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https://www.readbyqxmd.com/read/28509761/dabigatran-in-nonvalvular-atrial-fibrillation-from-clinical-trials-to-real-life-experience
#1
Nicola Mumoli, Daniela Mastroiacovo, Eleonora Tamborini-Permunian, Josè Vitale, Matteo Giorgi-Pierfranceschi, Marco Cei, Francesco Dentali
: Atrial fibrillation is the most common arrhythmia in over-midlife patients. In addition to systolic heart failure, cerebral thromboembolism represents the most dramatic complication of this rhythm disorder, contributing to morbidity and mortality. Traditionally, anticoagulation has been considered the main strategy in preventing stroke and systemic embolism in atrial fibrillation patients and vitamin K-dependent antagonists have been widely used in clinical practice. Recently, the development of direct oral anticoagulants has certainly improved the management of this disease, providing, for the first time, the opportunity to go beyond vitamin K-dependent antagonists limits...
July 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28501410/effects-of-dietary-energy-allowance-and-decline-in-dry-matter-intake-during-the-dry-period-on-responses-to-glucose-and-insulin-in-transition-dairy-cows
#2
S Salin, A Vanhatalo, K Elo, J Taponen, R C Boston, T Kokkonen
We assessed whether high energy intake during the early dry period [144% of metabolizable energy (ME) requirements/d] followed by a gradual restriction of energy intake in the close-up dry period (119% of ME/d; HEI) impaired whole-body insulin sensitivity compared with a controlled energy intake (100% of ME/d; CEI) throughout the 6-wk dry period. Multiparous Ayrshire dairy cows (n = 16) were blocked by body weight, body condition score, and expected date of parturition and were used in a randomized complete block design until 10 d after parturition...
May 10, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28497948/in-situ-visualized-cathode-electrolyte-interphase-on-licoo2-in-high-voltage-cycling
#3
Wei Lu, Jiansheng Zhang, Jingjing Xu, Xiaodong Wu, Liwei Chen
Charging lithium ion battery cathode materials such as LiCoO2 to a higher voltage may simultaneously enhance the specific capacity and average operating voltage and thus improve the energy density. However, battery cycle life is compromised in high voltage cycling due to lattice instability and undesired oxidation of electrolyte. Cathode solid-electrolyte interphase (SEI), or cathode-electrolyte interphase (CEI), in-situ formed at the cathode-electrolyte interface under high voltage, is critically important in understanding the cathode degradation process and crucial in improving high voltage cycle stability...
May 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28493788/development-of-in-vitro-embryo-production-system-using-collagen-matrix-gel-attached-vascular-endothelial-growth-factor-derived-from-interleukin-1-beta-treated-porcine-endometrial-tissue
#4
Hye-In Han, Sang-Hee Lee, Choon-Keun Park
The aim of this study was to establish an embryo culture system using collagen gel attached with vascular endothelial growth factor (VEGF) derived from interleukin-1 beta (IL-1β)-treated endometrial tissues from pigs. Endometria were separated from the porcine uterus at the follicular phase of the estrous cycle and were cultured with IL-1β. The collagen gels co-incubated with IL-1β-treated endometria (C, without endometrial tissue; CE, with endometrial tissue; and CEI, IL-1β-treated endometrial tissue) were used for embryo culture...
May 11, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28451764/mdct-of-the-liver-in-obese-patients-evaluation-of-a-different-method-to-optimize-iodine-dose
#5
Marco Rengo, Davide Bellini, Rita Businaro, Damiano Caruso, Gabriella Azzara, Domenico De Santis, Simona Picchia, Tommaso Biondi, Marwen Eid, Dario Boschiero, Andrea Laghi
PURPOSE: To prospectively compare two different approaches for estimating the amount of intravenous contrast media (CM) needed for multiphasic MDCT of the liver in obese patients. MATERIALS AND METHODS: This single-center, HIPAA-compliant prospective study was approved by our Institutional Review Board. Ninety-six patients (55 men, 41 women), with a total of 42 hypovascular liver lesions, underwent MDCT of the liver. The amount of contrast medium injected was computed according to the patient's lean body weight which was estimated using either a bioimpedance device (Group A) or the James formula (Group B)...
April 27, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28451592/the-consortium-for-electrocardiographic-imaging
#6
Jaume Coll-Font, Jwala Dhamala, Danila Potyagaylo, Walther Hw Schulze, Jess D Tate, Maria S Guillem, Peter van Dam, Olaf Dossel, Dana H Brooks, Rob S Macleod
Electrocardiographic imaging (ECGI) has recently gained attention as a viable diagnostic tool for reconstructing cardiac electrical activity in normal hearts as well as in cardiac arrhythmias. However, progress has been limited by the lack of both standards and unbiased comparisons of approaches and techniques across the community, as well as the consequent difficulty of effective collaboration across research groups.. To address these limitations, we created the Consortium for Electrocardiographic Imaging (CEI), with the objective of facilitating collaboration across the research community in ECGI and creating standards for comparisons and reproducibility...
September 2016: Computing in Cardiology
https://www.readbyqxmd.com/read/28441088/video-enabled-cue-exposure-based-intervention-improves-postdischarge-drinking-outcomes-among-alcohol-dependent-men-a-prospective-study-at-a-government-addiction-treatment-setting-in-india
#7
Prasanthi Nattala, Pratima Murthy, Kit Sang Leung, Sreevani Rentala, Jayashree Ramakrishna
Returning to alcohol use following inpatient treatment occurs due to various real life cues/triggers. It is a challenge to demonstrate to patients how to deal with these triggers during inpatient treatment. Aims of the current study were (a) to evaluate the effectiveness of video-enabled cue-exposure-based intervention (VE-CEI) in influencing treatment outcomes in alcohol dependence, (b) to identify postdischarge predictors of intervention failure (returning to ≥50% of baseline alcohol consumption quantity/day)...
April 25, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28402376/effect-of-low-water-content-in-protic-ionic-liquid-on-ions-electrosorption-in-porous-carbon-application-to-electrochemical-capacitors
#8
B Gorska, L Timperman, M Anouti, F Béguin
The effect of low water content (<20, 150, 1000, 10 000 ppm) in triethylammonium bis[(trifluoromethyl)sulfonyl]imide - [(C2H5)3N(+)H][TFSI(-)] - protic ionic liquid (PIL) on the performance of activated carbon (AC) electrodes as well as AC/AC electrochemical capacitors (ECs) is reported. Under negative polarization, hydrogen electrosorption onto carbon is enhanced along with the increase of water content in PIL, whereas the resulting desorption peaks are shifted to lower potential values, evidencing lower sorption energy when hydrogen is stored from moisture containing PIL...
April 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28355389/leptodactylus-chaquensis-cei-1950-leptodactylidae-leptodactylinae-extension-of-the-distribution-in-state-of-rio-grande-do-sul-southern-brazil
#9
V H S Teixeira, F M Quintela, D Loebmann
No abstract text is available yet for this article.
March 16, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28352951/the-value-of-adding-diffusion-weighted-images-for-tumor-detection-and-preoperative-staging-in-renal-pelvic-carcinoma-for-the-reader-s-experience
#10
Rika Yoshida, Takeshi Yoshizako, Minako Maruyama, Hiroshi Mori, Noriyoshi Ishikawa, Yukihisa Tamaki, Hajime Kitagaki
PURPOSE: This retrospective study aimed to assess the value of adding diffusion-weighted magnetic resonance imaging (DWI) or gadolinium-enhanced fat-suppressed T1WI (CEI) to T2-weighted imaging (T2WI) for preoperative T categorization in renal pelvic carcinoma by the reader's experience using surgical specimens as the reference standard. METHODS: Two radiologists (Reader 1; 3 years, 2; 13 years) reviewed 49 cases with urothelial carcinoma who underwent magnetic resonance imaging examination before surgery, independently, using three image sets: T2WI alone, T2WI plus DWI, and T2WI plus CEI for tumor detection and T categorization...
March 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28347895/metabolomic-changes-in-rat-model-of-cauda-equina-injury
#11
Yang Liu, Rui Yang, Qingjie Kong, Yuan Wang, Bin Zhang, Jingchuan Sun, Yong Yang, Bing Zheng, Hongbin Yuan, Jiangang Shi
BACKGROUND: To demonstrate the differences of metabolomic changes in a rat model of cauda equina injury (CEI) and find potent metabolic biomarkers of CEI. MATERIAL AND METHODS: A total of 28 Sprague-Dawley (SD) rats were used in this study. After the rats were given anesthesia and fixed in a prone position, a piece of silicone block was placed into the epidural space below the lamina. Behavior tests including the Basso, Beattie, and Bresnahan (BBB) open field locomotor scale and an inclined plane test were conducted 1 day and 2 days after surgery...
March 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28266279/synthesis-characterization-and-cholinesterase-inhibition-studies-of-new-arylidene-aminothiazolylethanone-derivatives
#12
Jamshed Iqbal, Ghulam Shabir, Fayaz A Larik, Shafi Ullah Khan, Aamer Saeed, Muhammad S Shah, Pervaiz A Channar
BACKGROUND: Alzheimer's disease is caused by the destruction or loss of cholinergic cells that produce or use ACh in the brain, thereby reducing the availability of enzyme to other cells. The major treatment strategy for AD is to decrease the level of cholinesterase in the brain. OBJECTIVE: The aim of this study was to describe the effect of novel series of thiazole derivatives i.e. arylidene aminothiazolylethanones (3a-h) as cholinesterase inhibitors (CEIs). METHODS: A novel series of thiazole derivatives i...
March 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28265414/pesticide-metabolite-and-oxidative-stress-in-male-farmers-exposed-to-pesticide
#13
Kang Myoung Lee, Sang-Yoo Park, Kyungsuk Lee, Sung-Soo Oh, Sang Baek Ko
BACKGROUND: The objective of this study was to measure malondialdehyde (MDA) and isoprostane which has been used as an index of lipid injury, 8-hydroxy-2'-deoxyguanosine (8-OHdG), which has been used as an index of DNA damage, and dialkyl-phosphate (DAP), which has been used to quantify pesticide exposure, and to investigate the relationship between pesticide exposure and oxidative stress. METHODS: This study was a cross-sectional study that evaluated 84 male farmers exposure to pesticide...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28258541/effect-of-changes-in-the-nutritional-status-on-the-performances-of-growing-creole-kids-during-an-established-nematode-parasite-infection
#14
W Ceï, H Archimède, R Arquet, Y Félicité, D Feuillet, A Nepos, P Mulciba, T Etienne, G Alexandre, J C Bambou
In this study, we evaluated the effect of changes in the nutritional status on the performances of growing Creole kids during an established experimental gastrointestinal nematode (GIN) infection. Eighteen 6-month-old Creole kids were distributed in two main groups infected (I) and non-infected (NI) and were placed for a period of 4 weeks on each of three diets differing in their nutritional values: (1) fresh grass (FG, 6.7 MJ/kg dry matter (DM) and 7.9% crude protein (CP)) non-supplemented, (2) FG supplemented with a commercial concentrate (CC, 12...
March 3, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28243535/modeling-using-clinical-examination-indicators-predicts-interstitial-lung-disease-among-patients-with-rheumatoid-arthritis
#15
Yao Wang, Wuqi Song, Jing Wu, Zhangming Li, Fengyun Mu, Yang Li, He Huang, Wenliang Zhu, Fengmin Zhang
Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting in poor prognosis and increased lifetime risk. We investigated whether routine clinical examination indicators (CEIs) could be used to identify RA patients with high PF risk. A total of 533 patients with established RA were recruited in this study for model building and 32 CEIs were measured for each of them...
2017: PeerJ
https://www.readbyqxmd.com/read/28216536/the-fraction-of-exhaled-nitric-oxide-feno-and-forced-oscillation-technique-fot-can-predict-bronchial-hyperresponsiveness-against-acetylcholine-in-treated-asthmatics
#16
Masanori Fukuhara, Takahiro Tsuburai, Yuto Nakamura, Yasuhiro Tomita, Yuto Hamada, Kentaro Watai, Hiroaki Hayashi, Yousuke Kamide, Kiyoshi Sekiya, Chihiro Mitsui, Yuma Fukutomi, Akio Mori, Masami Taniguchi
BACKGROUND: The bronchial hyperresponsiveness (BHR) test is useful to diagnose or evaluate effect of therapy in asthmatics, but invasive. On the other hands, the fraction of exhaled nitric oxide (FENO) is a useful noninvasive marker of eosinophilic airway inflammation in asthmatics. And also, the forced oscillation technique (FOT) is a noninvasive method that is used to measure respiratory mechanics, including respiratory resistance and reactance at multiple frequencies. AIM: To evaluate the complementary roles of FENO and FOT to predict bronchial hyperresponsiveness in adult stable asthmatic patients taking inhaled corticosteroids...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28147273/mir-182-regulates-slit2-mediated-axon-guidance-by-modulating-the-local-translation-of-a-specific-mrna
#17
Anaïs Bellon, Archana Iyer, Simone Bridi, Flora C Y Lee, Cesaré Ovando-Vázquez, Eloina Corradi, Sara Longhi, Michela Roccuzzo, Stephanie Strohbuecker, Sindhu Naik, Peter Sarkies, Eric Miska, Cei Abreu-Goodger, Christine E Holt, Marie-Laure Baudet
During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little is understood about how specific mRNAs are selected for translation. MicroRNAs (miRNAs) are critical translational regulators that act through a sequence-specific mechanism. Here, we investigate the local role of miRNAs in mRNA-specific translation during pathfinding of Xenopus laevis retinal ganglion cell (RGC) axons...
January 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/28125361/rna-mediated-communication-between-helminths-and-their-hosts-the-missing-links
#18
Julie Claycomb, Cei Abreu-Goodger, Amy H Buck
Small RNAs have been discovered in a wide variety of extracellular environments and are now thought to participate in communication between cells and even between different organisms and species. Helminths are parasitic worms that generally reside in extracellular niches in their hosts and can establish chronic infection through the release of immunomodulatory factors. Recent work has demonstrated that Extracellular RNA (exRNA) may be another class of immunomodulator secreted by helminths. Here we will detail what is known about small RNA pathways in helminth pathogens (focusing on nematodes) and mammalian hosts...
April 3, 2017: RNA Biology
https://www.readbyqxmd.com/read/28030890/assistance-to-states-for-the-education-of-children-with-disabilities-preschool-grants-for-children-with-disabilities-final-regulations
#19
(no author information available yet)
The Secretary amends the regulations under Part B of the Individuals with Disabilities Education Act (IDEA) governing the Assistance to States for the Education of Children with Disabilities program and the Preschool Grants for Children with Disabilities program. With the goal of promoting equity under IDEA, the regulations will establish a standard methodology States must use to determine whether significant disproportionality based on race and ethnicity is occurring in the State and in its local educational agencies (LEAs); clarify that States must address significant disproportionality in the incidence, duration, and type of disciplinary actions, including suspensions and expulsions, using the same statutory remedies required to address significant disproportionality in the identification and placement of children with disabilities; clarify requirements for the review and revision of policies, practices, and procedures when significant disproportionality is found; and require that LEAs identify and address the factors contributing to significant disproportionality as part of comprehensive coordinated early intervening services (comprehensive CEIS) and allow these services for children from age 3 through grade 12, with and without disabilities...
December 19, 2016: Federal Register
https://www.readbyqxmd.com/read/27999223/health-software-a-new-cei-guide-for-software-management-in-medical-environment
#20
Claudia Giacomozzi, Francesco Martelli
INTRODUCTION: The increasing spread of software components in the healthcare context renders explanatory guides relevant and mandatory to interpret laws and standards, and to support safe management of software products in healthcare. METHODOLOGY: In 2012 a working group has been settled for the above purposes at Italian Electrotechnical Committee (CEI), made of experts from Italian National Institute of Health (ISS), representatives of industry, and representatives of the healthcare organizations...
October 2016: Annali Dell'Istituto Superiore di Sanità
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