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https://www.readbyqxmd.com/read/28933747/facilitators-of-physical-activity-voices-of-adolescents-in-a-disadvantaged-community
#1
Linus Jonsson, Christina Berg, Christel Larsson, Peter Korp, Eva-Carin Lindgren
Despite increasing socioeconomic inequalities in the health and well-being of adolescents, the voices of adolescents in disadvantaged communities regarding facilitators of physical activity (PA) have received relatively little attention. In response, the purpose of this study was to illuminate what adolescents in a multicultural community of low socioeconomic status (SES) in Sweden convey concerning facilitators of PA. Adolescents (n = 53, aged 12-13 years) were recruited from a school in a multicultural community of low SES in Sweden...
July 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28930774/high-levels-of-cerebrospinal-fluid-chemokines-point-to-the-presence-of-neuroinflammation-in-peripheral-neuropathic-pain-a-cross-sectional-study-of-two-cohorts-of-patients-compared-to-healthy-controls
#2
Emmanuel Bäckryd, Anne-Li Lind, Måns Thulin, Anders Larsson, Björn Gerdle, Torsten Gordh
Animal models suggest that chemokines are important mediators in the pathophysiology of neuropathic pain. Indeed, these substances have been called "gliotransmitters", a term that illustrates the close interplay between glial cells and neurons in the context of neuroinflammation and pain. However, evidence in humans is scarce. The aim of the study was to determine a comprehensive cerebrospinal fluid (CSF) inflammatory profile for neuropathic pain patients. Our hypothesis was that we would thereby find indications of a postulated on-going process of central neuroinflammation...
September 18, 2017: Pain
https://www.readbyqxmd.com/read/28929972/abstracts-from-hydrocephalus-2016
#3
A Adam, J Robison, J Lu, R Jose, N Badran, T Vivas-Buitrago, D Rigamonti, A Sattar, O Omoush, M Hammad, M Dawood, M Maghaslah, T Belcher, K Carson, J Hoffberger, I Jusué Torres, S Foley, S Yasar, Q A Thai, J Wemmer, P Klinge, L Al-Mutawa, H Al-Ghamdi, K A Carson, M Asgari, D de Zélicourt, V Kurtcuoglu, S Garnotel, S Salmon, O Balédent, A Lokossou, G Page, L Balardy, Z Czosnyka, P Payoux, E A Schmidt, M Zitoun, M A Sevestre, N Alperin, I Baudracco, C Craven, S Matloob, S Thompson, P Haylock Vize, L Thorne, L D Watkins, A K Toma, Karl Bechter, A C Pong, L Jugé, L E Bilston, S Cheng, W Bradley, F Hakim, J F Ramón, M F Cárdenas, J S Davidson, C García, D González, S Bermúdez, N Useche, J A Mejía, P Mayorga, F Cruz, C Martinez, M C Matiz, M Vallejo, K Ghotme, H A Soto, D Riveros, A Buitrago, M Mora, L Murcia, S Bermudez, D Cohen, D Dasgupta, C Curtis, L Domínguez, A J Remolina, M A Grijalba, K J Whitehouse, R J Edwards, A Eleftheriou, F Lundin, K N Fountas, E Z Kapsalaki, H F Smisson, J S Robinson, M J Fritsch, W Arouk, M Garzon, M Kang, K Sandhu, D Baghawatti, K Aquilina, G James, D Thompson, M Gehlen, M Schmid Daners, A Eklund, J Malm, D Gomez, M Guerra, M Jara, M Flores, K Vío, I Moreno, S Rodríguez, E Ortega, E M Rodríguez, J P McAllister, M M Guerra, D M Morales, D Sival, A Jimenez, D D Limbrick, M Ishikawa, S Yamada, K Yamamoto, A Junkkari, A Häyrinen, T Rauramaa, H Sintonen, O Nerg, A M Koivisto, R P Roine, H Viinamäki, H Soininen, A Luikku, J E Jääskeläinen, V Leinonen, U Kehler, O Lilja-Lund, K Kockum, E M Larsson, K Riklund, L Söderström, P Hellström, K Laurell, M Kojoukhova, A Sutela, R Vanninen, K I Vanha, M Timonen, J Rummukainen, V Korhonen, S Helisalmi, E Solje, A M Remes, J Huovinen, J Paananen, M Hiltunen, M Kurki, B Martin, F Loth, M Luciano, A J Luikku, A Hall, S K Herukka, J Mattila, J Lötjönen, I Alafuzoff, I Jurjević, M Miyajima, M Nakajima, H Murai, T Shin, D Kawaguchi, C Akiba, I Ogino, K Karagiozov, H Arai, R C Reis, M J Teixeira, C G Valêncio, D da Vigua, L Almeida-Lopes, M W Mancini, F C G Pinto, R H Maykot, G Calia, J Tornai, S S S Silvestre, G Mendes, V Sousa, B Bezerra, P Dutra, P Modesto, M F Oliveira, C E Petitto, H Pulhorn, A Chandran, C McMahon, A S Rao, M Jumaly, D Solomon, A Moghekar, N Relkin, M Hamilton, H Katzen, M Williams, T Bach, S Zuspan, R Holubkov, A Rigamonti, G Clemens, P Sharkey, A Sanyal, E Sankey, K Rigamonti, S Naqvi, A Hung, E Schmidt, F Ory-Magne, P Gantet, A Guenego, A C Januel, P Tall, N Fabre, L Mahieu, C Cognard, L Gray, J A Buttner-Ennever, K Takagi, K Onouchi, S D Thompson, L D Thorne, H M Tully, T L Wenger, W A Kukull, D Doherty, W B Dobyns, D Moran, S Vakili, M A Patel, B Elder, C R Goodwin, J A Crawford, M V Pletnikov, J Xu, A Blitz, D A Herzka, H Guerrero-Cazares, A Quiñones-Hinojosa, S Mori, P Saavedra, H Treviño, K Maitani, W C Ziai, V Eslami, S Nekoovaght-Tak, R Dlugash, G Yenokyan, N McBee, D F Hanley
No abstract text is available yet for this article.
June 7, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28925402/contrasting-effects-of-an-mdm2-functional-polymorphism-on-tumor-phenotypes
#4
G J Ortiz, Y Li, S M Post, V Pant, S Xiong, C A Larsson, A K El-Naggar, D G Johnson, G Lozano
MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tumor suppressor and is elevated in many human cancers that retain wild-type p53. MDM2 SNP309G is a functional polymorphism that results in elevated levels of MDM2 (due to enhanced SP1 binding to the MDM2 promoter) thus decreasing p53 activity. Mdm2(SNP309G/G) mice are more prone to spontaneous tumor formation than Mdm2(SNP309T/T) mice, providing direct evidence for the impact of this SNP in tumor development. We asked whether environmental factors impact SNP309G function and show that SNP309G cooperates with ionizing radiation to exacerbate tumor development...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28924044/nuclear-insulin-like-growth-factor-1-receptor-phosphorylates-proliferating-cell-nuclear-antigen-and-rescues-stalled-replication-forks-after-dna-damage
#5
Ahmed Waraky, Yingbo Lin, Dudi Warsito, Felix Haglund, Eiman Aleem, Olle Larsson
We have previously shown that the insulin like growth factor 1 receptor (IGF1R) translocates to the cell nucleus, where it binds to enhancer like regions and increases gene transcription. Further studies have demonstrated that nuclear IGF1R (nIGF1R) physically and functionally interacts with some nuclear proteins, i.e. the lymphoid enhancer binding factor 1 (Lef1), histone H3, and Brahma related gene 1 proteins. In the present study, we identified the proliferating cell nuclear antigen (PCNA) as a nIGF1R binding partner...
September 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28923975/control-of-actin-polymerization-via-the-coincidence-of-phosphoinositides-and-high-membrane-curvature
#6
Frederic Daste, Astrid Walrant, Mikkel R Holst, Jonathan R Gadsby, Julia Mason, Ji-Eun Lee, Daniel Brook, Marcel Mettlen, Elin Larsson, Steven F Lee, Richard Lundmark, Jennifer L Gallop
The conditional use of actin during clathrin-mediated endocytosis in mammalian cells suggests that the cell controls whether and how actin is used. Using a combination of biochemical reconstitution and mammalian cell culture, we elucidate a mechanism by which the coincidence of PI(4,5)P2 and PI(3)P in a curved vesicle triggers actin polymerization. At clathrin-coated pits, PI(3)P is produced by the INPP4A hydrolysis of PI(3,4)P2, and this is necessary for actin-driven endocytosis. Both Cdc42⋅guanosine triphosphate and SNX9 activate N-WASP-WIP- and Arp2/3-mediated actin nucleation...
September 18, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28922571/interprofessional-oral-health-initiative-in-a-nondental-american-indian-setting
#7
Kate L Murphy, Laura S Larsson
BACKGROUND AND PURPOSE: Tooth decay is the most common chronic childhood disease and American Indian (AI) children are at increased risk. Pediatric primary care providers are in an opportune position to reduce tooth decay. The purpose of this study was to integrate and evaluate a pediatric oral health project in an AI, pediatric primary care setting. METHODS: The intervention set included caregiver education, caries risk assessment, and a same-day dental home referral...
September 18, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28919990/pharmacological-targeting-of-peptidylarginine-deiminase-4-prevents-cancer-associated-kidney-injury-in-mice
#8
Jessica Cedervall, Anca Dragomir, Falk Saupe, Yanyu Zhang, Johan Ärnlöv, Erik Larsson, Anna Dimberg, Anders Larsson, Anna-Karin Olsson
Renal insufficiency is a frequent cancer-associated problem affecting more than half of all cancer patients at the time of diagnosis. To minimize nephrotoxic effects the dosage of anticancer drugs are reduced in these patients, leading to sub-optimal treatment efficacy. Despite the severity of this cancer-associated pathology, the molecular mechanisms, as well as therapeutic options, are still largely lacking. We here show that formation of intravascular tumor-induced neutrophil extracellular traps (NETs) is a cause of kidney injury in tumor-bearing mice...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28919840/leptin-independently-predicts-development-of-sepsis-and-its-outcome
#9
Sofie Jacobsson, Peter Larsson, Göran Johansson, Margareta Norberg, Göran Wadell, Göran Hallmans, Ola Winsö, Stefan Söderberg
BACKGROUND: Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved. METHODS: Patients aged 18 years or more with documented first time sepsis events were included in a nested case-referent study if they had participated in previous health surveys. Two matched referents free of known sepsis were identified...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/28918902/mtor-controls-mitochondrial-dynamics-and-cell-survival-via-mtfp1
#10
Masahiro Morita, Julien Prudent, Kaustuv Basu, Vanessa Goyon, Sakie Katsumura, Laura Hulea, Dana Pearl, Nadeem Siddiqui, Stefan Strack, Shawn McGuirk, Julie St-Pierre, Ola Larsson, Ivan Topisirovic, Hojatollah Vali, Heidi M McBride, John J Bergeron, Nahum Sonenberg
The mechanisms that link environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well understood. Here, we demonstrate that the nutrient-sensing mechanistic/mammalian target of rapamycin complex 1 (mTORC1) stimulates translation of mitochondrial fission process 1 (MTFP1) to control mitochondrial fission and apoptosis. Expression of MTFP1 is coupled to pro-fission phosphorylation and mitochondrial recruitment of the fission GTPase dynamin-related protein 1 (DRP1)...
September 13, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28916826/in-vitro-and-in-vivo-biocompatibility-evaluation-of-polyallylamine-and-macromolecular-heparin-conjugates-modified-alginate-microbeads
#11
Vijayaganapathy Vaithilingam, Bjørg Steinkjer, Liv Ryan, Rolf Larsson, Bernard Edward Tuch, Jose Oberholzer, Anne Mari Rokstad
Host reactivity to biocompatible immunoisolation devices is a major challenge for cellular therapies, and a human screening model would be of great value. We designed new types of surface modified barium alginate microspheres, and evaluated their inflammatory properties using human whole blood, and the intraperitoneal response after three weeks in Wistar rats. Microspheres were modified using proprietary polyallylamine (PAV) and coupled with macromolecular heparin conjugates (Corline Heparin Conjugate, CHC)...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916567/perspective-an-extension-of-the-strobe-statement-for-observational-studies-in-nutritional-epidemiology-strobe-nut-explanation-and-elaboration
#12
Agneta Hörnell, Christina Berg, Elisabet Forsum, Christel Larsson, Emily Sonestedt, Agneta Åkesson, Carl Lachat, Dana Hawwash, Patrick Kolsteren, Graham Byrnes, Willem De Keyzer, John Van Camp, Janet E Cade, Darren C Greenwood, Nadia Slimani, Myriam Cevallos, Matthias Egger, Inge Huybrechts, Elisabet Wirfält
Nutritional epidemiology is an inherently complex and multifaceted research area. Dietary intake is a complex exposure and is challenging to describe and assess, and links between diet, health, and disease are difficult to ascertain. Consequently, adequate reporting is necessary to facilitate comprehension, interpretation, and generalizability of results and conclusions. The STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement is an international and collaborative initiative aiming to enhance the quality of reporting of observational studies...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28915122/understanding-fetal-factors-that-contribute-to-preterm-birth-sj%C3%A3-gren-larsson-syndrome-as-a-model
#13
Pippa Staps, Marije Hogeveen, Joris Fuijkschot, Joris van Drongelen, Michèl A A P Willemsen
AIM: Preterm birth is the world's leading cause of neonatal death. Unfortunately, the pathophysiology of preterm birth remains poorly understood. Sjögren-Larsson syndrome is a rare, neurometabolic disorder caused by a fatty aldehyde dehydrogenase deficiency. A majority of patients with Sjögren-Larsson syndrome is born preterm. METHODS: Data of all known Dutch patients with Sjögren-Larsson syndrome and all cases reported in literature were analyzed to learn from preterm birth in context of this rare disease...
September 15, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28914981/fna-cytology-of-solitary-fibrous-tumors-and-the-diagnostic-value-of-stat6-immunocytochemistry
#14
Edneia Tani, Johan Wejde, Kristina Åström, Inga-Lill Wingmo, Olle Larsson, Felix Haglund
BACKGROUND: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene. Recent studies have indicated that nuclear STAT6 immunohistochemistry is a specific marker for SFTs. METHODS: The authors reviewed fine-needle aspiration (FNA) specimens from extracranial SFTs diagnosed at their institution between 1993 and 2017...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28910541/seasonal-variability-of-nt-probnp-in-swedish-primary-care-patients
#15
Banafsheh Seyyed Khezri, Maria Cederblad, Johanna Helmersson-Karlqvist, Bo Karlsson, Håkan Melhus, Anders Larsson
The aim of this study was to determine if there is a seasonal variation in the widely used heart failure marker NT-proBNP. The study included all primary care requests for NT-proBNP in the county of Uppsala, Sweden, between January 2007 and December 2015. For seasonal variation, the NT-proBNP results for individual months were compared. The NT-proBNP values were highest in July to September, but there was also a minor peak in December-January. In conclusion, a seasonal periodicity for NT-proBNP was demonstrated in primary care patients...
September 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28902669/alpps-improves-resectability-compared-with-conventional-two-stage-hepatectomy-in-patients-with-advanced-colorectal-liver-metastasis-results-from-a-scandinavian-multicenter-randomized-controlled-trial-ligro-trial
#16
Per Sandström, Bård I Røsok, Ernesto Sparrelid, Peter N Larsen, Anna L Larsson, Gert Lindell, Nicolai A Schultz, Bjorn A Bjørnbeth, Bengt Isaksson, Magnus Rizell, Bergthor Björnsson
OBJECTIVE: The aim of the study was to evaluate if associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could increase resection rates (RRs) compared with two-stage hepatectomy (TSH) in a randomized controlled trial (RCT). BACKGROUND: Radical liver metastasis resection offers the only chance of a cure for patients with metastatic colorectal cancer. Patients with colorectal liver metastasis (CRLM) and an insufficient future liver remnant (FLR) volume are traditionally treated with chemotherapy with portal vein embolization or ligation followed by hepatectomy (TSH)...
September 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28901333/a-paleolithic-type-diet-results-in-iodine-deficiency-a-2-year-randomized-trial-in-postmenopausal-obese-women
#17
S Manousou, M Stål, C Larsson, C Mellberg, B Lindahl, R Eggertsen, L Hulthén, T Olsson, M Ryberg, S Sandberg, H F Nyström
BACKGROUND/OBJECTIVES: Different diets are used for weight loss. A Paleolithic-type diet (PD) has beneficial metabolic effects, but two of the largest iodine sources, table salt and dairy products, are excluded. The objectives of this study were to compare 24-h urinary iodine concentration (24-UIC) in subjects on PD with 24-UIC in subjects on a diet according to the Nordic Nutrition Recommendations (NNR) and to study if PD results in a higher risk of developing iodine deficiency (ID), than NNR diet...
September 13, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28899757/segmentation-of-the-inferior-longitudinal-fasciculus-in-the-human-brain-a-white-matter-dissection-and-diffusion-tensor-tractography-study
#18
Francesco Latini, Johanna Mårtensson, Elna-Marie Larsson, Mats Fredrikson, Fredrik Åhs, Mats Hjortberg, Håkan Aldskogius, Mats Ryttlefors
The inferior longitudinal fascicle (ILF) is one of the major occipital-temporal association pathways. Several studies have mapped its hierarchical segmentation to specific functions. There is, however, no consensus regarding a detailed description of ILF fibre organisation. The aim of this study was to establish whether the ILF has a constant number of subcomponents. A secondary aim was to determine the quantitative diffusion proprieties of each subcomponent and assess their anatomical trajectories and connectivity patterns...
September 9, 2017: Brain Research
https://www.readbyqxmd.com/read/28899606/is-tissue-engineering-of-patient-specific-oral-mucosa-grafts-the-future-of-urethral-reconstruction
#19
Hans M Larsson
No abstract text is available yet for this article.
September 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28895530/cell-type-boundaries-organize-plant-development
#20
Monica Pia Caggiano, Xiulian Yu, Neha Bhatia, Andre Larsson, Hasthi Ram, Carolyn K Ohno, Pia Sappl, Elliot M Meyerowitz, Henrik Jönsson, Marcus G Heisler
In plants the dorsoventral boundary of leaves defines an axis of symmetry through the centre of the organ separating the top (dorsal) and bottom (ventral) tissues. Although the positioning of this boundary is critical for leaf morphogenesis, how the boundary is established and how it influences development remains unclear. Using live-imaging and perturbation experiments we show that leaf orientation, morphology and position are pre-patterned by HD-ZIPIII and KAN gene expression in the shoot, leading to a model in which dorsoventral genes coordinate to regulate plant development by localizing auxin response between their expression domains...
September 12, 2017: ELife
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