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https://www.readbyqxmd.com/read/29241223/tumour-sidedness-and-intrinsic-subtypes-in-patients-with-stage-ii-iii-colon-cancer-analysis-of-nsabp-c-07-nrg-oncology
#1
S Rim Kim, Nan Song, Greg Yothers, Patrick G Gavin, Carmen J Allegra, Soonmyung Paik, Katherine L Pogue-Geile
BACKGROUND: We tested the association of colon tumour sidedness with prognosis and with molecular subtypes recently shown to be predictive of oxaliplatin benefit in stage III colon cancer. METHODS: NSABP/NRG C-07 trial (N=1603) was used to determine association of tumour sidedness with molecular subtypes and recurrence-free survival (RFS) and overall survival (OS). RESULTS: Sidedness was associated with molecular subtypes except stem-like/CMS4 subtype...
December 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29241222/flavopiridol-enhances-abt-199-sensitivity-in-unfavourable-risk-multiple-myeloma-cells-in-vitro-and-in-vivo
#2
Liang Zhou, Yu Zhang, Deepak Sampath, Joel Leverson, Yun Dai, Maciej Kmieciak, Matthew Nguyen, Robert Z Orlowski, Steven Grant
BACKGROUND: The BCL-2-specific BH3-mimetic ABT-199 (venetoclax) has been reported to be principally active against favourable-risk multiple myeloma (MM) cells, prompting efforts to extend its activity to include more resistant, higher-risk MM subsets. METHODS: Effects of the CDK9 inhibitor flavopiridol (FP; alvocidib) on responses to ABT-199 were examined in MM cells. Cell death and protein expression were evaluated by western blot and immunofluorescence. Xenograft models were used to study combination effects in vivo...
December 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29240844/correction-computational-and-biological-evidences-on-the-serotonergic-involvement-of-setacn-antidepressant-like-effect-in-mice
#3
Mariana G Fronza, Lucimar M Pinto Brod, Angela Maria Casaril, Manoela Sacramento, Diego Alves, Lucielli Savegnago
[This corrects the article DOI: 10.1371/journal.pone.0187445.].
2017: PloS One
https://www.readbyqxmd.com/read/29240832/correction-short-term-leprosy-forecasting-from-an-expert-opinion-survey
#4
Michael S Deiner, Lee Worden, Alex Rittel, Sarah F Ackley, Fengchen Liu, Laura Blum, James C Scott, Thomas M Lietman, Travis C Porco
[This corrects the article DOI: 10.1371/journal.pone.0182245.].
2017: PloS One
https://www.readbyqxmd.com/read/29240827/diagnostic-accuracy-research-in-glaucoma-is-still-incompletely-reported-an-application-of-standards-for-reporting-of-diagnostic-accuracy-studies-stard-2015
#5
Manuele Michelessi, Ersilia Lucenteforte, Alba Miele, Francesco Oddone, Giada Crescioli, Valeria Fameli, Daniël A Korevaar, Gianni Virgili
BACKGROUND: Research has shown a modest adherence of diagnostic test accuracy (DTA) studies in glaucoma to the Standards for Reporting of Diagnostic Accuracy Studies (STARD). We have applied the updated 30-item STARD 2015 checklist to a set of studies included in a Cochrane DTA systematic review of imaging tools for diagnosing manifest glaucoma. METHODS: Three pairs of reviewers, including one senior reviewer who assessed all studies, independently checked the adherence of each study to STARD 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29240615/enhancement-and-suppression-of-ionisation-in-drug-analysis-using-hplc-ms-ms-in-support-of-therapeutic-drug-monitoring-a-review-of-current-knowledge-of-its-minimisation-and-assessment
#6
Rani George, Alison Haywood, Sohil Khan, Mirjana Radovanovic, Joshua Simmonds, Ross Norris
High-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) is commonly used for quantitation of analytes in biological matrices, due to the selectivity, sensitivity, and high throughput offered by this technique. However, the presence of both suppression and enhancement of ionization (SEI) by matrix components is an increasingly recognized impediment to accurate results. The existence of SEI indicates that ionization efficiency is a result of the chemical environment seen by both the analyte and internal standard during ion formation...
December 11, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29240613/assessing-the-knowledge-skills-and-abilities-of-public-health-professionals-in-big-city-governmental-health-departments
#7
Meghan D McGinty, Brian C Castrucci, Debra M Rios
OBJECTIVE: To identify essential knowledge, skills, and abilities (KSAs) for and characterize gaps in KSAs of professionals working in large, urban health departments. DESIGN: A survey was disseminated to potentially eligible supervisors within 26 of 28 health departments in the largest, most urban jurisdictions in the country. A supervisor was eligible to participate if he or she supervised at least 1 staff member whose highest level of education was a master's degree...
December 13, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29240606/genetic-studies-of-human-neuropathic-pain-conditions-a-review
#8
Katerina Zorina-Lichtenwalter, Marc Parisien, Luda Diatchenko
Numerous studies have shown associations between genetic variants and neuropathic pain disorders. Rare monogenic disorders are caused by mutations of substantial effect size in a single gene, whereas common disorders are likely to have a contribution from multiple genetic variants of mild effect size, representing different biological pathways. In this review, we survey the reported genetic contributors to neuropathic pain and submit them for validation in a 150,000-participant sample of the U.K. Biobank cohort...
November 3, 2017: Pain
https://www.readbyqxmd.com/read/29240566/a-practical-clinical-approach-to-utilize-cardiopulmonary-exercise-testing-in-the-evaluation-and-management-of-coronary-artery-disease-a-primer-for-cardiologists
#9
Sundeep Chaudhry, Ross Arena, Deepak L Bhatt, Subodh Verma, Naresh Kumar
PURPOSE OF REVIEW: There is growing clinical interest for the use of cardiopulmonary exercise testing (CPET) to evaluate patients with or suspected coronary artery disease (CAD). With mounting evidence, this concise review with relevant teaching cases helps to illustrate how to integrate CPET data into real world patient care. RECENT FINDINGS: CPET provides a novel and purely physiological basis to identify cardiac dysfunction in symptomatic patients with both obstructive-CAD and nonobstructive-CAD (NO-CAD)...
December 13, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29240018/allergic-reaction-caused-by-a-lip-balm-flavored-facemask-used-during-inhalational-induction-a-case-report
#10
Youngok J Park, Priti G Dalal, Monique Mostert, Tracy Fausnight
Flavoring a facemask with a lip balm for inhalational induction in children is a common practice. However, most anesthesia providers are unaware of potential complications and the management of allergic reactions caused by lip balm. We describe the occurrence of allergic reaction to lip balm-flavored facemask in a child who underwent an inhalational anesthetic induction. The facial rash resolved completely without complications after administration of an antihistamine and steroid.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4...
December 11, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29240012/surgical-treatment-of-chronic-elbow-dislocation-allowing-early-range-of-motion-operative-technique-and-clinical-results
#11
Duane R Anderson, Justin M Haller, Lucas A Anderson, Samuel Hailu, Abebe Chala, Shawn W O'Driscoll
OBJECTIVES: Describe the surgical treatment and patient outcomes of chronic elbow dislocations. DESIGN: Retrospective review SETTING:: Two tertiary referral centers. PATIENTS/PARTICIPANTS: All patients with surgically treated chronic elbow dislocation with no associated articular fracture from January 2009 - January 2015. INTERVENTION: Review of patient demographics, injury chronicity, surgical technique, and patient outcomes...
December 6, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29240004/synchronizing-gait-with-cardiac-cycle-phase-alters-heart-rate-response-during-running
#12
Keren Constantini, Abigail S L Stickford, Jeffery L Bleich, Paul D Mannheimer, Benjamin D Levine, Robert F Chapman
Timing foot strike to occur in synchrony with cardiac diastole may reduce left ventricular afterload and promote coronary and skeletal muscle perfusion. PURPOSE: To assess heart rate (HR) and metabolic responses to running when foot strikes are timed to occur exclusively during 1) the systolic phase of the cardiac cycle, or 2) the diastolic phase. METHODS: Ten elite male distance runners performed a testing session on a treadmill at 4.72 m[BULLET OPERATOR]s while matching their steps to an auditory tone and wearing a chest strap that transmitted accelerometer and ECG signals...
December 12, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29239915/preclinical-assessment-of-car-t-cell-therapy-targeting-the-tumor-antigen-5t4-in-ovarian-cancer
#13
Gemma L Owens, Victoria E Sheard, Milena Kalaitsidou, Daniel Blount, Yatish Lad, Eleanor J Cheadle, Richard J Edmondson, Gurdeep Kooner, David E Gilham, Richard Harrop
Chimeric antigen receptor (CAR) T cells represent a novel targeted approach to overcome both quantitative and qualitative shortfalls of the host immune system relating to the detection and subsequent destruction of tumors. The identification of antigens expressed specifically on the surface of tumor cells is a critical first step in the ability to utilize CAR T cells for the treatment of cancer. The 5T4 is a tumor-associated antigen which is expressed on the cell surface of most solid tumors including ovarian cancer...
December 12, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29239906/nerve-growth-factor-changes-and-corneal-nerve-repair-after-keratoplasty
#14
Yueji Pan, Fang Liu, Xiaofeng Qi, Yuan Hu, Feihong Xu, Hui Jia
SIGNIFICANCE: Measured tear concentration of nerve growth factor is correlated with postoperative corneal reinnervation among patients who undergo keratoplasty. This may be a future therapeutic target for post-keratoplasty corneal nerve regeneration. PURPOSE: To determine the relationship between changes in the content of nerve growth factor (NGF) in tear fluid and corneal subepithelial nerve regeneration in patients after keratoplasty. METHODS: In this retrospective study, 30 eyes of 28 patients (15 males, 13 females; mean age 42...
December 13, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29239899/stroke-severity-quantification-by-critical-care-physicians-in-a-mobile-stroke-unit
#15
Maren R Hov, Jo Røislien, Thomas Lindner, Erik Zakariassen, Kristi C G Bache, Volker M Solyga, David Russell, Christian G Lund
BACKGROUND: Cerebral revascularization in acute stroke requires robust diagnostic tools close to symptom onset. The quantitative National Institute of Health Stroke Scale (NIHSS) is widely used in-hospital, whereas shorter and less specific stroke scales are used in the prehospital field. This study explored the accuracy and potential clinical benefit of using NIHSS prehospitally. PATIENTS AND METHODS: Thirteen anesthesiologists trained in prehospital critical care enrolled patients with suspected acute stroke in a mobile stroke unit...
December 12, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29239893/switch-from-tenofovir-disoproxil-fumarate-combination-to-dolutegravir-plus-rilpivirine-improves-parameters-of-bone-health
#16
Grace A Mccomsey, Sergio Lupo, David Parks, Mónica Coronado Poggio, Joseph De Wet, Lesley P Kahl, Kostas Angelis, Brian Wynne, Kati Vandermeulen, Martin Gartland, Michael Cupo, Michael Aboud
OBJECTIVE: Bone mineral density (BMD) loss, a risk factor for osteoporosis, has been attributed to HIV infection and antiretroviral therapy (ART), including regimens containing tenofovir disoproxil fumarate. DESIGN: Study 202094 is an open-label, parallel-group, sub-study of the phase III SWORD-1 and SWORD-2 studies (ClincialTrials.gov identifier, NCT02478632). METHODS: HIV-1-infected adults with HIV-1 RNA < 50 copies per mL who received ART containing tenofovir disoproxil fumarate for ≥6 months were randomized to receive dolutegravir+rilpivirine or continue current ART regimen...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239842/relative-rates-not-relative-risks-addressing-a-widespread-misinterpretation-of-hazard-ratios
#17
Rinku Sutradhar, Peter C Austin
The use of the Cox proportional hazards model is ubiquitous in modern medical research. Despite the widespread implementation of this model, the terminology and interpretation that is used to describe the estimate hazard ratio (HR) has become loose and, unfortunately, often incorrect. Although some journals offer guidelines that advise against reporting HRs as relative risks, these guidelines are frequently overlooked. Perhaps due to a lack of understanding, authors continue to interpret the resultant HR as a relative risk-such an interpretation is inappropriate and can be misleading...
November 7, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29239834/do-residency-selection-factors-predict-radiology-resident-performance
#18
Vikas Agarwal, Gregory M Bump, Matthew T Heller, Ling-Wan Chen, Barton F Branstetter, Nikhil B Amesur, Marion A Hughes
RATIONALE AND OBJECTIVES: The purpose of our study is to determine what information in medical student residency applications predicts radiology residency success as defined by objective clinical performance data. MATERIALS AND METHODS: We performed a retrospective cohort study of residents who entered our institution's residency program through the National Resident Matching Program as postgraduate year 2 residents and completed the program over the past 2 years...
November 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29239253/fifty-top-cited-spine-articles-from-mainland-china-a-citation-analysis
#19
Yaohong Wu, Yachao Zhao, Linghan Lin, Zhijun Lu, Zhaoyang Guo, Xiaoming Li, Rongchun Chen, Huasong Ma
Objective To identify the 50 top-cited spine articles from mainland China and to analyze their main characteristics. Methods Web of Science was used to identify the 50 top-cited spine articles from mainland China in 27 spine-related journals. The title, year of publication, number of citations, journal, anatomic focus, subspecialty, evidence level, city, institution and author were recorded. Results The top 50 articles had 29-122 citations and were published in 11 English-language journals; most (32) were published in the 2000s...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29239150/gender-differences-in-septic-intensive-care-unit-patients
#20
Francesco Campanelli, Giovanni Landoni, Luca Cabrini, Alberto Zangrillo
BACKGROUND: The world population is mostly male at birth, although there is a shift in predominance over 55 years of age with more females than males. Male gender was recently hypothesized to be a risk factor for sepsis and septic shock; the reasons and the consequences of this odd discrepancy are yet a matter of debate. We investigated the percentage of males and females in a large number of trials performed on septic adult patients admitted to Intensive Care Units. METHODS: We analysed all the multicentre randomized controlled trials ever published in peer-reviewed Journals reporting a significant effect on mortality in intensive care unit septic adult patients; furthermore, we retrieved all the manuscripts dealing with sepsis or septic shock patients published in the last 3 years in the three medical Journals with the highest impact factor...
December 13, 2017: Minerva Anestesiologica
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