keyword
https://read.qxmd.com/read/38454423/pediatric-sepsis-inflammatory-blood-biomarkers-that-correlate-with-clinical-variables-and-severity-of-illness-scores
#21
JOURNAL ARTICLE
Sean Leonard, Hailey Guertin, Natalya Odoardi, Michael R Miller, Maitray A Patel, Mark Daley, Gediminas Cepinskas, Douglas D Fraser
BACKGROUND: Sepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in clinical pediatrics is to identify sepsis early and then quickly intervene to reduce morbidity and mortality. As blood biomarkers hold promise as early sepsis diagnostic tools, we aimed to measure a large number of blood inflammatory biomarkers from pediatric sepsis patients to determine their predictive ability, as well as their correlations with clinical variables and illness severity scores...
March 7, 2024: Journal of Inflammation
https://read.qxmd.com/read/38454348/bioinformatics-analysis-identifies-a-key-gene-hla_dpa1-in-severe-influenza-associated-immune-infiltration
#22
JOURNAL ARTICLE
Liang Chen, Jie Hua, Xiaopu He
BACKGROUND: Severe influenza is a serious global health issue that leads to prolonged hospitalization and mortality on a significant scale. The pathogenesis of this infectious disease is poorly understood. Therefore, this study aimed to identify the key genes associated with severe influenza patients necessitating invasive mechanical ventilation. METHODS: The current study utilized two publicly accessible gene expression profiles (GSE111368 and GSE21802) from the Gene Expression Omnibus database...
March 7, 2024: BMC Genomics
https://read.qxmd.com/read/38454232/comparison-of-the-efficacies-of-high-flow-nasal-cannula-oxygen-therapy-and-non-invasive-nasal-cannula-ventilation-in-preventing-intubation
#23
JOURNAL ARTICLE
Ülkem Koçoğlu Barlas, Abdulrahman Özel, Volkan Tosun, Emine Ufuk Bozkurt, Hasan Serdar Kıhtır
OBJECTIVE: This study aimed to compare high-flow nasal cannula oxygen therapy (nc-HFOT) and non-invasive nasal cannula ventilation (nc-NIV) in terms of intubation requirements. MATERIALS AND METHODS: The study was conducted retrospectively on cases followed up in the pediatric intensive care unit (PICU) between October 2019 and December 2021. RESULTS: Of all cases, 43 (55.8%) were male, and the median age was 16 months. The median PRISM-3 score for all cases was 2...
March 2024: Turkish archives of pediatrics
https://read.qxmd.com/read/38452638/anesthetic-management-of-thyroid-carcinoma-invading-the-upper-tracheal-segment-a-case-report
#24
Yuyan Ding, Lianbing Gu, Lijun Wang, Lingxi Xing, Yihu Zhou, Yueyi Jiang
INTRODUCTION AND IMPORTANCE: Intratracheal tumors account for approximately 0.2 % of respiratory tumors, including primary and secondary tumors. Secondary tumors of the upper trachea are most commonly derived from advanced thyroid cancer. Surgical resection is currently the general curative modality for thyroid cancer with tracheal invasion. Patients with tracheal tumors invading and protruding into the lumen may have reduced oxygen reserve capacity, leading to a shorter safe window for general anesthesia induction...
February 27, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38452031/temporal-trends-of-severity-and-outcomes-of-critically-ill-patients-with-covid-19-after-the-emergence-of-variants-of-concern-a-comparison-of-two-waves
#25
JOURNAL ARTICLE
Daniela Helena Machado Freitas, Eduardo Leite Vieira Costa, Natalia Alcantara Zimmermann, Larissa Santos Oliveira Gois, Mirella Vittig Alves Anjos, Felipe Gallego Lima, Pâmela Santos Andrade, Daniel Joelsons, Yeh-Li Ho, Flávia Cristina Silva Sales, Ester Cerdeira Sabino, Carlos Roberto Ribeiro Carvalho, Juliana Carvalho Ferreira
BACKGROUND: The emergence of SARS-CoV-2 variants led to subsequent waves of COVID-19 worldwide. In many countries, the second wave of COVID-19 was marked by record deaths, raising the concern that variants associated with that wave might be more deadly. Our aim was to compare outcomes of critically-ill patients of the first two waves of COVID-19. METHODS: This retrospective cohort included critically-ill patients admitted between March-June 2020 and April-July 2021 in the largest academic hospital in Brazil, which has free-access universal health care system...
2024: PloS One
https://read.qxmd.com/read/38450129/comparing-covid-19-severity-in-patients-hospitalized-for-community-associated-delta-ba-1-and-ba-4-5-variant-infection
#26
JOURNAL ARTICLE
Maja Sočan, Maja Mrzel, Katarina Prosenc, Miša Korva, Tatjana Avšič-Županc, Mario Poljak, Maja M Lunar, Tina Zupanič
BACKGROUND: Despite decreasing COVID-19 disease severity during the Omicron waves, a proportion of patients still require hospitalization and intensive care. OBJECTIVE: To compare demographic characteristics, comorbidities, vaccination status, and previous infections in patients hospitalized for community-associated COVID-19 (CAC) in predominantly Delta, Omicron BA.1 and BA.4/5 SARS-CoV-2 waves. METHODS: Data were extracted from three national databases-the National COVID-19 Database, National Vaccination Registry and National Registry of Hospitalizations...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38449975/intensive-care-management-of-an-adult-patient-with-rare-chilaiditi-syndrome-presenting-as-abdominal-breathing-a-case-report
#27
Gulseren Yilmaz, Kubra Mentese, Pelin Kilic Erol, Bedih Balkan, Ummihan Topal
Chilaiditi syndrome (CS) is an uncommon case of the asymptomatic radiographic finding of an intestinal loop between the liver and the diaphragm. The most crucial phases in the diagnosis process are a thorough physical examination and precise imaging, particularly in challenging disorders such as CS. The presence of free air under the right hemidiaphragm in this syndrome, the diagnosis of which is based on radiographic imaging, might direct the start of treatment without the need for surgical intervention. An 86-year-old man, with asthma and chronic obstructive pulmonary disease (COPD) was checked out in our hospital's emergency department (ED) after experiencing nausea and vomiting...
February 2024: Curēus
https://read.qxmd.com/read/38449669/investigating-the-association-between-dynamic-driving-pressure-and-mortality-in-covid-19-related-acute-respiratory-distress-syndrome-a-joint-modeling-approach-using-real-time-continuously-monitored-ventilation-data
#28
JOURNAL ARTICLE
Daniel J Tan, Joseph M Plasek, Peter C Hou, Rebecca M Baron, Benjamin J Atkinson, Li Zhou
IMPORTANCE AND OBJECTIVES: COVID-19-related acute respiratory distress syndrome (ARDS) is associated with high mortality and often necessitates invasive mechanical ventilation (IMV). Previous studies on non-COVID-19 ARDS have shown driving pressure to be robustly associated with ICU mortality; however, those studies relied on "static" driving pressure measured periodically and manually. As "continuous" automatically monitored driving pressure is becoming increasingly available and reliable with more advanced mechanical ventilators, we aimed to examine the effect of this "dynamic" driving pressure in COVID-19 ARDS throughout the entire ventilation period...
March 2024: Critical care explorations
https://read.qxmd.com/read/38448999/predicting-sepsis-in-hospital-mortality-with-machine-learning-a-multi-center-study-using-clinical-and-inflammatory-biomarkers
#29
MULTICENTER STUDY
Guyu Zhang, Fei Shao, Wei Yuan, Junyuan Wu, Xuan Qi, Jie Gao, Rui Shao, Ziren Tang, Tao Wang
BACKGROUND: This study aimed to develop and validate an interpretable machine-learning model that utilizes clinical features and inflammatory biomarkers to predict the risk of in-hospital mortality in critically ill patients suffering from sepsis. METHODS: We enrolled all patients diagnosed with sepsis in the Medical Information Mart for Intensive Care IV (MIMIC-IV, v.2.0), eICU Collaborative Research Care (eICU-CRD 2.0), and the Amsterdam University Medical Centers databases (AmsterdamUMCdb 1...
March 6, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38448335/minimally-invasive-airway-management-and-early-cleft-palate-repair-in-infants-born-with-robin-sequence
#30
JOURNAL ARTICLE
Catherine de Blacam, Daryl Butler, Laura Duggan, Sandra Byrne, John Russell, Sheila Javadpour, Martin White, David J A Orr
The objective of this study was to report outcomes of early cleft palate repair in infants born with Robin sequence (RS). A retrospective case series in a tertiary referral paediatric hospital was carried out, examining a consecutive series of 69 infants born with RS and cleft palate. A minimally invasive approach was taken to upper airway obstruction, with liberal nasopharyngeal airway (NPA) and non-invasive ventilation (NIV) use, guided by sleep studies. The palate was repaired between 6 and 9 months with a modified Malek technique...
February 11, 2024: Journal of Cranio-maxillo-facial Surgery
https://read.qxmd.com/read/38445550/covid-19-infection-in-patients-with-history-of-pediatric-heart-transplant-in-germany-austria-and-switzerland
#31
JOURNAL ARTICLE
Sarah Ulrich, Christian Balmer, Kolja Becker, Josefin Bruhs, Friederike Danne, Volker Debus, Leonie Dewein, Stefano Di-Bernardo, Ulrike Doll, Thilo Fleck, Theodor Tirilomis, Martin Glöckler, Maria Grafmann, Sabine Greil, Urte Grosser, Patrick Saur, Susanne Skrzypek, Michael Steinmetz
COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric heart transplant centers in Germany, Austria and Switzerland to evaluate the risk of a severe COVID-19 infection after pediatric heart transplantation between 02/2020 and 06/2021. Twenty-six subjects (11 male) with a median age of 9...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38444560/kyphoscoliosis-complicating-asthma-with-fixed-airway-obstruction
#32
Sarah Bonello, Yanika Farrugia, Theresa Mallia, Nicoletta Maniscalco, Martin Balzan
INTRODUCTION: Kyphoscoliosis is present in up to 2% of the juvenile population and can have deleterious effects on respiratory mechanics, leading to chronic respiratory failure later on in adult life. CASE PRESENTATION: Hereby we describe a 53-year-old patient with severe uncontrolled asthma who presented with chronic hypercapnic respiratory failure. During her medical workup, she was noted to have several comorbidities leading to her respiratory failure. The patient had radiological evidence of bronchiectasis with recurrent episodes of infection, and a severe deformity of the spine due to Kyphoscoliosis...
February 6, 2024: Multidisciplinary Respiratory Medicine
https://read.qxmd.com/read/38442931/-clinical-significance-of-negative-fluid-balance-and-infection-management-in-the-treatment-of-acute-respiratory-distress-syndrome-caused-by-severe-novel-coronavirus-infection
#33
JOURNAL ARTICLE
Zhigang Li, Taizu Zheng, Yinjun Zhang, Zhenchen Li, Xingyan Ling
OBJECTIVE: To explore the clinical significance of negative fluid balance and infection management in the treatment of acute respiratory distress syndrome (ARDS) caused by severe novel coronavirus infection. METHODS: A retrospective survey was conducted. Patients with ARDS caused by severe novel coronavirus infection who were hospitalized in the department of critical care medicine of the Third Affiliated Hospital of Gansu University of Chinese Medicine and received non-invasive ventilator assisted ventilation were selected as the research objects...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38442929/-impact-of-extracorporeal-carbon-dioxide-removal-combined-with-continuous-renal-replacement-therapy-on-diaphragmatic-function-in-patients-with-acute-respiratory-distress-syndrome
#34
JOURNAL ARTICLE
Xingang Hu, Wenwen Zhang, Yafen Jiang, Jie Zhang, Zhida Liu, Cuijie Tian, Xuelin Wang, Jianjian Cheng
OBJECTIVE: To investigate the effects of extracorporeal carbon dioxide removal (ECCO2 R) combined with continuous renal replacement therapy (CRRT) on respiratory efficiency and diaphragm function in patients with acute respiratory distress syndrome (ARDS) received mechanical ventilation. METHODS: A prospective randomized controlled study was conducted. Sixty patients with mild to moderate ARDS admitted to the department of respiratory and critical care medicine of Henan Provincial People's Hospital from January 2019 to January 2021 were enrolled, and they were divided into observation group and control group according to the random number table method, with 30 cases in each group...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38440333/factors-in-the-neonatal-period-associated-with-pulmonary-hypertension-at-28%C3%A2-days-of-life-in-broncho-pulmonary-dysplasia
#35
JOURNAL ARTICLE
Nguyen Thi Hai Anh, Tran Minh Dien, Le Thi Ha, Pham Thao Nguyen, Dang Thi Hai Van
Objectives. To identify factors associated with pulmonary hypertension (PH) at 28 days of life in preterm infants with bronchopulmonary dysplasia (BPD). Methods . This observational study included 128 premature infants with BPD between January 2022 and February 2023 from the neonatal intensive care unit of Vietnam National Children's Hospital. Results . PH was observed using echocardiography in 29 patients (22.66%). The prevalence of severe BPD in the PH group (62.07%) was significantly higher than that in the non-PH group (18...
2024: Global Pediatric Health
https://read.qxmd.com/read/38435954/carotid-blood-flow-as-a-surrogate-for-pulse-contour-analysis-in-assessment-of-fluid-responsiveness-a-prospective-observational-single-centre-study-contour-study
#36
JOURNAL ARTICLE
Anirban Karmarkar, Divya Pal, Deepak Govil, Sweta J Patel, Jagadeesh Kn, Rahul Harne, Anant Vikram Pachisia, Pooja Tyagi, Devireddy Madhav Reddy, Keerti Brar
Background and objectives The quest for an accurate and reliable non-invasive method of assessing cardiac output in critically ill patients is still ongoing. Carotid artery Doppler is a promising non-invasive, reproducible, and feasible bedside monitor. So we compared the change in cardiac output derived from arterial pressure waveforms (pulse contour analysis) with that from carotid artery Doppler-derived measurements, in post-major elective abdominal surgery patients. Materials and methods We conducted a prospective observational study in 30 adult post-major elective abdominal surgery patients admitted to the Gastroenterology and Liver Transplant intensive care unit postoperatively on mechanical ventilator support, who were found to be fluid responsive clinically on passive leg raise (PLR) test...
January 2024: Curēus
https://read.qxmd.com/read/38431557/clinical-trends-among-patients-with-asthma-hospitalized-for-covid-19-based-on-data-from-a-nationwide-database-an-observational-study
#37
JOURNAL ARTICLE
Akinari Tsukada, Junko Terada-Hirashima, Jin Takasaki, Hiroshi Nokihara, Shinyu Izumi, Masayuki Hojo, Haruhito Sugiyama
BACKGROUND: While the prevalence of severe cases and mortality rate of coronavirus disease 2019 (COVID-19) appear to be reducing, the clinical characteristics and severity of hospitalized patients with asthma and COVID-19 remain largely unknown. This study aimed to examine the association of asthma with COVID-19 severity and mortality risk. METHODS: Data from the Japanese COVID-19 Registry Database were used to investigate the association between COVID-19 and asthma...
March 2, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38430175/assessment-of-non-invasive-ventilation-combined-with-naloxone-for-the-management-of-acute-respiratory-failure-in-patients-with-chronic-obstructive-pulmonary-disease
#38
JOURNAL ARTICLE
Xiaofang Chen, Xiaohua Wu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) poses a significant global health burden. Finding effective interventions for COPD is crucial to alleviating this health burden and enhancing patient outcomes and quality of life. OBJECTIVE: This study aimed to evaluate the therapeutic efficacy of the combination of non-invasive ventilation and naloxone in the management of acute respiratory failure among patients with COPD. METHODS: A retrospective analysis was conducted on the clinical data of 102 COPD patients experiencing acute respiratory failure who were treated at our hospital between October 2020 and October 2022...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38429656/characteristics-of-the-most-severely-ill-and-injured-patients-in-a-norwegian-helicopter-emergency-medical-service-a-retrospective-cohort-study
#39
JOURNAL ARTICLE
Eirik Ringen, Helge Haugland, Jostein Rødseth Brede
BACKGROUND: Physician-staffed helicopter emergency medical services (HEMS) are dispatched to a variety of incidents, ranging from less serious to life-threatening. The skillset of a physician may be important to provide appropriate care for the most critically ill and severely injured patients. A better understanding of these patients may therefore be important to optimize dispatch criteria, training, and equipment setups for HEMS units. The aim of this study was to describe the characteristics of patients with the national advisory committee on aeronautics (NACA) score 5 and 6, primarily by diagnostic group and interventions performed...
March 2, 2024: BMC Emergency Medicine
https://read.qxmd.com/read/38428330/position-paper-of-diagnosis-and-treatment-of-post-extubation-laryngitis-in-a-multidisciplinary-expert-based-opinion
#40
JOURNAL ARTICLE
Débora Bressan Pazinatto, Rebecca Maunsell, Melissa Ameloti Gomes Avelino, Jose Faibes Lubianca Neto, Cláudia Schweiger, Jamil Pedro de Siqueira Caldas, Marcelo Barciela Brandão, Paula Pires de Souza, Fernanda Aparecida de Oliveira Peixoto, Claudia Pires Ricachinevsky, Rita C Silveira, Cinara Andreolio, Carolina Sponchiado Miura, Daniele da Silva Jordan Volpe, Walusa Assad Gonçalves Ferri, Fabiano Bleggi Gavazzoni, Paulo Ramos David João, Silmara Aparecida Possas, Carlos Takahiro Chone
OBJECTIVES: To make recommendations on the diagnosis and treatment of post-extubation laryngitis (PEL) in children with or without other comorbidities. METHODS: A three-iterative modified Delphi method was applied. Specialists were recruited representing pediatric otolaryngologists, pediatric and neonatal intensivists. Questions and statements approached topics encompassing definition, diagnosis, endoscopic airway evaluation, risk factors, comorbidities, management, and follow-up...
February 22, 2024: Brazilian Journal of Otorhinolaryngology
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