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Heart failure normal ejection fraction

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https://www.readbyqxmd.com/read/29664200/prevalence-and-determinants-of-left-ventricular-diastolic-dysfunction-in-obese-subjects-and-the-role-of-left-ventricular-global-longitudinal-strain-and-mass-normalized-to-height
#1
Frank Lloyd Dini, Iacopo Fabiani, Mario Miccoli, Gian Giacomo Galeotti, Nicola Riccardo Pugliese, Andreina D'Agostino, Alessandra Scartabelli, Lorenzo Conte, Guido Salvetti, Ferruccio Santini, Roberto Pedrinelli
BACKGROUND: Left ventricular (LV) diastolic dysfunction (DD) is a frequent finding in obesity and may predispose to the development of heart failure (HF). However, no data are available on the prevalence of DD after the introduction of the 2016 Recommendations of the American Society of Echocardiography and the European Association of Cardiovascular Imaging. METHODS AND RESULTS: To assess the impact of the new Recommendations on the prevalence of DD and on their clinical and echocardiographic correlates in obesity, a prospective study was performed in 588 subjects with an ejection fraction (EF) ≥50% and no history of HF either obese (n = 402; mean age: 47 ± 12 years; women 71%; body mass index [BMI]: 44 ± 8 kg/m2 ), overweight (n = 86; BMI: 28 ± 1 kg/m2 ), or with a normal weight (n = 100; BMI: 22 ± 2 kg/m2 )...
April 17, 2018: Echocardiography
https://www.readbyqxmd.com/read/29661150/a-moderate-500-m-treadmill-walk-for-estimating-peak-oxygen-uptake-in-men-with-nyha-class-i-ii-heart-failure-and-reduced-left-ventricular-ejection-fraction
#2
Gianni Mazzoni, Biagio Sassone, Giovanni Pasanisi, Jonathan Myers, Simona Mandini, Stefano Volpato, Francesco Conconi, Giorgio Chiaranda, Giovanni Grazzi
BACKGROUND: Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus, several submaximal walking protocols have been developed and currently used to estimate peak oxygen consumption (VO2 peak) in CHF patients. However, these tests have to be performed at close to maximum exercise intensity...
April 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29652272/comparison-of-immediate-extubation-versus-ultrafast-tracking-strategy-in-the-management-of-off-pump-coronary-artery-bypass-surgery
#3
Amarja Sachin Nagre, Nagesh P Jambures
Introduction: Ultrafast tracking of anesthesia (UFTA) is practiced routinely, whereas immediate on-table extubation after off-pump coronary artery bypass (OPCAB) grafting surgery has many concerns. The purpose of our study was to evaluate the safety and feasibility of immediate extubation (IE) versus UFTA. Methods: Sixty patients were enrolled who underwent OPCAB surgery. The two groups IE and UFTA had thirty patients each. Inclusion criteria were patients for OPCAB surgery including left main stenosis...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29643065/pulmonary-effective-arterial-elastance-as-a-measure-of-right-ventricular-afterload-and-its-prognostic-value-in-pulmonary-hypertension-due-to-left-heart-disease
#4
Emmanouil Tampakakis, Sanjiv J Shah, Barry A Borlaug, Peter J Leary, Harnish H Patel, Wayne L Miller, Benjamin W Kelemen, Brian A Houston, Todd M Kolb, Rachel Damico, Stephen C Mathai, Edward K Kasper, Paul M Hassoun, David A Kass, Ryan J Tedford
BACKGROUND: Patients with combined post- and precapillary pulmonary hypertension due to left heart disease have a worse prognosis compared with isolated postcapillary. However, it remains unclear whether increased mortality in combined post- and precapillary pulmonary hypertension is simply a result of higher total right ventricular load. Pulmonary effective arterial elastance (Ea) is a measure of total right ventricular afterload, reflecting both resistive and pulsatile components. We aimed to test whether pulmonary Ea discriminates survivors from nonsurvivors in patients with pulmonary hypertension due to left heart disease and if it does so better than other hemodynamic parameters associated with combined post- and precapillary pulmonary hypertension...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29628278/left-atrial-dilatation-a-target-organ-damage-in-young-to-middle-age-hypertensive-patients-the-campania-salute-network
#5
Costantino Mancusi, Grazia Canciello, Raffaele Izzo, Silvia Damiano, Maria Gabriella Grimaldi, Nicola de Luca, Giovanni de Simone, Bruno Trimarco, Maria-Angela Losi
BACKGROUND: Left atrial (LA) volume is a predictor of outcome in hypertension. It is unclear whether or not this effect depends on coexisting target organ damage (TOD). PURPOSE: To investigate whether LA volume predicts outcome independently of TOD [left ventricular (LV) hypertrophy (LVH) and/or carotid plaque] in a registry of hypertensive treated patients. METHODS: From the Campania Salute Network registry, we selected 5844 young adult hypertensive patients <65 years old (mean age 50 ± 9 years, 41% women, 8% diabetic) without prevalent CV or valvular heart disease more than mild, with normal LV ejection fraction, stage III or less CKD and available follow-up...
March 27, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29627106/clinical-features-associated-with-nascent-left-ventricular-diastolic-dysfunction-in-a-population-aged-40-to-55-years
#6
Jonathan D Mosley, Rebecca T Levinson, Evan L Brittain, Deepak K Gupta, Eric Farber-Eger, Christian M Shaffer, Josh C Denny, Dan M Roden, Quinn S Wells
Diastolic dysfunction (DD), an abnormality in cardiac left ventricular (LV) chamber compliance, is associated with increased morbidity and mortality. Although DD has been extensively studied in older populations, co-morbidity patterns are less well characterized in middle-aged subjects. We screened 156,434 subjects with transthoracic echocardiogram reports available through Vanderbilt's electronic heath record and identified 6,612 subjects 40 to 55 years old with an LV ejection fraction ≥50% and diastolic function staging...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29623382/-the-heart-catheter-table-is-not-the-operating-table-intraindividual-comparison-of-pulmonary-artery-pressures
#7
M U Ziegler, H Reinelt
BACKGROUND: Patients undergoing cardiac surgery need extensive and invasive monitoring, which needs to be individually adapted for each patient and requires a diligent risk-benefit analysis. The use of a pulmonary artery catheter (PAC) seems to be justifiable in certain cases; therefore, the preoperative diagnosis of pulmonary hypertension represents an indication for perioperative monitoring with PAC in the S3 guidelines of the German Society for Anesthesiology and Intensive Care Medicine (DGAI)...
April 5, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29617005/high-right-ventricular-stroke-work-index-is-associated-with-worse-kidney-function-in-patients-with-heart-failure-with-preserved-ejection-fraction
#8
Napatt Kanjanahattakij, Natee Sirinvaravong, Francisco Aguilar, Akanksha Agrawal, Parasuram Krishnamoorthy, Shuchita Gupta
BACKGROUND: In patients with heart failure with preserved ejection fraction (HFpEF), worse kidney function is associated with worse overall cardiac mechanics. Right ventricular stroke work index (RVSWI) is a parameter of right ventricular function. The aim of our study was to determine the relationship between RVSWI and glomerular filtration rate (GFR) in patients with HFpEF. METHOD: This was a single-center cross-sectional study. HFpEF is defined as patients with documented heart failure with ejection fraction > 50% and pulmonary wedge pressure > 15 mm Hg from right heart catheterization...
February 28, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29609877/impact-of-catheter-ablation-of-atrial-fibrillation-on-long-term-clinical-outcomes-in-patients-with-heart-failure
#9
Sadamitsu Ichijo, Shinsuke Miyazaki, Shigeki Kusa, Hiroaki Nakamura, Hitoshi Hachiya, Takatsugu Kajiyama, Yoshito Iesaka
BACKGROUND: Heart failure (HF) promotes atrial fibrillation (AF) and AF worsens HF. This study aimed to investigate the long-term clinical outcomes after AF ablation in patients with HF. METHODS AND RESULTS: A total of 106 consecutive HF patients, including 51 (48.1%) with a reduced left ventricular ejection fraction (LVEF) (HFrEF) and 55 (51.9%) with a preserved LVEF (HFpEF), underwent AF ablation. All patients underwent successful pulmonary vein antrum isolation, and substrate modification was added in 38 (35...
March 30, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29600790/biatrial-electrical-and-structural-atrial-changes-in-heart-failure-electroanatomic-mapping-in-persistent-atrial-fibrillation-in-humans
#10
Sandeep Prabhu, Aleksandr Voskoboinik, Alex J A McLellan, Kah Y Peck, Bhupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Liang-Han Ling, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
OBJECTIVES: This study sought to characterize the biatrial substrate in heart failure (HF) and persistent atrial fibrillation (PeAF). BACKGROUND: Atrial fibrillation (AF) and HF frequently coexist; however, the contribution of HF to the biatrial substrate in PeAF is unclear. METHODS: Consecutive patients with PeAF and normal left ventricular (NLV) systolic function (left ventricular ejection fraction [LVEF] >55%) or idiopathic cardiomyopathy (LVEF ≤45%) undergoing AF ablation were enrolled...
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29580694/mean-right-atrial-pressure-for-estimation-of-left-ventricular-filling-pressure-in-patients-with-normal-left-ventricular-ejection-fraction-invasive-and-noninvasive-validation
#11
Sherif F Nagueh, Otto A Smiseth, Hisham Dokainish, Oyvind S Andersen, Muaz M Abudiab, Robert C Schutt, Arnav Kumar, Einar Gude, Kimi Sato, Serge C Harb, Allan L Klein
BACKGROUND: There is a paucity of data on the utility of right atrial pressure (RAP) for estimating pulmonary capillary wedge pressure (PCWP) in patients with normal ejection fraction (EF), including patients with heart failure with preserved EF. METHODS: Mean RAP was compared with PCWP in 129 patients (mean age, 61 ± 11 years; 45% men) with exertional dyspnea enrolled in a multicenter study. Measurements included left ventricular volumes, EF, and mitral inflow velocities...
March 23, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29573742/systemic-inflammation-in-dogs-with-advanced-stage-heart-failure
#12
Aleksandra Domanjko Petrič, Tajda Lukman, Barbara Verk, Alenka Nemec Svete
BACKGROUND: Although human studies have shown that inflammation plays a role in the development of congestive heart failure, scarce information exists on white blood cell count (WBC) and differential cell counts in various stages of heart failure in man and dogs. A few studies demonstrated increased concentrations of C-reactive protein (CRP), a major acute-phase protein, in cardiac diseases in dogs. Our research aimed to investigate whether CRP concentration, WBC and neutrophil count (NEUT), as markers of systemic inflammation, are elevated in canine cardiovascular patients...
March 24, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29572321/ablation-outcomes-and-predictors-of-mortality-following-catheter-ablation-for-ventricular-tachycardia-data-from-the-german-multicenter-ablation-registry
#13
Roland Richard Tilz, Tina Lin, Lars Eckardt, Thomas Deneke, Dietrich Andresen, Heinrich Wieneke, Johannes Brachmann, Stefan Kääb, K R Julian Chun, Paula Münkler, Thorsten Lewalter, Matthias Hochadel, Jochen Senges, Karl-Heinz Kuck
BACKGROUND: Ventricular tachycardia (VT) causes significant morbidity and mortality. Implantable cardioverter-defibrillator shocks terminate VT but confer a significant morbidity and mortality risk. Therefore, VT ablation is increasingly common. Patients with structural heart disease (SHD) and patients with structurally normal hearts as well as the subgroup with and without ischemic heart disease were assessed for predictors of mortality and nonfatal VT recurrence. We present the first multicenter, prospective German VT registry...
March 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29569273/the-predictive-value-of-global-longitudinal-strain-on-clinical-outcome-in-patients-with-st-segment-elevation-myocardial-infarction-and-preserved-systolic-function
#14
Ahmed Bendary, Wael Tawfeek, Mohammed Mahros, Mohamed Salem
BACKGROUND: Left ventricular ejection fraction (LVEF) is fundamental for risk stratification after ST-segment elevation myocardial infarction (STEMI). However, it lacks discrimination power within normal range. Novel echocardiographic deformation parameters may be of benefit for those with post-MI preserved LVEF. OBJECTIVES: We hypothesized that semiautomated calculation of baseline global longitudinal strain (GLS) can identify high-risk group among patients with LVEF ≥ 50% following STEMI...
March 22, 2018: Echocardiography
https://www.readbyqxmd.com/read/29562571/value-of-three-dimensional-speckle-tracking-imaging-for-predicting-left-ventricular-function-after-non-st-segment-elevation-myocardial-infarction-with-percutaneous-coronary-intervention
#15
Yongjuan Luo, Yujie Liu, Xin Guan, Ying Zhang, Jing Li
BACKGROUND: Percutaneous coronary intervention (PCI) is the recommended treatment for high risk patients with non-ST-segment elevation myocardial infarction (NSTEMI). OBJECTIVE: To investigate the application of three dimensional-speckle tracking imaging (3D-STI) on patients diagnosed with NSTEMI undergoing PCI. METHODS: Forty-four NSTEMI patients and 20 healthy subjects that received basic clinical and laboratory examinations were included in our study...
2018: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29548538/right-heart-function-interacts-with-left-ventricular-remodeling-after-crt-a-pressure-volume-loop-study
#16
Alexander Schmeisser, Thomas Rauwolf, Ali Ghanem, Thomas Groscheck, Daniela Adolf, Frank Grothues, Katharina Fischbach, Ortrud Kosiek, Christof Huth, Siegfried Kropf, Stefan Lange, Blerim Luani, Jan Smid, Marc Henning Schäfer, Jens Schreiber, Ivan Tanev, Fabian Wengler, Naira Beniki Yeritsyan, Paul Steendijk, Ruediger C Braun-Dullaeus
BACKGROUND: Right ventricular (RV) dysfunction is recognized as a cardinal prognostic marker in systolic heart failure patients. Conflicting data exist on the interaction of RV function and left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). This prospective monocentric trial was set up to assess the predictive value of baseline RV function and corresponding RV-pulmonary artery (PA) coupling on LV reverse remodeling after CRT. METHODS: 110 patients with a CRT indication were prospectively enrolled...
March 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29536860/outcome-and-undertreatment-of-mitral-regurgitation-a-community-cohort-study
#17
Volha Dziadzko, Marie-Annick Clavel, Mikhail Dziadzko, Jose R Medina-Inojosa, Hector Michelena, Joseph Maalouf, Vuyisile Nkomo, Prabin Thapa, Maurice Enriquez-Sarano
BACKGROUND: Mitral regurgitation is the most common valve disease worldwide but whether the community-wide prevalence, poor patient outcomes, and low rates of surgical treatment justify costly development of new therapeutic interventions remains uncertain. Therefore, we did an observational cohort study to assess the clinical characteristics, outcomes, and degree of undertreatment of mitral regurgitation in a community setting. METHODS: We used data from Mayo Clinic electronic health records and the Rochester Epidemiology Project to identify all cases of moderate or severe isolated single-valvular mitral regurgitation (with no other severe left-sided valvular disease or previous mitral surgery) diagnosed during a 10-year period in the community setting in Olmsted County (MN, USA)...
March 10, 2018: Lancet
https://www.readbyqxmd.com/read/29528482/cryoballoon-ablation-of-atrial-fibrillation-in-patients-with-advanced-systolic-heart-failure-and-cardiac-implantable-electronic-devices
#18
Patrycja Pruszkowska, Radosław Lenarczyk, Jakub Gumprecht, Ewa Jedrzejczyk-Patej, Michał Mazurek, Oskar Kowalski, Adam Sokal, Tomasz Podolecki, Stanisław Morawski, Witold Streb, Katarzyna Mitręga, Zbigniew Kalarus
BACKGROUND: Pulmonary vein isolation with cryobaloon catheter ablation (CCB) is an effective method oftreatment in patients with atrial fibrillation (AF) but in patients with heart failure (HF) therole of CCB remains unknown. AIMS: To assess feasibility, effectiveness and safety of CCB in patients with HF and cardiac electronic devices (CIED), the impact of the procedure on symptoms and echocardiographic parameters. METHODS: Thirty consecutive HF patients with left ventricular ejection fraction (EF)≤40% and CIED, referred for CCB of AF were included...
March 12, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29525249/prevalence-and-predictive-value-of-microvascular-flow-abnormalities-after-successful-contemporary-percutaneous-coronary-intervention-in-acute-st-segment-elevation-myocardial-infarction
#19
Sourabh Aggarwal, Feng Xie, Robin High, Gregory Pavlides, Thomas R Porter
BACKGROUND: Although microvascular flow abnormalities have been observed following epicardial recanalization in acute ST-segment elevation myocardial infarction (STEMI), the prevalence and severity of these abnormalities in the current era of rapid percutaneous coronary intervention (PCI) has not been evaluated. The objective of this study was to assess microvascular perfusion (MVP) following successful primary PCI in patients with STEMI and how it affects clinical outcome. METHODS: In this single-center, retrospective study, 170 patients who successfully underwent emergent PCI for STEMI were assessed using real-time myocardial contrast echocardiography using a continuous infusion of intravenous commercial microbubbles (3% Definity)...
March 7, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29524314/semaphorin-4d-levels-in-heart-failure-patients-a-potential-novel-biomarker-of-acute-heart-failure
#20
Nadav Willner, Yair Goldberg, Elad Schiff, Zahava Vadasz
AIMS: Semaphorin 4D (Sema4D) is expressed on platelets and T-cells and known to be involved in inflammation. The aims of this study include comparing Sema4D and N terminal pro brain natriuretic peptide (NT-proBNP) serum levels in heart failure (HF) patients to a control group, evaluating the correlation between Sema4D and NT-proBNP levels, and assessing Sema4D serum levels in HF patients during acute exacerbation and remission. METHODS AND RESULTS: Forty-five patients diagnosed with HF (based on echocardiographic findings, positive NT-proBNP levels, and normal C-reactive protein) and 11 healthy controls (declaring no chronic diseases or medications) comprised the study population...
March 10, 2018: ESC Heart Failure
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