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Benjamin D Bray, Lizz Paley, Alex Hoffman, Martin James, Patrick Gompertz, Charles D A Wolfe, Harry Hemingway, Anthony G Rudd
BACKGROUND: We aimed to estimate socioeconomic disparities in the incidence of hospitalisation for first-ever stroke, quality of care, and post-stroke survival for the adult population of England. METHODS: In this cohort study, we obtained data collected by a nationwide register on patients aged 18 years or older hospitalised for first-ever acute ischaemic stroke or primary intracerebral haemorrhage in England from July 1, 2013, to March 31, 2016. We classified socioeconomic status at the level of Lower Super Output Areas using the Index of Multiple Deprivation, a neighbourhood measure of deprivation...
March 14, 2018: Lancet. Public Health
Christopher A Iobst, S Robert Rozbruch, Scott Nelson, Austin Fragomen
INTRODUCTION: Patients with limb-length discrepancies often have concomitant deformity. We describe the outcomes of acute, fixator-assisted deformity correction with gradual lengthening using the retrograde femoral Precice nail (NuVasive). METHODS: We analyzed a retrospective series of 27 patients in whom an external fixator was combined with a Precice nail to correct angular or rotational deformity and limb-length discrepancy. The fixator was applied temporarily to restore normal alignment...
February 27, 2018: Journal of the American Academy of Orthopaedic Surgeons
Chirag Gheewala, Jennifer S Hirschi, Wai-Hang Lee, Daniel W Paley, Mathew J Vetticatt, Tristan H Lambert
An enantioselective catalytic inverse electron-demand Diels-Alder reaction of salicylaldehyde acetal-derived oxocarbenium ions and vinyl ethers to generate 2,4-dioxychromanes is described. Chiral PCCP acids are found to be effective for a variety of substrates. Computational and X-ray crystallographic analyses support the unique hypothesis that a point chirality-induced, helically chiral anion dictates the absolute sense of stereochemistry in this reaction.
February 27, 2018: Journal of the American Chemical Society
Grace L Paley, Nathan H Kung, Robert C Bucelli, Todd P Margolis, Gregory P Van Stavern
No abstract text is available yet for this article.
February 22, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Alejandro P Gutierrez, Tim P Bean, Chantelle Hooper, Craig A Stenton, Matthew B Sanders, Richard K Paley, Pasi Rastas, Michaela Bryrom, Oswald Matika, Ross D Houston
Ostreid herpesvirus (OsHV) can cause mass mortality events in Pacific oyster aquaculture. While various factors impact on the severity of outbreaks, it is clear that genetic resistance of the host is an important determinant of mortality levels. This raises the possibility of selective breeding strategies to improve the genetic resistance of farmed oyster stocks, thereby contributing to disease control. Traditional selective breeding can be augmented by use of genetic markers, either via marker-assisted or genomic selection...
February 22, 2018: G3: Genes—Genomes—Genetics
Dympna Gallagher, Barak Rosenn, Tatiana Toro-Ramos, Charles Paley, Sonia Gidwani, Michelle Horowitz, Janet Crane, Susan Lin, John C Thornton, Xavier Pi-Sunyer
OBJECTIVE: The objective of this study was to determine the effectiveness of controlling maternal gestational weight gain (GWG) in the second and third trimesters on neonate body composition. METHODS: Two hundred ten healthy women with overweight (25 > BMI < 30) or obesity (BMI ≥ 30) were randomly assigned to a lifestyle intervention (LI) program focused on controlling GWG through nutrition and activity behaviors or to usual obstetrical care (UC). Infant fat and fat-free mass (FFM) at birth were measured by using air displacement plethysmography (PEA POD) and by using quantitative magnetic resonance (QMR)...
March 2018: Obesity
Peter D Karp, Richard Billington, Ron Caspi, Carol A Fulcher, Mario Latendresse, Anamika Kothari, Ingrid M Keseler, Markus Krummenacker, Peter E Midford, Quang Ong, Wai Kit Ong, Suzanne M Paley, Pallavi Subhraveti is a microbial genome Web portal that combines thousands of genomes with additional information inferred by computer programs, imported from other databases and curated from the biomedical literature by biologist curators. BioCyc also provides an extensive range of query tools, visualization services and analysis software. Recent advances in BioCyc include an expansion in the content of BioCyc in terms of both the number of genomes and the types of information available for each genome; an expansion in the amount of curated content within BioCyc; and new developments in the BioCyc software tools including redesigned gene/protein pages and metabolite pages; new search tools; a new sequence-alignment tool; a new tool for visualizing groups of related metabolic pathways; and a facility called SmartTables, which enables biologists to perform analyses that previously would have required a programmer's assistance...
August 17, 2017: Briefings in Bioinformatics
Salma Sana, Chris Williams, Emilie A Hardouin, Adrian Blake, Phil Davison, Josie Pegg, Richard Paley, Tiantian Zhang, Demetra Andreou
Species translocation leads to disease emergence in native species of considerable economic importance. Generalist parasites are more likely to be transported, become established and infect new hosts, thus their risk needs to be evaluated. Freshwater systems are particularly at risk from parasite introductions due to the frequency of fish movements, lack of international legislative controls for non-listed pathogens and inherent difficulties with monitoring disease introductions in wild fish populations. Here we used one of the world's most invasive freshwater fish, the topmouth gudegon, Pseudorasbora parva, to demonstrate the risk posed by an emergent generalist parasite, Sphaerothecum destruens...
February 10, 2018: International Journal for Parasitology
B L Murphy, D S Ubl, J Zhang, E B Habermann, D Farley, K Paley
PURPOSE: Recurrence rates after femoral hernia repair (FHR) have not been reliably established in the USA. We sought to determine this trend over time. METHODS: The proportion of primary and recurrent FHRs was determined for patients age ≥ 18 from: ACS-NSQIP (1/2005-12/2014), Premier (1/2010-09/2015), and institutional (1/2005-12/2014) data. Trends were analyzed using a one-tailed Cochran-Armitage test. RESULTS: In the NSQIP database, 6649 patients underwent a FHR...
February 6, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Elena L Paley, Tatiana Merkulova-Rainon, Aleksandr Faynboym, Valery I Shestopalov, Igor Aksenoff
Earlier we reported induction of neurotoxicity and neurodegeneration by tryptophan metabolites that link the metabolic alterations to Alzheimer's disease (AD). Tryptophan is a product of Shikimate pathway (SP). Human cells lack SP, which is found in human gut bacteria exclusively using SP to produce aromatic amino acids (AAA). This study is a first attempt toward gene-targeted analysis of human gut microbiota in AD fecal samples. The oligonucleotide primers newly-designed for this work target SP-AAA in environmental bacteria associated with human activity...
2018: Journal of Alzheimer's Disease: JAD
Brian Anderson Free, Derek Paley
Obstacles and swimming fish in flow create a wake with an alternating left/right vortex pattern known as a Karman vortex street and reverse Karman vortex street, respectively. An energy-efficient fish behavior resembling slaloming through the vortex street is called Karman gaiting. This paper describes the use of a bioinspired array of pressure sensors on a Joukowski foil to estimate and control flow-relative position in a Karman vortex street using potential flow theory, recursive Bayesian filtering, and trajectory-tracking feedback control...
January 22, 2018: Bioinspiration & Biomimetics
Jian Xiao, Zhao-Guang Mao, Hui-Hua Zhu, Liang Guo
OBJECTIVE: To discuss the curative effect of the early application of the antibiotic-laden bone cement (ALBC) combined with the external fixation support in treating the open fractures of lower limbs complicated with bone defect. METHODS: From December 2013 to January 2015, 36 cases of lower limb open comminuted fractures complicated with bone defects were treated by the vancomycin ALBC combined with the external fixation support, including 26 males and 10 females with an average age of 38...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Yongwei Wu, Qudong Yin, Yongjun Rui, Zhenzhong Sun, Sanjun Gu
OBJECTIVE: To compare the outcomes of bone transport and bone shortening-lengthening by Ilizarov technique for treatment of tibial bone and soft-tissue defects. METHODS: Fifty patients with tibial bone and soft-tissue defects were treated by Ilizarov technique from January 2007 to June 2016. Two subgroups were treated by either bone transport (group A) containing 28 cases or bone shortening-lengthening (group B) including 22 cases. RESULTS: Bony union was achieved at the distracted sites with a mean of 236 days in group A, while 240 days in group B, showing no significant difference (t = -0...
December 28, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Kaleab Z Abebe, Kelley A Jones, Dana Rofey, Heather L McCauley, Duncan B Clark, Rebecca Dick, Theresa Gmelin, Janine Talis, Jocelyn Anderson, Carla Chugani, Gabriela Algarroba, Ashley Antonio, Courtney Bee, Clare Edwards, Nadia Lethihet, Justin Macak, Joshua Paley, Irving Torres, Courtney Van Dusen, Elizabeth Miller
INTRODUCTION: Sexual violence (SV) on college campuses is common, especially alcohol-related SV. This is a 2-arm cluster randomized controlled trial to test a brief intervention to reduce risk for alcohol-related sexual violence (SV) among students receiving care from college health centers (CHCs). Intervention CHC staff are trained to deliver universal SV education to all students seeking care, to facilitate patient and provider comfort in discussing SV and related abusive experiences (including the role of alcohol)...
December 26, 2017: Contemporary Clinical Trials
Marco Basso, Valentina Camurri, Piero Frediani, Silvio Boero
We report a nine-year-old boy with a type IIIa tibial hemimelia, according to the new Paley classification. We describe the x-ray findings, the surgical treatment technique, and the prognostic course of the patient. Descriptions of such cases are very infrequent in the literature and type of treatment is still object of debate.
December 13, 2017: Acta Orthopaedica et Traumatologica Turcica
Suzanne Paley, Peter D Karp , ,
January 1, 2017: Database: the Journal of Biological Databases and Curation
Octavi E Semonin, Giselle A Elbaz, Daniel B Straus, Trevor D Hull, Daniel W Paley, Arend M Van der Zande, James C Hone, Ioannis Kymissis, Cherie R Kagan, Xavier Roy, Jonathan S Owen
No abstract text is available yet for this article.
December 21, 2017: Journal of Physical Chemistry Letters
Evan S O'Brien, M Tuan Trinh, Rose L Kann, Jia Chen, Giselle A Elbaz, Amrita Masurkar, Timothy L Atallah, Maria V Paley, Nilam Patel, Daniel W Paley, Ioannis Kymissis, Andrew C Crowther, Andrew J Millis, David R Reichman, X-Y Zhu, Xavier Roy
The controlled introduction of impurities into the crystal lattice of solid-state compounds is a cornerstone of materials science. Intercalation, the insertion of guest atoms, ions or molecules between the atomic layers of a host structure, can produce novel electronic, magnetic and optical properties in many materials. Here we describe an intercalation compound in which the host [Co6 Te8 (Pn Pr3 )6 ][C60 ]3 , formed from the binary assembly of atomically precise molecular clusters, is a superatomic analogue of traditional layered atomic compounds...
December 2017: Nature Chemistry
Jessica L Wilczek, Guido A LaPorta
Limb deformity correction has been widely discussed in orthopedic literature with an increasing interest in technologically based surgical strategies. However, principles described by Ilizarov and Paley still form the basis of these newly developing surgical systems. The recent advances and increased use of computers and mobile devices in the medical arena, along with the application of dynamic hexapod external fixation, have allowed for easier and more convenient strategies, leading to a greater outreach and more confidence in the newer surgeon when faced with addressing a patient with a limb deformity...
January 2018: Clinics in Podiatric Medicine and Surgery
Irene Cano, Ronny van Aerle, Stuart Ross, David W Verner-Jeffreys, Richard K Paley, Georgina Rimmer, David Ryder, Patrick Hooper, David Stone, Stephen W Feist
One of the fastest growing fisheries in the UK is the king scallop Pecten maximus L., also currently rated as the second most valuable. Mass mortality events in scallops have been reported world-wide, often with the causative agent(s) remaining uncharacterized. In May 2013 and 2014, two mass mortality events affecting king scallops were recorded in the Lyme Bay Marine Protected Area (MPA), in South West England. Histopathological examination showed gill epithelial tissues infected with intracellular microcolonies of bacteria (IMC), resembling rickettsia-like organisms (RLOs), often with bacteria released in vascular spaces...
November 17, 2017: Applied and Environmental Microbiology
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