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Serologic profile and clinical markers of Sjögren syndrome in patients with rheumatoid arthritis

Hugo Franklin Oliveira, Thayse Rodrigues de Souza, Camila Nunes Carvalho, Angela Duarte, Alessandra Tavares Carvalho, Jair Carneiro Leão, Luiz Alcino Gueiros
OBJECTIVE: The aim of this study was to evaluate the clinical relevance of rheumatoid factor (RF) and antibodies against cyclic citrullinated peptides (anti-CCP) in patients with Sjögren syndrome (SS) secondary to rheumatoid arthritis (RA). METHODS: The study included 118 individuals, and the subjects were divided into three groups: rheumatoid arthritis (RA; n = 46), RA with secondary Sjögren syndrome (RA/SS; n = 20) and healthy controls (C; n = 52). Clinical and laboratory characteristics, including ocular, oral, and serum markers, anti-CCP, and rheumatoid factor (RF), were compared in addition to biopsy of labial minor salivary glands...
June 2015: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Vasiliki-Kalliopi Bournia, Panayiotis G Vlachoyiannopoulos
Sjögren Syndrome (SS) is a systemic, autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands. Different clinical associations have been described for each of the diverse autoantibodies found in SS patients. Antibodies directed against the Ro/La ribonucleoprotein complexes have been correlated with younger age, more severe dysfunction of the exocrine glands and a higher prevalence of extraglandular manifestations. Anti-nuclear antibodies and rheumatoid factors have been associated to extraglandular manifestations and an active immunological profile, while cryoglobulins are markers of more severe disease and correlate to lymphoma development and death...
August 2012: Journal of Autoimmunity
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