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effect of locomotor training

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https://www.readbyqxmd.com/read/29164023/type-and-timing-of-rehabilitation-following-acute-and-subacute-spinal-cord-injury-a-systematic-review
#1
REVIEW
Anthony S Burns, Ralph J Marino, Sukhvinder Kalsi-Ryan, James W Middleton, Lindsay A Tetreault, Joseph R Dettori, Kathryn E Mihalovich, Michael G Fehlings
Objectives: The objective of this study was to conduct a systematic review of the literature to address the following clinical questions: In adult patients with acute and subacute complete or incomplete traumatic SCI, (1) does the time interval between injury and commencing rehabilitation affect outcome?; (2) what is the comparative effectiveness of different rehabilitation strategies, including different intensities and durations of treatment?; (3) are there patient or injury characteristics that affect the efficacy of rehabilitation?; and (4) what is the cost-effectiveness of various rehabilitation strategies? Methods: A systematic search was conducted for literature published through March 31, 2015 that evaluated rehabilitation strategies in adults with acute or subacute traumatic SCI at any level...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29156378/effect-of-robotic-assisted-gait-rehabilitation-on-dynamic-equilibrium-control-in-the-gait-of-children-with-cerebral-palsy
#2
L Wallard, G Dietrich, Y Kerlirzin, J Bredin
Due to the intensity and repetition of movement, roboticassisted gait training therapy could have a beneficial effect on the recovery and improvement of postural and locomotor functions of the patient. This study sought to highlight the effects of robotic-assisted gait rehabilitation in gait of children with Cerebral Palsy (CP). We analyzed the different strategies before and after this rehabilitation which was used in order to generate forward motion while maintaining balance. Data were collected by a motion analysis system (Vicon® - Oxford Metrics, Oxford, UK)...
November 11, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29136766/behavioral-and-biochemical-evidences-for-nootropic-activity-of-boldine-in-young-and-aged-mice
#3
Dinesh Dhingra, Kapil Soni
Boldine, a bioactive compound, has been reported to be neuroprotective, but its effect on learning and memory has not been explored. So, the present study was aimed to study the effect of boldine on the learning and memory of the Swiss albino male young and aged mice. Boldine (1.5, 3 and 6mg/kg, po) and physostigmine salicylate (0.1mg/kg, ip) were administered to separate groups of mice for 7 successive days. Morris water maze was utilized as a behavioural model to study the effect of drugs on learning and memory of mice...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29128872/prenatal-kynurenine-treatment-in-rats-causes-schizophrenia-like-broad-monitoring-deficits-in-adulthood
#4
Britta Hahn, Carolyn H Reneski, Ana Pocivavsek, Robert Schwarcz
RATIONALE: Elevated brain kynurenic acid (KYNA) levels are implicated in the pathology and neurodevelopmental pathogenesis of schizophrenia. In rats, embryonic treatment with kynurenine (EKyn) causes elevated brain KYNA levels in adulthood and cognitive deficits reminiscent of schizophrenia. OBJECTIVES: Growing evidence suggests that people with schizophrenia have a narrowed attentional focus, and we aimed at establishing whether these abnormalities may be related to KYNA dysregulation...
November 11, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29117189/cardiac-cycle-synchronized-electrical-muscle-stimulator-for-lower-limb-training-with-the-potential-to-reduce-the-heart-s-pumping-workload
#5
Ken-Ichiro Sasaki, Hiroo Matsuse, Ryuji Akimoto, Shiro Kamiya, Toshio Moritani, Motoki Sasaki, Yuta Ishizaki, Masanori Ohtsuka, Takaharu Nakayoshi, Takafumi Ueno, Naoto Shiba, Yoshihiro Fukumoto
BACKGROUND: The lower limb muscle may play an important role in decreasing the heart's pumping workload. Aging and inactivity cause atrophy and weakness of the muscle, leading to a loss of the heart-assisting role. An electrical lower limb muscle stimulator can prevent atrophy and weakness more effectively than conventional resistance training; however, it has been reported to increase the heart's pumping workload in some situations. Therefore, more effective tools should be developed...
2017: PloS One
https://www.readbyqxmd.com/read/29111178/dose-dependent-neurocognitive-deficits-following-postnatal-day-10-hiv-1-viral-protein-exposure-relationship-to-hippocampal-anatomy-parameters
#6
Sylvia Fitting, Kristen A McLaurin, Rosemarie M Booze, Charles F Mactutus
Despite the availability of antiretroviral prophylactic treatment, pediatric human immunodeficiency virus type 1 (HIV-1) continues to be a significant risk factor in the post-cART era. The time of infection (i.e., during pregnancy, delivery or breastfeeding) may play a role in the development of neurocognitive deficits in pediatric HIV-1. HIV-1 viral protein exposure on postnatal day (P)1, preceding the postnatal brain growth spurt in rats, had deleterious effects on neurocognitive development and anatomical parameters of the hippocampus (Fitting et al...
October 27, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29102966/effects-of-scalp-electroacupuncture-on-the-pi3k-akt-signalling-pathway-and-apoptosis-of-hippocampal-neurons-in-a-rat-model-of-cerebral-palsy
#7
Hanhong Zhang, Jing Gao, Mengmeng Wang, Xuefeng Yu, Xiuhua Lv, Huan Deng, Xiangwei Fan, Kaiyun Chen
Background Substantial evidence from clinical reports has established that most cerebral palsy (CP) patients benefit from a comprehensive rehabilitation exercise training programme. Such advances are enhanced when scalp electroacupuncture (EA), applied at a location corresponding to the projection of the motor area, is combined with rehabilitation exercise training. However, little information exists regarding the mechanistic basis for these effects.Objective To examine whether EA stimulation within the scalp projection location of the motor area can inhibit apoptosis of hippocampal neurons by regulating the PI3k/Akt signalling pathway in a rat model of CP...
November 4, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29081250/effects-of-training-intensity-on-locomotor-performance-in-individuals-with-chronic-spinal-cord-injury-a-randomized-crossover-study
#8
Gabrielle Brazg, Meghan Fahey, Carey L Holleran, Mark Connolly, Jane Woodward, Patrick W Hennessy, Brian D Schmit, T George Hornby
BACKGROUND: Many physical interventions can improve locomotor function in individuals with motor incomplete spinal cord injury (iSCI), although the training parameters that maximize recovery are not clear. Previous studies in individuals with other neurologic injuries suggest the intensity of locomotor training (LT) may positively influence walking outcomes. However, the effects of intensity during training of individuals with iSCI have not been tested. OBJECTIVE: The purpose of this pilot, blinded-assessor randomized trial was to evaluate the effects of LT intensity on walking outcomes in individuals with iSCI...
October 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29077960/locomotor-training-and-strength-and-balance-exercises-for-walking-recovery-after-stroke-response-to-number-of-training-sessions
#9
RANDOMIZED CONTROLLED TRIAL
Dorian K Rose, Stephen E Nadeau, Samuel S Wu, Julie K Tilson, Bruce H Dobkin, Qinglin Pei, Pamela W Duncan
Background: Evidence-based guidelines are needed to inform rehabilitation practice, including the effect of number of exercise training sessions on recovery of walking ability after stroke. Objective: The objective of this study was to determine the response to increasing number of training sessions of 2 interventions-locomotor training and strength and balance exercises-on poststroke walking recovery. Design: This is a secondary analysis of the Locomotor Experience Applied Post-Stroke (LEAPS) randomized controlled trial...
November 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29060079/the-impact-of-an-anti-gravity-treadmill-alterg-training-on-walking-capacity-and-corticospinal-tract-structure-in-children-with-cerebral-palsy
#10
Sh Azizi, H Marzbani, S Raminfard, P M Birgani, A H Rasooli, M M Mirbagheri
We studied the effects of an anti-gravity treadmill (AlterG) training on walking capacity and corticospinal tract structure in children with Cerebral Palsy (CP). AlterG can help CP children walk on the treadmill by reducing their weights up to 80% and maintain their balance during locomotion. AlterG training thus has the potential to improve walking capacity permanently as it can provide systematic and intense locomotor training for sufficiently long period of time and produce brain neuroplasticity. AlterG training was given for 45 minutes, three times a week for two months...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29048920/different-role-of-ca1-5ht3-serotonin-receptors-on-memory-acquisition-deficit-induced-by-total-tsd-and-rem-sleep-deprivation-rsd
#11
Zainab Eydipour, Gholamhassan Vaezi, Mohammad Nasehi, Seyed-Ali Haeri-Rouhani, Mohammad-Reza Zarrindast
BACKGROUND: Serotonin receptors such as 5-HT3 plays critical role in regulation of sleep, wake cycle and cognitive process. Thus, we investigated the role of CA1 5HT3 serotonin receptors in memory acquisition deficit induced by total sleep deprivation (TSD; for 24 hour) and REM sleep deprivation (RSD; for 24 hour). Pain perception and locomotor activity were also assessed as factors that may affect the memory process. METHODS: Modified water box and multi-platform apparatus were used to induce TSD or RSD, respectively...
September 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29040224/fes-assisted-cycling-improves-aerobic-capacity-and-locomotor-function-post-cva
#12
Stacey E Aaron, Catherine J VanDerwerker, Aaron E Embry, Jennifer H Newton, Samuel C K Lee, Chris M Gregory
PURPOSE: After a cerebrovascular accident (CVA) aerobic deconditioning contributes to diminished physical function. Functional Electrical Stimulation (FES)-assisted cycling is a promising exercise paradigm designed to target both aerobic capacity and locomotor function. This pilot study aimed to evaluate the effects of an FES-assisted cycling intervention on aerobic capacity and locomotor function in individuals post-CVA. METHODS: Eleven individuals with chronic (> 6 months) post-CVA hemiparesis completed an 8-week (3x/wk; 24 sessions) progressive FES-assisted cycling intervention...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29021739/effect-of-error-augmentation-on-brain-activation-and-motor-learning-of-a-complex-locomotor-task
#13
Laura Marchal-Crespo, Lars Michels, Lukas Jaeger, Jorge López-Olóriz, Robert Riener
Up to date, the functional gains obtained after robot-aided gait rehabilitation training are limited. Error augmenting strategies have a great potential to enhance motor learning of simple motor tasks. However, little is known about the effect of these error modulating strategies on complex tasks, such as relearning to walk after a neurologic accident. Additionally, neuroimaging evaluation of brain regions involved in learning processes could provide valuable information on behavioral outcomes. We investigated the effect of robotic training strategies that augment errors-error amplification and random force disturbance-and training without perturbations on brain activation and motor learning of a complex locomotor task...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28970972/an-exploration-of-strategies-used-by-dressage-horses-to-control-moments-around-the-center-of-mass-when-performing-passage
#14
Hilary M Clayton, Sarah Jane Hobbs
BACKGROUND: Locomotion results from the generation of ground reaction forces (GRF) that cause translations of the center of mass (COM) and generate moments that rotate the body around the COM. The trot is a diagonally-synchronized gait performed by horses at intermediate locomotor speeds. Passage is a variant of the trot performed by highly-trained dressage horses. It is distinguished from trot by having a slow speed of progression combined with great animation of the limbs in the swing phase...
2017: PeerJ
https://www.readbyqxmd.com/read/28952828/locomotor-and-heart-rate-responses-of-floaters-during-small-sided-games-in-elite-soccer-players-effect-of-pitch-size-and-inclusion-of-goal-keepers
#15
Mathieu Lacome, Ben M Simpson, Yannick Cholley, Martin Buchheit
PURPOSE: To (1) compare the locomotor and heart rate responses between floaters and regular players during both small and large small sided games (SSGs) and (2) examine whether the type of game (i.e., game simulation vs possession game) affects the magnitude of the difference between floaters and regular players. METHODS: Data were collected in 41 players belonging to an elite French football team during three consecutive seasons (2014-2017). 5-Hz GPS were used to collect all training data, with the Athletic Data Innovation analyser (v5...
September 27, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28944642/variability-of-gps-derived-running-performance-during-official-matches-in-elite-professional-soccer-players
#16
Hani Al Haddad, Alberto Méndez-Villanueva, Nacho Torreño, Diego Munguía-Izquierdo, Luis Suárez-Arrones
AIM: The aim of this study was to assess the match-to-match variability obtained using GPS devices, collected during official games in professional soccer players. METHODS: GPS-derived data from nineteen elite soccer players were collected over two consecutive seasons. Time-motion data for players with more than five full-match were analyzed (n=202). Total distance covered (TD), TD >13-18 km/h, TD >18-21 km/h, TD >21 km/h, number of acceleration >2.5-4 m...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28885007/stereoselective-differences-between-the-reinforcing-and-motivational-effects-of-cathinone-derived-4-methylmethcathinone-mephedrone-in-self-administering-rats
#17
Helene L Philogene-Khalid, Steven J Simmons, Sunil Nayak, Rose M Martorana, Shu H Su, Yohanka Caro, Brona Ranieri, Kathryn DiFurio, Lili Mo, Taylor A Gentile, Ali Murad, Allen B Reitz, John W Muschamp, Scott M Rawls
Mephedrone (4-methylmethcathinone (4-MMC)) (MEPH) is a new psychoactive substance (NPS) of the synthetic cathinone class. MEPH has a chiral center and exists as two enantiomers (R-,S-MEPH), yet stereospecific effects of MEPH have not been extensively investigated in preclinical assays. Because significant behavioral and neurochemical differences can exist between enantiomers, probing effects of stereochemistry on biological activity enables separation of adverse and therapeutic effects. Our prior work showed that R-MEPH, relative to S-MEPH, produced greater locomotor activation, place preference, and facilitation of brain reward thresholds in rodents...
September 22, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28882561/locomotor-and-reinforcing-effects-of-pentedrone-pentylone-and-methylone-in-rats
#18
Mehrak Javadi-Paydar, Jacques D Nguyen, Sophia A Vandewater, Tobin J Dickerson, Michael A Taffe
The broad diversity of synthetic cathinone psychostimulant drugs that are available to users complicates research efforts to provide understanding of health risks. Second generation cathinones pentedrone and pentylone are distinguished from each other by the 3,4-methylenedioxy structural motif (which distinguishes methamphetamine from 3,4-methylenedioxymethamphetamine) and each incorporates the α-alkyl chain motif contained in the transporter-inhibitor cathinones (3,4-methylenedioxypyrovalerone (MDPV), α-pyrrolidinopentiophenone (α-PVP)) but not in the monoamine releasers (mephedrone, methylone)...
September 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28865391/discriminative-stimulus-and-locomotor-effects-of-para-substituted-and-benzofuran-analogs-of-amphetamine
#19
Sean B Dolan, Michael J Forster, Michael B Gatch
Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, often in "Ecstasy" or "Molly" formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor effects of three putatively entactogenic compounds that have become increasingly prevalent on the drug market: 5-(2-aminopropyl)-benzofuran (5-APB), 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB), and 4-fluoroamphetamine (4-FA)...
August 24, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28857950/effects-of-walking-trainings-on-walking-function-among-stroke-survivors-a-systematic-review
#20
Daudet Ilunga Tshiswaka, Crystal Bennett, Cheyanne Franklin
Physical function is often compromised as a result of stroke event. Although interventions propose different strategies that seek to improve stroke survivors' physical function, a need remains to evaluate walking training studies aimed at improving such physical function. The aim of this review was to assess the available literature that highlights the impact of walking training on enhancing walking for stroke survivors. We performed a systematic literature review of online databases - Google Scholar, PubMed, CINHAL, Cochrane Library, Scopus, and EBSCO - with the following inclusion criteria: manuscript published from 2005 to 2016, written in English, with treatment and control groups, for walking training studies aimed at improving physical function among stroke survivors...
August 29, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
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