing. OBJECTIVE: This study compared gait and posture outcome measures between ambulatory hemorrhagic patients and ischemic patients, who received a similar 4 weeks' intervention blending a conventional bottom-up physiotherapy approach and an exoskeleton top-down robotic-assisted gait training (RAGT) approach with Lokomat...
2017: PloS One
https://www.readbyqxmd.com/read/28537942/locomotor-and-discriminative-stimulus-effects-of-four-novel-hallucinogens-in-rodents
#16
Michael B Gatch, Sean B Dolan, Michael J Forster
There has been increasing use of novel synthetic hallucinogenic compounds, 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25B-NBOMe), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25C-NBOMe), 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25I-NBOMe), and N,N-diallyl-5-methoxy tryptamine (5-MeO-DALT), which have been associated with severe toxicities. These four compounds were tested for discriminative stimulus effects similar to a prototypical hallucinogen (-)-2,5-dimethoxy-4-methylamphetamine (DOM) and the entactogen (±)-3,4-methylenedioxymethamphetamine (MDMA)...
August 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28494321/objective-assessment-of-movement-competence-in-children-using-wearable-sensors-an-instrumented-version-of-the-tgmd-2-locomotor-subtest
#17
Maria Cristina Bisi, G Pacini Panebianco, R Polman, R Stagni
Movement competence (MC) is defined as the development of sufficient skill to assure successful performance in different physical activities. Monitoring children MC during maturation is fundamental to detect early minor delays and define effective intervention. To this purpose, several MC assessment batteries are available. When evaluating movement strategies, with the aim of identifying specific skill components that may need improving, widespread MC assessment is limited by high time consumption for scoring and the need for trained operators to ensure reliability...
July 2017: Gait & Posture
https://www.readbyqxmd.com/read/28487067/selective-and-interactive-effects-of-d2-receptor-antagonism-and-positive-allosteric-mglur4-modulation-on-waiting-impulsivity
#18
Sarah N Isherwood, Trevor W Robbins, Janet R Nicholson, Jeffrey W Dalley, Anton Pekcec
BACKGROUND: Metabotropic glutamate receptor 4 (mGluR4) and dopamine D2 receptors are specifically expressed within the indirect pathway neurons of the striato-pallidal-subthalamic pathway. This unique expression profile suggests that mGluR4 and D2 receptors may play a cooperative role in the regulation and inhibitory control of behaviour. We investigated this possibility by testing the effects of a functionally-characterised positive allosteric mGluR4 modulator, 4-((E)-styryl)-pyrimidin-2-ylamine (Cpd11), both alone and in combination with the D2 receptor antagonist eticlopride, on two distinct forms of impulsivity...
May 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28482762/power-training-in-chronic-stroke-individuals-differences-between-responders-and-nonresponders
#19
Stacey E Aaron, Jennifer L Hunnicutt, Aaron E Embry, Mark G Bowden, Chris M Gregory
BACKGROUND: Lower extremity muscle weakness is a primary contributor to post-stroke dysfunction. Resistance training is an effective treatment for hemiparetic weakness and improves walking performance. Post-stroke subject characteristics that do or do not improve walking speed following resistance training are unknown. OBJECTIVE: The purpose of this paper was to describe baseline characteristics, as well as responses to training, associated with achieving a minimal clinically important difference (MCID) in walking speed (≥0...
May 8, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28462472/role-of-the-agranular-insular-cortex-in-contextual-control-over-cocaine-seeking-behavior-in-rats
#20
Amy A Arguello, Rong Wang, Carey M Lyons, Jessica A Higginbotham, Matthew A Hodges, Rita A Fuchs
RATIONALE: Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. OBJECTIVES: The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine memory reconsolidation...
May 2, 2017: Psychopharmacology
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