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https://www.readbyqxmd.com/read/28212569/mir-124-acts-as-a-tumor-suppressor-by-inhibiting-the-expression-of-sphingosine-kinase-1-and-its-downstream-signaling-in-head-and-neck-squamous-cell-carcinoma
#1
Yuan Zhao, Zhiqiang Ling, Yubin Hao, Xiaowu Pang, Xianlin Han, Joseph A Califano, Liang Shan, Xinbin Gu
By analyzing the expression profile of microRNAs in head and neck squamous cell carcinomas (HNSCC), we found that the expression level of miR-124 was 4.59-fold lower in tumors than in normal tissues. To understand its functions, we generated a miR-124-expressing subline (JHU-22miR124) and a mock vector-transfected subline (JHU-22vec) by transfecting the mimic of miR-124 into JHU-22 cancer cells. Restored expression of miR-124 in JHU-22miR124 cells led to reduced cell proliferation, delayed colony formation, and decreased tumor growth, indicating a tumor-suppressive effect of miR-124...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212419/evaluating-the-lexico-grammatical-differences-in-the-writing-of-native-and-non-native-speakers-of-english-in-peer-reviewed-medical-journals-in-the-field-of-pediatric-oncology-creation-of-the-genuine-index-scoring-system
#2
Alberto Alexander Gayle, Motomu Shimaoka
INTRODUCTION: The predominance of English in scientific research has created hurdles for "non-native speakers" of English. Here we present a novel application of native language identification (NLI) for the assessment of medical-scientific writing. For this purpose, we created a novel classification system whereby scoring would be based solely on text features found to be distinctive among native English speakers (NS) within a given context. We dubbed this the "Genuine Index" (GI). METHODOLOGY: This methodology was validated using a small set of journals in the field of pediatric oncology...
2017: PloS One
https://www.readbyqxmd.com/read/28212410/a-high-throughput-genetic-screen-identifies-previously-uncharacterized-borrelia-burgdorferi-genes-important-for-resistance-against-reactive-oxygen-and-nitrogen-species
#3
Meghan E Ramsey, Jenny A Hyde, Diana N Medina-Perez, Tao Lin, Lihui Gao, Maureen E Lundt, Xin Li, Steven J Norris, Jon T Skare, Linden T Hu
Borrelia burgdorferi, the causative agent of Lyme disease in humans, is exposed to reactive oxygen and nitrogen species (ROS and RNS) in both the tick vector and vertebrate reservoir hosts. B. burgdorferi contains a limited repertoire of canonical oxidative stress response genes, suggesting that novel gene functions may be important for protection of B. burgdorferi against ROS or RNS exposure. Here, we use transposon insertion sequencing (Tn-seq) to conduct an unbiased search for genes involved in resistance to nitric oxide, hydrogen peroxide, and tertiary-butyl hydroperoxide in vitro...
February 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28212379/distribution-and-abundance-of-key-vectors-of-rift-valley-fever-and-other-arboviruses-in-two-ecologically-distinct-counties-in-kenya
#4
Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander
BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis of ruminants and humans that causes outbreaks in Africa and the Arabian Peninsula with significant public health and economic consequences. Humans become infected through mosquito bites and contact with infected livestock. The virus is maintained between outbreaks through vertically infected eggs of the primary vectors of Aedes species which emerge following rains with extensive flooding. Infected female mosquitoes initiate transmission among nearby animals, which amplifies virus, thereby infecting more mosquitoes and moving the virus beyond the initial point of emergence...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28212350/a-hierarchical-framework-combining-motion-and-feature-information-for-infrared-visible-video-registration
#5
Xinglong Sun, Tingfa Xu, Jizhou Zhang, Xiangmin Li
In this paper, we propose a novel hierarchical framework that combines motion and feature information to implement infrared-visible video registration on nearly planar scenes. In contrast to previous approaches, which involve the direct use of feature matching to find the global homography, the framework adds coarse registration based on the motion vectors of targets to estimate scale and rotation prior to matching. In precise registration based on keypoint matching, the scale and rotation are used in re-location to eliminate their impact on targets and keypoints...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28212349/household-dengue-prevention-interventions-expenditures-and-barriers-to-aedes-aegypti-control-in-machala-ecuador
#6
Naveed Heydari, David A Larsen, Marco Neira, Efraín Beltrán Ayala, Prissila Fernandez, Jefferson Adrian, Rosemary Rochford, Anna M Stewart-Ibarra
The Aedes aegypti mosquito is an efficient vector for the transmission of Zika, chikungunya, and dengue viruses, causing major epidemics and a significant social and economic burden throughout the tropics and subtropics. The primary means of preventing these diseases is household-level mosquito control. However, relatively little is known about the economic burden of Ae. aegypti control in resource-limited communities. We surveyed residents from 40 households in a high-risk community at the urban periphery in the city of Machala, Ecuador, on dengue perceptions, vector control interventions, household expenditures, and factors influencing purchasing decisions...
February 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28212334/transfer-of-anti-rotavirus-antibodies-during-pregnancy-and-in-milk-following-maternal-vaccination-with-a-herpes-simplex-virus-type-1-amplicon-vector
#7
Anita F Meier, Mark Suter, Elisabeth M Schraner, Bruno M Humbel, Kurt Tobler, Mathias Ackermann, Andrea S Laimbacher
Rotaviruses (RVs) are important enteric pathogens of newborn humans and animals, causing diarrhea and in rare cases death, especially in very young individuals. Rotavirus vaccines presently used are modified live vaccines that lack complete biological safety. Previous work from our laboratory suggested that vaccines based on in situ produced, non-infectious rotavirus-like particles (RVLPs) are efficient while being entirely safe. However, using either vaccine, active mucosal immunization cannot induce protective immunity in newborns due to their immature immune system...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28212312/genome-wide-prediction-of-dna-methylation-using-dna-composition-and-sequence-complexity-in-human
#8
Chengchao Wu, Shixin Yao, Xinghao Li, Chujia Chen, Xuehai Hu
DNA methylation plays a significant role in transcriptional regulation by repressing activity. Change of the DNA methylation level is an important factor affecting the expression of target genes and downstream phenotypes. Because current experimental technologies can only assay a small proportion of CpG sites in the human genome, it is urgent to develop reliable computational models for predicting genome-wide DNA methylation. Here, we proposed a novel algorithm that accurately extracted sequence complexity features (seven features) and developed a support-vector-machine-based prediction model with integration of the reported DNA composition features (trinucleotide frequency and GC content, 65 features) by utilizing the methylation profiles of embryonic stem cells in human...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28212277/clinical-and-molecular-evidence-of-abcc11-protein-expression-in-axillary-apocrine-glands-of-patients-with-axillary-osmidrosis
#9
Yu Toyoda, Tappei Takada, Tsuneaki Gomi, Hiroshi Nakagawa, Toshihisa Ishikawa, Hiroshi Suzuki
Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 (ABCC11) gene. However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. To determine the effect of the non-synonymous SNP ABCC11 538G>A (G180R) on the ABCC11 in vivo, we generated transiently ABCC11-expressing transgenic mice with adenovirus vector, and examined the protein levels of each ABCC11 in the mice with immunoblotting using an anti-ABCC11 antibody we have generated in the present study...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28212101/fast-solving-quasi-optimal-ls-s-%C3%A2-vm-based-on-an-extended-candidate-set
#10
Yuefeng Ma, Xun Liang, James T Kwok, Jianping Li, Xiaoping Zhou, Haiyan Zhang
The semisupervised least squares support vector machine (LS-S³VM) is an important enhancement of least squares support vector machines in semisupervised learning. Given that most data collected from the real world are without labels, semisupervised approaches are more applicable than standard supervised approaches. Although a few training methods for LS-S³VM exist, the problem of deriving the optimal decision hyperplane efficiently and effectually has not been solved. In this paper, a fully weighted model of LS-S³VM is proposed, and a simple integer programming (IP) model is introduced through an equivalent transformation to solve the model...
February 14, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28212096/system-level-design-of-a-64-channel-low-power-neural-spike-recording-sensor
#11
Manuel Delgado-Restituto, Alberto Rodriguez-Perez, Angela Darie, Cristina Soto-Sanchez, Eduardo Fernandez-Jover, Angel Rodriguez-Vazquez
This paper reports an integrated 64-channel neural spike recording sensor, together with all the circuitry to process and configure the channels, process the neural data, transmit via a wireless link the information and receive the required instructions. Neural signals are acquired, filtered, digitized and compressed in the channels. Additionally, each channel implements an auto-calibration algorithm which individually configures the transfer characteristics of the recording site. The system has two transmission modes; in one case the information captured by the channels is sent as uncompressed raw data; in the other, feature vectors extracted from the detected neural spikes are released...
February 13, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28212085/contextual-noise-reduction-for-domain-adaptive-near-duplicate-retrieval-on-merchandize-images
#12
Zhen-Qun Yang, Xiao-Yong Wei, Zhang Yi, Gerald Friedland
In this paper, we have proposed a novel method which utilizes the contextual relationship among visual words for reducing the Quantization errors in near-duplicate image retrieval (NDR). Instead of following the track of conventional NDR techniques which usually search new solutions by borrowing ideas from the text domain, we propose to model the problem back to image domain, which results in a more natural way of solution search. The idea of the proposed method is to construct a context graph that encapsulates the contextual relationship within an image and treat the graph as a pseudo-image, so that classical image filters can be adopted to reduce the mismapped visual words which are contextually inconsistent with others...
February 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28211908/the-n-terminal-domain-of-schmallenberg-virus-envelope-protein-gc-is-highly-immunogenic-and-can-provide-protection-from-infection
#13
Kerstin Wernike, Andrea Aebischer, Gleyder Roman-Sosa, Martin Beer
Schmallenberg virus (SBV) is transmitted by insect vectors, and therefore vaccination is one of the most important tools of disease control. In our study, novel subunit vaccines on the basis of an amino-terminal domain of SBV Gc of 234 amino acids ("Gc Amino") first were tested and selected using a lethal small animal challenge model and then the best performing formulations also were tested in cattle. We could show that neither E. coli expressed nor the reduced form of "Gc Amino" protected from SBV infection...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211852/plasmodium-falciparum-crk4-directs-continuous-rounds-of-dna-replication-during-schizogony
#14
Markus Ganter, Jonathan M Goldberg, Jeffrey D Dvorin, Joao A Paulo, Jonas G King, Abhai K Tripathi, Aditya S Paul, Jing Yang, Isabelle Coppens, Rays H Y Jiang, Brendan Elsworth, David A Baker, Rhoel R Dinglasan, Steven P Gygi, Manoj T Duraisingh
Plasmodium parasites, the causative agents of malaria, have evolved a unique cell division cycle in the clinically relevant asexual blood stage of infection(1). DNA replication commences approximately halfway through the intracellular development following invasion and parasite growth. The schizont stage is associated with multiple rounds of DNA replication and nuclear division without cytokinesis, resulting in a multinucleated cell. Nuclei divide asynchronously through schizogony, with only the final round of DNA replication and segregation being synchronous and coordinated with daughter cell assembly(2,3)...
February 17, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28211730/kinetic-turbulence-in-relativistic-plasma-from-thermal-bath-to-nonthermal-continuum
#15
Vladimir Zhdankin, Gregory R Werner, Dmitri A Uzdensky, Mitchell C Begelman
We present results from particle-in-cell simulations of driven turbulence in magnetized, collisionless, and relativistic pair plasmas. We find that the fluctuations are consistent with the classical k_{⊥}^{-5/3} magnetic energy spectrum at fluid scales and a steeper k_{⊥}^{-4} spectrum at sub-Larmor scales, where k_{⊥} is the wave vector perpendicular to the mean field. We demonstrate the development of a nonthermal, power-law particle energy distribution f(E)∼E^{-α}, with an index α that decreases with increasing magnetization and increases with an increasing system size (relative to the characteristic Larmor radius)...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211724/experimental-evidence-for-static-charge-density-waves-in-iron-oxypnictides
#16
A Martinelli, P Manfrinetti, A Provino, A Genovese, F Caglieris, G Lamura, C Ritter, M Putti
In this Letter we report high-resolution synchrotron x-ray powder diffraction and transmission electron microscope analysis of Mn-substituted LaFeAsO samples, demonstrating that a static incommensurate modulated structure develops across the low-temperature orthorhombic phase, whose modulation wave vector depends on the Mn content. The incommensurate structural distortion is likely originating from a charge-density-wave instability, a periodic modulation of the density of conduction electrons associated with a modulation of the atomic positions...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211367/high-quality-four-dimensional-cone-beam-ct-reconstruction-using-motion-compensated-total-variation-regularization
#17
Hua Zhang, Jianhua Ma, Zhaoying Bian, Dong Zeng, Qianjin Feng, Wufan Chen
Four dimensional cone-beam computed tomography (4D-CBCT) has great potential clinical value because its ability to describe tumor and organ motion. But the challenge in 4D-CBCT reconstruction is the limited number of projections at each phase, which resulting in the reconstruction full of noise and streak artifacts with the conventional analytical algorithms. To address this problem, in this paper, we propose a motion compensated total variation regularization approach which tries to maximum explore the temporal coherence of the spatial structures among 4D-CBCT phases...
February 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28211294/hemopred-a-web-server-for-predicting-the-hemolytic-activity-of-peptides
#18
Thet Su Win, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenamat, Watshara Shoombuatong
AIM: Toxicity arising from hemolytic activity of peptides hinders its further progress as drug candidates. MATERIALS & METHODS: This study describes a sequence-based predictor based on a random forest classifier using amino acid composition, dipeptide composition and physicochemical descriptors (named HemoPred). RESULTS: This approach could outperform previously reported method and typical classification methods (e.g., support vector machine and decision tree) verified by fivefold cross-validation and external validation with accuracy and Matthews correlation coefficient in excess of 95% and 0...
February 17, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28211087/semiparametric-pseudoscore-for-regression-with-multidimensional-but-incompletely-observed-regressor
#19
Zonghui Hu, Jing Qin, Dean Follmann
We study the regression fβ (Y|X,Z), where Y is the response, Z∈Rd is a vector of fully observed regressors and X is the regressor with incomplete observation. To handle missing data, maximum likelihood estimation via expectation-maximisation (EM) is the most efficient but is sensitive to the specification of the distribution of X. Under a missing at random assumption, we propose an EM-type estimation via a semiparametric pseudoscore. Like in EM, we derive the conditional expectation of the score function given Y and Z, or the mean score, over the incompletely observed units under a postulated distribution of X...
February 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28210460/cloning-and-expression-of-clostridium-perfringens-type-d-vaccine-strain-epsilon-toxin-gene-in-e-coli-as-a-recombinant-vaccine-candidate
#20
Parastoo Aziminia, Reza Pilehchian-Langroudi, Kasra Esmaeilnia
BACKGROUND AND OBJECTIVES: Clostridium perfringens, a Gram-positive obligate anaerobic bacterium, is able to form resistant spores which are widely distributed in the environment. C. perfringens is subdivided into five types A to E based on its four major alpha, beta, epsilon and iota toxins. The aim of the present study was cloning and expression of C. perfringens type D vaccine strain epsilon toxin gene. MATERIALS AND METHODS: Genomic DNA was extracted and the epsilon toxin gene was amplified using Pfu DNA polymerase...
August 2016: Iranian Journal of Microbiology
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