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Amin Hossein Bagi, Yousef Khaledi, Hossein Ghari, Sebastian Arndt, A Stephen K Hashmi, Brian F Yates, Alireza Ariafard
The gold-catalyzed direct functionalization of aromatic C-H bonds has attracted interest for constructing organic compounds which have application in pharmaceuticals, agrochemicals, and other important fields. In the literature, two major mechanisms have been proposed for these catalytic reactions: inner-sphere syn-addition and outer-sphere anti-addition (Friedel-Crafts-type mechanism). In the current article, the AuCl3-catalyzed hydrofurylation of allenyl ketone, vinyl ketone, ketone and alcohol substrates is investigated with the aid of density functional theory calculations and it is found that the corresponding functionalizations are best rationalized in terms of a novel mechanism called "concerted electrophilic ipso-substitution" (CEIS) in which the gold(III)-furyl σ-bond produced by furan auration acts as a nucleophile and attacks the protonated substrate via an outer-sphere mechanism...
October 17, 2016: Journal of the American Chemical Society
Yuki Shinohara, Ayumi Kato, Eijiro Yamashita, Toshihide Ogawa
BACKGROUND: To evaluate the detectability of arterial acute thrombus on R2* map by iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) IQ compared with T2*-weighted imaging (T2*WI). METHODS: Twenty-six patients with acute cerebral infarction who underwent R2* map and T2*WI were reviewed. We performed visual assessment of each sequence regarding the visibility of susceptibility effect reflecting acute thrombus and quantitative evaluation of the thrombus on R2* map...
September 2016: Yonago Acta Medica
Rafael C Menegucci, Marcus Thadeu T Santos, Rafael F De Magalhães, Ibere F Machado, Paulo C A Garcia, Tiago L Pezzuti
The genus Odontophrynus Reinhardt & Lütken comprises 11 species distributed throughout South and East of South America (Frost 2016) clustered in three phenetic groups: O. americanus, O. cultripes, and O. occidentalis (Savage & Cei 1965; Cei 1987; Caramaschi & Napoli 2012). Only the O. occidentalis group is recovered as monophyletic in the most recent phylogenetic hypotheses (Pyron & Wiens 2011; Pyron 2014). In these analyses, the O. cultripes group is not recovered and the monophyly of O. americanus group was not tested, since only one species of the group was included (Pyron & Wiens 2011; Pyron 2014)...
2016: Zootaxa
Joana Nunes, Sara Nunes, Mariano Veiga, Mara Cortez, Isabel Seifert
BACKGROUND: There is evidence that administration of a programmed intermittent epidural bolus (PIEB) compared to continuous epidural infusion (CEI) leads to greater analgesia efficacy and maternal satisfaction with decreased anesthetic interventions. METHODS: In this study, 166 women with viable pregnancies were included. After an epidural loading dose of 10mL with Ropivacaine 0.16% plus Sufentanil 10μg, parturient were randomly assigned to one of three regimens: A - Ropivacaine 0...
September 2016: Brazilian Journal of Anesthesiology
Leonardo Ricotti, Giulia Gori, Daniele Cei, Joana Costa, Giovanni Signore, Arti Ahluwalia
The study of nanomaterial translocation across epithelial barriers is often hindered by the low permeability of transwell membranes to nanoparticles. To address this issue ultra-thin poly(L-lactic acid) nanofilms with zero tortuosity micropores were developed for use in nanoparticle passage tests. In this study we demonstrate that microporous polymeric nanofilms allow a significantly higher passage of silver nanoparticles in comparison with commercial membranes normally used in Transwell inserts. A robust procedure for collecting free-standing nanofilms which enables their manipulation and use in lab-on-chip systems is described...
August 25, 2016: IEEE Transactions on Nanobioscience
Lorenzo Ball, Giulia Pellerano, Laura Corsi, Nadia Giudici, Anna Pellegrino, Daniela Cannata, Gregorio Santori, Domenico Palombo, Paolo Pelosi, Angelo Gratarola
BACKGROUND: We compared a bundle of interventions including wound infiltration and continuous infusion with local anaesthetics plus a single morphine bolus (CWI-M) with continuous epidural infusion (CEI) as postoperative analgesia. METHODS: Fifty-one adults undergoing open abdominal aortic aneurysm repair were randomised in this non-inferiority open-label trial. In the CEI group, patients received thoracic epidural levobupivacaine 0.12% plus sufentanil 0.4 g·ml-1 infusion for 48h...
August 30, 2016: Minerva Anestesiologica
Hironao Okubo, Tsuneo Kitamura, Hitoshi Ando, Hiroo Fukada, Yuki Igusa, Shigehiro Kokubu, Akihisa Miyazaki, Akio Fujimura, Shuichiro Shiina, Sumio Watanabe
Simeprevir is a substrate for organic anion-transporting polypeptides (OATPs) that transport bilirubin. Hyperbilirubinemia is an adverse event reported during treatment of chronic hepatitis C patients with simeprevir plus pegylated interferon and ribavirin. Because gadoxetic acid is also a substrate of OATPs, pretreatment gadoxetic acid-enhanced magnetic resonance imaging (MRI) may predict hyperbilirubinemia during treatment. This prospective study therefore evaluated 11 consecutive patients with chronic hepatitis C who underwent gadoxetic acid-enhanced MRI prior to treatment with simeprevir plus pegylated interferon and ribavirin for 12 weeks, followed by pegylated interferon and ribavirin for an additional 12 weeks...
August 17, 2016: Journal of Clinical Pharmacology
Krishna Juluru, Andrew H Talal, Rhonda K Yantiss, Pascal Spincemaille, Elizabeth K Weidman, Ashley E Giambrone, Sadaf Jalili, Steven P Sourbron, Jonathan P Dyke
PURPOSE: To assess the diagnostic accuracy of intracellular uptake rates (Ki ), and other quantitative pharmacokinetic (PK) parameters, for hepatic fibrosis stage; to compare this accuracy with a previously published semiquantitative metric, contrast enhancement index (CEI); and to assess variability of these parameters between liver regions. MATERIALS AND METHODS: This was a case-control study design. Dynamic Gd-EOB-DTPA-enhanced 1.5T magnetic resonance imaging (MRI) was performed prospectively in 22 subjects with varying known stages of hepatic fibrosis...
August 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
Christophe Paris, Isabelle Thaon, Fabrice Hérin, Benedicte Clin, Aude Lacourt, Amandine Luc, Gaelle Coureau, Patrick Brochard, Soizick Chamming's, Antoine Gislard, Pilar Galan, Serge Hercberg, Pascal Wild, Jean-Claude Pairon, Pascal Andujar
BACKGROUND: The relationships between asbestos exposure and colorectal cancer remain controversial. OBJECTIVES: To examine the association between asbestos exposure and colorectal cancer incidence. METHODS: Volunteer retired workers previously exposed to asbestos were invited to participate in the French ARDCo screening program between 2003 and 2005. Additional data on risk factors for colorectal cancer were collected from the ARDCo-NUT subsample of 3,769 participants in 2011...
August 12, 2016: Environmental Health Perspectives
Alejandro Sanchez-Flores, Fernando Peñaloza, Javier Carpinteyro-Ponce, Nestor Nazario-Yepiz, Cei Abreu-Goodger, Carlos A Machado, Therese Ann Markow
We report genomes of two species of cactophilic Drosophila: Drosophila arizonae and D. navojoa These two are the closest relatives of D. mojavensis, forming the D. mojavensis cluster. D. mojavensis and D. arizonae diverged from D. navojoa ∼5.8 Mya, while the split between D. arizonae and D. mojavensis is more recent, at 1.5 Mya. Together the three genomes provide opportunities to examine genomic changes associated with speciation and host shifts in this ecologically defined group of flies. The three species are also separated by fixed inversion differences in three of their six chromosomes...
October 13, 2016: G3: Genes—Genomes—Genetics
Yunan Lin, Qiang Li, Jinlu Liu, Ruimin Yang, Jingchen Liu
BACKGROUND: This study aims to investigate differences between continuous epidural infusion (CEI) and programmed intermittent epidural bolus (IEB) analgesia for the Chinese parturients undergoing spontaneous delivery and to approach their safety to parturients and neonates. METHODS: Two hundred healthy American Society of Anesthesiologists class I or II, term (≥37 weeks' gestation), nulliparous women who requested analgesia for labor were recruited. Epidural analgesia was initiated with a solution of 0...
2016: Therapeutics and Clinical Risk Management
Brendan Carvalho, Ronald B George, Benjamin Cobb, Christine McKenzie, Edward T Riley
Programmed intermittent epidural bolus (PIEB) is an exciting new technology that has the potential to improve the maintenance of epidural labor analgesia. PIEB compared with a continuous epidural infusion (CEI) has the potential advantage of greater spread within the epidural space and therefore better sensory blockade. Studies have demonstrated a local anesthetic-sparing effect, fewer instrumental vaginal deliveries, less motor blockade, and improvements in maternal satisfaction with PIEB compared with CEI...
October 2016: Anesthesia and Analgesia
Joana Nunes, Sara Nunes, Mariano Veiga, Mara Cortez, Isabel Seifert
BACKGROUND: There is evidence that administration of a programmed intermittent epidural bolus (PIEB) compared to continuous epidural infusion (CEI) leads to greater analgesia efficacy and maternal satisfaction with decreased anesthetic interventions. METHODS: In this study, 166 women with viable pregnancies were included. After an epidural loading dose of 10mL with Ropivacaine 0.16% plus Sufentanil 10μg, parturient were randomly assigned to one of three regimens: A - Ropivacaine 0...
September 2016: Revista Brasileira de Anestesiologia
Yao-Min Liu, Bruno G Nicolau, Jennifer L Esbenshade, Andrew A Gewirth
The solid electrolyte interface (SEI) formed via electrolyte decomposition on the anode of lithium ion batteries is largely responsible for the stable cycling of conventional lithium ion batteries. Similarly, there is a lesser-known analogous layer on the cathode side of a lithium ion battery, termed the cathode electrolyte interface (CEI), whose composition and role are debated. To confirm the existence and composition of the CEI, desorption electrospray ionization mass spectrometry (DESI-MS) is applied to study common lithium ion battery cathodes...
July 19, 2016: Analytical Chemistry
Dongwen Wang, Amneris E Luque
The New York State HIV-HCV-STD Clinical Education Initiative (CEI) has developed a large repository of online resources and disseminated them to a wide range of healthcare providers. To evaluate the CEI online education program and in particular to compare the self-reported measures by clinicians from different disciplines, we analyzed the data from 1,558 course completions in a study period of three months. The results have shown that the overall evaluations by the clinicians were very positive. Meanwhile, there were significant differences across the clinical disciplines...
2016: Studies in Health Technology and Informatics
Martin Pitzer, Gregor Kastirke, Maksim Kunitski, Till Jahnke, Tobias Bauer, Christoph Goihl, Florian Trinter, Carl Schober, Kevin Henrichs, Jasper Becht, Stefan Zeller, Helena Gassert, Markus Waitz, Andreas Kuhlins, Hendrik Sann, Felix Sturm, Florian Wiegandt, Robert Wallauer, Lothar Ph H Schmidt, Allan S Johnson, Manuel Mazenauer, Benjamin Spenger, Sabrina Marquardt, Sebastian Marquardt, Horst Schmidt-Böcking, Jürgen Stohner, Reinhard Dörner, Markus Schöffler, Robert Berger
The absolute configuration of individual small molecules in the gas phase can be determined directly by light-induced Coulomb explosion imaging (CEI). Herein, this approach is demonstrated for ionization with a single X-ray photon from a synchrotron light source, leading to enhanced efficiency and faster fragmentation as compared to previous experiments with a femtosecond laser. In addition, it is shown that even incomplete fragmentation pathways of individual molecules from a racemic CHBrClF sample can give access to the absolute configuration in CEI...
August 18, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Márton Király, Borbála Dalmadiné Kiss, Károly Vékey, István Antal, Krisztina Ludányi
Mass spectrometry is a highly sensitive high-throughput instrumental analytical technique. It is used to determine the molecular mass, but also gives information on molecular structure amd is used for quantitation as well. Although it was developed over 100 years ago, it continues to evolve, both with respect to figures of merit (like sensitivity) and with respect to applications in various novel fields of science and technology. Mass spectrometry is capable of studying macromolecules (like proteins and protein complexes), and has very high sensitivity, now compounds at the atto- or zeptomol level can also be studied...
2016: Acta Pharmaceutica Hungarica
Zsolt Czimmerer, Tamas Varga, Mate Kiss, Cesaré Ovando Vázquez, Quang Minh Doan-Xuan, Dominik Rückerl, Sudhir Gopal Tattikota, Xin Yan, Zsuzsanna S Nagy, Bence Daniel, Szilard Poliska, Attila Horvath, Gergely Nagy, Eva Varallyay, Matthew N Poy, Judith E Allen, Zsolt Bacso, Cei Abreu-Goodger, Laszlo Nagy
BACKGROUND: IL-4-driven alternative macrophage activation and proliferation are characteristic features of both antihelminthic immune responses and wound healing in contrast to classical macrophage activation, which primarily occurs during inflammatory responses. The signaling pathways defining the genome-wide microRNA expression profile as well as the cellular functions controlled by microRNAs during alternative macrophage activation are largely unknown. Hence, in the current work we examined the regulation and function of IL-4-regulated microRNAs in human and mouse alternative macrophage activation...
2016: Genome Medicine
Ya'nan Guo, Min Dong, Zhen Yang, Xiaoli Gao, Keju Wang, Chongfan Luo, Yide Ma, Jiuwen Zhang
BACKGROUND AND OBJECTIVES: Mammography analysis is an effective technology for early detection of breast cancer. Micro-calcification clusters (MCs) are a vital indicator of breast cancer, so detection of MCs plays an important role in computer aided detection (CAD) system, this paper proposes a new hybrid method to improve MCs detection rate in mammograms. METHODS: The proposed method comprises three main steps: firstly, remove label and pectoral muscle adopting the largest connected region marking and region growing method, and enhance MCs using the combination of double top-hat transform and grayscale-adjustment function; secondly, remove noise and other interference information, and retain the significant information by modifying the contourlet coefficients using nonlinear function; thirdly, we use the non-linking simplified pulse-coupled neural network to detect MCs...
July 2016: Computer Methods and Programs in Biomedicine
Sunyoung Lee, Dongil Choi, Woo Kyoung Jeong
PURPOSE: To evaluate the usefulness of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging in assessing the severity of cirrhosis and liver function. MATERIALS AND METHODS: This retrospective study included 120 patients who underwent Gd-EOB-DTPA-enhanced 3 Tesla (T) MR imaging (normal liver, n = 30; Child-Pugh class A, n = 30; B, n = 30; and C, n = 30). Groups were matched for underlying disease, age (±5 years), gender, and creatinine (±0...
May 19, 2016: Journal of Magnetic Resonance Imaging: JMRI
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