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https://www.readbyqxmd.com/read/28447477/simultaneous-visualization-of-hydrogen-peroxide-and-water-concentrations-using-photofragmentation-laser-induced-fluorescence
#1
Kajsa Larsson, Marcus Aldén, Joakim Bood
A concept based on photofragmentation laser-induced fluorescence (PFLIF) is for the first time demonstrated for simultaneous detection of hydrogen peroxide (H2O2) and water (H2O) vapor in various mixtures containing the two constituents in a bath of argon gas. A photolysis laser pulse at 248 nm dissociates H2O2 into OH fragments, whereupon a probe pulse, delayed 100 ns and tuned to an absorption line in the A(2)Σ(+) (v = 1) ← X(2)Π(v = 0) band of OH near 282 nm, induces fluorescence. The total OH fluorescence reflects the H2O2 concentration, while its spectral shape is utilized to determine the H2O concentration via a model predicting the ratio between the fluorescence intensities of the A(2)Σ(+) (v = 1) → X(2)Π(v = 1) and the A(2)Σ(+) (v = 0) → X(2)Π(v = 0) bands...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28446496/mobile-based-intervention-intended-to-stop-obesity-in-preschool-aged-children-the-ministop-randomized-controlled-trial
#2
Christine Delisle Nyström, Sven Sandin, Pontus Henriksson, Hanna Henriksson, Ylva Trolle-Lagerros, Christel Larsson, Ralph Maddison, Francisco B Ortega, Jeremy Pomeroy, Jonatan R Ruiz, Kristin Silfvernagel, Toomas Timpka, Marie Löf
Background: Traditional obesity prevention programs are time- and cost-intensive. Mobile phone technology has been successful in changing behaviors and managing weight; however, to our knowledge, its potential in young children has yet to be examined.Objective: We assessed the effectiveness of a mobile health (mHealth) obesity prevention program on body fat, dietary habits, and physical activity in healthy Swedish children aged 4.5 y.Design: From 2014 to 2015, 315 children were randomly assigned to an intervention or control group...
April 26, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28444135/prevalence-and-correlates-of-olfactory-dysfunction-in-old-age-a-population-based-study
#3
Janina Seubert, Erika J Laukka, Debora Rizzuto, Thomas Hummel, Laura Fratiglioni, Lars Bäckman, Maria Larsson
Background: Olfactory dysfunction (OD) in old age is associated with poor health outcomes. Interrelationships among different correlates of OD can offer insights into the underlying mechanisms, but to date remain understudied. Methods: Odor identification performance and self-reported olfactory functioning were studied in 2,234 people aged 60-90 years, who were free of neurodegenerative disease and enrolled in the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) study, Stockholm, Sweden...
April 21, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28440851/resurssl%C3%A3-seri-motverkar-individanpassad-kol-behandling
#4
Kjell Larsson
No abstract text is available yet for this article.
April 20, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28440846/viktminskning-utan-kirurgi-kr%C3%A3-ver-energirestriktion-och-f%C3%A3-ljsamhet-ger-minskat-nyinsjuknande-i-diabetes-och-f%C3%A3-rb%C3%A3-ttrade-kardiovaskul%C3%A3-ra-riskfaktorer-visar-litteraturgenomg%C3%A3-ng
#5
Ingrid Larsson, Madeléne Sandqvist, Malin Werling, Malin Wiklund, Christina Bergh, Björn Eliasson
Energy restriction and adherence required for weight loss without surgery Non-surgical weight loss treatment has not been shown to reduce mortality or cardiovascular morbidity, but can prevent diabetes mellitus and improves cardiovascular risk factors. For weight loss, energy restriction is fundamental and can lead to an average 2 to 20 kg loss over 6 to 12 months. Pharmacological treatment, behaviour therapy, physical activity and weight loss advice through web sites and smartphone applications and combinations in addition to energy restriction can contribute to further, but relatively limited weight loss up to 30 months...
April 25, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28440046/attenuated-low-grade-inflammation-following-long-term-dietary-intervention-in-postmenopausal-women-with-obesity
#6
Caroline Blomquist, Malin Alvehus, Jonas Burén, Mats Ryberg, Christel Larsson, Bernt Lindahl, Caroline Mellberg, Ingegerd Söderström, Elin Chorell, Tommy Olsson
OBJECTIVE: Abdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed. METHODS: Seventy healthy postmenopausal women (age 60 ± 5.6 years) with BMI 32.5 ± 5.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters...
May 2017: Obesity
https://www.readbyqxmd.com/read/28438377/efficacy-and-safety-of-lactobacillus-plantarum-dsm-9843-lp299v-in-the-prevention-of-antibiotic-associated-gastrointestinal-symptoms-in-children-randomized-double-blind-placebo-controlled-study
#7
Agnieszka Olek, Marek Woynarowski, Irini Lazou Ahrén, Jarosław Kierkuś, Piotr Socha, Niklas Larsson, Gunilla Önning
OBJECTIVES: To determine if Lactobacillus plantarum DSM9843 (LP299V) reduces the frequency of antibiotic-associated loose/watery stools and gastrointestinal symptoms, and can be administered safely to children who are prescribed antibiotics. STUDY DESIGN: We performed a prospective, double-blind, randomized, placebo-controlled, multicenter, parallel-group study in children receiving outpatient antibiotic therapy in primary healthcare settings. The children were given LP299V/placebo during the antibiotic therapy and for 1 week after the end of treatment...
April 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28436406/questionnaire-based-evaluation-of-mobile-phone-interference-with-medical-electrical-equipment-in-swedish-hospitals
#8
Stig Wiinberg, Göran Samuelsson, Stefan Larsson, Barbro Nilsson, Patrik X Jönsson, Bodil Ivarsson, Per-Åke Olofsson
National recommendations in Sweden recommend a safety distance of 3 m between mobile phones and medical-electrical (ME) equipment in hospitals. A questionnaire was used to investigate how often mobile phones were reported to interfere with ME products in clinical practice across Sweden. The results confirmed that ME equipment can be affected by mobile phone use but, the risk of the patient's outcome being affected were minimal; no cases were identified which led to injury or death. In conclusion, the results support recommendations for a general safety distance of 0...
April 14, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28436115/genetic-and-environmental-contributions-to-the-association-between-adhd-and-affective-problems-in-early-childhood-a-swedish-population-based-twin-study
#9
Mina Rydell, Mark J Taylor, Henrik Larsson
Few twin studies have explored the relative contribution of genetic and environmental factors to the association between attention deficit hyperactivity disorder (ADHD) and affective problems, and no study has focused on preschool children. We used the classical twin design to explore the genetic and environmental overlap between ADHD symptoms and affective problems in preschool children, based on 879 five-year-old twin pairs born in Sweden 2004-2005. Questionnaire-based parent-ratings were used to measure ADHD symptoms and affective problems...
April 24, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28430860/increased-brainstem-perfusion-but-no-blood-brain-barrier-disruption-during-attacks-of-migraine-with-aura
#10
Anders Hougaard, Faisal M Amin, Casper E Christensen, Samaira Younis, Frauke Wolfram, Stig P Cramer, Henrik B W Larsson, Messoud Ashina
The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache...
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28426755/correction-limbic-thalamo-cortical-projections-and-reward-related-circuitry-integrity-affects-eating-behavior-a-longitudinal-dti-study-in-adolescents-with-restrictive-eating-disorders
#11
Gaia Olivo, Lyle Wiemerslage, Ingemar Swenne, Christina Zhukovsky, Helena Salonen-Ros, Elna-Marie Larsson, Santino Gaudio, Samantha J Brooks, Helgi B Schiöth
[This corrects the article DOI: 10.1371/journal.pone.0172129.].
2017: PloS One
https://www.readbyqxmd.com/read/28424559/evidence-of-both-systemic-inflammation-and-neuroinflammation-in-fibromyalgia-patients-as-assessed-by-a-multiplex-protein-panel-applied-to-the-cerebrospinal-fluid-and-to-plasma
#12
Emmanuel Bäckryd, Lars Tanum, Anne-Li Lind, Anders Larsson, Torsten Gordh
In addition to central hyperexcitability and impaired top-down modulation, chronic inflammation probably plays a role in the pathophysiology of fibromyalgia (FM). Indeed, on the basis of both animal experiments and human studies involving the analysis of cytokines and other inflammation-related proteins in different body fluids, neuroinflammatory mechanisms are considered to be central to the pathophysiology of many chronic pain conditions. However, concerning FM, previous human plasma/serum and/or cerebrospinal fluid (CSF) cytokine studies have looked only at a few predetermined cytokine candidates...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28419156/school-nurses-attitudes-towards-and-experiences-of-the-swedish-school-based-hpv-vaccination-programme-a-repeated-cross-sectional-study
#13
Maria Grandahl, Margareta Larsson, Tanja Tydén, Christina Stenhammar
The aim was to investigate school nurses' attitudes towards, and experiences of vaccination against human papillomavirus (HPV), and compare the results with a similar study three years earlier. School nurses (n = 736) from all counties in Sweden completed a questionnaire in spring 2016, four years after the implementation of the national HPV vaccination programme, and three years after the previous survey. Overall, the school nurses had more favourable attitudes towards the HPV vaccination programme compared to the study in 2013 (p = 0...
2017: PloS One
https://www.readbyqxmd.com/read/28418479/associations-of-maternal-antidepressant-use-during-the-first-trimester-of-pregnancy-with-preterm-birth-small-for-gestational-age-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-in-offspring
#14
Ayesha C Sujan, Martin E Rickert, A Sara Öberg, Patrick D Quinn, Sonia Hernández-Díaz, Catarina Almqvist, Paul Lichtenstein, Henrik Larsson, Brian M D'Onofrio
Importance: Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding. Objective: To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth and neurodevelopmental problems. Design, Setting, and Participants: This retrospective cohort study included Swedish offspring born between 1996 and 2012 and followed up through 2013 or censored by death or emigration...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28416656/effect-of-cholesterol-on-the-molecular-structure-and-transitions-in-a-clinical-grade-lung-surfactant-extract
#15
Jenny Marie Andersson, Carl Grey, Marcus Larsson, Tiago Mendes Ferreira, Emma Sparr
The lipid-protein film covering the interface of the lung alveolar in mammals is vital for proper lung function and its deficiency is related to a range of diseases. Here we present a molecular-level characterization of a clinical-grade porcine lung surfactant extract using a multitechnique approach consisting of [Formula: see text]-[Formula: see text] solid-state nuclear magnetic spectroscopy, small- and wide-angle X-ray scattering, and mass spectrometry. The detailed characterization presented for reconstituted membranes of a lung extract demonstrates that the molecular structure of lung surfactant strongly depends on the concentration of cholesterol...
April 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28415818/mechanistic-characterization-of-a-copper-containing-thiosemicarbazone-with-potent-antitumor-activity
#16
Henning Karlsson, Mårten Fryknäs, Sara Strese, Joachim Gullbo, Gunnar Westman, Ulf Bremberg, Tobias Sjöblom, Tatjana Pandzic, Rolf Larsson, Peter Nygren
BACKGROUND: The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We synthesized a copper complex of VLX50, denoted VLX60, and characterized its antitumor and mechanistic properties. MATERIALS AND METHODS: The cytotoxic effects and mechanistic properties of VLX60 were investigated in monolayer cultures of multiple human cell lines, in tumor cells from patients, in a 3-D spheroid cell culture system and in vivo and were compared with those of VLX50...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414714/excess-atherosclerosis-in-systemic-lupus-erythematosus-a-matter-of-renal-involvement-case-control-study-of-281-sle-patients-and-281-individually-matched-population-controls
#17
Johanna T Gustafsson, Marie Herlitz Lindberg, Iva Gunnarsson, Susanne Pettersson, Kerstin Elvin, John Öhrvik, Anders Larsson, Kerstin Jensen-Urstad, Elisabet Svenungsson
BACKGROUND: Systemic lupus erythematosus (SLE), is a heterogeneous disease which predominantly affects young females (90%). SLE is associated with a shorter life expectancy than in the general population. Standardized mortality ratios (SMR) of 2.4 have been reported, which is comparable to diabetes. In modern societies cardiovascular disease (CVD) is the major cause of premature mortality. Accelerated atherosclerosis is generally assumed to be the underlying cause for SLE related CVD...
2017: PloS One
https://www.readbyqxmd.com/read/28413639/calprotectin-in-serum-and-zonulin-in-serum-and-feces-are-elevated-after-introduction-of-a-diet-with-lower-carbohydrate-content-and-higher-fiber-fat-and-protein-contents
#18
Bodil Ohlsson, Bodil Roth, Ewa Larsson, Peter Höglund
Calprotectin is a marker of inflammation and zonulin is a marker of intestinal permeability. Diets with lower carbohydrate content and higher contents of fat, fiber and protein, e.g., Okinawan-based diet, are considered to reduce inflammation and intestinal permeability. The aim of the present study was to evaluate calprotectin and zonulin levels in serum and feces after intervention with an Okinawan-based Nordic diet. Thirty patients (17 women) with type 2 diabetes, mean age 57.5±8.2 years, BMI 29.9±4.1 kg/m(2), were served the diet during 12 weeks, and were followed for another 16 weeks...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28412224/mechanism-based-selection-of-stabilization-strategy-for-amorphous-formulations-insights-into-crystallization-pathways
#19
Khadijah Edueng, Denny Mahlin, Per Larsson, Christel A S Bergström
We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid or solution-mediated) by which crystallization of amorphous drugs occurs upon dissolution. This protocol then guided how to stabilize the amorphous formulation. Indapamide, metolazone, glibenclamide and glipizide were selected as model drugs and HPMC (Pharmacoat 606) and PVP (K30) as stabilizing polymers...
April 12, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28410621/expanding-the-genotype-of-sj%C3%A3-gren-larsson-syndrome-a-new-case-due-to-two-novel-mutations
#20
E García-Peris, I Latour-Álvarez, M Pestana-Eliche, R Sánchez
No abstract text is available yet for this article.
April 11, 2017: Actas Dermo-sifiliográficas
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