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https://www.readbyqxmd.com/read/29329652/three-new-anthraquinone-derivatives-isolated-from-symplocos-racemosa-and-their-antibiofilm-activity
#1
Umar Farooq, Sara Khan, Sadia Naz, Ajmal Khan, Afsar Khan, Ayaz Ahmed, Abdur Rauf, Syed Majid Bukhari, Shujaat Ali Khan, Arfa Kamil, Nadia Riaz, Abdur Rahman Khan
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, 1H- and 13C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL-1 against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29326076/phage-derived-lysins-as-potential-agents-for-eradicating-biofilms-and-persisters
#2
REVIEW
Umender Sharma, Aradhana Vipra, Shankaramurthy Channabasappa
Bacterial biofilms are highly resistant to the action of antibiotics. Presence of persisters, phenotypically resistant populations of bacterial cells, is thought to contribute toward recalcitrance of biofilms. The phage-derived lysins, by virtue of their ability to cleave the peptidoglycan of bacterial cells in an enzymatic manner, have the unique ability to kill dormant cells. Several lysins have shown potent antibiofilm activity in vitro. The fact that lysins have shown better efficacy than conventional drugs in animal models of endocarditis and other infections involving biofilms suggests that the lysins can potentially be developed against difficult-to-treat bacterial infections...
January 8, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29321257/the-antimicrobial-peptide-saap-148-combats-drug-resistant-bacteria-and-biofilms
#3
Anna de Breij, Martijn Riool, Robert A Cordfunke, Nermina Malanovic, Leonie de Boer, Roman I Koning, Elisabeth Ravensbergen, Marnix Franken, Tobias van der Heijde, Bouke K Boekema, Paulus H S Kwakman, Niels Kamp, Abdelouahab El Ghalbzouri, Karl Lohner, Sebastian A J Zaat, Jan W Drijfhout, Peter H Nibbering
Development of novel antimicrobial agents is a top priority in the fight against multidrug-resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial and antibiofilm peptides (SAAPs) with enhanced antimicrobial activities compared to the parent peptide, human antimicrobial peptide LL-37. Our lead peptide SAAP-148 was more efficient in killing bacteria under physiological conditions in vitro than many known preclinical- and clinical-phase antimicrobial peptides. SAAP-148 killed MDR pathogens without inducing resistance, prevented biofilm formation, and eliminated established biofilms and persister cells...
January 10, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#4
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29320462/unsaturated-fatty-acids-affect-quorum-sensing-communication-system-and-inhibit-motility-and-biofilm-formation-of-acinetobacter-baumannii
#5
Marion Nicol, Stéphane Alexandre, Jean-Baptiste Luizet, Malena Skogman, Thierry Jouenne, Suzana P Salcedo, Emmanuelle Dé
The increasing threat of Acinetobacter baumannii as a nosocomial pathogen is mainly due to the occurrence of multidrug-resistant strains that are associated with the real problem of its eradication from hospital wards. The particular ability of this pathogen to form biofilms contributes to its persistence, increases antibiotic resistance, and promotes persistent/device-related infections. We previously demonstrated that virstatin, which is a small organic compound known to decrease virulence of Vibrio cholera via an inhibition of T4-pili expression, displayed very promising activity to prevent A...
January 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29317719/application-of-rotating-magnetic-fields-increase-the-activity-of-antimicrobials-against-wound-biofilm-pathogens
#6
A F Junka, R Rakoczy, P Szymczyk, M Bartoszewicz, P P Sedghizadeh, K Fijałkowski
Infective complications are a major factor contributing to wound chronicity and can be associated with significant morbidity or mortality. Wound bacteria are protected in biofilm communities and are highly resistant to immune system components and to antimicrobials used in wound therapy. There is an urgent medical need to more effectively eradicate wound biofilm pathogens. In the present work, we tested the impact of such commonly used antibiotics and antiseptics as gentamycin, ciprofloxacin, octenidine, chlorhexidine, polihexanidine, and ethacridine lactate delivered to Staphylococcus aureus and Pseudomonas aeruginosa biofilms in the presence of rotating magnetic fields (RMFs) of 10-50 Hz frequency and produced by a customized RMF generator...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316223/probiotic-lactobacillus-sp-inhibit-growth-biofilm-formation-and-gene-expression-of-caries-inducing-streptococcus-mutans
#7
Reham Wasfi, Ola A Abd El-Rahman, Mai M Zafer, Hossam M Ashour
Streptococcus mutans contributes significantly to dental caries, which arises from homoeostasic imbalance between host and microbiota. We hypothesized that Lactobacillus sp. inhibits growth, biofilm formation and gene expression of Streptococcus mutans. Antibacterial (agar diffusion method) and antibiofilm (crystal violet assay) characteristics of probiotic Lacobacillus sp. against Streptococcus mutans (ATCC 25175) were evaluated. We investigated whether Lacobacillus casei (ATCC 393), Lactobacillus reuteri (ATCC 23272), Lactobacillus plantarum (ATCC 14917) or Lactobacillus salivarius (ATCC 11741) inhibit expression of Streptococcus mutans genes involved in biofilm formation, quorum sensing or stress survival using quantitative real-time polymerase chain reaction (qPCR)...
January 8, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29313670/layer-by-layer-decorated-nanoparticles-with-tunable-antibacterial-and-antibiofilm-properties-against-both-gram-positive-and-gram-negative-bacteria
#8
Aleksandra Ivanova, Kristina Ivanova, Javier Hoyo, Thomas Heinze, Susana Sanchez-Gomez, Tzanko Tzanov
Bacteria-mediated diseases are a global healthcare concern due to the development and spread of antibiotic resistant strains. Cationic compounds are considered membrane active biocidal agents having a great potential to control bacterial infections, while limiting the emergence of drug resistance. Herein, the versatile and simple Layer-by-Layer (LbL) technique was used to coat alternating multilayers of an antibacterial aminocellulose conjugate and the biocompatible hyaluronic acid on biocompatible polymer nanoparticles (NPs), taking advantage of the nano-size of these otherwise biologically inert templates...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29305985/mechanistic-studies-of-the-antibiofilm-activity-and-synergy-with-antibiotics-of-isosorbide-mononitrate
#9
Sayeed Hasan, Yassamin N S Albayaty, Benjamin Thierry, Clive A Prestidge, Nicky Thomas
The use of nitric oxide (NO), a naturally occurring antimicrobial agent, as an alternative strategy to combat bacterial biofilms has recently gained considerable momentum in light of the global threat of emerging antibiotic resistance. While previous NO-based anti-biofilm approaches were aimed at killing bacteria cells within biofilms, NO has also been recently identified as a key mediator of biofilm dispersal, causing the release of cells from the biofilm community. This is of great interest towards the design of more effective anti-biofilm strategies but further studies are warranted to validate this concept...
January 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29301331/antimicrobial-and-antibiofilm-activity-of-up-5-an-ultrashort-antimicrobial-peptide-designed-using-only-arginine-and-biphenylalanine
#10
Ammar Almaaytah, Mohammed T Qaoud, Gubran Khalil Mohammed, Ahmad Abualhaijaa, Daniel Knappe, Ralf Hoffmann, Qosay Al-Balas
The recent upsurge of multidrug resistant bacteria (MDRB) among global communities has become one of the most serious challenges facing health professionals and the human population worldwide. Cationic ultrashort antimicrobial peptides (USAMPs) are a promising group of molecules that meet the required criteria of novel antimicrobial drug development. UP-5, a novel penta-peptide, displayed significant antimicrobial activities against various standard and clinical isolates of MDRB. UP-5 displayed MICs values within the range of (10-15 μM) and (55-65 μM) against Gram-positive and Gram-negative bacteria, respectively...
January 2, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29296084/development-and-characterization-of-p1025-loaded-bioadhesive-liquid-crystalline-system-for-the-prevention-of-streptococcus-mutans-biofilms
#11
Giovana Maria Fioramonti Calixto, Cristiane Duque, Kelly Limi Aida, Vanessa Rodrigues Dos Santos, Loiane Massunari, Marlus Chorilli
Formation of a dental biofilm by Streptococcus mutans can cause dental caries, and remains a costly health problem worldwide. Recently, there has been a growing interest in the use of peptidic drugs, such as peptide p1025, analogous to the fragments 1025-1044 of S. mutans cellular adhesin, responsible for the adhesion and formation of dental biofilm. However, peptides have physicochemical characteristics that may affect their biological action, limiting their clinical performance. Therefore, drug-delivery systems, such as a bioadhesive liquid-crystalline system (LCS), may be attractive strategies for peptide delivery...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29290510/effect-of-nano-silver-nano-copper-deconex-and-benzalkonium-chloride-on-biofilm-formation-and-expression-of-transcription-regulatory-quorum-sensing-gene-rh1r-in-drug-resistance-pseudomonas-aeruginosa-burn-isolates
#12
Melika Gholamrezazadeh, Mohammad Reza Shakibaie, Fatemeh Monirzadeh, Shalaleh Masoumi, Zahra Hashemizadeh
BACKGROUND: Biofilm forming drug-resistant Pseudomonas aeruginosa are responsible for major death in burn center of different hospitals across the globe. OBJECTIVE: The aims of this study were to evaluate the effect of nano-silver (Ag), nano-copper (Cu), and two hospital disinfectants (deconex and benzalkonium chloride) on biofilm formation and expression of transcription regulatory quorum sensing gene rh1R in P. aeruginosa burn isolates. METHODS: 28 multidrug-resistant P...
December 28, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29288300/biogenic-synthesis-of-silver-nanoparticles-using-piper-betle-aqueous-extract-and-evaluation-of-its-anti-quorum-sensing-and-antibiofilm-potential-against-uropathogens-with-cytotoxic-effects-an-in-vitro-and-in-vivo-approach
#13
Ramanathan Srinivasan, Loganathan Vigneshwari, Tamilselvam Rajavel, Ravindran Durgadevi, Arunachalam Kannappan, Krishnaswamy Balamurugan, Kasi Pandima Devi, Arumugam Veera Ravi
Urinary tract infections are the utmost common bacterial infections caused by Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, and Serratia marcescens. These uropathogens resist the action of several antibiotics due to their ability to form biofilms. Most of these bacterial pathogens use the quorum sensing (QS) machinery to co-ordinate their cells and regulate several virulence factors and biofilm formation. On the other hand, the anti-quorum sensing (anti-QS) and antibiofilm potential of silver nanoparticles have been well reported against certain bacterial pathogens, but to the best of our knowledge, no report is available against the pathogenicity of uropathogens in particular S...
December 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29280609/new-perspectives-in-biofilm-eradication
#14
Heidi Wolfmeier, Daniel Pletzer, Sarah C Mansour, Robert E W Hancock
Microbial biofilms, which are elaborate and highly resistant microbial aggregates formed on surfaces or medical devices, cause two-thirds of infections and constitute a serious threat to public health. Immunocompromised patients, individuals who require implanted devices, artificial limbs, organ transplants, or external life support and those with major injuries or burns, are particularly prone to become infected. Antibiotics, the mainstay treatments of bacterial infections, have often proven ineffective in the fight against microbes when growing as biofilms, and to date, no antibiotic has been developed for use against biofilm infections...
December 27, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29280044/hydrogels-containing-antibiofilm-and-antimicrobial-agents-beneficial-for-biofilm-associated-wound-infection-formulation-characterizations-and-in-vitro-study
#15
Anam Anjum, Cai-Hong Sim, Shiow-Fern Ng
Bacterial biofilm which adheres onto wound surface is shown to be impervious to antibiotics and this in turn delays wound healing. Previous studies showed that antibiofilm agents such as xylitol and ethylenediaminetetraacetic acid (EDTA) prevent bacterial adherence onto surfaces. Formulation of a wound dressing containing antibiofilm agents may be a plausible strategy in breaking the biofilm on wound surfaces and at the same time increase the efficacy of the antibiotic. The purpose of this study was to develop hydrogel formulations containing antibiofilm agents along with antibiotic (gentamicin) for bacterial biofilm-associated wound infection...
December 26, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29276503/synergistic-antimicrobial-interaction-between-honey-and-phage-against-escherichia-coli-biofilms
#16
Ana Oliveira, Henrique G Ribeiro, Ana C Silva, Maria D Silva, Jessica C Sousa, Célia F Rodrigues, Luís D R Melo, Ana F Henriques, Sanna Sillankorva
Chronic wounds afford a hostile environment of damaged tissues that allow bacterial proliferation and further wound colonization. Escherichia coli is among the most common colonizers of infected wounds and it is a prolific biofilm former. Living in biofilm communities, cells are protected, become more difficult to control and eradicate, and less susceptible to antibiotic therapy. This work presents insights into the proceedings triggering E. coli biofilm control with phage, honey, and their combination, achieved through standard antimicrobial activity assays, zeta potential and flow cytometry studies and further visual insights sought by scanning electron microscopy and transmission electron microscopy...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29273737/hydrolytic-activity-determination-of-tail-tubular-protein-a-of-klebsiella-pneumoniae-bacteriophages-towards-saccharide-substrates
#17
Ewa Brzozowska, Anna Pyra, Krzysztof Pawlik, Monika Janik, Sabina Górska, Natalia Urbańska, Zuzanna Drulis-Kawa, Andrzej Gamian
In this paper, the enzymatic activity, substrate specificity and antibiofilm feature of bacteriophage dual-function tail proteins are presented. So far, tail tubular proteins A-TTPAgp31 and TTPAgp44-have been considered as structural proteins of Klebsiella pneumoniae bacteriophages KP32 and KP34, respectively. Our results show that TTPAgp31 is able to hydrolyze maltose as well as Red-starch. The activity of 1 µM of the protein was calculated as 47.6 milli-Units/assay relating to the α-amylase activity. It degrades capsular polysaccharides (cPS), slime polysaccharides (sPS) and lipopolysaccharide (LPS) of K...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29259923/exploring-the-anti-quorum-sensing-and-antibiofilm-efficacy-of-phytol-against-serratia-marcescens-associated-acute-pyelonephritis-infection-in-wistar-rats
#18
Ramanathan Srinivasan, Ramar Mohankumar, Arunachalam Kannappan, Veeramani Karthick Raja, Govindaraju Archunan, Shunmugiah Karutha Pandian, Kandasamy Ruckmani, Arumugam Veera Ravi
Quorum Sensing (QS) mechanism, a bacterial density-dependent gene expression system, governs the Serratia marcescens pathogenesis through the production of virulence factors and biofilm formation. The present study demonstrates the anti-quorum sensing (anti-QS), antibiofilm potential and in vivo protective effect of phytol, a diterpene alcohol broadly utilized as food additive and in therapeutics fields. In vitro treatment of phytol (5 and 10 μg/ml) showed decreasing level of biofilm formation, lipase and hemolysin production in S...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29251486/branched-high-molecular-weight-glyco-polypeptide-with-broad-spectrum-antimicrobial-activity-for-the-treatment-of-biofilm-related-infections
#19
Nicolò Mauro, Domenico Schillaci, Paola Varvarà, Maria Grazia Cusimano, Daniela Maria Geraci, Mario Giuffrè, Gennara Cavallaro, Carmelo Massimo Maida, Gaetano Giammona
There are few therapeutic options to simultaneously tackle Staphylococcus aureus and Pseudomonas aeruginosa, two of the most relevant nosocomial and antibiotic-resistant pathogens responsible for implant, catheters and wound severe infections. The design and synthesis of polymers with inherent antimicrobial activity have gained increasing attention as a safe strategy to treat multidrug-resistant microbes. Here, we tested the activity of a new polymeric derivative with glyco-polypeptide architecture (PAA-VC) bearing L-arginine, vancomycin and colistin as side chains acting against multiple targets, which give rise to a broad spectrum antimicrobial activity favorably combining specific and nonspecific perturbation of the bacterial membrane...
December 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29244848/surface-modified-nanoparticles-as-anti-biofilm-filler-for-dental-polymers
#20
Nathan Zaltsman, Andrei C Ionescu, Ervin I Weiss, Eugenio Brambilla, Shaul Beyth, Nurit Beyth
The objective of the study was to synthesis silica nanoparticles modified with (i) a tertiary amine bearing two t-cinnamaldehyde substituents or (ii) dimethyl-octyl ammonium, alongside the well-studied quaternary ammonium polyethyleneimine nanoparticles. These were to be evaluated for their chemical and mechanical properties, as well for antibacterial and antibiofilm activity. Samples were incorporated in commercial dental resin material and the degree of monomer conversion, mechanical strength, and water contact angle were tested to characterize the effect of the nanoparticles on resin material...
2017: PloS One
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