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https://www.readbyqxmd.com/read/28343067/reading-problems-and-major-mental-disorders-co-occurrences-and-familial-overlaps-in-a-swedish-nationwide-cohort
#1
Martin Cederlöf, Barbara Maughan, Henrik Larsson, Brian M D'Onofrio, Robert Plomin
Reading problems often co-occur with ADHD and conduct disorder. However, the patterns of co-occurrence and familial overlap between reading problems and other psychiatric disorders have not been systematically explored. We conducted a register-based cohort study including 8719 individuals with reading problems and their siblings, along with matched comparison individuals. Conditional logistic regressions estimated risks for ADHD, autism, obsessive-compulsive disorder, anorexia nervosa, schizophrenia, bipolar disorder, depression, substance use disorder, and violent/non-violent criminality in individuals with reading problems and their siblings...
March 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28340215/development-of-enzyme-immunoassays-elisa-and-western-blot-for-the-serological-diagnosis-of-dermatophytosis-in-symptomatic-and-asymptomatic-cats
#2
Aline Elisa Santana, Carlos Pelleschi Taborda, Julia So Severo, Glauce Mary Gomes Rittner, Julian Esteban Muñoz, Carlos Eduardo Larsson, Carlos Eduardo Larsson
Dermatophytosis is the most common fungal infection in cats worldwide and plays an important role in both animal and human health due to their high zoonotic potential. Effective screening is a strong preventive measure and the fungal culture is quite useful but requires full laboratorial experience and it takes a long time to obtain the result. A rapid and accurate screening test for dermatophytosis in cats is crucial for the effective control of disease outbreaks. The aim of this study was to develop and evaluate the diagnostic efficacy of enzyme immunoassays (ELISA and Western blot [WB]) for the rapid and precise diagnosis of dermatophytosis in cats...
March 11, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28338765/cerebral-magnesium-levels-in-preeclampsia-a-phosphorus-magnetic-resonance-spectroscopy-study
#3
Maria Nelander, Jan Weis, Lina Bergman, Anders Larsson, Anna-Karin Wikström, Johan Wikström
BACKGROUND: Magnesium sulfate (MgSO4) is used as a prophylaxis for eclamptic seizures. The exact mechanism of action is not fully established. We used phosphorus magnetic resonance spectroscopy (31P-MRS) to investigate if cerebral magnesium (Mg2+) levels differ between women with preeclampsia, normal pregnant, and nonpregnant women. METHODS: This cross-sectional study comprised 28 women with preeclampsia, 30 women with normal pregnancies in corresponding gestational week (range: 23-41 weeks) and 11 nonpregnant healthy controls...
February 21, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28334095/phantom-smells-prevalence-and-correlates-in-a-population-based-sample-of-older-adults
#4
Sara Sjölund, Maria Larsson, Jonas K Olofsson, Janina Seubert, Erika J Laukka
Loss of olfactory function is common in old age, but evidence regarding qualitative olfactory dysfunction in the general older population is scarce. The current study investigates the prevalence and correlates of phantom smell experiences (phantosmia) in a population-based study (Swedish National Study on Aging and Care in Kungsholmen [SNAC-K]) of Swedish adults (n = 2569) aged between 60 and 90 years. Phantosmia was assessed through a standardized interview and defined as reporting having experienced an odor percept in the absence of any stimuli in the surrounding environment that could emit the odor...
February 20, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28332282/chirally-sensitive-collision-induced-dissociation-of-proton-bound-diastereomeric-complexes-of-tryptophan-and-2-butanol
#5
Oleksii Rebrov, Kostiantyn Kulyk, Mauritz Ryding, Richard D Thomas, Einar Uggerud, Mats Larsson
In this work we report the stereo-dependent collision-induced dissociation (CID) of proton-bound complexes of tryptophan and 2-butanol. The dissociation efficiency was measured as a function of collision energy in single collision mode. The homochiral complex was found to be less stable against CID than a heterochiral one. Additional gas dependence measurements were performed with diastereomeric complexes that confirm the findings.
March 23, 2017: Chirality
https://www.readbyqxmd.com/read/28332025/endurance-aerobic-high-intensity-and-repeated-sprint-cycling-performance-is-unaffected-by-normobaric-live-high-train-low-a-double-blind-placebo-controlled-cross-over-study
#6
Jacob Bejder, Andreas Breenfeldt Andersen, Rie Buchardt, Tanja Hultengren Larsson, Niels Vidiendal Olsen, Nikolai Baastrup Nordsborg
The aim was to investigate whether 6 weeks of normobaric "Live High-Train Low" (LHTL) using altitude tents affect highly trained athletes incremental peak power, 26-km time-trial cycling performance, 3-min all-out performance, and 30-s repeated sprint ability. In a double-blinded, placebo-controlled cross-over design, seven highly trained triathletes were exposed to 6 weeks of normobaric hypoxia (LHTL) and normoxia (placebo) for 8 h/day. LHTL exposure consisted of 2 weeks at 2500 m, 2 weeks at 3000 m, and 2 weeks at 3500 m...
March 22, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28328323/an-adaptable-high-throughput-technology-enabling-the-identification-of-specific-transcription-modulators
#7
Tim Bergbrede, Emily Hoberg, Nils-Göran Larsson, Maria Falkenberg, Claes M Gustafsson
Mitochondria harbor the oxidative phosphorylation (OXPHOS) system, which under aerobic conditions produces the bulk of cellular adenosine triphosphate (ATP). The mitochondrial genome encodes key components of the OXPHOS system, and it is transcribed by the mitochondrial RNA polymerase, POLRMT. The levels of mitochondrial transcription correlate with the respiratory activity of the cell. Therefore, compounds that can increase or decrease mitochondrial gene transcription may be useful for fine-tuning metabolism and could be used to treat metabolic diseases or certain forms of cancer...
April 2017: SLAS Discov
https://www.readbyqxmd.com/read/28327077/regional-muscle-tissue-saturation-is-an-indicator-of-global-inadequate-circulation-during-cardiopulmonary-bypass-a-randomized-porcine-study-using-muscle-intestinal-and-brain-tissue-metabolomics
#8
Sisse Anette Thomassen, Benedict Kjærgaard, Preben Sørensen, Jan Jesper Andreasen, Anders Larsson, Bodil Steen Rasmussen
BACKGROUND: Muscle tissue saturation (StO2) measured with near-infrared spectroscopy has generally been considered a measurement of the tissue microcirculatory condition. However, we hypothesized that StO2 could be more regarded as a fast and reliable measure of global than of regional circulatory adequacy and tested this with muscle, intestinal and brain metabolomics at normal and two levels of low cardiopulmonary bypass blood flow rates in a porcine model. METHODS: Twelve 80 kg pigs were connected to normothermic cardiopulmonary bypass with a blood flow of 60 mL/kg/min for one hour, reduced randomly to 47...
April 2017: Perfusion
https://www.readbyqxmd.com/read/28326534/smell-loss-predicts-mortality-risk-regardless-of-dementia-conversion
#9
Ingrid Ekström, Sara Sjölund, Steven Nordin, Annelie Nordin Adolfsson, Rolf Adolfsson, Lars-Göran Nilsson, Maria Larsson, Jonas K Olofsson
OBJECTIVES: To determine whether dementia could explain the association between poor olfactory performance and mortality risk within a decade-long follow-up period. DESIGN: Prospective cohort study. SETTING: Betula Study, Umeå, Sweden. PARTICIPANTS: A population-based sample of adult participants without dementia at baseline aged 40 to 90 (N = 1,774). MEASUREMENTS: Olfactory performance using the Scandinavian Odor-Identification Test (SOIT) and self-reported olfactory function; several social, cognitive, and medical risk factors at baseline; and incident dementia during the following decade...
March 22, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28326179/clinic-continuity-of-care-clinical-outcomes-and-direct-costs-for-copd-in-sweden-a-population-based-cohort-study
#10
Sofia Sveréus, Kjell Larsson, Clas Rehnberg
Introduction: In this study we investigate whether clinic level continuity of care (COC) for individuals with chronic obstructive pulmonary disease (COPD) is associated with better health care outcomes and lower costs in a Swedish setting. Methods: Individuals with COPD (N = 20,187) were identified through ICD-10 codes in all Stockholm County health care registries in 2007-2011 (59% female, 40% in the age group 65-74 years). We followed the individuals prospectively for 365 days after their first outpatient visit in 2012...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28326177/characterization-of-secondary-care-for-copd-in-sweden
#11
Josefin Sundh, Christer Janson, Gunnar Johansson, Anders Lindén, Claes-Göran Löfdahl, Thomas Sandström, Kjell Larsson
Introduction: Only a selected proportion of chronic obstructive pulmonary disease (COPD) patients are managed in secondary care. The aim of this study was to characterize disease severity, treatment and structure of secondary care for COPD in Sweden. Methods: Information was collected from 29 of 33 existing secondary care units of respiratory medicine in Sweden, using both individual data from 373 consecutively enrolled COPD patients with Global initiative on Obstructive Lung Disease (GOLD) stage III-IV and a structural questionnaire about available resources at the units...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28323144/tissue-expression-and-source-of-circulating-%C3%AE-klotho
#12
REVIEW
Hannes Olauson, Rik Mencke, Jan-Luuk Hillebrands, Tobias E Larsson
αKlotho (Klotho), a type I transmembrane protein and a coreceptor for Fibroblast growth factor-23, was initially thought to be expressed only in a limited number of tissues, most importantly the kidney, parathyroid gland and choroid plexus. Emerging data may suggest a more ubiquitous Klotho expression pattern which has prompted reevaluation of the restricted Klotho paradigm. Herein we systematically review the evidence for Klotho expression in various tissues and cell types in humans and other mammals, and discuss potential reasons behind existing conflicting data...
March 17, 2017: Bone
https://www.readbyqxmd.com/read/28306280/search-for-cosmic-ray-electron-and-positron-anisotropies-with-seven-years-of-fermi-large-area-telescope-data
#13
S Abdollahi, M Ackermann, M Ajello, A Albert, W B Atwood, L Baldini, G Barbiellini, R Bellazzini, E Bissaldi, E D Bloom, R Bonino, E Bottacini, T J Brandt, P Bruel, S Buson, M Caragiulo, E Cavazzuti, A Chekhtman, S Ciprini, F Costanza, A Cuoco, S Cutini, F D'Ammando, F de Palma, R Desiante, S W Digel, N Di Lalla, M Di Mauro, L Di Venere, B Donaggio, P S Drell, C Favuzzi, W B Focke, Y Fukazawa, S Funk, P Fusco, F Gargano, D Gasparrini, N Giglietto, F Giordano, M Giroletti, D Green, S Guiriec, A K Harding, T Jogler, G Jóhannesson, T Kamae, M Kuss, S Larsson, L Latronico, J Li, F Longo, F Loparco, P Lubrano, J D Magill, D Malyshev, A Manfreda, M N Mazziotta, M Meehan, P F Michelson, W Mitthumsiri, T Mizuno, A A Moiseev, M E Monzani, A Morselli, M Negro, E Nuss, T Ohsugi, N Omodei, D Paneque, J S Perkins, M Pesce-Rollins, F Piron, G Pivato, G Principe, S Rainò, R Rando, M Razzano, A Reimer, O Reimer, C Sgrò, D Simone, E J Siskind, F Spada, G Spandre, P Spinelli, A W Strong, H Tajima, J B Thayer, D F Torres, E Troja, J Vandenbroucke, G Zaharijas, S Zimmer
The Large Area Telescope on board the Fermi Gamma-ray Space Telescope has collected the largest ever sample of high-energy cosmic-ray electron and positron events since the beginning of its operation. Potential anisotropies in the arrival directions of cosmic-ray electrons or positrons could be a signature of the presence of nearby sources. We use almost seven years of data with energies above 42 GeV processed with the Pass 8 reconstruction. The present data sample can probe dipole anisotropies down to a level of 10^{-3}...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28302784/draft-genome-sequence-of-francisella-noatunensis-subsp-orientalis-stir-gus-f2f7-a-highly-virulent-strain-recovered-from-diseased-red-nile-tilapia-farmed-in-europe
#14
José Gustavo Ramírez-Paredes, Pär Larsson, Stefanie Wehner, Michaël Bekaert, Caroline Öhrman, Matthijs Metselaar, Kimberly Dawn Thompson, Randolph Harvey Richards, David James Penman, Alexandra Adams
A highly virulent strain of Francisella noatunensis subsp. orientalis, STIR-GUS-F2f7, was isolated from moribund red Nile tilapia (Oreochromis niloticus) farmed in Europe. In this communication, the complete genome sequencing of this bacterium is reported.
March 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28301413/ophthalmic-findings-in-late-stage-sjogren-larsson-syndrome
#15
Tavish Nanda, Jaclyn L Kovach
PURPOSE: To report spectral domain optical coherence tomography and fundus autofluorescence documentation of late stage macular findings associated with Sjogren-Larsson Syndrome in three adult siblings. METHODS: Three adult siblings with Sjogren-Larsson Syndrome underwent ophthalmic examination and imaging. RESULTS: Crystalline maculopathy and subretinal deposits, presumably lipofuscin accumulation, with macular atrophy were present in varying degrees in all three adult siblings...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28291697/early-prehospital-assessment-of-non-urgent-patients-and-outcomes-at-the-appropriate-level-of-care-a-prospective-exploratory-study
#16
Glenn Larsson, Anders Holmén, Kristina Ziegert
INTRODUCTION: The Ambulance Organization of Sweden provides qualified medical assessment and treatment by ambulance nurses based on patient needs regarding appropriate levels of care. A new model for patients with non-urgent medical conditions has been introduced. The main objective of this study was to examine early prehospital assessment of non-urgent patients, and its impact on the choice of the appropriate level of care. METHODS: The study design was a 1-year, prospective study, involving an ambulance district in southwestern Sweden with a population of 78,000...
March 10, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28288611/benefits-of-resistance-exercise-in-lean-women-with-fibromyalgia-involvement-of-igf-1-and-leptin
#17
Jan L Bjersing, Anette Larsson, Annie Palstam, Malin Ernberg, Indre Bileviciute-Ljungar, Monika Löfgren, Björn Gerdle, Eva Kosek, Kaisa Mannerkorpi
BACKGROUND: Chronic pain and fatigue improves by exercise in fibromyalgia (FM) but underlying mechanisms are not known. Obesity is increased among FM patients and associates with higher levels of pain. Symptom improvement after aerobic exercise is affected by body mass index (BMI) in FM. Metabolic factors such as insulin-like growth factor 1 (IGF-1) and leptin may be involved. In this study, the aim was to evaluate the role of metabolic factors in lean, overweight and obese women during resistance exercise, in relation to symptom severity and muscle strength in women with FM...
March 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28286665/parents-experiences-of-discharge-readiness-from-a-swedish-neonatal-intensive-care-unit
#18
Christina Larsson, Ulrika Wågström, Erik Normann, Ylva Thernström Blomqvist
AIM: The aim of this study was to describe how parents experienced the support at, and preparation for discharge from, the NICU and how they experienced the first time at home. DESIGN: A qualitative design with quantitative elements was applied. METHODS: A questionnaire study. Data were analysed using qualitative content analysis with quantitative elements. RESULTS: The majority of included parents felt adequately prepared for going home and sufficiently supported during the first period home...
April 2017: Nursing Open
https://www.readbyqxmd.com/read/28284638/does-antifouling-paint-select-for-antibiotic-resistance
#19
Carl-Fredrik Flach, Chandan Pal, Carl Johan Svensson, Erik Kristiansson, Marcus Östman, Johan Bengtsson-Palme, Mats Tysklind, D G Joakim Larsson
There is concern that heavy metals and biocides contribute to the development of antibiotic resistance via co-selection. Most antifouling paints contain high amounts of such substances, which risks turning painted ship hulls into highly mobile refuges and breeding grounds for antibiotic-resistant bacteria. The objectives of this study were to start investigate if heavy-metal based antifouling paints can pose a risk for co-selection of antibiotic-resistant bacteria and, if so, identify the underlying genetic basis...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28283767/seasonal-variations-of-urate-in-a-swedish-adult-population
#20
Axel Åkerblom, Johanna Helmersson-Karlqvist, Tomas Weitoft, Anders Larsson
Seasonality in the incidence and prevalence of gout has previously been reported but the cause of this seasonality in gout is not explained. The aim of this study was to evaluate possible seasonal variations of urate in a large unselected Swedish adult population. We analyzed 170,915 urate test results from patients at a tertiary care hospital between 2000 and 2016. The results were divided according to sex and sampling month of the year. The median urate values were overall higher in males compared to females and both males and females had peak urate concentrations in the summer months (June-August)...
March 10, 2017: Clinical Rheumatology
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