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https://www.readbyqxmd.com/read/28431025/1h-magnetic-resonance-spectroscopy-of-live-human-sperm
#1
S Reynolds, S J Calvert, M N Paley, A A Pacey
STUDY QUESTION: Can 1H Magnetic Resonance Spectroscopy (MRS) be used to obtain information about the molecules and metabolites in live human spermatozoa? SUMMARY ANSWER: Percoll-based density gradient centrifugation (DGC) followed by a further two washing steps, yielded enough sperm with minimal contamination (<0.01%) from seminal fluid to permit effective MRS which detected significant differences (p < 0.05) in the choline/glycerophosphocholine, lipid and lactate regions of the 1H MRS spectrum between sperm in the pellet and those from the 40/80% interface...
April 18, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28328566/physeal-and-subphyseal-distraction-osteogenesis-in-atrophic-type-congenital-pseudarthrosis-of-the-tibia-efficacy-and-safety
#2
Woo Young Jang, Yoon Hyo Choi, Moon Seok Park, Won Joon Yoo, Tae-Joon Cho, In Ho Choi
PURPOSE: To examine the efficacy, safety, and clinical outcomes of distraction osteogenesis through the physis (PDO) or through subphyseal osteotomy (SPDO) in patients with atrophic-type congenital pseudarthrosis of tibia with proximal tibial dysplasia. METHODS: To validate the efficacy and safety of PDO and SPDO, radiographic and clinical parameters were compared between 5 patients who underwent proximal tibial metaphyseal or metadiaphyseal lengthening as a control (group 1) and 7 patients who underwent PDO or SPDO (group 2)...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28242540/relation-between-chelation-and-clinical-outcomes-in-lower-risk-patients-with-myelodysplastic-syndromes-registry-analysis-at-5-years
#3
REVIEW
Roger M Lyons, Billie J Marek, Carole Paley, Jason Esposito, Katie McNamara, Paul D Richards, Nicholas DiBella, Guillermo Garcia-Manero
Prospective data are needed to ascertain the impact of iron chelation therapy in patients with myelodysplastic syndromes. The present 5-year prospective registry analysis was conducted to compare clinical outcomes between chelated and nonchelated patients with lower-risk myelodysplastic syndromes and transfusional iron overload. In an interim analysis at 24 months, we previously reported that chelation therapy was associated with longer median overall survival and a tendency toward longer leukemia-free survival and fewer cardiac events...
January 31, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28240556/unbalanced-hole-and-electron-diffusion-in-lead-bromide-perovskites
#4
Giselle A Elbaz, Daniel B Straus, Octavi E Semonin, Trevor D Hull, Daniel W Paley, Philip Kim, Jonathan S Owen, Cherie R Kagan, Xavier Roy
We use scanning photocurrent microscopy and time-resolved microwave conductivity to measure the diffusion of holes and electrons in a series of lead bromide perovskite single crystals, APbBr3, with A = methylammonium (MA), formamidinium (FA), and Cs. We find that the diffusion length of holes (LD(h+) ∼ 10-50 μm) is on average an order of magnitude longer than that of electrons (LD(e-) ∼ 1-5 μm), regardless of the A-type cation or applied bias. Furthermore, we observe a weak dependence of LD across the A-cation series MA > FA > Cs...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28236034/treatment-of-infected-non-unions-with-segmental-defects-with-a-rail-fixation-system
#5
Srikanth Mudiganty, Arup Kumar Daolagupu, Arun Kumar Sipani, Satyendra Kumar Das, Arijit Dhar, Parag Jyoti Gogoi
We conducted this study to evaluate the use of rail fixation system in infected gap non-union of femur and tibia as an alternative to the established Ilizarov circular fixator technique. Prospective study. The study was done in the Department of Orthopaedic surgery in a medical school and level I trauma center to which the authors are/were affiliated. Between June 2010 and June 2015, 40 patients with infected gap non-union of femur and tibia were treated with the rail fixation system. Patients who were willing to undergo surgery and participate in the post-operative rehabilitation were included in the study...
April 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28191664/direct-arterial-injection-of-hyperpolarized-13-c-labeled-substrates-into-rat-tumors-for-rapid-mr-detection-of-metabolism-with-minimal-substrate-dilution
#6
Steven Reynolds, Stephen Metcalf, Edward J Cochrane, Rebecca C Collins, Simon Jones, Martyn N J Paley, Gillian M Tozer
PURPOSE: A rat model was developed to enable direct administration of hyperpolarized (13) C-labeled molecules into a tumor-supplying artery for magnetic resonance spectroscopy (MRS) studies of tumor metabolism. METHODS: Rat P22 sarcomas were implanted into the right inguinal fat pad of BDIX rats such that the developing tumors received their principle blood supply directly from the right superior epigastric artery. Hyperpolarized (13) C-molecules were either infused directly to the tumor through the epigastric artery or systemically through the contralateral femoral vein...
February 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28149944/a-peek-into-the-world-behind-the-submit-button
#7
EDITORIAL
Miranda A Paley
No abstract text is available yet for this article.
January 25, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28145719/engineering-the-structural-and-electronic-phases-of-mote2-through-w-substitution
#8
D Rhodes, D A Chenet, B E Janicek, C Nyby, Y Lin, W Jin, D Edelberg, E Mannebach, N Finney, A Antony, T Schiros, T Klarr, A Mazzoni, M Chin, Y-C Chiu, W Zheng, Q R Zhang, F Ernst, J I Dadap, X Tong, J Ma, R Lou, S Wang, T Qian, H Ding, R M Osgood, D W Paley, A M Lindenberg, P Y Huang, A N Pasupathy, M Dubey, J Hone, L Balicas
MoTe2 is an exfoliable transition metal dichalcogenide (TMD) that crystallizes in three symmetries: the semiconducting trigonal-prismatic 2H- or α-phase, the semimetallic and monoclinic 1T(')- or β-phase, and the semimetallic orthorhombic γ-structure. The 2H-phase displays a band gap of ∼1 eV making it appealing for flexible and transparent optoelectronics. The γ-phase is predicted to possess unique topological properties that might lead to topologically protected nondissipative transport channels. Recently, it was argued that it is possible to locally induce phase-transformations in TMDs, through chemical doping, local heating, or electric-field to achieve ohmic contacts or to induce useful functionalities such as electronic phase-change memory elements...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28125900/geometry-of-the-valgus-knee-contradicting-the-dogma-of-a-femoral-based-deformity
#9
Helge Eberbach, Julian Mehl, Matthias J Feucht, Gerrit Bode, Norbert P Südkamp, Philipp Niemeyer
BACKGROUND: Realignment osteotomies of valgus knee deformities are usually performed at the distal femur, as valgus alignment is considered to be a femoral-based deformity. This dogma, however, has not been proven in a large patient population. Valgus malalignment may also be caused by a tibial deformity or a combined tibial and femoral deformity. PURPOSE: The purposes of this study were (1) to analyze the coronal geometry of patients with valgus malalignment and identify the location of the underlying deformity and (2) to investigate the proportion of cases that require realignment osteotomy at the tibia, the femur, or both locations to avoid an oblique joint line...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28120747/the-paley-ulnarization-of-the-carpus-with-ulnar-shortening-osteotomy-for-treatment-of-radial-club-hand
#10
Dror Paley
Recurrent deformity from centralization and radialization led to the development in 1999 of a new technique by the author called ulnarization. This method is performed through a volar approach in a vascular and physeal sparing fashion. It biomechanically balances the muscle forces on the wrist by dorsally transferring the flexor carpi ulnaris (FCU) from a deforming to a corrective force. The previous problems of a prominent bump from the ulnar head and ulnar deviation instability were solved by acutely shortening the diaphysis and by temporarily fixing the station of the carpus to the ulnar head at the level of the scaphoid...
2017: SICOT-J
https://www.readbyqxmd.com/read/28118202/from-mechanism-to-therapies-in-systemic-lupus-erythematosus
#11
Michael A Paley, Vibeke Strand, Alfred H J Kim
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a disabling and deadly disease. Development of novel therapies for SLE has historically been limited by incomplete understanding of immune dysregulation. Recent advances in lupus pathogenesis, however, have led to the adoption or development of new therapeutics, including the first Food and Drug Administration-approved drug in 50 years. RECENT FINDINGS: Multiple cytokines (interferon, B lymphocyte stimulator, IL-6, and IL-17), signaling pathways (Bruton's Tyrosine Kinase, Janus kinase/signal transducer and activator of transcription), and immune cells are dysregulated in SLE...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28106389/orthogonal-luciferase-luciferin-pairs-for-bioluminescence-imaging
#12
Krysten A Jones, William B Porterfield, Colin M Rathbun, David C McCutcheon, Miranda A Paley, Jennifer A Prescher
Bioluminescence imaging with luciferase-luciferin pairs is widely used in biomedical research. Several luciferases have been identified in nature, and many have been adapted for tracking cells in whole animals. Unfortunately, the optimal luciferases for imaging in vivo utilize the same substrate and therefore cannot easily differentiate multiple cell types in a single subject. To develop a broader set of distinguishable probes, we crafted custom luciferins that can be selectively processed by engineered luciferases...
February 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28058273/a-season-of-giving-to-science
#13
EDITORIAL
Carolyn R Bertozzi, Miranda A Paley
No abstract text is available yet for this article.
December 28, 2016: ACS Central Science
https://www.readbyqxmd.com/read/27964719/pathway-collages-personalized-multi-pathway-diagrams
#14
Suzanne Paley, Paul E O'Maille, Daniel Weaver, Peter D Karp
BACKGROUND: Metabolic pathway diagrams are a classical way of visualizing a linked cascade of biochemical reactions. However, to understand some biochemical situations, viewing a single pathway is insufficient, whereas viewing the entire metabolic network results in information overload. How do we enable scientists to rapidly construct personalized multi-pathway diagrams that depict a desired collection of interacting pathways that emphasize particular pathway interactions? RESULTS: We define software for constructing personalized multi-pathway diagrams called pathway-collages using a combination of manual and automatic layouts...
December 13, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27933259/deformity-correction-and-extremity-lengthening-in-the-lower-leg-comparison-of-clinical-outcomes-with-two-external-surgical-procedures
#15
Eugen Reitenbach, Robert Rödl, Georg Gosheger, Björn Vogt, Frank Schiedel
OBJECTIVE: Distraction osteogenesis is a method of stimulating the growth of new bone tissue in order to lengthen the extremities or bridge resected bone defects. In addition to the now-established intramedullary procedures, two different fixator systems are in use. The present study investigated the classical Ilizarov ring fixator (IRF) and a hexapod to assess the precision of lower-leg lengthening and complications classified using the Paley criteria for problems, obstacles, and complications...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27909861/surgical-reconstruction-for-fibular-hemimelia
#16
REVIEW
Dror Paley
Fibular hemimelia presents with foot deformity and leg length discrepancy. Previous classifications have focused on the degree of fibular deficiency rather than the type of foot deformity. Published methods of surgical reconstruction have often failed due to residual or recurrent foot deformity. The purpose of this report is to introduce new classification and reconstruction methods. The Paley SHORDT procedure is used to stabilize the ankle when there is a hypoplastic distal fibula with a dynamic valgus deformity...
December 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27909860/tibial-hemimelia-new-classification-and-reconstructive-options
#17
REVIEW
Dror Paley
Tibial hemimelia is a rare congenital lower limb deficiency presenting with a wide spectrum of associated congenital anomalies, deficiencies and duplications. Reconstructive options have been limited, and the gold standard for treatment has remained amputation with prosthetic fitting. There is now a better understanding of the genetics, etiology and pathoanatomy of tibial hemimelia. Armed with this knowledge, I present here a new classification to guide treatment and prognosis and then discuss new treatment strategies and techniques for limb reconstruction based on this new classification scheme...
December 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27907996/probabilistic-information-transmission-in-a-network-of-coupled-oscillators-reveals-speed-accuracy-trade-off-in-responding-to-threats
#18
Amanda Chicoli, Derek A Paley
Individuals in a group may obtain information from other group members about the environment, including the location of a food source or the presence of a predator. Here, we model how information spreads in a group using a susceptible-infected-removed epidemic model. We apply this model to a simulated shoal of fish using the motion dynamics of a coupled oscillator model, in order to test the biological hypothesis that polarized or aligned shoaling leads to faster and more accurate escape responses. The contributions of this study are the (i) application of a probabilistic model of epidemics to the study of collective animal behavior; (ii) testing the biological hypothesis that group cohesion improves predator escape; (iii) quantification of the effect of social cues on startle propagation; and (iv) investigation of the variation in response based on network connectivity...
November 2016: Chaos
https://www.readbyqxmd.com/read/27899573/the-ecocyc-database-reflecting-new-knowledge-about-escherichia-coli-k-12
#19
Ingrid M Keseler, Amanda Mackie, Alberto Santos-Zavaleta, Richard Billington, César Bonavides-Martínez, Ron Caspi, Carol Fulcher, Socorro Gama-Castro, Anamika Kothari, Markus Krummenacker, Mario Latendresse, Luis Muñiz-Rascado, Quang Ong, Suzanne Paley, Martin Peralta-Gil, Pallavi Subhraveti, David A Velázquez-Ramírez, Daniel Weaver, Julio Collado-Vides, Ian Paulsen, Peter D Karp
EcoCyc (EcoCyc.org) is a freely accessible, comprehensive database that collects and summarizes experimental data for Escherichia coli K-12, the best-studied bacterial model organism. New experimental discoveries about gene products, their function and regulation, new metabolic pathways, enzymes and cofactors are regularly added to EcoCyc. New SmartTable tools allow users to browse collections of related EcoCyc content. SmartTables can also serve as repositories for user- or curator-generated lists. EcoCyc now supports running and modifying E...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27892743/muscle-strength-and-knee-range-of-motion-after-femoral-lengthening
#20
Anil Bhave, Lior Shabtai, Erik Woelber, Arman Apelyan, Dror Paley, John E Herzenberg
Background and purpose - Femoral lengthening may result in decrease in knee range of motion (ROM) and quadriceps and hamstring muscle weakness. We evaluated preoperative and postoperative knee ROM, hamstring muscle strength, and quadriceps muscle strength in a diverse group of patients undergoing femoral lengthening. We hypothesized that lengthening would not result in a significant change in knee ROM or muscle strength. Patients and methods - This prospective study of 48 patients (mean age 27 (9-60) years) compared ROM and muscle strength before and after femoral lengthening...
April 2017: Acta Orthopaedica
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