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https://www.readbyqxmd.com/read/27909861/surgical-reconstruction-for-fibular-hemimelia
#1
REVIEW
Dror Paley
Fibular hemimelia presents with foot deformity and leg length discrepancy. Previous classifications have focused on the degree of fibular deficiency rather than the type of foot deformity. Published methods of surgical reconstruction have often failed due to residual or recurrent foot deformity. The purpose of this report is to introduce new classification and reconstruction methods. The Paley SHORDT procedure is used to stabilize the ankle when there is a hypoplastic distal fibula with a dynamic valgus deformity...
December 1, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27909860/tibial-hemimelia-new-classification-and-reconstructive-options
#2
REVIEW
Dror Paley
Tibial hemimelia is a rare congenital lower limb deficiency presenting with a wide spectrum of associated congenital anomalies, deficiencies and duplications. Reconstructive options have been limited, and the gold standard for treatment has remained amputation with prosthetic fitting. There is now a better understanding of the genetics, etiology and pathoanatomy of tibial hemimelia. Armed with this knowledge, I present here a new classification to guide treatment and prognosis and then discuss new treatment strategies and techniques for limb reconstruction based on this new classification scheme...
December 1, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27907996/probabilistic-information-transmission-in-a-network-of-coupled-oscillators-reveals-speed-accuracy-trade-off-in-responding-to-threats
#3
Amanda Chicoli, Derek A Paley
Individuals in a group may obtain information from other group members about the environment, including the location of a food source or the presence of a predator. Here, we model how information spreads in a group using a susceptible-infected-removed epidemic model. We apply this model to a simulated shoal of fish using the motion dynamics of a coupled oscillator model, in order to test the biological hypothesis that polarized or aligned shoaling leads to faster and more accurate escape responses. The contributions of this study are the (i) application of a probabilistic model of epidemics to the study of collective animal behavior; (ii) testing the biological hypothesis that group cohesion improves predator escape; (iii) quantification of the effect of social cues on startle propagation; and (iv) investigation of the variation in response based on network connectivity...
November 2016: Chaos
https://www.readbyqxmd.com/read/27899573/the-ecocyc-database-reflecting-new-knowledge-about-escherichia-coli-k-12
#4
Ingrid M Keseler, Amanda Mackie, Alberto Santos-Zavaleta, Richard Billington, César Bonavides-Martínez, Ron Caspi, Carol Fulcher, Socorro Gama-Castro, Anamika Kothari, Markus Krummenacker, Mario Latendresse, Luis Muñiz-Rascado, Quang Ong, Suzanne Paley, Martin Peralta-Gil, Pallavi Subhraveti, David A Velázquez-Ramírez, Daniel Weaver, Julio Collado-Vides, Ian Paulsen, Peter D Karp
EcoCyc (EcoCyc.org) is a freely accessible, comprehensive database that collects and summarizes experimental data for Escherichia coli K-12, the best-studied bacterial model organism. New experimental discoveries about gene products, their function and regulation, new metabolic pathways, enzymes and cofactors are regularly added to EcoCyc. New SmartTable tools allow users to browse collections of related EcoCyc content. SmartTables can also serve as repositories for user- or curator-generated lists. EcoCyc now supports running and modifying E...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27892743/muscle-strength-and-knee-range-of-motion-after-femoral-lengthening
#5
Anil Bhave, Lior Shabtai, Erik Woelber, Arman Apelyan, Dror Paley, John E Herzenberg
Background and purpose - Femoral lengthening may result in decrease in knee range of motion (ROM) and quadriceps and hamstring muscle weakness. We evaluated preoperative and postoperative knee ROM, hamstring muscle strength, and quadriceps muscle strength in a diverse group of patients undergoing femoral lengthening. We hypothesized that lengthening would not result in a significant change in knee ROM or muscle strength. Patients and methods - This prospective study of 48 patients (mean age 27 (9-60) years) compared ROM and muscle strength before and after femoral lengthening...
November 28, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27837313/cosmetic-lengthening-what-are-the-limits
#6
F Guerreschi, H Tsibidakis
OBJECTIVES: In the last decades, limb lengthening has not been limited to the treatment of patients with dwarfism and deformities resulting from congenital anomalies, trauma, tumor and infections, but, has also been used for aesthetic reasons. Cosmetic lengthening by the Ilizarov method with circular external fixation has been applied to individuals with constitutional short stature who wish to be taller. MATERIALS AND METHODS: From January 1985 to December 2010, the medical records of 63 patients with constitutional short stature (36 M, 27F; 126 legs) who underwent cosmetic bilateral leg lengthening using a hybrid advanced fixator according to the Ilizarov method, were reviewed, retrospectively...
November 11, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27790071/macrosteres-the-deltic-guanidinium-ion
#7
Kenji Mishiro, Fanghao Hu, Daniel W Paley, Wei Min, Tristan H Lambert
The "deltic guanidinium" ion is described here as a "macrostere" of the guanidinium ion. The use of the 2,4-dimethoxybenzyl protecting group allows for the synthesis of the fully unsubstituted parent compound and a variety of derivatives bearing multiple N-H functions for the first time. Deltic urea, deltic thiourea, and deltic benzamidine are also synthesized. A comparison of the physical properties of guanidinium and deltic guanidinium ions is provided. The use of a deltic guanidinium dendrimer for cell transport is demonstrated...
March 2016: European Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27777928/cervicovaginal-fluid-acetate-a-metabolite-marker-of-preterm-birth-in-symptomatic-pregnant-women
#8
Emmanuel Amabebe, Steven Reynolds, Victoria Stern, Graham Stafford, Martyn Paley, Dilly O C Anumba
Changes in vaginal microbiota that is associated with preterm birth (PTB) leave specific metabolite fingerprints that can be detected in the cervicovaginal fluid (CVF) using metabolomics techniques. In this study, we characterize and validate the CVF metabolite profile of pregnant women presenting with symptoms of threatened preterm labor (PTL) by both (1)H-nuclear magnetic resonance spectroscopy (NMR) and enzyme-based spectrophotometry. We also determine their predictive capacity for PTB, singly, and in combination, with current clinical screening tools - cervicovaginal fetal fibronectin (FFN) and ultrasound cervical length (CL)...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27771070/corrigendum-to-in-vivo-virulence-of-viral-haemorrhagic-septicaemia-virus-vhsv-in-rainbow-trout-oncorhynchus-mykiss-correlates-inversely-with-in-vitro-mx-gene-expression-vet-microbiol-187-2016-31-40
#9
Irene Cano, Bertrand Collet, Clarissa Pereira, Richard Paley, Ronny van Aerle, David Stone, Nick G H Taylor
No abstract text is available yet for this article.
November 15, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27768356/limits-on-active-to-sterile-neutrino-oscillations-from-disappearance-searches-in-the-minos-daya-bay-and-bugey-3-experiments
#10
P Adamson, F P An, I Anghel, A Aurisano, A B Balantekin, H R Band, G Barr, M Bishai, A Blake, S Blyth, G J Bock, D Bogert, D Cao, G F Cao, J Cao, S V Cao, T J Carroll, C M Castromonte, W R Cen, Y L Chan, J F Chang, L C Chang, Y Chang, H S Chen, Q Y Chen, R Chen, S M Chen, Y Chen, Y X Chen, J Cheng, J-H Cheng, Y P Cheng, Z K Cheng, J J Cherwinka, S Childress, M C Chu, A Chukanov, J A B Coelho, L Corwin, D Cronin-Hennessy, J P Cummings, J de Arcos, S De Rijck, Z Y Deng, A V Devan, N E Devenish, X F Ding, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R Gill, R A Gomes, M Gonchar, G H Gong, H Gong, M C Goodman, P Gouffon, N Graf, R Gran, M Grassi, K Grzelak, W Q Gu, M Y Guan, L Guo, R P Guo, X H Guo, Z Guo, A Habig, R W Hackenburg, S R Hahn, R Han, S Hans, J Hartnell, R Hatcher, M He, K M Heeger, Y K Heng, A Higuera, A Holin, Y K Hor, Y B Hsiung, B Z Hu, T Hu, W Hu, E C Huang, H X Huang, J Huang, X T Huang, P Huber, W Huo, G Hussain, J Hylen, G M Irwin, Z Isvan, D E Jaffe, P Jaffke, C James, K L Jen, D Jensen, S Jetter, X L Ji, X P Ji, J B Jiao, R A Johnson, J K de Jong, J Joshi, T Kafka, L Kang, S M S Kasahara, S H Kettell, S Kohn, G Koizumi, M Kordosky, M Kramer, A Kreymer, K K Kwan, M W Kwok, T Kwok, K Lang, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, P J Litchfield, L Littenberg, B R Littlejohn, D W Liu, J C Liu, J L Liu, C W Loh, C Lu, H Q Lu, J S Lu, P Lucas, K B Luk, Z Lv, Q M Ma, X B Ma, X Y Ma, Y Q Ma, Y Malyshkin, W A Mann, M L Marshak, D A Martinez Caicedo, N Mayer, K T McDonald, C McGivern, R D McKeown, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, I Mitchell, M Mooney, C D Moore, L Mualem, J Musser, Y Nakajima, D Naples, J Napolitano, D Naumov, E Naumova, J K Nelson, H B Newman, H Y Ngai, R J Nichol, Z Ning, J A Nowak, J O'Connor, J P Ochoa-Ricoux, A Olshevskiy, M Orchanian, R B Pahlka, J Paley, H-R Pan, J Park, R B Patterson, S Patton, G Pawloski, V Pec, J C Peng, A Perch, M M Pfützner, D D Phan, S Phan-Budd, L Pinsky, R K Plunkett, N Poonthottathil, C S J Pun, F Z Qi, M Qi, X Qian, X Qiu, A Radovic, N Raper, B Rebel, J Ren, C Rosenfeld, R Rosero, B Roskovec, X C Ruan, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, S Moed Sher, A Sousa, H Steiner, G X Sun, J L Sun, N Tagg, R L Talaga, W Tang, D Taychenachev, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, K Treskov, K V Tsang, C E Tull, G Tzanakos, J Urheim, P Vahle, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z M Wang, R C Webb, A Weber, H Y Wei, L J Wen, K Whisnant, C White, L Whitehead, L H Whitehead, T Wise, S G Wojcicki, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, J Y Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, H H Zhang, J W Zhang, Q M Zhang, X T Zhang, Y M Zhang, Y X Zhang, Z J Zhang, Z P Zhang, Z Y Zhang, J Zhao, Q W Zhao, Y B Zhao, W L Zhong, L Zhou, N Zhou, H L Zhuang, J H Zou
Searches for a light sterile neutrino have been performed independently by the MINOS and the Daya Bay experiments using the muon (anti)neutrino and electron antineutrino disappearance channels, respectively. In this Letter, results from both experiments are combined with those from the Bugey-3 reactor neutrino experiment to constrain oscillations into light sterile neutrinos. The three experiments are sensitive to complementary regions of parameter space, enabling the combined analysis to probe regions allowed by the Liquid Scintillator Neutrino Detector (LSND) and MiniBooNE experiments in a minimally extended four-neutrino flavor framework...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27768323/search-for-sterile-neutrinos-mixing-with-muon-neutrinos-in-minos
#11
P Adamson, I Anghel, A Aurisano, G Barr, M Bishai, A Blake, G J Bock, D Bogert, S V Cao, T J Carroll, C M Castromonte, R Chen, S Childress, J A B Coelho, L Corwin, D Cronin-Hennessy, J K de Jong, S De Rijck, A V Devan, N E Devenish, M V Diwan, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R A Gomes, M C Goodman, P Gouffon, N Graf, R Gran, K Grzelak, A Habig, S R Hahn, J Hartnell, R Hatcher, A Holin, J Huang, J Hylen, G M Irwin, Z Isvan, C James, D Jensen, T Kafka, S M S Kasahara, G Koizumi, M Kordosky, A Kreymer, K Lang, J Ling, P J Litchfield, P Lucas, W A Mann, M L Marshak, N Mayer, C McGivern, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, S Moed Sher, C D Moore, L Mualem, J Musser, D Naples, J K Nelson, H B Newman, R J Nichol, J A Nowak, J O'Connor, M Orchanian, R B Pahlka, J Paley, R B Patterson, G Pawloski, A Perch, M M Pfützner, D D Phan, S Phan-Budd, R K Plunkett, N Poonthottathil, X Qiu, A Radovic, B Rebel, C Rosenfeld, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, A Sousa, N Tagg, R L Talaga, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, G Tzanakos, J Urheim, P Vahle, B Viren, A Weber, R C Webb, C White, L Whitehead, L H Whitehead, S G Wojcicki, R Zwaska
We report results of a search for oscillations involving a light sterile neutrino over distances of 1.04 and 735 km in a ν_{μ}-dominated beam with a peak energy of 3 GeV. The data, from an exposure of 10.56×10^{20} protons on target, are analyzed using a phenomenological model with one sterile neutrino. We constrain the mixing parameters θ_{24} and Δm_{41}^{2} and set limits on parameters of the four-dimensional Pontecorvo-Maki-Nakagawa-Sakata matrix, |U_{μ4}|^{2} and |U_{τ4}|^{2}, under the assumption that mixing between ν_{e} and ν_{s} is negligible (|U_{e4}|^{2}=0)...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27717214/electron-delocalization-in-perylene-diimide-helicenes
#12
Nathaniel J Schuster, Daniel W Paley, Steffen Jockusch, Fay Ng, Michael L Steigerwald, Colin Nuckolls
We report two new helicenes derived from the double fusion of an acene with two perylene diimide (PDI) subunits. These PDI-helicene homologs exhibit very different structural and electronic properties, despite differing by only a single ring in the link between the PDI units. The shorter inter-PDI link brings the two PDI subunits closer together, and this results in the collision of their respective π-electron clouds. This collision facilitates intramolecular through-space electronic delocalization when the PDI-helicene is reduced...
October 17, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27709436/rapid-and-sensitive-detection-of-lymphocystis-disease-virus-genotype-vii-by-loop-mediated-isothermal-amplification
#13
Estefanía J Valverde, Irene Cano, Dolores Castro, Richard K Paley, Juan J Borrego
Lymphocystis disease virus (LCDV) infections have been described in gilthead seabream (Sparus aurata L.) and Senegalese sole (Solea senegalensis, Kaup), two of the most important marine fish species in the Mediterranean aquaculture. In this study, a rapid, specific, and sensitive detection method for LCDV genotype VII based on loop-mediated isothermal amplification (LAMP) was developed. The LAMP assay, performed using an apparatus with real-time amplification monitoring, was able to specifically detect LCDV genotype VII from clinically positive samples in less than 12 min...
October 5, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27692528/pediatric-idiopathic-intracranial-hypertension-age-gender-and-anthropometric-features-at-diagnosis-in-a-large-retrospective-multisite-cohort
#14
Claire A Sheldon, Grace L Paley, Rui Xiao, Anat Kesler, Ori Eyal, Melissa W Ko, Chantal J Boisvert, Robert A Avery, Vincenzo Salpietro, Paul H Phillips, Gena Heidary, Shana E McCormack, Grant T Liu
PURPOSE: To examine anthropometric and maturational characteristics at diagnosis in pediatric idiopathic intracranial hypertension (IIH). DESIGN: Retrospective, international, multisite study. PARTICIPANTS: Pediatric patients (2-18 years of age at diagnosis) with IIH. MAIN OUTCOME MEASURES: Body mass index (BMI), height, and weight Z-scores; sexual maturation. METHODS: Cases of IIH were identified retrospectively based on diagnostic code, pediatric neuro-ophthalmologist databases, or both and updated diagnostic criteria (2013) were applied to confirm definite IIH...
September 27, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27678508/hip-stability-during-lengthening-in-children-with-congenital-femoral-deficiency
#15
Mark Eidelman, Julio J Jauregui, Shawn C Standard, Dror Paley, John E Herzenberg
BACKGROUND: Congenital femoral deficiency (CFD) is one of the most challenging and complex conditions for limb lengthening. We focused on the problem of hip instability during femoral lengthening because subluxation and dislocation are potentially catastrophic for hip function. METHODS: We assessed for hip stability in 69 children (91 femoral lengthenings) who had CFD Paley type 1a (43 children) and 1b (26 children). The mean age at first lengthening was 6.4 years...
September 27, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27666433/macrocyclization-in-the-design-of-organic-n-type-electronic-materials
#16
Melissa Ball, Yu Zhong, Brandon Fowler, Boyuan Zhang, Panpan Li, Grisha Etkin, Daniel W Paley, John Decatur, Ankur K Dalsania, Hexing Li, Shengxiong Xiao, Fay Ng, Michael L Steigerwald, Colin Nuckolls
Here, we compare analogous cyclic and acyclic π-conjugated molecules as n-type electronic materials and find that the cyclic molecules have numerous benefits in organic photovoltaics. This is the first report of such a direct comparison. We designed two conjugated cycles for this study. Each comprises four subunits: one combines four electron-accepting, redox-active, diphenyl-perylenediimide subunits, and the other alternates two electron-donating bithiophene units with two diphenyl-perylenediimide units. We compare the macrocycles to acyclic versions of these molecules and find that, relative to the acyclic analogs, the conjugated macrocycles have bathochromically shifted UV-vis absorbances and are more easily reduced...
October 5, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27642118/portrayal-of-brain-death-in-film-and-television
#17
A Lewis, J Weaver, A Caplan
We sought to evaluate whether television and cinematic coverage of brain death is educational or misleading. We identified 24 accessible productions that addressed brain death using the archives of the Paley Center for Media (160 000 titles) and the Internet Movie Database (3.7 million titles). Productions were reviewed by two board-certified neurologists. Although 19 characters were pronounced brain dead, no productions demonstrated a complete examination to assess for brain death (6 included an assessment for coma, 9 included an evaluation of at least 1 brainstem reflex, but none included an assessment of every brainstem reflex, and 2 included an apnea test)...
September 19, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27595350/orientational-order-controls-crystalline-and%C3%A2-amorphous-thermal-transport-in-superatomic%C3%A2-crystals
#18
Wee-Liat Ong, Evan S O'Brien, Patrick S M Dougherty, Daniel W Paley, C Fred Higgs Iii, Alan J H McGaughey, Jonathan A Malen, Xavier Roy
In the search for rationally assembled functional materials, superatomic crystals (SACs) have recently emerged as a unique class of compounds that combine programmable nanoscale building blocks and atomic precision. As such, they bridge traditional semiconductors, molecular solids, and nanocrystal arrays by combining their most attractive features. Here, we report the first study of thermal transport in SACs, a critical step towards their deployment as electronic, thermoelectric, and phononic materials. Using frequency domain thermoreflectance (FDTR), we measure thermal conductivity in two series of SACs: the unary compounds Co6E8(PEt3)6 (E = S, Se, Te) and the binary compounds [Co6E8(PEt3)6][C60]2...
September 5, 2016: Nature Materials
https://www.readbyqxmd.com/read/27552328/clinical-features-of-chronic-hepatitis-b-in-treatment-naive-asian-patients-with-positive-hbeag-and-coexisting-precore-and-or-basal-core-promoter-mutations
#19
Calvin Q Pan, Erhei Dai, Kalyan R Bhamidimarri, Zheng Zeng, Paley Yin
BACKGROUND: Precore or/and basal core promoter (PC/BCP) mutations are frequently detected in hepatitis B e antigen (HBeAg)-negative patients, but little is known about their clinical significance in HBeAg-positive patients. AIM: To characterize and report the clinical features of treatment-naive chronic hepatitis B patients who are HBeAg positive and harbor PC and/or BCP mutations. PATIENTS AND METHODS: Consecutive treatment-naive patients with chronic hepatitis B between 2004 and 2014 were enrolled...
August 22, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27525491/limits-of-carrier-diffusion-in-n-type-and-p-type-ch3nh3pbi3-perovskite-single-crystals
#20
Octavi E Semonin, Giselle A Elbaz, Daniel B Straus, Trevor D Hull, Daniel W Paley, Arend M van der Zande, James C Hone, Ioannis Kymissis, Cherie R Kagan, Xavier Roy, Jonathan S Owen
No abstract text is available yet for this article.
September 1, 2016: Journal of Physical Chemistry Letters
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