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https://www.readbyqxmd.com/read/29786461/gender-and-diagnostic-impact-on-everyday-technology-use-a-differential-item-functioning-dif-analysis-of-the-everyday-technology-use-questionnaire-etuq
#1
Anders Kottorp, Camilla Malinowsky, Maria Larsson-Lund, Louise Nygård
BACKGROUND: As the use of everyday technology is increasingly important for participation in daily activities, more in-depth knowledge of everyday technology use in relation to diagnosis and gender is needed. The purpose of this study was to investigate the stability of the perceived challenge of a variety of everyday technologies across different samples of varying diagnoses including both males and females. METHODS: This cross-sectional study used 643 data records from clinical and research samples, including persons with dementia or related disorders, acquired brain injury, intellectual disability, various mental or medical disorders, and adults without known diagnoses...
May 22, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29784412/on-the-use-of-spectra-from-portable-raman-and-atr-ir-instruments-in-synthesis-route-attribution-of-a-chemical-warfare-agent-by-multivariate-modeling
#2
Daniel Wiktelius, Linnea Ahlinder, Andreas Larsson, Karin Höjer Holmgren, Rikard Norlin, Per Ola Andersson
Collecting data under field conditions for forensic investigations of chemical warfare agents calls for the use of portable instruments. In this study, a set of aged, crude preparations of sulfur mustard were characterized spectroscopically without any sample preparation using handheld Raman and portable IR instruments. The spectral data was used to construct Random Forest multivariate models for the attribution of test set samples to the synthetic method used for their production. Colored and fluorescent samples were included in the study, which made Raman spectroscopy challenging although fluorescence was diminished by using an excitation wavelength of 1064 nm...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784411/synthesis-route-attribution-of-sulfur-mustard-by-multivariate-data-analysis-of-chemical-signatures
#3
Karin Höjer Holmgren, Saphon Hok, Roger Magnusson, Andreas Larsson, Crister Åstot, Carolyn Koester, Daniel Mew, Alexander K Vu, Armando Alcaraz, Audrey M Williams, Rikard Norlin, Daniel Wiktelius
A multivariate model was developed to attribute samples to a synthetic method used in the production of sulfur mustard (HD). Eleven synthetic methods were used to produce 66 samples for model construction. Three chemists working in both participating laboratories took part in the production, with the aim to introduce variability while reducing the influence of laboratory or chemist specific impurities in multivariate analysis. A gas chromatographic/mass spectrometric data set of peak areas for 103 compounds was subjected to orthogonal partial least squares - discriminant analysis to extract chemical attribution signature profiles and to construct multivariate models for classification of samples...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29776721/process-water-properties-from-hydrothermal-carbonization-of-chemical-sludge-from-a-pulp-and-board-mill
#4
Mikko Mäkelä, Julia Forsberg, Christer Söderberg, Sylvia H Larsson, Olli Dahl
Hydrothermal carbonization (HTC) can be used to break down sludge structure and generate carbonaceous hydrochar suitable for solid fuel or value-added material applications. The separation of char and the reaction medium however generates a filtrate, which needs to treated before potential discharge. Thus, this work determined filtrate properties based on HTC temperature and sludge moisture content and estimated the discharge emissions and the potential increase in analyte loads to an industrial wastewater treatment plant based on derived regression models...
May 15, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29772961/contrasts-in-older-persons-experiences-and-significant-others-perceptions-of-existential-loneliness
#5
Helena Larsson, Anna-Karin Edberg, Ingrid Bolmsjö, Margareta Rämgård
BACKGROUND: As frail older people might have difficulties in expressing themselves, their needs are often interpreted by others, for example, by significant others, whose information health care staff often have to rely on. This, in turn, can put health care staff in ethically difficult situations, where they have to choose between alternative courses of action. One aspect that might be especially difficult to express is that of existential loneliness. We have only sparse knowledge about whether, and in what way, the views of frail older persons and their significant others concerning existential loneliness are in concordance...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29769070/serum-magnesium-levels-and-risk-of-coronary-artery-disease-mendelian-randomisation-study
#6
Susanna C Larsson, Stephen Burgess, Karl Michaëlsson
BACKGROUND: Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary artery disease (CAD). METHODS: This Mendelian randomisation analysis is based on summary-level data from the CARDIoGRAMplusC4D consortium's 1000 Genomes-based genome-wide association meta-analysis of 48 studies with a total of 60,801 CAD cases and 123,504 non-cases...
May 17, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29764511/high-serum-levels-of-pregenomic-rna-reflect-frequently-failing-reverse-transcription-in-hepatitis-b-virus-particles
#7
Kasthuri Prakash, Gustaf E Rydell, Simon B Larsson, Maria Andersson, Gunnar Norkrans, Heléne Norder, Magnus Lindh
BACKGROUND: Hepatocytes infected by hepatitis B virus (HBV) produce different HBV RNA species, including pregenomic RNA (pgRNA), which is reverse transcribed during replication. Particles containing HBV RNA are present in serum of infected individuals, and quantification of this HBV RNA could be clinically useful. METHODS: In a retrospective study of 95 patients with chronic HBV infection, we characterised HBV RNA in serum in terms of concentration, particle association and sequence...
May 15, 2018: Virology Journal
https://www.readbyqxmd.com/read/29763790/the-language-of-smell-connecting-linguistic-and-psychophysical-properties-of-odor-descriptors
#8
Georgios Iatropoulos, Pawel Herman, Anders Lansner, Jussi Karlgren, Maria Larsson, Jonas K Olofsson
The olfactory sense is a particularly challenging domain for cognitive science investigations of perception, memory, and language. Although many studies show that odors often are difficult to describe verbally, little is known about the associations between olfactory percepts and the words that describe them. Quantitative models of how odor experiences are described in natural language are therefore needed to understand how odors are perceived and communicated. In this study, we develop a computational method to characterize the olfaction-related semantic content of words in a large text corpus of internet sites in English...
May 12, 2018: Cognition
https://www.readbyqxmd.com/read/29762755/obstructive-sleep-apnea-during-rem-sleep-is-associated-with-early-signs-of-atherosclerosis-in-women
#9
Mirjam Ljunggren, Eva Lindberg, Karl A Franklin, Patrik Öhagen, Marita Larsson, Jenny Theorell-Haglöw, Tord Naessén
Study Objectives: While obstructive sleep apnea (OSA) is associated with overall cardiovascular disease and mortality, the association with atherosclerotic cardiovascular disease is less clear, especially in women. Recently, it has been suggested that OSA during REM sleep, associated with long apneas and deep desaturations, could have severe cardio-metabolic consequences. The aim of this study was to investigate whether OSA during REM sleep is associated with early signs of atherosclerosis in a population-based sample of women...
May 14, 2018: Sleep
https://www.readbyqxmd.com/read/29760706/complement-opsonized-hiv-1-alters-cross-talk-between-dendritic-cells-and-natural-killer-nk-cells-to-inhibit-nk-killing-and-to-upregulate-pd-1-cxcr3-and-ccr4-on-t-cells
#10
Rada Ellegård, Mohammad Khalid, Cecilia Svanberg, Hanna Holgersson, Ylva Thorén, Mirja Karolina Wittgren, Jorma Hinkula, Sofia Nyström, Esaki M Shankar, Marie Larsson
Dendritic cells (DCs), natural killer (NK) cells, and T cells play critical roles during primary HIV-1 exposure at the mucosa, where the viral particles become coated with complement fragments and mucosa-associated antibodies. The microenvironment together with subsequent interactions between these cells and HIV at the mucosal site of infection will determine the quality of immune response that ensues adaptive activation. Here, we investigated how complement and immunoglobulin opsonization influences the responses triggered in DCs and NK cells, how this affects their cross talk, and what T cell phenotypes are induced to expand following the interaction...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29754000/changes-in-markers-of-liver-function-in-relation-to-changes-in-perfluoroalkyl-substances-a-longitudinal-study
#11
Samira Salihovic, Jordan Stubleski, Anna Kärrman, Anders Larsson, Tove Fall, Lars Lind, P Monica Lind
BACKGROUND: While it is known that perfluoroalkyl substances (PFASs) induce liver toxicity in experimental studies, the evidence of an association in humans is inconsistent. OBJECTIVE: The main aim of the present study was to examine the association of PFAS concentrations and markers of liver function using panel data. METHODS: We investigated 1002 individuals from Sweden (50% women) at ages 70, 75 and 80 in 2001-2014. Eight PFASs were measured in plasma using isotope dilution ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS)...
May 10, 2018: Environment International
https://www.readbyqxmd.com/read/29752553/influence-of-early-life-parental-severe-life-events-on-the-risk-of-type-1-diabetes-in-children-the-dipis-study
#12
Markus Lundgren, Katarina Ellström, Helena Elding Larsson
AIMS: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. METHODS: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis...
May 12, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29747082/critical-knowledge-gaps-and-research-needs-related-to-the-environmental-dimensions-of-antibiotic-resistance
#13
D G Joakim Larsson, Antoine Andremont, Johan Bengtsson-Palme, Kristian Koefoed Brandt, Ana Maria de Roda Husman, Patriq Fagerstedt, Jerker Fick, Carl-Fredrik Flach, William H Gaze, Makoto Kuroda, Kristian Kvint, Ramanan Laxminarayan, Celia M Manaia, Kaare Magne Nielsen, Laura Plant, Marie-Cécile Ploy, Carlos Segovia, Pascal Simonet, Kornelia Smalla, Jason Snape, Edward Topp, Arjon J van Hengel, David W Verner-Jeffreys, Marko P J Virta, Elizabeth M Wellington, Ann-Sofie Wernersson
There is growing understanding that the environment plays an important role both in the transmission of antibiotic resistant pathogens and in their evolution. Accordingly, researchers and stakeholders world-wide seek to further explore the mechanisms and drivers involved, quantify risks and identify suitable interventions. There is a clear value in establishing research needs and coordinating efforts within and across nations in order to best tackle this global challenge. At an international workshop in late September 2017, scientists from 14 countries with expertise on the environmental dimensions of antibiotic resistance gathered to define critical knowledge gaps...
May 7, 2018: Environment International
https://www.readbyqxmd.com/read/29745278/treatment-target-re-classification-of-subjects-comparing-estimation-of-low-density-lipoprotein-cholesterol-by-the-friedewald-equation-and-direct-measurement-of-ldl-cholesterol
#14
Anders Larsson, Emil Hagström, Lennart Nilsson, Maria K Svensson
AIMS: To compare low-density lipoprotein cholesterol (LDL-C) values calculated by the Friedewald equation with direct LDL-C in patient samples and assess the possible impact on re-classification of LDL-C target values for primary prevention or high cardiovascular disease (CVD) risk (<2.5 mmol/L) and secondary prevention or very high CVD risk (<1.8 mmol/L). LDL-C is an important CVD risk factor. Over the last decade, there has been a change in laboratory methodology from indirectly calculated LDL-C with the Friedewald equation to direct LDL-C measurements (dLDL-C)...
May 10, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29744740/co-expression-of-%C3%AE-subunits-with-the-voltage-gated-sodium-channel-na-v-1-7-the-importance-of-subunit-association-and-phosphorylation-and-their-effects-on-channel-pharmacology-and-biophysics
#15
Maxim V Sokolov, Petra Henrich-Noack, Carina Raynoschek, Bo Franzén, Olof Larsson, Martin Main, Michael Dabrowski
The voltage-gated sodium ion channel NaV 1.7 is crucial in pain signaling. We examined how auxiliary β2 and β3 subunits and the phosphorylation state of the channel influence its biophysical properties and pharmacology. The human NaV 1.7α subunit was co-expressed with either β2 or β3 subunits in HEK-293 cells. The β2 subunits and the NaV 1.7α, however, were barely associated as evidenced by immunoprecipitation. Therefore, the β2 subunits did not change the biophysical properties of the channel. In contrast, β3 subunit was clearly associated with NaV 1...
May 10, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29742324/effective-assignment-of-%C3%AE-2-3-%C3%AE-2-6-sialic-acid-isomers-in-lc-ms-ms-based-glycoproteomics
#16
Christian Pett, Waqas Nasir, Carina Sihlbom, Britt-Marie Olsson, Vanessa Caixeta, Manuel Schorlemer, Rene P Zahedi, Göran Larsson, Jonas Nilsson, Ulrika Westerlind
Distinct structural changes of the α2,3/α2,6 sialic acid glycosidic linkages on glycoproteins are of importance in cancer biology, inflammatory diseases and virus tropism. Current glycoproteomic methodologies are, however, not amenable toward high-throughput characterization of sialic acid isomers. To enable such assignments, we developed a mass spectrometry method utilizing synthetic model glycopeptides for the analysis of oxonium ion intensity ratios. This method was successfully applied in large-scale glycoproteomics, allowing site-specific structural characterization of sialic acid isomers...
May 9, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29742247/typical-clinical-and-neuroimaging-features-in-sj%C3%A3-gren-larsson-syndrome
#17
Anderson Rodrigues Brandão de Paiva, Uirá Souto Melo, Fernando Freua, Denise Dória, Katiane Sayão Souza Cabral, Lúcia Inês Macedo-Souza, Leandro Tavares Lucato, Fernando Kok
No abstract text is available yet for this article.
April 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29741364/multiscale-control-of-nanocellulose-assembly-transferring-remarkable-nanoscale-fibril-mechanics-to-macroscale-fibers
#18
Nitesh Mittal, Farhan Ansari, Krishne Gowda V, Christophe Brouzet, Pan Chen, Per Tomas Larsson, Stephan V Roth, Fredrik Lundell, Lars Wågberg, Nicholas A Kotov, L Daniel Söderberg
Nanoscale building blocks of many materials exhibit extraordinary mechanical properties due to their defect-free molecular structure. Translation of these high mechanical properties to macroscopic materials represents a difficult materials engineering challenge due to the necessity to organize these building blocks into multiscale patterns and mitigate defects emerging at larger scales. Cellulose nanofibrils (CNFs), the most abundant structural element in living systems, has impressively high strength and stiffness, but natural or artificial cellulose composites are 3-15 times weaker than the CNFs...
May 9, 2018: ACS Nano
https://www.readbyqxmd.com/read/29730704/normal-bone-microstructure-and-density-but-worse-physical-function-in-older-women-treated-with-selective-serotonin-reuptake-inhibitors-a-cross-sectional-population-based-study
#19
Berit Larsson, Dan Mellström, Lisa Johansson, Anna G Nilsson, Mattias Lorentzon, Daniel Sundh
Depression in the elderly is today often treated with selective serotonin reuptake inhibitors (SSRIs) because of their favorable adverse effect profile. However, treatment with SSRIs is associated with increased risk of fractures. Whether this increased risk depends on reduced bone strength or increased fall risk due to reduced physical function is not certain. The aim was therefore to investigate if treatment with SSRIs is associated with impaired bone microstructure, bone density, or physical function in older women...
May 5, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29730147/development-of-an-international-odor-identification-test-for-children-the-universal-sniff-test
#20
Valentin A Schriever, Eduardo Agosin, Aytug Altundag, Hadas Avni, Helene Cao Van, Carlos Cornejo, Gonzalo de Los Santos, Gad Fishman, Claudio Fragola, Marco Guarneros, Neelima Gupta, Robyn Hudson, Reda Kamel, Antti Knaapila, Iordanis Konstantinidis, Basile N Landis, Maria Larsson, Johan N Lundström, Alberto Macchi, Franklin Mariño-Sánchez, Lenka Martinec Nováková, Eri Mori, Joaquim Mullol, Marie Nord, Valentina Parma, Carl Philpott, Evan J Propst, Ahmed Rawan, Mari Sandell, Agnieszka Sorokowska, Piotr Sorokowski, Lisa-Marie Sparing-Paschke, Carolin Stetzler, Claudia Valder, Jan Vodicka, Thomas Hummel
OBJECTIVE: To assess olfactory function in children and to create and validate an odor identification test to diagnose olfactory dysfunction in children, which we called the Universal Sniff (U-Sniff) test. STUDY DESIGN: This is a multicenter study involving 19 countries. The U-Sniff test was developed in 3 phases including 1760 children age 5-7 years. Phase 1: identification of potentially recognizable odors; phase 2: selection of odorants for the odor identification test; and phase 3: evaluation of the test and acquisition of normative data...
May 2, 2018: Journal of Pediatrics
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