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Gyn onc

Kelly Shum, Amber Solivan, Parham Parto, Nichole Polin, Eiman Jahangir
BACKGROUND: Because of the improvements in survival rates, patients with breast cancer are now more likely to die from cardiovascular disease than from cancer. Thus, providing appropriate preventive cardiovascular care to patients with cancer is of the utmost importance. METHODS: We retrospectively compared the cardiovascular risk and management of 146 women treated at the Cardio-Oncology (Cardio-Onc) and the Obstetrics and Gynecology (Ob-Gyn) clinics. We calculated cardiovascular risk using the American College of Cardiology (ACC)/American Heart Association (AHA) atherosclerotic cardiovascular disease (ASCVD) risk calculator and the Framingham Risk Score Calculator...
2016: Ochsner Journal
Sara Farag, Jessica Fields, Elena Pereira, Kathy Chyjek, Katherine T Chen
BACKGROUND: Currently, there are thousands of medical applications (apps) on the market potentially leading to app overload. Finding useful and accurate apps may be time-consuming and frustrating to gynecologic oncologists. INTRODUCTION: The objective of this study is to identify and rate gynecologic oncology (gyn-onc) apps using the APPLICATIONS scoring system. MATERIALS AND METHODS: A list of nonconsumer gyn-onc apps was identified from the Apple iTunes and Google Play Stores...
May 17, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Cristiano Rossitto, Salvatore Gueli Alletti, Barbara Costantini, Francesco Fanfani, Giovanni Scambia
STUDY OBJECTIVE: To highlight the first case of laparoscopic hysterectomy performed with percutaneous instruments (The Percuvance System, Teleflex Incorporated, Wayne, PA). DESIGN: The basis of the system is a <3-mm diameter shaft that, when connected to an introducer tool tip, can be inserted percutaneously through the skin. The introducer tool tip can then be exchanged outside the body for a wide variety of 5-mm interchangeable surgical tool tips. The shaft is sufficiently strong to hold structures, and surgeons can use its interchangeable tool tips to grasp, cut, and manipulate tissue...
January 2016: Journal of Minimally Invasive Gynecology
Chel Hun Choi, Joon-Yong Chung, Hanbyoul Cho, Haruhisa Kitano, Eileen Chang, Kris Ylaya, Eun Joo Chung, Jae-Hoon Kim, Stephen M Hewitt
OBJECTIVES: Cervical cancer is one of the most common gynecological malignancies worldwide, and its association with the AMP-activated protein kinase (AMPK) is still unknown. We aimed to investigate the clinical correlation between AMPK expression and cervical cancer. METHODS: The expression of AMPKα1, AMPKα2 and phosphorylated AMPKα (p-AMPKα) was determined immunohistochemically in 524 formalin-fixed, paraffin-embedded malignant and premalignant cervical tissues...
2015: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Nicolas Chevalier, Françoise Paris, Sylvie Fontana, Jérôme Delotte, Laura Gaspari, Patricia Ferrari, Charles Sultan, Patrick Fénichel
BACKGROUND: McCune-Albright syndrome (MAS), due to a somatic mutation of the GNAS1 gene, begins usually in girls with peripheral precocious puberty. Ovarian autonomy may persist in adulthood with acyclic hyperestrogenemia, infertility, and a potential risk of estrogen-dependent cancer. CASE: A 22-year-old woman, with MAS, was referred for infertility with left macropolycystic ovary, hyperestrogenemia, and chronic anovulation unsuccessfully treated by controlled hyperstimulation...
December 2015: Journal of Pediatric and Adolescent Gynecology
Christine Cohidon, Jacques Cornuz, Nicolas Senn
BACKGROUND: According to the Organization for Economic Cooperation and Development, the Swiss healthcare system is one of the most effective in the world. Yet, as other occidental countries, it has to face the increase of chronic diseases frequency and its resulting cost, particularly for primary care (PC). However very few consistent data are available to describe PC features and its evolution over time. The aim of this study is to describe the evolution of the Swiss PC physicians' (PCPs) profile and activities between 1993 and 2012...
2015: BMC Family Practice
Christina Nagel, Natascha Ille, Jörg Aurich, Christine Aurich
Transrectal palpation and ultrasonography of the genital tract in mares are first-day skills for equine veterinarians. In this study, the learning outcome in equine gynecology after four times training on horses (group H4, n = 8), training on horses once (group H1, n = 9), and four times simulator-based training (group Sim, n = 8) was assessed in third-year veterinary students with two tests in live mares 14 days apart. The students of group H4 always scored better for transrectal palpation than students of group Sim and H1 (P < 0...
October 15, 2015: Theriogenology
M Untch, N Harbeck, J Huober, G von Minckwitz, B Gerber, H-H Kreipe, C Liedtke, N Marschner, V Möbus, H Scheithauer, A Schneeweiss, C Thomssen, C Jackisch, M W Beckmann, J-U Blohmer, S-D Costa, T Decker, I Diel, P A Fasching, T Fehm, W Janni, H-J Lück, N Maass, A Scharl, S Loibl
For the first time, this year's St. Gallen International Consensus Conference on the treatment of patients with primary breast cancer, which takes place every two years, was held not in St. Gallen (Switzerland) but - for logistical reasons - in Vienna (Austria) under its usual name. The 2015 St. Gallen International Consensus Conference was the 14th of its kind. As the international panel of the St. Gallen conference consists of experts from different countries, the consensus mirrors an international cross-section of opinions...
June 2015: Geburtshilfe und Frauenheilkunde
M Zarepisheh, Y Ye, L Xing
PURPOSE: To propose a new parallel-friendly optimization algorithm, based on alternating direction method of multipliers (ADMM), for solving optimization problems emerging in treatment planning and imaging METHODS: ADMM, emerging as a powerful tool for distributed optimization, is employed here for IMRT treatment planning. We modify the existing ADMM by integrating that with two optimization techniques known as Barzilai-Borwein gradient method and line search. We apply original and integrated ADMM, with various penalty parameter values, on three IMRT treatment planning cases and we compare their performance...
June 2015: Medical Physics
Mohamed Rezk, Ragab Dawood, Mohamed Abo-Elnasr, Alaa Al Halaby, Hala Marawan
OBJECTIVE: This study was conducted to evaluate the efficacy and safety of lactoferrin in comparison to ferrous sulphate for the treatment of iron deficiency anemia (IDA) during pregnancy. MATERIALS AND METHODS: This prospective, randomized, parallel-group, single-center study was conducted in the Department of Obstetrics and Gynecology at Menoufia University Hospital, Egypt and included a total of 200 pregnant women in the second trimester with IDA who were enrolled and randomly assigned either to receive 150 mg of dried ferrous sulphate capsules or lactoferrin 250 mg capsules once daily for eight consecutive weeks...
2016: Journal of Maternal-fetal & Neonatal Medicine
Louise Wilkins-Haug, Ann Celi, Ann Thomas, Joseph Frolkis, Ellen W Seely
OBJECTIVE: To assess health care providers' knowledge regarding pregnancy outcome as a risk factor for cardiovascular disease and evaluate the variables associated with their responses to questions about routine surveillance for cardiovascular disease. METHODS: A voluntary, anonymous survey of internal medicine and obstetric and gynecologic health care providers at an academic institution. Responses to a case-based and direct inquiry questionnaire were evaluated...
June 2015: Obstetrics and Gynecology
Fernando Sansone Rodrigues, Sérgio Peixoto, Fernando Adami, Beatriz da Costa Aguiar Alves, Flávia de Sousa Gehrke, Ligia Ajaime Azzalis, Virginia Berlanga de Campos Junqueira, Fernando Luiz Affonso Fonseca
OBJECTIVES: Treatment for lower genital tract infections is the major demand for gynecological services in public and private health centers in Brazil. The aims of this study were to evaluate the diagnostic resources proposed by Amsel, comparing them with the microflora evaluation by the Nugent score and thus propose a new cutoff point in this rating score, showing the complementarity of both diagnostic criteria. METHODS: A total of 136 female patients aged between 18 and 69years were evaluated and had their vaginal discharge samples collected...
August 2015: Journal of Microbiological Methods
(no author information available yet)
Perinatal depression, which includes major and minor depressive episodes that occur during pregnancy or in the first 12 months after delivery, is one of the most common medical complications during pregnancy and the postpartum period, affecting one in seven women. It is important to identify pregnant and postpartum women with depression because untreated perinatal depression and other mood disorders can have devastating effects on women, infants, and families. Several screening instruments have been validated for use during pregnancy and the postpartum period...
May 2015: Obstetrics and Gynecology
Julian Marschalek, Samir Helmy, Alice Schmidt, Stephan Polterauer, Martha Sobulska, Georg P Gyoeri, Christoph Grimm
OBJECTIVE: Renal transplant patients are at increased risk for human papillomavirus-related malignancies of the lower genital tract. Our aim was to describe the incidence of genital dysplasia, assess the most common cervical cancer screening intervals and identify independent risk factors for the development of genital dysplasia in renal transplant patients. DESIGN: Retrospective, non-interventional study from two centers. SETTING: Post-transplant nephrologic follow-up visit at the Medical University of Vienna and a Viennese teaching hospital...
August 2015: Acta Obstetricia et Gynecologica Scandinavica
Vicky Makker, Virginia L Filiaci, Lee-May Chen, Christopher J Darus, James E Kendrick, Gregory Sutton, Katherine Moxley, Carol Aghajanian
OBJECTIVE: This two-stage phase II study assessed activity of single agent dalantercept in patients with recurrent/persistent endometrial carcinoma (EMC). METHODS: Eligible patients had persistent/recurrent EMC after 1-2 prior cytotoxic regimens, measurable disease (RECIST 1.1), and GOG performance≤2. Dalantercept 1.2mg/kg subcutaneous was administered once every 3weeks until disease progression (PD)/development of prohibitory toxicity. Primary objectives were to estimate the proportion of patients with persistent/recurrent EMC, who survive progression-free without receiving non-protocol therapy (TPFS) for at least 6months and to estimate the proportion having objective tumor response...
July 2015: Gynecologic Oncology
Gita Suneja, Monica Bacon, William Small, Sang Y Ryu, Henry C Kitchener, David K Gaffney
INTRODUCTION: The burden of cervical cancer is large and growing in developing countries, due in large part to limited access to screening services and lack of human papillomavirus (HPV) vaccination. In spite of modern advances in diagnostic and therapeutic modalities, outcomes from cervical cancer have not markedly improved in recent years. Novel clinical trials are urgently needed to improve outcomes from cervical cancer worldwide. METHODS: The Cervix Cancer Research Network (CCRN), a subsidiary of the Gynecologic Cancer InterGroup, is a multi-national, multi-institutional consortium of physicians and scientists focused on improving cervical cancer outcomes worldwide by making cancer clinical trials available in low-, middle-, and high-income countries...
2015: Frontiers in Oncology
A Martan, J Mašata, K Švabík, R El-Haddad, P Hubka, J Krhut
OBJECTIVE: The objective of this study was to evaluate the cure effect of a transurethral injection of Bulkamid® for recurrent female stress and mixed urinary incontinence in women who had undergone failed tape surgery. Our hypothesis was that cure effect of Bulkamid® is positive in patients when previous tape anti-incontinence surgery has been unsuccessful. DESIGN: Retrospective clinical study. SETTINGS: Department of Obstetrics and Gynecology, 1st Medical Faculty, Charles University and General Faculty Hospital in Prague...
January 2015: Ceská Gynekologie
Valerio Gallotta, Camilla Nero, Vito Chiantera, Giovanni Scambia
STUDY OBJECTIVE: To show the feasibility of performing aortic lymphadenectomy with 3-mm instruments in gynecologic malignancies. PATIENT: A 43-year-old, multiparous patient with serous ovarian cancer grading 2, Fédération Internationale de Gynécologie et d'Obstétrique stage IC (intraoperative spillage). INTERVENTION: The patient was accidentally diagnosed with ovarian cancer after a right adnexectomy performed for an ovarian cyst. Once referred to our center, a delayed surgical staging was planned including total hysterectomy, left adnexectomy, aortic and pelvic lymphadenectomy, peritoneal biopsies, and total omentectomy...
May 2015: Journal of Minimally Invasive Gynecology
Y G Lin, J Shen, E Yoo, R Liu, H-Y Yen, A Mehta, A Rajaei, W Yang, P Mhawech-Fauceglia, F J DeMayo, J Lydon, P Gill, A S Lee
Rates of the most common gynecologic cancer, endometrioid adenocarcinoma (EAC), continue to rise, mirroring the global epidemic of obesity, a well-known EAC risk factor. Thus, identifying novel molecular targets to prevent and/or mitigate EAC is imperative. The prevalent Type 1 EAC commonly harbors loss of the tumor suppressor, Pten, leading to AKT activation. The major endoplasmic reticulum (ER) chaperone, GRP78, is a potent pro-survival protein to maintain ER homeostasis, and as a cell surface protein, is known to regulate the phosphatidylinositol 3-kinase (PI3K)/AKT pathway...
October 2015: Oncogene
Gunter De Win, Wouter Everaerts, Dirk De Ridder, Griet Peeraer
BACKGROUND: The purpose of this study was to investigate the exposure of Belgian residents in urology, general surgery, and gynecology to laparoscopic surgery and to training of laparoscopic skills in dedicated training facilities. METHODS: Three similar specialty-specific questionnaires were used to interrogate trainees in urology, general surgery, and gynecology about their exposure to laparoscopic procedures, their acquired laparoscopic experience, training patterns, training facilities, and motivation...
2015: Advances in Medical Education and Practice
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