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JOURNAL ARTICLE
Timothy Phillips, Abdallah Mughrabi, Levindo J Garcia, Christopher El Mouhayyar, Laith Hattar, Hocine Tighiouart, Andrew H Moraco, Claudia Nader, Bertrand L Jaber
Purpose: This study examines whether excessive adipose tissue, as measured by the body mass index (BMI), is associated with higher systemic markers of inflammation and higher risk of severe acute organ failure among patients with coronavirus disease 2019 (COVID-19). Methods: This was a multicenter retrospective cohort study of 1370 hospitalized adults (18 years or older) with COVID-19 during the first wave of the pandemic. Patient-level variables were extracted from the electronic medical record. The primary predictor variable was the BMI at time of hospital admission, in accordance with the World Health Organization classification...
February 11, 2024: Journal of Intensive Care Medicine
#22
JOURNAL ARTICLE
Simon Corrado Serafini, David M P van Meenen, Luigi Pisani, Ary Serpa Neto, Lorenzo Ball, Marcelo Gama de Abreu, Anna Geke Algera, Luciano Azevedo, Giacomo Bellani, Arjen M Dondorp, Eddy Fan, John G Laffey, Tai Pham, Edda M Tschernko, Marcus J Schultz, Margaretha C E van der Woude
PURPOSE: We investigated driving pressure (ΔP) and mechanical power (MP) and associations with clinical outcomes in critically ill patients ventilated for reasons other than ARDS. MATERIALS AND METHODS: Individual patient data analysis of a pooled database that included patients from four observational studies of ventilation. ΔP and MP were compared among invasively ventilated non-ARDS patients with sepsis, with pneumonia, and not having sepsis or pneumonia...
February 10, 2024: Journal of Critical Care
#23
JOURNAL ARTICLE
Kebing Lv, Xiaoye Cheng, Yulan Zhou, Min Yu, Shixuan Wang, Huimin Shen, Fei Li
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) patients who need intensive care usually have multiple organ failure and poor prognosis. However, the clinical characteristics, therapeutic efficacy and outcome in these critically ill HLH patients have remained unclear. METHODS: We performed a retrospective study of 50 critically ill HLH patients from September 2013 to October 2022. Patients' information was collected, and the overall survival rate was estimated...
2024: International Journal of General Medicine
#24
JOURNAL ARTICLE
Hui-Dan Jing, Jun-Ying Tian, Wei Li, Bing-Ling He, Hong-Chao Li, Fu-Xia Jian, Cui Shang, Feng Shen
PURPOSE: To assess the value of the driving pressure variation rate (ΔP%) in predicting the outcome of weaning from invasive mechanical ventilation in patients with acute respiratory distress syndrome. METHODS: In this case-control study, a total of 35 patients with moderate-severe acute respiratory distress syndrome were admitted to the intensive care unit between January 2022 and December 2022 and received invasive mechanical ventilation for at least 48 h were enrolled...
March 2024: Chinese Journal of Traumatology
#25
JOURNAL ARTICLE
Nur Baykara
BACKGROUND: Coronaviruses have been the cause of 3 major outbreaks during the last 2 decades. Information on coronavirus diseases in pregnant women is limited, and even less is known about seriously ill pregnant women. Data are also lacking regarding the real burden of coronavirus disease 2019 (COVID-19) infection in pregnant women from low/middle-income countries. The aim of this study was to determine the characteristics and clinical course of COVID-19 in pregnant/puerperal women admitted to ICUs in Turkey...
February 6, 2024: Journal of Intensive Care Medicine
#26
JOURNAL ARTICLE
S S Zha, Z F He, L L Guan, J Y Niu, Q Y Huang, R C Chen
Non-invasive positive pressure ventilation (NPPV) is a widely used method of providing respiratory support in a variety of clinical settings, including emergency departments, general wards, and intensive care units. The relevant research articles on NPPV published between 1st October 2022 and 30th September 2023 were retrieved from Medline and reviewed. In the management of acute respiratory failure (ARF) associated with COVID-19, studies have highlighted the significant influence of regional economic status on the choice of respiratory support strategies...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
#27
REVIEW
Tayyba Naz Aslam, Andreas Barratt-Due, Arnt Eltvedt Fiane, Camilla M Friis, Kristin Hofsø, Trine Kåsine, Luis Romundstad, Jon Henrik Laake
BACKGROUND: Pregnant women with COVID-19 are probably at increased risk of serious illness. The objective of this study was to describe the course of illness in pregnant women admitted to the intensive care unit (ICU) with acute respiratory distress syndrome triggered by COVID-19. MATERIAL AND METHOD: Pregnant women with COVID-19 were registered on admission to an ICU at Rikshospitalet, Oslo University Hospital in the period March 2020 to May 2023. We reviewed the patients' medical records retrospectively and describe clinical trajectories, management parameters and laboratory data collected during the period in intensive care...
January 23, 2024: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
#28
REVIEW
Chiara Chiappero, Alessio Mattei, Luca Guidelli, Serena Millotti, Emiliano Ceccherini, Simon Oczkowski, Raffaele Scala
During the COVID-19 pandemic, the number of patients with hypoxemic acute respiratory failure (ARF) due to SARS-CoV-2 pneumonia threatened to overwhelm intensive care units. To reduce the need for invasive mechanical ventilation (IMV), clinicians tried noninvasive strategies to manage ARF, including the use of awake prone positioning (PP) with continuous positive airway pressure (CPAP). In this article, we review the patho-physiologic rationale, clinical effectiveness and practical issues of the use of PP during CPAP in non-intubated, spontaneously breathing patients affected by SARS-CoV-2 pneumonia with ARF...
2024: Therapeutic Advances in Respiratory Disease
#29
JOURNAL ARTICLE
María Martínez Martínez, Matthieu Schmidt, Lars Mikael Broman, Roberto Roncon-Albuquerque, Elise Langouet, Isabel Campos, Eduard Argudo, Josep Maria Domènech Vila, Sara Martín Sastre, Elisabet Gallart, Ricard Ferrer, Alain Combes, Jordi Riera
Rationale Severe cases of acute respiratory distress syndrome (ARDS) may require prolonged (>28 days) extracorporeal membrane oxygenation (ECMO). In non-resolving disease, recovery is uncertain and lung transplant may be proposed. Objective This study aims to identify the variables influencing survival and to describe the functional status of these patients at six months. Methods Retrospective multicentre observational cohort study including patients requiring ECMO support for COVID-19 related ARDS for more than 28 days...
December 22, 2023: Annals of the American Thoracic Society
#30
JOURNAL ARTICLE
Guillaume Franchineau, Annemijn H Jonkman, Lise Piquilloud, Takeshi Yoshida, Eduardo Costa, Hadrien Rozé, Luigi Camporota, Thomas Piraino, Elena Spinelli, Alain Combes, Glasiele C Alcala, Marcelo Amato, Tommaso Mauri, Inéz Frerichs, Laurent J Brochard, Matthieu Schmidt
Hypoxemic respiratory failure is one of the leading causes of mortality in intensive care. Frequent assessment of individual physiological characteristics and delivering personalized mechanical ventilation settings is a constant challenge for clinicians caring for these patients. Electrical impedance tomography (EIT) is a bedside and radiation-free monitoring device able to assess regional lung ventilation and changes in aeration. Through a thoracic belt with real-time tomographic functional images of the lungs, clinicians can visualize and estimate the distribution of ventilation at different ventilation settings or following procedures such as prone positioning...
December 21, 2023: American Journal of Respiratory and Critical Care Medicine
#31
JOURNAL ARTICLE
Zahra Sahraei, Parnaz Panahi, Kouroush Solhjoukhah, Maryam Mesbah, Siamak Afaghi, Mahdi Amirdosara, Jamshid Salamzadeh, Farzad Esmaeili Tarki, Ilad Alavi Darazam
BACKGROUND: It remains unclear which formulation of the corticosteroid regimen has the optimum efficacies on COVID-19 pneumonia. OBJECTIVES: The aim of this study was to compare the clinical outcomes of 2 different regimens in the treatment of acute respiratory distress syndrome (ARDS) caused by COVID-19: Methylprednisolone at a dose of 1 mg/kg every 12 hours (low-dose group) and 1000 mg/day pulse therapy for 3 days following 1 mg/kg methylprednisolone every 12 hours (high-dose group)...
2023: Iranian Journal of Pharmaceutical Research: IJPR
#32
Sadaf Hanif Musani, Muhammad Mehmood Alam, Asad Latif
Covid-19 pandemic affected the health care systems globally. In many countries, healthcare services were overwhelmed by the huge number of Covid cases; hence, shifting the focus from locally endemic infectious diseases. Such a case presented to us that was initially managed along the lines of critical Covid pneumonia with steroids, Remdesivir, and supplemental oxygen for hypoxic respiratory failure. The patient also received Baricitinib, to which he was non-responsive and thus offered invasive mechanical ventilation...
December 2023: JPMA. the Journal of the Pakistan Medical Association
#33
JOURNAL ARTICLE
Anna Brugnolli, Gabriele Chini, Riccardo Scartezzini, Elisa Ambrosi
INTRODUCTION: Non-invasive ventilation (NIV) treatment combined with pronation in patients with COVID-19 respiratory failure has been shown to be effective in improving respiratory function and better patient outcomes. These patients may experience discomfort or anxiety that may reduce adherence to treatment. OBJECTIVE: The aim of this study was to explore and describe the subjective experiences of patients undergoing helmet NIV and pronation during hospitalisation for COVID-19 respiratory failure, with a focus on the elements of care and strategies adopted by patients that enabled good adaptation to treatments...
December 9, 2023: BMJ Open
#34
JOURNAL ARTICLE
Carlos Ferrando, Albert Carramiñana, Patricia Piñeiro, Lucia Mirabella, Savino Spadaro, Julián Librero, Fernando Ramasco, Gaetano Scaramuzzo, Oriol Cervantes, Ignacio Garutti, Ana Parera, Marta Argilaga, Gracia Herranz, Carmen Unzueta, Marc Vives, Kevin Regi, Marta Costa-Reverte, María Sonsoles Leal, Jesús Nieves-Alonso, Esther García, Aurelio Rodríguez-Pérez, Roberto Fariña, Sergio Cabrera, Elisabeth Guerra, Lucia Gallego-Ligorit, Alba Herrero-Izquierdo, J Vallés-Torres, Silvia Ramos, Daniel López-Herrera, Manuel De La Matta, Sertcakacilar Gokhan, Evrim Kucur, Ana Mugarra, Marina Soro, Laura García, José Alfonso Sastre, Pilar Aguirre, Claudia Jimena Salazar, María Carolina Ramos, Diego Rolando Morocho, Ramón Trespalacios, Félix Ezequiel-Fernández, Angella Lamanna, Leonarda Pia Cantatore, Donato Laforgia, Soledad Bellas, Carlos López, Ricard Navarro-Ripoll, Samira Martínez, Jordi Vallverdú, Adriana Jacas, María José Yepes-Temiño, Francisco Javier Belda, Gerardo Tusman, Fernando Suárez-Sipmann, Jesús Villar
BACKGROUND: It is uncertain whether individualisation of the perioperative open-lung approach (OLA) to ventilation reduces postoperative pulmonary complications in patients undergoing lung resection. We compared a perioperative individualised OLA (iOLA) ventilation strategy with standard lung-protective ventilation in patients undergoing thoracic surgery with one-lung ventilation. METHODS: This multicentre, randomised controlled trial enrolled patients scheduled for open or video-assisted thoracic surgery using one-lung ventilation in 25 participating hospitals in Spain, Italy, Turkey, Egypt, and Ecuador...
December 5, 2023: Lancet Respiratory Medicine
#35
JOURNAL ARTICLE
K Xiao, L X Xie
This article reviewed the clinical progress in the field of pulmonary and critial care medicine, both domestically and internationally during the year 2023 (from October 1, 2022 to September 30, 2023). In 2023, there have been significant modifications to the global definition of Acute Respiratory Distress Syndrome (ARDS). These include the inclusion of SpO2 /FiO2 as a diagnostic criterion for ARDS, the addition of parameters for high-flow nasal cannula humidified oxygen therapy as a basis for diagnosing ARDS in non-intubated patients, clarification of the need to diagnose ARDS in non-intubated patients with PEEP≥5 cmH2 O under non-invasive positive pressure ventilation, and the increased diagnostic value of ultrasound...
December 8, 2023: Chinese Journal of Tuberculosis and Respiratory Diseases
#36
JOURNAL ARTICLE
Svetlana Herasevich, Phillip J Schulte, William J Hogan, Hassan Alkhateeb, Zhenmei Zhang, Bradley A White, Nandita Khera, Vivek Roy, Ognjen Gajic, Hemang Yadav
RATIONALE: Pulmonary complications contribute significantly to non-relapse mortality following hematopoietic stem cell transplantation (HCT). Identifying high-risk patients can help enroll such patients into clinical studies to better understand, prevent and treat post-transplant respiratory failure syndromes. OBJECTIVE: Develop and validate a prediction model to identify those at increased risk of acute respiratory failure after HCT. METHODS: Patients underwent HCT between January 1, 2019, and December 31, 2021...
December 5, 2023: American Journal of Respiratory and Critical Care Medicine
#37
JOURNAL ARTICLE
(no author information available yet)
As patients with critical respiratory diseases suffer from the discomfort of disease, frequent medical and nursing procedures, and the noise disturbance of the ICU environment, it is necessary to implement analgesia and sedation to reduce their negative stress and oxygen consumption. Special emphasis will be placed on the clinical practice of analgesia, sedation and rehabilitation in critically ill patients with respiratory diseases, as different pathophysiological features of the respective pulmonary diseases are presented, such as severe asthma and acute exacerbations of chronic obstructive pulmonary disease, as well as the exclusive situations during respiratory therapy, such as recruitment maneuvers, bedside bronchoscopy and operation of extracorporeal membrane oxygenators...
December 12, 2023: Chinese Journal of Tuberculosis and Respiratory Diseases
#38
JOURNAL ARTICLE
Helena Milton-Jones, Sabri Soussi, Roger Davies, Emmanuel Charbonney, Walton N Charles, Heather Cleland, Ken Dunn, Dashiell Gantner, Julian Giles, Marc Jeschke, Nicole Lee, Matthieu Legrand, Joanne Lloyd, Ignacio Martin-Loeches, Olivier Pantet, Mark Samaan, Odhran Shelley, Alice Sisson, Kaisa Spragg, Fiona Wood, Jeremy Yarrow, Marcela Paola Vizcaychipi, Andrew Williams, Jorge Leon-Villapalos, Declan Collins, Isabel Jones, Suveer Singh
BACKGROUND: Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelines, no consensus exists for the best strategies regarding diagnosis and management of BII. A modified DELPHI study using the RAND/UCLA (University of California, Los Angeles) Appropriateness Method (RAM) systematically analysed the opinions of an expert panel. Expert opinion was combined with available evidence to determine what constitutes appropriate and inappropriate judgement in the diagnosis and management of BII...
November 27, 2023: Critical Care: the Official Journal of the Critical Care Forum
#39
JOURNAL ARTICLE
Md Habibullah Sk, Bijan Saha
BACKGROUND: Less invasive surfactant administration (LISA) results in less need for mechanical ventilation and a reduction in death, bronchopulmonary dysplasia, and intraventricular hemorrhage as outcomes. This study aimed to evaluate the efficacy and short-term outcomes of surfactant administration by the LISA method using an 5F infant feeding tube in preterm infants. METHODS: During the period from May, 2019 to August, 2022, we carried out a prospective observational study that included all premature infants with respiratory distress syndrome who were admitted to our neonatal intensive care unit...
2023: Pediatrics International: Official Journal of the Japan Pediatric Society
#40
JOURNAL ARTICLE
Sumalatha Arunachala, Ashwaghosha Parthasarathi, Chetak Kadabasal Basavaraj, Mohammed Kaleem Ullah, Shreya Chandran, Hariharan Venkataraman, Prashant Vishwanath, Koustav Ganguly, Swapna Upadhyay, Padukudru Anand Mahesh
The use of the Ratio of Oxygen Saturation (ROX) index to predict the success of high-flow nasal oxygenation (HFNO) is well established. The ROX can also predict the need for intubation, mortality, and is easier to calculate compared with APACHE II. In this prospective study, the primary aim is to compare the ROX (easily administered in resource limited setting) to APACHE II for clinically relevant outcomes such as mortality and the need for intubation. Our secondary aim was to identify thresholds for the ROX index in predicting outcomes such as the length of ICU stay and failure of non-invasive respiratory support therapies and to assess the effectiveness of using the ROX (day 1 at admission, day 2, and day 3) versus Acute physiology and chronic health evaluation (APACHE) II scores (at admission) in patients with Coronavirus Disease 2019 (COVID-19) pneumonia and Acute Respiratory Distress Syndrome (ARDS) to predict early, late, and non-responders...
November 8, 2023: Viruses
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