keyword
https://read.qxmd.com/read/38527332/impact-of-synthetic-extracellular-matrices-in-combination-therapy-with-amniotic-allografting-in-the-treatment-of-diabetic-foot-wounds-a-case-series
#21
JOURNAL ARTICLE
Arthur Evensen, Jodi Walters, James Dancho, Valarie Samoy, David Jolley
Synthetic extracellular matrices are artificial polymers that are elongated and deposited as a matrix of nanofibers which mimic the native extracellular matrix. RenovoDerm® Anthem™ Wound Matrix (Columbus, Ohio) is comprised of polyglycolic acid and poly (L-lactide-co-caprolactone) which degrade by hydrolysis into a-hydroxy and fatty acids, lowering the pH and promoting regenerative cellular activity including angiogenesis. Amniotic allografts contain growth factors, cytokines, amino acids, extracellular matrix proteins, and hyaluronic acid which are recognized as intrinsic to the wound healing process...
March 22, 2024: Surgical Technology International
https://read.qxmd.com/read/38525737/circulating-mirnas-as-novel-clinical-biomarkers-in-temporal-lobe-epilepsy
#22
REVIEW
Lorenza Guarnieri, Nicola Amodio, Francesca Bosco, Sara Carpi, Martina Tallarico, Luca Gallelli, Vincenzo Rania, Rita Citraro, Antonio Leo, Giovambattista De Sarro
Temporal lobe epilepsy (TLE) represents the most common form of refractory focal epilepsy. The identification of innovative clinical biomarkers capable of categorizing patients with TLE, allowing for improved treatment and outcomes, still represents an unmet need. Circulating microRNAs (c-miRNAs) are short non-coding RNAs detectable in body fluids, which play crucial roles in the regulation of gene expression. Their characteristics, including extracellular stability, detectability through non-invasive methods, and responsiveness to pathological changes and/or therapeutic interventions, make them promising candidate biomarkers in various disease settings...
March 17, 2024: Non-Coding RNA
https://read.qxmd.com/read/38524642/durvalumab-plus-carboplatin-etoposide-treatment-in-a-patient-with-small-cell-lung-cancer-on-hemodialysis-a-case-report-and-literature-review
#23
JOURNAL ARTICLE
Futoshi Ushijima, Tetsunari Hase, Yuki Yamashita, Hangsoo Kim, Tomoya Shimokata, Chiaki Kondo, Tomonori Sato, Tomoya Baba, Shohei Watanabe, Keisuke Futamura, Yuichi Ando, Masashi Mizuno, Makoto Ishii
Little is known about the efficacy and safety of durvalumab plus carboplatin-etoposide treatment in patients with extensive-disease (ED) small-cell lung cancer (SCLC) on hemodialysis. Here, we present a case of a 67-year-old man with pleuroperitoneal communication on continuous ambulatory peritoneal dialysis who was diagnosed with ED-SCLC based on a cytological analysis of the peritoneal fluid. He was switched from peritoneal dialysis to hemodialysis and received durvalumab (1500 mg/body on day 1) plus carboplatin (area under the concentration-time curve = 5, 125 mg on day 1) and etoposide (50 mg/m2 on days 1 and 3) as first-line therapy...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524432/the-production-splitting-method-of-offshore-multilayer-combined-water-flooding-gas-wells-with-gas-dissolving
#24
JOURNAL ARTICLE
Chaoqun Ren, Chuanzhong Deng, Zhehao Jiang, Qiang Fu, Lili Jiang, Yuchuan Guo, Keliu Wu
Offshore gas reservoirs are characterized by thin interlayers, high production, few wells, etc., and are often exploited by multilayer combined mining, whereas the production dynamics of multilayer gas reservoirs are very different from those of single-layer gas reservoirs. Therefore, clarifying the gas production contribution of each layer in multilayer combined gas reservoirs is an important prerequisite for analyzing the potential of gas reservoirs and realizing efficient development. In this paper, unlike the past method of evaluating the gas production contribution of each layer by using the KH attribute of the reservoir, we combined the modified B-L equation considering CO2 dissolution and the multilayer multizone seepage equation to establish a dynamic split model of the production dynamics of multilayer water-driven gas reservoirs, verified the reliability of the model through the numerical model and the results of the production well logging, quantitatively analyzed the degree of influence of each parameter on the contribution of the layered gas production, and designed the orthogonal experiments...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524135/biomarkers-and-computational-models-for-predicting-efficacy-to-tumor-ici-immunotherapy
#25
REVIEW
Yurong Qin, Miaozhe Huo, Xingwu Liu, Shuai Cheng Li
Numerous studies have shown that immune checkpoint inhibitor (ICI) immunotherapy has great potential as a cancer treatment, leading to significant clinical improvements in numerous cases. However, it benefits a minority of patients, underscoring the importance of discovering reliable biomarkers that can be used to screen for potential beneficiaries and ultimately reduce the risk of overtreatment. Our comprehensive review focuses on the latest advancements in predictive biomarkers for ICI therapy, particularly emphasizing those that enhance the efficacy of programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) inhibitors and cytotoxic T-lymphocyte antigen-4 (CTLA-4) inhibitors immunotherapies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523703/effects-of-mgo-nanoparticle-addition-on-the-mechanical-properties-degradation-properties-antibacterial-properties-and-in-vitro-and-in-vivo-biological-properties-of-3d-printed-zn-scaffolds
#26
JOURNAL ARTICLE
Leiting Yu, Fengdong Sun, Yuanyuan Wang, Wei Li, Yufeng Zheng, Guangxin Shen, Yao Wang, Minfang Chen
Bone tissue engineering is the main method for repairing large segment bone defects. In this study, a layer of bioactive MgO nanoparticles was wrapped on the surface of spherical Zn powders, which allowed the MgO nanoparticles to be incorporated into 3D-printed Zn matrix and improved the biodegradation and biocompatibility of the Zn matrix. The results showed that porous pure Zn scaffolds and Zn/MgO scaffolds with skeletal-gyroid (G) model structure were successfully prepared by selective laser melting (SLM)...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38522320/mass-spectrometry-based-proteomic-analysis-of-biological-stains-identifies-body-fluids-specific-markers
#27
JOURNAL ARTICLE
Jian Zhang, Meng Yan, Anquan Ji, Qifan Sun, Wantao Ying
The identification of biological stains and their tissue resource is an important part of forensic research. Current methods suffer from several limitations including poor sensitivity and specificity, trace samples, and sample destruction. In this study, we profiled the proteomes of menstrual blood, peripheral blood, saliva, semen, and vaginal fluid with mass spectrometry technology. Tissue-enhanced and tissue-specific proteins of each group have been proposed as potential biomarkers. These candidate proteins were further annotated and screened through the combination with the Human Protein Atlas database...
March 21, 2024: Forensic Science International
https://read.qxmd.com/read/38520984/advancements-in-optical-fiber-based-wearable-sensors-for-smart-health-monitoring
#28
REVIEW
Rajan Jha, Pratik Mishra, Santosh Kumar
Healthcare system is undergoing a significant transformation from a traditional hospital-centered to an individual-centered one, as a result of escalating chronic diseases, ageing populations, and ever-increasing healthcare costs,. Wearable sensors have become widely used in health monitoring systems since the COVID-19 pandemic. They enable continuous measurement of important health indicators like body temperature, wrist pulse, respiration rate, and non-invasive bio fluids like saliva and perspiration. Over the last few decades, the development has mostly concentrated on electrochemical and electrical wearable sensors...
March 18, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38519009/neuropsychiatric-symptoms-profile-and-markers-of-alzheimer-disease-type-pathology-in-patients-with-lewy-body-dementias
#29
JOURNAL ARTICLE
Chaofan Geng, Leilei Tan, Chenchen
BACKGROUND: To determine whether Lewy body dementia (LBD) patients with likely copathology of Alzheimer's disease (AD) exhibit greater neuropsychiatric symptom (NPS) compared to those without likely AD-type copathology. METHODS: We enrolled 69 individuals diagnosed with Lewy body dementia (LBD), comprising both dementia with Lewy bodies (DLB) (n = 36) and Parkinson's disease dementia (PDD) (n = 33). These participants had accessible cerebrospinal fluid (CSF) markers related to Alzheimer's disease (AD) and cognitive data...
March 20, 2024: Brain Research
https://read.qxmd.com/read/38518838/environmental-toxicants-and-nephrotoxicity-implications-on-mechanisms-and-therapeutic-strategies
#30
REVIEW
Rachna Yadav, Dinesh Kumar, Jiten Singh, Ashok Jangra
Kidneys are one of the most important organs in the human body. In addition to filtering 200 liters of fluid every 24hours, the kidney also regulates acid-base balance, maintains electrolyte balance, and removes waste and toxicants from the body. Nephrotoxicity is the term used to describe the deterioration of kidney function caused by the harmful effects of medications and chemicals found in the environment. Exposure to environmental toxicants is an inevitable side effect of the world's increasing industrialization and it is even more prevalent in underdeveloped nations...
March 20, 2024: Toxicology
https://read.qxmd.com/read/38517089/expanded-spectrum-of-varicella-disease-and-the-need-for-vaccination-in-india
#31
JOURNAL ARTICLE
Padma Srikanth, Ilakkiya Arumugam, Seetha N Jeganathan, Rithvik Ramesh, Lakshmi Narasimhan Ranganathan, Shanthi Vijayaraghavan
Varicella vaccine was first licensed in Japan and South Korea in 1989 for use in healthy children and was introduced in US in 1995. So far, 29 countries have adopted varicella vaccine in their universal immunization program (UIP). No Asian country, India included, has adopted the varicella vaccine as part of their UIP. The extra-cutaneous sites for VZV diseases are central nervous system and gastrointestinal tract, the expanded disease spectrum includes vasculopathy, myelitis, inflammatory bowel disease, perforated ulcers, and gastritis...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38517060/single-hair-analysis-for-gamma-hydroxybutyric-acid-method-optimization-validation-and-application
#32
JOURNAL ARTICLE
Christopher Wiedfeld, Gisela Skopp, Frank Musshoff
As gamma-hydroxybutyric acid (GHB) underlies fast metabolization, its determination from hair may presumably offer a detection window superior to that of body fluids. Due to the wide range of endogenous concentration levels, the evidence of an exogenous ingestion is challenging. As already shown for other drugs, the temporal resolution obtained by applying single hair microanalysis provides further information. Therefore, a method for the extraction and quantification of GHB in 2-mm hair segments (seg) was optimized and validated (limit of detection [LOD]: 2...
March 22, 2024: Drug Testing and Analysis
https://read.qxmd.com/read/38516858/sensitive-detection-of-herbicide-residues-using-field-amplified-sample-injection-coupled-with-electrokinetic-supercharging-in-flow-gated-capillary-electrophoresis
#33
JOURNAL ARTICLE
Ying Gong, Maojun Gong
Residues of glyphosate (GlyP) and its major degradation product, aminomethylphosphonic acid (AMPA), widely exist in the water system and plant products and thus are also present in the bodies of animals and humans. Although no solid evidence has been obtained, the concern about the cancer risk of GlyP is persistent. The measurement of GlyP and AMPA in trace levels is often needed but lacks readily available analytical approaches with detection sensitivity, accuracy and speed. This study aims to develop a simple and robust technique for the sensitive detection of GlyP and AMPA residues in a surface water system with flow-gated capillary electrophoresis (CE)...
March 22, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38516184/transfer-of-membrane-s-matter-s-non-genetic-inheritance-of-metabolic-phenotypes
#34
JOURNAL ARTICLE
Günter A Müller, Timo D Müller
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer phospholipid layer of eukaryotic plasma membranes exclusively by a glycolipid. GPI-APs are not only released into extracellular compartments by lipolytic cleavage. In addition, certain GPI-APs with the glycosylphosphatidylinositol anchor including their fatty acids remaining coupled to the carboxy-terminus of their protein components are also detectable in body fluids, in response to certain stimuli, such as oxidative stress, radicals or high-fat diet...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38513592/mebendazole-preferentially-inhibits-cilia-formation-and-exerts-anticancer-activity-by-synergistically-augmenting-dna-damage
#35
JOURNAL ARTICLE
Juyeon Hong, Keun Yeong Kwon, Dong Gil Jang, Taejoon Kwon, Haejin Yoon, Tae Joo Park
The cilium is a microtubule-based organelle that plays a pivotal role in embryonic development and maintenance of physiological functions in the human body. In addition to their function as sensors that transduce diverse extracellular signals, including growth factors, fluid flow, and physical forces, cilia are intricately involved in cell cycle regulation and preservation of DNA integrity, as their formation and resorption dynamics are tightly linked to cell cycle progression. Recently, several studies have linked defects in specific ciliary proteins to the DNA damage response...
March 20, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38513299/promoting-effect-of-phosvitin-in-the-mineralization-of-eggshell-inner-membrane-with-the-application-in-osteogenic-induction-scaffold
#36
JOURNAL ARTICLE
Wei Liu, Qiancheng Zhao, Cuie Tang, Zhaoxia Cai, Yongguo Jin, Dong Uk Ahn, Xi Huang
Exploring affordable and easily prepared inorganic-organic hybrid membrane materials has attracted a great interest in the bone repair field. This study is based on biomimetic mineralization technique to study the role of phosvitin (PV) in the mineralized process of eggshell inner membrane. Results showed that PV promoted the formation of hydroxyapatite on the eggshell inner membrane surface, and the phosvitin content in the simulated body fluid was decreased during the mineralization process. Besides, in vitro preosteoblast experiments indicated that mineralized membrane with PV exhibited more conducive to cell proliferation and differentiation than that mineralized membrane without PV...
March 11, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38512116/enhancement-in-the-induction-heating-efficacy-of-sol-gel-derived-sio-2-cao-na-2-o-p-2-o-5-bioglass-ceramics-by-incorporating-magnetite-nanoparticles
#37
JOURNAL ARTICLE
Nitu, Rushikesh Fopase, Lalit Mohan Pandey, Krishna Priya Hazarika, Jyoti Prasad Borah, Rajendra K Singh, Ananthakrishnan Srinivasan
Magnetite (Fe3 O4 ) nanoparticle (MNP)-substituted glass-ceramic (MSGC) powders with compositions of (45 - x )SiO2 -24.5CaO-24.5Na2 O-6P2 O5 - x Fe3 O4 ( x = 5, 8, and 10 wt%) have been prepared by a sol-gel route by introducing Fe3 O4 nanoparticles during the synthesis. The X-ray diffraction patterns of the as-prepared MSGC nanopowders revealed the presence of combeite (Na2 Ca2 Si3 O9 ), magnetite, and sodium nitrate (NaNO3 ) crystalline phases. Heat-treatment up to 700 °C for 1 h resulted in the complete dissolution of NaNO3 along with partial conversion of magnetite into hematite (α-Fe2 O3 )...
March 21, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38510690/prosaposin-is-a-novel-coenzyme-q10-binding-protein
#38
JOURNAL ARTICLE
Makoto Hasegawa, Yorihiro Yamamoto, Akio Fujisawa, Misato Kashiba
Coenzyme Q10 (CoQ10) is essential for mitochondrial ATP production and functions as an important antioxidant in every biomembrane and lipoprotein. Due to its hydrophobicity, a binding and transfer protein for CoQ10 is plausible, and we previously described saposin B as a CoQ10-binding and transfer protein. Here, we report that prosaposin, the precursor of saposin B, also binds CoQ10. As prosaposin is both a secretory protein and integral membrane protein, it is ubiquitous in the body. Prosaposin was isolated from human seminal plasma, and CoQ10 was extracted from hexane solution into the water phase...
March 2024: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/38510452/evaluation-of-serum-and-urine-biomarkers-for-severe-covid-19
#39
JOURNAL ARTICLE
Yaroslav D Shansky, Oleg O Yanushevich, Alina V Gospodarik, Igor V Maev, Natella I Krikheli, Oleg V Levchenko, Andrew V Zaborovsky, Vladimir V Evdokimov, Alexander A Solodov, Petr A Bely, Dmitry N Andreev, Anna N Serkina, Sulejman S Esiev, Anastacia V Komarova, Philip S Sokolov, Aleksei K Fomenko, Mikhail K Devkota, Sergei V Tsaregorodtsev, Julia A Bespyatykh
INTRODUCTION: The new coronavirus disease, COVID-19, poses complex challenges exacerbated by several factors, with respiratory tissue lesions being notably significant among them. Consequently, there is a pressing need to identify informative biological markers that can indicate the severity of the disease. Several studies have highlighted the involvement of proteins such as APOA1, XPNPEP2, ORP150, CUBN, HCII, and CREB3L3 in these respiratory tissue lesions. However, there is a lack of information regarding antibodies to these proteins in the human body, which could potentially serve as valuable diagnostic markers for COVID-19...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38509342/microfluidic-based-systems-for-the-management-of-diabetes
#40
REVIEW
Shuyu Zhang, Anne E Staples
Diabetes currently affects approximately 500 million people worldwide and is one of the most common causes of mortality in the United States. To diagnose and monitor diabetes, finger-prick blood glucose testing has long been used as the clinical gold standard. For diabetes treatment, insulin is typically delivered subcutaneously through cannula-based syringes, pens, or pumps in almost all type 1 diabetic (T1D) patients and some type 2 diabetic (T2D) patients. These painful, invasive approaches can cause non-adherence to glucose testing and insulin therapy...
March 20, 2024: Drug Delivery and Translational Research
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