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https://www.readbyqxmd.com/read/28147273/mir-182-regulates-slit2-mediated-axon-guidance-by-modulating-the-local-translation-of-a-specific-mrna
#1
Anaïs Bellon, Archana Iyer, Simone Bridi, Flora C Y Lee, Cesaré Ovando-Vázquez, Eloina Corradi, Sara Longhi, Michela Roccuzzo, Stephanie Strohbuecker, Sindhu Naik, Peter Sarkies, Eric Miska, Cei Abreu-Goodger, Christine E Holt, Marie-Laure Baudet
During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little is understood about how specific mRNAs are selected for translation. MicroRNAs (miRNAs) are critical translational regulators that act through a sequence-specific mechanism. Here, we investigate the local role of miRNAs in mRNA-specific translation during pathfinding of Xenopus laevis retinal ganglion cell (RGC) axons...
January 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/28125361/rna-mediated-communication-between-helminths-and-their-hosts-the-missing-links
#2
Julie Claycomb, Cei Abreu-Goodger, Amy H Buck
Small RNAs have been discovered in a wide variety of extracellular environments and are now thought to participate in communication between cells and even between different organisms and species. Helminths are parasitic worms that generally reside in extracellular niches in their hosts and can establish chronic infection through the release of immunomodulatory factors. Recent work has demonstrated that Extracellular RNA (exRNA) may be another class of immunomodulator secreted by helminths. Here we will detail what is known about small RNA pathways in helminth pathogens (focusing on nematodes) and mammalian hosts...
January 26, 2017: RNA Biology
https://www.readbyqxmd.com/read/28030890/assistance-to-states-for-the-education-of-children-with-disabilities-preschool-grants-for-children-with-disabilities-final-regulations
#3
(no author information available yet)
The Secretary amends the regulations under Part B of the Individuals with Disabilities Education Act (IDEA) governing the Assistance to States for the Education of Children with Disabilities program and the Preschool Grants for Children with Disabilities program. With the goal of promoting equity under IDEA, the regulations will establish a standard methodology States must use to determine whether significant disproportionality based on race and ethnicity is occurring in the State and in its local educational agencies (LEAs); clarify that States must address significant disproportionality in the incidence, duration, and type of disciplinary actions, including suspensions and expulsions, using the same statutory remedies required to address significant disproportionality in the identification and placement of children with disabilities; clarify requirements for the review and revision of policies, practices, and procedures when significant disproportionality is found; and require that LEAs identify and address the factors contributing to significant disproportionality as part of comprehensive coordinated early intervening services (comprehensive CEIS) and allow these services for children from age 3 through grade 12, with and without disabilities...
19, 2016: Federal Register
https://www.readbyqxmd.com/read/27999223/health-software-a-new-cei-guide-for-software-management-in-medical-environment
#4
Claudia Giacomozzi, Francesco Martelli
INTRODUCTION: The increasing spread of software components in the healthcare context renders explanatory guides relevant and mandatory to interpret laws and standards, and to support safe management of software products in healthcare. METHODOLOGY: In 2012 a working group has been settled for the above purposes at Italian Electrotechnical Committee (CEI), made of experts from Italian National Institute of Health (ISS), representatives of industry, and representatives of the healthcare organizations...
October 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27942722/a-period-of-controlled-elevation-of-iop-cei-produces-the-specific-gene-expression-responses-and-focal-injury-pattern-of-experimental-rat-glaucoma
#5
John C Morrison, William O Cepurna, Shandiz Tehrani, Tiffany E Choe, Hari Jayaram, Diana C Lozano, Brad Fortune, Elaine C Johnson
Purpose: We determine if several hours of controlled elevation of IOP (CEI) will produce the optic nerve head (ONH) gene expression changes and optic nerve (ON) damage pattern associated with early experimental glaucoma in rats. Methods: The anterior chambers of anesthetized rats were cannulated and connected to a reservoir to elevate IOP. Physiologic parameters were monitored. Following CEI at various recovery times, ON cross-sections were graded for axonal injury...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918289/a-bioreactor-with-an-electro-responsive-elastomeric-membrane-for-mimicking-intestinal-peristalsis
#6
Daniele Cei, Joana Costa, Giulia Gori, Gabriele Frediani, Claudio Domenici, Federico Carpi, Arti Ahluwalia
This study describes an actuated bioreactor which mimics the pulsatile contractile motion of the intestinal barrier using electro-responsive elastomers as smart materials that undergo deformation upon electrical stimulation. The device consists of an annular dielectric elastomer actuator working as a radial artificial muscle able to rhythmically contract and relax a central cell culture well. The bioreactor maintained up to 4 h of actuation at a frequency of 0.15 Hz and a strain of 8%-10%, to those of the cyclic contraction and relaxation of the small intestine...
December 5, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27909155/extrapolation-techniques-evaluating-24-hours-of-average-electromagnetic-field-emitted-by-radio-base-station-installations-spectrum-analyzer-measurements-of-lte-and-umts-signals
#7
Stefano Mossetti, Daniela de Bartolo, Ivan Veronese, Marie Claire Cantone, Cristina Cosenza, Elisa Nava
International and national organizations have formulated guidelines establishing limits for occupational and residential electromagnetic field (EMF) exposure at high-frequency fields. Italian legislation fixed 20 V/m as a limit for public protection from exposure to EMFs in the frequency range 0.1 MHz-3 GHz and 6 V/m as a reference level. Recently, the law was changed and the reference level must now be evaluated as the 24-hour average value, instead of the previous highest 6 minutes in a day. The law refers to a technical guide (CEI 211-7/E published in 2013) for the extrapolation techniques that public authorities have to use when assessing exposure for compliance with limits...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27906948/cervical-interlaminar-epidural-injections-at-high-doses-do-not-increase-optic-nerve-sheath-diameter-on-a-long-term-basis
#8
Hyunzu Kim, Joo Hyeon O, Sung-Jun Hong, Keun Man Shin, JungChan Park, Sang Soo Kang
BACKGROUND: Cervical epidural injection (CEI) is widely performed on patients with pain originating from the cervical spine. Studies have shown a good relationship between the optic nerve sheath diameter (ONSD) and the intracranial pressure (ICP). OBJECTIVE: The aim of this study was to evaluate the changes in the ONSD as a non-invasive surrogate marker of ICP after CEI. STUDY DESIGN: Prospective observational study. SETTING: Hospital and ambulatory pain clinic...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27884186/general-practitioners-in-german-metropolitan-areas-distribution-patterns-and-their-relationship-with-area-level-measures-of-the-socioeconomic-status
#9
Jan Bauer, Doerthe Brueggmann, Daniela Ohlendorf, David A Groneberg
BACKGROUND: Geographical variation of the general practitioner (GP) workforce is known between rural and urban areas. However, data about the variation between and within urban areas are lacking. METHOD: We analyzed distribution patterns of GP full time equivalents (FTE) in German cities with a population size of more than 500,000. We correlated their distribution with area measures of social deprivation in order to analyze preferences within neighborhood characteristics...
November 25, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27883307/informed-consent-in-the-medical-care-of-transgender-and-gender-nonconforming-patients
#10
Timothy Cavanaugh, Ruben Hopwood, Cei Lambert
Informed consent as a model of care has evolved as an alternative to the standard model of care recommended by the World Professional Association for Transgender Health's Standards of Care, version 7, which emphasizes the importance of mental health professionals' role in diagnosing gender dysphoria and in assessing the appropriateness and readiness for gender-affirming medical treatments. By contrast, the informed consent model for gender-affirming treatment seeks to acknowledge and better support the patient's right to, and capability for, personal autonomy in choosing care options without the required involvement of a mental health professional...
November 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27878663/prevention-and-treatment-of-venous-thromboembolism-in-patients-with-solid-brain-neoplasms-results-of-a-survey-among-italian-physicians
#11
Nicola Mumoli, Stefano Barco, Marco Cei, Matteo Giorgi-Pierfranceschi, Mauro Campanini, Andrea Fontanella, Walter Ageno, Francesco Dentali
The decision concerning the introduction of primary and secondary prophylaxis of venous thromboembolism (VTE) in patients with solid brain neoplasms and brain metastases is often challenging due to the concomitant increased risk of intracranial hemorrhage and to limited evidence from available literature. A standardized questionnaire composed of nine multiple-choice questions regarding primary VTE prevention in non-surgical patients during high-risk conditions and VTE secondary prevention in patients with a solid brain neoplasm or cerebral metastases was sent via electronic mail to all the members (n = 2420) of the Italian Federation of the Internal Medicine Hospital Executives' Associations (FADOI) in June 2015...
November 23, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27876851/the-genome-transcriptome-and-proteome-of-the-nematode-steinernema-carpocapsae-evolutionary-signatures-of-a-pathogenic-lifestyle
#12
Alejandra Rougon-Cardoso, Mitzi Flores-Ponce, Hilda Eréndira Ramos-Aboites, Christian Eduardo Martínez-Guerrero, You-Jin Hao, Luis Cunha, Jonathan Alejandro Rodríguez-Martínez, Cesaré Ovando-Vázquez, José Roberto Bermúdez-Barrientos, Cei Abreu-Goodger, Norberto Chavarría-Hernández, Nelson Simões, Rafael Montiel
The entomopathogenic nematode Steinernema carpocapsae has been widely used for the biological control of insect pests. It shares a symbiotic relationship with the bacterium Xenorhabdus nematophila, and is emerging as a genetic model to study symbiosis and pathogenesis. We obtained a high-quality draft of the nematode's genome comprising 84,613,633 bp in 347 scaffolds, with an N50 of 1.24 Mb. To improve annotation, we sequenced both short and long RNA and conducted shotgun proteomic analyses. S. carpocapsae shares orthologous genes with other parasitic nematodes that are absent in the free-living nematode C...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27828678/health-and-innovation-economic-dynamics-and-welfare-state-in-brazil
#13
Carlos Augusto Grabois Gadelha, Patrícia Seixas da Costa Braga
The effective enforcement of the access to healthcare as fundamental right requires an important theoretical and political effort at linking the often contradictory economic and social dimensions of development. This study suggests the need for a systemic view of policies related to the industrial base and innovation in health and the construction of the Brazilian Unified National Health System (SUS). The authors investigate the relations between health, innovation, and development, seeking to show and update the political, economic, and social determinants of the recent Brazilian experience with the Health Economic-Industrial Complex (HEIC)...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27828677/innovation-development-and-financing-of-institutions-of-higher-education-in-health
#14
Mario Roberto Dal Poz, Maria Helena Costa Couto, Thais de Andrade Vidaurre Franco
The article analyzes the configuration and trends in institutions of Higher Education and their relationship as components of the Health Economic-Industrial Complex (HEIC). The expansion of higher education is part of the transition from elite to mass systems, with tensions between quantitative and qualitative aspects. Such changes reflect different cultures and are related to international phenomena such as globalization, economic transformations, the development of new information and communication technologies, and the emergence of an international knowledge network...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27792312/impact-of-selected-lipf6-hydrolysis-products-on-the-high-voltage-stability-of-lithium-ion-battery-cells
#15
Ralf Wagner, Martin Korth, Benjamin Streipert, Johannes Kasnatscheew, Dennis R Gallus, Sebastian Brox, Marius Amereller, Isidora Cekic-Laskovic, Martin Winter
Diverse LiPF6 hydrolysis products evolve during lithium-ion battery cell operation at elevated operation temperatures and high operation voltages. However, their impact on the formation and stability of the electrode/electrolyte interfaces is not yet investigated and understood. In this work, literature-known hydrolysis products of LiPF6 dimethyl fluorophosphate (DMFP) and diethyl fluorophosphate (DEFP) were synthesized and characterized. The use of DMFP and DEFP as electrolyte additive in 1 M LiPF6 in EC:EMC (1:1, by wt) was investigated in LiNi1/3Mn1/3Co1/3O2/Li half cells...
November 16, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27750414/a-mechanistic-investigation-of-the-gold-iii-catalyzed-hydrofurylation-of-c-c-multiple-bonds
#16
Amin Hossein Bagi, Yousef Khaledi, Hossein Ghari, Sebastian Arndt, A Stephen K Hashmi, Brian F Yates, Alireza Ariafard
The gold-catalyzed direct functionalization of aromatic C-H bonds has attracted interest for constructing organic compounds which have application in pharmaceuticals, agrochemicals, and other important fields. In the literature, two major mechanisms have been proposed for these catalytic reactions: inner-sphere syn-addition and outer-sphere anti-addition (Friedel-Crafts-type mechanism). In this article, the AuCl3-catalyzed hydrofurylation of allenyl ketone, vinyl ketone, ketone, and alcohol substrates is investigated with the aid of density functional theory calculations, and it is found that the corresponding functionalizations are best rationalized in terms of a novel mechanism called "concerted electrophilic ipso-substitution" (CEIS) in which the gold(III)-furyl σ-bond produced by furan auration acts as a nucleophile and attacks the protonated substrate via an outer-sphere mechanism...
November 9, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27708535/r2-map-by-ideal-iq-for-acute-cerebral-infarction-compared-with-susceptibility-vessel-sign-on-t2-weighted-imaging
#17
Yuki Shinohara, Ayumi Kato, Eijiro Yamashita, Toshihide Ogawa
BACKGROUND: To evaluate the detectability of arterial acute thrombus on R2* map by iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) IQ compared with T2*-weighted imaging (T2*WI). METHODS: Twenty-six patients with acute cerebral infarction who underwent R2* map and T2*WI were reviewed. We performed visual assessment of each sequence regarding the visibility of susceptibility effect reflecting acute thrombus and quantitative evaluation of the thrombus on R2* map...
September 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/27615949/the-tadpole-of-odontophrynus-monachus-caramaschi-napoli-2012-amphibia-anura-odontophrynidae
#18
Rafael C Menegucci, Marcus Thadeu T Santos, Rafael F De Magalhães, Ibere F Machado, Paulo C A Garcia, Tiago L Pezzuti
The genus Odontophrynus Reinhardt & Lütken comprises 11 species distributed throughout South and East of South America (Frost 2016) clustered in three phenetic groups: O. americanus, O. cultripes, and O. occidentalis (Savage & Cei 1965; Cei 1987; Caramaschi & Napoli 2012). Only the O. occidentalis group is recovered as monophyletic in the most recent phylogenetic hypotheses (Pyron & Wiens 2011; Pyron 2014). In these analyses, the O. cultripes group is not recovered and the monophyly of O. americanus group was not tested, since only one species of the group was included (Pyron & Wiens 2011; Pyron 2014)...
September 7, 2016: Zootaxa
https://www.readbyqxmd.com/read/27591455/a-prospective-randomized-blinded-endpoint-controlled-study-continuous-epidural-infusion-versus-programmed-intermittent-epidural-bolus-in-labor-analgesia
#19
Joana Nunes, Sara Nunes, Mariano Veiga, Mara Cortez, Isabel Seifert
BACKGROUND: There is evidence that administration of a programmed intermittent epidural bolus (PIEB) compared to continuous epidural infusion (CEI) leads to greater analgesia efficacy and maternal satisfaction with decreased anesthetic interventions. METHODS: In this study, 166 women with viable pregnancies were included. After an epidural loading dose of 10mL with Ropivacaine 0.16% plus Sufentanil 10μg, parturient were randomly assigned to one of three regimens: A - Ropivacaine 0...
September 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27576259/polymeric-microporous-nanofilms-as-smart-platforms-for-in-vitro-assessment-of-nanoparticle-translocation-and-caco-2-cell-culture
#20
Leonardo Ricotti, Giulia Gori, Daniele Cei, Joana Costa, Giovanni Signore, Arti Ahluwalia
The study of nanomaterial translocation across epithelial barriers is often hindered by the low permeability of transwell membranes to nanoparticles. To address this issue ultra-thin poly(L-lactic acid) nanofilms with zero tortuosity micropores were developed for use in nanoparticle passage tests. In this study we demonstrate that microporous polymeric nanofilms allow a significantly higher passage of silver nanoparticles in comparison with commercial membranes normally used in transwell inserts. A reliable procedure for collecting free-standing nanofilms which enables their manipulation and use in lab-on-chip systems is described...
October 2016: IEEE Transactions on Nanobioscience
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