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https://www.readbyqxmd.com/read/28727225/intact-blood-brain-barrier-during-spontaneous-attacks-of-migraine-without-aura-a-3t-dce-mri-study
#1
F M Amin, A Hougaard, S P Cramer, C E Christensen, F Wolfram, H B W Larsson, M Ashina
BACKGROUND AND PURPOSE: The integrity of the blood-brain barrier (BBB) has been questioned in migraine, but BBB permeability has never been investigated during spontaneous migraine attacks. In the present study, BBB permeability during spontaneous attacks of migraine without aura was investigated compared to an interictal state. METHODS: Seventy-four patients suffering from migraine without aura were recruited to participate in this cross-sectional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) study...
July 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28724744/ten-years-transmission-of-the-new-variant-of-chlamydia-trachomatis-in-sweden-prevalence-of-infections-and-associated-complications
#2
Jenny Dahlberg, Ronza Hadad, Karin Elfving, Inger Larsson, Jenny Isaksson, Anders Magnuson, Hans Fredlund, Magnus Unemo, Bjőrn Herrmann
OBJECTIVES: In 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications...
July 19, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28722444/topographically-flat-nanoplasmonic-sensor-chips-for-biosensing-and-materials-science
#3
Ferry Anggoro Ardy Nugroho, Rickard Frost, Tomasz J Antosiewicz, Joachim Fritzsche, Elin M Larsson Langhammer, Christoph Langhammer
Nanoplasmonic sensors typically comprise arrangements of noble metal nanoparticles on a dielectric support. Thus, they are intrinsically characterized by surface topography with corrugations at the 10-100 nm length scale. While irrelevant in some bio- and chemosensing applications, it is also to be expected that the surface topography significantly influences the interaction between solids, fluids, nanoparticles and (bio)molecules, and the nanoplasmonic sensor surface. To address this issue, we present a wafer-scale nanolithography-based fabrication approach for high-temperature compatible, chemically inert, topographically flat, and laterally homogeneous nanoplasmonic sensor chips...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720591/using-fluorescence-to-understand-%C3%AE-subunit-nav-channel-interactions
#4
Rene Barro-Soria, Sara I Liin, H Peter Larsson
No abstract text is available yet for this article.
July 18, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28718940/changes-in-treatment-and-outcome-of-oesophageal-cancer-in-denmark-between-2004-and-2013
#5
D W Kjaer, H Larsson, L B Svendsen, L S Jensen
BACKGROUND: Since 2003, care for patients with oesophageal cancer has been centralized in a few dedicated centres in Denmark. The aim of this study was to assess changes in the treatment and outcome of patients registered in a nationwide database. METHODS: All patients diagnosed with oesophageal cancer or cancer of the gastro-oesophageal junction who underwent oesophagectomy in Denmark between 2004 and 2013, and who were registered in the Danish clinical database of carcinomas in the oesophagus, gastro-oesophageal junction and stomach (DECV database) were included...
July 18, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28716790/human-papillomavirus-prevalence-and-genotype-distribution-among-young-women-and-men-in-maputo-city-mozambique
#6
Viegas Edna Omar, Augusto Orvalho, Ismael Nália, Kaliff Malin, Lillsunde-Larsson Gabriella, Ramqvist Torbjörn, Nilsson Charlotta, Falk Kerstin, Osman Nafissa, Jani Ilesh Vindorai, Andersson Sören
OBJECTIVES: Human papillomavirus (HPV) is a well-known cause of cervical cancer, the second most frequent cancer in female African populations. This study aimed at determining the prevalence of HPV infections and the genotype distribution in young adults aged 18-24, in Maputo city, Mozambique, and to assess the suitability of commercially available HPV vaccines. METHODS: This cross-sectional study was conducted between 2009 and 2011 at a youth clinic in Maputo Central Hospital...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28716088/loss-of-dip2c-in-rko-cells-stimulates-changes-in-dna-methylation-and-epithelial-mesenchymal-transition
#7
Chatarina Larsson, Muhammad Akhtar Ali, Tatjana Pandzic, Anders M Lindroth, Liqun He, Tobias Sjöblom
BACKGROUND: The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in a subset of breast and lung cancers. To understand the role of DIP2C in tumour development we studied the gene in human cancer cells. METHODS: We engineered human DIP2C knockout cells by genome editing in cancer cells. The growth properties of the engineered cells were characterised and transcriptome and methylation analyses were carried out to identify pathways deregulated by inactivation of DIP2C...
July 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28715988/a-metasynthesis-of-phenomenographic-articles-on-understandings-of-work-among-healthcare-professionals
#8
Marta Röing, Inger K Holmström, Jan Larsson
Phenomenography is a qualitative research method based on the assumption that almost any phenomenon will be understood by a group of people in a limited number of ways. Our aim in this article was to identify the different ways work can be understood by healthcare professionals. In a world where the delivery of healthcare is continually changing, a metasynthesis of phenomenographic articles on healthcare professionals' understandings can provide knowledge about the focus and meaning of work for these individuals today...
July 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28715440/transcriptional-profiling-of-the-rat-nucleus-accumbens-after-modest-or-high-alcohol-exposure
#9
Julia Morud, Arghavan Ashouri, Erik Larsson, Mia Ericson, Bo Söderpalm
Alcohol use disorder is a chronic relapsing brain disorder and a global health issue. Prolonged high alcohol consumption increases the risk for dependence development, a complex state that includes progressive alterations in brain function. The molecular mechanisms behind these changes remain to be fully disclosed, but several genes show altered expression in various regions of the rat brain even after modest alcohol exposure. The present study utilizes whole-transcriptome sequencing (RNA-seq) to investigate expression changes in the brain nucleus accumbens (NAc), an area of particular interest in addictive disorders, of alcohol consuming rats...
2017: PloS One
https://www.readbyqxmd.com/read/28706444/patients-conceptions-of-their-own-influence-on-good-treatment-response-to-biological-therapy-in-chronic-inflammatory-arthritis
#10
Ingrid Larsson
BACKGROUND: Biological therapies are common in the treatment of patients with chronic inflammatory arthritis (CIA). However, despite the fact that many patients respond well to their biological therapies, there are still a number of nonresponders. In order to design the best care for patients, it is important to understand how they conceive their own role in their treatment response. OBJECTIVE: To explore how patients with CIA conceive their own influence on a good treatment response to biological therapy...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28705819/mri-of-the-swallow-tail-sign-a-useful-marker-in-the-diagnosis-of-lewy-body-dementia
#11
S Shams, D Fällmar, S Schwarz, L-O Wahlund, D van Westen, O Hansson, E-M Larsson, S Haller
BACKGROUND AND PURPOSE: There are, to date, no MR imaging diagnostic markers for Lewy body dementia. Nigrosome 1, containing dopaminergic cells, in the substantia nigra pars compacta is hyperintense on SWI and has been called the swallow tail sign, disappearing with Parkinson disease. We aimed to study the swallow tail sign and its clinical applicability in Lewy body dementia and hypothesized that the sign would be likewise applicable in Lewy body dementia. MATERIALS AND METHODS: This was a retrospective cross-sectional multicenter study including 97 patients (mean age, 65 ± 10 years; 46% women), consisting of the following: controls (n = 21) and those with Lewy body dementia (n = 19), Alzheimer disease (n = 20), frontotemporal lobe dementia (n = 20), and mild cognitive impairment (n = 17)...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28701495/neurodegenerative-and-psychiatric-diseases-among-families-with-amyotrophic-lateral-sclerosis
#12
Elisa Longinetti, Daniela Mariosa, Henrik Larsson, Weimin Ye, Caroline Ingre, Catarina Almqvist, Paul Lichtenstein, Fredrik Piehl, Fang Fang
OBJECTIVE: To estimate risks of neurodegenerative and psychiatric diseases among patients with amyotrophic lateral sclerosis (ALS) and their families. METHODS: We conducted a register-based nested case-control study during 1990-2013 in Sweden to assess whether patients with ALS had higher risks of other neurodegenerative and psychiatric diseases before diagnosis. We included 3,648 patients with ALS and 36,480 age-, sex-, and county of birth-matched population controls...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28700120/a-15-6-frames-per-second-1-megapixel-multiple-exposure-laser-speckle-contrast-imaging-setup
#13
Martin Hultman, Ingemar Fredriksson, Marcus Larsson, Atila Alvandpour, Tomas Strömberg
A multiple exposure laser speckle contrast imaging (MELSCI) setup for visualizing blood perfusion was developed using a field programmable gate array (FPGA), connected to a 1000 frames per second 1-megapixel camera sensor. Multiple exposure-time images at 1, 2, 4, 8, 16, 32 and 64 ms were calculated by cumulative summation of 64 consecutive snapshot images. The local contrast was calculated for all exposure times using regions of 4x4 pixels. Averaging of multiple contrast images from the 64 ms acquisition was done to improve the signal-to-noise ratio...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28699890/changes-of-mitochondrial-ultrastructure-and-function-during-ageing-in-mice-and-drosophila
#14
Tobias Brandt, Arnaud Mourier, Luke S Tain, Linda Partridge, Nils-Göran Larsson, Werner Kühlbrandt
Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry and discovered distinct age-related changes in both model organisms. Mitochondrial function and ultrastructure are maintained in mouse heart, whereas subpopulations of mitochondria from mouse liver show age-related changes in membrane morphology. Subpopulations of mitochondria from young and old mouse kidney resemble those described for apoptosis...
July 12, 2017: ELife
https://www.readbyqxmd.com/read/28699383/flawed-communications-health-professionals-experience-of-collaboration-in-the-care-of-frail-elderly-patients
#15
Anders Hansson, Ann Svensson, Britt Hedman Ahlström, Lena G Larsson, Berit Forsman, Pia Alsén
AIMS: Frail elderly patients who have multiple illnesses do not fare well in modern health care systems, mainly due to a lack of care planning and flawed communication between health professionals in different care organisations. This is especially noticeable when patients are discharged from hospital. The aim of this study was to explore health care professionals' experience of obstacles and opportunities for collaboration. METHODS: Health professionals were invited to participate in three focus groups, each consisting of a hospital physician, a primary care physician, a hospital nurse, a primary care nurse, a municipal home care nurse or an assistant officer, a physical or occupational therapist and a patient or a family member representative...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28694296/apolipoprotein-c-iii-inhibits-triglyceride-hydrolysis-by-gpihbp1-bound-lpl
#16
Mikael Larsson, Christopher M Allan, Rachel S Jung, Patrick J Heizer, Anne P Beigneux, Stephen G Young, Loren G Fong
Apolipoprotein C-III (apoC-III) is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting lipoprotein lipase (LPL), but that view is based largely on studies of free LPL. We now recognize that intravascular LPL is neither free nor loosely bound but instead is tightly bound to GPIHBP1 on endothelial cells. Here, we revisited the effects of apoC-III on LPL, focusing on apoC-III's capacity to affect the activity of GPIHBP1-bound LPL. We found that TRLs from APOC3 transgenic mice bound normally to GPIHBP1-bound LPL on cultured cells in vitro and to heart capillaries in vivo...
July 10, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28693932/muscle-tissue-saturation-compared-with-muscle-tissue-perfusion-during-low-blood-flows-an-experimental-study
#17
Sisse Anette Thomassen, Benedict Kjærgaard, Aage Kristian Olsen Alstrup, Ole Lajord Munk, Jørgen Frøkiær, Anders Larsson, Bodil Steen Rasmussen
OBJECTIVE: To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model. DESIGN: A prospective, randomized study. SETTING: Research laboratory, single institution. PARTICIPANTS: Eight pigs (69-71 kg)...
March 22, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28693445/older-persons-existential-loneliness-as-interpreted-by-their-significant-others-an-interview-study
#18
Helena Larsson, Margareta Rämgård, Ingrid Bolmsjö
BACKGROUND: In order to better understand people in demanding medical situations, an awareness of existential concerns is important. Studies performed over the last twenty years conclude that when dying and death come closer, as in the case with older people who are stricken by infirmity and diseases, existential concerns will come to the fore. However, studies concerning experiences of existential loneliness (EL) are sparse and, in addition, there is no clear definition of EL. EL is described as a complex phenomenon and referred to as a condition of life, an experience, and a process of inner growth...
July 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28691841/shared-familial-risk-between-bulimic-symptoms-and-alcohol-involvement-during-adolescence
#19
Jessica H Baker, Melissa A Munn-Chernoff, Paul Lichtenstein, Henrik Larsson, Hermine Maes, Kenneth S Kendler
Twin studies show the established relation between bulimic symptoms and problematic alcohol involvement in adult females is partly due to shared familial factors, specifically shared genetic effects. However, it is unclear if similar shared etiological factors exist during adolescence or in males. We examined the familial overlap (i.e., genetic and common environmental correlations) between bulimic symptoms and various levels of alcohol involvement in 16- to 17-year-old female and male same-sex twin pairs using sex-specific biometrical twin modeling...
July 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28686785/liquid-crystal-phantom-for-validation-of-microscopic-diffusion-anisotropy-measurements-on-clinical-mri-systems
#20
Markus Nilsson, Johan Larsson, Dan Lundberg, Filip Szczepankiewicz, Thomas Witzel, Carl-Fredrik Westin, Karin Bryskhe, Daniel Topgaard
PURPOSE: To develop a phantom for validating MRI pulse sequences and data processing methods to quantify microscopic diffusion anisotropy in the human brain. METHODS: Using a liquid crystal consisting of water, detergent, and hydrocarbon, we designed a 0.5-L spherical phantom showing the theoretically highest possible degree of microscopic anisotropy. Data were acquired on the Connectome scanner using echo-planar imaging signal readout and diffusion encoding with axisymmetric b-tensors of varying magnitude, anisotropy, and orientation...
July 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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