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https://www.readbyqxmd.com/read/27902776/inhibition-of-candida-albicans-biofilm-formation-by-the-synthetic-lactoferricin-derived-peptide-hlf1-11
#1
Paola Morici, Roberta Fais, Cosmeri Rizzato, Arianna Tavanti, Antonella Lupetti
The aim of this study was to evaluate the in vitro activity of the synthetic peptide hLF1-11 against biofilm produced by clinical isolates of Candida albicans with different fluconazole susceptibility. The antibiofilm activity of the peptide hLF1-11 was assessed in terms of reduction of biofilm cellular density, metabolic activity and sessile cell viability. The extent of morphogenesis in hLF1-11 treated and untreated biofilms was also investigated microscopically. Transcription levels of genes related to cell adhesion, hyphal development and extracellular matrix production were analysed by qRT-PCR in hLF1-11 treated and untreated biofilms...
2016: PloS One
https://www.readbyqxmd.com/read/27890003/biofilm-mediated-antibiotic-resistant-oral-bacterial
#2
Indu Lata Kanwar, Abhishek Kumar Sah, Preeti K Suresh
Oral diseases like dental caries and periodontal disease are directly associated with the capability of bacteria to form biofilm. Periodontal diseases have been associated to anaerobic Gram-negative bacteria forming a subgingival plaque (Porphyromonas gingivalis, Actinobacillus, Prevotella and Fusobacterium). Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. Biofilm communities are the causative agents of biological developments such as dental caries, periodontitis, and peri-implantitis, and causing periodontal tissue breakdown...
November 24, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27872845/recent-nanotechnology-approaches-for-prevention-and-treatment-of-biofilm-associated-infections-on-medical-devices
#3
REVIEW
Mohankandhasamy Ramasamy, Jintae Lee
Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. There is an urgent need for novel antimicrobial or antibiofilm surfaces and biomedical devices that provide protection against biofilm formation and planktonic pathogens, including antibiotic resistant strains. In this context, recent developments in the material science and engineering fields and steady progress in the nanotechnology field have created opportunities to design new biomaterials and surfaces with anti-infective, antifouling, bactericidal, and antibiofilm properties...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27864804/activity-of-norspermidine-on-bacterial-biofilms-of-multidrug-resistant-clinical-isolates-associated-with-persistent-extremity-wound-infections
#4
Anthony P Cardile, Ronald L Woodbury, Carlos J Sanchez, Sandra C Becerra, Rebecca A Garcia, Katrin Mende, Joseph C Wenke, Kevin S Akers
Biofilm formation is a major virulence factor for numerous pathogenic bacteria and is cited as a central event in the pathogenesis of chronic human infections, which is in large part due to excessive extracellular matrix secretion and metabolic changes that occur within the biofilm rendering them highly tolerant to antimicrobial treatments. Polyamines, including norspermidine, play central roles in bacterial biofilm development, but have also recently been shown to inhibit biofilm formation in select strains of various pathogenic bacteria...
November 19, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27864779/activity-of-novel-inhibitors-of-staphylococcus-aureus-biofilms
#5
Seung-Gyun Woo, So-Yeon Lee, So-Min Lee, Kyoung-Hee Lim, Eun-Ju Ha, Yong-Bin Eom
Staphylococcus aureus is one of the most important pathogens causing chronic biofilm infections. These are becoming more difficult to treat owing to drug resistance, particularly because S. aureus biofilms limit the efficacy of antimicrobial agents, leading to high morbidity and mortality. In the present study, we screened for inhibitors of S. aureus biofilm formation using a natural product library from the Korea Chemical Bank (KCB). Screening by crystal violet-based biomass staining assay identified hit compounds...
November 18, 2016: Folia Microbiologica
https://www.readbyqxmd.com/read/27862685/topical-application-of-probiotics-in-skin-adhesion-antimicrobial-and-antibiofilm-in-vitro-assays
#6
Elísia G Lopes, Diana A Moreira, Patricia Gullón, Beatriz Gullón, Alejandra Cardelle-Cobas, Freni K Tavaria
AIMS: When skin dysbiosis occurs as a result of skin disorders, probiotics can act as modulators, restoring microbial balance. Several properties of selected probiotics were evaluated so that their topical application could be considered. METHODS AND RESULTS: Adhesion, antimicrobial, quorum sensing and antibiofilm assays were carried out with several probiotic strains and tested against selected skin pathogens. All tested strains displayed significant adhesion to keratin...
November 12, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27856967/nanosized-building-blocks-for-customizing-novel-antibiofilm-approaches
#7
A J Paula, H Koo
Recent advances in nanotechnology provide unparalleled flexibility to control the composition, size, shape, surface chemistry, and functionality of materials. Currently available engineering approaches allow precise synthesis of nanocompounds (e.g., nanoparticles, nanostructures, nanocrystals) with both top-down and bottom-up design principles at the submicron level. In this context, these "nanoelements" (NEs) or "nanosized building blocks" can 1) generate new nanocomposites with antibiofilm properties or 2) be used to coat existing surfaces (e...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856271/antimicrobial-antitrypanosomal-and-antibiofilm-activity-of-equisetum-hyemale
#8
Camilla Filippi Dos Santos Alves, Pauline Cordenonsi Bonez, Marcia de Ebling de Souza, Ritiel Corrêa da Cruz, Aline Augusti Boligon, Mariana Piana, Thiele Facim Brum, Grazielle Guidolin Rossi, Roberta da Silva Jesus, Thirssa Helena Grando, Silvia Gonzalez Monteiro, Marli Matiko Anraku de Campos, Janice Luering Giongo, Roberto Christ Vianna Santos
This study evaluates, for the first time, the antibiofilm, antimicrobial and antiparasitic potential of crude extract and fractions of stems of Equisetum hyemale against several infectious agents (bacteria, fungi, Mycobacterium and Trypanosomes) by broth microdilution technique and investigates the phenolic composition of the plant by high performance liquid chromatography. The crude extract and fractions showed antimicrobial activity, as they were capable of inhibiting the growth of bacteria in minimal inhibitory concentrations (MICs) ranging from 52...
November 14, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27845276/3d-scaffold-with-effective-multidrug-sequential-release-against-bacteria-biofilm
#9
Rafaela García-Alvarez, Isabel Izquierdo-Barba, María Vallet-Regí
Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous regeneration and local multidrug therapy so as to avoid bacterial growth, drug resistance and the feared side effects. Herein, hierarchical 3D multidrug scaffolds based on nanocomposite bioceramic and polyvinyl alcohol (PVA) prepared by rapid prototyping with an external coating of gelatin-glutaraldehyde (Gel-Glu) have been fabricated...
November 11, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27836851/the-behavior-of-staphylococcus-aureus-dual-species-biofilms-treated-with-bacteriophage-phiipla-rodi-depends-on-the-accompanying-microorganism
#10
Silvia González, Lucía Fernández, Ana Belén Campelo, Diana Gutiérrez, Beatriz Martínez, Ana Rodríguez, Pilar García
: The use of bacteriophages as antimicrobials against pathogenic bacteria offers a promising alternative to traditional antibiotics and disinfectants. Significantly, phages may help to remove biofilms, which are notoriously resistant to commonly used eradication methods. However, the successful development of novel antibiofilm strategies must take into account that real-life biofilms usually consist of mixed-species populations. Within this context, this study aimed to explore the effectiveness of bacteriophage-based sanitation procedures for removing polymicrobial biofilms from food industry surfaces...
November 11, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27836761/effect-of-holarrhena-antidysentrica-ha-and-andrographis-paniculata-ap-on-the-biofilm-formation-and-cell-membrane-integrity-of-opportunistic-pathogen-salmonella-typhimurium
#11
Ankit Tanwar, Raman Chawla, Ankita Singh Chakotiya, Pallavi Thakur, Rajeev Goel, Mitra Basu, Rajesh Arora, Haider Ali Khan
Increasing occurrence of gastroenteritis outbreaks caused by food borne opportunistic microorganisms has become a major problem in food industry as well as in immunocompromised host. Antimicrobial agents are losing their efficacy due to increase in the microbial resistance. For such reasons, conventional treatment has become limited to manage the infections state. Need of the hour is to instigate the search for safer holistic alternatives. The present study was hence conducted to assess the antibiofilm effect and mode of action of aquo alcoholic extracts of Holarrhena antidysentrica (Ha) and Andrographis paniculata (Ap) against the Salmonella enterica serovar typhimurium...
November 9, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27815925/microbiological-diagnosis-of-implant-related-infections-scientific-evidence-and-cost-benefit-analysis-of-routine-antibiofilm-processing
#12
Lorenzo Drago, Elena De Vecchi
Prosthetic joint infection is one of the most severe complication following joint arthroplasty, producing a significant worsening of patient's quality of life. Management of PJIs requires extended courses of antimicrobial therapy, multiple surgical interventions and prolonged hospital stay, with a consequent economic burden, which is thought to markedly increase in the next years due to the expected burden in total joint arthroplasties. The present review summarizes the present knowledge on microbiological diagnosis of prosthetic joint infections, focusing on aethiological agents and discussing pros and cons of the available strategies for their diagnosis...
November 5, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27815202/haemolytic-and-antibiofilm-properties-of-haemocyanin-purified-from-the-haemolymph-of-indian-white-shrimp-fenneropenaeus-indicus
#13
Ramachandran Ishwarya, Baskaralingam Vaseeharan, Arokiadhas Iswarya, Sivashanmugam Karthikeyan
Haemocyanin (Hc) is an important non-specific immune macromolecule present in the haemolymph of both mollusks and crustaceans. In the present study, Hc was purified from the haemolymph of Indian white shrimp Fenneropenaeus indicus by gel filtration chromatography and it exhibits a single band with a molecular weight of 74 kDa on SDS-PAGE. The X-ray diffraction (XRD) and High performance liquid chromatography (HPLC) result of purified Hc express single peak at 31.5° be a sign of crystalline nature and appear as a single peak with a retention time of 5...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27813824/enhanced-production-of-poly-3-hydroxybutyrate-co-4-hydroxybutyrate-copolymer-and-antimicrobial-yellow-pigmentation-from-cupriavidus-sp-usmahm13-with-anti-biofilm-capability
#14
Iszatty Ismail, Tana Poorani Gurusamy, Hema Ramachandran, Amirul Al-Ashraf Abdullah
Anti-biofilm polymers have the ability to inhibit bacterial biofilm formation, which is known to occur ubiquitously in the environment and pose risks of infection. In this study, production of P(3HB-co-4HB) copolymer and antimicrobial yellow pigment from Cupriavidus sp. USMAHM13 are enhanced via medium optimization. Prior to the improvement of yellow pigment production, screening for the best additional supplement was performed resulting in high-yield yellow pigmentation using yeast extract with optimum concentration of 2 g/L...
November 4, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27812802/biotechnological-potential-of-actinobacteria-from-canadian-and-azorean-volcanic-caves
#15
Cristina Riquelme, Maria de Lurdes Enes Dapkevicius, Ana Z Miller, Zachary Charlop-Powers, Sean Brady, Cohord Mason, Naowarat Cheeptham
Caves are regarded as extreme habitats with appropriate conditions for the development of Actinobacteria. In comparison with other habitats, caves have not yet been the target of intensive screening for bioactive secondary metabolites produced by actinomycetes. As a primary screening strategy, we conducted a metagenomic analysis of the diversity and richness of a key gene required for non-ribosomal peptide (NRP) biosynthesis, focusing on cave-derived sediments from two Canadian caves (a lava tube and a limestone cave) to help us predict whether different types of caves may harbor drug-producing actinobacteria...
November 3, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27809517/antibacterial-and-antibiofilm-activity-of-cationic-small-molecules-with-spatial-positioning-of-hydrophobicity-an-in-vitro-and-in-vivo-evaluation
#16
Jiaul Hoque, Mohini Mohan Konai, Shanola Smitha Sequeira, Sandip Samaddar, Jayanta Haldar
More than 80% of the bacterial infections are associated with biofilm formation. To combat infections, amphiphilic small molecules have been developed as promising antibiofilm agents. However, cytotoxicity of such molecules still remains a major problem. Herein we demonstrate a concept in which antibacterial versus cytotoxic activities of cationic small molecules is tuned by spatial positioning of hydrophobic moieties while keeping positive charges constant. Compared to the molecules with more pendent hydrophobicity from positive centres (MIC = 1-4 μg/mL and HC50 = 60-65 μg/mL), molecules with more confined hydrophobicity between two centres show similar antibacterial activity but significantly less toxicity towards human erythrocytes (MIC = 1-4 μg/mL and HC50 = 805-1242 μg/mL)...
November 4, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27808174/essential-oils-and-eugenols-inhibit-biofilm-formation-and-the-virulence-of-escherichia-coli-o157-h7
#17
Yong-Guy Kim, Jin-Hyung Lee, Giyeon Gwon, Soon-Il Kim, Jae Gyu Park, Jintae Lee
Enterohemorrhagic Escherichia coli O157:H7 (EHEC) has caused foodborne outbreaks worldwide and the bacterium forms antimicrobial-tolerant biofilms. We investigated the abilities of various plant essential oils and their components to inhibit biofilm formation by EHEC. Bay, clove, pimento berry oils and their major common constituent eugenol at 0.005% (v/v) were found to markedly inhibit EHEC biofilm formation without affecting planktonic cell growth. In addition, three other eugenol derivatives isoeugenol, 2-methoxy-4-propylphenol, and 4-ethylguaiacol had antibiofilm activity, indicating that the C-1 hydroxyl unit, the C-2 methoxy unit, and C-4 alkyl or alkane chain on the benzene ring of eugenol play important roles in antibiofilm activity...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27787755/antimicrobial-peptide-isolated-from-bacillus-amyloliquefaciens-k14-revitalizes-its-use-in-combinatorial-drug-therapy
#18
Sudip Regmi, Yun Hee Choi, Yoon Seok Choi, Mi Ri Kim, Jin Cheol Yoo
The present study was performed to evaluate the antibacterial activities of an antimicrobial peptide (CSpK14) and the synergies thereof with β-lactams against vancomycin-resistant Staphylococcus aureus (VRSA) and Enterococci (VRE). Our strain was isolated from fermented food (kimchi), which is 99.79 % homologous with Bacillus amyloliquefaciens subsp. plantarum FZB42(T). CSpK14 was purified to homogeneity by diammonium sulfate precipitation, concentration, dialysis, and followed by two-stage chromatographic separation, i...
October 27, 2016: Folia Microbiologica
https://www.readbyqxmd.com/read/27776882/zinc-oxide-nanoparticles-enhance-physicochemical-characteristics-of-grossman-sealer
#19
Marco Aurélio Versiani, Fuad Jacob Abi Rached-Junior, Anil Kishen, Jesus Djalma Pécora, Yara Terezinha Silva-Sousa, Manoel Damião de Sousa-Neto
INTRODUCTION: Metallic antibacterial nanoparticles have been shown to provide distinct antibacterial advantage and antibiofilm efficacy when applied in infected root canals. The purpose of this study was to evaluate the influence of incorporating zinc oxide nanoparticles (ZnO-Np) on the physicochemical properties of Grossman sealer. METHODS: Grossman sealer was prepared according to its original formula. Additionally, 4 experimental sealers were prepared by replacing the zinc oxide component of the powder with ZnO-Np (average size of 20 nm) in different amounts (25%, 50%, 75%, and 100%)...
October 21, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27766027/capping-agent-dependent-toxicity-and-antimicrobial-activity-of-silver-nanoparticles-an-in-vitro-study-concerns-about-potential-application-in-dental-practice
#20
Karolina Niska, Narcyz Knap, Anna Kędzia, Maciej Jaskiewicz, Wojciech Kamysz, Iwona Inkielewicz-Stepniak
Objectives: In dentistry, silver nanoparticles (AgNPs) have drawn particular attention because of their wide antimicrobial activity spectrum. However, controversial information on AgNPs toxicity limited their use in oral infections. Therefore, the aim of the present study was to evaluate the antibacterial activities against a panel of oral pathogenic bacteria and bacterial biofilms together with potential cytotoxic effects on human gingival fibroblasts of 10 nm AgNPs: non-functionalized - uncapped (AgNPs-UC) as well as surface-functionalized with capping agent: lipoic acid (AgNPs-LA), polyethylene glycol (AgNPs-PEG) or tannic acid (AgNPs-TA) using silver nitrate (AgNO3) as control...
2016: International Journal of Medical Sciences
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