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https://www.readbyqxmd.com/read/29353456/in-vivo-transient-and-partial-cell-reprogramming-to-pluripotency-as-a-therapeutic-tool-for-neurodegenerative-diseases
#1
REVIEW
S Tamanini, G P Comi, S Corti
In theory, human diseases in which a specific cell type degenerates, such as neurodegenerative diseases, can be therapeutically addressed by replacement of the lost cells. The classical strategy for cell replacement is exogenous cell transplantation, but now, cell replacement can also be achieved with in situ reprogramming. Indeed, many of these disorders are age-dependent, and "rejuvenating" strategies based on cell epigenetic modifications are a possible approach to counteract disease progression. In this context, transient and/or partial reprogramming of adult somatic cells towards pluripotency can be a promising tool for neuroregeneration...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29352032/the-surprising-subtleties-of-changing-fear-memory-a-challenge-for-translational-science
#2
REVIEW
Merel Kindt
Current pharmacological and psychological treatments for disorders of emotional memory only dampen the affective response while leaving the original fear memory intact. Under adverse circumstances, these original memories regain prominence, causing relapses in many patients. The (re)discovery in neuroscience that after reactivation consolidated fear memories may return to a transient labile state, requiring a process of restabilization in order to persist, offers a window of opportunity for modifying fear memories with amnestic agents...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29351678/endoscopic-transcranial-duraplasty-for-rhinoliquorrhea-a-cadaveric-study
#3
Andrea Bartoli, Jean H Fasel, Karl Schaller, Max Jägersberg
BACKGROUND: Repair of the anterior skull base for cerebrospinal fluid leak requires either endoscopic endonasal approach or open transcranial approach. OBJECTIVE: To present a less invasive surgical procedure for sealing of the entire anterior fossa floor for traumatic rhinoliquorrhea. METHODS: Cadaver study in 3 head specimens. Endoscopic placement of a furled bovine pericardial patch bilaterally along the sphenoid ridge and planum in guidewire technique...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351671/a-novel-non-invasive-method-for-evaluating-electroencephalograms-on-laying-hens
#4
Krista N Eberle, Michael P Martin, Sanjay Shah, Ramon D Malheiros, Kimberly A Livingston, Kenneth E Anderson
The use of electroencephalograms (EEG) to study the avian brain relative to behavior was conducted as early as the 1960's. EEG readings, combined with visual cues, provide the ability to elucidate and correlate behaviors to neurological and physiological changes in a chicken. The use of EEG recordings in animal models require access to the brain to implant electrodes. Having the ability to observe EEG activity on sensible birds without surgical implantation could broaden the research in this area and give further insight related to the hen's state of awareness...
January 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/29351647/minimally-invasive-lateral-retroperitoneal-approach-for-resection-of-extraforaminal-lumbar-plexus-schwannomas-operative-techniques-and-literature-review
#5
Michael M Safaee, Christopher P Ames, Vedat Deviren, Aaron J Clark
BACKGROUND: Traditional approaches for retroperitoneal lumbar plexus schwannomas involve anterior open or laparoscopic resection. For select tumors, the lateral retroperitoneal approach provides a minimally invasive alternative. OBJECTIVE: To describe a minimally invasive lateral transpsoas approach for the resection of retroperitoneal schwannomas. METHODS: A lateral retroperitoneal transpsoas approach was used to resect a 3.1 × 2.7 × 4...
January 17, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29350555/outcomes-of-latarjet-procedure-compared-with-bankart-repair-for-recurrent-traumatic-anterior-shoulder-instability
#6
Kellie C Huxel Bliven, Gail P Parr
Reference/Citation:  An VV, Sivakumar BS, Phan K, Trantalis J. A systematic review and meta-analysis of clinical and patient-reported outcomes following two procedures for recurrent traumatic anterior instability of the shoulder: Latarjet procedure vs. Bankart repair. J Shoulder Elbow Surg. 2016;25(5):853-863. CLINICAL QUESTION:   Are clinical and patient-reported outcomes different between the Latarjet and Bankart repair stabilization procedures when performed for recurrent traumatic anterior shoulder instability? DATA SOURCES:   Ovid MEDLINE, PubMed, Cochrane databases, American College of Physicians Journal Club, and Database of Abstracts of Review of Effectiveness were searched up to June 2015...
January 19, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29350372/endoscopic-diagnosis-and-treatment-of-biliary-obstruction-due-to-acute-cholangitis-and-acute-pancreatitis-secondary-to-fasciola-hepatica-infection
#7
Kemal Dolay, Mustafa Hasbahçeci, Engin Hatipoğlu, Fatma Ümit Malya, Adem Akçakaya
In the differential diagnosis of biliary obstruction with unknown etiology, biliary fascioliasis should be considered in endemic and nonendemic regions. After diagnostic evaluation, endoscopic retrograde cholangiopancreatography (ERCP) was performed for etiological evaluation and/or treatment of biliary obstruction in five patients with a mean age of 55.8 years. Endoscopic sphincterotomy and cholangiogram revealed linear filling defects in the biliary system. Fasciola hepatica parasites were extracted using balloon and basket catheters in two and three patients, respectively...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350009/-etiological-analysis-preventional-and-therapeutical-strategies-for-the-unsatisfied-cervical-posterior-decompression-surgery
#8
De-An Qin, Xiao-Guang Liu, Feng-Liang Wu, Zhong-Jun Liu, Feng-Shan Zhang, Yu Sun
OBJECTIVE: To discuss the causes of unsatisfied cervical posterior decompression surgery and describe the overhauling strategies and precaution. METHODS: The clinical data of 14 patients required revision surgery were retrospectively analyzed, and these patients with unsatisfied effects were due to cervical posterior decompression surgery from January 2012 to December 2014. Overhauling reasons were analyzed and then different revision procedures were performed. The functions of cervical cord and ambulation were evaluated respectively by modified Japanese Orthopedic Association(mJOA) score and Nurick grade according to the course order:preoperative for the first time, pre-revision and at final follow-up...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349980/-clinical-analysis-on-arthroscopic-debridement-for-the-treatment-of-early-infection-after-total-knee-replacement
#9
Hai-Bo Song, Jie Chen, Liu Hong Liux, Zhao-Hui Zhou, Jian-Feng Wang, Hao-Jie Gu
OBJECTIVE: To compare the clinical effects of arthroscopic debridement versus open debridement on controlling and treatment of infection after total knee replacement. METHODS: From October 2009 to September 2016 in three hospitals, 11 patients with 11 joints which were infected after total knee replacement were randomly divided into two groups:5 cases in arthroscopy group and 6 cases in routine group. Patients in arthroscopy group were treated with arthroscopic debridement to remove the necrotic tissues, then closed-type irrigation with sensitive antibiotics by using two sebific ducts were performed continuously for 2 or 3 weeks until the flushing fluid became clear for 3 or 5 days;other 6 patients in routine group were treated with open surgical debridement and the following procedures in keeping with those in the arthroscopy group...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349796/quantification-of-acyclovir-in-dermal-interstitial-fluid-and-human-serum-by-ultra-high-performance-liquid-chromatography-high-resolution-tandem-mass-spectrometry-for-topical-bioequivalence-evaluation
#10
Denise Schimek, Reingard Raml, Kevin A Francesconi, Manfred Bodenlenz, Frank Sinner
Time-concentration curves for the topical anti-viral drug acyclovir can provide valuable information for drug development. Open flow microperfusion (OFM) is used for continuous sampling of dermal interstitial fluid but it requires validated methods for subsequent sample analysis. Therefore, we developed a sensitive, selective and high throughput ultra-high-performance liquid chromatography-high resolution tandem mass spectrometry (UHPLC-HR MS/MS) method to determine acyclovir in human dermal interstitial fluid and serum...
January 19, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29349503/is-there-any-difference-between-open-and-arthroscopic-treatment-for-osteochondritis-dissecans-ocd-of-the-humeral-capitellum-a-systematic-review-and-meta-analysis
#11
Yi Lu, Yi Jun Li, Si Yi Guo, Hai Long Zhang
PURPOSE: We present a systematic review of the recent literatures regarding the arthroscopic and open technique in fragment fixation for osteochondritis dissecans (OCD) of the humeral capitellum and an analysis of the subjective and objective outcomes between these two procedures. METHODS: PubMed and EMBASE were reviewed for suitable articles relating to fragment fixation for OCD, both open and arthroscopic. We included all studies reporting on the clinical outcomes of these two procedures that were published in the English language...
January 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29349428/hybrid-repair-of-a-large-pseudoaneurysm-of-the-proximal-right-subclavian-artery-in-a-marfan-patient
#12
Emma van der Weijde, Jan Albert Vos, Robin H Heijmen
A pseudoaneurysm of the proximal right subclavian artery is rare and most commonly caused by penetrating or blunt trauma. We report a case of a Marfan patient with a large iatrogenic pseudoaneurysm of the right subclavian artery, induced by a puncture lesion during central venous catheter placement for an elective endovascular thoracic aortic procedure. The patient was successfully treated with a hybrid approach, which consisted of endovascular coiling and balloon occlusion of the adjacent vessels, followed by open surgical exploration and uneventful closure of the puncture hole with the use of bovine pericardium-reinforced sutures...
December 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349407/endovascular-recanalization-of-occluded-superior-mesenteric-artery-using-retrograde-access-through-the-inferior-mesenteric-artery
#13
Eduardo Keller Saadi, Gustavo Oderich, Eduardo Medronha, Rodrigo Petersen Saadi, Marina Petersen Saadi, Cristiano Jaegger
Symptomatic occlusion of the superior mesenteric artery can be treated by open repair, hybrid procedure, or endovascular revascularization. In most cases, endovascular procedures are done by the antegrade approach. We report a case of a 67-year-old woman who presented with acute-on-chronic mesenteric ischemia successfully treated by retrograde endovascular recanalization of an occluded common hepatomesenteric trunk through the inferior mesenteric artery and arc of Riolan.
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349379/common-femoral-vein-stent-placement-in-a-frozen-abdomen-causing-acute-limb-ischemia
#14
Kathleen M Lamb, Julia Glaser, Phillip Dowzicky, Paul J Foley
A 73-year-old woman was admitted for left groin bleeding through an open wound near a fungating left inguinal mass from advanced anal carcinoma. The interventional radiology service placed left iliac vein and common femoral vein stents as there was concern for communication and involvement of the left common femoral vein with the open wound, contributing to groin hemorrhage. After the procedure, the patient developed limb ischemia related to mass effect of the stent on the left common femoral vein stent artery...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349034/arthroscopic-microfracture-of-hip-chondral-lesions
#15
H Atil Atilla, T David Luo, Allston J Stubbs
Microfracture of hip chondral lesions has been performed for more than a decade with modified treatment principles and techniques from knee arthroscopy. This note and accompanying video review the pertinent techniques, pearls, and pitfalls of the microfracture procedure in the treatment of hip chondral lesions. After debridement of damaged chondral tissue, the size of the lesion is approximated to determine the number of microfracture holes to create. The working portal may be adjusted based on the site of the lesion...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349025/anterior-capsule-reconstruction-for-irreparable-subscapularis-tears
#16
Jason P Rogers, Adam Kwapisz, John M Tokish
A subscapularis complete tear presents its own challenges in management. The glenohumeral biomechanics and force couple are reliant on a competent and functioning subscapularis muscle. An irreparable subscapularis makes those same challenges even more difficult to address. Traditionally, this problem has been addressed with tendon transfers, including pectoralis major or latissimus dorsi. These techniques can alter the ideal biomechanics of the shoulder and have high rates or failure. Iliotibial autograft or tibialis anterior have also been wrought with high failure rates...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29348999/open-repair-of-quadriceps-tendon-with-suture-anchors-and-semitendinosus-tendon-allograft-augmentation
#17
Jorge Chahla, Nicholas N DePhillipo, Mark E Cinque, Nicholas I Kennedy, George F Lebus, Filippo Familiari, Gilbert Moatshe, Robert F LaPrade
Quadriceps tendinopathy in an increasingly recognized diagnosis can lead to quadriceps tendon rupture, especially in the older population. It can be caused by repeated micro trauma or also predisposed by systemic diseases such as diabetes mellitus and connective tissue disorders that can in turn lead to extensor mechanism deficits. Although a trial of conservative treatment is advocated, operative treatment should be performed in cases of persistent pain, extension deficit, or complete rupture of the tendon...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29348902/feasibility-and-outcome-of-primary-laparoscopic-cytoreductive-surgery-for-advanced-epithelial-ovarian-cancer-a-comparison-to-laparotomic-surgery-in-retrospective-cohorts
#18
Huamao Liang, Hongyan Guo, Chunyu Zhang, FuLi Zhu, Yu Wu, Kun Zhang, Hua Li, Jinsong Han
Objectives: To assess the feasibility and outcome of primary laparoscopic cytoreductive surgery on advanced epithelial ovarian cancer in comparison with conventional open surgery. Materials and Methods: Patients undergoing primary laparoscopic cytoreductive surgery (LCS) from March 2007 to December 2016 were matched to controls treated with laparotomic cytoreduction during the same period. Procedural data and outcomes were analyzed. Results: The LCS group (n = 64) and laparotomic group (n = 68) had similar age, BMI, stages, histologic type and grading...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29346792/pancreaticoduodenectomy-and-outcomes-for-groove-pancreatitis
#19
Fabiola Aguilera, Levan Tsamalaidze, Massimo Raimondo, Ruchir Puri, Horacio J Asbun, John A Stauffer
BACKGROUND/AIMS: The operative management of groove pancreatitis (GP) is still a matter of controversy and pancreaticoduodenectomy (PD) can be a high-risk procedure for patients. The aim of this study was to report our 9-year experience of surgical resection for GP and to review relevant literature. METHODS: A retrospective review of patients undergoing pancreatectomy for GP from August 1, 2008, through May 31, 2017 was performed. Patients with clinical, radiologic, and final pathologic confirmation of GP were included...
January 18, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29346608/on-demand-intraoperative-3-dimensional-printing-of-custom-cranioplastic-prostheses
#20
Alexander I Evins, John Dutton, Sayem S Imam, Amal O Dadi, Tao Xu, Du Cheng, Philip E Stieg, Antonio Bernardo
BACKGROUND: Currently, implantation of patient-specific cranial prostheses requires reoperation after a period for design and formulation by a third-party manufacturer. Recently, 3-dimensional (3D) printing via fused deposition modeling has demonstrated increased ease of use, rapid production time, and significantly reduced costs, enabling expanded potential for surgical application. Three-dimensional printing may allow neurosurgeons to remove bone, perform a rapid intraoperative scan of the opening, and 3D print custom cranioplastic prostheses during the remainder of the procedure...
January 13, 2018: Operative Neurosurgery (Hagerstown, Md.)
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